Cloned (Comment) | Organism |
---|---|
overexpression of the enzyme in mice | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | genetic polymorphisms associated with the human aldose reductase gene have been found to be associated with diabetic complications | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + NADPH + H+ | Homo sapiens | the aldose reductase polyol pathway pathway and advanced glycation end products, AGEs, are involved in myocardial ischemic injury in diabetis, mechanism, AGE interacts with its receptor, RAGE, resulting in cardiac dysfunction, overview, genetic polymorphisms associated with the human aldose reductase gene have been found to be associated with diabetic complications, mechanisms implicated in polyol pathwaylinked functional abnormalities include myoinositol depletion and associated impaired phosphatidylinositol metabolism, osmotic imbalance due to accumulation of sorbitol, and decreased availability of NADPH | sorbitol + NADP+ | - |
? | |
D-glucose + NADPH + H+ | Mus musculus | the aldose reductase polyol pathway pathway and advanced glycation end products, AGEs, are involved in myocardial ischemic injury in diabetis, mechanisms implicated in polyol pathwaylinked functional abnormalities include myoinositol depletion and associated impaired phosphatidylinositol metabolism, osmotic imbalance due to accumulation of sorbitol, and decreased availability of NADPH | sorbitol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
heart | very low enzyme expression and activity in mice | Mus musculus | - |
myocardium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + NADPH + H+ | - |
Mus musculus | sorbitol + NADP+ | - |
? | |
D-glucose + NADPH + H+ | - |
Homo sapiens | sorbitol + NADP+ | - |
? | |
D-glucose + NADPH + H+ | the aldose reductase polyol pathway pathway and advanced glycation end products, AGEs, are involved in myocardial ischemic injury in diabetis, mechanism, AGE interacts with its receptor, RAGE, resulting in cardiac dysfunction, overview, genetic polymorphisms associated with the human aldose reductase gene have been found to be associated with diabetic complications, mechanisms implicated in polyol pathwaylinked functional abnormalities include myoinositol depletion and associated impaired phosphatidylinositol metabolism, osmotic imbalance due to accumulation of sorbitol, and decreased availability of NADPH | Homo sapiens | sorbitol + NADP+ | - |
? | |
D-glucose + NADPH + H+ | the aldose reductase polyol pathway pathway and advanced glycation end products, AGEs, are involved in myocardial ischemic injury in diabetis, mechanisms implicated in polyol pathwaylinked functional abnormalities include myoinositol depletion and associated impaired phosphatidylinositol metabolism, osmotic imbalance due to accumulation of sorbitol, and decreased availability of NADPH | Mus musculus | sorbitol + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Mus musculus |
monomer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Mus musculus |
aldose reductase | - |
Homo sapiens |
AR | - |
Mus musculus |
AR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent on | Mus musculus | |
NADPH | dependent on | Homo sapiens |