Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3-dihydrospiro[indene-1,4'-piperidin]-3-yl)acetic acid | selective isoform 11beta-HSD1 inhibitor | Homo sapiens | |
(1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3-dihydrospiro[indene-1,4'-piperidin]-3-yl)acetic acid | selective isoform 11beta-HSD1 inhibitor | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | Homo sapiens | - |
cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | Mus musculus | - |
cortisol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Mus musculus | P50172 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | - |
Homo sapiens | - |
epidermis | - |
Mus musculus | - |
keratinocyte | - |
Homo sapiens | - |
NHEK cell | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
skin | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Mus musculus | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-HSD1 | - |
Mus musculus |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | epidermal isoform 11beta-HSD1 expression is decreased in the lesional skin of patients with atopic dermatitis | down |
Mus musculus | the expression of isoform 11beta-HSD1 in the epidermis of atopic dermatitis lesions is higher than that in the epidermis of healthy controls | up |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of isoform 11beta-HSD1 aggravates the development of atopic dermatitis and increases serum cytokine levels associated with atopic dermatitis. Mice with whole-body knockout of11beta-HSD1 develop significantly worse atopic dermatitis upon induction by oxazolone | Mus musculus |
physiological function | isoform 11beta-HSD1 is a major factor affecting atopic dermatitis pathophysiology via suppression of atopic inflammation due to the modulation of active glucocorticoid in the skin | Homo sapiens |
physiological function | isoform 11beta-HSD1 is a major factor affecting atopic dermatitis pathophysiology via suppression of atopic inflammation due to the modulation of active glucocorticoid in the skin | Mus musculus |