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Literature summary for 1.1.1.2 extracted from

  • Branlant, G.M; Biellmann, J.F.
    Purification and some properties of aldehyde reductases from pig liver (1980), Eur. J. Biochem., 105, 611-621.
    View publication on PubMed

Application

Application Comment Organism
medicine
-
Rattus norvegicus
medicine daunorubicin, a cancer chemotherapeutic agent can be reduced by aldehyde reductase Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Sus scrofa
2-mercaptoethanol
-
Sus scrofa
NADPH competitive inhibitor for reductase I Sus scrofa
Phenobarbital
-
Rattus norvegicus
Phenobarbital
-
Sus scrofa
pyrazole
-
Equus sp.
pyrazole
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0056
-
NADPH
-
Sus scrofa
0.008
-
NADPH
-
Sus scrofa
0.05
-
p-Carboxybenzaldehyde
-
Sus scrofa
0.08
-
daunorubicin reductase I Sus scrofa
0.1
-
4-Carboxyphenylglyoxal
-
Sus scrofa
0.1
-
Succinic semialdehyde reductase I Sus scrofa
0.27
-
p-nitrobenzaldehyde
-
Sus scrofa
0.6
-
indolacetaldehyde
-
Sus scrofa
1.2
-
Phenylglyoxal
-
Sus scrofa
1.5
-
D-glucuronate
-
Sus scrofa
1.5
-
3-Pyridinecarboxaldehyde
-
Sus scrofa
1.6
-
4-Carboxyacetophenone
-
Sus scrofa
2
-
2-chloroheptanal
-
Sus scrofa
4.5
-
D-glyceraldehyde
-
Sus scrofa
10
-
Heptanal
-
Sus scrofa
10
-
p-nitroacetophenone
-
Sus scrofa
14
-
butane 2,3-dione
-
Sus scrofa
150
-
n-Butyraldehyde
-
Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
liver enzyme, aldehyde reductase I, gel filtration Sus scrofa
35000
-
liver enzyme, reductase II, gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucuronate + NADPH Mus musculus
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Rattus norvegicus
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Sus scrofa
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Ovis aries
-
L-gulonate + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Mus musculus
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Sus scrofa
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Ovis aries
-
glycerol + NADP+
-
r
L-gulonic acid + NADP+ Rattus norvegicus
-
D-glucuronic acid + NADPH
-
r
L-gulonic acid + NADP+ Sus scrofa
-
D-glucuronic acid + NADPH
-
r
succinic semialdehyde + NADPH + H+ Rattus norvegicus
-
4-hydroxybutyrate + NADP+
-
r
succinic semialdehyde + NADPH + H+ Sus scrofa
-
4-hydroxybutyrate + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Equus sp.
-
horse
-
Mus musculus
-
mouse
-
Ovis aries
-
sheep
-
Ovis aries
-
Suffolk-Hampshire
-
Rattus norvegicus
-
rat
-
Sus scrofa
-
pig
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus
aldehyde reductase I Ovis aries
aldehyde reductase I and II from brain, no recuctase II activity could be detected in pig kidney Sus scrofa
reductase I Equus sp.

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Rattus norvegicus
-
brain
-
Sus scrofa
-
brain
-
Ovis aries
-
kidney
-
Mus musculus
-
kidney
-
Rattus norvegicus
-
kidney
-
Sus scrofa
-
kidney
-
Ovis aries
-
liver
-
Mus musculus
-
liver
-
Rattus norvegicus
-
liver
-
Sus scrofa
-
liver
-
Ovis aries
-
liver
-
Equus sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
35
-
-
Sus scrofa

Storage Stability

Storage Stability Organism
-20°C, stable for several months if stored as an ammonium sulfate precipitate Sus scrofa
20°C reductase I stable for more than 1 month Sus scrofa
4°C reductase I and II are stable for several months Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-chloroheptanal + NADPH
-
Sus scrofa 2-chloroheptanol + NADP+
-
r
3-pyridinecarboxaldehyde + NADPH
-
Rattus norvegicus 3-pyridinemethanol + NADP+
-
r
3-pyridinecarboxaldehyde + NADPH
-
Sus scrofa 3-pyridinemethanol + NADP+
-
r
3-pyridinecarboxaldehyde + NADPH
-
Ovis aries 3-pyridinemethanol + NADP+
-
r
4-carboxyacetophenone + NADPH
-
Sus scrofa ? + NADP+
-
r
4-carboxyphenylglyoxal + NADPH
-
Sus scrofa ? + NADP+
-
r
benzyl alcohol + NADP+
-
Sus scrofa benzaldehyde + NADPH
-
r
butane 2,3-dione + NADPH
-
Sus scrofa ? + NADP+
-
r
D-glucuronate + NADPH
-
Mus musculus L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Mus musculus L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Sus scrofa L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Sus scrofa L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Ovis aries L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Ovis aries L-gulonate + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Mus musculus glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Rattus norvegicus glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Sus scrofa glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Ovis aries glycerol + NADP+
-
r
daunorubicin + NADPH
-
Rattus norvegicus ? + NADP+
-
?
daunorubicin + NADPH
-
Sus scrofa ? + NADP+
-
?
indol-3-ylacetaldehyde + NADPH
-
Sus scrofa indol-3-ethanol + NADP+
-
?
indolacetaldehyde + NADPH
-
Sus scrofa ? + NADP+
-
?
L-gulonic acid + NADP+
-
Rattus norvegicus D-glucuronic acid + NADPH
-
r
L-gulonic acid + NADP+
-
Sus scrofa D-glucuronic acid + NADPH
-
r
L-gulonic acid + NADPH
-
Rattus norvegicus D-glucuronic acid + NADP+
-
r
L-gulonic acid + NADPH
-
Sus scrofa D-glucuronic acid + NADP+
-
r
n-butyraldehyde + NADPH
-
Sus scrofa n-butanol + NADP+
-
?
n-heptanal + NADPH
-
Sus scrofa heptanol + NADP+
-
r
p-carboxybenzaldehyde + NADPH
-
Rattus norvegicus p-carboxybenzyl alcohol + NADP+
-
r
p-carboxybenzaldehyde + NADPH
-
Sus scrofa p-carboxybenzyl alcohol + NADP+
-
r
p-nitroacetophenone + NADPH
-
Sus scrofa ? + NADP+
-
r
p-nitrobenzaldehyde + NADPH
-
Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
r
p-nitrobenzaldehyde + NADPH
-
Sus scrofa p-nitrobenzylalcohol + NADP+
-
r
p-nitrobenzaldehyde + NADPH
-
Ovis aries p-nitrobenzylalcohol + NADP+
-
r
phenylglyoxal + NADPH
-
Sus scrofa ? + NADP+
-
r
succinic semialdehyde + NADPH + H+
-
Rattus norvegicus 4-hydroxybutyrate + NADP+
-
r
succinic semialdehyde + NADPH + H+
-
Sus scrofa 4-hydroxybutyrate + NADP+
-
r

Subunits

Subunits Comment Organism
monomer
-
Rattus norvegicus
monomer 1 * 35000 Sus scrofa

Synonyms

Synonyms Comment Organism
liver alcohol dehydrogenase
-
Equus sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.9
-
aldehyde reductase I Sus scrofa
6.2
-
aldehyde reductase II Sus scrofa