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Literature summary for 1.1.1.184 extracted from

  • Morgan, R.A.; Beck, K.R.; Nixon, M.; Homer, N.Z.M.; Crawford, A.A.; Melchers, D.; Houtman, R.; Meijer, O.C.; Stomby, A.; Anderson, A.J.; Upreti, R.; Stimson, R.H.; Olsson, T.; Michoel, T.; Cohain, A.; Ruusalepp, A.; Schadt, E.E.; Bjoerkegren, J.L.M.; Andrew, R.; Kenyon, C.J.; Hadoke, P.W.F.; Odermatt, A.; Keen, J.
    Carbonyl reductase 1 catalyzes 20beta-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity (2017), Sci. Rep., 7, 10633 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
quercetin
-
Equus caballus
quercetin
-
Homo sapiens
quercetin
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisol + NADPH + H+ Equus caballus
-
20beta-dihydrocortisol + NADP+
-
?
cortisol + NADPH + H+ Homo sapiens
-
20beta-dihydrocortisol + NADP+
-
?
cortisol + NADPH + H+ Mus musculus
-
20beta-dihydrocortisol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Equus caballus
-
-
-
Homo sapiens P16152
-
-
Mus musculus P48758
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Equus caballus
-
adipose tissue
-
Homo sapiens
-
adipose tissue
-
Mus musculus
-
gut
-
Equus caballus
-
gut
-
Mus musculus
-
kidney
-
Equus caballus
-
kidney
-
Mus musculus
-
liver
-
Equus caballus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NADPH + H+
-
Equus caballus 20beta-dihydrocortisol + NADP+
-
?
cortisol + NADPH + H+
-
Homo sapiens 20beta-dihydrocortisol + NADP+
-
?
cortisol + NADPH + H+
-
Mus musculus 20beta-dihydrocortisol + NADP+
-
?

Synonyms

Synonyms Comment Organism
carbonyl reductase 1
-
Equus caballus
carbonyl reductase 1
-
Homo sapiens
carbonyl reductase 1
-
Mus musculus
CBR1
-
Equus caballus
CBR1
-
Homo sapiens
CBR1
-
Mus musculus

Expression

Organism Comment Expression
Equus caballus the enzyme is up-regulated in adipose tissue in obesity up
Homo sapiens the enzyme is up-regulated in adipose tissue in obesity up
Mus musculus the enzyme is up-regulated in adipose tissue in obesity up

General Information

General Information Comment Organism
malfunction pharmacological inhibition of carbonyl reductase 1 in diet-induced obesity in mice results in more marked glucose intolerance with evidence for enhanced hepatic glucocorticoid receptor signaling Mus musculus
metabolism carbonyl reductase 1 generating 20beta-dihydrocortisol is a pathway modulating glucocorticoid receptor activation and providing enzymatic protection against excessive GR activation in obesity Equus caballus
metabolism carbonyl reductase 1 generating 20beta-dihydrocortisol is a pathway modulating glucocorticoid receptor activation and providing enzymatic protection against excessive GR activation in obesity Homo sapiens
metabolism carbonyl reductase 1 generating 20beta-dihydrocortisol is a pathway modulating glucocorticoid receptor activation and providing enzymatic protection against excessive GR activation in obesity Mus musculus