Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-3-furan-2-yl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]prop-2-enamide | isozyme IMPDH II IC50: 28 nM | Homo sapiens | |
(2E)-3-furan-2-yl-N-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]prop-2-enamide | isozyme IMPDH II IC50: 0.002 mM | Homo sapiens | |
1-(3-methylphenyl)-3-[4-(1,3-oxazol-5-yl)phenyl]urea | isozyme IMPDH II IC50: 640 nM | Homo sapiens | |
1-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea | isozyme IMPDH II IC50: 43 nM | Homo sapiens | |
1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea | isozyme IMPDH II IC50: 19 nM | Homo sapiens | |
1-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea | isozyme IMPDH II IC50: 500 nM | Homo sapiens | |
2-(1,3-oxazol-5-yl)-5-[(5-phenyl-1,3-oxazol-2-yl)amino]phenol | isozyme IMPDH II IC50: 0.0016 mM | Homo sapiens | |
2-cyano-1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-3-phenylguanidine | isozyme IMPDH II IC50: 240 nM | Homo sapiens | |
2-hydroxy-N-[2-(2-[[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methylacetamide | isozyme IMPDH II IC50: 41 nM | Homo sapiens | |
3-hydroxy-N-methyl-N-[2-(2-[[3-methyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]propanamide | isozyme IMPDH II IC50: 100 nM | Homo sapiens | |
3-hydroxy-N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methylpropanamide | isozyme IMPDH II IC50: 21 nM | Homo sapiens | |
7-methoxy-6-(1,3-oxazol-4-yl)-2-phenylquinolin-4(1H)-one | isozyme IMPDH II IC50: 210 nM | Homo sapiens | |
7-methoxy-6-(1,3-oxazol-5-yl)-2-phenoxyquinolin-4(1H)-one | isozyme IMPDH II IC50: 8 nM | Homo sapiens | |
additional information | determination and analysis of structure-activity relationships of the different inhibitor molecules, overview | Homo sapiens | |
Mycophenolic acid | key binding interactions for the benzofuranone residue mycophenolic acid and the N-[3-methoxy-4-(5-oxazolyl)phenyl] fragment of VX-497, the benzofuranone ring mycophenolic acid binds in a spatially restricted region of the NAD+ binding site packing with the hypoxanthine ring xanthosine 5'-phosphate, the carbonyl oxygen and hydroxy residues are involved in a hydrogen bond array that involves Gly326, Thr333 and Gln441, the appending methyl substituent of the benzofuranone system, resides in a small hydrophobic pocket defined by the planes of Asn303 amide and Arg322 guanidine, the phenyl oxazole moiety of VX-497 binds in the same region as the benzofuranone ring of mycophenolic acid, forming hydrogen bonds between the oxazole nitrogen and oxygen with Gly326 and possibly Thr333, respectively, the methoxy residue binds in the same pocket as the benzofuranone methyl in mycophenolic acid | Homo sapiens | |
N-methyl-N'-[4-(1,3-oxazol-5-yl)phenyl]-6-phenyl-1,3,5-triazine-2,4-diamine | isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | |
N-methyl-N'-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-6-phenyl-1,3,5-triazine-2,4-diamine | isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | |
N-methyl-N-[2-(2-[[3-methyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-morpholin-4-ylpropanamide | isozyme IMPDH II IC50: 45 nM | Homo sapiens | |
N-tert-butyl-N'-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]ethanediamide | isozyme IMPDH II IC50: 55 nM | Homo sapiens | |
N-tert-butyl-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]ethanediamide | isozyme IMPDH II IC50: 10 nM | Homo sapiens | |
N-tert-butyl-N'-[4-(1,3-oxazol-5-yl)phenyl]ethanediamide | isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | |
N-tert-butyl-N'-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]ethanediamide | isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | |
N-[2-(2-[[3-(chloromethyl)-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide | isozyme IMPDH II IC50: 47 nM | Homo sapiens | |
N-[2-(2-[[3-bromo-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide | isozyme IMPDH II IC50: 28 nM | Homo sapiens | |
N-[2-(2-[[3-bromo-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide | isozyme IMPDH II IC50: 21 nM | Homo sapiens | |
N-[2-(2-[[3-chloro-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide | isozyme IMPDH II IC50: 48 nM | Homo sapiens | |
N-[2-(2-[[3-ethyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide | isozyme IMPDH II IC50: 310 nM | Homo sapiens | |
N-[2-(2-[[3-ethyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide | isozyme IMPDH II IC50: 21 nM | Homo sapiens | |
N-[2-(2-[[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-2-morpholin-4-ylacetamide | isozyme IMPDH II IC50: 91 nM | Homo sapiens | |
N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide | isozyme IMPDH II IC50: 16 nM | Homo sapiens | |
N-[2-chloro-3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | |
N-[2-chloro-5-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 0.0016 mM | Homo sapiens | |
N-[2-fluoro-5-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | |
N-[3-bromo-4-(1,3-oxazol-5-yl)phenyl]-N'-tert-butylethanediamide | isozyme IMPDH II IC50: 50 nM | Homo sapiens | |
N-[3-chloro-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | |
N-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 88 nM | Homo sapiens | |
N-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine | isozyme IMPDH II IC50: 340 nM | Homo sapiens | |
N-[3-ethoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 0.010 mM | Homo sapiens | |
N-[3-methoxy-4-(1,3-oxazol-2-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 190 nM | Homo sapiens | |
N-[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 57 nM | Homo sapiens | |
N-[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine | isozyme IMPDH II IC50: 0.0016 mM | Homo sapiens | |
N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 20 nM | Homo sapiens | |
N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine | isozyme IMPDH II IC50: 76 nM | Homo sapiens | |
N-[3-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 410 nM | Homo sapiens | |
N-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 0.002 mM | Homo sapiens | |
N-[3-methoxy-4-(4-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | |
N-[3-methyl-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | |
N-[4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | |
N-[4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | |
N-[4-(2,4-dimethyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 0.002 mM | Homo sapiens | |
N-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | |
VX-497 | key binding interactions for the benzofuranone residue mycophenolic acid and the N-[3-methoxy-4-(5-oxazolyl)phenyl] fragment of VX-497, the benzofuranone ring mycophenolic acid binds in a spatially restricted region of the NAD+ binding site packing with the hypoxanthine ring xanthosine 5'-phosphate, the carbonyl oxygen and hydroxy residues are involved in a hydrogen bond array that involves Gly326, Thr333 and Gln441, the appending methyl substituent of the benzofuranone system, resides in a small hydrophobic pocket defined by the planes of Asn303 amide and Arg322 guanidine, the phenyl oxazole moiety of VX-497 binds in the same region as the benzofuranone ring of mycophenolic acid, forming hydrogen bonds between the oxazole nitrogen and oxygen with Gly326 and possibly Thr333, respectively, the methoxy residue binds in the same pocket as the benzofuranone methyl in mycophenolic acid | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | Homo sapiens | rate-limiting step of the de novo guanine nucleotide biosynthesis | xanthosine 5'-phosphate + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme IMPDH II | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | - |
Homo sapiens | xanthosine 5'-phosphate + NADH | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | rate-limiting step of the de novo guanine nucleotide biosynthesis | Homo sapiens | xanthosine 5'-phosphate + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IMPDH | - |
Homo sapiens |
inosine monophosphate dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000008 | - |
isozyme IMPDH II IC50: 8 nM | Homo sapiens | 7-methoxy-6-(1,3-oxazol-5-yl)-2-phenoxyquinolin-4(1H)-one | |
0.00001 | - |
isozyme IMPDH II IC50: 10 nM | Homo sapiens | N-tert-butyl-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]ethanediamide | |
0.000016 | - |
isozyme IMPDH II IC50: 16 nM | Homo sapiens | N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide | |
0.000019 | - |
isozyme IMPDH II IC50: 19 nM | Homo sapiens | 1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea | |
0.00002 | - |
isozyme IMPDH II IC50: 20 nM | Homo sapiens | N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.000021 | - |
isozyme IMPDH II IC50: 21 nM | Homo sapiens | 3-hydroxy-N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methylpropanamide | |
0.000021 | - |
isozyme IMPDH II IC50: 21 nM | Homo sapiens | N-[2-(2-[[3-bromo-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide | |
0.000021 | - |
isozyme IMPDH II IC50: 21 nM | Homo sapiens | N-[2-(2-[[3-ethyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide | |
0.000028 | - |
isozyme IMPDH II IC50: 28 nM | Homo sapiens | (2E)-3-furan-2-yl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]prop-2-enamide | |
0.000028 | - |
isozyme IMPDH II IC50: 28 nM | Homo sapiens | N-[2-(2-[[3-bromo-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide | |
0.000041 | - |
isozyme IMPDH II IC50: 41 nM | Homo sapiens | 2-hydroxy-N-[2-(2-[[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methylacetamide | |
0.000043 | - |
isozyme IMPDH II IC50: 43 nM | Homo sapiens | 1-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea | |
0.000045 | - |
isozyme IMPDH II IC50: 45 nM | Homo sapiens | N-methyl-N-[2-(2-[[3-methyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-morpholin-4-ylpropanamide | |
0.000047 | - |
isozyme IMPDH II IC50: 47 nM | Homo sapiens | N-[2-(2-[[3-(chloromethyl)-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide | |
0.000048 | - |
isozyme IMPDH II IC50: 48 nM | Homo sapiens | N-[2-(2-[[3-chloro-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide | |
0.00005 | - |
isozyme IMPDH II IC50: 50 nM | Homo sapiens | N-[3-bromo-4-(1,3-oxazol-5-yl)phenyl]-N'-tert-butylethanediamide | |
0.000055 | - |
isozyme IMPDH II IC50: 55 nM | Homo sapiens | N-tert-butyl-N'-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]ethanediamide | |
0.000057 | - |
isozyme IMPDH II IC50: 57 nM | Homo sapiens | N-[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.000076 | - |
isozyme IMPDH II IC50: 76 nM | Homo sapiens | N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine | |
0.000088 | - |
isozyme IMPDH II IC50: 88 nM | Homo sapiens | N-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.000091 | - |
isozyme IMPDH II IC50: 91 nM | Homo sapiens | N-[2-(2-[[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-2-morpholin-4-ylacetamide | |
0.0001 | - |
isozyme IMPDH II IC50: 100 nM | Homo sapiens | 3-hydroxy-N-methyl-N-[2-(2-[[3-methyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]propanamide | |
0.00019 | - |
isozyme IMPDH II IC50: 190 nM | Homo sapiens | N-[3-methoxy-4-(1,3-oxazol-2-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.00021 | - |
isozyme IMPDH II IC50: 210 nM | Homo sapiens | 7-methoxy-6-(1,3-oxazol-4-yl)-2-phenylquinolin-4(1H)-one | |
0.00024 | - |
isozyme IMPDH II IC50: 240 nM | Homo sapiens | 2-cyano-1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-3-phenylguanidine | |
0.00031 | - |
isozyme IMPDH II IC50: 310 nM | Homo sapiens | N-[2-(2-[[3-ethyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide | |
0.00034 | - |
isozyme IMPDH II IC50: 340 nM | Homo sapiens | N-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine | |
0.00041 | - |
isozyme IMPDH II IC50: 410 nM | Homo sapiens | N-[3-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.0005 | - |
isozyme IMPDH II IC50: 500 nM | Homo sapiens | 1-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea | |
0.00064 | - |
isozyme IMPDH II IC50: 640 nM | Homo sapiens | 1-(3-methylphenyl)-3-[4-(1,3-oxazol-5-yl)phenyl]urea | |
0.0016 | - |
isozyme IMPDH II IC50: 0.0016 mM | Homo sapiens | 2-(1,3-oxazol-5-yl)-5-[(5-phenyl-1,3-oxazol-2-yl)amino]phenol | |
0.0016 | - |
isozyme IMPDH II IC50: 0.0016 mM | Homo sapiens | N-[2-chloro-5-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.0016 | - |
isozyme IMPDH II IC50: 0.0016 mM | Homo sapiens | N-[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine | |
0.002 | - |
isozyme IMPDH II IC50: 0.002 mM | Homo sapiens | (2E)-3-furan-2-yl-N-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]prop-2-enamide | |
0.002 | - |
isozyme IMPDH II IC50: 0.002 mM | Homo sapiens | N-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.002 | - |
isozyme IMPDH II IC50: 0.002 mM | Homo sapiens | N-[4-(2,4-dimethyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.005 | - |
isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | N-[4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.005 | - |
isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | N-[2-fluoro-5-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.005 | - |
isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | N-[2-chloro-3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.005 | - |
isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | N-tert-butyl-N'-[4-(1,3-oxazol-5-yl)phenyl]ethanediamide | |
0.005 | - |
isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | N-methyl-N'-[4-(1,3-oxazol-5-yl)phenyl]-6-phenyl-1,3,5-triazine-2,4-diamine | |
0.005 | - |
isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | N-methyl-N'-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-6-phenyl-1,3,5-triazine-2,4-diamine | |
0.005 | - |
isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | N-tert-butyl-N'-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]ethanediamide | |
0.005 | - |
isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | N-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.005 | - |
isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | N-[3-methoxy-4-(4-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.005 | - |
isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | N-[4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.005 | - |
isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | N-[3-methyl-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.005 | - |
isozyme IMPDH II IC50: 0.005 mM | Homo sapiens | N-[3-chloro-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine | |
0.01 | - |
isozyme IMPDH II IC50: 0.010 mM | Homo sapiens | N-[3-ethoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine |