Literature summary for 1.1.1.146 extracted from

Vitku, J.; Starka, L.; Bicikova, M.; Hill, M.; Heracek, J.; Sosvorova, L.; Hampl, R.
Endocrine disruptors and other inhibitors of 11beta-hydroxysteroid dehydrogenase 1 and 2: Tissue-specific consequences of enzyme inhibition (2016), J. Steroid Biochem. Mol. Biol., 155, 207-216.

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Inhibitors

Inhibitors	Comment	Organism
(1E,4E)-1,5-bis(3-methylthiophen-2-yl)penta-1,4-dien-3-one	-	Homo sapiens
(1E,4E)-1,5-bis(thiophen-2-yl)cyclohexanone	-	Homo sapiens
(1E,4E)-1,5-bis(thiophen-2-yl)penta-1,4-dien-3-one	-	Homo sapiens
(20R,23E)-eupha-8,23-diene-3beta,25-diol	-	Homo sapiens
(24R)-eupha-8,25-diene-3beta,24-diol	-	Homo sapiens
2'-hydroxyflavanone	-	Homo sapiens
2,2'-Dihydroxybiphenyl	-	Homo sapiens
2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane	-	Homo sapiens
3-methylchrysazin	-	Homo sapiens
4'-hydroxyflavanone	-	Homo sapiens
4-n-nonylphenol	-	Homo sapiens
4-n-octylphenol	-	Homo sapiens
4-nonylphenol	-	Homo sapiens
4-tert-octylphenol	-	Homo sapiens
6-hydroxyflavanone	-	Homo sapiens
abietic acid	-	Homo sapiens
aloe emodin	-	Homo sapiens
bisphenol A	-	Homo sapiens
carbenoxolone	-	Homo sapiens
curcumin	-	Homo sapiens
di-n-butyl phthalate	-	Homo sapiens
dibenzoylmethane	-	Homo sapiens
dibutyltin	-	Homo sapiens
dicyclohexyl benzene-1,2-dicarboxylate	-	Homo sapiens
diethylhexyl adipate	-	Homo sapiens
diphenyltin	-	Homo sapiens
dipropyl phthalate	-	Homo sapiens
Disulfiram	-	Homo sapiens
emodin	-	Homo sapiens
endosulfan	-	Homo sapiens
epigallocatechine-3-gallate	-	Homo sapiens
euphane-3beta,20-dihydroxy-24-ene	-	Homo sapiens
flavanone	-	Homo sapiens
Fusidic acid	-	Homo sapiens
glycyrrhetinic acid	-	Homo sapiens
kansenone	-	Homo sapiens
kansuinone	-	Homo sapiens
maneb	-	Homo sapiens
methoxychlor	-	Homo sapiens
methyl jasmonate	-	Homo sapiens
mono(2-ethylhexyl)phthalate	-	Homo sapiens
perfluorohexanesulfonate	-	Homo sapiens
Perfluorooctanoic acid	-	Homo sapiens
perfluorooctyl sulfonate	-	Homo sapiens
pyrrolidine dithiocarbamate	-	Homo sapiens
resveratrol	-	Homo sapiens
rheochrysidin	-	Homo sapiens
thiram	-	Homo sapiens
tributyltin	-	Homo sapiens
Triphenyltin	-	Homo sapiens
zearalenone	-	Homo sapiens
zineb	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cortisol + NADP+	Homo sapiens	-	cortisone + NADPH + H+	-	r
cortisone + NADPH + H+	Homo sapiens	-	cortisol + NADP+	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipose tissue	-	Homo sapiens	-
brain	-	Homo sapiens	-
colon	-	Homo sapiens	-
kidney	-	Homo sapiens	-
placenta	-	Homo sapiens	-
testis	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cortisol + NADP+	-	Homo sapiens	cortisone + NADPH + H+	-	r
cortisone + NADPH + H+	-	Homo sapiens	cortisol + NADP+	-	r

Synonyms

Synonyms	Comment	Organism
11beta-hydroxysteroid dehydrogenase	-	Homo sapiens
11betaHSD1	isoform	Homo sapiens
11betaHSD2	isoform	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Homo sapiens
NADPH	-	Homo sapiens