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Literature summary for 1.1.1.21 extracted from

  • Hwang, Y.C.; Shaw, S.; Kaneko, M.; Redd, H.; Marrero, M.B.; Ramasamy, R.
    Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury (2005), FASEB J., 19, 795-797.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transgenic C57BL6 background mice overexpressing human aldose reductase exhibit increased JAK2 and STAT5 activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of AR protects the ischemic myocardium and is associated with improved energy metabolism Homo sapiens
additional information inhibition of AR protects the ischemic myocardium and is associated with improved energy metabolism Rattus norvegicus
zopolrestat
-
Homo sapiens
zopolrestat
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose + NADPH + H+ Homo sapiens the aldose reductase pathway has been demonstrated to be a key component of myocardial ischemia reperfusion injury, inhibition of AR protects the ischemic myocardium and is associated with improved energy metabolism, overview, pharmacological inhibition of the enzyme or sorbitol dehydrogenase blocks JAK2 and STAT5 activation and is associated with lower lactate/pyruvate ratio and lower protein kinase C activity, mechanism, overview sorbitol + NADP+
-
?
D-glucose + NADPH + H+ Rattus norvegicus the aldose reductase pathway has been demonstrated to be a key component of myocardial ischemia reperfusion injury, inhibition of AR protects the ischemic myocardium and is associated with improved energy metabolism, overview, pharmacological inhibition of the enzyme or sorbitol dehydrogenase blocks JAK2 and STAT5 activation and is associated with lower lactate/pyruvate ratio and lower protein kinase C activity, mechanism, overview sorbitol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
myocardium
-
Homo sapiens
-
myocardium
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose + NADPH + H+
-
Homo sapiens sorbitol + NADP+
-
?
D-glucose + NADPH + H+
-
Rattus norvegicus sorbitol + NADP+
-
?
D-glucose + NADPH + H+ the aldose reductase pathway has been demonstrated to be a key component of myocardial ischemia reperfusion injury, inhibition of AR protects the ischemic myocardium and is associated with improved energy metabolism, overview, pharmacological inhibition of the enzyme or sorbitol dehydrogenase blocks JAK2 and STAT5 activation and is associated with lower lactate/pyruvate ratio and lower protein kinase C activity, mechanism, overview Homo sapiens sorbitol + NADP+
-
?
D-glucose + NADPH + H+ the aldose reductase pathway has been demonstrated to be a key component of myocardial ischemia reperfusion injury, inhibition of AR protects the ischemic myocardium and is associated with improved energy metabolism, overview, pharmacological inhibition of the enzyme or sorbitol dehydrogenase blocks JAK2 and STAT5 activation and is associated with lower lactate/pyruvate ratio and lower protein kinase C activity, mechanism, overview Rattus norvegicus sorbitol + NADP+
-
?

Synonyms

Synonyms Comment Organism
aldose reductase
-
Homo sapiens
aldose reductase
-
Rattus norvegicus
ARI
-
Homo sapiens
ARI
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus