Protein Variants | Comment | Organism |
---|---|---|
L263F | site-directed mutagenesis, about 10% of wild-type activity | Homo sapiens |
additional information | identification of nine genetic variants in type II enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Mycophenolic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0163 | - |
NAD+ | wild-type, 37°C, pH 8.0 | Homo sapiens | |
0.0227 | - |
NAD+ | mutant L263F, 37°C, pH 8.0 | Homo sapiens | |
0.042 | - |
inosine 5'-phosphate | mutant L263F, 37°C, pH 8.0 | Homo sapiens | |
0.0458 | - |
inosine 5'-phosphate | wild-type, 37°C, pH 8.0 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
IMPDH type II | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | - |
Homo sapiens | xanthosine 5'-phosphate + NADH | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.17 | - |
inosine 5'-phosphate | mutant L263F, 37°C, pH 8.0 | Homo sapiens | |
1.47 | - |
inosine 5'-phosphate | wild-type, 37°C, pH 8.0 | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.011 | - |
Mycophenolic acid | wild-type, 37°C, pH 8.0 | Homo sapiens | |
0.0182 | - |
Mycophenolic acid | mutant L263F, 37°C, pH 8.0 | Homo sapiens |