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Literature summary for 1.1.1.146 extracted from

  • Blum, A.; Maser, E.
    The critical role of the N-terminus of 11beta-hydroxysteroid dehydrogenase type 1, as being encoded by exon 1, for enzyme stabilization and activity (2003), Chem. Biol. Interact., 143-144, 469-480.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli and Pichia pastoris Homo sapiens

Protein Variants

Protein Variants Comment Organism
V149E no change in activity compared to wild-type Homo sapiens
V149R no change in activity compared to wild-type Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
membrane membrane bound enzyme with the catalytic domain localized in the lumen of the ER Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisone + NADPH + H+ Homo sapiens
-
cortisol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisone + NADPH + H+
-
Homo sapiens cortisol + NADP+
-
?

Synonyms

Synonyms Comment Organism
11beta-HSD 1
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens