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Literature summary for 1.1.1.146 extracted from

  • Lee, N.R.; Kim, B.J.; Lee, C.H.; Lee, Y.B.; Lee, S.; Hwang, H.J.; Kim, E.; Kim, S.H.; Lee, M.G.; Lee, S.E.; Lavery, G.G.; Choi, E.H.
    Role of 11beta-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis (2020), Sci. Rep., 10, 20237 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3-dihydrospiro[indene-1,4'-piperidin]-3-yl)acetic acid selective isoform 11beta-HSD1 inhibitor Homo sapiens
(1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3-dihydrospiro[indene-1,4'-piperidin]-3-yl)acetic acid selective isoform 11beta-HSD1 inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisone + NADPH + H+ Homo sapiens
-
cortisol + NADP+
-
?
cortisone + NADPH + H+ Mus musculus
-
cortisol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P28845
-
-
Mus musculus P50172
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
Homo sapiens
-
epidermis
-
Mus musculus
-
keratinocyte
-
Homo sapiens
-
NHEK cell
-
Homo sapiens
-
skin
-
Homo sapiens
-
skin
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisone + NADPH + H+
-
Homo sapiens cortisol + NADP+
-
?
cortisone + NADPH + H+
-
Mus musculus cortisol + NADP+
-
?

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
Homo sapiens
11beta-HSD1
-
Mus musculus
11beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1
-
Mus musculus

Expression

Organism Comment Expression
Homo sapiens epidermal isoform 11beta-HSD1 expression is decreased in the lesional skin of patients with atopic dermatitis down
Mus musculus the expression of isoform 11beta-HSD1 in the epidermis of atopic dermatitis lesions is higher than that in the epidermis of healthy controls up

General Information

General Information Comment Organism
malfunction inhibition of isoform 11beta-HSD1 aggravates the development of atopic dermatitis and increases serum cytokine levels associated with atopic dermatitis. Mice with whole-body knockout of11beta-HSD1 develop significantly worse atopic dermatitis upon induction by oxazolone Mus musculus
physiological function isoform 11beta-HSD1 is a major factor affecting atopic dermatitis pathophysiology via suppression of atopic inflammation due to the modulation of active glucocorticoid in the skin Homo sapiens
physiological function isoform 11beta-HSD1 is a major factor affecting atopic dermatitis pathophysiology via suppression of atopic inflammation due to the modulation of active glucocorticoid in the skin Mus musculus