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Literature summary for 1.1.1.100 extracted from

  • Rosado, L.A.; Caceres, R.A.; de Azevedo, W.F.; Basso, L.A.; Santos, D.S.
    Role of Serine140 in the mode of action of Mycobacterium tuberculosis beta-ketoacyl-ACP Reductase (MabA) (2012), BMC Res. Notes, 5, 526.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
S140A mutant shows no enzymatic activity. S140A mutant does not bind to NADPH Mycobacterium tuberculosis
S140T mutant shows no enzymatic activity. Mutant S140T shows impaired NADPH binding Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetoacetyl-CoA + NADPH + H+
-
Mycobacterium tuberculosis D-3-hydroxybutyryl-CoA + NADP+
-
?

Synonyms

Synonyms Comment Organism
beta-ketoacyl-ACP reductase
-
Mycobacterium tuberculosis
MabA
-
Mycobacterium tuberculosis

Temperature Optimum [┬░C]

Temperature Optimum [┬░C] Temperature Optimum Maximum [┬░C] Comment Organism
25
-
assay at Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Mycobacterium tuberculosis