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Literature summary for 1.1.1.2 extracted from

  • Ohta, M.; Tanimoto, T.; Tanaka, A.
    Localization, isolation and properties of three NADPH-dependent aldehyde reducing enzymes from dog kidney (1991), Biochim. Biophys. Acta, 1078, 395-403.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Alconil
-
Canis lupus familiaris
Alconil
-
Rattus norvegicus
epalrestat
-
Canis lupus familiaris
epalrestat
-
Rattus norvegicus
M79175
-
Canis lupus familiaris
ponalrestat
-
Canis lupus familiaris
ponalrestat
-
Homo sapiens
sodium valproate
-
Bos taurus
sodium valproate
-
Canis lupus familiaris
sodium valproate
-
Homo sapiens
sodium valproate
-
Ovis aries
sorbinil
-
Canis lupus familiaris
sorbinil
-
Homo sapiens
sorbinil
-
Ovis aries
sorbinil
-
Rattus norvegicus
Tolrestat
-
Canis lupus familiaris
Tolrestat
-
Homo sapiens
Tolrestat
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5
-
D-glucuronate outer medulla enzyme Canis lupus familiaris
3.22
-
D-glucuronate inner medulla enzyme Canis lupus familiaris
3.34
-
D-glucuronate cortex enzyme Canis lupus familiaris
4.67
-
DL-glyceraldehyde inner medulla enzyme Canis lupus familiaris
4.67
-
DL-glyceraldehyde enzyme from inner medulla, at pH 6.2 and 25°C Canis lupus familiaris
4.68
-
DL-glyceraldehyde cortex enzyme Canis lupus familiaris
4.68
-
DL-glyceraldehyde enzyme from brain cortex, at pH 6.2 and 25°C Canis lupus familiaris
5.92
-
DL-glyceraldehyde outer medulla enzyme Canis lupus familiaris
5.92
-
DL-glyceraldehyde enzyme from outer medulla, at pH 6.2 and 25°C Canis lupus familiaris
845
-
D-xylose outer medulla enzyme Canis lupus familiaris
1152
-
D-xylose inner medulla enzyme Canis lupus familiaris
1497
-
D-xylose cortex enzyme Canis lupus familiaris

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
gel filtration Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucuronate + NADPH Cavia porcellus
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Mus musculus
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Homo sapiens
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Rattus norvegicus
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Sus scrofa
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Bos taurus
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Oryctolagus cuniculus
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Ovis aries
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Canis lupus familiaris
-
L-gulonate + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Cavia porcellus
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Mus musculus
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Homo sapiens
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Sus scrofa
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Oryctolagus cuniculus
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Ovis aries
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Canis lupus familiaris
-
glycerol + NADP+
-
r
L-glyceraldehyde + NADPH Cavia porcellus
-
glycerol + NADP+
-
r
L-glyceraldehyde + NADPH Mus musculus
-
glycerol + NADP+
-
r
L-glyceraldehyde + NADPH Homo sapiens
-
glycerol + NADP+
-
r
L-glyceraldehyde + NADPH Rattus norvegicus
-
glycerol + NADP+
-
r
L-glyceraldehyde + NADPH Sus scrofa
-
glycerol + NADP+
-
r
L-glyceraldehyde + NADPH Oryctolagus cuniculus
-
glycerol + NADP+
-
r
L-glyceraldehyde + NADPH Ovis aries
-
glycerol + NADP+
-
r
L-glyceraldehyde + NADPH Canis lupus familiaris
-
glycerol + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
bovine
-
Canis lupus familiaris
-
-
-
Cavia porcellus
-
guinea pig
-
Homo sapiens
-
human
-
Mus musculus
-
mouse
-
Oryctolagus cuniculus
-
rabbit
-
Ovis aries
-
sheep
-
Ovis aries
-
Suffolk-Hampshire
-
Rattus norvegicus
-
rat
-
Sus scrofa
-
pig
-

Purification (Commentary)

Purification (Comment) Organism
-
Canis lupus familiaris

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Cavia porcellus
-
kidney
-
Mus musculus
-
kidney
-
Homo sapiens
-
kidney
-
Sus scrofa
-
kidney
-
Bos taurus
-
kidney
-
Oryctolagus cuniculus
-
kidney
-
Ovis aries
-
kidney renal cortex Rattus norvegicus
-
kidney renal cortex, outer medulla and inner medulla Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.35
-
-
Canis lupus familiaris

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucuronate + NADPH
-
Cavia porcellus L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Cavia porcellus L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Mus musculus L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Mus musculus L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Sus scrofa L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Sus scrofa L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Bos taurus L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Bos taurus L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Oryctolagus cuniculus L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Oryctolagus cuniculus L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Ovis aries L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Ovis aries L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Canis lupus familiaris L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Canis lupus familiaris L-gulonate + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Cavia porcellus glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Mus musculus glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Rattus norvegicus glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Sus scrofa glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Oryctolagus cuniculus glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Ovis aries glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Canis lupus familiaris glycerol + NADP+
-
r
D-xylose + NADPH
-
Rattus norvegicus ? + NADP+
-
?
D-xylose + NADPH
-
Sus scrofa ? + NADP+
-
?
D-xylose + NADPH
-
Bos taurus ? + NADP+
-
?
D-xylose + NADPH
-
Canis lupus familiaris ? + NADP+
-
?
DL-glyceraldehyde + NADPH + H+
-
Canis lupus familiaris glycerol + NADP+
-
r
L-glyceraldehyde + NADPH
-
Cavia porcellus glycerol + NADP+
-
r
L-glyceraldehyde + NADPH
-
Mus musculus glycerol + NADP+
-
r
L-glyceraldehyde + NADPH
-
Homo sapiens glycerol + NADP+
-
r
L-glyceraldehyde + NADPH
-
Rattus norvegicus glycerol + NADP+
-
r
L-glyceraldehyde + NADPH
-
Sus scrofa glycerol + NADP+
-
r
L-glyceraldehyde + NADPH
-
Oryctolagus cuniculus glycerol + NADP+
-
r
L-glyceraldehyde + NADPH
-
Ovis aries glycerol + NADP+
-
r
L-glyceraldehyde + NADPH
-
Canis lupus familiaris glycerol + NADP+
-
r
additional information
-
Homo sapiens ?
-
?
additional information
-
Sus scrofa ?
-
?
additional information
-
Bos taurus ?
-
?
additional information D-hexose is no substrate Canis lupus familiaris ?
-
?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens
NADPH
-
Bos taurus
NADPH
-
Canis lupus familiaris