Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate .
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate [2].
the enzyme is involved in the biosynthesis of the vitamin E, tocotrienols. It uses primarily geranylgeranyl diphosphate as a substrate, but is capable of generating the 2-methyl-6-phytylbenzoquinol precursor of tocopherols, particularly in the presence of elevated ratios of phytyl diphosphate:geranylgeranyl diphosphate
the enzyme is six times more active (Vmax) with geranylgeranyl diphosphate than with phytyl diphosphate. Small difference in Km-value of geranylgeranyl diphosphate and phytyl diphosphate
the enzyme is involved in the biosynthesis of the vitamin E, tocotrienols. It uses primarily geranylgeranyl diphosphate as a substrate, but is capable of generating the 2-methyl-6-phytylbenzoquinol precursor of tocopherols, particularly in the presence of elevated ratios of phytyl diphosphate:geranylgeranyl diphosphate
the enzyme is six times more active (Vmax) with geranylgeranyl diphosphate than with phytyl diphosphate. Small difference in Km-value of geranylgeranyl diphosphate and phytyl diphosphate
the enzyme is involved in the biosynthesis of the vitamin E, tocotrienols. It uses primarily geranylgeranyl diphosphate as a substrate, but is capable of generating the 2-methyl-6-phytylbenzoquinol precursor of tocopherols, particularly in the presence of elevated ratios of phytyl diphosphate:geranylgeranyl diphosphate
the enzyme is involved in the biosynthesis of the vitamin E, tocotrienols. It uses primarily geranylgeranyl diphosphate as a substrate, but is capable of generating the 2-methyl-6-phytylbenzoquinol precursor of tocopherols, particularly in the presence of elevated ratios of phytyl diphosphate:geranylgeranyl diphosphate
genotype G37 (red pericarp) shows higher expression than G7 (light brown) and G33 (red pericarp) at milky and mature grain development stages but lower than both parents. The transcript levels are comparatively low in mature grain
combined expression of hydroxyphenylpyruvate dioxygenase/bi-functional chorismate mutase/prephenate dehydrogenase and homogentisate geranylgeranyl transferase in Arabidopsis leaves and seeds results in large additive increases in vitamin E production, indicating that homogentisate concentrations limit homogentisate geranylgeranyl transferase-catalyzed tocotrienol synthesis
SLR1736 gene disruption does not lead to significant differences in cellular plastoquinone, phylloquinone, and chlorophyll levels, but causes absence of tocopherols without affecting plastoquinone-9 levels
transgenic expression of the barley homogentisic acid geranylgeranyl transferase in Arabidopsis thaliana leaves results in accumulation of tocotrienols, which are absent from leaves of nontransformed plants, and a 10- to 15fold increase in total tocotrienols plus tocopherols. Overexpression of the barley enzyme in corn seeds results in an increase in tocotrienol and tocopherol content of as much as 6fold
tocotrienol precursors such as homogentisate and geranylgeranyl diphosphate decrease during maturation of the grain. HGGT is an essential, but not limiting factor for tocotrienol biosynthesis, and tocotrienol precursors can regulate the tocotrienol level in grain
combined expression of hydroxyphenylpyruvate dioxygenase/bi-functional chorismate mutase/prephenate dehydrogenase and homogentisate geranylgeranyl transferase in Arabidopsis leaves and seeds results in large additive increases in vitamin E production, indicating that homogentisate concentrations limit homogentisate geranylgeranyl transferase-catalyzed tocotrienol synthesis
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression analysis of HGGT in a set of contrasting red pericarp and light brown rice genotypes of advanced breeding lines together with their parents. Genotype G37 (red pericarp) shows higher expression than G7 (light brown) and G33 (red pericarp) at milky and mature grain development stages but lower than both parents. The transcript levels are comparatively low in mature grain
tocochromanol analysis in a set of contrasting red pericarp and light brown rice genotypes of advanced breeding lines together with their parents. The content of tocochromaols decreases in the order gamma-tocotrienol, alpha-tocopherol, alpha-tocotrienol, gamma-tocopherol, delta-tocotrienol, and total E vitamin content ranges from 10.30 to 31.65 microg/g