Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dehydroandrostenedione | activates isozyme 11beta-HSD1 3fold | Rattus norvegicus | |
norepinephrine | activates isozyme 11beta-HSD1 2.5fold | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | intraluminal compartment | Rattus norvegicus | 5783 | - |
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH | Rattus norvegicus | isozyme 11beta-HSD1, biological activation of the glucocorticoid | corticosterone + NADP+ | - |
? | |
cortisone + NADPH + H+ | Rattus norvegicus | isozyme 11beta-HSD1, biological activation of the glucocorticoid | cortisol + NADP+ | - |
? | |
additional information | Rattus norvegicus | isozyme 11beta-HSD1 is regulated by the pentose phosphate pathway flux, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
isozyme 11beta-HSD1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Rattus norvegicus | - |
adipose tissue | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Rattus norvegicus | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1, biological activation of the glucocorticoid | Rattus norvegicus | corticosterone + NADP+ | - |
? | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1 | Rattus norvegicus | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1, biological activation of the glucocorticoid | Rattus norvegicus | cortisol + NADP+ | - |
? | |
additional information | isozyme 11beta-HSD1 is regulated by the pentose phosphate pathway flux, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Rattus norvegicus |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |