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Literature summary for 1.1.1.146 extracted from

  • Gomez-Sanchez, E.P.; Venkataseshu, G.; Chen, Y.J.; Liu, Y.; Zhou, M.Y.; Toroslu, C.; Romero, D.G.; Hughson, M.D.; de Rodriguez, A.; Gomez-Sanchez, C.E.
    Regulation of 11beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol (2003), Am. J. Physiol. Endocrinol. Metab., 285, E272-E279.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
estradiol 50% inhibition, DTT protects at 10 mM, estradiol has a regulatory function on the isozymes in the liver Rattus norvegicus
additional information isozyme 11beta-HSD1 expression is about 30% reduced in castrated male rats, while expression of isozyme 11beta-HSD2 is increased, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisone + NADPH + H+ Rattus norvegicus isozyme 11beta-HSD1 prefers the reduction of cortisone cortisol + NADP+
-
r
additional information Rattus norvegicus estradiol has a regulatory function on the isozymes in the liver, isozyme 11beta-HSD1 expression is about 30% reduced in castrated male rats, while expression of isozyme 11beta-HSD2 is increased, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney isozyme expression patterns, overview Rattus norvegicus
-
additional information isozyme 11beta-HSD1 expression is about 30% reduced in castrated male rats, while expression of isozyme 11beta-HSD2 is increased, overview Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
isozyme expression, and isozyme and cofactor specific activities in kidney microsomes, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisone + NADPH + H+ isozyme 11beta-HSD1 prefers the reduction of cortisone Rattus norvegicus cortisol + NADP+
-
r
additional information estradiol has a regulatory function on the isozymes in the liver, isozyme 11beta-HSD1 expression is about 30% reduced in castrated male rats, while expression of isozyme 11beta-HSD2 is increased, overview Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase 1
-
Rattus norvegicus
11betaHSD1
-
Rattus norvegicus
NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Rattus norvegicus
NADPH
-
Rattus norvegicus