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Literature summary for 1.1.1.10 extracted from

  • Carbone, V.; Darmanin, C.; Ishikura, S.; Hara, A.; El-Kabbani, O.
    Structure-based design of inhibitors of human L-xylulose reductase modelled into the active site of the enzyme (2003), Bioorg. Med. Chem. Lett., 13, 1469-1474.
    View publication on PubMed

Application

Application Comment Organism
pharmacology enzyme is a target for design and development of potent and specific structure-based inhibitors binding in the active site Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information modelling of structure-based inhibitor binding into the active site Homo sapiens
n-butyric acid binds to the active site of the enzyme, complex structure determination and analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
brush border
-
Homo sapiens 5903
-
membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-xylulose + NADPH + H+ Homo sapiens part of the glucuronic acid pathway, enzyme may be involved in water reabsorption and cellular osmoregulation L-xylitol + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
xylitol + NADP+ = L-xylulose + NADPH + H+ active site structure Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-xylulose + NADPH + H+
-
Homo sapiens L-xylitol + NADP+
-
r
L-xylulose + NADPH + H+ part of the glucuronic acid pathway, enzyme may be involved in water reabsorption and cellular osmoregulation Homo sapiens L-xylitol + NADP+
-
r

Synonyms

Synonyms Comment Organism
XR
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens