Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-piperidinecarboxylic acid | - |
Homo sapiens | |
11-ketotestosterone | - |
Homo sapiens | |
2'-hydroxyflavanone | - |
Homo sapiens | |
4'-hydroxyflavanone | - |
Homo sapiens | |
abietic acid | weak inhibition | Homo sapiens | |
benzenesulfonamide | - |
Homo sapiens | |
BVT-14225 | - |
Homo sapiens | |
BVT-2733 | - |
Homo sapiens | |
chenodeoxycholic acid | - |
Homo sapiens | |
Cyclobutanone | - |
Homo sapiens | |
ethanone | - |
Homo sapiens | |
flavanone | - |
Homo sapiens | |
indinavir | - |
Homo sapiens | |
methyl {(1S,2S)-3-oxo-2-[(2Z)-pent-2-en-1-yl]cyclopentyl}acetate | weak inhibition | Homo sapiens | |
additional information | no inhibition by DETC, flavone, and bisphenol A, molecular docking and modeling of enzyme-inhibitor interactions the model can discriminate between known isozyme 11beta-HSD1 inhibitors or substrates and non-inhibitors, inhibitroy binding mode, overview | Homo sapiens | |
NSC 112288 | - |
Homo sapiens | |
NSC 56412 | - |
Homo sapiens | |
NSC 75617 | - |
Homo sapiens | |
resorcinol | weak inhibition | Homo sapiens | |
rosiglitazone | - |
Homo sapiens | |
saquinavir | - |
Homo sapiens | |
TZD 2 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | Homo sapiens | isozyme 11beta-HSD1 | cortisol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme 11betaHSD1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
15-deoxy-D12,14-prostaglandin J2 + NADPH | isozyme 11beta-HSD1 | Homo sapiens | ? | - |
? | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1 | Homo sapiens | cortisol + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | homology modeling and analysis of three-dimensional structure models from crystal structures, model validation, detailed overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
11betaHSD1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |