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Literature summary for 1.1.1.1 extracted from
- Oxidative bioactivation of crotyl alcohol to the toxic endogenous aldehyde crotonaldehyde: association of protein carbonylation with toxicity in mouse hepatocytes (2002), Chem. Res. Toxicol., 15, 1051-1058.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-Methylpyrazole | - |
Equus caballus |  |
| 4-Methylpyrazole | inhibits cell protein carbonylation following exposure to crotyl alcohol | Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Equus caballus | |
| 0.39 | - |
allyl alcohol | pH 7.3, 37°C | Equus caballus | |
| 0.71 | - |
crotyl alcohol | pH 7.3, 37°C | Equus caballus | |
| 2.46 | - |
ethanol | pH 7.3, 37°C | Equus caballus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Mus musculus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| allyl alcohol + NAD+ | Mus musculus | - |
acrolein + NADH | product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol | ? | |
| crotyl alcohol + NAD+ | Mus musculus | - |
crotonaldehyde + NADH | product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol | ? | |
| crotyl alcohol + NAD+ | Equus caballus | product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol | crotonaldehyde + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Equus caballus | - |
- |
- |
| Mus musculus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| a primary alcohol + NAD+ = an aldehyde + NADH + H+ | ordered sequential bibi reaction mechanism, modeling of oxidation kinetic mechanism | Equus caballus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Equus caballus | - |
| hepatocyte | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Equus caballus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| allyl alcohol + NAD+ | - |
Mus musculus | acrolein + NADH | - |
? | |
| allyl alcohol + NAD+ | - |
Equus caballus | acrolein + NADH | - |
? | |
| allyl alcohol + NAD+ | - |
Mus musculus | acrolein + NADH | product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol | ? | |
| crotyl alcohol + NAD+ | - |
Mus musculus | crotonaldehyde + NADH | - |
? | |
| crotyl alcohol + NAD+ | - |
Equus caballus | crotonaldehyde + NADH | - |
? | |
| crotyl alcohol + NAD+ | - |
Mus musculus | crotonaldehyde + NADH | product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol | ? | |
| crotyl alcohol + NAD+ | product is toxic in mouse hepatocytes due to cell protein carbonylation following exposure to crotyl alcohol | Equus caballus | crotonaldehyde + NADH | - |
? | |
| ethanol + NAD+ | - |
Equus caballus | acetaldehyde + NADH | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADH | - |
Mus musculus |
| ADH | - |
Equus caballus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Equus caballus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | - |
assay at | Equus caballus |
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