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Literature summary for 1.1.1.146 extracted from

  • McCormick, K.L.; Wang, X.; Mick, G.J.
    Evidence that the 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes (2006), J. Biol. Chem., 281, 341-347.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dehydroandrostenedione activates isozyme 11beta-HSD1 3fold Rattus norvegicus
norepinephrine activates isozyme 11beta-HSD1 2.5fold Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum intraluminal compartment Rattus norvegicus 5783
-
microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11-dehydrocorticosterone + NADPH Rattus norvegicus isozyme 11beta-HSD1, biological activation of the glucocorticoid corticosterone + NADP+
-
?
cortisone + NADPH + H+ Rattus norvegicus isozyme 11beta-HSD1, biological activation of the glucocorticoid cortisol + NADP+
-
?
additional information Rattus norvegicus isozyme 11beta-HSD1 is regulated by the pentose phosphate pathway flux, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
isozyme 11beta-HSD1
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
Rattus norvegicus
-
adipose tissue
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-dehydrocorticosterone + NADPH isozyme 11beta-HSD1 Rattus norvegicus corticosterone + NADP+
-
?
11-dehydrocorticosterone + NADPH isozyme 11beta-HSD1, biological activation of the glucocorticoid Rattus norvegicus corticosterone + NADP+
-
?
cortisone + NADPH + H+ isozyme 11beta-HSD1 Rattus norvegicus cortisol + NADP+
-
?
cortisone + NADPH + H+ isozyme 11beta-HSD1, biological activation of the glucocorticoid Rattus norvegicus cortisol + NADP+
-
?
additional information isozyme 11beta-HSD1 is regulated by the pentose phosphate pathway flux, overview Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
Rattus norvegicus
11beta-hydroxysteroid dehydrogenase type 1
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus