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Literature summary for 1.1.1.184 extracted from

  • Kandeel, M.; Al-Taher, A.; Al-Nazawi, M.; Ohhashi, K.
    Substructural dynamics of the phase-I drug metabolizing enzyme, carbonyl reductase 1, in response to various substrate and inhibitor configurations (2019), Trop. J. Pharm. Res., 18, 1635-1641 .
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
7-hydroxyethylrutoside
-
Homo sapiens
Barbital 18% inhibition at 1 mM Homo sapiens
Biochanin A
-
Homo sapiens
rutoside
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-nitrobenzaldehyde + NADPH + H+ Homo sapiens
-
4-nitrobenzylalcohol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P16152
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-butanedione + NADPH + H+
-
Homo sapiens ?
-
?
4-nitrobenzaldehyde + NADPH + H+
-
Homo sapiens 4-nitrobenzylalcohol + NADP+
-
?
doxorubicin + NADPH + H+
-
Homo sapiens doxorubicinol + NADP+
-
?
menadione + NADPH + H+
-
Homo sapiens ?
-
?
mitroxantrone + NADPH + H+
-
Homo sapiens ?
-
?
oracin + NADPH + H+
-
Homo sapiens 11-dihydrooracin + NADP+
-
?
prostaglandin E2 + NADPH + H+
-
Homo sapiens prostaglandin F2alpha + NADP+
-
?

Synonyms

Synonyms Comment Organism
carbonyl reductase 1
-
Homo sapiens
CBR1
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00203
-
Biochanin A pH and temperature not specified in the publication Homo sapiens
0.033
-
rutoside pH and temperature not specified in the publication Homo sapiens