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Literature summary for 1.1.1.2 extracted from

  • Flynn, T.G.
    Aldehyde reductases: Monomeric NADPH-dependent oxidoreductases with multifunctional potential (1982), Biochem. Pharmacol., 31, 2705-2712.
    View publication on PubMed

Application

Application Comment Organism
medicine
-
Rattus norvegicus
medicine
-
Sus scrofa
medicine brain aldehyde reductase activity is closely associated with pharmalogical actions of drugs affecting the central nervous system, anti-convulsant drugs have inhibitory effects, more work is needed for the mechanism of action of psychoactive drugs and interactions of barbiturates with aldehyde reductase Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,3-dimethylsuccinic acid
-
Homo sapiens
2,3-dimethylsuccinic acid
-
Sus scrofa
Alrestatin
-
Homo sapiens
Alrestatin AY22,284A Rattus norvegicus
benzodiazepine
-
Homo sapiens
carbamazepine
-
Homo sapiens
EDTA lower molecular weight form Sus scrofa
p-mercuribenzoate
-
Homo sapiens
p-mercuribenzoate
-
Sus scrofa
phenacemide
-
Homo sapiens
Phenylmethylsulfonylfluoride lower molecular weight form Sus scrofa
Sodium barbitone
-
Sus scrofa
sodium valproate
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
cytosol
-
Rattus norvegicus 5829
-
cytosol
-
Oryctolagus cuniculus 5829
-
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
gel filtration, ultracentrifugation, specific activity corresponding to molecular weight Sus scrofa
28500
-
gel filtration, reductase I Sus scrofa
30200
-
ultracentrifugation Sus scrofa
33000
-
gel filtration Rattus norvegicus
33000
-
gel filtration Sus scrofa
35000
-
-
Homo sapiens
35000
-
liver enzyme, reductase II, gel filtration Sus scrofa
36000
-
gel filtration, low-Km reductase Sus scrofa
36700
-
1 * 36700, SDS-PAGE Sus scrofa
36900
-
1 * 36900, SDS-PAGE Sus scrofa
38000
-
1 * 38000, SDS-PAGE Sus scrofa
40200
-
SDS-PAGE Sus scrofa
41700
-
1 * 41700, SDS-PAGE Sus scrofa
43700
-
ultracentrifugation Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucuronate + NADPH Cavia porcellus
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Mus musculus
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Homo sapiens
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Rattus norvegicus
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Sus scrofa
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Oryctolagus cuniculus
-
L-gulonate + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Cavia porcellus
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Mus musculus
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Homo sapiens
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Sus scrofa
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Oryctolagus cuniculus
-
glycerol + NADP+
-
r
L-gulonic acid + NADP+ Rattus norvegicus
-
D-glucuronic acid + NADPH
-
r
L-gulonic acid + NADP+ Sus scrofa
-
D-glucuronic acid + NADPH
-
r
L-gulonic acid + NADP+ Oryctolagus cuniculus
-
D-glucuronic acid + NADPH
-
r
succinic semialdehyde + NADPH + H+ Homo sapiens
-
4-hydroxybutyrate + NADP+
-
r
succinic semialdehyde + NADPH + H+ Rattus norvegicus
-
4-hydroxybutyrate + NADP+
-
r
succinic semialdehyde + NADPH + H+ Sus scrofa
-
4-hydroxybutyrate + NADP+
-
r
succinic semialdehyde + NADPH + H+ Oryctolagus cuniculus
-
4-hydroxybutyrate + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
guinea pig
-
Drosophila melanogaster
-
fruit fly
-
Homo sapiens
-
human
-
Mus musculus
-
mouse
-
Oryctolagus cuniculus
-
rabbit
-
Rattus norvegicus
-
rat
-
Saccharomyces cerevisiae
-
yeast
-
Sus scrofa
-
pig
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Cavia porcellus
-
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Sus scrofa
-
brain
-
Oryctolagus cuniculus
-
kidney
-
Cavia porcellus
-
kidney
-
Mus musculus
-
kidney
-
Homo sapiens
-
kidney
-
Rattus norvegicus
-
kidney
-
Sus scrofa
-
kidney
-
Oryctolagus cuniculus
-
liver
-
Cavia porcellus
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Sus scrofa
-
liver
-
Oryctolagus cuniculus
-
muscle
-
Homo sapiens
-
muscle
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-pyridinecarboxaldehyde + NADPH
-
Cavia porcellus 3-pyridinemethanol + NADP+
-
r
3-pyridinecarboxaldehyde + NADPH
-
Homo sapiens 3-pyridinemethanol + NADP+
-
r
3-pyridinecarboxaldehyde + NADPH
-
Rattus norvegicus 3-pyridinemethanol + NADP+
-
r
3-pyridinecarboxaldehyde + NADPH
-
Sus scrofa 3-pyridinemethanol + NADP+
-
r
3-pyridinecarboxaldehyde + NADPH
-
Oryctolagus cuniculus 3-pyridinemethanol + NADP+
-
r
D-glucuronate + NADPH
-
Cavia porcellus L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Cavia porcellus L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Mus musculus L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Mus musculus L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Sus scrofa L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Sus scrofa L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Oryctolagus cuniculus L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Oryctolagus cuniculus L-gulonate + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Cavia porcellus glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Mus musculus glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Rattus norvegicus glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Sus scrofa glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Oryctolagus cuniculus glycerol + NADP+
-
r
L-gulonic acid + NADP+
-
Rattus norvegicus D-glucuronic acid + NADPH
-
r
L-gulonic acid + NADP+
-
Sus scrofa D-glucuronic acid + NADPH
-
r
L-gulonic acid + NADP+
-
Oryctolagus cuniculus D-glucuronic acid + NADPH
-
r
L-gulonic acid + NADPH
-
Rattus norvegicus D-glucuronic acid + NADP+
-
r
L-gulonic acid + NADPH
-
Sus scrofa D-glucuronic acid + NADP+
-
r
L-gulonic acid + NADPH
-
Oryctolagus cuniculus D-glucuronic acid + NADP+
-
r
p-carboxybenzaldehyde + NADPH
-
Homo sapiens p-carboxybenzyl alcohol + NADP+
-
r
p-carboxybenzaldehyde + NADPH
-
Rattus norvegicus p-carboxybenzyl alcohol + NADP+
-
r
p-carboxybenzaldehyde + NADPH
-
Sus scrofa p-carboxybenzyl alcohol + NADP+
-
r
p-nitrobenzaldehyde + NADPH
-
Homo sapiens p-nitrobenzylalcohol + NADP+
-
r
p-nitrobenzaldehyde + NADPH
-
Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
r
p-nitrobenzaldehyde + NADPH
-
Sus scrofa p-nitrobenzylalcohol + NADP+
-
r
p-nitrobenzaldehyde + NADPH
-
Oryctolagus cuniculus p-nitrobenzylalcohol + NADP+
-
r
succinic semialdehyde + NADPH + H+
-
Homo sapiens 4-hydroxybutyrate + NADP+
-
r
succinic semialdehyde + NADPH + H+
-
Rattus norvegicus 4-hydroxybutyrate + NADP+
-
r
succinic semialdehyde + NADPH + H+
-
Sus scrofa 4-hydroxybutyrate + NADP+
-
r
succinic semialdehyde + NADPH + H+
-
Oryctolagus cuniculus 4-hydroxybutyrate + NADP+
-
r

Subunits

Subunits Comment Organism
monomer
-
Homo sapiens
monomer
-
Rattus norvegicus
monomer
-
Saccharomyces cerevisiae
monomer 1 * 38000, SDS-PAGE Sus scrofa
monomer 1 * 36700, SDS-PAGE Sus scrofa
monomer 1 * 40200, SDS-PAGE Sus scrofa
monomer 1 * 36900, SDS-PAGE Sus scrofa
monomer 1 * 41700, SDS-PAGE Sus scrofa

Synonyms

Synonyms Comment Organism
daunorubicin reductase
-
Rattus norvegicus
daunorubicin reductase
-
Sus scrofa
L-hexonate dehydrogenase
-
Mus musculus
L-hexonate dehydrogenase
-
Homo sapiens