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Disease on EC 2.4.2.30 - NAD+ ADP-ribosyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
miR-520 promotes DNA-damage-induced trophoblast cell apoptosis by targeting PARP1 in recurrent spontaneous abortion (RSA).
Acidosis
Activation of poly(ADP-ribose) polymerase in severe hemorrhagic shock and resuscitation.
Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis.
Inhibitory effects of glibenclamide and pertussis toxin on the attenuation of ischemia-induced myocardial acidosis following ischemic preconditioning in dogs.
Acquired Immunodeficiency Syndrome
Damage and repair of DNA in HIV encephalitis.
Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents.
Acute Kidney Injury
5-aminoisoquinoline improves renal function and fibrosis during recovery phase of cisplatin-induced acute kidney injury in rats.
Effect of poly(ADP-ribose) polymerase inhibition on outer medullary hypoxic damage.
Inhibition of PARP overactivation protects acute kidney injury of septic shock.
Inhibition of Poly(ADP-Ribose) Polymerase Attenuates Acute Kidney Injury in Sodium Taurocholate-Induced Acute Pancreatitis in Rats.
Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats.
Inhibition of Poly-(ADP-Ribose) Polymerase Protects the Kidney in a Canine Model of Endotoxic Shock.
Poly (ADP-ribose) polymerase as a potential target for the treatment of acute renal injury caused by lipopolysaccharide.
Poly(ADP-ribose) polymerase 1 activation links ischemic acute kidney injury to interstitial fibrosis.
Poly(ADP-ribose) polymerase-1 gene ablation protects mice from ischemic renal injury.
Poly(ADP-ribose) polymerase-mediated cell injury in acute renal failure.
Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?
Role of poly (ADP-ribose) polymerase-1 and cytokines in acute renal injury in elderly Chinese patients with diabetes mellitus.
Role of the poly(ADP-ribose)polymerase activity in vancomycin-induced renal injury.
Acute Lung Injury
Administration of poly(ADP-ribose) polymerase inhibitor into bronchial artery attenuates pulmonary pathophysiology after smoke inhalation and burn in an ovine model.
Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury.
Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis.
Murine strain differences in acute lung injury and activation of poly(ADP-ribose) polymerase by in vitro exposure of lung slices to bleomycin.
Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice.
PARP inhibitor, olaparib ameliorates acute lung and kidney injury upon intratracheal administration of LPS in mice.
PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-?B-mediated inflammatory response.
Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib, prevents acute lung injury associated cognitive deficits potentially through suppression of inflammatory response.
Poly(ADP-ribose) Polymerase Inhibition in Acute Lung Injury: A Re-emerging Concept.
Role of PARP on iNOS pathway during endotoxin-induced acute lung injury.
The molecular mechanism of acute lung injury caused by Pseudomonas aeruginosa: from bacterial pathogenesis to host response.
The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice.
Adenocarcinoma
A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination-deficient Pancreatic Cancer.
Adenosine diphosphate ribosyl transferase and x-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer.
Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent mechanism.
Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells.
Antiproliferative and Proapoptotic Activities of Marine Sponge Hyrtios erectus Extract on Breast Carcinoma Cell Line (MCF-7).
BRCA2 secondary mutation-mediated resistance to platinum and PARP inhibitor-based therapy in pancreatic cancer.
Correlation between PARP-1 Val762Ala polymorphism and the risk of lung cancer in a Chinese population.
Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis.
Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer.
DNA Damage Repair Alterations are Frequent in Prostatic Adenocarcinomas with Focal Pleomorphic Giant Cell Features.
Dysregulation of PARP1 is involved in development of Barrett's esophagus.
Evaluation of apoptosis induction using PARP cleavage on gastric adenocarcinoma and fibroblast cell lines by different strains of Helicobacter pylori.
Expression of poly-ADP-ribose polymerase (PARP) in endometrial adenocarcinoma: Prognostic potential.
High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer.
HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells.
Hypomethylation of ETS transcription factor binding sites and upregulation of PARP1 expression in endometrial cancer.
Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673.
Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review.
Pancreatic mucinous cystadenocarcinoma in a patient harbouring BRCA1 germline mutation effectively treated with olaparib: A case report.
PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer.
Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.
PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesis.
Poly (ADP-Ribose) Polymerase 1 Protein Expression in Normal Pancreas and Pancreatic Adenocarcinoma.
Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures.
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.
Rapid Progression of Metastatic Pancreatic Adenocarcinoma During Platinum-Based Therapy in a Patient Harboring a Pathogenic BRCA2 Germline Variant.
Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion.
Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): an open-label, phase 2 trial.
Targeted PARP Inhibition Combined with FGFR1 Blockade is Synthetically Lethal to Malignant Cells in Patients with Pancreatic Cancer.
The BET inhibitor JQ1 attenuates double-strand break repair and sensitizes models of pancreatic ductal adenocarcinoma to PARP inhibitors.
The role of PARP inhibitors in germline BRCA-associated pancreatic ductal adenocarcinoma.
Treatment Options for Germline BRCA-Mutated Metastatic Pancreatic Adenocarcinoma.
Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types.
ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines.
Adenocarcinoma of Lung
ATM deficiency is associated with sensitivity to PARP1 and ATR inhibitors in lung adenocarcinoma.
Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy.
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.
Diagnostic and therapeutic ER?, HER2, BRCA biomakers in the histological subtypes of lung adenocarcinoma according to the IASLC/ATS/ERS classification.
Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells.
Erucin, a new promising cancer chemopreventive agent from rocket salads, shows anti-proliferative activity on human lung carcinoma A549 cells.
Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair.
Poly (ADP-ribose) polymerase-1 Binding Protein Facilitates Lung Adenocarcinoma Cell Proliferation and Correlates with Poor Prognosis.
Reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 and PARP-2 knockout mice.
Response to olaparib in metastatic lung adenocarcinoma with germline BRCA2 mutation: a case report.
Stenoparib, an Inhibitor of Cellular Poly(ADP-Ribose) Polymerase, Blocks Replication of the SARS-CoV-2 and HCoV-NL63 Human Coronaviruses In Vitro.
Targeting MALAT1 induces DNA damage and sensitize non-small cell lung cancer cells to cisplatin by repressing BRCA1.
The Joint Effect of hOGG1, APE1, and ADPRT Polymorphisms and Cooking Oil Fumes on the Risk of Lung Adenocarcinoma in Chinese Non-Smoking Females.
Adenoma
Abnormal dopamine sensitivity in some human prolactinomas.
Effect of prostaglandin F2 alpha on human parathyroid adenomas: evidence for uncoupling of parathyroid hormone secretion and cAMP accumulation.
Effects of cumene hydroperoxide on adenosine diphosphate ribosyl transferase in mononuclear leukocytes of patients with adenomatous polyps in the colon.
Fish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo.
Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma.
Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis.
Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.
PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1.
Pertussis toxin inhibits somatostatin-induced K+ conductance in human pituitary tumor cells.
Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.
Some changes of receptor and postreceptor signal transduction regulated by somatostatin in pituitary hGH-secreting adenomas.
Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ mice.
Adenomatous Polyposis Coli
Absence of stimulation of poly(ADP-ribose) polymerase activity in patients predisposed to colon cancer.
Glial reactions and degeneration of myelinated processes in spinal cord gray matter in chronic experimental autoimmune encephalomyelitis.
Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly.
Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.
Adenoviridae Infections
An enzyme-linked-immunosorbent assay method for detection of immunoglobulins to pertussis toxin.
Adrenal Cortex Neoplasms
Bitter Melon (Momordica charantia) Extract Suppresses Adrenocortical Cancer Cell Proliferation Through Modulation of the Apoptotic Pathway, Steroidogenesis, and Insulin-Like Growth Factor Type 1 Receptor/RAC-? Serine/Threonine-Protein Kinase Signaling.
Adrenal Insufficiency
Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis.
Adrenocortical Carcinoma
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Albuminuria
Tempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus.
Theobromine increases NAD?/Sirt-1 activity and protects the kidney under diabetic conditions.
Alveolar Bone Loss
Role of poly(ADP-ribose) polymerase activation in the pathogenesis of periodontitis in diabetes.
Alzheimer Disease
Activation of PARP by oxidative stress induced by ?-amyloid: implications for Alzheimer's disease.
Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose) polymerase activity in the hippocampus.
Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death.
Bioenergetic Impairment in Animal and Cellular Models of Alzheimer's Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions.
Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimer's Disease.
Correction: Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
Efficacy and safety of NAD+ ADP-ribosyltransferase 1 agonist versus Donepezil in elderly Chinese patients with Alzheimer disease: A novel target for effective therapy.
Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease.
Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment.
In silico identification of AChE and PARP-1 dual-targeted inhibitors of Alzheimer's disease.
Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease.
Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders.
Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk.
Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.
Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target.
Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in A?(1-42)-induced rat model of Alzheimer's disease.
Nucleolar PARP-1 Expression Is Decreased in Alzheimer's Disease: Consequences for Epigenetic Regulation of rDNA and Cognition.
Papers of note in Science Translational Medicine 9 (392).
Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
PARP1 gene variation and microglial activity on [(11)C]PBR28 PET in older adults at risk for Alzheimer's disease.
Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases.
Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications.
Poly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease.
PolyADP-ribosylation is involved in neurotrophic activity.
Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors.
The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study.
The role of poly(ADP-ribose) polymerase-1 in CNS disease.
Transient OGG1, APE1, PARP1 and Pol? expression in an Alzheimer's disease mouse model.
Variants of Base Excision Repair Genes MUTYH , PARP1 and XRCC1 in Alzheimer's Disease Risk.
Amnesia
Differential prevention of morphine amnesia by antisense oligodeoxynucleotides directed against various Gi-protein alpha subunits.
Effect of pertussis toxin on baclofen- and diphenhydramine-induced amnesia.
Inhibition of PARP-1 participates in the mechanisms of propofol-induced amnesia in mice and human.
Amyotrophic Lateral Sclerosis
Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA.
Low levels of selenium compounds are selectively toxic for a human neuron cell line through ROS/RNS increase and apoptotic process activation.
PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients.
Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases.
Reactive astrocytes express PARP in the central nervous system of SOD(G93A) transgenic mice.
Anaphylaxis
Adjuvant effect of pertussis toxin on the production of anti-ovalbumin IgE in mice and lack of direct correlation between PCA and ELISA.
Anaphylaxis and mortality induced by treatment of mice with anti-VLA-4 antibody and pertussis toxin.
Anaphylaxis to a self-peptide in the absence of mast cells or histamine.
Asiasari radix inhibits immunoglobulin E production on experimental models in vitro and in vivo.
Basophil activation through ASGM1 stimulation triggers PAF release and anaphylaxis-like shock in mice.
Disodium cromoglycate inhibits production of immunoglobulin E.
Inhibition of immunoglobulin E production by Poncirus trifoliata fruit extract.
Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens.
Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction.
Pertussis toxin enhanced IgG1 and IgE responses to primary tetanus immunization are mediated by interleukin-4 and persist during secondary responses to tetanus alone.
Suppression of passive cutaneous anaphylaxis by pertussis toxin, an islet-activating protein, as a result of inhibition of histamine release from mast cells.
Anemia
Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials.
Erythropoietin-driven signalling and cell migration mediated by polyADP-ribosylation.
Haematologic toxicities with PARP inhibitors in cancer patients: an up-to-date meta-analysis of 29 randomized controlled trials.
PARP inhibitors in ovarian cancer: Clinical evidence for informed treatment decisions.
PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.
Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials.
Therapeutic options following second-line platinum-based chemotherapy in patients with recurrent ovarian cancer: Comparison of active surveillance and maintenance treatment.
[Analysis of PARP inhibitors induced anemia in advanced and relapsed epithelial ovarian cancer].
[Interstitial Pneumonia Caused by Olaparib during Treatment of Breast Cancer-A Case Report].
Aneurysm
Clinical perspectives of PARP inhibitors.
Pharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: future directions.
Angina, Unstable
Activation and overexpression of PARP-1 in circulating mononuclear cells promote TNF-alpha and IL-6 expression in patients with unstable angina.
Angioedema
Angioedema as a predominant symptom of Bordetella pertussis infection.
Angiomyolipoma
Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress.
Anthrax
cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin.
Caspase- and p53-dependent apoptosis in breast carcinoma cells induced by a synthetic selenadiazole derivative.
Monoclonal antibodies and toxins--a perspective on function and isotype.
Antiphospholipid Syndrome
Poly(ADP-ribose) polymerase alleles in French Caucasians are associated neither with lupus nor with primary antiphospholipid syndrome. GRAID Research Group. Group for Research on Auto-Immune Disorders.
Aortic Aneurysm, Abdominal
PARP-1 (Poly[ADP-Ribose] Polymerase 1) Inhibition Protects From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm in Mice.
Aortic Valve Stenosis
Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity.
Apnea
Effect of pertussis toxin treatment on the putative adenosine A3 receptor-mediated hypotensive response in the rat.
The role of A3 adenosine receptors in central regulation of arterial blood pressure.
Arrhythmias, Cardiac
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.
Arthritis
Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis.
GPI 6150, a poly (ADP-ribose) polymerase inhibitor, exhibits an anti-inflammatory effect in rat models of inflammation.
Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy.
Modulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase.
Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases.
Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice.
Poly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus.
Poly(ADP-ribose) polymerase inhibitors.
Poly(ADP-ribose) polymerase-1 inhibitor modulates T regulatory and IL-17 cells in the prevention of adjuvant induced arthritis in mice model.
Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity.
Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase.
Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies.
Therapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response.
Arthritis, Experimental
Synergistic effects of thalidomide and poly (ADP-ribose) polymerase inhibition on type II collagen-induced arthritis in mice.
Therapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response.
Arthritis, Rheumatoid
A poly(ADP-ribose) polymerase haplotype spanning the promoter region confers susceptibility to rheumatoid arthritis.
Beyond dna repair,the immunological role of parp-1 and its siblings.
Lack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population.
PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases.
Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice.
Poly(ADP-ribose) polymerase inhibition reduces tumor necrosis factor-induced inflammatory response in rheumatoid synovial fibroblasts.
Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease.
The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1.
The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis.
The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients.
Therapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response.
Asbestosis
Poly(ADP-ribosyl)ation in asthma and other lung diseases.
Asthma
Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach.
Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis.
Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma.
Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma.
Genomic Instability in Chronic Airway Inflammatory Diseases.
Increased poly(ADP-ribose) polymerase (PARP)-1 expression and activity are associated with inflammation but not goblet cell metaplasia in murine models of allergen-induced airway inflammation.
Inhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs.
Investigation of poly (ADP-ribose) polymerase-1 genetic variants as a possible risk for allergic rhinitis.
Minocycline blocks asthma-associated inflammation in part by interfering with the T cell receptor-nuclear factor ?B-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase.
Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases.
PARP inhibition by olaparib alleviates chronic asthma-associated remodeling features via modulating inflammasome signaling in mice.
PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.
PARP inhibition treatment in a nonconventional experimental mouse model of chronic asthma.
PARP inhibitor, olaparib ameliorates acute lung and kidney injury upon intratracheal administration of LPS in mice.
PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice.
PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model.
PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice.
PARP-1 Is Critical for Recruitment of Dendritic Cells to the Lung in a Mouse Model of Asthma but Dispensable for Their Differentiation and Function.
PARP-1: a new player in the asthma field?
Poly(ADP-Ribose)Polymerase-1 in Lung Inflammatory Disorders: A Review.
Poly(ADP-ribosyl)ation in asthma and other lung diseases.
Silencing of poly(ADP-ribose) polymerase-1 suppresses hyperstretch-induced expression of inflammatory cytokines in vitro.
The Ala allele at Val762Ala polymorphism in poly(ADP-ribose) polymerase-1 (PARP-1) gene is associated with a decreased risk of asthma in a Turkish population.
The pertussis hypothesis: Bordetella pertussis colonization in the etiology of asthma and diseases of allergic sensitization.
The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis.
[Involvement of G proteins between receptors and KCa channels in the regulation of airway tone by the autonomic nervous system]
Astrocytoma
Comparative status of activated ERK1/2 and PARP cleavage in human gliomas.
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.
Inhibition of Mer and Axl Receptor Tyrosine Kinases in Astrocytoma Cells Leads to Increased Apoptosis and Improved Chemosensitivity.
PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma.
PARP1 expression in pediatric central nervous system tumors.
Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization.
The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain.
Tumor treating fields combined with a poly (adenosine diphosphate-ribose) polymerase inhibitor during radiotherapy for rapidly progressing IDH-wildtype diffuse astrocytoma: a case report.
[Functional characteristics of nucleotide-receptors in human neutrophils]
Asymptomatic Infections
Cell-mediated immune responses to antigens of Bordetella pertussis and protection against pertussis in school children.
Widespread silent transmission of pertussis in families: antibody correlates of infection and symptomatology.
Ataxia
Acute ethanol-induced adenosine diphosphate ribosylation regulates the functional activity of rat striatal pertussis toxin-sensitive g proteins.
Cerebellar CB(1) receptor mediation of Delta(9)-THC-induced motor incoordination and its potentiation by ethanol and modulation by the cerebellar adenosinergic A(1) receptor in the mouse.
Interactions of intracerebroventricular pertussis toxin treatment with the ataxic and hypothermic effects of ethanol.
Involvement of kappa-opioids in the mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination.
Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptor.
Mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination: possible involvement of cAMP.
p53 Activation by nitric oxide involves down-regulation of Mdm2.
The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest.
The promise of DNA damage response inhibitors for the treatment of glioblastoma.
XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.
Ataxia Telangiectasia
53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability.
Analyzing the Opportunities to Target DNA Double-Strand Breaks Repair and Replicative Stress Responses to Improve Therapeutic Index of Colorectal Cancer.
ATM-Deficient Cancers Provide New Opportunities for Precision Oncology.
ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms.
Biomarker-Guided Development of DNA Repair Inhibitors.
Ceralasertib-Mediated ATR Inhibition Combined With Olaparib in Advanced Cancers Harboring DNA Damage Response and Repair Alterations (Olaparib Combinations).
Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints.
Down-expression of poly(ADP-ribose) polymerase in p53-regulated pancreatic cancer cells.
Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53.
Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
Histone deacetylase 2 is involved in DNA damage-mediated cell death of human osteosarcoma cells through stimulation of the ATM/p53 pathway.
Identification of proteins in the hamster DNA end-binding complex.
Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy.
Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.
Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells.
Introductory review: involvement of ADP-ribosylation in cellular recovery from some forms of DNA damage.
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells.
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.
Mitochondrial protein ATPase family, AAA domain containing 3A correlates with radioresistance in glioblastoma.
Monitoring and signaling of radiation-induced damage in mammalian cells.
Novel and emerging drugs for rarer chronic lymphoid leukaemias.
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
PARP10 deficiency manifests by severe developmental delay and DNA repair defect.
Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma.
Poly(ADP-ribose) polymerase activity is not affected in ataxia telangiectasia cells and knockout mice.
Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer.
Replication Stress: An Achilles' Heel of Glioma Cancer Stem-like Cells.
Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.
S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells.
Shelterin-Mediated Telomere Protection.
Targeted cancer therapies based on the inhibition of DNA strand break repair.
Targeting DNA Damage Repair for Immune Checkpoint Inhibition: Mechanisms and Potential Clinical Applications.
Targeting poly(ADP-ribose) polymerase and the c-Myb-regulated DNA damage response pathway in castration-resistant prostate cancer.
The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
The Herpesvirus Nuclear Egress Complex Component, UL31, Can Be Recruited to Sites of DNA Damage Through Poly-ADP Ribose Binding.
The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells.
The promise of DNA damage response inhibitors for the treatment of glioblastoma.
Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer.
Atherosclerosis
Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging.
Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1.
Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation.
Low shear stress induced HMGB1 translocation and release via PECAM-1/PARP-1 pathway to induce inflammation response.
Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases.
Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy.
PARP inhibition in atherosclerosis and its effects on dendritic cells, T cells and auto-antibody levels.
PARP-1 Involvement in Autophagy and Their Roles in Apoptosis of Vascular Smooth Muscle Cells under Oxidative Stress.
PARP-1 Represses LXR-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.
PARP1 is required for adhesion molecule expression in atherogenesis.
PARPs in lipid metabolism and related diseases.
Phenotypic Switching of Atherosclerotic Smooth Muscle Cells is Regulated by Activated PARP1-Dependent TET1 Expression.
PJ34, a PARP1 inhibitor, promotes endothelial repair in a rabbit model of high fat diet-induced atherosclerosis.
Poly (ADP-Ribose) Polymerase 1 Mediated Arginase II Activation Is Responsible for Oxidized LDL-Induced Endothelial Dysfunction.
Poly (ADP-Ribose) Polymerase Inhibition Attenuates Atherosclerotic Plaque Development in ApoE-/- Mice with Hyperhomocysteinemia.
Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.
Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications.
Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aortic atherogenesis through downregulation of arginase II.
Poly(ADP-ribose) polymerase 1 inhibition protects against low shear stress induced inflammation.
Poly(ADP-ribose) polymerase 1 inhibition protects human aortic endothelial cells against LPS-induced inflammation response.
Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro.
Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death.
Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure.
Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors.
The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis.
Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content.
Atrial Fibrillation
DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation.
[The epidemiological characteristics and adherence to hypoglycemic agents of ischemic stroke patients with diabetes].
Autoimmune Diseases
Analysis of experimental autoimmune encephalomyelitis induced in F344 rats by pertussis toxin administration.
Apoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin.
Autoantibodies to Poly(ADP-Ribose) Polymerase in Centenarians: A Reappraisal of Grabar's Hypothesis.
Dissociating the enhancing and inhibitory effects of pertussis toxin on autoimmune disease.
Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints.
Histamine H2 receptor signaling x environment interactions determine susceptibility to experimental allergic encephalomyelitis.
Immunomodulation of murine experimental autoimmune encephalomyelitis by pertussis toxin: the protective activity, but not the disease-enhancing activity, can be attributed to the nontoxic B-oligomer.
Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6.
Lymphocyte proliferation induced by pertussis toxin utilizes a pathway parallel to transforming growth factor-beta-sensitive growth.
Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice.
PARP activity and NAD concentration in PMC from patients affected by systemic sclerosis and lupus erythematosus.
Pertussis toxin alters the innate and the adaptive immune responses in a pertussis-dependent model of autoimmunity.
Pertussis toxin enhances Th1 responses by stimulation of dendritic cells.
Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals.
Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28.
Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells.
Pertussis toxin-induced hyperacute autoimmune encephalomyelitis in Lewis rats is correlated with increased expression of inducible nitric oxide synthase and tumor necrosis factor alpha.
Pertussis toxin-induced lymphocytosis is associated with alterations in thymocyte subpopulations.
Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease.
Poly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator.
Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease.
Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells.
Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis.
Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease.
Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications.
The Role of PARP-1 in Host-Pathogen Interaction and Cellular Stress Responses.
Transcriptional reprogramming and resistance to colonic mucosal injury in Poly(ADP-ribose) polymerase 1 (PARP1)-deficient mice.
Azoospermia
An ADP-ribosyltransferase 3 (ART3) variant is associated with reduced sperm counts in Czech males: case/control association study replicating results from the Japanese population.
Association of polymorphisms in ART3 gene with male infertility in the Chinese population.
Bacterial Infections
Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections.
Monocyte Trafficking to Hepatic Sites of Bacterial Infection Is Chemokine Independent and Directed by Focal Intercellular Adhesion Molecule-1 Expression.
Barrett Esophagus
Dysregulation of PARP1 is involved in development of Barrett's esophagus.
MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1.
Bicuspid Aortic Valve Disease
Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity.
Biliary Tract Neoplasms
Biliary tract cancer and genomic alterations in homologous recombinant deficiency: exploiting synthetic lethality with PARP inhibitors.
Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer.
Investigational PARP inhibitors for the treatment of biliary tract cancer: spotlight on preclinical and clinical studies.
PARP Inhibitors in Biliary Tract Cancer: A New Kid on the Block?
Blister
Activation of poly [ADP-Ribose] polymerase in endothelial cells and keratinocytes: role in an in vitro model of sulfur mustard-mediated vesication.
Cell surface antigens of Bordetella pertussis.
Involvement of small GTPases Rho and Rac in the invasion of rat ascites hepatoma cells.
Neolignans from Nectandra megapotamica (Lauraceae) Display in vitro Cytotoxic Activity and Induce Apoptosis in Leukemia Cells.
PARP determines the mode of cell death in skin fibroblasts, but not keratinocytes, exposed to sulfur mustard.
Putative role of proteolysis and inflammatory response in the toxicity of nerve and blister chemical warfare agents: implications for multi-threat medical countermeasures.
The SC-35 Splicing Factor Interacts with RNA Pol II and A-Type Lamin Depletion Weakens This Interaction.
Two phases of pseudopod protrusion in tumor cells revealed by a micropipette.
Bloom Syndrome
Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors.
Identification of proteins in the hamster DNA end-binding complex.
Bone Diseases
NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity.
Bone Neoplasms
Spinal RhoA/Rho Kinase Signaling Pathway may Participate in the Development of Bone Cancer Pain.
Bone Resorption
Effects of pertussis toxin on resorption of 19-day-old fetal rat long bones.
Inhibitory action of pertussis toxin on parathyroid hormone and prostaglandin E2-stimulated bone resorption in cultured neonatal mouse calvaria.
Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones.
Rho-A is critical for osteoclast podosome organization, motility, and bone resorption.
Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis.
Stimulation of a Gs-like G protein in the osteoclast inhibits bone resorption but enhances tartrate-resistant acid phosphatase secretion.
The small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts.
Bordetella Infections
Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen.
Polymorphism in the pertussis toxin promoter region affecting the DNA-based diagnosis of Bordetella infection.
Western blot analysis of antibody responses of young infants to pertussis infection.
Bradycardia
Altered sinus nodal and atrioventricular nodal function in freely moving mice overexpressing the A1 adenosine receptor.
Differentiation of muscarinic receptors mediating negative chronotropic and vasoconstrictor responses to acetylcholine in isolated rat hearts.
Effect of pertussis toxin treatment on the putative adenosine A3 receptor-mediated hypotensive response in the rat.
Enhanced negative chronotropy by inhibitory receptors in transgenic heart overexpressing beta(2)-adrenoceptors.
Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat.
Preconditioning against infarction in the rat heart does not involve a pertussis toxin sensitive G protein.
Brain Death
Activation and modulation of cardiac poly-adenosine diphosphate ribose polymerase activity in a rat model of brain death.
Brain Diseases
Apoptosis and microglial activation in influenza encephalopathy.
Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor.
Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system.
Murine model for pertussis vaccine encephalopathy: role of the major histocompatibility complex; antibody to albumin and to Bordetella pertussis and pertussis toxin.
PARP inhibition delays progression of mitochondrial encephalopathy in mice.
Pertussis encephalopathy with high cerebrospinal fluid antibody titers to pertussis toxin and filamentous hemagglutinin.
Pertussis toxin is required for pertussis vaccine encephalopathy.
Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice.
Poly(ADP-ribosyl)ation enhancement in brain cell nuclei is associated with diabetic neuropathy.
Brain Edema
Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats.
Poly(ADP-ribose) polymerase activation and brain edema formation by hemoglobin after intracerebral hemorrhage in rats.
Poly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia: its role in brain edema and cell death.
Brain Infarction
Neuronal death in brain infarcts in man.
Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage.
Brain Injuries
A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia.
A novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury: An immunohistochemical and behavioral study.
Acute Meningitis.
At the scene of ischemic brain injury: is PARP a perp?
Biphasic changes in the levels of poly(ADP-ribose) polymerase-1 and caspase 3 in the immature brain following hypoxia-ischemia.
Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats.
Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.
Drug-induced hypothermia begun 5 minutes after injury with a poly(adenosine 5'-diphosphate-ribose) polymerase inhibitor reduces hypoxic brain injury in rat pups.
Effect of 3-Aminobenzamide on the Ultrastructure of Astrocytes and Microvessels After Focal Cerebral Ischemia in Rats.
Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury.
Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains.
Enhanced poly(ADP-ribose) polymerase-1 activation contributes to recombinant tissue plasminogen activator-induced aggravation of ischemic brain injury in vivo.
Hyperglycemia potentiates a shift from apoptosis to RIP1-dependent necroptosis.
Influence of PARP-1 polymorphisms in patients after traumatic brain injury.
Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide.
Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury.
Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.
Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice.
Microglial activation induced by the alarmin S100B is regulated by poly(ADP-ribose) polymerase-1.
NAD+ and NADH in ischemic brain injury.
NAD+ Metabolism and NAD+-Dependent Enzymes: Promising Therapeutic Targets for Neurological Diseases.
Neuroprotective effects of a novel Poly (ADP-Ribose) Polymerase-1 inhibitor, JPI-289, in hypoxic rat cortical neurons.
Neuroprotective effects of KCL-440, a new poly(ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model.
Nicotinamide mononucleotide administration after sever hypoglycemia improves neuronal survival and cognitive function in rats.
Oxidative Stress and NAD(+) in Ischemic Brain Injury: Current Advances and Future Perspectives.
Oxidative stress in bacterial meningitis.
PARP inhibition attenuates early brain injury through NF-?B/MMP-9 pathway in a rat model of subarachnoid hemorrhage.
PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury.
Poly(ADP-ribose) polymerase is not involved in the neuroprotection exerted by azithromycin against ischemic stroke in mice.
Poly(ADP-ribose) polymerase-1 and its clinical applications in brain injury.
Poly(ADP-ribosyl)ation and stroke.
Postnatal Age Influences Hypoglycemia-induced Poly(ADP-ribose) Polymerase-1 Activation in the Brain Regions of Rats.
Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke.
Roles of NAD (+) , PARP-1, and Sirtuins in Cell Death, Ischemic Brain Injury, and Synchrotron Radiation X-Ray-Induced Tissue Injury.
Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke.
Temporal patterns of poly(ADP-ribose) polymerase activation in the cortex following experimental brain injury in the rat.
[Involvement of caspase on apoptosis in ischemia-induced neuronal cell death: usefulness of caspase inhibitors for stroke therapy]
Brain Injuries, Traumatic
A dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3gamma.
Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1.
Alternative mechanisms of inhibiting activity of poly (ADP-ribose) polymerase-1.
Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat.
Effect of 3-Aminobenzamide on the Ultrastructure of Astrocytes and Microvessels After Focal Cerebral Ischemia in Rats.
Effect of Acute Poly(ADP-Ribose) Polymerase Inhibition by 3-AB on Blood-Brain Barrier Permeability and Edema Formation After Focal Traumatic Brain Injury in Rats.
Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury.
Increased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection.
Influence of PARP-1 polymorphisms in patients after traumatic brain injury.
Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide.
Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy.
Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice.
Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor.
PARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma.
PARP-1 Inhibition Attenuates Neuronal Loss, Microglia Activation and Neurological Deficits after Traumatic Brain Injury.
PARP1 might enhance the therapeutic effect of tetrahydroxystilbene glucoside in traumatic brain injury via inhibition of Ras/JNK signalling pathway.
Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats.
Poly(ADP ribose) polymerase cleavage precedes neuronal death in the hippocampus and cerebellum following injury to the developing rat forebrain.
Poly(ADP-Ribose)Polymerase 1 (PARP-1) Activation and Ca(2+) Permeable ?-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Channels in Post-Ischemic Brain Damage: New Therapeutic Opportunities?
Protective actions of PJ34, a poly(ADP-ribose)polymerase inhibitor, on the blood-brain barrier after traumatic brain injury in mice.
Protective effects of PARP inhibitor, PJ34, is related to down-regulation of calpain and NF-?B in a mouse model of TBI.
Protective functions of PJ34, a PARP inhibitor, is related to down-regulation of calpain and NF-?B in a mouse model of TBI.
Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase.
The expression pattern of ADP-ribosyltransferase 3 in rat traumatic brain injury.
Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report.
[Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase]
Brain Ischemia
3-Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice.
A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats.
A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia.
Another "string to the bow" of PJ34, a potent poly(ADP-Ribose)polymerase inhibitor: an antiplatelet effect through P2Y12 antagonism?
Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice.
Apoptosis-inducing factor triggered by poly(ADP-Ribose) polymerase and bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.
Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis.
Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair.
Combined therapy with PJ34, a poly(ADP-ribose)polymerase inhibitor, reduces tissue plasminogen activator-induced hemorrhagic transformations in cerebral ischemia in mice.
Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors.
Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia.
Different doses of dexmedetomidine reduce plasma cytokine production, brain oxidative injury, PARP and caspase expression levels but increase liver oxidative toxicity in cerebral ischemia-induced rats.
Differential PARP Cleavage: An Indication of Heterogeneous Forms of Cell Death and Involvement of Multiple Proteases in the Infarct of Focal Cerebral Ischemia in Rat.
Effect of 3-aminobenzamide, PARP inhibitor, on matrix metalloproteinase-9 level in plasma and brain of ischemic stroke model.
Enhanced poly(ADP-ribose) polymerase-1 activation contributes to recombinant tissue plasminogen activator-induced aggravation of ischemic brain injury in vivo.
Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain.
Epigallocatechin gallate alleviates neuronal cell damage against focal cerebral ischemia in rats.
Ginsenoside Rd blocks AIF mitochondrio-nuclear translocation and NF-?B nuclear accumulation by inhibiting poly(ADP-ribose) polymerase-1 after focal cerebral ischemia in rats.
Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice.
Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia.
Inhibition of poly(ADP-ribose) polymerase: reduction of ischemic injury and attenuation of N-methyl-D-aspartate-induced neurotransmitter dysregulation.
Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury.
Ischemia of rat brain decreases pertussis toxin-catalyzed [32P]ADP ribosylation of GTP-binding proteins (Gi1 and G0) in membranes.
Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection.
Mitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation.
Natural Inhibitors of Poly(ADP-ribose) Polymerase-1.
Neuropilin-1 modulates vascular endothelial growth factor-induced poly(ADP-ribose)-polymerase leading to reduced cerebrovascular apoptosis.
Neuroprotection by the PARP inhibitor PJ34 modulates cerebral and circulating RAGE levels in rats exposed to focal brain ischemia.
Neuroprotective effects of a novel water-soluble poly(ADP-ribose) polymerase-1 inhibitor, MP-124, in in vitro and in vivo models of cerebral ischemia.
Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation.
Neuroprotective effects of poly (ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats.
Neuroprotective Properties of Picroside II in a Rat Model of Focal Cerebral Ischemia.
NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase.
Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.
Oxidative Stress and NAD(+) in Ischemic Brain Injury: Current Advances and Future Perspectives.
Oxidative stress in brain ischemia.
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration.
Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation.
Pertussis Toxin Ameliorates Microglial Activation Associated With Ischemic Stroke.
Poly (ADP-ribose) polymerase-1 initiated neuronal cell death pathway--do androgens matter?
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.
Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke.
Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells.
Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia.
Poly(ADP-Ribose)-Polymerase-Catalyzed Hydrolysis of NAD(+): QM/MM Simulation of the Enzyme Reaction.
Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage.
Poly(ADP-ribosyl)ation and stroke.
Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia.
Protection of the brain following cerebral ischemia through the attenuation of PARP-1-induced neurovascular unit damage in rats.
Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke.
Reduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in mice.
Role of continuous high thoracic epidural anesthesia in hippocampal apoptosis after global cerebral ischemia in rats.
Role of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia.
Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke.
SPATIAL AND FUNCTIONAL RELATIONSHIP BETWEEN POLY(ADP-RIBOSE) POLYMERASE-1 AND POLY(ADP-RIBOSE) GLYCOHYDROLASE IN THE BRAIN.
The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase.
The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia.
Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors.
[Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase]
Brain Neoplasms
A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity.
A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a Pediatric Brain Tumor Consortium report†
Association Between PARP1 Single Nucleotide Polymorphism and Brain Tumors.
Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors.
Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumors.
Chemopotentiation by PARP inhibitors in cancer therapy.
DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.
Niraparib as Maintenance Therapy in Germline ATM-mutated and Somatic BRCA2-mutated Ovarian Cancer with Brain Metastases: A Case Report and Literature Review.
Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models.
Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice.
Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumor.
PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.
Preclinical and first-in-human-brain-cancer applications of [18F]poly (ADP-ribose) polymerase inhibitor PET/MR.
Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma.
Successful treatment of a patient with brain metastases from endometrial cancer using Niraparib: a case report.
Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis.
Targeted Therapies for Breast Cancer Brain Metastases.
Targeted Therapy for Brain Tumours: Role of PARP Inhibitors.
The potential role and application of PARP inhibitors in cancer treatment.
Transferrin Modified GSH Sensitive Hyaluronic Acid Derivative Micelle to Deliver HSP90 Inhibitors to Enhance the Therapeutic Efficacy of Brain Cancers.
Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome.
Whole-body hyperthermia and ADPRT inhibition in experimental treatment of brain tumors.
Breast Diseases
Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis.
Breast Neoplasms
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress, DNA strand breaks, and poly(ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines.
2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the induction of DNA strand breaks and poly(ADP-ribose) polymerase-1 activation by 17beta-estradiol in human breast carcinoma cells through alteration of CYP1A1 and CYP1B1 expression.
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
3-Aminobenzamide delays rejoining of DNA strand breaks in gamma-irradiated lymphocytes from patients with breast cancer and not cervical cancer.
4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells.
4-Hydroxybenzoic acid (4-HBA) enhances the sensitivity of human breast cancer cells to adriamycin as a specific HDAC6 inhibitor by promoting HIPK2/p53 pathway.
4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.
53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
?-hydroxyundec-9-enoic acid induces apoptosis by ROS mediated JNK and p38 phosphorylation in breast cancer cell lines.
?-hydroxyundec-9-enoic acid induction of breast cancer cells apoptosis through generation of mitochondrial ROS and phosphorylation of AMPK.
?-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXR?-AKT Signaling Pathway.
A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity.
A Comparative Study of the Anticancer Activity and PARP-1 Inhibiting Effect of Benzofuran-Pyrazole Scaffold and Its Nano-Sized Particles in Human Breast Cancer Cells.
A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging.
A DNA Repair BRCA1 Estrogen Receptor and Targeted Therapy in Breast Cancer.
A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity.
A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer.
A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice.
A novel crosstalk between BRCA1 and poly (ADP-ribose) polymerase 1 in breast cancer.
A Phase 1 trial of the poly(ADP-ribose) polymerase inhibitor olaparib (AZD2281) in combination with the anti-angiogenic cediranib (AZD2171) in recurrent epithelial ovarian or triple-negative breast cancer.
A phase I dose-finding, pharmacokinetics and genotyping study of olaparib and lurbinectedin in patients with advanced solid tumors.
A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protocol for a randomized controlled trial.
A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type Tumors.
A Population Pharmacokinetic Meta-Analysis of Veliparib, a PARP Inhibitor, Across Phase 1/2/3 Trials in Cancer Patients.
A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma.
A randomized Phase II study of veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in BRCA1/2 metastatic breast cancer: design and rationale.
A real or apparent decrease in glomerular filtration rate in patients using olaparib?
A review of current progress in triple-negative breast cancer therapy.
A review of triple-negative breast cancer.
A Review on Poly (ADP-ribose) Polymerase (PARP) Inhibitors and Synthetic Methodologies.
A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors.
A systematic review of international guidelines and recommendations for the genetic screening, diagnosis, genetic counseling, and treatment of BRCA-mutated breast cancer.
ABC4 Consensus: First Latin American Meeting-Assessment, Comments, and Application of Its Recommendations.
ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461.
ABT-888 and quinacrine induced apoptosis in metastatic breast cancer stem cells by inhibiting base excision repair via adenomatous polyposis coli.
Actionable co-alterations in breast tumors with pathogenic mutations in the homologous recombination DNA damage repair pathway.
Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells.
Activation of choline kinase by extracellular Ca2+ is Ca(2+)-sensing receptor, Galpha12 and Rho-dependent in breast cancer cells.
Activation of HIF-1? by ?-Opioid Receptors Induces COX-2 Expression in Breast Cancer Cells and Leads to Paracrine Activation of Vascular Endothelial Cells.
Adenovirus-mediated p53 and ING4 gene co?transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer.
Adjuvant PARP Inhibitors in Patients With High-Risk Early-Stage HER2-Negative Breast Cancer and Germline BRCA Mutations: ASCO Hereditary Breast Cancer Guideline Rapid Recommendation Update.
Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells.
ADP ribose polymerase inhibitors for treating non-small cell lung cancer: new additions to the pharmacotherapeutic armamentarium.
Advances in PARP inhibitors for the treatment of breast cancer.
Advances in the use of PARP inhibitor therapy for breast cancer.
Advances in the use of PARP inhibitors for BRCA1/2-associated breast cancer: talazoparib.
Airborne particulate collected from central Taiwan induces DNA strand breaks, Poly(ADP-ribose) polymerase-1 activation, and estrogen-disrupting activity in human breast carcinoma cell lines.
Amplification of the Mutation-Carrying BRCA2 Allele Promotes RAD51 Loading and PARP Inhibitor Resistance in the Absence of Reversion Mutations.
An HTS-compatible HTRF assay measuring the glycohydrolase activity of human PARG.
An Overview of PARP Inhibitors for the Treatment of Breast Cancer.
An update on PARP inhibitors--moving to the adjuvant setting.
Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients.
Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma.
Androgen receptor inhibitor enhances the anti-tumor effect of PARP inhibitor in breast cancer cells by modulating DNA damage response.
Anti-miR-203 Upregulates SOCS3 Expression in Breast Cancer Cells and Enhances Cisplatin Chemosensitivity.
Anticancer activities of an anthocyanin-rich extract from black rice against breast cancer cells in vitro and in vivo.
Anticancer activity of RAPTA-EA1 in triple-negative BRCA1 proficient breast cancer cells: single and combined treatment with the PARP inhibitor olaparib.
Antiproliferative and Proapoptotic Activities of Marine Sponge Hyrtios erectus Extract on Breast Carcinoma Cell Line (MCF-7).
Antitumor and anticancer stem cell activity of a poly ADP-ribose polymerase inhibitor olaparib in breast cancer cells.
Apigenin Inhibits Growth of Breast Cancer Cells: The Role of ER? and HER2/neu.
Application and reflection of genomic scar assays in evaluating the efficacy of platinum salts and PARP inhibitors in cancer therapy.
ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways.
Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging.
Association between PARP-1 V762A polymorphism and breast cancer susceptibility in Saudi population.
Association of PARP1 rs4653734, rs907187 and rs1136410 variants with breast cancer risk among Iranian women.
ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition.
Augmentation of the antitumor effects of PARP inhibitors in triple-negative breast cancer via degradation by hydrophobic tagging modulation.
Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation.
Autoimmune response to PARP and BRCA1/BRCA2 in cancer.
Basal activity of a PARP1-NuA4 complex varies dramatically across cancer cell lines.
BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death.
Biological and clinical significance of PARP1 protein expression in breast cancer.
BiPar Sciences presents interim phase 2 results for PARP inhibitor BSI-201 at San Antonio Breast Cancer Symposium.
Bisphosphonates induce apoptosis in human breast cancer cell lines.
Bitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apoptosis.
Blockade of MUC1 expression by glycerol guaiacolate inhibits proliferation of human breast cancer cells.
Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer.
Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.
Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor.
BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile.
Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment.
BRCA mutation testing in determining breast cancer therapy.
BRCA1 and PARP1 mRNA expression during progression from normal breast to ductal carcinoma in situ and invasive breast cancer: a laser microdissection study.
BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer.
BRCA1 promoter methylation in breast cancer patients is associated with response to olaparib/eribulin combination therapy.
BRCA1-methylated sporadic breast cancers are BRCA-like in showing a basal phenotype and absence of ER expression.
BRCA1/2 testing: therapeutic implications for breast cancer management.
BRCA2-Deficient CAPAN-1 Cells are Extremely Sensitive to the Inhibition of Poly (ADP-Ribose) Polymerase: An Issue of Potency.
BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance.
BRCAness: a deeper insight into basal-like breast tumors.
Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumors.
Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) Restrict Oral Availability and Brain Accumulation of the PARP Inhibitor Rucaparib (AG-014699).
Breast cancer under age 40: a different approach.
Breast cancer.
BreastDefend enhances effect of tamoxifen in estrogen receptor-positive human breast cancer in vitro and in vivo.
BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo.
Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway.
Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion.
Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway.
Caspase- and p53-dependent apoptosis in breast carcinoma cells induced by a synthetic selenadiazole derivative.
Catalase Abrogates ?-Lapachone-Induced PARP1 Hyperactivation-Directed Programmed Necrosis in NQO1-Positive Breast Cancers.
Cationic liposome codelivering PI3K pathway regulator improves the response of BRCA1-deficient breast cancer cells to PARP1 inhibition.
Caught in the act: binding of Ku and PARP to MARs reveals novel aspects of their functional interaction.
CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells.
Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients.
Cell-cycle progression and response of germ cell tumors to cisplatin in vitro.
Chemical characterization and biological activity data for a novel indirubin derivative, LDD-1819.
Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk.
Clinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways.
Clinical practice guidelines for BRCA1 and BRCA2 genetic testing.
Clinical trial data and emerging immunotherapeutic strategies: hormone receptor-positive, HER2- negative breast cancer.
Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy.
Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition.
Co-treatment with BEZ235 Enhances Sensitivity of BRCA1-negative Breast Cancer Cells to Olaparib.
Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer.
Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes.
Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for a mouse model of BRCA1-related breast cancer.
Combining poly(ADP-ribose) polymerase inhibitors and immune checkpoint inhibitors in breast cancer: rationale and preliminary clinical results.
Comparative antiproliferative effects of iniparib and olaparib on a panel of triple-negative and non-triple-negative breast cancer cell lines.
Comparative efficacy, safety, and acceptability of single-agent poly (ADP-ribose) polymerase (PARP) inhibitors in BRCA-mutated HER2-negative metastatic or advanced breast cancer: a network meta-analysis.
Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice.
Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP.
Cordyceps militaris Induces Immunogenic Cell Death and Enhances Antitumor Immunogenic Response in Breast Cancer.
Correction to: Molecular targeted drugs resistance impairs double?strand break repair and sensitizes ER?positive breast cancer to PARP inhibitors.
Correction: Association between PARP-1 V762A Polymorphism and Breast Cancer Susceptibility in Saudi Population.
Correction: HP1? is a biomarker for breast cancer prognosis and PARP inhibitor therapy.
Correlation between PARP-1 immunoreactivity and cytomorphological features of parthanatos, a specific cellular death in breast cancer cells.
Corrigendum to "Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization" [Nanomedicine 12 (3) (2016), 745-757].
Cost-Effectiveness Analysis of Olaparib Maintenance Treatment for Germline BRCA-Mutated Metastatic Pancreatic Cancer.
CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in BRCA1-mutated breast cancer cells.
Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer.
Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer.
CUDC-907 enhances TRAIL-induced apoptosis through upregulation of DR5 in breast cancer cells.
Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells.
Current and Future Directions for PARP Inhibition.
Current status and future prospects of PARP inhibitor clinical trials in ovarian cancer.
Cyclin A2 regulates homologous recombination DNA repair and sensitivity to DNA damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors in human breast cancer cells.
Cytoplasmic poly(adenosine diphosphate-ribose) polymerase expression is predictive and prognostic in patients with breast cancer treated with neoadjuvant chemotherapy.
d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway.
Dancing with the DNA damage response: next-generation anti-cancer therapeutic strategies.
Data on the effects of anti-cancer drug of resveratrol in breast cancer cells, MDA-MB-231 cells.
Decreased DNA repair gene XRCC1 expression is associated with radiotherapy-induced acute side effects in breast cancer patients.
Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1.
Deep exploration of PARP inhibitors in breast cancer: monotherapy and combination therapy.
Defective repair of oxidative dna damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase.
Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition.
Deoxyrhapontigenin, a Natural Stilbene Derivative Isolated From Rheum undulatum L. Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Human Breast Cancer Cells.
Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors.
Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy.
Detection of heterogeneity of apoptotic fragments of poly (ADP-ribose) polymerase in MDA-MB-468 breast cancer cells: two-dimensional gel analysis.
Detection of PARP-1 activity based on hyperbranched-poly (ADP-ribose) polymers responsive current in artificial nanochannels.
Development and evaluation of poly adenosine 5'-diphosphate-ribose polymerase 1 immobilization-based receptor chromatography.
Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer.
Development of PARP inhibitors in gynecological malignancies.
Development of poly(ADP-ribose) polymerase inhibitors in the treatment of BRCA-mutated breast cancer.
Development of the PARP inhibitor talazoparib for the treatment of advanced BRCA1 and BRCA2 mutated breast cancer.
Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition.
Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid.
Differential Potential of Pharmacological PARP Inhibitors for Inhibiting Cell Proliferation and Inducing Apoptosis in Human Breast Cancer Cells.
Differential regulation of breast cancer bone metastasis by PARP1 and PARP2.
Discovery of 1-substituted benzyl-quinazoline-2,4(1H,3H)-dione derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors.
Discovery of novel functionalized 1,2,4-triazoles as PARP-1 inhibitors in breast cancer: Design, synthesis and antitumor activity evaluation.
Discovery of novel PARP/PI3K dual inhibitors with high efficiency against BRCA-proficient triple negative breast cancer.
Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy.
Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy.
Disparity in the induction of glutathione depletion, ROS formation, poly(ADP-ribose) polymerase-1 activation, and apoptosis by quinonoid derivatives of naphthalene in human cultured cells.
Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer.
DNA damage repair in breast cancer and its therapeutic implications.
DNA Damage Repair Inhibitor for Breast Cancer Treatment.
DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition.
DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.
Doubling down on the PI3K-AKT-mTOR pathway enhances the antitumor efficacy of PARP inhibitor in triple negative breast cancer model beyond BRCA-ness.
Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating chemotherapeutic drugs.
Downregulation of APE1 potentiates breast cancer cells to olaparib by inhibiting PARP-1 expression.
Downregulation of miR-221-3p and upregulation of its target gene PARP1 are prognostic biomarkers for triple negative breast cancer patients and associated with poor prognosis.
Dramatic response to PARP inhibition in a PALB2-mutated breast cancer: moving beyond BRCA.
Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells.
Drug Targeting of Genomic Instability in Multiple Myeloma.
Dual PARP and RAD51 Inhibitory Drug Conjugates Show Synergistic and Selective Effects on Breast Cancer Cells.
Durvalumab with olaparib and paclitaxel for high-risk HER2-negative stage II/III breast cancer: Results from the adaptively randomized I-SPY2 trial.
Effect of adriamycin on BRCA1 and PARP-1 expression in MCF-7 breast cancer cells.
Effect of Food on the Pharmacokinetics of Olaparib after Oral Dosing of the Capsule Formulation in Patients with Advanced Solid Tumors.
Effect of Oncoxin Oral Solution in HER2-Overexpressing Breast Cancer.
Effect of poly(ADP-ribose)polymerase and DNA topoisomerase I inhibitors on the p53/p63-dependent survival of carcinoma cells.
Effects of germline and somatic events in candidate BRCA-like genes on breast-tumor signatures.
Effects of passive smoking on breast cancer risk in pre/post-menopausal women as modified by polymorphisms of PARP1 and ESR1.
Effects of pertussis toxin on adenylate cyclase responses to prostaglandin E2 and calcitonin in human breast cancer cells.
Efficacy and mechanism of the combination of PARP and CDK4/6 inhibitors in the treatment of triple-negative breast cancer.
Efficacy and pharmacodynamics of niraparib in BRCA-mutant and wild-type intracranial triple-negative breast cancer murine models.
Efficacy and safety of PARP inhibitors in patients with BRCA-mutated advanced breast cancer: A meta-analysis and systematic review.
Efficacy of PARP inhibition combined with EZH2 inhibition depends on BRCA mutation status and microenvironment in breast cancer.
Efficacy of the PARP Inhibitor Veliparib with Carboplatin or as a Single Agent in Patients with Germline BRCA1- or BRCA2-Associated Metastatic Breast Cancer.
Elevated expression of erbB3 confers paclitaxel resistance in erbB2-overexpressing breast cancer cells via upregulation of Survivin.
Emerging PARP inhibitors for treating breast cancer.
Emerging therapeutic modalities of PARP inhibitors in breast cancer.
Enhancement of chemotherapeutically-induced apoptosis in vivo by biochemical modulation of poly (ADP-ribose) polymerase.
Enhancing radiosensitivity: targeting the DNA repair pathways.
Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer.
Epidermal Growth Factor Receptor activation promotes ADA3 acetylation through the AKT-p300 pathway.
Epigenetic bivalent marking is permissive to the synergy of HDAC and PARP inhibitors on TXNIP expression in breast cancer cells.
Erratum to "Doubling Down on the PI3K-AKTmTOR Pathway Enhances the Antitumor Efficacy of PARP Inhibitor in Triple Negative Breast Cancer Model beyond BRCA-ness" [Neoplasia 16 (2014) 43-72].
Erratum to: 53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
Erythropoietin-driven signalling and cell migration mediated by polyADP-ribosylation.
Estrogen enhances the cytotoxicity of PARP inhibitors on breast cancer cells through stimulating nitric oxide production.
Evaluation of efficacy and safety of PARP inhibitors in breast cancer: A systematic review and meta-analysis.
Evaluation of the pharmacodynamics and pharmacokinetics of the PARP inhibitor olaparib: a Phase I multicentre trial in patients scheduled for elective breast cancer surgery.
Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis.
Evidence to date: talazoparib in the treatment of breast cancer.
Exploiting DNA repair defects in breast cancer: from chemotherapy to immunotherapy.
Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer.
Expression of DNA Damage Response Molecules PARP1, ?H2AX, BRCA1, and BRCA2 Predicts Poor Survival of Breast Carcinoma Patients.
Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations.
EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer.
Ferulic acid in combination with PARP inhibitor sensitizes breast cancer cells as chemotherapeutic strategy.
First PARP Inhibitor Ok'd for Breast Cancer.
Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity.
Function and mechanism of combined PARP-1 and BRCA genes in regulating the radiosensitivity of breast cancer cells.
Functional Ex Vivo Assay to Select Homologous Recombination-Deficient Breast Tumors for PARP Inhibitor Treatment.
Functional profiling of nucleotide Excision repair in breast cancer.
G-protein-mediated epidermal growth factor signal transduction in a human breast cancer cell line. Evidence for two intracellular pathways distinguishable by pertussis toxin.
Gain-of-Function Mutant p53 R273H Interacts with Replicating DNA and PARP1 in Breast Cancer.
Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family.
Gallic acid and curcumin induce cytotoxicity and apoptosis in human breast cancer cell MDA-MB-231.
GALNT6 Promotes Tumorigenicity and Metastasis of Breast Cancer Cell via ?-catenin/MUC1-C Signaling Pathway.
Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells.
gammaH2AX and cleaved PARP-1 as apoptotic markers in irradiated breast cancer BT474 cellular spheroids.
Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery.
GATA3 cooperates with PARP1 to regulate CCND1 transcription through modulating histone H1 incorporation.
Gene 33 inhibits apoptosis of breast cancer cells and increases poly(ADP-ribose) polymerase expression.
Gene expression and pathologic response to neoadjuvant chemotherapy in breast cancer.
Genetic and epigenetic heterogeneity of epithelial ovarian cancer and the clinical implications for molecular targeted therapy.
Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer.
Genetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer.
Genetic sequence variations and ADPRT haplotype analysis in French Canadian families with high risk of breast cancer.
Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer.
Genomic Correlates of DNA Damage in Breast Cancer Subtypes.
Genomic landscape of metastatic breast cancer identifies preferentially dysregulated pathways and targets.
Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.
Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells.
Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization.
Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality.
HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2-overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance.
Hepatocyte growth factor/scatter factor blocks the mitochondrial pathway of apoptosis signaling in breast cancer cells.
HER2 Overexpression Renders Human Breast Cancers Sensitive to PARP Inhibition Independently of Any Defect in Homologous Recombination DNA Repair.
Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors.
High BRCA2 Gene Expression is Associated with Aggressive and Highly Proliferative Breast Cancer.
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.
Higher cytoplasmic and nuclear poly(ADP-ribose) polymerase expression in familial than in sporadic breast cancer.
Highlights of the Chemotherapy Foundation Symposium XXVII: therapeutic options for breast cancer.
Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells.
Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy.
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer.
HP1? Is a Biomarker for Breast Cancer Prognosis and PARP Inhibitor Therapy.
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.
Identification of a novel truncating mutation in PALB2 gene by a multigene sequencing panel for mutational screening of breast cancer risk-associated and related genes.
Identification of BRCA2 Cis Double Heterozygous Breast Cancer Cases Using Whole Exome Sequencing: Phenotypic Expression and Impact on Personalized Oncology.
Identifying new piperazine-based PARP1 inhibitors using text mining and integrated molecular modeling approaches.
Immuno-related polymorphisms and cervical cancer risk: The IARC multicentric case-control study.
In silico investigation of PARP-1 catalytic domains in holo and apo states for the design of high-affinity PARP-1 inhibitors.
In vitro assessment of the role of DpC in the treatment of head and neck squamous cell carcinoma.
In vitro cytotoxic effect of PARP inhibitor alone and in combination with nab?paclitaxel on triple?negative and luminal A breast cancer cells.
In vivo visualization of PARP inhibitor pharmacodynamics.
Inactivation of the prolyl isomerase Pin1 sensitizes BRCA1-proficient breast cancer to PARP inhibition.
Increased Expression of FosB through Reactive Oxygen Species Accumulation Functions as Pro-Apoptotic Protein in Piperlongumine Treated MCF7 Breast Cancer Cells.
Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer.
Indirect treatment comparison of olaparib and talazoparib in germline BRCA-mutated HER2-negative metastatic breast cancer.
Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047.
Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells.
Induction of ROS formation, poly(ADP-ribose) polymerase-1 activation, and cell death by PCB126 and PCB153 in human T47D and MDA-MB-231 breast cancer cells.
Inhibition of DNA Repair Pathways and Induction of ROS Are Potential Mechanisms of Action of the Small Molecule Inhibitor BOLD-100 in Breast Cancer.
Inhibition of mTOR downregulates expression of DNA repair proteins and is highly efficient against BRCA2-mutated breast cancer in combination to PARP inhibition.
Inhibition of poly(ADP)-ribose polymerase as a therapeutic strategy for breast cancer.
Inhibition of Poly(ADP-Ribose) Polymerase by Nucleic Acid Metabolite 7-Methylguanine.
Inhibition of Rad51 sensitizes breast cancer cells with wild-type PTEN to olaparib.
Inhibition of SYK kinase does not confer a pro-proliferative or pro-invasive phenotype in breast epithelium or breast cancer cells.
Inhibition of TACC3 by a small molecule inhibitor in breast cancer.
Inhibitors targeting CDK4/6, PARP and PI3K in breast cancer: a review.
INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin.
Integrated proteomic, transcriptomic, and biological network analysis of breast carcinoma reveals molecular features of tumorigenesis and clinical relapse.
Integrating PARP inhibitors into the management of breast cancer: where are we?
Integrating poly(ADP-ribose) polymerase (PARP) inhibitors in the treatment of early breast cancer.
Interaction of BARD1 and HP1 is required for BRCA1 retention at sites of DNA damage.
Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells.
Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells.
Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance.
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Is there an epigenetic component underlying the resistance of triple-negative breast cancers to parp inhibitors?
Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1.
Isodeoxyelephantopin, a Sesquiterpene Lactone Induces ROS Generation, Suppresses NF-?B Activation, Modulates LncRNA Expression and Exhibit Activities Against Breast Cancer.
JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks.
KIFC1 is a novel potential therapeutic target for breast cancer.
Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism.
Knowledge and attitude of hereditary breast cancer among Japanese university female students.
Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers.
Let-7 Status Is Crucial for PARP1 Expression in HER2-Overexpressing Breast Tumors.
Limitations of Systemic Oncological Therapy in Breast Cancer Patients with Chronic Kidney Disease.
Long non-coding RNA H19 regulates proliferation and doxorubicin resistance in MCF-7 cells by targeting PARP1.
Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts.
Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors.
Low E2F2 activity is associated with high genomic instability and PARPi resistance.
LSD1 Overexpression Is Associated with Poor Prognosis in Basal-Like Breast Cancer, and Sensitivity to PARP Inhibition.
Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis.
MAPK4 silencing together with a PARP1 inhibitor as a combination therapy in triple?negative breast cancer cells.
Mechanisms of PARP inhibitor sensitivity and resistance.
Medical Management of newly diagnosed breast cancer in a BRCA1/2 mutation carrier.
Metabolic Stability Assessment of New PARP Inhibitor Talazoparib Using Validated LC-MS/MS Methodology: In silico Metabolic Vulnerability and Toxicity Studies.
Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer.
Metal-Based Inhibition of Poly(ADP-ribose) Polymerase - The Guardian Angel of DNA.
Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro.
Methoxyphenylcipro induces antitumor activity in human cancer cells.
Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad.
MGMT Inhibition Restores ER? Functional Sensitivity to Anti-Estrogen Therapy.
MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers.
miR-151-5p, targeting chromatin remodeler SMARCA5, as a marker for the BRCAness phenotype.
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors.
Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53.
Molecular targeted drugs resistance impairs double-strand break repair and sensitizes ER-positive breast cancer to PARP inhibitors.
Molecular Testing in Breast Cancer.
More breast cancer patients could benefit from PARP inhibitors.
Moving beyond PARP Inhibition: Current State and Future Perspectives in Breast Cancer.
Mutant p53 mediates survival of breast cancer cells.
Network Meta-Analysis on the Effects of DNA Damage Response-Related Gene Mutations on Overall Survival of Breast Cancer Based on TCGA Database.
Network Pharmacology-Based Validation of Caveolin-1 as a Key Mediator of Ai Du Qing Inhibition of Drug Resistance in Breast Cancer.
New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy.
Next-generation sequencing-based BRCA testing on cytological specimens from ovarian cancer ascites reveals high concordance with tumour tissue analysis.
NHERF1 together with PARP1 and BRCA1 expression as a new potential biomarker to stratify breast cancer patients.
Nicotinamide sensitizes human breast cancer cells to the cytotoxic effects of radiation and cisplatin.
Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease.
Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells.
Niraparib for the treatment of ovarian cancer.
Non-NAD-Like poly(ADP-Ribose) Polymerase-1 Inhibitors effectively Eliminate Cancer in vivo.
Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors.
Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia.
Novel Poly(ADP-ribose) Polymerase-1 Inhibitor DDHCB Inhibits Proliferation of BRCA Mutant Breast Cancer Cell In Vitro and In Vivo through a Synthetic Lethal Mechanism.
Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action.
Novel synthetic triterpenoid methyl 25-hydroxy-3-oxoolean-12-en-28-oate induces apoptosis through JNK and p38 MAPK pathways in human breast adenocarcinoma MCF-7 cells.
Novel treatment strategies in triple-negative breast cancer: specific role of poly(adenosine diphosphate-ribose) polymerase inhibition.
Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer.
Nuclear PARP1 expression and its prognostic significance in breast cancer patients.
Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells.
Nuclear-cytoplasmic PARP-1 expression as an unfavorable prognostic marker in lymph node?negative early breast cancer: 15-year follow-up.
Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line.
Olaparib and ?-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial.
Olaparib for the treatment of breast cancer.
Olaparib in germline-mutated metastatic breast cancer: implications of the OlympiAD trial.
Olaparib Keeps Hereditary Breast Tumors in Check.
Olaparib monotherapy as primary treatment in unselected triple negative breast cancer.
Olaparib Suppresses MDSC Recruitment via SDF1?/CXCR4 Axis to Improve the Anti-tumor Efficacy of CAR-T Cells on Breast Cancer in Mice.
Olaparib tablets for the treatment of germ line BRCA-mutated metastatic breast cancer.
Olaparib: A Novel Therapy for Metastatic Breast Cancer in Patients With a BRCA1/2 Mutation.
ON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells.
Optimizing the management of HER2-negative metastatic breast cancer in the era of PARP inhibitors-proceedings from breast cancer expert group meeting.
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial.
Overexpression of PARP is an independent prognostic marker for poor survival in Middle Eastern breast cancer and its inhibition can be enhanced with embelin co-treatment.
Oxidative stress, DNA repair, and cancer susceptibility.
p110? and p110? isoforms of PI3K are involved in protection against H2O2 induced oxidative stress in cancer cells.
p38? mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer.
p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells.
Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells.
PARP (Poly ADP-Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer.
PARP and PARG inhibitors in cancer treatment.
PARP inhibition in breast cancer.
PARP Inhibition in Cancer: An Update on Clinical Development.
PARP inhibition in homologous-recombination-deficient early-stage breast cancer.
PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells.
PARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis.
PARP inhibitor and platinum agent in triple negative breast cancer: utilizing innovative trial design to bring together something "new" and something "old".
PARP inhibitor development for systemic cancer targeting.
PARP Inhibitor in Platinum-Resistant Ovarian Cancer: Single-Center Real-World Experience.
PARP inhibitor olaparib has a potential to increase the effectiveness of electrochemotherapy in BRCA1 mutated breast cancer in mice.
PARP inhibitor reduces proliferation and increases apoptosis in breast cancer cells.
PARP inhibitor resistance: the underlying mechanisms and clinical implications.
PARP inhibitor treatment in ovarian and breast cancer.
PARP inhibitors and more.
PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2?
PARP inhibitors and their evolving role in breast cancer.
PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers.
PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts.
PARP Inhibitors for the Treatment and Prevention of Breast Cancer.
PARP inhibitors in BRCA1/BRCA2 germline mutation carriers with ovarian and breast cancer.
PARP Inhibitors in Breast Cancer.
PARP inhibitors in breast cancer: BRCA and beyond.
PARP inhibitors in breast cancer: Bringing synthetic lethality to the bedside.
PARP Inhibitors in Breast Cancer: Why, How, and When?
PARP inhibitors in cancer therapy: promise, progress, and puzzles.
PARP inhibitors in cancer therapy: two modes of attack on the cancer cell widening the clinical applications.
PARP inhibitors in older patients with ovarian and breast cancer: Young International Society of Geriatric Oncology review paper.
PARP inhibitors in the management of breast cancer: current data and future prospects.
PARP Inhibitors in the Treatment of Early Breast Cancer: The Step Beyond?
PARP Inhibitors in Triple-Negative Breast Cancer Including Those With BRCA Mutations.
PARP inhibitors stumble in breast cancer.
PARP inhibitors--current status and the walk towards early breast cancer.
PARP inhibitor treatment of advanced breast cancer beyond the BRCA-mutated type: a meta-analysis.
PARP regulates TGF-beta receptor type II expression in estrogen receptor-positive breast cancer cell lines.
PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy.
PARP-1 inhibitors: a novel genetically specific agents for cancer therapy.
PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?
PARP-1 Regulates Estrogen-Dependent Gene Expression in Estrogen Receptor ?-Positive Breast Cancer Cells.
PARP1 and phospho-p65 protein expression is increased in human HER2-positive breast cancers.
PARP1 and PRC2 double deficiency promotes BRCA-proficient breast cancer growth by modification of the tumor microenvironment.
PARP1 Co-Regulates EP300-BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair.
PARP1 Inhibition Radiosensitizes Models of Inflammatory Breast Cancer to Ionizing Radiation.
PARP1 Inhibitors: antitumor drug design.
PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow.
PARP3 controls TGF? and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis.
PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines.
PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers.
Period-2: a tumor suppressor gene in breast cancer.
Perspectives on PARP inhibitors as pharmacotherapeutic strategies for breast cancer.
Pharmacokinetic Effects and Safety of Olaparib Administered with Endocrine Therapy: A Phase I Study in Patients with Advanced Solid Tumours.
Pharmacokinetics and clinical response to single agent rucaparib in a dialysis dependent patient with BRCA associated breast and recurrent ovarian cancer.
Pharmacologic characterization of fluzoparib, a novel poly(ADP-ribose) polymerase inhibitor undergoing clinical trials.
Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer.
Phase I and pharmacokinetic study of veliparib, a PARP inhibitor, and pegylated liposomal doxorubicin (PLD) in recurrent gynecologic cancer and triple negative breast cancer with long-term follow-up.
Phase I Study of Veliparib (ABT-888) Combined with Cisplatin and Vinorelbine in Advanced Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer.
Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.
PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA proficient triple negative breast cancer to PARP inhibition.
Poly (ADP-ribose) polymerase (PARP): rationale, preclinical and clinical evidences of its inhibition as breast cancer treatment.
Poly (ADP-ribose) polymerase inhibition enhances trastuzumab antitumour activity in HER2 overexpressing breast cancer.
Poly (ADP-ribose) Polymerase Inhibition in Patients with Breast Cancer and BRCA 1 and 2 Mutations.
Poly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond.
Poly (ADP-ribose) polymerase-1 Inhibition: Preclinical and Clinical Development of Synthetic Lethality.
Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer.
Poly(ADP-ribose) polymerase 1 (PARP1) overexpression in human breast cancer stem cells and resistance to olaparib.
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors.
Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences.
Poly(ADP-ribose) polymerase as a novel regulator of 17?-estradiol-induced cell growth through a control of the estrogen receptor/IGF-1 receptor/PDZK1 axis.
Poly(ADP-ribose) polymerase gene expression status and genomic instability in human breast cancer.
Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis.
Poly(ADP-Ribose) polymerase inhibition: "Targeted" therapy for triple-negative breast cancer.
Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer?
Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors.
Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer.
Poly(ADP-ribose) polymerase-1 mRNA expression in human breast cancer: a meta-analysis.
Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice.
Poly(ADP-ribose) polymerase-1 promotes recruitment of meiotic recombination-11 to chromatin and DNA double-strand break repair in Ku70-deficient breast cancer cells.
Poly-(ADP-ribose) polymerase inhibitors: paradigm shift in the first-line treatment of newly diagnosed advanced ovarian cancer.
Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells.
Polyclonal BRCA2 mutations following carboplatin treatment confer resistance to the PARP inhibitor rucaparib in a patient with mCRPC: a case report.
Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.
Polymorphisms in poly (ADP-ribose) polymerase-1 (PARP1) promoter and 3' untranslated region and their association with PARP1 expression in breast cancer patients.
Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Glu and risk of breast cancer in Chinese women: a case control analysis.
PPAR?-inactive ?2-troglitazone independently triggers ER stress and apoptosis in breast cancer cells.
Prognostic and clinicopathological value of poly (adenosine diphosphate-ribose) polymerase expression in breast cancer: A meta-analysis.
Prolonged response to treatment based on cell-free DNA analysis and molecular profiling in three patients with metastatic cancer: a case series.
Prosopis juliflora (Sw.), DC induces apoptosis and cell cycle arrest in triple negative breast cancer cells: in vitro and in vivo investigations.
Prospect for Application of PARP Inhibitor in Patients with HER2 Negative Breast Cancer.
Proteasome ubiquitin receptor PSMD4 is an amplification target in breast cancer and may predict sensitivity to PARPi.
Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4.
PTK6 regulates growth and survival of endocrine therapy-resistant ER+ breast cancer cells.
Pyrosequencing analysis of BRCA1 methylation level in breast cancer cells.
RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment.
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.
Rad51 inhibition sensitizes breast cancer stem cells to PARP inhibitor in triple-negative breast cancer.
RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer.
Radiosensitization with combined use of olaparib and PI-103 in triple-negative breast cancer.
Randomised phase II trial of olaparib, chemotherapy or olaparib and cediranib in patients with platinum-resistant ovarian cancer (OCTOVA): a study protocol.
Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.
Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.
Rapid Progression of Metastatic Pancreatic Adenocarcinoma During Platinum-Based Therapy in a Patient Harboring a Pathogenic BRCA2 Germline Variant.
Rare mutations in XRCC2 increase the risk of breast cancer.
RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells.
Recent Advances in Enhancing the Therapeutic Index of PARP Inhibitors in Breast Cancer.
Recent developments in treatment stratification for metastatic breast cancer.
Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition.
Relevance of poly (ADP-ribose) polymerase inhibitors in prostate cancer.
Response of Breast Cancer Cells to PARP Inhibitors Is Independent of BRCA Status.
Response of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition.
Response to Olaparib in a Patient with Germline BRCA2 Mutation and Breast Cancer Leptomeningeal Carcinomatosis.
Response to olaparib in metastatic castration-resistant prostate cancer with germline BRCA2 mutation: a case report.
Resurrection of PARP Inhibitors in Breast Cancer.
Resveratrol enhances the efficacy of sorafenib mediated apoptosis in human breast cancer MCF7 cells through ROS, cell cycle inhibition, caspase 3 and PARP cleavage.
Resveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3-dependent pathway.
Resveratrol-induced growth inhibition in MDA-MB-231 breast cancer cells is associated with mitogen-activated protein kinase signaling and protein translation.
Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer.
RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance.
Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.
Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors.
Role of Poly (ADP-Ribose) Polymerase inhibitors beyond BReast CAncer Gene-mutated ovarian tumours: definition of homologous recombination deficiency?
Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment.
Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.
Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation.
Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status.
Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan.
Sequences and combinations of multifaceted therapy in advanced prostate cancer.
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.
Should Tumor Infiltrating Lymphocytes, Androgen Receptor, and FOXA1 Expression Predict the Clinical Outcome in Triple Negative Breast Cancer Patients?
Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells.
Simple prediction model for homologous recombination deficiency in breast cancers in adolescents and young adults.
Single-agent PARP inhibitors for the treatment of patients with BRCA-mutated HER2-negative metastatic breast cancer: a systematic review and meta-analysis.
Somatic mutations in the BRCA1 gene in Chinese women with sporadic breast cancer.
Somatostatin receptor targeted liposomes with Diacerein inhibit IL-6 for breast cancer therapy.
Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance.
Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors.
Stumbling blocks on the path to personalized medicine in breast cancer: the case of PARP inhibitors for BRCA1/2-associated cancers.
Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines.
Suppression of survival in human SKBR3 breast carcinoma in response to metal-chelator complexes is preferential for copper-dithiocarbamate.
Survival benefits of PARP inhibitors in advanced breast cancer: a mirage?
Sustained Cytotoxicity of Wogonin on Breast Cancer Cells by Encapsulation in Solid Lipid Nanoparticles.
Synergistic Effect of Bazedoxifene and PARP Inhibitor in the Treatment of Ovarian Cancer Regardless of BRCA Mutation.
Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines.
Synergy of theophylline reduces necrotic effect of berberine, induces cell cycle arrest and PARP, HMGB1, Bcl-2 family mediated apoptosis in MDA-MB-231 breast cancer cells.
Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study.
Synthesis of Some Benzimidazole-derived Molecules and Their Effects on PARP-1 Activity and MDA-MB-231, MDA-MB-436, MDA-MB-468 Breast Cancer Cell Viability.
Synthesis, biological evaluation and molecular docking studies of novel 1,2,3-triazole-quinazolines as antiproliferative agents displaying ERK inhibitory activity.
Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells.
Synthesis, cytotoxic evaluation and molecular docking study of novel quinazoline derivatives as PARP-1 inhibitors.
Synthetic lethal interactions between EGFR and PARP inhibition in human triple negative breast cancer cells.
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.
Synthetic lethal therapies for cancer: what's next after PARP inhibitors?
Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer.
Systematic comparison of ligand-based and structure-based virtual screening methods on poly (ADP-ribose) polymerase-1 inhibitors.
Systems biology approaches based discovery of a small molecule inhibitor targeting both c-Met/PARP-1 and inducing cell death in breast cancer.
Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells.
Tanshinone IIA Induces Mitochondria Dependent Apoptosis in Prostate Cancer Cells in Association with an Inhibition of Phosphoinositide 3-Kinase/AKT Pathway.
Targeted radiosensitization with PARP1 inhibition: optimization of therapy and identification of biomarkers of response in breast cancer.
Targeted Therapies for Breast Cancer Brain Metastases.
Targeted Therapies for Triple-Negative Breast Cancer.
Targeted therapy in breast cancer: what's new?
Targeted therapy of metastatic breast cancer.
Targeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-ribose) polymerase inhibition.
Targeting DNA repair in breast cancer.
Targeting DNA repair in breast cancer: A clinical and translational update.
Targeting PARP1 in XRCC1 deficient sporadic invasive breast cancer or pre-invasive ductal carcinoma in situ induces synthetic lethality and chemoprevention.
TBCRC 048: Phase II Study of Olaparib for Metastatic Breast Cancer and Mutations in Homologous Recombination-Related Genes.
TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP), A Novel Therapeutic Target Of Breast Cancer.
TGF? induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes.
The C Allele of a Synonymous SNP (rs1805414, Ala284Ala) in PARP1 is a Risk Factor for Susceptibility to Breast Cancer in Saudi Patients.
The CDK1 inhibitor RO3306 improves the response of BRCA-pro?cient breast cancer cells to PARP inhibition.
The cyclin-dependent kinase inhibitor SNS-032 induces apoptosis in breast cancer cells via depletion of Mcl-1 and X-linked inhibitor of apoptosis protein and displays antitumor activity in vivo.
The diagnostic value of DNA repair gene in breast cancer metastasis.
The emerging potential of poly(ADP-ribose) polymerase inhibitors in the treatment of breast cancer.
The evolution of poly(ADP-ribose) polymerase inhibitors in the treatment of breast cancer.
The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome.
The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.
The implications of BRCA loss of heterozygosity (LOH) and deficient mismatch repair gene (dMMR) expression in the breast cancer of a patient with both inherited breast and ovarian cancer syndrome (BRCA2) and Lynch syndrome (MLH1).
The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors.
The nuclear expression of poly (ADP-ribose) polymerase-1 (PARP1) in invasive primary breast tumors is associated with chemotherapy sensitivity.
The OlympiAD trial: who won the gold?
The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks.
The PARP inhibitor AZD2281 (Olaparib) induces autophagy/mitophagy in BRCA1 and BRCA2 mutant breast cancer cells.
The Poly (ADP-Ribose) Polymerase Inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells.
The potential of PARP inhibitors in genetic breast and ovarian cancers.
The Prognostic and Predictive Significance of PARP-1 in Locally Advanced Breast Cancer of Egyptian Patients Receiving Neoadjuvant Chemotherapy.
The promise of combining inhibition of PI3K and PARP as cancer therapy.
The Real Impact of Target Therapy in Breast Cancer Patients: Between Hope and Reality.
The role of Kif4A in doxorubicin-induced apoptosis in breast cancer cells.
The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes.
The role of novel poly (ADP-ribose) inhibitors in the treatment of locally advanced and metastatic Her-2/neu negative breast cancer with inherited germline BRCA1/2 mutations. A review of the literature.
The role of PARP inhibition in triple-negative breast cancer: Unraveling the wide spectrum of synthetic lethality.
The Role of PARPs in Inflammation-and Metabolic-Related Diseases: Molecular Mechanisms and Beyond.
The synthetic ?-nitrostyrene derivative CYT-Rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway.
The triple-negative subtype: new ideas for the poorest prognosis breast cancer.
The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange.
The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy-Current progress and future direction.
Therapeutic innovations in breast cancer.
Therapeutic potential of PARP inhibitors for metastatic breast cancer.
Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer.
TNFR2 promotes Adriamycin resistance in breast cancer cells by repairing DNA damage.
Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity.
Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23.
Transcriptional dysregulation of base excision repair proteins in breast cancer.
Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer.
Translational highlights in breast cancer research and treatment: recent developments with clinical impact.
Trastuzumab resistant HER2+ breast cancer cells retain sensitivity to poly (ADP-ribose) polymerase (PARP) inhibition.
Treating breast cancer in the 21st century: emerging biological therapies.
Triple negative breast cancer: Emerging therapeutic modalities and novel combination therapies.
Triple-negative breast cancer and Poly(ADP-ribose) polymerase inhibitors.
Triptolide sensitizes human breast cancer cells to tumor necrosis factor???induced apoptosis by inhibiting activation of the nuclear factor??B pathway.
Tumor-suppressive effect of adenovirus-mediated inhibitor of growth 4 gene transfer in breast carcinoma cells in vitro and in vivo.
Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.
Update Breast Cancer 2020 Part 2 - Advanced Breast Cancer: New Treatments and Implementation of Therapies with Companion Diagnostics.
Update on PARP Inhibitors in Breast Cancer.
Using multiple targeted therapies in oncology: considerations for use, and progress to date in breast cancer.
VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth.
Veliparib in ovarian cancer: a new synthetically lethal therapeutic approach.
Verrucarin A alters cell-cycle regulatory proteins and induces apoptosis through reactive oxygen species-dependent p38MAPK activation in the human breast cancer cell line MCF-7.
Where Do We Stand on the Integration of PARP Inhibitors for the Treatment of Breast Cancer?
Wise Management of Ovarian Cancer: On the Cutting Edge.
Withanolide C Inhibits Proliferation of Breast Cancer Cells via Oxidative Stress-Mediated Apoptosis and DNA Damage.
XRCC1 and ADPRT polymorphisms associated with survival in breast cancer cases treated with chemotherapy.
XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib.
Zebrafish Xenografts Unveil Sensitivity to Olaparib beyond BRCA Status.
[(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer.
[18F]-SuPAR: A Radiofluorinated Probe for Noninvasive Imaging of DNA Damage-Dependent Poly(ADP-ribose) Polymerase Activity.
[Breakthrough breast cancer treatment--PARP inhibitor, BRCA, and triple negative breast cancer]
[Effects of Olaparib, a PARP-1 Inhibitor, on Triple Negative Breast Cancer Cells with a BRCA1 Mutation].
[From poly(ADP-ribose) discovery to PARP inhibitors in cancer therapy].
[Hereditary Breast and Ovarian Cancer Syndrome].
[Hereditary breast carcinomas pathologist's perspective].
[Learning from My Experience: Outpatient Care for Cancer Multigene Genomic Testing].
[New advances in targeted therapy for breast cancer].
[New targeted therapies in breast cancer].
[Olaparib potentiates the antitumor effect of Taxol on 4T1 breast cancer].
[On the prospects of using the DNA repair inhibitors in radiotherapy of tumors].
[PARP inhibitors and breast cancer: update and perspectives].
[PARP inhibitors in breast cancer: Current clinical development and perspectives].
[PARP inhibitors--theoretical basis and clinical application].
[The Role of Preoperative Chemotherapy Depending on Breast Cancer Subtype].
Bronchiolitis
Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms.
Burkitt Lymphoma
Biological Effects of MC2050, a Quinazoline-Based PARP-1 Inhibitor, in Human Neuroblastoma and EBV-Positive Burkitt's Lymphoma Cells.
Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk.
IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors.
PARP1 Is Overexpressed in Hematological Malignant Cell Lines: A Framework for Experimental Oncology.
Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1.
Prolongation of the p53 response to DNA strand breaks in cells depleted of PARP by antisense RNA expression.
Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents.
The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma.
Calcinosis
Calcinosis in Systemic Sclerosis: Updates in Pathophysiology, Evaluation, and Treatment.
Carcinogenesis
Advanced small cell lung cancer (SCLC): new challenges and new expectations.
Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients.
Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells.
Asbestos exposure affects poly(ADP-ribose) polymerase-1 activity: role in asbestos-induced carcinogenesis.
Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis.
Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes.
Beyond DNA Repair: Additional Functions of PARP-1 in Cancer.
Chemopreventive effect of hesperidin, a citrus bioflavonoid in two stage skin carcinogenesis in Swiss albino mice.
Common and unique genetic interactions of the poly(ADP-ribose) polymerases PARP1 and PARP2 with DNA double-strand break repair pathways.
Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia.
Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless mice.
Cytoplasmic PARP-1 promotes pancreatic cancer tumorigenesis and resistance.
Defective control of mitotic and post-mitotic checkpoints in poly(ADP-ribose) polymerase-1(-/-) fibroblasts after mitotic spindle disruption.
Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice.
DNA double-strand break repair pathway choice - from basic biology to clinical exploitation.
DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.
Effect of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in patients with colorectal cancer.
Enhancement of DEN initiation of liver carcinogenesis by inhibitors of NAD+ ADP ribosyl transferase in rats.
Ex vivo study of MAPK profiles correlated with parameters of apoptosis during cervical carcinogenesis.
Expression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV).
Expression of the Gene Encoding Poly(ADP-ribose) Polymerase-1 Is Modulated by Fibronectin during Corneal Wound Healing.
Functional Characterization of Long Noncoding RNA Lnc_bc060912 in Human Lung Carcinoma Cells.
Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death.
Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors.
Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis.
Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family.
H2AX a promising biomarker for lung cancer: a review.
Identification and Characterization of MortaparibPlus-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms.
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity.
Inhibition of methylazoxymethanol acetate initiation of colon carcinogenesis in rats by treatment with the poly(ADP-ribose)polymerase inhibitor 3-aminobenzamide.
Inhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression.
Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene.
Inhibition of poly(ADP-ribose) polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice.
Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis.
Interaction among susceptibility genotypes of PARP1 SNPs in thyroid carcinoma.
Involvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis.
Knockdown of PARP-1 Inhibits Proliferation and ERK Signals, Increasing Drug Sensitivity in Osteosarcoma U2OS Cells.
Loss of PIDD limits NF-?B activation and cytokine production but not cell survival or transformation after DNA damage.
Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice.
Mechanism of early biphasic activation of poly(ADP-ribose) polymerase-1 in response to ultraviolet B radiation.
Modulation of brain tumor risk by genetic SNPs in PARP1gene: Hospital based case control study.
Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver.
Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation.
Molecular/Genetic therapies in ovarian cancer: future opportunities and challenges.
New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy.
Nicotinamide Phosphoribosyltransferase in Malignancy: A Review.
Non-NAD-like PARP-1 inhibitors in prostate cancer treatment.
Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: evidence for increased tumor cell apoptosis in vivo.
Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis.
PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions.
PARP-1 activity in normal and cancerous human endometrium and its relationship with quantity of abasic sites (AP).
Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice.
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts.
Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.
Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment.
Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer.
PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.
PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesis.
PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population.
PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies.
PARP-1-dependent 3-nitrotyrosine protein modification after DNA damage.
PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.
PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair.
PARP1 Gene Polymorphisms and the Prognosis of Esophageal Cancer Patients from Cixian High-Incidence Region in Northern China.
PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin.
PARP1 rs1136410 (A/G) polymorphism is associated with early age of onset of gallbladder cancer.
PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress.
PARP14 promotes the proliferation and gemcitabine chemoresistance of pancreatic cancer cells through activation of NF-?B pathway.
PARP3 interacts with FoxM1 to confer glioblastoma cell radioresistance.
Poly(ADP-ribose) polymerase gene on chromosome 1q: early role in differentiation linked replication; gene on human chromosome 13q: marker of carcinogenesis.
Poly(ADP-ribose) polymerase-1 inhibition by arsenite promotes the survival of cells with unrepaired DNA lesions induced by UV exposure.
Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.
Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice.
Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis.
Poly(ADP-ribose)polymerase-1 (PARP-1) in carcinogenesis: potential role of PARP inhibitors in cancer treatment.
Poly(ADP-ribosyl)ation and aging.
PolyADP-ribosylation and cancer.
Possible role of poly(ADP-ribose) polymerase on the early stage of liver carcinogenesis by diethylnitrosamine in rats.
RecQ helicases and PARP1 team up in maintaining genome integrity.
Regulation of the poly(ADP-ribose) polymerase-1 gene expression by the transcription factors Sp1 and Sp3 is under the influence of cell density in primary cultured cells.
Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences.
Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis.
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.
Tannins elevate the level of poly(ADP-ribose) in HeLa cell extracts.
Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer.
The beneficial effects of dietary restriction: reduced oxidative damage and enhanced apoptosis.
The emerging role of poly(ADP-ribose) polymerase-1 in longevity.
The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly(ADP-ribosyl)ation Activity in Cancer Cells.
The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis.
The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm.
The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression.
Therapeutic Targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities.
TiPARP forms nuclear condensates to degrade HIF-1? and suppress tumorigenesis.
Transcript response of soft coral (Scleronephthya gracillimum) on exposure to polycyclic aromatic hydrocarbons.
Two DNA repair gene polymorphisms on the risk of gastrointestinal cancers: a meta-analysis.
Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types.
Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.
[Diethylnitrosamine-induced carcinogenesis in PARP-1(-/-) and PARP-1(+/+) mice]
[DNA damage in human peripheral blood lymphocyte caused by nickel and cadmium]
[Features of carcinogenesis and aging in knockout male mice PARP-1]
[Poly(ADP-ribosa)polymerase--the relationships with life span and carcinogenesis]
Carcinoid Tumor
MG-132 Inhibits Carcinoid Growth and Alters the Neuroendocrine Phenotype.
The PARP inhibitor ABT-888 potentiates dacarbazine-induced cell death in carcinoids.
Carcinoma
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A phase I trial adding poly(ADP-ribose) polymerase inhibitor veliparib to induction carboplatin-paclitaxel in patients with head and neck squamous cell carcinoma: Alliance A091101.
A Phase I-II Study of the Oral Poly(ADP-ribose) Polymerase Inhibitor Rucaparib in Patients with Germline BRCA1/2-mutated Ovarian Carcinoma or Other Solid Tumors.
A profile on the FoundationFocus CDxBRCA tests.
Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma.
Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage.
Anti-Cancer Effect of Quercetin in Xenograft Models with EBV-Associated Human Gastric Carcinoma.
Antimicrobial cyclic decapeptides with anticancer activity.
Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2.
Antitumor efficacy of PARP inhibitors in homologous recombination deficient carcinomas.
Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma.
Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population.
ATARI trial: ATR inhibitor in combination with olaparib in gynecological cancers with ARID1A loss or no loss (ENGOT/GYN1/NCRI).
Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells.
Autophagy suppression enhances DNA damage and cell death upon treatment with PARP inhibitor Niraparib in laryngeal squamous cell carcinoma.
Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy.
BRCA Methylation Testing Identifies a Subset of Ovarian Carcinomas without Germline Variants That Can Benefit from PARP Inhibitor.
BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.
BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance.
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.
Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA.
c-Abl Is an Upstream Regulator of Acid Sphingomyelinase in Apoptosis Induced by Inhibition of Integrins ?v?3 and ?v?5.
c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-{beta}-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells.
Candidate Markers of Olaparib Response from Genomic Data Analyses of Human Cancer Cell Lines.
Cellular and biochemical antileukemic mechanisms of the meroterpenoid Oncocalyxone A.
Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor.
Cisplatin benefit is predicted by immunohistochemical analysis of DNA repair proteins in squamous cell carcinoma but not adenocarcinoma: theranostic modeling by NSCLC constituent histological subclasses.
Clinical Impact of Somatic Variants in Homologous Recombination Repair-Related Genes in Ovarian High-Grade Serous Carcinoma.
Combination therapy in advanced urothelial cancer: the role of PARP, HER-2 and mTOR inhibitors.
Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models.
Comparative evaluation of antiproliferative, antiangiogenic and apoptosis inducing potential of black tea polyphenols in the hamster buccal pouch carcinogenesis model.
Correction to: Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN.
Cytoplasmic EBP50 and elevated PARP1 are unfavorable prognostic factors in ovarian clear cell carcinoma.
Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas.
Design, synthesis, and anticancer evaluation of long-chain alkoxylated mono-carbonyl analogues of curcumin.
Development of Olaparib for BRCA-Deficient Recurrent Epithelial Ovarian Cancer.
Development of poly ADP-ribose polymerase-1 inhibitor with anti-cervical carcinoma activity.
Differential radiosensitization by the poly(ADP-ribose) transferase inhibitor 3-aminobenzamide in human tumor cells of varying radiosensitivity.
Discovery and Structure-Activity Relationships of Modified Salicylanilides as Cell Permeable Inhibitors of Poly(ADP-ribose) Glycohydrolase (PARG).
DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.
Dual disruption of DNA repair and telomere maintenance for the treatment of head and neck cancer.
Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines.
Effect of cisplatin on metastatic castration-resistant prostate cancer with BRCA2 mutation: A case report.
Effect of PARP Inhibitors as Maintenance Treatment on Restricted Mean Survival Time in Platinum-Sensitive Recurrent Ovarian Cancer: A Systematic Review and Meta-analysis.
Effect of Poly (ADP-ribose) Polymerase-1 Inhibition on the Proliferation of Murine Colon Carcinoma CT26 Cells.
Effects of pertussis toxin on signal transductions via P2-purinergic receptors in A-431 human epidermoidal carcinoma cells.
Efficacy and safety of rucaparib in previously treated, locally advanced or metastatic urothelial carcinoma from a phase 2, open-label trial (ATLAS).
Epigenetic Treatment of Urothelial Carcinoma Cells Sensitizes to Cisplatin Chemotherapy and PARP Inhibitor Treatment.
ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer.
Evidence for the efficacy of Iniparib, a PARP-1 inhibitor, in BRCA2-associated pancreatic cancer.
Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis.
Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor.
Expression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV).
Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas.
Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas.
Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein.
Flavone inhibition of tumor growth via apoptosis in vitro and in vivo.
Fluorescence-guided resection of tumors in mouse models of oral cancer.
Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck.
Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes.
Heterogeneous nuclear ribonucleoprotein U-like 1 and Poly (ADP-ribose) polymerase 1 are downregulated in renal cell carcinoma and connected with the prognosis.
Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma.
Identification of miRNA modulators to PARP inhibitor response.
Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies.
Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors.
Immunohistochemistry expression of targeted therapies biomarkers in ovarian clear cell and endometrioid carcinomas (type I) and endometriosis.
In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma.
Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints.
Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer.
Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan.
Influence of pertussis toxin on superficial bladder carcinoma in rats.
Inhibition of arginine ADP-ribosyltransferase 1 reduces the expression of poly(ADP-ribose) polymerase-1 in colon carcinoma.
Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma.
Inhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.
Intrinsic presence of poly (ADP-ribose) is significantly increased in malignant prostate compared to benign prostate cell lines.
Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer.
Levels of superoxide dismutases, glutathione, and poly(ADP-ribose) polymerase in radioresistant human KB carcinoma cell line.
Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells.
Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition.
Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN.
Mainstreaming germline BRCA1/2 testing in non-mucinous epithelial ovarian cancer in the North West of England.
Male rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity.
MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer.
MBP-1 mediated apoptosis involves cytochrome c release from mitochondria.
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma.
Mitochondrial DNA depletion reduces PARP-1 levels and promotes progression of the neoplastic phenotype in prostate carcinoma.
Mitochondrial DNA depletion sensitizes cancer cells to PARP inhibitors by translational and post-translational repression of BRCA2.
Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2).
Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas.
New insights on the pathogenesis of ovarian carcinoma: molecular basis and clinical implications.
Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas.
Optical Imaging of PARP1 in Response to Radiation in Oral Squamous Cell Carcinoma.
Ovarian Serous Carcinoma With a Novel HSP90AB1 Mutation in a Patient With Synchronous Primary Fallopian Tube Serous Carcinoma.
Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells.
Overexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer.
p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review.
PARG regulates the proliferation and differentiation of DCs and T cells via PARP/NF??B in tumour metastases of colon carcinoma.
PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells.
PARP inhibition enhances radiotherapy of SMAD4 deficient human head and neck squamous cell carcinomas in experimental models.
PARP inhibitor olaparib sensitizes esophageal carcinoma cells to fractionated proton irradiation.
PARP inhibitors and radiation potentiate liver cell death in vitro. Do hepatocellular carcinomas have an achilles' heel?
PARP Inhibitors for Recurrent Ovarian Carcinoma: Current Treatment Options and Future Perspectives.
PARP inhibitors: A new era of targeted therapy.
PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma.
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts.
PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy.
PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1.
PARP-1 induces EMT in non-small cell lung carcinoma cells via modulating the transcription factors Smad4, p65 and ZEB1.
PARP-1 Val762Ala polymorphism is associated with reduced risk of non-Hodgkin lymphoma in Korean males.
PARP-1 Val762Ala polymorphism is associated with risk of cervical carcinoma.
PARP1 and CASP3 gene expression in a patient with multiple head and neck squamous cell carcinoma and Parkinson disease.
PARP1 Gene Polymorphisms and the Prognosis of Esophageal Cancer Patients from Cixian High-Incidence Region in Northern China.
PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs.
PARP1 rs1136410 C/C genotype associated with an increased risk of esophageal cancer in smokers.
Pharmacological Inhibition of Poly(ADP-ribose) Polymerase (PARP) Activity in PARP-1 Silenced Tumour Cells Increases Chemosensitivity to Temozolomide and to a N3-Adenine Selective Methylating Agent.
Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent.
PK11195, an isoquinoline carboxamide ligand of the mitochondrial benzodiazepine receptor, increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro.
Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer.
Poly (ADP-Ribose) Polymerase Inhibitor, ABT888, Improved Cisplatin Effect in Human Oral Cell Carcinoma.
Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma.
Poly ADP-ribose polymerase-1 as a potential therapeutic target in Merkel cell carcinoma.
Poly(adenosine diphosphate-ribose) polymerase expression in BRCA-proficient ovarian high-grade serous carcinoma; association with patient survival.
Poly(adenosine diphosphate-ribose) polymerase expression in serous ovarian carcinoma: correlation with p53, MIB-1, and outcome.
Poly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues.
Poly(ADP-ribose) polymerase (PARP) inhibitors as treatment versus maintenance in ovarian carcinoma.
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors.
Poly(ADP-ribose) polymerase activity in proliferating and quiescent murine mammary carcinoma cells.
Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells.
Poly(ADP-ribose) polymerase signaling of topoisomerase 1-dependent DNA damage in carcinoma cells.
Poly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells.
Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation.
Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice.
Poly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors.
Poly-ADP-ribosyl-polymerase inhibitor resistance mechanisms and their therapeutic implications.
Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer.
Prevalence of germline pathogenic BRCA1/2 variants in sequential epithelial ovarian cancer cases.
Prevalence of hereditary breast and ovarian cancer (HBOC) predisposition gene mutations among 882 HBOC high-risk Chinese individuals.
Prevention of oxidant-induced cell death in Caco-2 colon carcinoma cells after inhibition of poly(ADP-ribose) polymerase and Ca2+ chelation: involvement of a common mechanism.
Prolonged response to treatment based on cell-free DNA analysis and molecular profiling in three patients with metastatic cancer: a case series.
Promising anti- cervical carcinoma and inflammatory agent, Resveratrol targets poly (ADP-ribose) polymerase 1 (PARP-1) induced premature ovarian failure with a potent enzymatic modulatory activity.
Radiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer Vaccine.
Radiosensitization by the PARP inhibitor olaparib in BRCA1-proficient and deficient high-grade serous ovarian carcinomas.
Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Ras(V12) induces Survivin/AuroraB pathway conferring tumor cell apoptosis resistance.
Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase.
RIG-I enhanced interferon independent apoptosis upon Junin virus infection.
Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.
Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.
Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma.
Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.
Silencing of CHFR Sensitizes Gastric Carcinoma to PARP Inhibitor Treatment.
Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages.
Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK.
Spatiotemporal activation of caspase-dependent and -independent pathways in staurosporine-induced apoptosis of p53wt and p53mt human cervical carcinoma cells.
Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo.
Synergistic Anti-Tumour Effect of Syk Inhibitor and Olaparib in Squamous Cell Carcinoma: Roles of Syk in EGFR Signalling and PARP1 Activation.
Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells.
Systemic treatment for hereditary cancers: a 2012 update.
Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience.
Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines.
Targeted blockade of HSP90 impairs DNA-damage response proteins and increases the sensitivity of ovarian carcinoma cells to PARP inhibition.
The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer.
The CHK1 inhibitor SRA737 synergizes with PARP1 inhibitors to kill carcinoma cells.
The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity.
The Emerging Role of Poly (ADP-Ribose) Polymerase Inhibitors as Effective Therapeutic Agents in Renal Cell Carcinoma.
The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide.
The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the La-specific antibody APOMAB®.
The Prognostic Value of BRCA1 and PARP Expression in Epithelial Ovarian Carcinoma: Immunohistochemical Detection.
The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas.
The Role of PARP Inhibitors in the Treatment of Ovarian Carcinomas.
The TLR7/8/9 antagonist IMO-8503 inhibits cancer-induced cachexia.
Triptolide induces s phase arrest and apoptosis in gallbladder cancer cells.
Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts.
Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers.
Valproate augments Niraparib killing of tumor cells.
Xanthorrhizol Induces Apoptosis Through ROS-Mediated MAPK Activation in Human Oral Squamous Cell Carcinoma Cells and Inhibits DMBA-Induced Oral Carcinogenesis in Hamsters.
[BRCA1 and BRCA2 - pathologists starting kit].
[Hereditary breast and ovarian cancers].
[Il ruolo di niraparib nel trattamento del carcinoma ovarico: attualità e prospettive.]
[Inhibitory effect of 5-aminoisoquinolinone on PARP activity in colon carcinoma cell line HT-29]
[Oncopathological aspects of BRCA1 and BRCA2 genes inactivation in tumors of ovary, fallopian tube and pelvic peritoneum].
[The effect of tanshinone ?A potentiates the effects of Cisplatin in Fadu cells in vitro through downregulation of survivin].
Carcinoma, Acinar Cell
Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review.
Carcinoma, Adenoid Cystic
Prolonged response to treatment based on cell-free DNA analysis and molecular profiling in three patients with metastatic cancer: a case series.
Carcinoma, Basal Cell
PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma.
Carcinoma, Ductal
BRCA1 and PARP1 mRNA expression during progression from normal breast to ductal carcinoma in situ and invasive breast cancer: a laser microdissection study.
Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer.
Targeting PARP1 in XRCC1 deficient sporadic invasive breast cancer or pre-invasive ductal carcinoma in situ induces synthetic lethality and chemoprevention.
Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types.
Carcinoma, Ehrlich Tumor
NAD[S], an NAD analogue with reduced susceptibility to phosphodiesterase. Chemical synthesis and enzymic properties.
Poly(ADP-ribose) polymerase from Ehrlich ascites tumor cells. Properties of the purified polymerase.
Purification of poly(ADP-ribose) polymerase from Ehrlich ascites tumor cells by chromatography on DNA-agarose.
Carcinoma, Embryonal
PARP expression in germ cell tumours.
Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition.
Carcinoma, Endometrioid
Immunohistochemistry expression of targeted therapies biomarkers in ovarian clear cell and endometrioid carcinomas (type I) and endometriosis.
Poly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues.
Carcinoma, Hepatocellular
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
6,(5H)-phenanthridinone protects against carbon tetrachloride-induced cytotoxicity in human HepG2 cells.
Arsenite-loaded nanoparticles inhibit PARP-1 to overcome multidrug resistance in hepatocellular carcinoma cells.
Autophagy suppresses radiation damage by activating PARP-1 and attenuating reactive oxygen species in hepatoma cells.
Chemopreventive action of Lygodium flexuosum extract in human hepatoma PLC/PRF/5 and Hep 3B cells.
Cloning and expression of cDNA for human poly(ADP-ribose) polymerase.
Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14).
Conjugated linoleic acid isomers and trans fatty acids inhibit fatty acid transport in hepatoma 7288CTC and inguinal fat pads in Buffalo rats.
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma.
Enhancement of cell permeabilization apoptosis-inducing activity of selenium nanoparticles by ATP surface decoration.
EP1 Prostanoid Receptor Coupling to Gi/o Upregulates the Expression of Hypoxia-Inducible Factor-1{alpha} Through Activation of a Phosphoinositide-3 Kinase Signaling Pathway.
Expression of poly(ADP-ribose) polymerase in human hepatocellular carcinoma and analysis of biopsy specimens obtained under sonographic guidance.
Global proteomic profiling in multistep hepatocarcinogenesis and identification of PARP1 as a novel molecular marker in hepatocellular carcinoma.
Hepatoma cell-intrinsic TLR9 activation induces immune escape through PD-L1 upregulation in hepatocellular carcinoma.
Human alcohol dehydrogenase 1 is an acceptor protein for polyADP-ribosylation.
Identification of poly(ADP-ribose) polymerase-1 as a cell cycle regulator through modulating Sp1 mediated transcription in human hepatoma cells.
Induction of apoptosis in normal cultured rat hepatocytes and in Hep3B, a human hepatoma cell line.
Inhibited effects of veliparib combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line.
Inhibition of Poly(ADP-Ribose) Polymerase Increased Lipid Accumulation Through SREBP1 Modulation.
Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro.
Interaction of hepatitis B virus X protein with PARP1 results in inhibition of DNA repair in hepatocellular carcinoma.
Isolation of 4,4'-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma.
Macrophage mediated anti-proliferation effects of Anthodia camphorata non-polysaccharide based extracts on human hepatoma cells.
Mechanism for the antitumor and anticachectic effects of n-3 fatty acids.
Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway.
Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells.
MicroRNA-31-5p regulates chemosensitivity by preventing the nuclear location of PARP1 in hepatocellular carcinoma.
MK5 is degraded in response to doxorubicin and negatively regulates doxorubicin-induced apoptosis in hepatocellular carcinoma cells.
Momordin Ic induces HepG2 cell apoptosis through MAPK and PI3K/Akt-mediated mitochondrial pathways.
New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity.
NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma.
No associations of polymorphisms in ADPRT with hepatitis B virus clearance and hepatocellular carcinoma occurrence in a Korean population.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP inhibition and the radiosensitizing effects of the PARP inhibitor ABT-888 in in vitro hepatocellular carcinoma models.
PARP inhibitor Olaparib overcomes Sorafenib resistance through reshaping the pluripotent transcriptome in hepatocellular carcinoma.
PARP inhibitors and radiation potentiate liver cell death in vitro. Do hepatocellular carcinomas have an achilles' heel?
PARP-1 inhibitor sensitizes arsenic trioxide in hepatocellular carcinoma cells via abrogation of G2/M checkpoint and suppression of DNA damage repair.
PARP-1 promotes tumor recurrence after warm ischemic liver graft transplantation via neutrophil recruitment and polarization.
PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population.
PARP10 suppresses tumor metastasis through regulation of Aurora A activity.
PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation.
Pertussis Toxin, an Inhibitor of G(?i) PCR, Inhibits Bile Acid- and Cytokine-Induced Apoptosis in Primary Rat Hepatocytes.
Pinus kesiya Royle ex Gordon induces apoptotic cell death in hepatocellular carcinoma HepG2 cell via intrinsic pathway by PARP and Topoisomerase I suppression.
PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells.
PLK1/NF-?B feedforward circuit antagonizes the mono-ADP-ribosyltransferase activity of PARP10 and facilitates HCC progression.
Poly (ADP-ribose) polymerase inhibition synergizes with the NF-?B inhibitor DHMEQ to kill hepatocellular carcinoma cells.
Poly(ADP-ribose) synthase is the major endogenous nonhistone acceptor for poly(ADP-ribose) in alkylated rat hepatoma cells.
Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway.
Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.
Retraction Note: MicroRNA-31-5p regulates chemosensitivity by preventing the nuclear location of PARP1 in hepatocellular carcinoma.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Targeting PARP and autophagy evoked synergistic lethality in hepatocellular carcinoma.
The assessment of an in-vitro model for evaluating the role of PARP in ethanol-mediated hepatotoxicity.
The long noncoding RNA lncPARP1 contributes to progression of hepatocellular carcinoma through up-regulation of PARP1.
Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.
Update on hepatocellular carcinoma breakthroughs: Poly(ADP-ribose) polymerase inhibitors as a promising therapeutic strategy.
[Role of proteins in Fas-mediated apoptosis in tumor cells and lymphocytes co-cultured in vitro]
Carcinoma, Intraductal, Noninfiltrating
BRCA1 and PARP1 mRNA expression during progression from normal breast to ductal carcinoma in situ and invasive breast cancer: a laser microdissection study.
Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer.
Targeting PARP1 in XRCC1 deficient sporadic invasive breast cancer or pre-invasive ductal carcinoma in situ induces synthetic lethality and chemoprevention.
Carcinoma, Lewis Lung
The TLR7/8/9 antagonist IMO-8503 inhibits cancer-induced cachexia.
Carcinoma, Merkel Cell
Poly ADP-ribose polymerase-1 as a potential therapeutic target in Merkel cell carcinoma.
Carcinoma, Neuroendocrine
Evaluation of PARP and PDL-1 as potential therapeutic targets for women with high-grade neuroendocrine carcinomas of the cervix.
Treatment of neuroendocrine carcinoma of the cervix with a PARP inhibitor based on next generation sequencing.
Carcinoma, Non-Small-Cell Lung
?-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells.
A Small Compound KJ-28d Enhances the Sensitivity of Non-Small Cell Lung Cancer to Radio- and Chemotherapy.
An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer.
APR-246 (PRIMA-1(MET)) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines.
Association of T2285C polymorphism in PARP1 gene coding region with its expression, activity and NSCLC risk along with prognosis.
Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor.
Expression of ERCC1, MSH2 and PARP1 in non-small cell lung cancer and prognostic value in patients treated with platinum-based chemotherapy.
Fluzoparib increases radiation sensitivity of non-small cell lung cancer (NSCLC) cells without BRCA1/2 mutation, a novel PARP1 inhibitor undergoing clinical trials.
Functional Polymorphisms of Base Excision Repair Genes XRCC1 and APEX1 Predict Risk of Radiation Pneumonitis in Patients with Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy.
Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.
Identification of amentoflavone as a potent highly selective PARP-1 inhibitor and its potentiation on carboplatin in human non-small cell lung cancer.
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Inhibition of ELF3 confers synthetic lethality of PARP inhibitor in non-small cell lung cancer.
Inhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.
JASPER: Phase 2 trial of first-line niraparib plus pembrolizumab in patients with advanced non-small cell lung cancer.
Negative prognostic value of high levels of intracellular poly(ADP-ribose) in non-small cell lung cancer.
New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules.
Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors.
Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells.
PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer.
PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer.
PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells.
PARP inhibitor activates the intrinsic pathway of apoptosis in primary lung cancer cells.
PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.
PARP-1 induces EMT in non-small cell lung carcinoma cells via modulating the transcription factors Smad4, p65 and ZEB1.
PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin.
Pelargonium quercetorum Agnew induces apoptosis without PARP or cytokeratin 18 cleavage in non-small cell lung cancer cell lines.
Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non-Small Cell Lung Cancer.
Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity.
Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Radiosynthesis of 3 H- and 14 C-labeled Veliparib.
Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.
Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer.
Replication-dependent ?-H2AX formation is involved in docetaxel-induced apoptosis in NSCLC A549 cells.
Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non-Small Cell Lung Cancer: Methodological Issues.
Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non-Small Cell Lung Cancer.
Synergistic effect of fenretinide and curcumin for treatment of non-small cell lung cancer.
Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells.
Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer.
Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption.
Tankyrase 1 polymorphism associated with an increased risk in developing non-small cell lung cancer in a Chinese population: a proof-of-principle study.
Tankyrase 2 (TNKS2) polymorphism associated with risk in developing non-small cell lung cancer in a Chinese population.
Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling.
WITHDRAWN: An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
A functional polymorphism in the poly(ADP-ribose) polymerase-1 gene is associated with platinum-based chemotherapeutic response and prognosis in epithelial ovarian cancer patients.
A phase I study of the PARP inhibitor niraparib in combination with bevacizumab in platinum-sensitive epithelial ovarian cancer: NSGO AVANOVA1/ENGOT-OV24.
A profile on the FoundationFocus CDxBRCA tests.
A Unique Subset of Epithelial Ovarian Cancers with Platinum Sensitivity and PARP Inhibitor Resistance.
Adenovirus-mediated thymidine kinase gene therapy induces apoptosis in human epithelial ovarian cancer cells and damages PARP-1.
Advances in the Treatment of Ovarian Cancer Using PARP Inhibitors and the Underlying Mechanism of Resistance.
ALDH1A1 contributes to PARP inhibitor resistance via enhancing DNA repair in BRCA2-/- ovarian cancer cells.
Assessment of PARP protein expression in epithelial ovarian cancer by ELISA pharmacodynamic assay and immunohistochemistry.
Association of expression of p53, livin, ERCC1, BRCA1 and PARP1 in epithelial ovarian cancer tissue with drug resistance and prognosis.
BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer.
BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer.
BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide.
BRCA1 Expression by Immunohistochemistry and Prognosis in Ovarian Cancer: A Systematic Review and Meta-Analysis.
Circulating HOXA9-methylated tumour DNA: A novel biomarker of response to poly (ADP-ribose) polymerase inhibition in BRCA-mutated epithelial ovarian cancer.
Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum, and survival.
Combination of triapine, olaparib, and cediranib suppresses progression of BRCA-wild type and PARP inhibitor-resistant epithelial ovarian cancer.
Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines.
Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPis): targeted therapy.
DUETTE: a phase II randomized, multicenter study to investigate the efficacy and tolerability of a second maintenance treatment in patients with platinum-sensitive relapsed epithelial ovarian cancer, who have previously received poly(ADP-ribose) polymerase (PARP) inhibitor maintenance treatment.
Enhanced Efficacy of Combined Therapy with Checkpoint Kinase 1 Inhibitor and Rucaparib Via Regulation of Rad-51 Expression in BRCA Wild-Type Epithelial Ovarian Cancer Cells.
Evaluation of the Efficacy and Safety of PARP Inhibitors in Advanced-Stage Epithelial Ovarian Cancer.
Expression of poly (adenosine diphosphate-ribose) polymerase and p53 in epithelial ovarian cancer and their role in prognosis and disease outcome.
Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene.
N6-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance.
Olaparib and ?-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial.
Olaparib maintenance for first-line treatment of ovarian cancer: will SOLO1 reset the standard of care?
Overcoming Platinum and PARP-Inhibitor Resistance in Ovarian Cancer.
Overcoming resistance to PARP inhibitor in epithelial ovarian cancer, are we ready?
PARP inhibition in epithelial ovarian cancer: high hopes undergo a reality check.
PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality-An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness.
PARP inhibitors alone and in combination with other biological agents in homologous recombination deficient epithelial ovarian cancer: From the basic research to the clinic.
PARP inhibitors and epithelial ovarian cancer: an approach to targeted chemotherapy and personalised medicine.
PARP inhibitors and epithelial ovarian cancer: Molecular mechanisms, clinical development and future prospective.
PARP Inhibitors for Ovarian Cancer: Current Indications, Future Combinations, and Novel Assets in Development to Target DNA Damage Repair.
PARP inhibitors in epithelial ovarian cancer.
PARP Inhibitors in Epithelial Ovarian Cancer: State of Art and Perspectives of Clinical Research.
PARP-1 may be involved in angiogenesis in epithelial ovarian cancer.
PARP1 blockade is synthetically lethal in XRCC1 deficient sporadic epithelial ovarian cancers.
Pharmacological ascorbate induces 'BRCAness' and enhances the effects of Poly(ADP-Ribose) polymerase inhibitors against BRCA1/2 wild-type ovarian cancer.
Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer.
Poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors as maintenance therapy in women with newly diagnosed ovarian cancer: a systematic review and meta-analysis.
Poly (ADP-ribose) polymerase (PARP) as target for the treatment of epithelial ovarian cancer: what to know.
Poly (ADP-ribose) polymerase inhibitors in the management of ovarian cancer.
Poly (ADP-ribose) polymerase inhibitors: on the horizon of tailored and personalized therapies for epithelial ovarian cancer.
Poly (ADP-ribose) polymerase inhibitors: recent advances and future development.
Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer.
Predictive value of ATP7b, BRCA1, BRCA2, PARP1, UIMC1 (RAP80), HOXA9, DAXX, TXN (TRX1), THBS1 (TSP1) and PRR13 (TXR1) genes in patients with epithelial ovarian cancer who received platinum-taxane first-line therapy.
Rationale for combination PARP inhibitor and antiangiogenic treatment in advanced epithelial ovarian cancer: A review.
Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.
Targeted therapy of ovarian cancer including immune check point inhibitor.
Targeting homologous repair deficiency in breast and ovarian cancers: Biological pathways, preclinical and clinical data.
The circuitous path of PARP inhibitor development in epithelial ovarian cancer.
The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer.
The Prognostic and Predictive Role of Somatic BRCA Mutations in Ovarian Cancer: Results from a Multicenter Cohort Study.
The Prognostic Relevance of Poly (ADP-Ribose) Polymerase Expression in Ovarian Cancer Tissue of Wild Type and BRCA-Mutation Carrier Patients.
The Prognostic Value of BRCA1 and PARP Expression in Epithelial Ovarian Carcinoma: Immunohistochemical Detection.
The Prognostic Value of PARP Expression in High-Grade Epithelial Ovarian Cancer.
The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas.
Tolerance and toxicity of the PARP inhibitor olaparib in older women with epithelial ovarian cancer.
Treatment of recurrent ovarian cancer.
Triapine Disrupts CtIP-Mediated Homologous Recombination Repair and Sensitizes Ovarian Cancer Cells to PARP and Topoisomerase Inhibitors.
Tumor BRCA Test for Patients with Epithelial Ovarian Cancer: The Role of Molecular Pathology in the Era of PARP Inhibitor Therapy.
Universal tumor DNA BRCA1/2 testing of ovarian cancer: prescreening PARPi treatment and genetic predisposition.
Update in the use and evaluation of poly (ADP-ribose) polymerase inhibitors in epithelial ovarian cancer: current and pending clinical research.
Using PARP Inhibitors in the Treatment of Patients With Ovarian Cancer.
[Maintenance therapy in patients with advanced epithelial ovarian cancer-impact of anti-angiogenic molecular targeted agents in progress].
Carcinoma, Renal Cell
Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes.
Correction to: Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN.
Heterogeneous nuclear ribonucleoprotein U-like 1 and Poly (ADP-ribose) polymerase 1 are downregulated in renal cell carcinoma and connected with the prognosis.
Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1.
The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity.
The Emerging Role of Poly (ADP-Ribose) Polymerase Inhibitors as Effective Therapeutic Agents in Renal Cell Carcinoma.
Carcinoma, Squamous Cell
A phase I trial adding poly(ADP-ribose) polymerase inhibitor veliparib to induction carboplatin-paclitaxel in patients with head and neck squamous cell carcinoma: Alliance A091101.
Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP.
Cisplatin benefit is predicted by immunohistochemical analysis of DNA repair proteins in squamous cell carcinoma but not adenocarcinoma: theranostic modeling by NSCLC constituent histological subclasses.
Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models.
Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth.
Discovery and Structure-Activity Relationships of Modified Salicylanilides as Cell Permeable Inhibitors of Poly(ADP-ribose) Glycohydrolase (PARG).
Dual disruption of DNA repair and telomere maintenance for the treatment of head and neck cancer.
Effect of poly(ADP-ribose)polymerase and DNA topoisomerase I inhibitors on the p53/p63-dependent survival of carcinoma cells.
Expression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV).
Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP inhibition enhances radiotherapy of SMAD4 deficient human head and neck squamous cell carcinomas in experimental models.
PARP inhibitors: A new era of targeted therapy.
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts.
PARP-1 Val762Ala polymorphism is associated with risk of cervical carcinoma.
PARP1 and CASP3 gene expression in a patient with multiple head and neck squamous cell carcinoma and Parkinson disease.
Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma.
Synergistic Anti-Tumour Effect of Syk Inhibitor and Olaparib in Squamous Cell Carcinoma: Roles of Syk in EGFR Signalling and PARP1 Activation.
The epidermal growth factor receptor is coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rat hepatocytes.
[The effect of tanshinone ?A potentiates the effects of Cisplatin in Fadu cells in vitro through downregulation of survivin].
Carcinoma, Transitional Cell
Influence of pertussis toxin on superficial bladder carcinoma in rats.
Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages.
Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience.
Cardiomegaly
Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging.
AG-690/11026014, a novel PARP-1 inhibitor, protects cardiomyocytes from AngII-induced hypertrophy.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Effect of L-2286, a poly(ADP-ribose)polymerase inhibitor and enalapril on myocardial remodeling and heart failure.
Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure.
Multifarious molecular signaling cascades of cardiac hypertrophy: can the muddy waters be cleared?
Myocardial Gi alpha-protein levels in patients with hypertensive cardiac hypertrophy, ischemic heart disease and cardiogenic shock.
Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy.
PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.
PARP mediates structural alterations in diabetic cardiomyopathy.
PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1.
PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy.
PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy.
Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy.
Possible role of poly(ADP-ribose) polymerase in pathological and physiological cardiac hypertrophy.
Salvianolic acid B protects cardiomyocytes from angiotensin II-induced hypertrophy via inhibition of PARP-1.
SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity.
The orphan receptor NOR1 participates in isoproterenol-induced cardiac hypertrophy by regulating PARP-1.
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA.
The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy.
The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy.
Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.
[The role of G protein, protein kinase C and Na(+)-H+ exchanger in endothelin-1-induced cardiomyocyte hypertrophic responses]
Cardiomyopathies
A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways.
Cardioprotective effects of poly(ADP-ribose) polymerase inhibition.
CircTLK1 modulates sepsis-induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis-mediated mitochondrial DNA damage by sponging miR-17-5p.
Disruption of Nrf2 Synergizes with High Glucose to Cause Heightened Myocardial Oxidative Stress and Severe Cardiomyopathy in Diabetic Mice.
Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption.
PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1? axis.
Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium.
Regulation of kinase cascade activation and heat shock protein expression by poly(ADP-ribose) polymerase inhibition in doxorubicin-induced heart failure.
Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors.
Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications.
The pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity.
Trypanosoma cruzi Induces the PARP1/AP-1 Pathway for Upregulation of Metalloproteinases and Transforming Growth Factor ? in Macrophages: Role in Cardiac Fibroblast Differentiation and Fibrosis in Chagas Disease.
Cardiomyopathy, Dilated
Coupling of adenosine receptors to a pertussis toxin-sensitive G protein in the human heart.
Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate.
Increase of Gi alpha in human hearts with dilated but not ischemic cardiomyopathy.
Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy.
Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium.
Cardiotoxicity
Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Hesperidin promotes lysosomal biogenesis in chronically ethanol-induced cardiotoxicity in rats: A proposed mechanisms of protection.
Influence of PARP-1 inhibition in the cardiotoxicity of the topoisomerase 2 inhibitors doxorubicin and mitoxantrone.
sFRP1 has a biphasic effect on doxorubicin-induced cardiotoxicity in a cellular location-dependent manner in NRCMs and Rats.
The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice.
Cardiovascular Diseases
In vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters.
Mitochondrial-to-nuclear translocation of apoptosis-inducing factor in cardiac myocytes during oxidant stress: potential role of poly(ADP-ribose) polymerase-1.
NAD+ and cardiovascular diseases.
Novel modulators of poly(ADP-ribose) polymerase.
PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases.
PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy.
PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription.
PCB-induced endothelial cell dysfunction: role of poly(ADP-ribose) polymerase.
Pharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: future directions.
Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update.
Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro.
Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death.
Poly(ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure.
Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase.
Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors.
Sp1 Targeted PARP1 Inhibition Protects Cardiomyocytes From Myocardial Ischemia-Reperfusion Injury via Downregulation of Autophagy.
The Role of PARPs in Inflammation-and Metabolic-Related Diseases: Molecular Mechanisms and Beyond.
caspase-3 deficiency
Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death.
Catalepsy
Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism.
Cataract
Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.
Associations of PARP-1 variant rs1136410 with PARP activities, oxidative DNA damage, and the risk of age-related cataract in a Chinese Han population: A two-stage case-control analysis.
Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract.
PARP-1 inhibition influences the oxidative stress response of the human lens.
Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats.
Central Nervous System Diseases
Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease.
PARP-DNA trapping ability of PARP inhibitors jeopardizes astrocyte viability: Implications for CNS disease therapeutics.
Targeting poly(ADP-ribose)polymerase1 in neurological diseases: A promising trove for new pharmacological interventions to enter clinical translation.
The role of poly(ADP-ribose) polymerase-1 in CNS disease.
Central Nervous System Neoplasms
PARP1 expression in pediatric central nervous system tumors.
Cerebellar Ataxia
XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.
Cerebral Hemorrhage
Poly(ADP-ribose) polymerase activation and brain edema formation by hemoglobin after intracerebral hemorrhage in rats.
Cerebral Infarction
Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats.
Evaluation of the poly(ADP-ribose) polymerase gene in human stroke.
MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model.
Neuroprotective effects of KCL-440, a new poly(ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model.
Protection of the brain following cerebral ischemia through the attenuation of PARP-1-induced neurovascular unit damage in rats.
Reversible induction of PARP1 degradation by p53-inducible cis-imidazoline compounds.
[Effect of acupuncture on neurological function, cerebral infarction volume, thrombolysis time window and cerebral cell apoptosis signaling pathway in cerebral infarction rats].
Cerebrovascular Disorders
Neuropilin-1 modulates vascular endothelial growth factor-induced poly(ADP-ribose)-polymerase leading to reduced cerebrovascular apoptosis.
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.
Cervical Intraepithelial Neoplasia
Poly(ADP-Ribose) Polymerase in Cervical Cancer Pathogenesis: Mechanism and Potential Role for PARP Inhibitors.
Chagas Cardiomyopathy
Evidence that myocardial pertussis toxin substrates are uniquely altered in acute murine Chagas' disease in a manner unrelated to myocardial dysfunction.
Chagas Disease
Evidence that myocardial pertussis toxin substrates are uniquely altered in acute murine Chagas' disease in a manner unrelated to myocardial dysfunction.
Inhibition of poly(ADP-ribose) polymerase interferes with Trypanosoma cruzi infection and proliferation of the parasite.
PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance.
Trypanosoma cruzi Induces the PARP1/AP-1 Pathway for Upregulation of Metalloproteinases and Transforming Growth Factor ? in Macrophages: Role in Cardiac Fibroblast Differentiation and Fibrosis in Chagas Disease.
Chickenpox
Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015.
Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019.
Waning vaccine immunity and vaccination responses in children treated for acute lymphoblastic leukemia: A Canadian Immunization Research Network Study.
Cholangiocarcinoma
Binding of tumour necrosis factor-alpha (TNF-alpha) to TNF-RI induces caspase(s)-dependent apoptosis in human cholangiocarcinoma cell lines.
Case Report: BAP1 Mutation and RAD21 Amplification as Predictive Biomarkers to PARP Inhibitor in Metastatic Intrahepatic Cholangiocarcinoma.
Guggulsterone inhibits human cholangiocarcinoma Sk-ChA-1 and Mz-ChA-1 cell growth by inducing caspase-dependent apoptosis and downregulation of survivin and Bcl-2 expression.
Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma.
PARP inhibitor olaparib sensitizes cholangiocarcinoma cells to radiation.
Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas.
The combination of BET and PARP inhibitors is synergistic in models of cholangiocarcinoma.
XIAP Antagonist Embelin Inhibited Proliferation of Cholangiocarcinoma Cells.
Cholera
1,25(OH)2-vitamin D-3 stimulates phospholipase A2 activity via a guanine nucleotide-binding protein in chick myoblasts.
24,25-(OH)2D3 regulates protein kinase C through two distinct phospholipid-dependent mechanisms.
3H-naloxone benzoylhydrazone binding in MOR-1-transfected Chinese hamster ovary cells: evidence for G-protein-dependent antagonist binding.
5-HT1A receptor-mediated activation of G-protein-gated inwardly rectifying K+ current in rat periaqueductal gray neurons.
5-Hydroxytryptamine receptor-mediated phosphoinositide hydrolysis in canine cultured tracheal smooth muscle cells.
A cholera toxin-sensitive G-protein stimulates exocytosis in sea urchin eggs.
A cholera toxin-sensitive guanyl nucleotide binding protein mediates the movement of pituitary luteinizing hormone into a releasable pool: loss of this event is associated with the onset of homologous desensitization to gonadotropin-releasing hormone.
A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in rat Kupffer cells.
A comparative study of the role of adenylate cyclase in the release of adrenocorticotropin from the ovine and rat anterior pituitary.
A developmental role for the heterotrimeric G protein Go alpha in a migratory population of embryonic neurons.
A guanine nucleotide-binding protein mediates 1,25-dihydroxy-vitamin D-3-dependent rapid stimulation of Ca2+ uptake in skeletal muscle.
A membrane-delimited pathway of G-protein regulation of the guard-cell inward K+ channel.
A novel approach to detect toxin-catalyzed ADP-ribosylation in intact cells: its use to study the action of Pasteurella multocida toxin.
A novel cholera toxin-sensitive G-protein (Gc) regulating receptor-mediated phosphoinositide signalling in human pituitary clonal cells.
A novel G protein alpha subunit containing atypical guanine nucleotide-binding domains is differentially expressed in a molluscan nervous system.
A novel G protein alpha subunit in embryo of the ascidian, Halocynthia roretzi.
A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. II. Purification, characterization, and reconstitution.
A novel role for testicular descent; temperature-dependent induction of pertussis toxin-sensitive Gi protein function in postnatal rat Leydig cells.
A pertussis/cholera toxin sensitive G-protein may mediate vasopressin-induced inositol phosphate formation in smooth muscle cell.
A subtype of kappa-opioid receptor mediates inhibition of high-affinity GTPase inherent in Gi1 in guinea pig cerebellar membranes.
AB5 ADP-ribosylating toxins: comparative anatomy and physiology.
AB5 toxins.
Abnormal dopamine sensitivity in some human prolactinomas.
Activation of 5-HT(7) receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels.
Activation of a keratinocyte phospholipase A2 by bradykinin and 4 beta-phorbol 12-myristate 13-acetate. Evidence for a receptor-GTP-binding protein versus a protein-kinase-C mediated mechanism.
Activation of A(3) adenosine receptor induces calcium entry and chloride secretion in A(6) cells.
Activation of adenylate cyclase in rat fat cells promotes an increase in GTP content which controls the enzyme activity.
Activation of cell membrane potassium conductance by mercury in cultured renal epithelioid (MDCK) cells.
Activation of dense human tonsilar B cells. Induction of c-myc gene expression via two distinct signal transduction pathways.
Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate.
Activation of endothelial nitric oxide synthase by proanthocyanidin-rich fraction from Croton celtidifolius (Euphorbiaceae): involvement of extracellular calcium influx in rat thoracic aorta.
Activation of Galpha (i) and subsequent uncoupling of receptor-Galpha(i) signaling by Pasteurella multocida toxin.
Activation of muscarinic m5 receptors inhibits recombinant KCNQ2/KCNQ3 K+ channels expressed in HEK293T cells.
Activation of particulate guanylate cyclase by adrenomedullin in cultured SV-40 transformed cat iris sphincter smooth muscle (SV-CISM-2) cells.
Activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells. Evidence for a novel adenosine receptor.
Activation of PKCbeta(II) and PKCtheta is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation.
Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands.
Activation of the superoxide-generating NADPH oxidase of macrophages by sodium dodecyl sulfate in a soluble cell-free system: evidence for involvement of a G protein.
Additive induction of Egr-1 (zif/268) mRNA expression in neuroblastoma x glioma hybrid NG108-15 cells via cholinergic muscarinic, alpha 2-adrenergic, and bradykinin receptors.
Adenine nucleotides directly stimulate pertussis toxin.
Adenosine diphosphate ribosylation of G proteins by pertussis and cholera toxin in isolated membranes. Different requirements for and effects of guanine nucleotides and Mg2+.
Adenosine inhibits the renal plasma-membrane (Ca2+ + Mg2+)-ATPase through a pathway sensitive to cholera toxin and sphingosine.
Adenosine release and uptake in cerebellar granule neurons both occur via an equilibrative nucleoside carrier that is modulated by G proteins.
Adenylate cyclase activity of v-ras-k transformed rat epithelial thyroid cells.
Adenylate cyclase system in fetal rat keratinizing epidermal cells (FRSK cells) and SV40-transformed human keratinocytes.
Adenylyl cyclase and G-proteins in Phytomonas.
Adenylyl cyclase is involved in desensitization and recovery of ATP-stimulated Cl- secretion in MDCK cells.
Adipocyte plasma membranes contain two Gi subtypes but are devoid of Go.
Adjuvant action of cholera toxin and pertussis toxin in the induction of IgA antibody response to orally administered antigen.
ADP-ribosylation and early transcription regulation by bacteriophage T4.
ADP-ribosylation of bovine S-antigen by cholera toxin.
ADP-ribosylation of membrane proteins by bacterial toxins in the presence of NAD glycohydrolase.
ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.
ADP-ribosyltransferase-specific modification of human neutrophil peptide-1.
Age-dependent changes in transmembrane signalling: identification of G proteins in human lymphocytes and polymorphonuclear leukocytes.
Age-related and testicular regression-induced changes in adenosine 3',5'-monophosphate responses in cultured hamster Sertoli cells.
Age-related changes in beta-adrenergic neuroeffector systems in the human heart.
Age-related changes in G proteins in rat aorta.
Agonist-dependent, cholera toxin-catalyzed ADP-ribosylation of pertussis toxin-sensitive G-proteins following transfection of the human alpha 2-C10 adrenergic receptor into rat 1 fibroblasts. Evidence for the direct interaction of a single receptor with two pertussis toxin-sensitive G-proteins, Gi2 and Gi3.
Albumin endocytosis is regulated by heterotrimeric GTP-binding protein G alpha i-3 in opossum kidney cells.
Alterations in G-proteins in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters.
Alterations of G protein function in cardiac tissues from streptozotocin-induced chronic diabetic rats.
Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi alpha) in spontaneously hypertensive rats.
Altered responses to modulators of guanine nucleotide binding protein activity in endotoxin tolerance.
An arginine residue is the site of receptor-stimulated, cholera toxin-catalysed ADP-ribosylation of pertussis toxin-sensitive G-proteins.
An autocrine motility factor secreted by the Dunning R-3327 rat prostatic adenocarcinoma cell subtype AT2.1.
An examination of the relationship between mu-opioid antinociceptive efficacy and G-protein coupling using pertussis and cholera toxins.
Anaphylatoxins C5a and C3a induce nuclear factor kappaB activation in human peripheral blood monocytes.
Angiotensin II-mediated activation of L-type calcium channels involves phosphatidylinositol hydrolysis-independent activation of protein kinase C in rat portal vein myocytes.
Anti-Inflammatory Effect of Geniposide on Regulating the Functions of Rheumatoid Arthritis Synovial Fibroblasts via Inhibiting Sphingosine-1-Phosphate Receptors1/3 Coupling G?i/G?s Conversion.
Antibodies to the ras gene product inhibit adenylate cyclase and accelerate progesterone-induced cell division in Xenopus laevis oocytes.
Antilipolytic effects of insulin and adenylate cyclase inhibitors on isolated human fat cells.
Antisense oligodeoxynucleotides to GS protein alpha-subunit sequence accelerate differentiation of fibroblasts to adipocytes.
Association of a solubilized prostaglandin E2 receptor from renal medulla with a pertussis toxin-reactive guanine nucleotide regulatory protein.
Astrocytes possess prostaglandin F2 alpha receptors coupled to phospholipase C.
Atrial natriuretic factor effects on cyclic nucleotides in a human renal cell line.
Attenuation of changes in G(i)-proteins and adenylyl cyclase in heart failure by an ACE inhibitor, imidapril.
Autoregulation of acute progesterone and adenosine 3',5'-monophosphate responses to follicle-stimulating hormone (FSH) in porcine granulosa cells: effects of FSH, cholera toxin, forskolin, and pertussis toxin.
B- and T-cell responses to the mycobacterium surface antigen PstS-1 in the respiratory tract and adjacent tissues. Role of adjuvants and routes of immunization.
Bacteria and their toxins tamed for immunotherapy.
Bacterial toxins affect early events of T lymphocyte activation.
Bacterial type AB? enterotoxins--structure, function and mechanism of action.
Beta(2)-Adrenergic activation increases glycogen synthesis in L6 skeletal muscle cells through a signalling pathway independent of cyclic AMP.
beta-adrenergic modulation of maxi-K channels in vascular smooth muscle via Gi through a membrane-delimited pathway.
Beta-adrenoceptor mediated signal transduction in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters.
Bilateral ureteral obstruction alters levels of the G-protein subunits G alpha s and G alpha q/11.
Biochemical demonstration of mu-opioid receptor association with Gsalpha: enhancement following morphine exposure.
Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins.
Biphasic effect of cAMP-elevating agents on ICAM-1 expression stimulated by retinoic acid and interferon gamma.
Biphasic modulation of voltage-dependent currents of retinal cones by cannabinoid CB1 receptor agonist WIN 55212-2.
Blockade of morphine analgesia by both pertussis and cholera toxins in the periaqueductal gray and locus coeruleus.
Blockage of amyloid beta peptide-induced cytosolic free calcium by fullerenol-1, carboxylate C60 in PC12 cells.
Blood mononuclear cell production of TNF-alpha and IL-8: engagement of different signal transduction pathways including the p42 MAP kinase pathway.
Bone Gla protein messenger ribonucleic acid is regulated by both 1,25-dihydroxyvitamin D3 and 3',5'-cyclic adenosine monophosphate in rat osteosarcoma cells.
Botulinum C2 toxin ADP-ribosylates actin.
Bovine pituitary, kidney, uterine and mammary gland extracts contain bovine mammary epithelium growth factors that synergise with IGF-I and fetal calf serum: indication for involvement of GTP-binding proteins.
Bradykinin B2 receptor-mediated proliferation via activation of the Ras/Raf/MEK/MAPK pathway in rat vascular smooth muscle cells.
Bradykinin modulates the electrophysiology of cultured rat sensory neurons through a pertussis toxin-insensitive G protein.
Bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization in canine cultured tracheal epithelial cells.
C5a stimulus-secretion coupling in rat basophilic leukaemia (RBL-2H3) cells transfected with the human C5a receptor is mediated by pertussis and cholera toxin-sensitive G proteins.
Ca2+-stimulated catecholamine release from alpha-toxin-permeabilized PC12 cells: biochemical evidence for exocytosis and its modulation by protein kinase C and G proteins.
Calcium entry stimulated by swelling of Madin-Darby canine kidney cells.
Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons.
Calcium- and G-protein-dependent activation of arachidonic acid release by concanavalin-A-stimulated mouse macrophages.
cAMP antagonizes ERK-dependent antiapoptotic action of insulin.
cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin.
cAMP modulates transepithelial resistance response of LLC-PK1 renal epithelia to tumor necrosis factor.
cAMP-dependent inhibition is dominant in regulating superoxide production in the bone-resorbing osteoclasts.
cAMP-independent dilation of coronary arterioles to adenosine : role of nitric oxide, G proteins, and K(ATP) channels.
Cannabidiol, a novel inverse agonist for GPR12.
Carbohydrate moiety of follitropin receptor is not required for high affinity hormone-binding or for functional coupling between receptor and guanine nucleotide-binding protein in bovine calf testis membranes.
CD3/T-cell receptor coupling to a pertussis and cholera toxin-insensitive G-protein.
Cell-surface expression, progestin binding, and rapid nongenomic signaling of zebrafish membrane progestin receptors alpha and beta in transfected cells.
Cellular Basis for Bimatoprost Effects on Human Conventional Outflow.
Cellular mechanisms of melatonin action.
Changes in cAMP formation in mononuclear leukocytes of heart and renal transplant recipients.
Changes in inositol 1,4,5-trisphosphate mass in agonist-stimulated human neutrophils.
Characterization of a streptococcal antitumor glycoprotein (SAGP).
Characterization of adenosine receptors in brush-border membranes from pig kidney.
Characterization of botulinum C3-catalyzed ADP-ribosylation of rho proteins and identification of mammalian C3-like ADP-ribosyltransferase.
Characterization of bradykinin receptors in canine cultured corneal epithelial cells: pharmacological and functional studies.
Characterization of G-proteins in rat glomeruli.
Characterization of heterotrimeric G-proteins in adult Acanthocheilonema viteae.
Characterization of influenza A virus activation of the human neutrophil.
Characterization of nitric oxide-stimulated ADP-ribosylation of various proteins from the mouse macrophage cell line ANA-1 using sodium nitroprusside and the novel nitric oxide-donating compound diethylamine dinitric oxide.
Characterization of phosphatidylinositol-specific phospholipase C (PI-PLC) from Lilium daviddi pollen.
Characterization of the G protein involved in the muscarinic stimulation of adenylyl cyclase of rat olfactory bulb.
Characterization of the membrane-associated GTPase activity: effects of chemotactic factors and toxins.
Characterization of the plasma membrane bound GTPase from rabbit neutrophils. I. Evidence for an Ni-like protein coupled to the formyl peptide, C5a, and leukotriene B4 chemotaxis receptors.
Characterization of vasopressin-mediated GSH efflux from Hep G2 cells: significance of protein kinase C.
Chemotactic peptide receptor-supported ADP-ribosylation of a pertussis toxin substrate GTP-binding protein by cholera toxin in neutrophil-type HL-60 cells.
Chicken liver contains a large quantity of a G-protein-linked neurotensin receptor.
Chloride channels in cultured human skeletal muscle are regulated by G proteins.
Cholera and pertussis exotoxins protect mice against the lethal Schwartzman reaction and antagonize the effects of lipopolysaccharide on second messenger systems.
Cholera and pertussis toxins amplify prostacyclin synthesis in aortic smooth muscle cells.
Cholera toxin accentuates the antagonism by acetylcholine of higenamine-induced positive chronotropy is isolated right atria of mice.
Cholera toxin ADP-ribosylates the receptor-coupled form of pertussis toxin-sensitive G-proteins.
Cholera toxin and dibutyryl cyclic adenosine 3',5'-monophosphate sensitize gonadotropin-releasing hormone-stimulated inositol phosphate production to inhibition in protein kinase-C (PKC)-depleted cells: evidence for cross-talk between a cholera toxin-sensitive G-protein and PKC.
Cholera toxin and pertussis toxin on opioid- and alpha 2-mediated supraspinal analgesia in mice.
Cholera toxin and pertussis toxin provoke differential effects on luteinizing hormone release, inositol phosphate production, and gonadotropin-releasing hormone (GnRH) receptor binding in the gonadotrope: evidence for multiple guanyl nucleotide binding proteins in GnRH action.
Cholera toxin and pertussis toxin regulate the Fc receptor-mediated phagocytic response of human neutrophils in a manner analogous to regulation by monoclonal antibody 1C2.
Cholera toxin and pertussis toxin stimulate prostaglandin E2 synthesis in a murine macrophage cell line.
Cholera toxin and pertussis toxin substrates and endogenous ADP-ribosyltransferase activity in Drosophila melanogaster.
Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism.
Cholera toxin blocks glucagon-mediated inhibition of the liver plasma membrane (Ca2+-Mg2+)-ATPase.
Cholera toxin but not pertussis toxin inhibits angiotensin II-enhanced contractions in the rat portal vein.
Cholera toxin can ADP-ribosylate Gs as well as Gi in ACTH-unresponsive human adrenocortical cancer.
Cholera toxin directly stimulates pregnenolone generation with increasing Ca2+ efflux in bovine adrenocortical mitochondria.
Cholinergic-induced [3H] noradrenaline release in rat brain cortical slices is mediated via a pertussis toxin sensitive GTP binding protein and involves activation of protein kinase C.
Chronic ethanol promotes the neuronal differentiation of NG108-15 cells independently of toxin-sensitive G-proteins.
Cloning and characterization of a cDNA coding for the alpha-subunit of a stimulatory G protein from Schistosoma mansoni.
Cloning and characterization of a G protein alpha-subunit-encoding gene from the basidiomycete, Coprinus congregatus.
Coexistence of CD14-dependent and independent pathways for stimulation of human monocytes by gram-positive bacteria.
Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C.
Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins.
Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding.
Concanavalin A stimulation of O2 consumption in electropermeabilized neutrophils via a pertussis toxin-insensitive G protein.
Conditional activation of cAMP signal transduction by protein kinase C. The effect of phorbol esters on adenylyl cyclase in permeabilized and intact cells.
Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs.
Could dual G-protein coupling explain [D-Met2]FMRFamide's mixed action in vivo?
Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy.
Coupling of bradykinin receptors to phospholipase C in cultured fibroblasts is mediated by a G-protein.
Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors.
Cross-linking of G-proteins to the prolactin receptor in rat NB2 lymphoma cells.
Cyclic AMP can partially restore platelet-derived growth factor-stimulated prostaglandin E2 biosynthesis, and calcium mobilization in EJ-ras-transformed NIH-3T3 cells.
Cyclic AMP-dependent regulation of the number of [3H]batrachotoxinin benzoate binding sites on rat cardiac myocytes.
Cyclic guanosine monophosphate analogs do not reverse bacterial toxin modulation of lactogen-stimulated NB2 cell mitogenesis.
Cytoplasmic pH change induced by leukotriene B4 in human neutrophils.
Cytoskeletal alterations as a parameter for assessment of toxicity.
D2L, D2S, and D3 dopamine receptors stably transfected into NG108-15 cells couple to a voltage-dependent potassium current via distinct G protein mechanisms.
Decreased potency of glucagon on transformed-induced MDCK cells does not reflect an alteration of adenylate cyclase components.
Deduced amino acid sequence of bovine retinal Go alpha: similarities to other guanine nucleotide-binding proteins.
DeoxyNAD and deoxyADP-ribosylation of proteins.
Desensitization to parathyroid hormone in renal cells from aged rats is associated with alterations in G-protein activity.
Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase.
Detection of G proteins in purified bovine brain myelin.
Developmental changes in the levels of substrates for cholera toxin-catalyzed and pertussis toxin-catalyzed ADP-ribosylation in rat cardiac cell membranes.
Dexamethasone effects on beta-adrenergic receptors and adenylate cyclase regulatory proteins Gs and Gi in ROS 17/2.8 cells.
Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation.
Different endothelin receptor subtypes are involved in phospholipid signalling in the proximal tubule of rat kidney.
Different G proteins are involved in the biphasic response of clonal rat pituitary cells to thyrotropin-releasing hormone.
Different stimulatory opioid effects on intracellular Ca(2+) in SH-SY5Y cells.
Differential alterations in cardiac adrenergic signaling in chronic hypoxia or norepinephrine infusion.
Differential alterations in left and right ventricular G-proteins in congestive heart failure due to myocardial infarction.
Differential cholera-toxin- and pertussis-toxin-catalysed ADP-ribosylation of G-proteins coupled to formyl-peptide and leukotriene B4 receptors.
Differential effects of bacterial toxins on mitogenic actions of sodium fluoride and those of aluminum fluoride in human TE85 osteosarcoma cells.
Differential effects of cholera toxin and pertussis toxin on the c-fos and c-jun mRNA expression in rat C6 glioma cells.
Differential effects of fluoride and a non-hydrolysable GTP analogue on adenylate cyclase and G-proteins in Ceratitis capitata neural tissue.
Differential involvement of hippocampal G-protein subtypes in the memory process of rats.
Differential modulatory effects of cholera toxin and pertussis toxin on pain behavior induced by TNF-alpha, interleukin-1beta and interferon-gamma injected intrathecally.
Differential modulatory roles of cholera toxin and pertussis toxin in the regulation of pain responses induced by excitatory amino acids administered intrathecally in mice.
Differential roles of spinal cholera toxin- and pertussis toxin-sensitive G proteins in nociceptive responses caused by formalin, capsaicin, and substance P in mice.
Differentiation of renal Na(+)-K(+)-ATPase in control and streptozotocin-induced diabetic mice by G-protein acting toxins and phorbol esters.
Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells.
Dissection of lymphocyte function-associated antigen 1-dependent adhesion and signal transduction in human natural killer cells shown by the use of cholera or pertussis toxin.
Distinct mechanisms for Ca2+ entry induced by OKT3 and Ca2+ depletion in Jurkat T cells.
Does interleukin 2 stimulus-response coupling result in generation of intracellular second messengers?
Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells.
Dopamine-induced synaptic depression in the parabrachial nucleus is independent of CTX- and PTX-sensitive G-proteins, PKA and PLC signalling pathways.
Dopaminergic receptors linked to adenylate cyclase in human cerebromicrovascular endothelium.
Dual role of GTP-binding proteins in the control of endothelial prostacyclin.
Effect of adenylate cyclase stimulation on meiotic resumption and cyclic AMP content of zona-free and cumulus-enclosed bovine oocytes in vitro.
Effect of cholera toxin and pertussis toxin on opioid tolerance and dependence in the guinea-pig myenteric plexus.
Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes.
Effect of cholera toxin and pertussis toxin on the growth of A431 cells: kinetics of cyclic AMP and inositol trisphosphate in toxin-treated cells.
Effect of heat shock, [Ca2+]i, and cAMP on inositol trisphosphate in human epidermoid A-431 cells.
Effect of in vivo injection of cholera and pertussis toxin on glucose transport in rat skeletal muscle.
Effect of light on phosphatidate phosphohydrolase activity of retina rod outer segments: the role of transducin.
Effect of nonhydrolyzable guanosine phosphate on IgE-mediated activation of phospholipase C and histamine release from rodent mast cells.
EFFECT OF PEPTIDOGLYCANE OF STAPHYLOCOCCUS AUREUS CELL WALL ON THE MECHANISM OF REGULATION OF CONTRACTILE ACTIVITY OF RAT MYOMETRIUM BY ADENYLATE CYCLASE SYSTEM.
Effect of pertussis and cholera toxins administered supraspinally on CA3 hippocampal neuronal cell death and the blood glucose level induced by kainic acid in mice.
Effect of prenylcysteine analogues on chemoattractant receptor-mediated G protein activation.
Effect of site-directed mutagenic alterations on ADP-ribosyltransferase activity of the A subunit of Escherichia coli heat-labile enterotoxin.
Effect of sodium fluoride on the generation of lipoxygenase products from human polymorphonuclear granulocytes, mononuclear cells and platelets--indication for the involvement of G proteins.
Effects of angiotensin II and angiotensin III on airway epithelial short-circuit current: involvement of pertussis toxin-sensitive G protein.
Effects of calcium on light-activated GTP-binding proteins in squid photoreceptor membranes.
Effects of cholera and pertussis toxins on prolactin stimulation of lactose synthesis and ornithine decarboxylase activity in mouse mammary gland explants.
Effects of chronic receptor blockade on excitation-contraction coupling in rat aortic rings.
Effects of cyclosporine A on cyclic AMP generation and GTP-binding proteins in isolated islets.
Effects of fluoride and cholera and pertussis toxins on sensory transduction in the carotid body.
Effects of follicle stimulating hormone, cholera toxin, pertussis toxin and forskolin on adenosine cyclic 3',5'-monophosphate output by granulosa cells from Booroola ewes with or without the F gene.
Effects of G protein and cGMP on phytochrome-mediated amaranthin synthesis inAmaranthus caudatus seedlings.
Effects of insulin on inositol phosphate production in cultured rat hepatocytes.
Effects of insulin, pertussis toxin and cholera toxin on protein synthesis and diacylglycerol production in 3T3 fibroblasts: evidence for a G-protein mediated activation of phospholipase C in the insulin signal mechanism.
Effects of litter removal on the lipolytic response and the regulatory components of the adenylate cyclase in adipocytes isolated from lactating rats.
Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy.
Effects of Pasteurella haemolytica A1 culture supernatant on mechanisms controlling bovine alveolar macrophage oxygen radical production.
Effects of pertussis and cholera toxin on the interferon-gamma stimulated immunocytochemical staining of ICAM-1 and inositol phosphate formation in a human renal carcinoma cell line.
Effects of pertussis and cholera toxins on alpha-adrenoceptor function in rat tail artery: differences in hypertension.
Effects of protein kinase C activation on cyclic AMP and testosterone production of rat Leydig cells in vitro.
Effects of Ro 5-4864 and PK 11195 in rat duodenum and vas deferens.
Effects of S-nitroso-cysteine on proteins that regulate exocytosis in PC12 cells: inhibitory effects on translocation of synaptophysin and ADP-ribosylation of GTP-binding proteins.
Effects of spinally and supraspinally injected 3-isobutyl-1-methylxanthine, cholera toxin, and pertussis toxin on cold water swimming stress-induced antinociception in the mouse.
Effects of spinally and supraspinally injected 3-isobutyl-1-methylxanthine, cholera toxin, and pertussis toxin on immobilization stress-induced antinociception in the mouse.
Effects of tiazofurin on guanine nucleotide binding regulatory proteins in HL-60 cells.
EGF inhibits secretagogue-induced cAMP production and amylase secretion by Gi proteins in pancreatic acini.
Endogenous ADP-ribosylation of Gs subunit and autonomous regulation of adenylate cyclase.
Endogenous prostaglandin E2 and insulin-like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts.
Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway.
Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature.
Endothelin stimulates platelet-activating factor synthesis by cultured rat Kupffer cells.
Endothelin- and sarafotoxin-induced phosphoinositide hydrolysis in cultured canine tracheal smooth muscle cells.
Endothelin-1 and insulin activate the steady-state voltage dependent R-type Ca2+ channel in aortic smooth muscle cells via a pertussis toxin and cholera toxin sensitive G-protein.
Endothelin-1 receptors on cultured rat articular chondrocytes: regulation by age, growth factors, and cytokines, and effect on cAMP production.
Endothelin-evoked Release of Arachidonic Acid from Mouse Astrocytes in Primary Culture.
Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction.
Endotoxins in cholera and pertussis toxins interfere with in vivo responses to these agents in the albino rabbit eye.
Enhanced expression of inhibitory guanine nucleotide regulatory protein in spontaneously hypertensive rats. Relationship to adenylate cyclase inhibition.
Enhanced negative inotropic effect of an adenosine A1-receptor agonist in rat left atria in hypothyroidism.
Enhancement in beta-adrenergic responsiveness of adenylate cyclase in rat liver during regeneration after carbon tetrachloride administration.
Enhancement of parathyroid hormone-responsive renal cortical adenylate cyclase activity by a cytosol protein activator from rat reticulocytes.
Entamoeba invadens contains the components of a classical adrenergic signaling system.
Epidermal growth factor activation of rat parotid gland adenylate cyclase and mediation by a GTP-binding regulatory protein.
Epoxyeicosatrienoic acid stimulates ADP-ribosylation of a 52 kDa protein in rat liver cytosol.
Estrogen uncouples beta-adrenergic receptor from the stimulatory guanine nucleotide-binding protein in female rat hypothalamus.
ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species.
Evaluation of activation of G proteins in response to thyroid stimulating hormone in thyroid gland cells from euthyroid and hyperthyroid cats.
Evidence for expression of a Ras-like and a stage specific GTP binding homologous protein by Plasmodium falciparum.
Evidence for G-Protein Regulation of Inward K+ Channel Current in Guard Cells of Fava Bean.
Evidence for guanosine triphosphate--binding proteins in Trypanosoma cruzi.
Evidence for the implication of phosphoinositol signal transduction in mu-opioid inhibition of DNA synthesis.
Evidence for the involvement of a pertussis toxin-insensitive G-protein in egg activation of the frog, Xenopus laevis.
Evidence for tight coupling of Gi protein-mediated lysophosphatidic acid receptor to stimulated cytokine production in ovarian cancer cell.
Evidence for two different stimulatory adenylate cyclase coupling mechanisms in rat renal papilla.
Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms.
Evidence that Arg-295, Glu-378, and Glu-380 are active-site residues of the ADP-ribosyltransferase activity of iota toxin.
Evidence that the action of calcitonin on rat osteoclasts is mediated by two G proteins acting via separate post-receptor pathways.
Evidence that the appressorial development in barley powdery mildew is controlled by MAP kinase activity in conjunction with the cAMP pathway.
Evidence that thyrotropin-releasing hormone-induced increases in GTPase activity and phosphoinositide metabolism in GH3 cells are mediated by a guanine nucleotide-binding protein other than Gs or Gi.
Evidence that v-Src-induced phospholipase D activity is mediated by a G protein.
Expression of Bordetella pertussis Antigens Fused to Different Vectors and Their Effectiveness as Vaccines.
Extracellular ATP elevates cytoplasmatic free Ca2+ in HeLa cells by the interaction with a 5'-nucleotide receptor.
Extracellular matrix proteins are potent agonists of human smooth muscle cell migration.
Facilitative actions of the protein kinase-C effector system on hormonally stimulated adenosine 3',5'-monophosphate production by swine luteal cells.
Fluoride activation of neutrophils: similarities to formylmethionyl-leucyl-phenylalanine.
Fluoride produces endothelium-dependent relaxation and endothelium-independent contraction in coronary artery.
FMS*Calciumfluor increases alkaline phosphatase expression during osteogenesis in vitro of tibia-derived rat osteoblasts by activation of G alpha 0/G alpha i proteins.
Follicle-stimulating hormone receptor-mediated uptake of 45Ca2+ by cultured rat Sertoli cells does not require activation of cholera toxin- or pertussis toxin-sensitive guanine nucleotide binding proteins or adenylate cyclase.
Functional and molecular characterization of CCK receptors in the rat pancreatic acinar cell line AR 4-2J.
Functional and molecular characterization of VIP receptor--effector system in rat developing immunocompetent cells: G protein involvement.
Functional characterization of the Na(+)-H+ exchanger in rat mast cells: crosstalks between different kinase pathways.
Functional compartments in rat mast cells for cAMP and calcium on histamine release.
Functional interactions between colony-stimulating factors and the insulin family hormones for human myeloid leukemic cells.
Functional maturation of human T lymphocytes is accompanied by changes in the G-protein pattern.
Functional modification by cholera-toxin-catalyzed ADP-ribosylation of a guanine-nucleotide-binding regulatory protein serving as the substrate of pertussis toxin.
Functional reconstitution of detergent-solubilized bovine calf testis luteinizing hormone/chorionic gonadotropin receptor into phospholipid vesicles.
Functional specialization of fibronectin-binding beta 1-integrins in T lymphocyte migration.
Further Elucidation of a Pertussis Toxin-Sensitive Transmembrane Signaling Mechanism Involved in Central alpha(2)-Adrenoceptor Activation in the Rat.
G protein activation inhibits amiloride-blockable highly selective sodium channels in A6 cells.
G protein coupling of antigen receptor-stimulated polyphosphoinositide hydrolysis in B cells.
G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A2A receptors.
G protein coupling to M1 and M3 muscarinic receptors in sublingual glands.
G protein function in the ischaemic myocardium.
G protein in stimulation of PI hydrolysis by CCK in isolated rat pancreatic acinar cells.
G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide.
G proteins in Aplysia: biochemical characterization and regional and subcellular distribution.
G proteins regulate calcium channels in the luminal membranes of the rabbit nephron.
G proteins subserve relaxations mediated by adenosine receptors in human coronary artery.
G-protein activation decreases isoflurane inhibition of N-type Ba2+ currents.
G-protein activators induce a potassium conductance in murine macrophages.
G-protein from Medicago sativa: functional association to photoreceptors.
G-protein involvement in muscarinic receptor-stimulation of inositol phosphates in longitudinal smooth muscle from the small intestine of the guinea-pig.
G-protein mediation of cannabinoid-induced phospholipase activation.
G-protein regulation of an L-type calcium channel current in canine jejunal circular smooth muscle.
G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells.
G-protein-mediated regulation of the insulin-responsive glucose transporter in isolated cardiac myocytes.
G-proteins and egg activation.
G-proteins coupled to phosphoinositide hydrolysis in the cochlear and vestibular sensory epithelia of the rat are insensitive to cholera and pertussis toxins.
G-proteins modulate amiloride-sensitive sodium channels.
G-proteins modulate prolactin- and interleukin-2-stimulated mitogenesis in rat Nb2 lymphoma cells.
G?14 subunit-mediated inhibition of voltage-gated Ca2+ and K+ channels via neurokinin-1 receptors in rat celiac-superior mesenteric ganglion neurons.
G?s proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-?v?3 and CD44-CD44 interactions.
Galectin-3 stimulates uptake of extracellular Ca2+ in human Jurkat T-cells.
Gastrin stimulation of histamine synthesis in enterochromaffin-like cells from rabbit fundic mucosa.
Gbetagamma dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells.
Generation of inositol phosphates in bitter taste transduction.
Genes coding for proteins in central nervous system myelin.
Gi protein-mediated translocation of serine/threonine phosphatase to the plasma membrane and apoptosis of ovarian cancer cell in response to gonadotropin-releasing hormone antagonist cetrorelix.
Gialpha3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event.
Gonadotropin-releasing hormone (GnRH)-receptor coupling to inositol phosphate and prolactin production in GH3 cells stably transfected with rat GnRH receptor complementary deoxyribonucleic acid.
Granulocyte-macrophage colony stimulating factor activates proteoglycan, type II collagen, and cAMP production by rat articular chondrocytes through specific binding sites.
Growth factors, signaling pathways, and the regulation of proliferation and differentiation in BC3H1 muscle cells. I. A pertussis toxin-sensitive pathway is involved.
GTP-binding protein couples with metabotropic glutamate receptor in bovine retinal on-bipolar cell.
GTP-binding protein G alpha Z: its down-regulation by dexamethasone and its credentials as a mediator of antigen-induced responses in RBL-2H3 cells.
GTP-binding proteins and adenylate cyclase activity in v-Ki-ras transformed NIH/3T3 fibroblast cells.
GTP-binding proteins associated with serotonin-activated adenylate cyclase in Fasciola hepatica.
GTP-binding proteins in luminal and basolateral membranes from pars convoluta and pars recta of rabbit kidney proximal tubule.
Guanine nucleotide binding protein involvement in early steps of phytochrome-regulated gene expression.
Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors.
Guanine nucleotide binding proteins mediate the chemotactic signal of transforming growth factor-beta 1 in rat IL-2 activated natural killer cells.
Guanine nucleotide-binding protein regulation of microsomal phospholipase D activity of canine cerebral cortex.
Guanine nucleotide-binding proteins involved in transmembrane signaling.
Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.
Guanine-induced inhibition of renal Na(+)-ATPase activity: Evidence for the involvement of the Gi protein-coupled receptor.
Guanosine triphosphate can directly regulate cortisol production by activating Ca(2+)-messenger systems in bovine adrenal fasciculata cells.
Gz, a guanine nucleotide-binding protein with unique biochemical properties.
Heat shock increases cytosolic free Ca2+ concentration via Na(+)-Ca2+ exchange in human epidermoid A 431 cells.
Heterologous regulations of cAMP responses in pregnant rat myometrium. Evolution from a stimulatory to an inhibitory prostaglandin E2 and prostacyclin effect.
Heterotrimeric G-protein candidates for Ge in the ACTH secretory pathway.
Histamine H1 receptors in C6 glial cells are coupled to calcium-dependent potassium channels via release of calcium from internal stores.
HIV-1 Tat protein mimicry of chemokines.
Homotypic lysosome fusion in macrophages: analysis using an in vitro assay.
Hormonal regulation of rat renal proximal tubule brush-border membrane ionic permeability.
HSP-72 synthesis is promoted by increase in [Ca2+]i or activation of G proteins but not pHi or cAMP.
Human glycolipid transfer protein (GLTP) expression modulates cell shape.
Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation.
Human pancreatic tumor growth hormone (GH) - releasing factor and cyclic adenosine 3',5'- monophosphate evoke GH release from anterior pituitary cells: the effects of pertussis toxin, cholera toxin, forskolin, and cycloheximide.
Hyperosmolar solution effects in guinea pig airways. III. Studies on the identity of epithelium-derived relaxing factor in isolated perfused trachea using pharmacological agents.
Idazoxan down-regulates beta-adrenoceptors on C6 glioma cells in vitro.
Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go.
Identification of a botulinum C3-like enzyme in bovine brain that catalyzes ADP-ribosylation of GTP-binding proteins.
Identification of a region in the S1 subunit of pertussis toxin that is required for enzymatic activity and that contributes to the formation of a neutralizing antigenic determinant.
Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes.
Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3.
Identification of G-proteins in rat parotid gland plasma membranes and granule membranes: presence of distinct components in granule membranes.
Identification of heterotrimeric and low molecular weight GTP-binding proteins in rabbit skeletal muscle longitudinal sarcoplasmic reticulum.
Identification of Novel Competing ?(2)AR Phospho-Extracellular Signal Regulated Kinase 1/2 Signaling Pathways in Human Trabecular Meshwork Cells.
Identification of novel phytocannabinoids from Ganoderma by label-free dynamic mass redistribution assay.
Identification of the pertussis and cholera toxin substrates in normal and N-ras transformed NIH3T3 fibroblasts and an assessment of their involvement in bombesin-stimulation of inositol phospholipid metabolism.
IL-8 induces the locomotion of human IL-2-activated natural killer cells. Involvement of a guanine nucleotide binding (Go) protein.
Immunochemical detection of GTP-binding protein in cephalopod photoreceptors by anti-peptide antibodies.
Impaired G-proteins and cyclic nucleotide phosphodiesterase activity in T-lymphocytes from patients with sarcoidosis.
Importance of CCL2-CCR2A/2B signaling for monocyte migration into spheroids of breast cancer-derived fibroblasts.
In vitro effects of 17 beta-oestradiol on the sensitivity of receptors coupled to adenylate cyclase on striatal neurons in primary culture.
In vivo evidence that lithium inactivates Gi modulation of adenylate cyclase in brain.
Increase in Gs and cyclic AMP generation in HIT cells. Evidence that the 45-kDa alpha-subunit of Gs has greater functional activity than the 52-kDa alpha-subunit.
Increased intracellular cyclic adenosine monophosphate inhibits T lymphocyte-mediated cytolysis by two distinct mechanisms.
Induction of promiscuous G protein coupling of the follicle-stimulating hormone (FSH) receptor: a novel mechanism for transducing pleiotropic actions of FSH isoforms.
Influence of bacterial toxins and forskolin upon vasopressin-induced inositol phosphate accumulation in WRK 1 cells.
Influence of pertussis toxin on parathyroid hormone stimulated cyclic AMP production and phosphate transport in opossum kidney cells.
Inhibition and activation of interleukin 2 synthesis by direct modification of guanosine triphosphate-binding proteins.
Inhibition of hormonally induced inositol trisphosphate production in Transfected GH4C1 cells: A novel role for the D5 subtype of the dopamine receptor.
Inhibition of protein phosphatase 2A (PP2A) mimics suckling-induced sensitization of mammotropes: involvement of a pertussis toxin (PTX) sensitive G-protein and the adenylate cyclase (AC).
Inhibition of renal Na+-ATPase activity by inosine is mediated by A1 receptor-induced inhibition of the cAMP signaling pathway.
Inhibition of swine microglial cell phagocytosis of Cryptococcus neoformans by femtomolar concentrations of morphine.
Inhibition of thyrotropin-stimulated adenosine 3',5'-monophosphate formation in rat thyroid cells by an adenosine analog. Evidence that the inhibition is mediated by the putative inhibitory guanine nucleotide regulatory protein.
Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states.
Inositol phosphate formation and chloride current responses induced by acetylcholine and serotonin through GTP-binding proteins in Xenopus oocyte after injection of rat brain messenger RNA.
Insulin activates GTP binding to a 40 kDa protein in fat cells.
Insulin stimulates a novel GTPase activity in human platelets.
Insulin stimulation of cyclic AMP phosphodiesterase is independent from the G-protein pathways involved in adenylate cyclase regulation.
Insulin-like growth factors enhance phagocytosis by human neutrophils in vitro.
Insulinotropic toxins as molecular probes for analysis of glucagon-likepeptide-1 receptor-mediated signal transduction in pancreatic beta-cells.
Interactions of alpha-melanotropin and agouti on B16 melanoma cells: evidence for inverse agonism of agouti.
Interleukin (IL)-8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C.
Interleukin-1 beta inhibition of insulin release in rat pancreatic islets: possible involvement of G-proteins in the signal transduction pathway.
Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4).
Interleukin-1beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP.
Intracellular coupling of prostaglandin inhibition of acid secretion in isolated rabbit gastric parietal cells.
Intracellular regulation of enzyme secretion from rat osteoclasts and evidence for a functional role in bone resorption.
Involvement of a GTP-binding protein in stimulating action of angiotensin II on calcium channels in vascular smooth muscle cells.
Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown.
Involvement of an inhibitory G-protein in the signal transduction pathway of maturation-inducing hormone (17 alpha,20 beta-dihydroxy-4-pregnen-3-one) action in rainbow trout (Oncorhynchus mykiss) oocytes.
Involvement of G proteins in the effect of insulin-like growth factor I on gonadotropin-induced rat granulosa cell differentiation.
Involvement of heterotrimeric G proteins in phagocytosis and recycling from the phagosomal compartment.
Involvement of Rho and p38 MAPK in endothelin-1-induced expression of PGHS-2 mRNA in osteoblast-like cells.
Involvement of signal transducing GTP-binding proteins in renal artery alpha 1-adrenoceptor mediated smooth muscle contraction.
Involvement of signaling pathways in bovine sperm motility, and effect of ergot alkaloids.
Ionomycin induces prostaglandin E2 formation in murine osteoblastic MC3T3-E1 cells via mechanisms independent of its ionophoric nature.
Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase.
Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides.
Isoproterenol enhances a calcium-independent potassium current in mouse anterior pituitary tumor cells.
K-ras transformation greatly increases the toxin-dependent ADP-ribosylation of GTP binding proteins in thyroid cells. Involvement of an inhibitor of the ADP-ribosylation reaction.
Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus.
L-channel modulation by alpha-1 adrenoceptor activation in neonatal rat ventricular cells: intracellular mechanisms.
Label-free detection and identification of protein ligands captured by receptors in a polymerized planar lipid bilayer using MALDI-TOF MS.
Ligand binding and functional characterization of muscarinic acetylcholine receptors on the TE671/RD human cell line.
Ligand-induced formation of the leukotriene B4 receptor-G protein complex of human polymorphonuclear leukocytes.
Light activation of phosphatidylethanolamine N-methyltransferase in rod outer segments and its modulation by association states of transducin.
Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins.
Light-dependent GTP-binding proteins in squid photoreceptors.
Lithium administration modulates platelet Gi in humans.
Localization of several G-protein subunits to the apical and basolateral membranes of cortical tubular cells from the rat kidney.
Low-density lipoprotein (LDL) binds to a G-protein coupled receptor in human platelets. Evidence that the proaggregatory effect induced by LDL is modulated by down-regulation of binding sites and desensitization of its mediated signaling.
Luteinizing hormone secretion is enhanced by pertussis toxin, cholera toxin, and forskolin. Evidence for the involvement of the cyclic AMP-generating system.
Luteinizing hormone/choriogonadotropin-dependent, cholera toxin-catalyzed adenosine 5'-diphosphate (ADP)-ribosylation of the long and short forms of Gs alpha and pertussis toxin-catalyzed ADP-ribosylation of Gi alpha*.
Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gels.
M2 muscarinic receptor-mediated inhibition of the Ca2+ current in rat magnocellular cholinergic basal forebrain neurones.
mADP-RTs: versatile virulence factors from bacterial pathogens of plants and mammals.
Mast cell activation by pedicellarial toxin of sea urchin, Toxopneustes pileolus.
Mastoparan, a wasp venom peptide, stimulates release of prolactin from cultured rat anterior pituitary cells.
Mastoparan-induced apoptosis of cultured cerebellar granule neurons is initiated by calcium release from intracellular stores.
Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate.
Mechanism of action of GTP in the induction of Ca2+ release from hepatic microsomes.
Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta.
Mechanism of macrophage injury following traumatic hemorrhagic shock: through PTX-sensitive G-protein-mediated signal transduction pathway.
Mechanism(s) of activation of secretory phospholipase A(2)s in mouse keratinocytes.
Mechanisms of bradykinin-mediated Ca(2+) signalling in canine cultured corneal epithelial cells.
Mechanisms of nonopsonic phagocytosis of Pseudomonas aeruginosa.
Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells.
Melatonin receptors in benign prostate epithelial cells: evidence for the involvement of cholera and pertussis toxins-sensitive G proteins in their signal transduction pathways.
Membrane-bound form of ADP-ribosyl cyclase in rat cortical astrocytes in culture.
Metallothionein mediates leukocyte chemotaxis.
Mg(++)-induced endothelial cell migration: substratum selectivity and receptor-involvement.
Microsomal and cytosolic fractions of guinea pig hepatocytes contain 100-kilodalton GTP-binding proteins reactive with antisera against alpha subunits of stimulatory and inhibitory heterotrimeric GTP-binding proteins.
Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate.
Mitigation of beta 1- and/or beta 2-adrenoceptor function in human heart failure.
Mitoxantrone induces nonimmunological histamine release from rat mast cells.
Modification of biological responses to interleukin-1 by agents that perturb signal transduction pathways.
Modification of the amounts of G proteins and of the activity of adenylyl cyclase in human benign thyroid tumours.
Modification of the function of pertussis toxin substrate GTP-binding protein by cholera toxin-catalyzed ADP-ribosylation.
Modulation by 1,25(OH)2-vitamin D3 of the adenylyl cyclase/cyclic AMP pathway in rat and chick myoblasts.
Modulation of brain Na+ channels by a G-protein-coupled pathway.
Modulation of Ca(2+)-channel currents by protein kinase C in adult rat sympathetic neurons.
Modulation of Ca2+ currents by various G protein-coupled receptors in sympathetic neurons of male rat pelvic ganglia.
Modulation of CD4 Th cell differentiation by ganglioside GD1a in vitro.
Modulation of meiotic arrest in mouse oocytes by guanyl nucleotides and modifiers of G-proteins.
Modulation of prolactin-stimulated Nb2 lymphoma cell mitogenesis by cholera toxin and pertussis toxin.
Modulation of protein kinase C by adenosine: involvement of adenosine A1 receptor-pertussis toxin sensitive nucleotide binding protein system.
Modulation of sperm acrosomal exocytosis by guanyl nucleotides and G-protein-modifier agents.
Modulation of tumor necrosis factor-alpha cytotoxicity in L929 cells by bacterial toxins, hydrocortisone and inhibitors of arachidonic acid metabolism.
Molecular characterization of a G protein alpha-subunit-encoding gene from Mucor circinelloides.
Molecular model of the G protein alpha subunit based on the crystal structure of the HRAS protein.
Mono(adenosine diphosphate ribosyl) transferase in Xenopus tissues. Direct demonstration by a zymographic localization in sodium dodecyl sulfate--polyacrylamide gels.
Monoclonal antibodies against the enzymatic subunit of both pertussis and cholera toxins.
Morphine stimulates phagocytosis of Mycobacterium tuberculosis by human microglial cells: involvement of a G protein-coupled opiate receptor.
Mucosal immunization with a genetically engineered pertussis toxin S1 fragment-cholera toxin subunit B chimeric protein.
Mucosal vaccination approach against mosquito-borne Japanese encephalitis virus.
Multiple effects of phorbol ester on secretory activity in rabbit gastric glands and parietal cells.
Multiple isoforms of ADP-ribosylated G-like proteins from mammalian thyroid membranes.
Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells.
Multiple trimeric G-proteins on the trans-Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation.
Multiplicative interaction between intrathecally and intracerebroventricularly administered morphine for antinociception in the mouse: effects of spinally and supraspinally injected 3-isobutyl-1-methylxanthine, cholera toxin, and pertussis toxin.
Muscarine modulation by a G-protein alpha-subunit of delayed rectifier K+ current in rat ventromedial hypothalamic neurones.
Muscarinic receptor activation modulates Ca2+ channels in rat intracardiac neurons via a PTX- and voltage-sensitive pathway.
Muscarinic receptor subclassification and G-proteins: significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics.
Muscarinic receptor-linked elevation of cAMP in SH-SY5Y neuroblastoma cells is mediated by Ca2+ and protein kinase C.
Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes.
Muscarinic receptor-mediated hydrolysis of phosphatidylinositols in human neuroblastoma (SH-SY5Y) cells is sensitive to pertussis toxin.
Myelin basic protein binds GTP at a single site in the N-terminus.
Myeloid cell proliferation stimulated by Steel factor is pertussis toxin sensitive and enhanced by cholera toxin.
NADP+ enhances cholera and pertussis toxin-catalyzed ADP-ribosylation of membrane proteins.
Neuropeptide FF receptors couple to a cholera toxin-sensitive G-protein in rat dorsal raphe neurones.
Neurotensin modulates the electrical activity of frog pituitary melanotropes via activation of a G-protein-coupled receptor pharmacologically related to both the NTS1 and nts2 receptors of mammals.
Neutrophil activation by surface bound IgG: pertussis toxin insensitive activation.
Neutrophil thrombospondin receptors are linked to GTP-binding proteins.
Nod factors activate both heterotrimeric and monomeric G-proteins in Vigna unguiculata (L.) Walp.
Nongenomic aldosterone effects: the cell membrane as a specific target of mineralocorticoid action.
Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells.
Nootropic drug modulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons.
Noradrenaline release enhanced by cholera toxin and pertussis toxin in rat cerebral cortical slices.
Noradrenergic potentiation of cerebellar Purkinje cell responses to GABA: cyclic AMP as intracellular intermediary.
Novel mechanism for non-genomic action of 17 beta-oestradiol on kainate-induced currents in isolated rat CA1 hippocampal neurones.
Novel molecular biology approaches to acellular vaccines.
Nuclear membrane R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells.
Occurrence and biochemical characterization of GTP-binding proteins in Candida albicans.
On the mechanism of action of dexamethasone in a rat mast cell line (RBL-2H3 cells). Evidence for altered coupling of receptors and G-proteins.
Ontogenesis of alpha 2-adrenoceptor coupling with GTP-binding proteins in the rat telencephalon.
Oocyte adenylyl cyclase contains Ni, yet the guanine nucleotide-dependent inhibition by progesterone is not sensitive to pertussis toxin.
Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (Gi) in membranes of neuroblastoma x glioma hybrid cells.
Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells.
Opposing influences of dexamethasone and retinoic acid on adenylate cyclase activity in ROS 17/2.8 cells.
Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o).
OxLDL induces mitogen-activated protein kinase activation mediated via PI3-kinase/Akt in vascular smooth muscle cells.
OxLDL upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38 mitogen-activated protein kinase.
P2-purinoceptor-stimulated phosphoinositide turnover in chick myotubes. Calcium mobilization and the role of guanyl nucleotide-binding proteins.
PAF effects on transmembrane signaling pathways in rat Kupffer cells.
Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells.
Parathyroid hormone/adenylate cyclase coupling in vascular smooth muscle cells.
PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders.
Participation of pertussis toxin-sensitive GTP-binding regulatory proteins in the suppression of baroreceptor reflex by neurotensin in the rat.
Peptide mapping studies of the pertussis toxin substrate in human neutrophils, platelets and erythrocytes.
Peptidergic modulation of G-protein coupled cyclic-AMP accumulation in the rat caudate nucleus.
Pertussis and cholera toxin ADP-ribosylation in Dictyostelium discoideum membranes.
Pertussis but not cholera toxin inhibits the stimulated increase in actin association with the cytoskeleton in rabbit neutrophils: role of the "G proteins" in stimulus-response coupling.
Pertussis toxin actions on the pituitary-derived 235-1 clone: effects of PGE1, cholera toxin, and forskolin on cyclic AMP metabolism and prolactin release.
Pertussis toxin B-subunit-induced Ca2(+)-fluxes in Jurkat human lymphoma cells: the action of long-term pre-treatment with cholera and pertussis holotoxins.
Pertussis toxin inhibits intracellular pH changes in human neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine.
Pertussis toxin pretreatment abolishes the inhibitory effect of riluzole and carbachol on D-[3H]aspartate release from cultured cerebellar granule cells.
Pertussis toxin substrate is a guanosine 5'-[beta-thio]diphosphate-, N-ethylmaleimide-, Mg2+- and temperature-sensitive GTP-binding protein.
Pertussis toxin treatment blocks the inhibition of somatostatin and increases the stimulation by forskolin of cyclic AMP accumulation and adrenocorticotropin secretion from mouse anterior pituitary tumor cells.
Pertussis toxin-mediated ADP-ribosylation of rabbit luteal Gi uncouples enkephalin inhibition of adenylyl cyclase.
Pertussis toxin-sensitive G protein modulates the ability of histamine to stimulate cAMP production in the chick pineal gland.
Pertussis toxin-sensitive G proteins mediate carbachol-induced REM sleep and respiratory depression.
Pertussis toxin-sensitive Galphai protein and ERK-dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts.
Pertussis toxin-sensitive GTP-binding proteins regulate activation-induced apoptotic cell death of human natural killer cells.
Pertussis-toxin insensitive enkephalin inhibition of adenylyl cyclase in lacrimal acinar cells.
PGE2 increases the tetrodotoxin-resistant Nav1.9 sodium current in mouse DRG neurons via G-proteins.
Phosphatidic acid and lysophosphatidic acid induce haptotactic migration of human monocytes.
Phosphoinositide metabolism in a polyoma-BK-virus-transformed pancreatic islet cell line: evidence for constitutively activated phospholipase C.
Photosensitivity of the isolated pigment epithelium and arachidonic acid metabolism: preliminary results.
Physical and functional association of follitropin receptors with cholera toxin-sensitive guanine nucleotide-binding protein.
Platelet activating factor activates MAPK and increases in intracellular calcium via independent pathways in B lymphocytes.
Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils.
Platelet cytosolic 44-kDa protein is a substrate of cholera toxin-induced ADP-ribosylation and is not recognized by antisera against the alpha subunit of the stimulatory guanine nucleotide-binding regulatory protein.
Platelet-activating factor (PAF) induces a contraction of isolated smooth muscle cells from guinea pig ileum: intracellular pathway involved.
Platelet-activating factor (PAF) stimulates phosphatidylinositol hydrolysis in human peripheral blood mononuclear leukocytes.
Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway.
Platelet-activating factor stimulates transcription of the heparin-binding epidermal growth factor-like growth factor in monocytes. Correlation with an increased kappa B binding activity.
Pneumocystis carinii infection alters GTP-binding proteins in the lung.
Possible involvement of GTP-binding proteins in 1 alpha,25-dihydroxyvitamin D3 induction of tissue transglutaminase in mouse peritoneal macrophages.
Post-receptor defect accounts for phosphorylase hypersensitivity in cultured diabetic cardiomyocytes.
Potentiation by cholera toxin of bradykinin-induced inositol phosphate production in the osteoblast-like cell line MC3T3-E1.
Potentiation by higenamine of the aconitine-induced positive chronotropic effect in isolated right atria of mice: the effects of cholera toxin, forskolin and pertussis toxin.
Potentiation of the glycine-activated Cl- current by ethanol in cultured mouse spinal neurons.
Preferential involvement of Go and Gz proteins in mediating rat natural killer cell lysis of allogeneic and tumor target cells.
Pregnancy enhances G protein activation and nitric oxide release from uterine arteries.
Presynaptic inhibition by concanavalin A: are alpha-latrotoxin receptors involved in action potential-dependent transmitter release?
Pretreatment with cholera or pertussis toxin differentially modulates morphine- and beta-endorphin-induced antinociception in the mouse formalin test.
Priming effects of granulocyte-macrophage colony-stimulating factor are coupled to cholera toxin-sensitive guanine nucleotide binding protein in human T lymphocytes.
Probable occurrence of toxin-susceptible G proteins in the nematode Caenorhabditis elegans.
Properties of 1-methyladenine receptors in starfish oocyte membranes: involvement of pertussis toxin-sensitive GTP-binding protein in the receptor-mediated signal transduction.
Properties of a novel GTP-binding protein which is associated with soluble phosphoinositides-specific phospholipase C.
Properties of muscarinic-stimulated adenylate cyclase activity in rat olfactory bulb.
Propionic acid-induced calcium mobilization in human neutrophils.
Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons.
Prostaglandin E2 can bimodally inhibit and stimulate the epididymal adipocyte adenylyl cyclase activity.
Prostaglandin E2 contracts vascular smooth muscle and inhibits potassium currents in vascular smooth muscle cells of rat tail artery.
Prostaglandin F(2alpha) receptor-dependent regulation of prostaglandin transport.
Protein intake affects levels of G-protein subunits G alpha i2, G alpha i3, and G beta in rat glomerular membranes.
Protein kinase C potentiates isoproterenol-mediated cyclic AMP production without modifying the homologous desensitization process in J774 cells.
Protein kinase C regulation of the adenylyl cyclase system in rat prostatic epithelium.
Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to Aroclor 1242, a mixture of polychlorinated biphenyls.
Purification of a histamine H3 receptor negatively coupled to phosphoinositide turnover in the human gastric cell line HGT1.
Purine metabolites suppress proliferation of human NK cells through a lineage-specific purine receptor.
Quartz crystal microbalance investigation of the interaction of bacterial toxins with ganglioside containing solid supported membranes.
Rapid high mass resolution mass spectrometry using matrix-assisted ionization.
Rapid membrane responses to dihydrotestosterone are sex dependent in growth plate chondrocytes.
Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1.
Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene.
Regional characterization of G-protein subunits in glomeruli, cortices and medullas of the rat kidney.
Regulation by GTP of a Ca(2+)-activated K+ channel in the apical membrane of rabbit cortical collecting duct cells.
Regulation of bradykinin receptor level by cholera toxin, pertussis toxin and forskolin in cultured human fibroblasts.
Regulation of bradykinin-induced Ins(1,4,5)P3 formation by protein kinase C in human fibroblasts.
Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea.
Regulation of follicle-stimulating hormone binding to receptors on bovine calf testis membranes by cholera toxin-sensitive guanine nucleotide binding protein.
Regulation of G proteins by adenosine receptor agonist in coronary artery.
Regulation of G(q/11)alpha by the gonadotropin-releasing hormone receptor.
Regulation of kinesin expression and type IV collagenase secretion in invasive human prostate PC-3 tumor sublines.
Regulation of lens cyclic nucleotide metabolism by Ca2+ plus calmodulin.
Regulation of melanoma cell adhesion stabilization to fibronectin.
Regulation of mouse placental lactogen secretion by G proteins before midpregnancy.
Regulation of renal cortical Na-HCO3 cotransporter. II. Role of G proteins.
Regulation of superoxide anion generation in bovine alveolar macrophages by bacterial lipopolysaccharide, serum proteins, and modulators of signal transduction.
Regulation of the CHAPS-solubilized muscarinic receptors by an inhibitory GTP binding protein (Gi) in the brain of neonatal and adult rats.
Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by mannose 6-phosphate, insulin like growth factors and epidermal growth factor.
Regulation of thrombin-induced endothelial cell activation by bacterial toxins.
Regulatory factors that determine growth and phenotype of normal human melanocytes.
Relationship between the self-incompatibility and cAMP level in Lilium longiflorum.
Release of guanosine triphosphate binding protein alpha subunits from mouse myocardial membranes: basic properties and their alterations in acute murine Chagas disease.
Requirements for Langerhans' cell depletion following in vitro exposure of murine skin to ultraviolet-B.
Resistance of the insulinotropic action of alpha-D-glucose and beta-L-glucose pentaacetates to cholera and pertussis toxins.
Role of a pertussis toxin sensitive G-protein in mediating the effects of phorbol esters on receptor activated cyclic AMP accumulation in Jurkat cells.
Role of a pertussis toxin substrate in the control of lectin-induced cap formation in human neutrophils.
Role of a protein regulating guanine nucleotide binding in phosphoinositide breakdown and calcium mobilization by bradykinin in neuroblastoma X glioma hybrid NG108-15 cells: effects of pertussis toxin and cholera toxin on receptor-mediated signal transduction.
Role of G-proteins in ciliary process adenylyl cyclase responses of the albino rabbit eye.
Role of guanine nucleotide regulatory proteins and inositol phosphates in the hormone induced mobilization of hepatocyte calcium.
Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells.
Sarafotoxin-induced calcium mobilization in cultured dog tracheal smooth muscle cells.
Second-messenger regulation of receptor association with clathrin-coated pits: a novel and selective mechanism in the control of CD4 endocytosis.
Secretoneurin and chemoattractant receptor interactions.
Selective activation of a chimeric Gi1/Gs G protein alpha subunit by the human IP prostanoid receptor: analysis using agonist stimulation of high affinity GTPase activity and [35S]guanosine-5'-O-(3-thio)triphosphate binding.
Selective loss of pertussis toxin-sensitive G-proteins from the plasma membrane after antibody-induced internalization of T-cell surface molecules.
Selective modulation by guanine nucleotides of the high affinity subset of plasma membrane receptors for leukotriene B4 on human polymorphonuclear leukocytes.
Sequence and structural links between distant ADP-ribosyltransferase families.
Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors.
Serotonin receptor-mediated activation of adenylate cyclase in the neuroblastoma NCB.20: a novel 5-hydroxytryptamine receptor.
Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway.
Signal transduction alterations in GH(1)2C1 rat pituitary tumour cells following treatment with 5-azacytidine.
Signal transduction in Coprinus congregatus: evidence for the involvement of G proteins in blue light photomorphogenesis.
Signal transduction modulation by lithium: cell culture, cerebral microdialysis and human studies.
Signal transduction of a tissue interaction during embryonic heart development.
Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling.
Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.
Single-cell analysis of macrophage chemotactic protein-1-regulated cytosolic Ca2+ increase in human adherent monocytes.
Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity.
Solubilization from rat pancreatic plasma membranes of a cholecystokinin (CCK) agonist-receptor complex interacting with guanine nucleotide regulatory proteins coexisting in the same macromolecular system.
Solubilization of the vasopressin receptor from rat liver plasma membranes. Evidence for a receptor X GTP-binding protein complex.
Somatocrinin stimulates adenylate cyclase-Ns regulatory subunit in a GH3 cell-line: comparison with VIP.
Somatostatin acts through G-proteins on dopaminergic adenylate cyclase in the caudate-putamen of the rat.
Somatostatin inhibits bombesin-stimulated Gi-protein via its own receptor in rabbit colonic smooth muscle cells.
Somatostatin inhibits cAMP-mediated cholinergic transmission in the myenteric plexus.
Somatostatin modulation of adenosine receptor coupled G-protein subunits in the caudate nucleus of the rat.
Spermatozoa contain a guanine nucleotide-binding protein ADP-ribosylated by pertussis toxin.
Stimulation of beta(3)-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes.
Stimulation of cyclic adenosine 3',5'-monophosphate production enhances hypothalamic luteinizing hormone-releasing hormone release without increasing prostaglandin E2 synthesis: studies in prepubertal female rats.
Stimulation of DNA synthesis in Jurkat cells by synergistic action between adenine and guanine nucleotides.
Stimulation of generation of inositol phosphates by carbamoylcholine and its inhibition by phorbol esters and iodide in dog thyroid cells.
Stimulation of glycogenolysis by three locust adipokinetic hormones involves Gs and cAMP.
Stimulation of high-affinity GTPase activity and cholera toxin-catalysed [32P]ADP-ribosylation of Gi by lysophosphatidic acid (LPA) in wild-type and alpha 2C10 adrenoceptor-transfected Rat 1 fibroblasts.
Stimulation of luteinizing hormone (LH) release and phospholipid breakdown by guanosine triphosphate in permeabilized pituitary gonadotropes: antagonist action suggests association of a G protein and gonadotropin-releasing hormone receptor.
Stimulation of luteinizing hormone release by sodium fluoride is independent of protein kinase-C activity and unaffected by desensitization to gonadotropin-releasing hormone.
Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone in human granulosa-luteal cells.
Stimulation of mitogen-activated protein kinase by thyrotropin in primary cultured human thyroid follicles.
Stimulation of mono-ADP ribosylation in rat liver plasma membranes after long-term alcohol intake.
Stimulatory and inhibitory guanine-nucleotide-binding regulatory protein involvement in stimulation of arachidonic-acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea-pig alveolar macrophages. Differential receptor/G-protein interaction assessed by pertussis and cholera toxins.
Stimulatory effect of guanine nucleotides on prostaglandin E1 binding to murine renal outer medulla.
Streptococcal glycoprotein-induced tumour cell growth inhibition involves the modulation of a pertussis toxin-sensitive G protein.
Stromal Cell-Derived Factor 1 Increases Tetrodotoxin-Resistant Sodium Currents Nav1.8 and Nav1.9 in Rat Dorsal Root Ganglion Neurons via Different Mechanisms.
Structural and functional relationships of guanosine triphosphate binding proteins.
Structural characterization of pertussis toxin A subunit.
Structural evidence for the evolution of pyrogenic toxin superantigens.
Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells.
Study of the activation mechanism of adriamycin on rat mast cells.
Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein.
Subcellular distribution and membrane association of human neutrophil substrates for ADP-ribosylation by pertussis toxin and cholera toxin.
Substance P stimulation of polyphosphoinositide hydrolysis in rat anterior pituitary membranes involves a GTP-dependent mechanism.
Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells.
Subtypes of Guanine-Nucleotide-Binding Regulatory Proteins at the Locus coeruleus Involved in Fentanyl-Induced Muscular Rigidity in the Rat.
Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity.
Suramin has adjuvant properties and promotes expansion of antigen-specific Th1 and Th2 cells in vivo.
Sustained activation of phospholipase D via adenosine A3 receptors is associated with enhancement of antigen- and Ca(2+)-ionophore-induced secretion in a rat mast cell line.
T cell activation via the T cell receptor: a comparison between WT31 (defining alpha/beta TcR)-induced and anti-CD3-induced activation of human T lymphocytes.
Terminal serotonin autoreceptor function in the rat hippocampus is not modified by pertussis and cholera toxins.
The adenylyl cyclase-cyclic AMP system modulates morphological and functional development of hypothalamic beta-endorphin neurons in culture.
The antineoplastic drug vinorelbine activates non-immunological histamine release from rat mast cells.
The bombesin receptor is coupled to a guanine nucleotide-binding protein which is insensitive to pertussis and cholera toxins.
The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells.
The cloned human 5-HT1E receptor couples to inhibition and activation of adenylyl cyclase via two distinct pathways in transfected BS-C-1 cells.
The comparative analysis of proenkephalin mRNA expression induced by cholera toxin and pertussis toxin in primary cultured rat cortical astrocytes.
The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding.
The effect of PGF2 alpha on parathyroid hormone-stimulated cyclic AMP production in mouse osteoblastic cell, MC3T3E1.
The effect of vasoactive intestinal polypeptide (VIP) on forskolin stimulated adenylate cyclase in the caudate-putamen of the rat.
The effects of cholera toxin, pertussis toxin, sodium fluoride and alpha-interferon on prostaglandin production by the guinea-pig endometrium.
The effects of endothelins on the secretion of prolactin, luteinizing hormone, and follicle-stimulating hormone are mediated by different guanine nucleotide-binding proteins.
The effects of extracellular calcium and epinephrine on cytosolic-free calcium in single rat adipocytes.
The effects of pertussis toxin and cholera toxin on mitogen-induced interleukin-2 production: evidence for G protein involvement in signal transduction.
The effects of phorbol 12-myristate 13-acetate, cholera toxin, prostaglandin E2 and norepinephrine on inducible nitric oxide synthase activation induced by lipopolysaccharide in C6 cells.
The GTP-binding regulatory proteins, Gs and G(i), are altered in erythrocyte membranes of patients with ischemic heart disease resulting from coronary atherosclerosis.
The heterotrimeric GTP-binding protein, GS, modulates the Cl- conductance of rat parotid acinar secretory granules.
The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.
The lymphoma transmembrane glycoprotein GP85 (CD44) is a novel guanine nucleotide-binding protein which regulates GP85 (CD44)-ankyrin interaction.
The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase.
The regulation of adenylate cyclase in liver membranes of lean and obese mice.
The role of G proteins in thromospondin-1-induced vascular smooth muscle cell migration.
The role of G-proteins in the activation of human leukocytes by particulate stimuli to produce reactive oxygen metabolites.
The role of G-proteins in the mitogenesis of rat lactogen-dependent and lactogen-independent Nb2 lymphoma cells.
The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation.
The signaling pathway in photoresponses that may be mediated by visual pigments in erythrophores of Nile tilapia.
The stimulatory and inhibitory effects of dopamine on prolactin secretion involve different G-proteins.
The thyrotropin receptor is not involved in the activation of p42/p44 mitogen-activated protein kinases by thyrotropin preparations in Chinese hamster ovary cells expressing the human thyrotropin receptor.
The uterotonic action of the aqueous extract of Bridelia atroviridis in the rat.
Theileria parva sporozoite entry into bovine lymphocytes involves both parasite and host cell signal transduction processes.
Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets.
Thrombospondin promotes chemotaxis and haptotaxis of human peripheral blood monocytes.
Thromboxane A2 agonist modulation of excitatory synaptic transmission in the rat hippocampal slice.
Thromboxane A2 mediates the stimulation of inositol 1,4,5-trisphosphate production and intracellular calcium mobilization by bradykinin in neonatal rat ventricular cardiomyocytes.
Thyrotropin effect on the availability of Ni regulatory protein in FRTL-5 rat thyroid cells to ADP-ribosylation by pertussis toxin.
Thyrotropin-releasing hormone activates a Ca2+-dependent polyphosphoinositide phosphodiesterase in permeable GH3 cells. GTP gamma S potentiation by a cholera and pertussis toxin-insensitive mechanism.
Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to the guanosine triphosphate-binding proteins Gq and G11.
Thyrotropin-releasing hormone stimulation of polyphosphoinositide hydrolysis in GH3 cell membranes is GTP dependent but insensitive to cholera or pertussis toxin.
TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae.
TNF-alpha stimulates increased plasma membrane guanine nucleotide binding protein activity in polymorphonuclear leukocytes.
Toxins-useful biochemical tools for leukocyte research.
Transcriptional regulation of Na/K-ATPase by corticosteroids, glycyrrhetinic acid and second messenger pathways in rat kidney epithelial cells.
Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways.
Treatment of intact striatal neurones with cholera toxin or 8-bromoadenosine 3',5'-(cyclic)phosphate decreases the ability of pertussis toxin to ADP-ribosylate the alpha-subunits of inhibitory and other guanine-nucleotide-binding regulatory proteins, Gi and Go. Evidence for two distinct mechanisms.
Trimeric G proteins regulate the cytosol-induced redistribution of Golgi enzymes into the endoplasmic reticulum.
Trypanosoma cruzi: infection of cultured human endothelial cells alters inositol phosphate synthesis.
Tumor necrosis factor alpha 'primes' the platelet-activating factor-induced superoxide production by human neutrophils: possible involvement of G proteins.
Tumor necrosis factor alpha modulates parathyroid hormone action in UMR-106-01 osteoblastic cells.
Two different G-proteins mediate neuropeptide Y and bradykinin-stimulated phospholipid breakdown in cultured rat sensory neurons.
Two distinct light regulated G-proteins in octopus photoreceptors.
Two distinct pathways of platelet-activating factor-induced hydrolysis of phosphoinositides in primary cultures of rat Kupffer cells.
TXA2 agonists inhibit high-voltage-activated calcium channels in rat hippocampal CA1 neurons.
Vanadate changes Ca2+ influx pathway properties in human red blood cells.
Variations in guanine-binding proteins (Gs, Gi) in cultured bovine adrenal cells. Consequences on the effects of phorbol ester and angiotensin II on adrenocorticotropin-induced and cholera-toxin-induced cAMP production.
Vascular insulin/insulin-like growth factor-1 resistance in female obese Zucker rats.
Vasoactive intestinal polypeptide modulates GABAA receptor function through activation of cyclic AMP.
Vasopressin and amastatin induce V(1)-receptor-mediated suppression of excitatory transmission in the rat parabrachial nucleus.
Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA.
Voltage-dependent calcium channels and Gi regulatory protein mediate the human sperm acrosomal exocytosis induced by N-acetylglucosaminyl/mannosyl neoglycoproteins.
Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion.
[Abnormalities in the beta-adrenergic receptor-adenylate cyclase system in the ventricular myocardium of spontaneously hypertensive rats]
[Effect of bacterial toxins on the mitogen-induced increase of the Ca2+ concentration in the cytoplasm of rat thymocytes. The role of N proteins]
[Identification and purification of GTP-binding regulatory proteins from plasma membranes of swine heart]
[Involvement of G proteins between receptors and KCa channels in the regulation of airway tone by the autonomic nervous system]
[Isoproterenol, denopamine, and atenolol-induced alterations in beta-adrenergic receptor-adenylate cyclase system of rat myocardium]
[Role of a guanine nucleotide regulatory protein in exocrine pancreatic secretion--effects of cholera toxin and pertussis toxin on cholecystokinin action]
[The effect of G protein regulator on pollen germination and [Ca2+]i variation in Pyrus serotina Rehd. pollen.]
[The role of different subtypes of G protein in the secretory function of macrophages stimulated by activated complement following severe burn injury]
Chondrosarcoma
BL-038, a Benzofuran Derivative, Induces Cell Apoptosis in Human Chondrosarcoma Cells through Reactive Oxygen Species/Mitochondrial Dysfunction and the Caspases Dependent Pathway.
Current questions in bone sarcomas.
Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status.
Recombinant human PDCD5 sensitizes chondrosarcomas to cisplatin chemotherapy in vitro and in vivo.
Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation.
Vacuolar Protein Sorting 4B (VPS4B) Regulates Apoptosis of Chondrocytes via p38 Mitogen-Activated Protein Kinases (MAPK) in Osteoarthritis.
Chordoma
Blockage of Stat3 With CDDO-Me Inhibits Tumor Cell Growth in Chordoma.
Combination of PARP inhibitor and temozolomide to suppress chordoma progression.
Defective homologous recombination DNA repair as therapeutic target in advanced chordoma.
Histone deacetylase inhibitors as potential therapeutic approaches for chordoma: An immunohistochemical and functional analysis.
Identification of therapeutic targets in chordoma through comprehensive genomic and transcriptomic analyses.
PARP1 is a novel independent prognostic factor for the poor prognosis of chordoma.
Choriocarcinoma
Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome.
PARP expression in germ cell tumours.
Ciliopathies
Analysis from the perspective of cilia: the protective effect of PARP inhibitors on visual function during light-induced damage.
Cleft Palate
Alteration of DNA Damage Response Causes Cleft Palate.
Cockayne Syndrome
Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.
Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.
Linking DNA damage, NAD(+)/SIRT1, and aging.
PARP and CSB modulate the processing of transcription-mediated DNA strand breaks.
PARP10 deficiency manifests by severe developmental delay and DNA repair defect.
Poly(ADP-ribose) polymerase 1 (PARP1) promotes oxidative stress-induced association of Cockayne syndrome group B protein with chromatin.
Poly(ADP-ribosyl)ation accelerates DNA repair in a pathway dependent on Cockayne syndrome B protein.
Coinfection
Activation of caspases in pig kidney cells infected with wild-type and CrmA/SPI-2 mutants of cowpox and rabbitpox viruses.
C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells.
Lethal infection by Bordetella pertussis mutants in the infant mouse model.
Colitis
5-Aminoisoquinolinone reduces colon injury by experimental colitis.
Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis.
Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment.
Beyond dna repair,the immunological role of parp-1 and its siblings.
Effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, in a mouse model of acute pancreatitis induced by cerulein.
GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat.
Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis.
Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis.
PARP inhibition reduces acute colonic inflammation in rats.
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors.
Poly(ADP-ribose) polymerase inhibitors.
Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications.
Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation.
Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications.
Poly(ADP-ribose) polymerase-1 inhibitor ameliorates dextran sulfate sodium-induced colitis in mice by regulating the balance of Th17/Treg cells and inhibiting the NF-?B signaling pathway.
Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies.
The Peri-appendiceal Red Patch in Ulcerative Colitis: Review of the University of Chicago Experience.
Transcriptional reprogramming and resistance to colonic mucosal injury in Poly(ADP-ribose) polymerase 1 (PARP1)-deficient mice.
Treatment with PARP-1 inhibitors, GPI 15427 or GPI 16539, ameliorates intestinal damage in rat models of colitis and shock.
Upregulation of Salmonella-induced IL-6 production in Caco-2 cells by PJ-34, PARP-1 inhibitor: involvement of PI3K, p38 MAPK, ERK, JNK, and NF-kappaB.
Colitis, Ulcerative
DNA Repair Protein Expression and Oxidative/Nitrosative Stress in Ulcerative Colitis and Sporadic Colorectal Cancer.
PARP inhibition reduces acute colonic inflammation in rats.
Colonic Neoplasms
2'-Hydroxycinnamaldehyde induces apoptosis through HSF1-mediated BAG3 expression.
8-Oxo-7,8-dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients.
?-Lapachone Inhibits Lung Metastasis of Colorectal Cancer by Inducing Apoptosis of CT26 Cells.
Absence of stimulation of poly(ADP-ribose) polymerase activity in patients predisposed to colon cancer.
Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis.
Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis.
Adenosine induces apoptosis through TNFR1/RIPK1/P38 axis in colon cancer cells.
Anticancer effect of fermented Insampaedok-san in human colon cancer cells: a pilot study.
Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer.
Benzo[b]tryptanthrin inhibits MDR1, topoisomerase activity, and reverses adriamycin resistance in breast cancer cells.
Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation.
Capsaicin Mediates Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells via Stabilizing and Activating p53.
CD44-shRNA recombinant adenovirus inhibits cell proliferation, invasion, and migration, and promotes apoptosis in HCT116 colon cancer cells.
Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.
Chemical characterization and biological activity data for a novel indirubin derivative, LDD-1819.
Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol.
Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1.
Correction: Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1- immunotherapy in colon cancer.
Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis.
Detection of poly(ADP-ribose) polymerase cleavage in response to treatment with topoisomerase I inhibitors: a potential surrogate end point to assess treatment effectiveness.
Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling.
Dimeric 3,5-bis(benzylidene)-4-piperidones: A novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties.
DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study.
Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways.
Epigallocatechin-3-Gallate Induces Apoptosis as a TRAIL Sensitizer via Activation of Caspase 8 and Death Receptor 5 in Human Colon Cancer Cells.
ERCC1, PARP-1, and AQP1 as predictive biomarkers in colon cancer patients receiving adjuvant chemotherapy.
Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer.
Fish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo.
Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells.
Functional characterization of peroxisome proliferator-activated receptor-?/? expression in colon cancer.
Human colon cancer HT-29 cell death responses to doxorubicin and Morus Alba leaves flavonoid extract.
Identification of PARP-1 in cancer stem cells of gastrointestinal cancers: A preliminary study.
Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways.
Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway.
Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan.
Inhibition of arginine ADP-ribosyltransferase 1 reduces the expression of poly(ADP-ribose) polymerase-1 in colon carcinoma.
Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma.
Ipatasertib sensitizes colon cancer cells to TRAIL-induced apoptosis through ROS-mediated caspase activation.
Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization.
Melatonin potentiates the antiproliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways.
Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad.
MSH3 expression does not influence the sensitivity of colon cancer HCT116 cell line to oxaliplatin and poly(ADP-ribose) polymerase (PARP) inhibitor as monotherapy or in combination.
Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1.
Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation.
Periostin induces chemoresistance in colon cancer cells through activation of the PI3K/Akt/survivin pathway.
Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice.
Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study.
Prodigiosin-induced apoptosis in human colon cancer cells.
Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice.
SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS-STING Activation and Chemotherapeutic Sensitivity in Colon Cancer.
Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan.
Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer.
Terpenes from essential oils and hydrolate of Teucrium alopecurus triggered apoptotic events dependent on caspases activation and PARP cleavage in human colon cancer cells through decreased protein expressions.
The PARP inhibitor ABT-888 synergizes irinotecan treatment of colon cancer cell lines.
The pro-apoptotic effect of quercetin in cancer cell lines requires ER?-dependent signals.
The steroidal Na+/K+ ATPase inhibitor 3-[(R)-3-pyrrolidinyl]oxime derivative (3-R-POD) induces potent pro-apoptotic responses in colonic tumor cells.
The use of olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks.
TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death.
Transgelin interacts with PARP1 in human colon cancer cells.
Tumor necrosis factor-alpha induces apoptosis associated with poly(ADP-ribose) polymerase cleavage in HT-29 colon cancer cells.
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.
Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells.
Vitexin-2-O-xyloside, raphasatin and (-)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells.
Colorectal Neoplasms
A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.
A phase 2 study of the PARP inhibitor veliparib plus temozolomide in patients with heavily pretreated metastatic colorectal cancer.
A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin.
Alkannin-Induced Oxidative DNA Damage Synergizes With PARP Inhibition to Cause Cancer-Specific Cytotoxicity.
Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells.
ASO Author Reflections: ATMIN Altering the WNT Signaling Pathway via PARP1 in MSI-High Colorectal Cancer.
ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib.
ATMIN Suppresses Metastasis by Altering the WNT-Signaling Pathway via PARP1 in MSI-High Colorectal Cancer.
BRD4 Inhibitor AZD5153 Suppresses the Proliferation of Colorectal Cancer Cells and Sensitizes the Anticancer Effect of PARP Inhibitor.
Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk.
Colorectal cancers differ in respect of PARP-1 protein expression.
Combination Therapy with Radiation and PARP Inhibition Enhances Responsiveness to Anti-PD-1 Therapy in Colorectal Tumor Models.
Combined olaparib and oxaliplatin inhibits tumor proliferation and induces G2/M arrest and ?-H2AX foci formation in colorectal cancer.
Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51.
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
DNA Repair Protein Expression and Oxidative/Nitrosative Stress in Ulcerative Colitis and Sporadic Colorectal Cancer.
DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study.
Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer.
Effect of acidic environment and p53 on apoptosis induction by hyperthermia.
Effect of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in patients with colorectal cancer.
Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement.
From PARP1 to TNKS2 Inhibition: A Structure-Based Approach.
Glycogen synthase kinase 3? inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer.
HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer.
Identification of anticancer drugs to radiosensitise BRAF-wild-type and mutant colorectal cancer.
Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma.
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.
In Vitro and In Vivo Enhancement of Chemoradiation Using the Oral PARP Inhibitor ABT-888 in Colorectal Cancer Cells.
Luteolin induces apoptosis in BE colorectal cancer cells by downregulating calpain, UHRF1, and DNMT1 expressions.
MACROD2 deletions cause impaired PARP1 activity and chromosome instability in colorectal cancer.
MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.
Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity.
MRE11 Deficiency Increases Sensitivity to Poly(ADP-ribose) Polymerase Inhibition in Microsatellite Unstable Colorectal Cancers.
MSH3 Mediates Sensitization of Colorectal Cancer Cells to Cisplatin, Oxaliplatin, and a Poly(ADP-ribose) Polymerase Inhibitor.
New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells.
Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells.
Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration.
Novel mutations of the PARP-1 gene associated with colorectal cancer in the Saudi population.
Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis.
p53 Enhances Artemisia annua L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells.
PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.
PARP-Targeted Auger Therapy in p53 Mutant Colon Cancer Xenograft Mouse Models.
PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of cell proliferation, is involved in colorectal cancer development.
Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells.
Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells.
Poly(ADP-Ribose) Polymerase Inhibition Sensitizes Colorectal Cancer-Initiating Cells to Chemotherapy.
Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.
Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a Northeast Chinese population.
Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling.
Quantitative Proteomics Identifies DNA Repair as a Novel Biological Function for Hepatocyte Nuclear Factor 4? in Colorectal Cancer Cells.
Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate.
Reactive Oxygen Species and p53 Mediated Activation of p38 and Caspases is Critically Involved in Kaempferol Induced Apoptosis in Colorectal Cancer Cells.
Sensitization of colorectal cancer to irinotecan therapy by PARP inhibitor rucaparib.
Sildenafil inhibits the growth of human colorectal cancer in vitro and in vivo.
Temozolomide: Mechanisms of Action, Repair and Resistance.
The depletion of securin enhances butein-induced apoptosis and tumor inhibition in human colorectal cancer.
The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3'Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort.
The synthetic lethal killing of RAD54B-deficient colorectal cancer cells by PARP1 inhibition is enhanced with SOD1 inhibition.
Treatment with the PARP inhibitor, niraparib, sensitizes colorectal cancer cell lines to irinotecan regardless of MSI/MSS status.
Two DNA repair gene polymorphisms on the risk of gastrointestinal cancers: a meta-analysis.
Ursolic Acid Induces Apoptosis in Colorectal Cancer Cells Partially via Upregulation of MicroRNA-4500 and Inhibition of JAK2/STAT3 Phosphorylation.
XRCC2 promotes colorectal cancer cell growth, regulates cell cycle progression, and apoptosis.
XRCC2 rs3218536 polymorphism decreases the sensitivity of colorectal cancer cells to poly(ADP-ribose) polymerase 1 inhibitor.
[Inhibitory effect of 5-aminoisoquinolinone on PARP activity in colon carcinoma cell line HT-29]
[PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study].
Colorectal Neoplasms, Hereditary Nonpolyposis
Temozolomide: Mechanisms of Action, Repair and Resistance.
The Importance of Distinguishing Sporadic Cancers from Those Related to Cancer Predisposing Germline Mutations.
[Molecular Targeted Therapies for Hereditary Cancer Syndrome].
Communicable Diseases
Pertussis toxin: transition state analysis for ADP-ribosylation of G-protein peptide alphai3C20.
Congenital Abnormalities
Association of sperm morphology and the sperm deformity index (SDI) with poly (ADP-ribose) polymerase (PARP) cleavage inhibition.
Calcium Alleviates Fluoride-Induced Bone Damage by Inhibiting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction.
Contracture
Effect of pertussis toxin on normorphine-dependence and on acute inhibitory effects of normorphine and clonidine in guinea-pig isolated ileum.
Effects of cannabinoids on tension induced by acetylcholine and choline in slow skeletal muscle fibers of the frog.
Coronary Artery Disease
DNA Damage, an Innocent Bystander in Atrial Fibrillation and Other Cardiovascular Diseases?
Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.
Poly(ADP-Ribose) Polymerase Activity and Coronary Artery Disease in Type 2 Diabetes Mellitus: An Observational and Bidirectional Mendelian Randomization Study.
Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, angiographically verified coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus.
Coronary Occlusion
Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.
Coronavirus Infections
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity.
Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention.
Cough
Antibody responses to individual Bordetella pertussis fimbrial antigens Fim2 or Fim3 following immunisation with five component acellular pertussis vaccine or disease.
Comparative efficacy of acellular pertussis vaccines: an analysis of recent trials.
Determination of pertactin IgG antibodies for the diagnosis of pertussis.
Measures to control an outbreak of pertussis in a neonatal intermediate care nursery after exposure to a healthcare worker.
Parents as source of pertussis transmission in hospitalized young infants.
Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling.
Prevalence and incidence of adult pertussis in an urban population.
Responses to Bordetella pertussis mutant strains and to vaccination in the coughing rat model of pertussis.
[Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. II. Occurence and level of B. pertussis antigens in children with suspected whooping cough]
COVID-19
Chemotherapy directly followed by poly(ADP-ribose) polymerase inhibition as an alternative to surgery in patients with BRCA-mutated ovarian cancer: a potential management strategy in the era of coronavirus disease 2019.
Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity.
Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway.
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide.
Role of Poly(ADP-ribose) Polymerase (PARP1) in Viral Infection and its Implication in SARS-CoV-2 Pathogenesis.
The potential association between PARP14 and SARS-CoV-2 infection (COVID-19).
Thirty-day suicidal thoughts and behaviours in the Spanish adult general population during the first wave of the Spain COVID-19 pandemic.
Cowpox
Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis.
IL-3 withdrawal activates a CrmA-insensitive poly(ADP-ribose) polymerase cleavage enzyme in factor-dependent myeloid progenitor cells.
Craniocerebral Trauma
A novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury: An immunohistochemical and behavioral study.
Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors.
Poly(adenosine diphosphate-ribose) polymerase expression in human traumatic brain injury.
Crohn Disease
Distinct production of autoantibodies to nuclear components in ulcerative colitis and in Crohn's disease.
Role of microRNA-223 in the regulation of poly(ADP-ribose) polymerase in pediatric patients with Crohn's disease.
Cryptorchidism
Heat stress reduces poly(ADPR)polymerase expression in rat testis.
Over expression of LDOC1 and PARP1, two pro-apoptotic genes, in a patient with cryptorchidism and DiGeorge anomaly.
Cystadenoma
Rapamycin-resistant PARP1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis (LAM).
Cystadenoma, Serous
Poly(adenosine diphosphate-ribose) polymerase expression in serous ovarian carcinoma: correlation with p53, MIB-1, and outcome.
Cystic Fibrosis
Children with cystic fibrosis produce an immune response against exoenzyme S, a type III cytotoxin of Pseudomonas aeruginosa.
Distinct fates of monocytes and T cells directly activated by Pseudomonas aeruginosa exoenzyme S.
G-protein regulation of outwardly rectified epithelial chloride channels incorporated into planar bilayer membranes.
Pseudomonas aeruginosa exoenzyme S induces transcriptional expression of proinflammatory cytokines and chemokines.
Role of exoenzyme S in chronic Pseudomonas aeruginosa lung infections.
The role of protein kinase C in alpha-adrenergic regulation of NaCl(K) cotransport in human airway epithelial cells.
TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins.
Cystitis
Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation.
Protein nitration, PARP activation and NAD+ depletion may play a critical role in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis in the rat.
Cysts
In vitro formation and expansion of cysts derived from human renal cortex epithelial cells.
Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.
cytidine deaminase deficiency
Cytidine deaminase deficiency impairs sister chromatid disjunction by decreasing PARP-1 activity.
Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.
Dehydration
Effects of long-term dehydration on oxidative stress, apoptotic markers and neuropeptides in the gastric mucosa of the dromedary camel.
Photo-Protective Mechanisms and the Role of Poly (ADP-Ribose) Polymerase Activity in a Facultative CAM Plant Exposed to Long-Term Water Deprivation.
Physiological, biochemical and molecular responses to water stress and rehydration in Mediterranean adapted tomato landraces.
Dementia
Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease.
Demyelinating Diseases
A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor.
A new EAE model of brain demyelination induced by intracerebroventricular pertussis toxin.
A new lipophilic amino alcohol, chemically similar to compound FTY720, attenuates the pathogenesis of experimental autoimmune encephalomyelitis by PI3K/Akt pathway inhibition.
Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage.
Chronic mechanical hypersensitivity in experimental autoimmune encephalomyelitis is regulated by disease severity and neuroinflammation.
IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis.
Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death.
P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice.
PARP-1 deletion promotes subventricular zone neural stem cells toward a glial fate.
PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity.
Dermatitis
High-content screening identifies inhibitors of oxidative stress-induced parthanatos: cytoprotective and anti-inflammatory effects of ciclopirox.
Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies.
Dermatitis, Allergic Contact
Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin.
Dermatitis, Contact
Engagement of CD47 inhibits the contact hypersensitivity response via the suppression of motility and B7 expression by Langerhans cells.
Genetic ablation of PARP-1 protects against oxazolone-induced contact hypersensitivity by modulating oxidative stress.
Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin.
Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity.
Poly(ADP-ribose) polymerase mediates inflammation in a mouse model of contact hypersensitivity.
Dermatitis, Phototoxic
Crosstalk between oxidative stress-induced apoptotic and autophagic signaling pathways in Zn(II) phthalocyanine photodynamic therapy of melanoma.
The PARP inhibitor PJ-34 sensitizes cells to UVA-induced phototoxicity by a PARP independent mechanism.
Diabetes Complications
Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications.
Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose?
Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation.
Does diabetes mellitus target motor neurons?
Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications.
Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in Mice.
Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications.
Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase (PARP) Activation in Experimental Diabetic Neuropathy: The Relation Is Revisited.
PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes.
PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis.
PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy.
PARP mediates structural alterations in diabetic cardiomyopathy.
Poly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy.
Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro.
Poly(ADP-ribose) polymerase is involved in the development of diabetic cystopathy via regulation of nuclear factor kappa B.
Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice.
Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.
Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme.
Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications.
The pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity.
Diabetes Insipidus, Nephrogenic
Effect of pertussis toxin on water metabolism in the rat.
Diabetes Mellitus
Adenosine thiamine triphosphate (AThTP) inhibits poly(ADP-ribose) polymerase-1 (PARP-1) activity.
Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase.
Effects of Trans-Resveratrol on hyperglycemia-induced abnormal spermatogenesis, DNA damage and alterations in poly (ADP-ribose) polymerase signaling in rat testis.
Nitrative stress and poly(ADP-ribose) polymerase activation in healthy and gestational diabetic pregnancies.
PARP as a Drug Target for the Therapy of Diabetic Cardiovascular Dysfunction.
PARP1 deficiency protects against hyperglycemia-induced neointimal hyperplasia by upregulating TFPI2 activity in diabetic mice.
Poly(ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus.
Poly(ADP-Ribose) Polymerase Activity and Coronary Artery Disease in Type 2 Diabetes Mellitus: An Observational and Bidirectional Mendelian Randomization Study.
Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update.
Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor.
Poly(ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury.
Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies.
Rapid 'glycaemic swings' induce nitrosative stress, activate poly(ADP-ribose) polymerase and impair endothelial function in a rat model of diabetes mellitus.
Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, angiographically verified coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus.
Role of poly (ADP-ribose) polymerase-1 and cytokines in acute renal injury in elderly Chinese patients with diabetes mellitus.
Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications.
Tempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus.
The parp-1 and bax genes as potential targets for treatment of the heart functioning impairments induced by type 1 diabetes mellitus.
Theobromine increases NAD?/Sirt-1 activity and protects the kidney under diabetic conditions.
Diabetes Mellitus, Experimental
Tempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus.
Diabetes Mellitus, Type 1
A dinucleotide repeat polymorphism at the poly(ADP-ribose) polymerase gene is not associated with predisposition to type 1 diabetes in French Caucasians.
A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice.
Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid.
Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase.
Effects of Trans-Resveratrol on hyperglycemia-induced abnormal spermatogenesis, DNA damage and alterations in poly (ADP-ribose) polymerase signaling in rat testis.
Enhanced G protein activation in IDDM patients with diabetic nephropathy.
Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.
Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes.
Poly(Adenosine 5'-Diphosphate-Ribose) Polymerase Inhibition Counteracts Multiple Manifestations of Experimental Type 1 Diabetic Nephropathy.
Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model.
The parp-1 and bax genes as potential targets for treatment of the heart functioning impairments induced by type 1 diabetes mellitus.
Unexpected sensitivity of nonobese diabetic mice with a disrupted poly(ADP-Ribose) polymerase-1 gene to streptozotocin-induced and spontaneous diabetes.
Diabetes Mellitus, Type 2
Enhanced NF?B Activity Impairs Vascular Function through PARP-1, SP-1 and COX2-Dependent Mechanisms in Type 2 Diabetes.
PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis.
Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes.
Poly(ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus.
Poly(ADP-Ribose) Polymerase Activity and Coronary Artery Disease in Type 2 Diabetes Mellitus: An Observational and Bidirectional Mendelian Randomization Study.
Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice.
Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity.
Poly(ADP-ribose)polymerase activity is reduced in circulating mononuclear cells from type 2 diabetic patients.
Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, angiographically verified coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus.
The relationship between obstructive sleep apnea and intra-epidermal nerve fiber density, PARP activation and foot ulceration in patients with type 2 diabetes.
The role of impaired insulin/IGF action in primary diabetic encephalopathy.
Diabetes, Gestational
[The severity of gestational diabetes mellitus affects microvascular dysfunction measured three years after pregnancy that may be related to increased oxidative stress].
Diabetic Cardiomyopathies
Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure.
Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme.
PARP mediates structural alterations in diabetic cardiomyopathy.
PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1? axis.
Poly(ADP-ribose) polymerase 1 inhibition protects cardiomyocytes from inflammation and apoptosis in diabetic cardiomyopathy.
Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy.
Diabetic Nephropathies
Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation.
Gallotannin ameliorates the development of streptozotocin-induced diabetic nephropathy by preventing the activation of PARP.
PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis.
PARP-1 and SIRT-1 are Interacted in Diabetic Nephropathy by Activating AMPK/PGC-1? Signaling Pathway.
Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model.
Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice.
Poly(ADP-ribose) polymerase-1 (PARP-1) gene deficiency alleviates diabetic kidney disease.
Psoralea corylifolia L. Seed Extract Attenuates Diabetic Nephropathy by Inhibiting Renal Fibrosis and Apoptosis in Streptozotocin-Induced Diabetic Mice.
Role for poly(ADP-ribose) polymerase activation in diabetic nephropathy, neuropathy and retinopathy.
Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.
Saxagliptin protects against diabetic nephropathy by inhibiting caspase 3/PARP-1-dependent nephrocyte apoptosis.
Diabetic Neuropathies
Biomarkers in diabetic neuropathy.
Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion.
Concurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy.
Effects of poly(ADP-ribose) polymerase inhibition on dysfunction of non-adrenergic non-cholinergic neurotransmission in gastric fundus in diabetic rats.
Emerging drugs for diabetic neuropathy.
Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy.
Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy.
Leu54Phe and Val762Ala polymorphisms in the poly(ADP-ribose)polymerase-1 gene are associated with diabetic polyneuropathy in Russian type 1 diabetic patients.
Lipoic Acid Decreases the Expression of Poly ADP-Ribose Polymerase and Inhibits Apoptosis in Diabetic Rats.
Low-dose poly(ADP-ribose) polymerase inhibitor-containing combination therapies reverse early peripheral diabetic neuropathy.
Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets.
New Therapeutic and Biomarker Discovery for Peripheral Diabetic Neuropathy: PARP Inhibitor, Nitrotyrosine, and Tumor Necrosis Factor-{alpha}
Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase (PARP) Activation in Experimental Diabetic Neuropathy: The Relation Is Revisited.
PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy.
Poly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy.
Poly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: a commentary on "PARP Inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy".
Protective effects of 4-amino1,8-napthalimide, a poly (ADP-ribose) polymerase inhibitor in experimental diabetic neuropathy.
Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy.
Treatment with Actovegin® Improves Sensory Nerve Function and Pathology in Streptozotocin-Diabetic Rats via Mechanisms Involving Inhibition of PARP Activation.
Diabetic Retinopathy
Aldose Reductase / Polyol Inhibitors For Diabetic Retinopathy.
Effect of the regimen of Gaoshan Hongjingtian on the mechanism of poly (ADP-ribose) polymerase regulation of nuclear factor kappa B in the experimental diabetic retinopathy.
Identification of low micromolar dual inhibitors for aldose reductase (ALR2) and poly (ADP-ribose) polymerase (PARP-1) using structure based design approach.
PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes.
Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression.
Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.
Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy.
Role of PARP-1 as a novel transcriptional regulator of MMP-9 in diabetic retinopathy.
The Poly(ADP-Ribose)Polymerase-1 Inhibitor 1,5-Isoquinolinediol Attenuate Diabetes-Induced NADPH Oxidase-Derived Oxidative Stress in Retina.
Diffuse Intrinsic Pontine Glioma
Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.
DiGeorge Syndrome
Over expression of LDOC1 and PARP1, two pro-apoptotic genes, in a patient with cryptorchidism and DiGeorge anomaly.
Diphtheria
A Belgian Serosurveillance/Seroprevalence Study of Diphtheria, Tetanus and Pertussis Using a Luminex xMAP Technology-Based Pentaplex.
A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly.
A fully liquid DTaP-IPV-Hep B-PRP-T hexavalent vaccine for primary and booster vaccination of healthy Mexican children.
A modified vaccine reduces the rate of large injection site reactions to the preschool booster dose of diphtheria-tetanus-acellular pertussis vaccine: results of a randomized, controlled trial.
A randomized controlled trial of two acellular pertussis-diphtheria-tetanus vaccines in primary immunization in Ghana: antibody responses and adverse reactions.
Acellular pertussis vaccine given by accelerated schedule: response of preterm infants.
Adequate tetanus but poor diphtheria and pertussis response to a Tdap booster in adolescents with juvenile systemic lupus erythematosus.
Adverse effects and sero-responses to an acellular pertussis/diphtheria/tetanus vaccine when combined with Haemophilus influenzae type b vaccine in an accelerated schedule.
Adverse reactions of a pertussis toxoid vaccine in a double-blind placebo-controlled trial.
Antibody persistence 2 and 3 years after booster vaccination of adolescents with recombinant acellular pertussis monovalent aPgen or combined TdaPgen vaccines.
Antibody response to diphtheria-tetanus-pertussis immunization in preterm infants who receive dexamethasone for chronic lung disease.
Antibody responses of healthy infants to concurrent administration of a bivalent haemophilus influenzae type b-hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines.
Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK.
Assessment of Intracellular Auto-Modification Levels of ARTD10 Using Mono-ADP-Ribose-Specific Macrodomains 2 and 3 of Murine Artd8.
Association of Routine Infant Vaccinations With Antibody Levels Among Preterm Infants.
Bacterial toxins inhibiting or activating small GTP-binding proteins.
Botulinum C2 toxin ADP-ribosylates actin.
Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.
Clinical reactions and immunogenicity of the BIKEN acellular diphtheria and tetanus toxoids and pertussis vaccine in 4- through 6-year-old US children.
Cloning, nucleotide sequence, and hybridization studies of the type IIb heat-labile enterotoxin gene of Escherichia coli.
Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins.
Comparative safety and immunogenicity of an acellular versus whole-cell pertussis component of diphtheria-tetanus-pertussis vaccines in Senegalese infants.
Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine. The Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine.
Comparison of 13 acellular pertussis vaccines: overview and serologic response.
Comparison of a fifth dose of a five-component acellular or a whole cell pertussis vaccine in children four to six years of age.
Comparison of the safety and immunogenicity of acellular (BIKEN) and whole-cell pertussis vaccines in 15- to 20-month-old children.
Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding.
Conservation of a common motif in enzymes catalyzing ADP-ribose transfer. Identification of domains in mammalian transferases.
Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin.
Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation.
Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China.
Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase.
Development and validation of a multiplex immunoassay for the simultaneous determination of serum antibodies to Bordetella pertussis, diphtheria and tetanus.
Development and Validation of Magnetic Bead Pentaplex Immunoassay for Simultaneous Quantification of murine serum IgG antibodies to Acellular Pertussis, Diphtheria and Tetanus Antigens used in combination vaccines.
Diphtheria, tetanus and pertussis antibodies in 10-year-old children before and after a booster dose of three toxoids: implications for the timing of a booster dose.
Effect of combination with an acellular pertussis, diphtheria, tetanus vaccine on antibody response to Hib vaccine (PRP-T).
Effect of local massage on vaccination: DTP and DTPa.
Effect of priming with diphtheria and tetanus toxoids combined with whole-cell pertussis vaccine or with acellular pertussis vaccine on the safety and immunogenicity of a booster dose of an acellular pertussis vaccine containing a genetically inactivated pertussis toxin in fifteen- to twenty-one-month-old children. Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine.
Enhanced post-licensure safety surveillance of a new recombinant acellular pertussis vaccine licensed as a monovalent (aP, Pertagen®) and tetanus, reduced-dose diphtheria combination (TdaP, Boostagen®) vaccine for immunization of adolescents and adults in Thailand.
Evaluation of a guinea pig model to assess interference in the immunogenicity of different components of a combination vaccine comprising diphtheria, tetanus and acellular pertussis (DTaP) vaccine and haemophilus influenzae type b capsular polysaccharide conjugate vaccine.
Experience with monocomponent acellular pertussis combination vaccines for infants, children, adolescents and adults-A review of safety, immunogenicity, efficacy and effectiveness studies and 15 years of field experience.
Expression and purification of a trivalent pertussis toxin-diphtheria toxin-tetanus toxin fusion protein in Escherichia coli.
Extensive swelling after booster doses of acellular pertussis-tetanus-diphtheria vaccines.
Fast, antigen-saving multiplex immunoassay to determine levels and avidity of mouse serum antibodies to pertussis, diphtheria, and tetanus antigens.
Generation of plant-derived recombinant DTP subunit vaccine.
Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice.
Genome-Wide Association Mapping of the Antibody Response to Diphtheria, Tetanus and Acellular Pertussis Vaccine in Mice.
Humoral immunity of dTap-IPV vaccine (REPEVAX(®)) administered one month after dT-IPV vaccine (REVAXIS(®)) in adults with unknown vaccination history.
Identification of amino acid residues essential for the enzymatic activities of pertussis toxin.
Identification of peptides that mimic the pertussis toxin binding site on bovine fetuin.
Immune response to a Tdap booster in vertically HIV-infected adolescents.
Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015.
Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019.
Immunogenicity and reactogenicity of a single dose of a diphtheria--tetanus--acellular pertussis component vaccine (DTaP) compared to a diphtheria--tetanus toxoid (Td) and a diphtheria toxoid vaccine (d) in adults.
Immunogenicity and reactogenicity of the component acellular pertussis vaccine produced by a combination of column purified pertussis toxin and filamentous haemagglutinin.
Immunogenicity and safety after booster vaccination of diphtheria, tetanus, and acellular pertussis in young adults: an open randomized controlled trial in Japan.
Immunogenicity and Safety of Monovalent Acellular Pertussis Vaccine at Birth: A Randomized Clinical Trial.
Immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type B conjugate vaccine (PRP-T) for primary and booster vaccinations.
Immunogenicity of combined diphtheria, tetanus, and pertussis vaccine given at 2, 3, and 4 months versus 3, 5, and 9 months of age.
Immunogenicity of primary DPT vaccination.
Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life.
Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium.
Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states.
Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule.
Local reactions and IgE antibodies to pertussis toxin after acellular diphtheria-tetanus-pertussis immunization.
mADP-RTs: versatile virulence factors from bacterial pathogens of plants and mammals.
Measuring immunoglobulin g antibodies to tetanus toxin, diphtheria toxin, and pertussis toxin with single-antigen enzyme-linked immunosorbent assays and a bead-based multiplex assay.
Novel bacterial ADP-ribosylating toxins: structure and function.
On technological and immunological benefits of multivalent single-injection microsphere vaccines.
Optimization of rPDT fusion protein expression by Escherichia coli in pilot scale fermentation: a statistical experimental design approach.
PARP inhibitors: polypharmacology versus selective inhibition.
PARP-1 and gene regulation: Progress and puzzles.
Persistence of antibody after accelerated immunisation with diphtheria/tetanus/pertussis vaccine.
Pertussis toxin-induced alterations of murine hepatic drug metabolism following administration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed.
Pertussis toxin-sensitive GTP-binding proteins regulate activation-induced apoptotic cell death of human natural killer cells.
Pertussis vaccination during pregnancy in Belgium: Follow-up of infants until 1 month after the fourth infant pertussis vaccination at 15 months of age.
Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study.
Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy.
Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I.
Poor immune responses to a birth dose of diphtheria, tetanus, and acellular pertussis vaccine.
Production of exoenzyme S by clinical isolates of Pseudomonas aeruginosa.
Protective immunogenicity of synthetic peptides selected from the amino acid sequence of Bordetella pertussis toxin subunit S1.
Protective immunogenicity of two synthetic peptides selected from the amino acid sequence of Bordetella pertussis toxin subunit S1.
Pseudomonas aeruginosa exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A.
Quantitative determination of bioactive proteins in diphtheria tetanus acellular pertussis (DTaP) vaccine by liquid chromatography tandem mass spectrometry.
Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women.
Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function.
Safety and immunogenicity of a combined pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliovirus and Haemophilus influenzae type b-tetanus conjugate vaccine in infants, compared with a whole cell pertussis pentavalent vaccine.
Safety and immunogenicity of Biken acellular pertussis vaccine in combination with diphtheria and tetanus toxoid as a fifth dose at four to six years of age. Munich Vaccine Study Group.
Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers.
Safety and immunogenicity of six acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fifth dose in four- to six-year-old children.
Sequence and structural links between distant ADP-ribosyltransferase families.
Seroepidemiology of diphtheria and pertussis in Beijing, China: A cross-sectional study.
Seroepidemiology of diphtheria and pertussis in Chongqing, China: serology-based evidence of Bordetella pertussis infection.
Seroprevalence and placental transportation of maternal antibodies specific for Neisseria meningitidis serogroup C, Haemophilus influenzae type B, diphtheria, tetanus, and pertussis.
Seroprevalence of antibodies against diphtheria, tetanus, and pertussis among healthy Thai adolescents.
Seroprevalence of antibodies for pertussis and diphtheria among people leaving or entering China: a cross-sectional study.
Seroprevalence of antibodies to pertussis and diphtheria among healthy adults in China.
Serum antibodies to diphtheria-tetanus-pertussis vaccine components in Argentine children.
Serum antibodies to the components of diphtheria-tetanus-pertussis vaccine in Polish children related to vaccination status.
Spotlight on Tdap? vaccine (Covaxis®) as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis: in children (aged ?4 years), adolescents, and adults.
Standardization of acellular pertussis vaccine by assay of serum neutralizing antibodies to pertussis toxin (antitoxin): analogy with diphtheria toxoid.
Structural Basis for Lack of ADP-Ribosyltransferase Activity in Poly(ADP-Ribose) Polymerase-13/Zinc Finger Antiviral Protein.
Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa.
Tdap booster to adolescents with juvenile idiopathic arthritis on and off anti-TNF agents is safe and immunogenic.
Tdap(5) vaccine (covaxis®): a review of its use as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis in children (aged ?4 years), adolescents, and adults.
The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins.
The Effect of Maternal Pertussis Immunization on Infant Vaccine Responses to a Booster Pertussis-Containing Vaccine in Vietnam.
The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks.
The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines.
Use of biotinylated NAD to label and purify ADP-ribosylated proteins.
Vaccines, emerging viruses, and how to avoid disaster.
[Induction of protective immunity for Bordetella pertussis by nasal inoculation of pertussis vaccine in mice]
[Seroepidemiological Studies on Pertussis, Diphtheria and Tetanus among Nursing Students Enrolled between 1994 and 2011 in the Kitakyushu District].
[The risk of pertussis and diphtheria infections among pediatric healthcare workers in Japan]
DNA Repair-Deficiency Disorders
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Combinatorial Therapy of High Dose Vitamin C and PARP Inhibitors in DNA Repair Deficiency: A Series of 8 Patients.
Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer.
Hereditary cancer syndromes: utilizing DNA repair deficiency as therapeutic target.
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer.
Inhibition of mTOR downregulates expression of DNA repair proteins and is highly efficient against BRCA2-mutated breast cancer in combination to PARP inhibition.
Mitochondrial protein ATPase family, AAA domain containing 3A correlates with radioresistance in glioblastoma.
PARP inhibition: A promising therapeutic target in ovarian cancer.
Predictive biomarkers for cancer therapy with PARP inhibitors.
Supraphysiological androgens suppress prostate cancer growth through androgen receptor-mediated DNA damage.
The BET inhibitor JQ1 attenuates double-strand break repair and sensitizes models of pancreatic ductal adenocarcinoma to PARP inhibitors.
The Landscape and Therapeutic Implications of Molecular Profiles in Epithelial Ovarian Cancer.
Trastuzumab resistant HER2+ breast cancer cells retain sensitivity to poly (ADP-ribose) polymerase (PARP) inhibition.
Utility of Homologous Recombination Deficiency Biomarkers Across Cancer Types.
dna-3-methyladenine glycosylase ii deficiency
Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition.
Down Syndrome
Differential expression of PARP1 mRNA in leucocytes of patients with down's syndrome.
The role of poly(ADP-ribose)polymerase in the induction of sister chromatid exchanges and micronuclei by mitomycin C in Down's syndrome cells as compared to euploid cells.
Drug-Related Side Effects and Adverse Reactions
Identification of different side effects between PARP inhibitors and their polypharmacological multi-target rationale.
Dyslexia
The complex of TFII-I, PARP1, and SFPQ proteins regulates the DYX1C1 gene implicated in neuronal migration and dyslexia.
Dyslipidemias
Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE mice: effects on eNOS and oxidative stress.
[Gender-specific factors of ischemic stroke among atrial fibrillation patients].
Ectropion
The Curcumin Analogs 2-Pyridyl Cyclohexanone Induce Apoptosis via Inhibition of the JAK2-STAT3 Pathway in Human Esophageal Squamous Cell Carcinoma Cells.
Ehrlichiosis
Specific processing of poly(ADP-ribose) polymerase, accompanied by activation of caspase-3 and elevation/reduction of ceramide/hydrogen peroxide levels, during induction of apoptosis in host HL-60 cells infected by the human granulocytic ehrlichiosis (HGE) agent.
Encephalitis
Damage and repair of DNA in HIV encephalitis.
Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling.
Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system.
The role of poly(ADP-ribose) polymerase-1 in CNS disease.
Encephalomyelitis
Amifostine ameliorates induction of experimental autoimmune encephalomyelitis: Effect on reactive oxygen species/NLRP3 pathway.
Analysis of experimental autoimmune encephalomyelitis induced in F344 rats by pertussis toxin administration.
Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment.
Beyond dna repair,the immunological role of parp-1 and its siblings.
Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model.
Crawling phagocytes recruited in the brain vasculature after pertussis toxin exposure through IL6, ICAM1, and ITG?M.
Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness.
Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta a H-2b mice.
Differential roles of Fas ligand in spontaneous and actively induced autoimmune encephalomyelitis.
Diversified serum IgG response involving non-myelin CNS proteins during experimental autoimmune encephalomyelitis.
Elevated axonal membrane permeability and its correlation with motor deficits in an animal model of multiple sclerosis.
Experimental Autoimmune Encephalomyelitis Develops in CC Chemokine Receptor 7-deficient Mice with Altered T-cell Responses.
Immunomodulation By Subchronic Low Dose 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin.
Immunomodulation of murine experimental autoimmune encephalomyelitis by pertussis toxin: the protective activity, but not the disease-enhancing activity, can be attributed to the nontoxic B-oligomer.
Induction of Autoimmunity by Expansion of Autoreactive CD4+CD62Llow Cells In Vivo.
Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats.
Kinetics of IL-17- and interferon-gamma-producing PLPp-specific CD4 T cells in EAE induced by coinjection of PLPp/IFA with pertussis toxin in SJL mice.
Long-term suppression of EAE relapses by pharmacological impairment of epitope spreading.
Native, but not genetically inactivated, pertussis toxin protects mice against experimental allergic encephalomyelitis.
Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin.
Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis.
Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice.
PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis.
PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity.
Pertussis toxin attenuates experimental autoimmune encephalomyelitis by upregulating neuronal vascular endothelial growth factor.
Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE.
Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals.
Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis.
Pertussis toxin modulates the immune response to neuroantigens injected in incomplete Freund's adjuvant: induction of Th1 cells and experimental autoimmune encephalomyelitis in the presence of high frequencies of Th2 cells.
Pertussis toxin promotes relapsing-remitting experimental autoimmune encephalomyelitis in Lewis rats.
Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells.
Pertussis toxin-induced hyperacute autoimmune encephalomyelitis in Lewis rats is correlated with increased expression of inducible nitric oxide synthase and tumor necrosis factor alpha.
Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis.
Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis.
Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019.
Rapid depletion of peripheral antigen-specific T cells in TCR-transgenic mice after oral administration of myelin basic protein.
Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodies.
Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease.
Special AT-rich sequence binding protein 1 is required for maintenance of T cell receptor responsiveness and development of experimental autoimmune encephalomyelitis.
The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis.
The regulatory effect of liuwei dihuang pills on cytokines in mice with experimental autoimmune encephalomyelitis.
TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease.
Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Amifostine ameliorates induction of experimental autoimmune encephalomyelitis: Effect on reactive oxygen species/NLRP3 pathway.
Analysis of experimental autoimmune encephalomyelitis induced in F344 rats by pertussis toxin administration.
Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment.
Beyond dna repair,the immunological role of parp-1 and its siblings.
Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model.
Crawling phagocytes recruited in the brain vasculature after pertussis toxin exposure through IL6, ICAM1, and ITG?M.
Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness.
Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta a H-2b mice.
Diversified serum IgG response involving non-myelin CNS proteins during experimental autoimmune encephalomyelitis.
Elevated axonal membrane permeability and its correlation with motor deficits in an animal model of multiple sclerosis.
Experimental Autoimmune Encephalomyelitis Develops in CC Chemokine Receptor 7-deficient Mice with Altered T-cell Responses.
Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints.
Immunomodulation By Subchronic Low Dose 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin.
Immunomodulation of murine experimental autoimmune encephalomyelitis by pertussis toxin: the protective activity, but not the disease-enhancing activity, can be attributed to the nontoxic B-oligomer.
Induction of Autoimmunity by Expansion of Autoreactive CD4+CD62Llow Cells In Vivo.
Inhibition by CTLA4Ig of experimental allergic encephalomyelitis.
Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats.
Kinetics of IL-17- and interferon-gamma-producing PLPp-specific CD4 T cells in EAE induced by coinjection of PLPp/IFA with pertussis toxin in SJL mice.
Long-term suppression of EAE relapses by pharmacological impairment of epitope spreading.
Native, but not genetically inactivated, pertussis toxin protects mice against experimental allergic encephalomyelitis.
Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin.
Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis.
Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice.
PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis.
PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity.
PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis.
Pertussis toxin attenuates experimental autoimmune encephalomyelitis by upregulating neuronal vascular endothelial growth factor.
Pertussis toxin induces angiogenesis in brain microvascular endothelial cells.
Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE.
Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals.
Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis.
Pertussis toxin modulates the immune response to neuroantigens injected in incomplete Freund's adjuvant: induction of Th1 cells and experimental autoimmune encephalomyelitis in the presence of high frequencies of Th2 cells.
Pertussis toxin promotes relapsing-remitting experimental autoimmune encephalomyelitis in Lewis rats.
Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells.
Pertussis toxin-induced hyperacute autoimmune encephalomyelitis in Lewis rats is correlated with increased expression of inducible nitric oxide synthase and tumor necrosis factor alpha.
Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis.
Poly(ADP-ribose) polymerase inhibitors.
Poly(ADP-ribose) polymerase-1 activation in a primate model of multiple sclerosis.
Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis.
Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019.
Rapid depletion of peripheral antigen-specific T cells in TCR-transgenic mice after oral administration of myelin basic protein.
Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodies.
Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease.
Special AT-rich sequence binding protein 1 is required for maintenance of T cell receptor responsiveness and development of experimental autoimmune encephalomyelitis.
The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis.
The regulatory effect of liuwei dihuang pills on cytokines in mice with experimental autoimmune encephalomyelitis.
The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation.
The third signal in T cell-mediated autoimmune disease?
TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease.
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity.
Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Venezuelan Equine
Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replication.
Endodermal Sinus Tumor
PARP expression in germ cell tumours.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Poly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors.
Endometrial Neoplasms
An olaparib window-of-opportunity trial in patients with early-stage endometrial carcinoma: POLEN study.
Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells.
Autophagy in the physiological endometrium and cancer.
Current Systemic Treatment Landscape of Advanced Gynecologic Malignancies.
Durable response in a woman with recurrent low-grade endometrioid endometrial cancer and a germline BRCA2 mutation treated with a PARP inhibitor.
Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro.
Evaluation of the management of PARP inhibitor toxicities in ovarian and endometrial cancer within a multi-institution health-system.
Expression of DNA repair proteins in endometrial cancer predicts disease outcome.
Expression of poly-ADP-ribose polymerase (PARP) in endometrial adenocarcinoma: Prognostic potential.
Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells.
Hypomethylation of ETS transcription factor binding sites and upregulation of PARP1 expression in endometrial cancer.
Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors.
Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo.
MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway.
Moving From Mutation to Actionability.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP and PD-1/PD-L1 checkpoint inhibition in recurrent or metastatic endometrial cancer.
PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis.
PARP inhibitors and immunotherapy in ovarian and endometrial cancers.
PARP inhibitors in BRCA gene-mutated ovarian cancer and beyond.
PARP Inhibitors in Endometrial Cancer: Current Status and Perspectives.
Poly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues.
Poly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors.
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.
PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy.
Research progress of PARP inhibitor monotherapy and combination therapy for endometrial cancer.
Successful treatment of a patient with brain metastases from endometrial cancer using Niraparib: a case report.
The SGK1 inhibitor SI113 induces autophagy, apoptosis, and endoplasmic reticulum stress in endometrial cancer cells.
TRAF4 knockdown triggers synergistic lethality with simultaneous PARP1 inhibition in endometrial cancer.
[Influence of pertussis toxin on GPER-mediated activation of phosphatidylinositol 3-kinase/protein kinase B signaling induced by 17?-estradiol in endometrial carcinoma cells].
Endometriosis
Immunohistochemistry expression of targeted therapies biomarkers in ovarian clear cell and endometrioid carcinomas (type I) and endometriosis.
Endotoxemia
Heterotrimeric G?(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis.
Nicotinamide increases systemic vascular resistance in ovine endotoxemia.
Role of lipopolysaccharide and cecal ligation and puncture on blood coagulation and inflammation in sensitive and resistant mice models.
Role of PARP on iNOS pathway during endotoxin-induced acute lung injury.
Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia.
Enterocolitis, Necrotizing
Poly(ADP-Ribose) Polymerase-1: A Novel Therapeutic Target in Necrotizing Enterocolitis.
Eosinophilia
PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice.
PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model.
Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation.
Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia.
Eosinophilic Esophagitis
Correlation of increased PARP14 and CCL26 expression in biopsies from children with eosinophilic esophagitis.
Ependymoma
Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors.
PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.
Epilepsy
Amygdaloid kindling elicits persistent changes in pertussis toxin-catalyzed ADP-ribosylation.
Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro.
Poly(ADP-ribose) polymerase inhibition protects epileptic hippocampal neurons from apoptosis via suppressing Akt-mediated apoptosis-inducing factor translocation in vitro.
TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice.
Epilepsy, Absence
Pertussis toxin decreases absence seizures and GABA(B) receptor binding in thalamus of a genetically prone rat (GAERS).
Epstein-Barr Virus Infections
Generation of human monoclonal antibodies that confer protection against pertussis toxin.
Erectile Dysfunction
Poly(Adenosine diphosphate-ribose) polymerase inhibition preserves erectile function in rats after cavernous nerve injury.
Poly(ADP-ribose) polymerase inhibition reverses nitrergic neurovascular dysfunctions in penile erectile tissue from streptozotocin-diabetic mice.
Erythema
Increase in intradermal vascular permeability caused by pertussis toxin from Bordetella pertussis.
Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin.
Esophageal Neoplasms
Involvement of homologous recombination in the synergism between cisplatin and poly(ADP-ribose) polymerase inhibition.
PARP inhibitor olaparib sensitizes esophageal carcinoma cells to fractionated proton irradiation.
PARP1 Gene Polymorphisms and the Prognosis of Esophageal Cancer Patients from Cixian High-Incidence Region in Northern China.
PARP1 rs1136410 C/C genotype associated with an increased risk of esophageal cancer in smokers.
Single?cell intratumoral stemness analysis reveals the involvement of cell cycle and DNA damage repair in two different types of esophageal cancer.
The Synthetic ?-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 Pathways.
Esophageal Squamous Cell Carcinoma
Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines.
PARP1 Gene Polymorphisms and the Prognosis of Esophageal Cancer Patients from Cixian High-Incidence Region in Northern China.
PARP1 rs1136410 C/C genotype associated with an increased risk of esophageal cancer in smokers.
Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma.
Essential Hypertension
Enhanced G protein activation in IDDM patients with diabetic nephropathy.
Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated.
Exanthema
Association of apoptosis-related microsatellite polymorphisms on chromosome 1q in Taiwanese systemic lupus erythematosus patients.
Eye Abnormalities
Anterior uveitis in murine relapsing experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS).
Fallopian Tube Neoplasms
Niraparib for the Treatment of Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.
Fanconi Anemia
A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia.
Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers.
Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel.
DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity.
DNA Repair Deficient Chinese Hamster Ovary Cells Exhibiting Differential Sensitivity to Charged Particle Radiation under Aerobic and Hypoxic Conditions.
HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair.
No abnormalities in the NAD+ ADP-ribosyltransferase (polymerizing) gene of transformed cells from a Fanconi's anemia patient.
Rare mutations in XRCC2 increase the risk of breast cancer.
Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition.
The cellular control enzyme polyADP ribosyl transferase is eliminated in cultured Fanconi anemia fibroblasts at confluency.
The Fanconi anemia cell line HSC536N is not sensitive to interferon-gamma and does not cleave PARP in response to FAS-mediated cell killing.
Fatty Liver
2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (TiparpH532A) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality.
Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome.
Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality.
Metabolic roles of poly(ADP-ribose) polymerases.
Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease.
PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.
PARP1-mediated PPAR? poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease.
PARPs in lipid metabolism and related diseases.
Pertussis toxin induces fatty liver, hyperlipemia and ketosis in hamsters.
Steatohepatitis: PARP inhibition protective against alcoholic steatohepatitis and NASH.
Fatty Liver, Alcoholic
PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.
Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice.
Steatohepatitis: PARP inhibition protective against alcoholic steatohepatitis and NASH.
Fetal Alcohol Spectrum Disorders
Nicotinamide Inhibits Ethanol-Induced Caspase-3 and PARP-1 Over-activation and Subsequent Neurodegeneration in the Developing Mouse Cerebellum.
Fibroma
PARP-1 expression as a prognostic factor in Desmoid-type fibromatosis.
Fibromatosis, Aggressive
PARP-1 expression as a prognostic factor in Desmoid-type fibromatosis.
Fibrosarcoma
HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells.
Response of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation.
Role of JNK-1 regulation in the protection of contact-inhibited fibroblasts from oxidative stress.
Friedreich Ataxia
Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34.
Frontotemporal Lobar Degeneration
Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA.
Gallbladder Neoplasms
PARP1 rs1136410 (A/G) polymorphism is associated with early age of onset of gallbladder cancer.
Triptolide induces s phase arrest and apoptosis in gallbladder cancer cells.
Ganglion Cysts
A G Protein Mediates the Inhibition of the Voltage-Dependent Potassium M Current by Muscarine, LHRH, Substance P and UTP in Bullfrog Sympathetic Neurons.
Poly(ADP-ribose) polymerase inhibition improves corneal epithelial innervation and wound healing in diabetic rats.
Gastrointestinal Diseases
Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement.
Safety profile of poly (ADP-ribose) polymerase (PARP) inhibitors in cancer: a network meta-analysis of randomized controlled trials.
Gastrointestinal Neoplasms
Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement.
Identification of PARP-1 in cancer stem cells of gastrointestinal cancers: A preliminary study.
Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers.
Genetic Diseases, Inborn
The function of poly (ADP-ribosylation) in DNA breakage and rejoining.
Giant Cell Tumors
Bisphosphonates may reduce recurrence in giant cell tumor by inducing apoptosis.
Glioblastoma
A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas.
A New Pathway Promotes Adaptation of Human Glioblastoma Cells to Glucose Starvation.
A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.
A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.
A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study.
A randomized phase II trial of veliparib, radiotherapy and temozolomide in patients with unmethylated MGMT glioblastoma: the VERTU study.
ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461.
ABCB1, ABCG2 and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy.
An 18F-Labeled Poly(ADP-ribose) Polymerase Positron Emission Tomography Imaging Agent.
Associations between polymorphisms in DNA repair genes and glioblastoma.
BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair.
BRCAness as a Biomarker of Susceptibility to PARP Inhibitors in Glioblastoma Multiforme.
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone.
Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells.
Cellular and biochemical antileukemic mechanisms of the meroterpenoid Oncocalyxone A.
Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor.
Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma: Is PTEN predictive of response?
Comparative status of activated ERK1/2 and PARP cleavage in human gliomas.
Deubiquitinating enzyme 4 facilitates chemoresistance in glioblastoma by inhibiting P53 activity.
Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts.
Discovery of a perinecrotic 60 kDa MDM2 isoform within glioma spheroids and glioblastoma biopsy material.
Discriminating radiation injury from recurrent tumor with [18F]PARPi and amino acid PET in mouse models.
Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems.
Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma.
Effect of p53 activity on the sensitivity of human glioblastoma cells to PARP-1 inhibitor in combination with topoisomerase I inhibitor or radiation.
Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines.
Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System.
EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma.
Enhanced efficacy of combined HDAC and PARP targeting in glioblastoma.
Eradication of LIG4-deficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent.
Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma.
Exploitation of a novel phenothiazine derivative for its anti-cancer activities in malignant glioblastoma.
Expression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model.
Functional Biological Activity of Sorafenib as a Tumor-Treating Field Sensitizer for Glioblastoma Therapy.
Glioblastoma Cells Containing Mutations in the Cohesin Component STAG2 Are Sensitive to PARP Inhibition.
Glioblastoma multiforme: overview of current treatment and future perspectives.
Heat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties.
Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme.
In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016.
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy.
Interleukin-4 Enhances PARP-Dependent DNA Repair Activity In Vitro.
Intratumor administration of interleukin 13 receptor-targeted cytotoxin induces apoptotic cell death in human malignant glioma tumor xenografts.
Investigation of U-251 cell death triggered by flavonoid luteolin: towards a better understanding on its anticancer property against glioblastomas.
LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model.
Luteolin Decreases Epidermal Growth Factor Receptor-Mediated Cell Proliferation and Induces Apoptosis in Glioblastoma Cell Lines.
MEG-3-mediated Wnt/?-catenin signaling pathway controls the inhibition of tunicamycin-mediated viability in glioblastoma.
Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.
Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models.
Overcoming Resistance of Glioblastoma to Conventional Cytotoxic Therapies by the Addition of PARP Inhibitors.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma.
PARP inhibitor cyanine dye conjugate with enhanced cytotoxic and antiproliferative activity in patient derived glioblastoma cell lines.
PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity.
PARP mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma.
PARP Targeted Alpha-Particle Therapy Enhances Response to PD-1 Immune-Checkpoint Blockade in a Syngeneic Mouse Model of Glioblastoma.
PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells.
PARP-1 protein expression in glioblastoma multiforme.
PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma.
PARP1-Targeted Radiotherapy in Mouse Models of Glioblastoma.
PARP3 interacts with FoxM1 to confer glioblastoma cell radioresistance.
PARPi-FL--a fluorescent PARP1 inhibitor for glioblastoma imaging.
Pharmacokinetics, safety and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial.
Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide.
Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue.
Poly (ADP-Ribose) Polymerase 1 Protein Expression in Normal Pancreas and Pancreatic Adenocarcinoma.
Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells.
Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation.
Poly(ADPR)polymerase-1 signalling of the DNA damage induced by DNA topoisomerase I poison in D54(p53wt) and U251(p53mut) glioblastoma cell lines.
Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells.
Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation.
PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.
Quercetin Increases the Efficacy of Glioblastoma Treatment Compared to Standard Chemoradiotherapy by the Suppression of PI-3-Kinase-Akt Pathway.
Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma.
Radioiodinated PARP1 tracers for glioblastoma imaging.
Radiosensitization Effect of Talazoparib, a Parp Inhibitor, on Glioblastoma Stem Cells Exposed to Low and High Linear Energy Transfer Radiation.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Rationale for PARP inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.
RECQ1 Promotes Stress Resistance and DNA Replication Progression Through PARP1 Signaling Pathway in Glioblastoma.
Restoration of Temozolomide Sensitivity by PARP Inhibitors in Mismatch Repair Deficient Glioblastoma is Independent of Base Excision Repair.
Restricted Delivery of Talazoparib Across the Blood-Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma.
SB365 induces apoptosis and suppresses proliferation of glioblastoma cells.
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Silibinin Induced Human Glioblastoma Cell Apoptosis Concomitant with Autophagy through Simultaneous Inhibition of mTOR and YAP.
Sustained inhibition of PARP-1 activity delays glioblastoma recurrence by enhancing radiation-induced senescence.
Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo.
Synthetic chenodeoxycholic acid derivatives inhibit glioblastoma multiform tumor growth in vitro and in vivo.
Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma.
Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy.
Temozolomide: Mechanisms of Action, Repair and Resistance.
The Combination PARP Inhibitor Olaparib With Temozolomide in an Experimental Glioblastoma Model.
The effect of iodine-131 beta-particles in combination with A-966492 and Topotecan on radio-sensitization of glioblastoma: An in-vitro study.
Treatment of Pediatric Glioblastoma with Combination Olaparib and Temozolomide Demonstrates 2-Year Durable Response.
Tumor treating fields combined with a poly (adenosine diphosphate-ribose) polymerase inhibitor during radiotherapy for rapidly progressing IDH-wildtype diffuse astrocytoma: a case report.
Urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells.
Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation.
VRK1 Depletion Facilitates the Synthetic Lethality of Temozolomide and Olaparib in Glioblastoma Cells.
Glioma
2'-Hydroxy C16-Ceramide Induces Apoptosis-Associated Proteomic Changes in C6 Glioma Cells.
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor.
A novel selenadiazole derivative induces apoptosis in human glioma cells by dephosphorylation of AKT.
A therapeutic update on PARP inhibitors: implications in the treatment of glioma.
ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461.
Activation of a K+ conductance by bradykinin and by inositol-1,4,5-trisphosphate in rat glioma cells: involvement of intracellular and extracellular Ca2+.
Adjuvant immunotherapy of C6 glioma in rats with pertussis toxin.
ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells.
AG490 influences UCN-01-induced cytotoxicity in Glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation.
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor.
Assays for G-protein-coupled receptor signaling using RGS-insensitive Galpha subunits.
Association and interactions between DNA repair gene polymorphisms and adult glioma.
Association between DNA repair gene polymorphisms and risk of glioma: A systematic review and meta-analysis.
Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis.
Association Between PARP1 Single Nucleotide Polymorphism and Brain Tumors.
ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma.
Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA.
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Capitalizing on ATRX loss in glioma via PARP inhibition: Comment on "Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity" by Garbarino et al.
Celastrol enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway.
Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells.
Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme.
Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma.
Comparative status of activated ERK1/2 and PARP cleavage in human gliomas.
Concomitant treatment with pertussis toxin plus temozolomide increases the survival of rats bearing intracerebral RG2 glioma.
Contribution of caspase-independent pathway to apoptosis in malignant glioma induced by carbon ion beams.
Deoxypodophyllotoxin triggers parthanatos in glioma cells via induction of excessive ROS.
Differential effects of cholera toxin and pertussis toxin on the c-fos and c-jun mRNA expression in rat C6 glioma cells.
Differential PARP cleavage: an indication for existence of multiple forms of cell death in human gliomas.
Doxorubicin-mediated apoptosis in glioma cells requires NFAT3.
Effect of chronic D-Ala,2 D-Leu5-enkephalin or pertussis toxin treatment on the high-affinity state of delta opioid receptor in neuroblastoma x glioma NG108-15 hybrid cells.
Effect of pertussis toxin treatment on the down-regulation of opiate receptors in neuroblastoma X glioma NG108-15 hybrid cells.
EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma.
Electro-hyperthermia inhibits glioma tumorigenicity through the induction of E2F1-mediated apoptosis.
Endogenous regulator of g protein signaling proteins reduce {mu}-opioid receptor desensitization and down-regulation and adenylyl cyclase tolerance in C6 cells.
Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model.
Endothelin-elicited stimulation of phospholipase C is mediated by guanine nucleotide binding protein(s).
Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types.
Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90.
Expression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model.
Fucoxanthin induces apoptosis in human glioma cells by triggering ROS-mediated oxidative damage and regulating MAPKs and PI3K/AKT pathways.
Genetic advances in glioma: susceptibility genes and networks.
Glioma risk associates with polymorphisms of DNA repair genes, XRCC1 and PARP1.
Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells.
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.
H2O2-induced cell death in human glioma cells: role of lipid peroxidation and PARP activation.
Idazoxan down-regulates beta-adrenoceptors on C6 glioma cells in vitro.
Identification of a 116 kDa protein able to bind 1,3-bis(2-chloroethyl)-1-nitrosourea-damaged DNA as poly(ADP-ribose) polymerase.
Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase.
Impact of four lncRNA polymorphisms (rs2151280, rs7763881, rs1136410, and rs3787016) on glioma risk and prognosis: A case-control study.
Incidence and prognostic value of multiple gene promoter methylations in gliomas.
Induction of apoptosis in glioma cells requires cell-to-cell contact with human umbilical cord blood stem cells.
Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status.
Involvement of poly(ADP-ribose) polymerase-1 in Chinese patients with glioma: a potential target for effective patient care.
JNK Activation Contributes to Oxidative Stress-Induced Parthanatos in Glioma Cells via Increase of Intracellular ROS Production.
Large-conductance K+ channel openers induce death of human glioma cells.
Linarin suppresses glioma through inhibition of NF-?B/p65 and up-regulating p53 expression in vitro and in vivo.
Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells.
Molecular mechanisms for the activation of Ca2+-permeable nonselective cation channels by endothelin-1 in C6 glioma cells.
mTOR, S6 and AKT expression in relation to proliferation and apoptosis/autophagy in glioma.
Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin.
N-methylpurine DNA glycosylase and DNA polymerase {beta} modulate BER inhibitor potentiation of glioma cells to temozolomide.
NADPH treatment decreases C6 glioma cell survival by increasing oxidative stress.
Noscapine induces apoptosis in human glioma cells by an apoptosis-inducing factor-dependent pathway.
NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape.
Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway.
Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (Gi) in membranes of neuroblastoma x glioma hybrid cells.
Oroxyloside inhibits human glioma progression by suppressing proliferation, metastasis and inducing apoptosis related pathways.
Oxidative stress and PARP activation mediate the NADH-induced decrease in glioma cell survival.
Oxidative stress induces apoptosis in C6 glioma cells: involvement of mitogen-activated protein kinases and nuclear factor kappa B.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.
PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma.
PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation.
PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma.
PARP1 expression in pediatric central nervous system tumors.
Pediatric high-grade glioma: identification of poly(ADP-ribose) polymerase as a potential therapeutic target.
Pertussis toxin decreases opiate receptor binding and adenylate inhibition in a neuroblastoma x glioma hybrid cell line.
Pertussis Toxin Is a Robust and Selective Inhibitor of High Grade Glioma Cell Migration and Invasion.
Pertussis toxin treatment prevents 5-HT(5a) receptor-mediated inhibition of cyclic AMP accumulation in rat C6 glioma cells.
Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells.
Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.
Poly(ADP-ribose) polymerase-independent potentiation of nitrosourea cytotoxicity by 3-aminobenzamide in human malignant glioma cells.
Polymorphisms in DNA Repair Gene and Susceptibility to Glioma: A Systematic Review and Meta-Analysis Based on 33 Studies with 15 SNPs in 9 Genes.
Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers.
Pre-treatment or Post-treatment of Human Glioma Cells With BIX01294, the Inhibitor of Histone Methyltransferase G9a, Sensitizes Cells to Temozolomide.
Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures.
Relationship between genetically determined telomere length and glioma risk.
Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: mechanisms and therapeutic potential.
Restoration of Temozolomide Sensitivity by PARP Inhibitors in Mismatch Repair Deficient Glioblastoma is Independent of Base Excision Repair.
Rhaponticum carthamoides transformed root extract inhibits human glioma cells viability, induces double strand DNA damage, H2A.X phosphorylation, and PARP1 cleavage.
Rho/ROCK pathway as a target of tumor therapy.
Role of a protein regulating guanine nucleotide binding in phosphoinositide breakdown and calcium mobilization by bradykinin in neuroblastoma X glioma hybrid NG108-15 cells: effects of pertussis toxin and cholera toxin on receptor-mediated signal transduction.
Selenocysteine induces apoptosis in human glioma cells: evidence for TrxR1-targeted inhibition and signaling crosstalk.
Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.
Synergism in cytosolic Ca2+ mobilization between bradykinin and agonists for pertussis toxin-sensitive G-protein-coupled receptors in NG 108-15 cells.
Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent.
Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma.
Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.
Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas.
TCH1036, a indeno[1,2-c]quinoline derivative, potentially inhibited the growth of human brain malignant glioma (GBM) 8401 cells via suppression of the expression of Suv39h1 and PARP.
Telomerase subunits expression variation between biopsy samples and cell lines derived from malignant glioma.
Tetrandrine and caffeine modulated cell cycle and increased glioma cell death via caspase-dependent and caspase-independent apoptosis pathways.
The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity.
The effects of phorbol 12-myristate 13-acetate, cholera toxin, prostaglandin E2 and norepinephrine on inducible nitric oxide synthase activation induced by lipopolysaccharide in C6 cells.
The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No.
The presumed atypical chemokine receptor CXCR7 signals through G(i/o) proteins in primary rodent astrocytes and human glioma cells.
The Selective Acetamidine-Based iNOS Inhibitor CM544 Reduces Glioma Cell Proliferation by Enhancing PARP-1 Cleavage In Vitro.
The transcription factor Forkhead box P3 (FoxP3) is expressed in glioma cells and associated with increased apoptosis.
Treatment of Pediatric Glioblastoma with Combination Olaparib and Temozolomide Demonstrates 2-Year Durable Response.
Whole-body hyperthermia and ADPRT inhibition in experimental treatment of brain tumors.
Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets.
[PARP inhibitors and radiotherapy: rational and prospects for a clinical use].
[Toxic effects of Vitamin C combined with temozolomide on glioma cells and its mechanism].
Gliosarcoma
Cellular regulation of poly(ADP) ribosylation of proteins. I. Comparison of hepatocytes, cultured cells and liver nuclei and the influence of varying concentrations of NAD.
Glomerulonephritis
Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis.
Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation.
Glomerulonephritis, IGA
Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura.
Glucose Intolerance
Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes.
Graft vs Host Disease
Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells.
Reduced PARP1 as a Serum Biomarker for Graft Rejection in Kidney Transplantation.
Graves Disease
Association of PARP-1, NF-?B, NF-?BIA and IL-6, IL-1? and TNF-? with Graves Disease and Graves Ophthalmopathy.
Poly (ADP-Ribose) Polymerase-1 (PARP-1) in Chinese patients with Graves Disease and Graves Ophthalmopathy.
Graves Ophthalmopathy
Association of PARP-1, NF-?B, NF-?BIA and IL-6, IL-1? and TNF-? with Graves Disease and Graves Ophthalmopathy.
Poly (ADP-Ribose) Polymerase-1 (PARP-1) in Chinese patients with Graves Disease and Graves Ophthalmopathy.
Growth Hormone-Secreting Pituitary Adenoma
Phorbol ester and phospholipase C-induced growth hormone secretion from pituitary somatotroph adenoma cells in culture: effects of somatostatin, bromocriptine, and pertussis toxin.
Haemophilus Infections
Effect of pertussis toxin on susceptibility of infant rats to Haemophilus influenzae type b.
Head and Neck Neoplasms
Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers.
Cetuximab augments cytotoxicity with poly (adp-ribose) polymerase inhibition in head and neck cancer.
Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth.
Efficacy of poly (ADP-ribose) polymerase inhibitor olaparib against head and neck cancer cells: Predictions of drug sensitivity based on PAR-p53-NF-?B interactions.
Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer.
Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427.
PARP inhibitors in head and neck cancer: Molecular mechanisms, preclinical and clinical data.
Photodynamic therapy (PDT) resistance by PARP1 regulation on PDT-induced apoptosis with autophagy in head and neck cancer cells.
Poly (ADP-ribose) polymerase inhibitor efficacy in head and neck cancer.
Synergistic inhibition of head and neck tumor growth by green tea (-)-epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor.
The poly(ADP-Ribose) polymerase inhibitor ABT-888 reduces radiation-induced nuclear EGFR and augments head and neck tumor response to radiotherapy.
Heart Arrest
Inhibition of poly(adp-ribose) polymerase reduces cardiomyocytic apoptosis after global cardiac arrest under cardiopulmonary bypass.
INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation.
Mesenteric injury after cardiopulmonary bypass: role of poly(adenosine 5'-diphosphate-ribose) polymerase.
Neuronal accumulation of poly(ADP-ribose) after brain ischaemia.
Poly(ADP-ribose) polymerase inhibitor PJ-34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest.
Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass.
Heart Diseases
1,25(OH)2 D3 improves cardiac dysfunction, hypertrophy and fibrosis through PARP1/SIRT1/mTOR related mechanisms in Type 1 diabetes.
Association study of hsa_circ_0001946, hsa-miR-7-5p and PARP1 in coronary atherosclerotic heart disease.
Comment on: Association study of hsa_circ_0001946, hsa-miR-7-5p and PARP1 in coronary atherosclerotic heart disease.
In vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters.
PARP1 induces cardiac fibrosis by mediating mTOR activity.
Salvage of nicotinamide adenine dinucleotide plays a critical role in the bioenergetic recovery of post-hypoxic cardiomyocytes.
[Research progress of poly (ADP-ribose) polymerase-1 in cardiac diseases.]
Heart Failure
Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure.
Activation of the poly(ADP-ribose) polymerase pathway in human heart failure.
Additional use of immunostaining for active caspase 3 and cleaved actin and PARP fragments to detect apoptosis in patients with chronic heart failure.
AG-690/11026014, a novel PARP-1 inhibitor, protects cardiomyocytes from AngII-induced hypertrophy.
Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure.
Cardioprotective effects of poly(ADP-ribose) polymerase inhibition.
Desensitization of cardiac beta-adrenoceptor signaling with heart failure produced by myocardial infarction in the rat. Evidence for the role of Gi but not Gs or phosphorylating proteins.
DNA Damage, an Innocent Bystander in Atrial Fibrillation and Other Cardiovascular Diseases?
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Effect of L-2286, a poly(ADP-ribose)polymerase inhibitor and enalapril on myocardial remodeling and heart failure.
Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms.
G?i)- and G?i3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes.
Immobilization Stress With ?2-Adrenergic Stimulation Induces Regional and Transient Reduction of Cardiac Contraction Through Gi Coupling in Rats.
Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure.
Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy.
Mitochondrial protective effects of PARP-inhibition in hypertension-induced myocardial remodeling and in stressed cardiomyocytes.
Myocardial cell death and regeneration during progression of cardiac hypertrophy to heart failure.
Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential.
Nitrosative stress and pharmacological modulation of heart failure.
Oxidative Stress-Related Parthanatos of Circulating Mononuclear Leukocytes in Heart Failure.
PARP inhibition and postinfarction myocardial remodeling.
PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats.
PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.
PARP-1 inhibition attenuates cardiac fibrosis induced by myocardial infarction through regulating autophagy.
PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1.
PARP-inhibitor treatment prevents hypertension induced cardiac remodeling by favorable modulation of heat shock proteins, Akt-1/GSK-3? and several PKC isoforms.
Pertussis toxin treatment of whole blood. A novel approach to assess G protein function in congestive heart failure.
Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure.
Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.
Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update.
Poly(ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure.
Poly(ADP-ribose) polymerase regulates myocardial calcium handling in doxorubicin-induced heart failure.
Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy.
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity.
Protective effect of lncRNA CRNDE on myocardial cell apoptosis in heart failure by regulating HMGB1 cytoplasm translocation through PARP-1.
Regulation of kinase cascade activation and heat shock protein expression by poly(ADP-ribose) polymerase inhibition in doxorubicin-induced heart failure.
Revealing the synergistic mechanism of Shenfu Decoction for anti-heart failure through network pharmacology strategy.
Role of altered G-protein expression in the regulation of myocardial adenylate cyclase activity and force of contraction in spontaneous hypertensive cardiomyopathy in rats.
Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure.
Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors.
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.
The effect of pertussis toxin on beta-adrenoceptor responses in isolated cardiac myocytes from noradrenaline-treated guinea-pigs and patients with cardiac failure.
The Promise of Proteomics for the Study of ADP-Ribosylation.
Heart Valve Diseases
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Hemangiosarcoma
PARP inhibition in UV-associated angiosarcoma preclinical models.
Hematologic Neoplasms
Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site.
Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells.
Population Pharmacokinetic Modeling of Veliparib (ABT-888) in Patients with Non-Hematologic Malignancies.
The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy, Use as a Single Agent in Susceptible Patients, and Techniques Used to Identify Susceptible Patients.
The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy; Use as a Single Agent in Susceptible Patients; Techniques Used to Identify Susceptible Patients.
Hemoglobinuria
Neutrophil activation in response to immune complex-bearing endothelial cells depends on the functional cooperation of Fc gamma RII (CD32) and Fc gamma RIII (CD16).
Hemoglobinuria, Paroxysmal
Neutrophil activation in response to immune complex-bearing endothelial cells depends on the functional cooperation of Fc gamma RII (CD32) and Fc gamma RIII (CD16).
Hemorrhagic Septicemia, Viral
Molecular characterization and expressional analysis of two poly (ADP-ribose) polymerase (PARP) domain-containing Gig2 isoforms in rockfish (Sebastes schlegelii) and their antiviral activity against viral hemorrhagic septicemia virus.
Hepatitis
Influence of diet free of NAD-precursors on acetaminophen hepatotoxicity in mice.
Murine Coronavirus Infection Activates the Aryl Hydrocarbon Receptor in an Indoleamine 2,3-Dioxygenase-Independent Manner, Contributing to Cytokine Modulation and Proviral TCDD-Inducible-PARP Expression.
PARP2 deficiency affects invariant-NKT-cell maturation and protects mice from Concanavalin A-induced liver injury.
Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis.
Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis.
TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation.
Hepatitis A
Concomitant use of VAQTA® with PedvaxHIB® and Infanrix® in 12 to 17 month old children.
Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015.
Hepatitis B
A fully liquid DTaP-IPV-Hep B-PRP-T hexavalent vaccine for primary and booster vaccination of healthy Mexican children.
A Randomized, Controlled Study of DTaP-IPV-HB-PRP-T, a Fully Liquid Hexavalent Vaccine, Administered in a 3-, 5- and 11- to 12-month Schedule.
Antibody responses of healthy infants to concurrent administration of a bivalent haemophilus influenzae type b-hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines.
Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015.
Immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type B conjugate vaccine (PRP-T) for primary and booster vaccinations.
Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life.
Interaction of hepatitis B virus X protein with PARP1 results in inhibition of DNA repair in hepatocellular carcinoma.
No associations of polymorphisms in ADPRT with hepatitis B virus clearance and hepatocellular carcinoma occurrence in a Korean population.
Novel poly (ADP-ribose) polymerase 1 binding motif in hepatitis B virus core promoter impairs DNA damage repair.
PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population.
Reduced ADP-ribosylation by PARP1 natural polymorphism V762A and by PARP1 inhibitors enhance Hepatitis B virus replication.
Hepatitis C
Hepatitis C virus induces oxidative stress and DNA damage by regulating DNAPKCs, ATM, ATR and PARP mediated signaling and guards cell from cancerous condition by upregulating RB, P53 and downregulating VEGF.
Hepatoblastoma
PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma.
Wnt/?-catenin signaling as a useful therapeutic target in hepatoblastoma.
Hereditary Breast and Ovarian Cancer Syndrome
Hereditary pancreatic cancer.
[Molecular Targeted Therapies for Hereditary Cancer Syndrome].
Heredodegenerative Disorders, Nervous System
XRCC1 protein; Form and function.
Herpes Simplex
ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase ?-TrCP.
Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase.
Herpes simplex virus requires poly(ADP-ribose) polymerase activity for efficient replication and induces extracellular signal-related kinase-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1.
Inhibition of poly(ADP-ribose)polymerase stimulates extrachromosomal homologous recombination in mouse Ltk-fibroblasts.
Herpes Zoster
A guanine nucleotide-binding regulatory protein in human sperm mediates acrosomal exocytosis induced by the human zona pellucida.
Calcium influx into mouse spermatozoa activated by solubilized mouse zona pellucida, monitored with the calcium fluorescent indicator, fluo-3. Inhibition of the influx by three inhibitors of the zona pellucida induced acrosome reaction: tyrphostin A48, pertussis toxin, and 3-quinuclidinyl benzilate.
Characterization of the biologic activities of a recombinant human zona pellucida protein 3 expressed in human ovarian teratocarcinoma (PA-1) cells.
Differential sensitivity of progesterone- and zona pellucida-induced acrosome reactions to pertussis toxin.
Evidence for the role of heterotrimeric guanine nucleotide-binding regulatory proteins in the regulation of the mouse sperm adenylyl cyclase by the egg's zona pellucida.
Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015.
Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019.
Inhibition of G protein in human sperm and its influence on acrosome reaction and zona pellucida binding.
Histiocytic Sarcoma
[Role of proteins in Fas-mediated apoptosis in tumor cells and lymphocytes co-cultured in vitro]
histone acetyltransferase deficiency
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.
HIV Infections
A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis.
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide.
Inhibition of intra- and extra-cellular Tat function and HIV expression by pertussis toxin B-oligomer.
Minireview, The oxidative stress-induced niacin sink (OSINS) model for HIV pathogenesis.
Pertussis toxin B-oligomer inhibits HIV infection and replication in hu-PBL-SCID mice.
The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity.
Huntington Disease
Discovery of bioactive small-molecule inhibitor of poly adp-ribose polymerase: implications for energy-deficient cells.
Modulation of Inflammasome and Pyroptosis by Olaparib, a PARP-1 Inhibitor, in the R6/2 Mouse Model of Huntington's Disease.
PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington's Disease.
Selective Sparing of Striatal Interneurons after Poly (ADP-Ribose) Polymerase 1 Inhibition in the R6/2 Mouse Model of Huntington's Disease.
Hyperalgesia
Activation of G(i) induces mechanical hyperalgesia poststress or inflammation.
Chronic morphine administration and in vivo pertussis toxin treatment induce hyperalgesia and enhance 3H-nitrendipine binding.
Concurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy.
Histamine H4 receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress.
Intracerebroventricular treatment of mice with pertussis toxin induces hyperalgesia and enhances 3H-nitrendipine binding to synaptic membranes: similarity with morphine tolerance.
Intrathecal pertussis toxin induces thermal hyperalgesia: involvement of excitatory and inhibitory amino acids.
Intrathecal pertussis toxin produces hyperalgesia and allodynia in mice.
Kappa- and delta-opioids block sympathetically dependent hyperalgesia.
Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in Mice.
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect?
N-Methyl-d-aspartate receptor antagonist d-AP5 prevents pertussis toxin-induced alterations in rat spinal cords by inhibiting increase in concentrations of spinal CSF excitatory amino acids and downregulation of glutamate transporters.
PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy.
PARP inhibitors attenuate chemotherapy-induced painful neuropathy.
PARP-1-regulated TNF-? expression in the dorsal root ganglia and spinal dorsal horn contributes to the pathogenesis of neuropathic pain in rats.
Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat.
Pharmacologic reversal of pertussis toxin-induced thermal allodynia in mice.
Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice.
Protein kinase C inhibitor chelerythrine attenuates the morphine-induced excitatory amino acid release and reduction of the antinociceptive effect of morphine in rats injected intrathecally with pertussis toxin.
Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin.
Reversal of pertussis toxin-induced thermal allodynia by muscarinic cholinergic agonists in mice.
RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice.
Some new insights into the effects of opioids in phasic and tonic nociceptive tests.
Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway.
Ultra-low-dose naloxone restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in PTX-treated rats.
Hypercholesterolemia
Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries.
Hyperglycemia
Amelioration of diabetes-induced neurobehavioral and neurochemical changes by melatonin and nicotinamide: implication of oxidative stress-PARP pathway.
Antioxidant therapy in diabetic complications: what is new?
Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis.
Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade.
Comparative study of peripheral neuropathy and nerve regeneration in NOD and ICR diabetic mice.
Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid.
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation.
Effect of D-glucose feeding on mortality induced by sepsis.
Hyperglycemia accentuates and ketonemia attenuates hypoglycemia-induced neuronal injury in the developing rat brain.
Mangiferin Enhanced Autophagy via Inhibiting mTORC1 Pathway to Prevent High Glucose-Induced Cardiomyocyte Injury.
Molecular targets of diabetic vascular complications and potential new drugs.
PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis.
Parp inhibition prevents ten eleven translocase enzyme activation and hyperglycemia induced DNA demethylation.
PARP-1 inhibition alleviates diabetic cardiac complications in experimental animals.
Poly(ADP-ribose) polymerase 1 inhibition protects cardiomyocytes from inflammation and apoptosis in diabetic cardiomyopathy.
Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.
Poly(ADP-ribose)polymerase activity is reduced in circulating mononuclear cells from type 2 diabetic patients.
Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice.
Poly-ADP-ribose polymerase inhibition enhances ischemic and diabetic wound healing by promoting angiogenesis.
Propolis ethanol extract abrogates hyperglycemia, lipotoxicity, and lowered hepatic poly (ADP-ribose) polymerase protein level in male albino rats.
Recurrent hypoinsulinemic hyperglycemia in neonatal rats increases PARP-1 and NF-?B expression and leads to microglial activation in the cerebral cortex.
Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin.
The activation of ?2-adrenergic receptor in the spinal cord lowers sepsis-induced mortality.
The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes.
Treatment with insulin inhibits poly(ADP-ribose)polymerase activation in a rat model of endotoxemia.
Hyperhomocysteinemia
Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels.
Poly (ADP-Ribose) Polymerase Inhibition Attenuates Atherosclerotic Plaque Development in ApoE-/- Mice with Hyperhomocysteinemia.
Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by hyperhomocysteinemia in rats.
Hyperinsulinism
Acute stress-induced hyperinsulinemia in the pertussis toxin-treated rat: possible role of humoral beta-cell-tropic factors.
Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying.
The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines.
Hyperkinesis
Neuropeptide Y and sigma ligand (JO 1784) act through a Gi protein to block the psychological stress and corticotropin-releasing factor-induced colonic motor activation in rats.
Hyperlipidemias
PARPs in lipid metabolism and related diseases.
Pertussis toxin induces fatty liver, hyperlipemia and ketosis in hamsters.
Poly (ADP-Ribose) Polymerase Inhibition Attenuates Atherosclerotic Plaque Development in ApoE-/- Mice with Hyperhomocysteinemia.
Hypersensitivity
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress.
A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition.
Advanced Oxidative Protein Products Cause Pain Hypersensitivity in Rats by Inducing Dorsal Root Ganglion Neurons Apoptosis via NADPH Oxidase 4/c-Jun N-terminal Kinase Pathways.
Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance.
Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin.
APTO-253 Is a New Addition to the Repertoire of Drugs that Can Exploit DNA BRCA1/2 Deficiency.
Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells.
Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment.
Base excision repair defects invoke hypersensitivity to PARP inhibition.
Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1.
Beyond dna repair,the immunological role of parp-1 and its siblings.
Break of unresponsiveness of delayed-type hypersensitivity to sheep red blood cells by pertussis toxin.
Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma.
CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair.
Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.
Decreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase beta-deficient mice.
Delayed-type hypersensitivity responses in mice treated with pertussis toxin and betamethasone.
DNA repair and cell cycle checkpoint defects in a mouse model of 'BRCAness' are partially rescued by 53BP1 deletion.
Effects of pertussis toxin (PT) on T-cell populations sensitized for delayed-type hypersensitivity in mice.
Effects of pertussis toxin on delayed-type hypersensitivity responses and on the activity of suppressor T cells on the responses.
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
Enhancement of histamine-induced vascular leakage by pertussis toxin in SJL/J mice but not BALB/c mice.
Human CHD1 is required for early DNA-damage signaling and is uniquely regulated by its N terminus.
Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity.
Hypersensitivity to clinically useful alkylating agents and radiation in poly(ADP-ribose) polymerase-deficient cell lines.
IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors.
Impact of carboplatin hypersensitivity and desensitization on patients with recurrent ovarian cancer.
Increased PARP-1 Association with DNA in Alkylation Damaged, PARP-Inhibited Mouse Fibroblasts.
Inhibiting Mitochondrial DNA Ligase III? Activates Caspase 1-Dependent Apoptosis in Cancer Cells.
Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling.
LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation.
Loss of the p12 subunit of DNA polymerase delta leads to a defect in HR and sensitization to PARP inhibitors.
Mechanism by which pertussis toxin breaks unresponsiveness of delayed-type hypersensitivity to sheep red blood cells in mice.
Microsatellite instability induced mutations in DNA repair genes Ctip and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors in myeloidmalignancies.
Modulation of hypersensitivity to oxidative DNA damage in ATM defective cells induced by potassium bromate by inhibition of the Poly (ADP-ribose) polymerase (PARP).
Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage.
PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.
Pertussis adjuvant prolongs intestinal hypersensitivity.
Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28.
Pertussis toxin stimulates hypersensitivity and enhances nerve-mediated antigen uptake in rat intestine.
Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms.
Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications.
Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.
Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications.
RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.
Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair.
Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2.
Targeting poly(ADP-ribose) polymerase activity for cancer therapy.
The ADP-ribosyltransferase PARP10/ARTD10 interacts with Proliferating Cell Nuclear Antigen (PCNA) and is required for DNA damage tolerance.
The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity.
The PARP-1 inhibitor Olaparib suppresses BRCA1 protein levels, increases apoptosis and causes radiation hypersensitivity in BRCA1
The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy.
The USP1/UAF1 complex promotes double-strand break repair through homologous recombination.
Use of type I and type IV hypersensitivity responses to define the immunopharmacological profile of drugs.
USP-11 as a predictive and prognostic factor following neoadjuvant therapy in women with breast cancer.
Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors.
[PARP inhibitors and radiotherapy: rational and prospects for a clinical use].
Hypersensitivity, Delayed
Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice.
Hypertension
Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging.
Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation.
Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade.
Contribution of poly(ADP-ribose) polymerase to endothelial dysfunction and hypertension in a rat model of pre-eclampsia.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Effects of quinapril, losartan and hydralazine on cardiac hypertrophy and beta-adrenergic neuroeffector mechanisms in transgenic (mREN2)27 rats.
Impaired 3',5'-cyclic adenosine monophosphate-mediated signaling in immediate early responsive gene X-1-deficient vascular smooth muscle cells.
Inactivation of enhanced expression of G(i) proteins by pertussis toxin attenuates the development of high blood pressure in spontaneously hypertensive rats.
Influence of pertussis toxin pretreatment on the development of L-NAME-induced hypertension.
Inhibition of PARP prevents angiotensin II-induced aortic fibrosis in rats.
iNOS induction and PARP-1 activation in human atherosclerotic lesions: an immunohistochemical and ultrastructural approach.
Knockdown of Inhibitory Guanine Nucleotide Binding Protein Gi?-2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats.
MicroRNAs Modulate Oxidative Stress in Hypertension through PARP-1 Regulation.
PARP-inhibitor treatment prevents hypertension induced cardiac remodeling by favorable modulation of heat shock proteins, Akt-1/GSK-3? and several PKC isoforms.
PCB-induced endothelial cell dysfunction: role of poly(ADP-ribose) polymerase.
Pertussis toxin-sensitive G-proteins and regulation of blood pressure in the spontaneously hypertensive rat.
Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin.
Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure.
Therapeutic options following second-line platinum-based chemotherapy in patients with recurrent ovarian cancer: Comparison of active surveillance and maintenance treatment.
[Gender-specific factors of ischemic stroke among atrial fibrillation patients].
Hypertension, Pulmonary
Caffeine to prevent respiratory failure and improve outcome in infant pertussis.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Effects of calcium channel antagonists and pertussis toxin on noradrenaline-induced contractions in pulmonary artery from pulmonary hypertensive rats.
MicroRNAs and PARP: co-conspirators with ROS in pulmonary hypertension. Focus on "miR-223 reverses experimental pulmonary arterial hypertension".
Pertussis toxin promotes pulmonary hypertension in an infant mouse model of Bordetella pertussis infection.
Poly (ADP-ribose) polymerase-1: An emerging target in right ventricle dysfunction associated with pulmonary hypertension.
Hyperthyroidism
Pertussis toxin effects on adenylate cyclase activity, cyclic AMP accumulation and lipolysis in adipocytes from hypothyroid, euthyroid and hyperthyroid rats.
Poly(ADP-ribose) polymerase is affected early by thyroid state during liver regeneration in rats.
Poly(ADP-ribosyl)ation of proteins and germ cell development in hyperthyroid rat testes.
Tissue- and subunit-specific regulation of G-protein expression by hypo- and hyperthyroidism.
Hypertrophy, Right Ventricular
Poly (ADP-ribose) polymerase-1: An emerging target in right ventricle dysfunction associated with pulmonary hypertension.
Hypoglycemia
Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia.
Infection of newborn piglets with Bordetella pertussis: a new model for pertussis.
Postnatal Age Influences Hypoglycemia-induced Poly(ADP-ribose) Polymerase-1 Activation in the Brain Regions of Rats.
Prevention of acute/severe hypoglycemia-induced neuron death by lactate administration.
Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment.
Pyruvate administration reduces recurrent/moderate hypoglycemia-induced cortical neuron death in diabetic rats.
Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying.
Signaling pathways involved in thrombin-induced cell protection.
The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines.
Zinc release contributes to hypoglycemia-induced neuronal death.
Hypotension
Activation and modulation of cardiac poly-adenosine diphosphate ribose polymerase activity in a rat model of brain death.
Inhibition of Nitro-Oxidative Stress Attenuates Pulmonary and Systemic Injury Induced by High-Tidal Volume Mechanical Ventilation.
Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat.
The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia.
Vascular beta-adrenoceptor blocking activity of endotoxin and pertussis toxin from Bordetella pertussis in rats.
Hypothyroidism
Tissue- and subunit-specific regulation of G-protein expression by hypo- and hyperthyroidism.
Idiopathic Pulmonary Fibrosis
Effects of PARP-1 Deficiency and Histamine H4 Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice.
Regulation of myofibroblast differentiation by poly(ADP-ribose) polymerase 1.
Immune Complex Diseases
[THE EFFECT OF OF POLY(ADP-RIBOSE) POLYMERASE INHIBITOR 4-HYDROXY-QUINAZOLINE ON DEATH OF IMMUNE CELLS UNDER IMMUNE COMPLEX-MEDIATED INJURY IN MICE].
Immune System Diseases
A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation.
Infarction, Middle Cerebral Artery
Delayed PARP-1 Inhibition Alleviates Post-stroke Inflammation in Male Versus Female Mice: Differences and Similarities.
Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain.
Influence of electroacupuncture on the mRNA of heat shock protein 70 and 90 in brain after cerebral ischemia/reperfusion of rats.
Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment.
MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model.
Neuroprotective effect of 4-amino-1,8-napthalimide, a poly(ADP ribose) polymerase inhibitor in middle cerebral artery occlusion-induced focal cerebral ischemia in rat.
Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats.
Neuroprotective effects of KCL-440, a new poly(ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model.
Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation.
Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke.
Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model.
Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage.
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.
Poly(ADP-ribose) polymerase inhibition by cilostazol is implicated in the neuroprotective effect against focal cerebral ischemic infarct in rat.
Poly(ADP-Ribose)Polymerase 1 (PARP-1) Activation and Ca(2+) Permeable ?-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Channels in Post-Ischemic Brain Damage: New Therapeutic Opportunities?
Sex differences in minocycline-induced neuroprotection after experimental stroke.
Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke.
Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death.
Infections
Acellular pertussis vaccine in children with perinatal human immunodeficiency virus-type 1 infection.
Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells.
Activation of caspases in pig kidney cells infected with wild-type and CrmA/SPI-2 mutants of cowpox and rabbitpox viruses.
Activation of cell signaling pathways is dependant on the biotype of bovine viral diarrhea viruses type 2.
Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori.
Acute exacerbation of idiopathic pulmonary fibrosis induced by pertussis: the first case report.
Adenovirus-Mediated Gene Transfer of FKHRL1 Triple Mutant Efficiently Induces Apoptosis in Melanoma Cells.
Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice.
ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication.
ADP-ribosylation by exoenzyme T of Pseudomonas aeruginosa induces an irreversible effect on the host cell cytoskeleton in vivo.
Age-specific long-term course of IgG antibodies to pertussis toxin after symptomatic infection with Bordetella pertussis.
An Interaction with PARP-1 and Inhibition of Parylation Contribute to Attenuation of DNA Damage Signaling by the Adenovirus E4orf4 Protein.
Analogous IgG subclass response to pertussis toxin in vaccinated children, healthy or affected by whooping cough.
Antibodies recognizing protective pertussis toxin epitopes are preferentially elicited by natural infection versus acellular immunization.
Antibody responses to pertussis toxin display different kinetics after clinical Bordetella pertussis infection than after vaccination with an acellular pertussis vaccine.
Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression.
Apoptosis induction in BEFV-infected Vero and MDBK cells through Src-dependent JNK activation regulates caspase-3 and mitochondria pathways.
Apoptosis of human retina and retinal pigment cells induced by human cytomegalovirus infection.
Apoptosis-inducing factor contributes to epithelial cell apoptosis induced by enteropathogenic Escherichia coli.
Assessment of IgA anti-PT and IgG anti-ACT reflex testing to improve Bordetella pertussis serodiagnosis in recently vaccinated subjects.
Assessment of Poly(ADP-ribose) Polymerase1 (PARP1) expression and activity in cells purified from blood and milk of dairy cattle.
Bax is activated during rotavirus-induced apoptosis through the mitochondrial pathway.
Biochemical Variations in Cytolytic Activity of Ortho- and Paramyxoviruses in Human Lung Tumor Cell Culture.
Blockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of beta1-integrin, ERK, and NF-kappaB.
Bordetella pertussis and Bordetella parapertussis: two immunologically distinct species.
Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity.
Bordetella pertussis infection in mice: correlation of specific antibodies against two antigens, pertussis toxin, and filamentous hemagglutinin with mouse protectivity in an intracerebral or aerosol challenge system.
Bordetella pertussis infection of human respiratory epithelial cells up-regulates intercellular adhesion molecule-1 expression: role of filamentous hemagglutinin and pertussis toxin.
Bordetella Pertussis Toxin does not induce the release of pro-inflammatory cytokines in human whole blood.
Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance.
Caspase activation and specific cleavage of substrates after coxsackievirus B3-induced cytopathic effect in HeLa cells.
Caspase-mediated cleavage of adenovirus early region 1A proteins.
Caspase-mediated cleavage of the feline calicivirus capsid protein.
Cell-mediated immune responses to antigens of Bordetella pertussis and protection against pertussis in school children.
Characterization of a key neutralizing epitope on pertussis toxin recognized by monoclonal antibody 1B7.
Characterization of individual human antibodies binding pertussis toxin stimulated by acellular immunization.
Characterization of murine lung inflammation after infection with parental Bordetella pertussis and mutants deficient in adhesins or toxins.
Chick embryo, a model to study the lethal activity of pertussis toxin, infectivity of Bordetella pertussis, and their neutralization by immune sera.
Chlamydia pneumoniae alters mildly oxidized low-density lipoprotein-induced cell death in human endothelial cells, leading to necrosis rather than apoptosis.
Chromatin remodeling factor encoded by ini1 induces G1 arrest and apoptosis in ini1-deficient cells.
Clustered cases of Bordetella pertussis infection cause high levels of IgG antibodies against pertussis toxin in adolescents in Gaobeidian city, China.
Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells.
Comparative analysis of key immune protection factors in H9N2 avian influenza viruses infected and immunized specific pathogen-free chicken.
Comparison of polymerase chain reaction, culture, and western immunoblot serology for diagnosis of Bordetella pertussis infection.
Conflicting effects of poly(ADP-ribose) polymerase inhibitor on cell-mediated and virion-mediated HTLV-1 infection.
Constitutive inositol phosphate formation in cytomegalovirus-infected human fibroblasts is due to expression of the chemokine receptor homologue pUS28.
Construction of Bordetella pertussis strains that overproduce genetically inactivated pertussis toxin.
Contribution of exoenzyme S to the virulence of Pseudomonas aeruginosa.
Contribution of the B oligomer to the protective activity of genetically attenuated pertussis toxin.
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity.
Coxiella burnetii induces apoptosis during early stage infection via a caspase-independent pathway in human monocytic THP-1 cells.
Crimean-Congo haemorrhagic fever replication interplays with regulation mechanisms of apoptosis.
Delayed role of tumor necrosis factor- alpha in overcoming the effects of pertussis toxin.
Determination of serum neutralizing antibodies reveals important difference in quality of antibodies against pertussis toxin in children after infection.
Differences in avidity of IgG antibodies to pertussis toxin after acellular pertussis booster vaccination and natural infection.
Differences in epitope-specific antibodies to pertussis toxin after infection and acellular vaccinations.
DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration.
DNA vaccine encoding pertussis toxin S1 subunit induces protection against Bordetella pertussis in mice.
Effect of pertussis toxin on susceptibility of infant rats to Haemophilus influenzae type b.
Efficacy of pertussis components in an acellular vaccine, as assessed in a murine model of respiratory infection and a murine intracerebral challenge model.
Efficient retroviral infection of mammalian cells is blocked by inhibition of poly(ADP-ribose) polymerase activity.
Elucidation of linear epitopes of pertussis toxin using overlapping synthetic decapeptides: identification of a human B-cell determinant in the S1 subunit indicative of acute infections.
Enhanced
Epithelial anion transporter pendrin contributes to inflammatory lung pathology in mouse models of Bordetella pertussis infection.
Epitope specificity of three anti-pertussis toxin monoclonal antibodies with dissimilar effects in assays of toxin neutralizing activity.
Estimated and reported incidence of pertussis in Estonian adults: A seroepidemiological study.
Evaluation of an immunoglobulin G enzyme-linked immunosorbent assay for pertussis toxin and filamentous hemagglutinin in diagnosis of pertussis in Senegal.
Evaluation of inactivated Bordetella pertussis as a delivery system for the immunization of mice with Pneumococcal Surface Antigen A.
Evaluation of serology and nasopharyngeal cultures for diagnosis of pertussis in a vaccine efficacy trial.
Evidence that myocardial pertussis toxin substrates are uniquely altered in acute murine Chagas' disease in a manner unrelated to myocardial dysfunction.
Examining the Role of Actin-Plasma Membrane Association in Pseudomonas aeruginosa Infection and Type III Secretion Translocation in Migratory T24 Epithelial Cells.
ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury.
Expression of cytotoxicity-associated genes in Marek's disease virus-infected chickens.
Flavonol morin targets host ACE2, IMP-?, PARP-1 and viral proteins of SARS-CoV-2, SARS-CoV and MERS-CoV critical for infection and survival: a computational analysis.
Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection.
Gene transfer of constitutively active caspase-3 induces apoptosis in a human hepatoma cell line.
Genetic and pharmacological inhibition of poly(ADP-ribose) polymerase-1 interferes in the chlamydial life cycle.
Genetic approaches to study Pseudomonas aeruginosa protein antigens.
Genital antibody responses in mice after intranasal infection with an attenuated candidate vector strain of Bordetella pertussis.
Hepatitis C virus induced a novel apoptosis-like death of pancreatic beta cells through a caspase 3-dependent pathway.
Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase.
High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer.
Hippocampal poly(ADP-Ribose) polymerase 1 and caspase 3 activation in neonatal bornavirus infection.
Histamine release from basophils in childhood: age dependency and inhibition by pertussis infection and pertussis toxin.
HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation.
Host relieves lnc-IRAK3-3-sequestered miR-891b to attenuate apoptosis in Enterovirus 71 infection.
Human cytomegalovirus UL38 protein blocks apoptosis.
Human immunodeficiency virus-1 infection requires pertussis toxin sensitive G-protein-coupled signalling and mediates cAMP downregulation.
Human serum antibody responses to Bordetella pertussis infection and pertussis vaccination.
Identification of Salmonella typhi promoters activated by invasion of eukaryotic cells.
IL-1R signaling is required to overcome the effects of pertussis toxin and for efficient infection or vaccination induced immunity against Bordetella pertussis.
Immunologic and epidemiologic experience of vaccination with a monocomponent pertussis toxoid vaccine.
Impact of a pertussis booster vaccination program in adolescents and adults on the epidemiology of pertussis in Austria.
Impaired formation of the second messenger cAMP in mononuclear blood cells of children with pertussis.
In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells.
Incidence of pertussis infection in healthcare workers.
Increase in de novo HBV DNA integrations in response to oxidative DNA damage or inhibition of poly(ADP-ribosyl)ation.
Increased population prevalence of low pertussis toxin antibody levels in young children preceding a record pertussis epidemic in Australia.
Induction of apoptosis and cleavage of poly(ADP-ribose) polymerase by cytopathic bovine viral diarrhea virus infection.
Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein.
Inhibition of host cell apoptosis by Toxoplasma gondii is accompanied by reduced activation of the caspase cascade and alterations of poly(ADP-ribose) polymerase expression.
Inhibition of ICE-like proteases inhibits apoptosis and increases virus production during adenovirus infection.
Inhibition of PARP1 Dampens Pseudorabies Virus Infection through DNA Damage-Induced Antiviral Innate Immunity.
Inhibition of poly(ADP-ribose) polymerase interferes with Trypanosoma cruzi infection and proliferation of the parasite.
Inhibition of Poly(ADP-ribose)polymerase impairs Epstein Barr Virus lytic cycle progression.
Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states.
Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer.
Interaction of Sindbis virus non-structural protein 3 with poly(ADP-ribose) polymerase 1 in neuronal cells.
Interferon-gamma levels in serum and bronchoalveolar lavage fluid of mice infected with Bordetella pertussis.
Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis.
Is rheumatoid arthritis a consequence of natural selection for enhanced tuberculosis resistance?
Isolation and characterization of transposon-induced mutants of Pseudomonas aeruginosa deficient in production of exoenzyme S.
Kinetics of the IgG antibody response to pertussis toxin after infection with B. pertussis.
Lethal infection by Bordetella pertussis mutants in the infant mouse model.
Loss of dendritic cell migration and impaired resistance to Leishmania donovani infection in mice deficient in CCL19 and CCL21.
Loss of multi-epitope specificity in memory CD4(+) T cell responses to B. Pertussis with age.
Mechanism of pertussis toxin B oligomer-mediated protection against Bordetella pertussis respiratory infection.
Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply.
Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.
MMP-2 siRNA induced Fas/CD95-mediated extrinsic II apoptotic pathway in the A549 lung adenocarcinoma cell line.
Modeling rates of infection with transient maternal antibodies and waning active immunity: application to Bordetella pertussis in Sweden.
Modulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress.
Modulation of Bordetella pertussis infection with monoclonal antibodies to pertussis toxin.
Monoclonal antibody against pertussis toxin: effect on toxin activity and pertussis infections.
Murine Coronavirus Infection Activates the Aryl Hydrocarbon Receptor in an Indoleamine 2,3-Dioxygenase-Independent Manner, Contributing to Cytokine Modulation and Proviral TCDD-Inducible-PARP Expression.
Neutralizing antibodies to pertussis toxin in whooping cough.
New Insights into the Significance of PARP-1 Activation: Flow Cytometric Detection of Poly(ADP-Ribose) as a Marker of Bovine Intramammary Infection.
Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin.
No associations of polymorphisms in ADPRT with hepatitis B virus clearance and hepatocellular carcinoma occurrence in a Korean population.
NSm protein of Rift Valley fever virus suppresses virus-induced apoptosis.
Nuclear Translocation of NF-{kappa}B Precedes Apoptotic Poly(ADP-ribose) Polymerase Cleavage during Productive HSV-1 Replication in Corneal Epithelial Cells.
Parenteral immunization of mice with a genetically inactivated pertussis toxin DNA vaccine induces cell-mediated immunity and protection.
Parents of ataxia-telangiectasia patients display a distinct cellular immune phenotype mimicking ATM mutated patients.
PARP inhibitor olaparib increases the oncolytic activity of dl922-947 in in vitro and in vivo model of anaplastic thyroid carcinoma.
PARP-1 controls NK cell recruitment to the site of viral infection.
PARP-1 Val762Ala polymorphism, CagA(+) H. pylori infection and risk for gastric cancer in Han Chinese population.
PARP1 Enhances Influenza A Virus Propagation by Facilitating Degradation of Host Type I Interferon Receptor.
PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy.
PARP1 Polymorphisms Increase the Risk of Gastric Cancer in a Chinese Population.
PARP1: A potential biomarker for gastric cancer.
Parthanatos-associated proteins are stimulated intraocularly during development of experimental murine cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression.
Pertussis Leukocytosis: Mechanisms, Clinical Relevance and Treatment.
Pertussis seroepidemiology in women and their infants in Sarlahi District, Nepal.
Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract.
Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis.
Pertussis toxin and its binding unit inhibit HIV-1 infection of human cervical tissue and macrophages involving a CD14 pathway.
Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection.
Pertussis toxin IgA testing over-diagnoses recent pertussis infection.
Pertussis toxin inhibits early chemokine production to delay neutrophil recruitment in response to Bordetella pertussis respiratory tract infection in mice.
Pertussis toxin permeabilization enhances the traversal of Escherichia coli K1, macrophages, and monocytes in a cerebral endothelial barrier model in vitro.
Pertussis toxin plays an early role in respiratory tract colonization by Bordetella pertussis.
Pertussis toxin promotes pulmonary hypertension in an infant mouse model of Bordetella pertussis infection.
Pertussis toxin sensitization alters the pathogenesis of subsequent respiratory syncytial virus infection.
Pertussis toxin stimulates IL-17 production in response to Bordetella pertussis infection in mice.
Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract.
Phenotypic comparison of Pseudomonas aeruginosa strains isolated from a variety of clinical sites.
Phosphoprotein Gene Contributes to the Enhanced Apoptosis Induced by Wild-Type Rabies Virus GD-SH-01 In Vitro.
Poly (ADP-ribose) polymerase-1 silences retroviruses independently of viral DNA integration or heterochromatin formation.
Poly(ADP-ribose) polymerase 1 is not strictly required for infection of murine cells by retroviruses.
Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses.
Poly(ADP-ribose) polymerase activity in various U937 cell subclones with different susceptibility to HIV-1 infection: its dramatic decrease following persistent virus infection.
Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration.
Poly(ADP-ribose)polymerase activity is reduced in circulating mononuclear cells from type 2 diabetic patients.
Poly(ADP-ribose)polymerase inhibition - where now?
Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase.
Polymorphism in the pertussis toxin promoter region affecting the DNA-based diagnosis of Bordetella infection.
Porcine parvovirus infection activates mitochondria-mediated apoptotic signaling pathway by inducing ROS accumulation.
Porcine reproductive and respiratory syndrome virus infection induces endoplasmic reticulum stress, facilitates virus replication, and contributes to autophagy and apoptosis.
Potent antitumor efficacy of XAF1 delivered by conditionally replicative adenovirus vector via caspase-independent apoptosis.
Prevalence, diagnosis, and disease course of pertussis in adults with acute cough: a prospective, observational study in primary care.
Production of exoenzyme S during Pseudomonas aeruginosa infections of burned mice.
Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections.
Prognostic Performance of Peripheral Blood Biomarkers in Identifying Seropositive Individuals at Risk of Developing Clinically Symptomatic Chagas Cardiomyopathy.
Proliferative responses and gamma interferon and tumor necrosis factor production by lymphocytes isolated from tracheobroncheal lymph nodes and spleen of mice aerosol infected with Bordetella pertussis.
Pseudomonas aeruginosa exoenzyme S stimulates murine lymphocyte proliferation in vitro.
Pseudomonas aeruginosa strains obtained from patients with tracheal, urinary tract and wound infection: variations in virulence factors and virulence genes.
Rac1, RhoA, and Cdc42 participate in HeLa cell invasion by group B streptococcus.
Recombinant oncolytic Newcastle disease virus displays antitumor activities in anaplastic thyroid cancer cells.
Repurposing of antiparasitic niclosamide to inhibit respiratory syncytial virus (RSV) replication.
Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway.
RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells.
RIG-I enhanced interferon independent apoptosis upon Junin virus infection.
Role of ADP-ribosyltransferase activity of pertussis toxin in toxin-adhesin redundancy with filamentous hemagglutinin during Bordetella pertussis infection.
Role of exoenzyme S in chronic Pseudomonas aeruginosa lung infections.
Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis.
Role of neutrophils in response to Bordetella pertussis infection in mice.
Role of pertussis toxin in causing symptoms of Bordetella parapertussis infection.
Role of Pseudomonas aeruginosa extracellular enzymes in lung disease.
Role of the adrenal medulla in stress-induced hyperinsulinaemia in normal mice and in mice infected with Bordetella pertussis or treated with pertussis toxin.
Schistosoma mansoni eggs induce Wnt/?-catenin signaling and activate the protooncogene c-Jun in human and hamster colon.
Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats.
Sero-epidemiology of Bordetella pertussis in England and Wales.
Seroepidemiology of diphtheria and pertussis in Chongqing, China: serology-based evidence of Bordetella pertussis infection.
Seroepidemiology of whooping cough in the Czech Republic: estimates of incidence of infection in adults.
Seroprevalence of Bordetella pertussis infection during pregnancy measured by IgG antibodies against pertussis toxin.
Seroprevalence of IgG antibodies to pertussis toxin in children and adolescents in Estonia.
Seroprevalence of pertussis in The Netherlands: evidence for increased circulation of Bordetella pertussis.
Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia.
Serum antibody response to B. pertussis Tn5 mutants, purified PT and FHA in two different mouse strains and passive protection in the murine intranasal infection model.
Serum IgG, IgA, and IgM responses to pertussis toxin, filamentous hemagglutinin, and agglutinogens 2 and 3 after infection with Bordetella pertussis and immunization with whole-cell pertussis vaccine.
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity.
Simian virus 40 infection triggers a balanced network that includes apoptotic, survival, and stress pathways.
Specificity and sensitivity of high levels of immunoglobulin G antibodies against pertussis toxin in a single serum sample for diagnosis of infection with Bordetella pertussis.
Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells.
Stimulus-response coupling in monocytes infected with Leishmania. Attenuation of calcium transients is related to defective agonist-induced accumulation of inositol phosphates.
Structural relationship between the S1 and S4 subunits of pertussis toxin.
Structure-activity relationships for inhibitors of Pseudomonas aeruginosa exoenzyme S ADP-ribosyltransferase activity.
Subclass compositions of immunoglobulin G to pertussis toxin in patients with whooping cough, in healthy individuals, and in recipients of a pertussis toxoid vaccine.
Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein.
Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells.
The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins.
The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity.
The effect of investigator compliance (observer bias) on calculated efficacy in a pertussis vaccine trial.
The efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in a respiratory mouse model.
The efficiency of R5 HIV-1 infection is determined by CD4 T-cell surface CCR5 density through G alpha i-protein signalling.
The growth of arthralgic Ross River virus is restricted in human monocytic cells.
The incidence of Bordetella pertussis infections estimated in the population from a combination of serological surveys.
The JAK/STAT3 signaling pathway mediates inhibition of host cell apoptosis by Chlamydia psittaci infection.
The role of exoenzyme S in infections with Pseudomonas aeruginosa.
The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia.
The seroepidemiology of Bordetella pertussis in Israel--Estimate of incidence of infection.
The seroepidemiology of Bordetella pertussis infection in Western Europe.
The seroepidemiology of pertussis in NSW: fluctuating immunity profiles related to changes in vaccination schedules.
Toxoplasma gondii triggers Gi-dependent PI 3-kinase signaling required for inhibition of host cell apoptosis.
TRAIL enhances apoptosis of human hepatocellular carcinoma cells sensitized by hepatitis C virus infection: therapeutic implications.
Transient inhibition of poly(ADP-ribose) polymerase expression and activity by Toxoplasma gondii is dispensable for parasite-mediated blockade of host cell apoptosis and intracellular parasite replication.
Trends in Hospital Admissions for Pertussis Infection: A Nationwide Retrospective Observational Study in Italy, 2002-2016.
Trypanosoma cruzi Induces the PARP1/AP-1 Pathway for Upregulation of Metalloproteinases and Transforming Growth Factor ? in Macrophages: Role in Cardiac Fibroblast Differentiation and Fibrosis in Chagas Disease.
Tula hantavirus infection of Vero E6 cells induces apoptosis involving caspase 8 activation.
Tumor suppressor in lung cancer-1 (TSLC1) mediated by dual-regulated oncolytic adenovirus exerts specific antitumor actions in a mouse model.
Tumor suppressor XAF1 induces apoptosis, inhibits angiogenesis and inhibits tumor growth in hepatocellular carcinoma.
Two-Component Cluster Analysis of a Large Serodiagnostic Database for Specificity of Increases of IgG Antibodies against Pertussis Toxin in Paired Serum Samples and of Absolute Values in Single Serum Samples.
U20 Is Responsible for Human Herpesvirus 6B Inhibition of TNF Receptor-Dependent Signaling and Apoptosis.
Use of chemokine receptors by poxviruses.
Use of transposon mutants to assess the role of exoenzyme S in chronic pulmonary disease due to Pseudomonas aeruginosa.
Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.
Western blot analysis of antibody responses of young infants to pertussis infection.
Widespread silent transmission of pertussis in families: antibody correlates of infection and symptomatology.
[A field survey carried out on the confirmation of a pertussis case in a village of Kirikkale Province, Turkey]
[Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. I. Antibody level for B pertussis antigens in children without respiratory tract infection symptoms]
[Preliminary results in the use of a new composite prosthesis in incisional hernia repair]
[Progress of nicotinamide in preventing infection and sepsis].
[Synergistic Effect of NF-?B Signaling Pathway Inhibitor and Oncolytic ?Measles Virus Vaccine Strain against Lung Cancer and Underlying Mechanisms].
[The frequency of detection of IgA, IgG and IgM antibodies to pertussis toxin in patients with respiratory tract infections in Poland]
Infertility
Disruption of Poly(ADP-Ribose) Homeostasis Affects Spermiogenesis and Sperm Chromatin Integrity in Mice.
Doxorubicin-induced testicular damage is related to PARP-1 signaling molecules in mice.
Infertility, Male
Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia.
Role of poly(ADP-ribose) polymerases in male reproduction.
Spermatid Head Elongation with Normal Nuclear Shaping Requires ADP-Ribosyltransferase PARP11 (ARTD11) in Mice.
Inflammatory Bowel Diseases
Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis.
GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat.
Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis.
Inflammatory Breast Neoplasms
PARP1 Inhibition Radiosensitizes Models of Inflammatory Breast Cancer to Ionizing Radiation.
Influenza in Birds
Biochemical Variations in Cytolytic Activity of Ortho- and Paramyxoviruses in Human Lung Tumor Cell Culture.
Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase.
Influenza, Human
ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase ?-TrCP.
Apoptosis and microglial activation in influenza encephalopathy.
Battle between influenza A virus and a newly identified antiviral activity of the PARP-containing ZAPL protein.
Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity.
Enhancing effects of pertussis toxin B oligomer on the immunogenicity of influenza vaccine administered intranasally.
PARP1 Enhances Influenza A Virus Propagation by Facilitating Degradation of Host Type I Interferon Receptor.
Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase.
Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers.
The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1.
Insulin Resistance
Effect of NAD on PARP-mediated insulin sensitivity in oleic acid treated hepatocytes.
Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance.
Oxidative Stress in Young Zucker Rats with Impaired Glucose Tolerance is Diminished by Acarbose.
Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis.
PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis.
PARP-1 DEFICIENCY EXACERBATES DIET-INDUCED OBESITY IN MICE.
Insulinoma
Effects of alpha 2-adrenergic agonism, imidazolines, and G-protein on insulin secretion in beta cells.
Increased susceptibility to streptozotocin-induced beta-cell apoptosis and delayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice.
Liquiritigenin prevents palmitate-induced beta-cell apoptosis via estrogen receptor-mediated AKT activation.
Poly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA.
Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP.
Role of JNK activation in pancreatic beta-cell death by streptozotocin.
Somatostatin activates glibenclamide-sensitive and ATP-regulated K+ channels in insulinoma cells via a G-protein.
Intervertebral Disc Degeneration
Tension induces intervertebral disc degeneration via endoplasmic reticulum stress-mediated autophagy.
Intestinal Polyposis
Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.
Iron Overload
Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload.
Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors.
Ischemic Attack, Transient
Effect of transient focal ischemia of mouse brain on energy state and NAD levels: no evidence that NAD depletion plays a major role in secondary disturbances of energy metabolism.
Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.
Role of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia.
Ischemic Stroke
Anti-inflammatory mechanism of taurine against ischemic stroke is related to down-regulation of PARP and NF-?B.
Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats.
Chromosomal damage and micronucleus induction by MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor: Evidence for a non-DNA-reactive mode of action.
Climbing STAIRs towards clinical trials with a novel PARP-1 inhibitor for the treatment of ischemic stroke.
Combined therapy with PJ34, a poly(ADP-ribose)polymerase inhibitor, reduces tissue plasminogen activator-induced hemorrhagic transformations in cerebral ischemia in mice.
Delayed PARP-1 Inhibition Alleviates Post-stroke Inflammation in Male Versus Female Mice: Differences and Similarities.
Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke.
Effect of 3-aminobenzamide, PARP inhibitor, on matrix metalloproteinase-9 level in plasma and brain of ischemic stroke model.
Emerging role of PARP-1 and PARthanatos in ischemic stroke.
Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia.
First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of a Neuroprotective Poly (ADP-ribose) Polymerase-1 Inhibitor, JPI-289, in Healthy Volunteers.
Ginsenoside Rd blocks AIF mitochondrio-nuclear translocation and NF-?B nuclear accumulation by inhibiting poly(ADP-ribose) polymerase-1 after focal cerebral ischemia in rats.
Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury.
MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model.
Neuroprotective effects of a novel Poly (ADP-Ribose) Polymerase-1 inhibitor, JPI-289, in hypoxic rat cortical neurons.
Neuroprotective effects of ONO-1924H, an inhibitor of poly ADP-ribose polymerase (PARP), on cytotoxicity of PC12 cells and ischemic cerebral damage.
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.
Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke.
Pertussis Toxin Ameliorates Microglial Activation Associated With Ischemic Stroke.
Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model.
Pertussis toxin-induced inflammatory response exacerbates intracerebral haemorrhage and ischaemic stroke in mice.
Poly(ADP-ribose) polymerase is not involved in the neuroprotection exerted by azithromycin against ischemic stroke in mice.
Polymorphism of PARP-1 indicates an increased risk and a worse initial severity of ischemic stroke.
Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia.
Regulatory T cells increase after treatment with poly (ADP-ribose) polymerase-1 inhibitor in ischemic stroke patients.
Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis.
The early immunological response to acute ischemic stroke: Differential gene expression in subpopulations of mononuclear cells.
The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals.
[Gender-specific factors of ischemic stroke among atrial fibrillation patients].
[The epidemiological characteristics and adherence to hypoglycemic agents of ischemic stroke patients with diabetes].
Joint Instability
Genotype-phenotype relationship in a child with 2.3 Mb de novo interstitial 12p13.33-p13.32 deletion.
Keloid
A Selenium-Enriched Ziyang Green Tea Polysaccharide Induces Bax-Dependent Mitochondrial Apoptosis and Inhibits TGF-?1-Stimulated Collagen Expression in Human Keloid Fibroblasts via NG2 Inactivation.
PARP1 Inhibition as a Novel Therapeutic Target for Keloid Disease.
Ketosis
Pertussis toxin induces fatty liver, hyperlipemia and ketosis in hamsters.
Kidney Diseases
Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model.
Kidney Failure, Chronic
Accumulation of plasma N-methyl-2-pyridone-5-carboxamide in patients with chronic renal failure.
Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure.
PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis.
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2.
Kidney Neoplasms
Development of flexible-heteroarotinoids for kidney cancer.
Folliculin deficient renal cancer cells exhibit BRCA1 A complex expression impairment and sensitivity to PARP1 inhibitor olaparib.
Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers.
Histone-dependent PARP-1 inhibitors: A novel therapeutic modality for the treatment of prostate and renal cancers.
Long noncoding RNA PVT1 inhibits renal cancer cell apoptosis by up-regulating Mcl-1.
MIR494 reduces renal cancer cell survival coinciding with increased lipid droplets and mitochondrial changes.
Penta-O-galloyl-?-D-glucose attenuates cisplatin-induced nephrotoxicity via reactive oxygen species reduction in renal epithelial cells and enhances antitumor activity in Caki-2 renal cancer cells.
Labyrinth Diseases
High dose combination pertussis toxin induces autoimmune inner ear disease in Sprague-Dawley rats.
Laryngeal Neoplasms
Reduced poly(ADP-ribosyl)ation in lymphocytes of laryngeal cancer patients: results of a case-control study.
[Apoptosis mechanism of taxol combined with resveratrol on human laryngeal carcinoma Hep-2 cells].
Leg Ulcer
Redox Profiling Reveals Clear Differences between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds.
Leiomyoma
Enhanced polyadenosine diphosphate-ribosylation in gonadotropin-releasing hormone agonist-treated uterine leiomyoma.
Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells.
Selective progesterone receptor modulator asoprisnil induces endoplasmic reticulum stress in cultured human uterine leiomyoma cells.
Leiomyosarcoma
Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing.
Homologous recombination repair deficiency as a therapeutic target in sarcoma.
Novel approaches to treatment of leiomyosarcomas.
Leishmaniasis
Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonensis promastigotes.
Leprosy
Effect of inhibitor of poly (ADP-ribose) polymerase in blood lymphocyte cultures of untreated leprosy patients.
Leukemia
A novel synthesized 3', 5'-diprenylated chalcone mediates the proliferation of human leukemia cells by regulating apoptosis and autophagy pathways.
A Phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms and chronic myelomonocytic leukemia.
A Regulatory Role for RUNX1, RUNX3 in the Maintenance of Genomic Integrity.
A112, a tamibarotene dimethylaminoethyl ester, may inhibit human leukemia cell growth more potently than tamibarotene.
Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa.
ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line.
Anticancer activity of a synthetic peptide derived from harmoniasin, an antibacterial peptide from the ladybug Harmonia axyridis.
Apoptosis and perturbation of cell cycle progression in an acidic environment after hyperthermia.
Apoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin.
Apoptotic Effect of Galbanic Acid via Activation of Caspases and Inhibition of Mcl-1 in H460 Non-Small Lung Carcinoma Cells.
Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappaB survival pathway signaling.
Augmentation of tumor necrosis factor-alpha-induced monocytic differentiation of a myelomonocytic leukemia (WEHI-3B JCS) by pertussis toxin.
Auraptene Induces Apoptosis via Myeloid Cell Leukemia 1-Mediated Activation of Caspases in PC3 and DU145 Prostate Cancer Cells.
beta-Lapachone (LAPA) Decreases Cell Viability and Telomerase Activity in Leukemia Cells: Suppression of Telomerase Activity by LAPA.
Biochemical pathways of apoptosis: nicotinamide adenine dinucleotide-deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-kD apoptotic protease and DNA fragmentation.
BRCA1 deficiency and synthetic lethality in leukemias; not only gene mutation matters.
Breaking chemoresistance and radioresistance with [213Bi]anti-CD45 antibodies in leukemia cells.
c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias.
Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells.
Cellular and biochemical antileukemic mechanisms of the meroterpenoid Oncocalyxone A.
Characterization of antibodies specific for the caspase cleavage site on poly(ADP-ribose) polymerase: specific detection of apoptotic fragments and mapping of the necrotic fragments of poly(ADP-ribose) polymerase.
Characterization of increased K+ permeability associated with the stimulation of receptors for immunoglobulin E on rat basophilic leukemia cells.
Cladribine in combination with entinostat synergistically elicits anti-proliferative/anti-survival effects on multiple myeloma cells.
Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells.
Combination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide-resistant cancer cells.
Combinatorial Effects of PARP Inhibitor PJ34 and Histone Deacetylase Inhibitor Vorinostat on Leukemia Cell Lines.
Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage.
Cytotoxic components from the leaves of Erythrophleum fordii induce human acute leukemia cell apoptosis through caspase 3 activation and PARP cleavage.
Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways.
Cytotoxicity of Gymnopilus purpureosquamulosus extracts on hematologic malignant cells through activation of the SAPK/JNK signaling pathway.
Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells.
Differential responses of proliferative and non-proliferative leukemia cells to oxidative stress.
Down-modulation of poly(ADP-ribose) polymerase-1 (PARP-1) in human TUR leukemia cells restores transcriptional responsiveness for differentiation and cell cycle arrest.
Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro.
Effect of Notch and PARP Pathways' Inhibition in Leukemic Cells.
Eltrombopag modulates reactive oxygen species and decreases acute myeloid leukemia cell survival.
Epicochalasines?A and B: Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes.
Eupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway.
Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells.
Histamine receptor-dependent and/or -independent activation of guanine nucleotide-binding proteins by histamine and 2-substituted histamine derivatives in human leukemia (HL-60) and human erythroleukemia (HEL) cells.
Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin.
Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii.
Induction of G2/M phase arrest and apoptosis of human leukemia cells by potent antitumor triazoloacridinone C-1305.
Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status.
Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene.
Inhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death.
Inhibition of the mutated c-KIT kinase in AML1-ETO-positive leukemia cells restores sensitivity to PARP inhibitor.
Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells.
Interactive effects of histone deacetylase inhibitors and TRAIL on apoptosis in human leukemia cells: involvement of both death receptor and mitochondrial pathways.
Loperamide, an antidiarrheal agent, induces apoptosis and DNA damage in leukemia cells.
Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al.
Methadone, commonly used as maintenance medication for outpatient treatment of opioid dependence, kills leukemia cells and overcomes chemoresistance.
Methylene chloride fraction of Scutellaria barbata induces apoptosis in human U937 leukemia cells via the mitochondrial signaling pathway.
MiR-181a enhances drug sensitivity of mixed lineage leukemia-rearranged acute myeloid leukemia by increasing poly(ADP-ribose) polymerase1 acetylation.
MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs.
Modeling and targeting of erythroleukemia by hematopoietic genome editing.
Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia.
Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia.
Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.
Oleanolic Acid Induces Apoptosis in Human Leukemia Cells through Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage.
Overexpression of poly(ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells.
Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway.
PARP goes the weasel! Emerging role of PARP inhibitors in acute leukemias.
PARP inhibitor re?sensitizes Adriamycin resistant leukemia cells through DNA damage and apoptosis.
PARP Inhibitors as Therapeutic Options for Tyrosine Kinase-dependent Leukemia: A Review.
PARP Inhibitors Suppress AML1-ETO- and PML-RAR?-Positive Leukemia.
PARP-1 (Poly[ADP-Ribose] Polymerase 1) Inhibition Protects From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm in Mice.
Peroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells.
Pertussis toxin inhibits activation-induced cell death of human thymocytes, pre-B leukemia cells and monocytes.
Pertussis toxin inhibits differentiation induced by retinoic acid in a human promyelocytic leukemia cell line HL-60.
Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids.
Pertussis toxin selectively interferes with the responses of the HL-60 human promyelocytic cell line to dimethylsulfoxide.
Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells.
Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses.
Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity.
Poly(ADP-Ribose) Polymerase Inhibitors for Arsenic Trioxide-Resistant Acute Promyelocytic Leukemia: Synergistic In Vitro Antitumor Effects with Hypomethylating Agents or High-Dose Vitamin C.
Purging effect of dibutyl phthalate on leukemia cells involves fas independent activation of caspase-3/CPP32 protease.
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) exert their anti-proliferative activity by interfering with Akt-mTOR signaling and bax:bcl-2 ratio modulation in cells from chronic myeloid leukemic patients.
Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells.
Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt.
Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways.
Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia.
Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells.
Sequence-specific binding of poly(ADP-ribose) polymerase-1 to the human T cell leukemia virus type-I tax responsive element.
Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response.
Synergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase.
Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells.
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines.
Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors.
Tanshinone IIA Induces Autophagic Cell Death via Activation of AMPK and ERK and Inhibition of mTOR and p70 S6K in KBM-5 Leukemia Cells.
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
The combination of the PARP inhibitor rucaparib and 5FU is an effective strategy for treating acute leukemias.
The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors.
The interleukin 1beta-converting enzyme inhibitor CrmA prevents Apo1/Fas- but not glucocorticoid-induced poly(ADP-ribose) polymerase cleavage and apoptosis in lymphoblastic leukemia cells.
The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction.
The Natural Antiangiogenic Compound AD0157 Induces Caspase-Dependent Apoptosis in Human Myeloid Leukemia Cells.
To PARP or not to PARP?-Toward sensitizing acute myeloid leukemia stem cells to immunotherapy.
Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors.
WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells.
Zephycandidine A, the First Naturally Occurring Imidazo[1,2-f]phenanthridine Alkaloid from Zephyranthes candida, Exhibits Significant Anti-tumor and Anti-acetylcholinesterase Activities.
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis.
[Gene Expression Profile of Apoptosis in Leukemia Cells Induced by Hsp90 Selective inhibitor 17-AAG].
Leukemia, Erythroblastic, Acute
A novel synthesized 3', 5'-diprenylated chalcone mediates the proliferation of human leukemia cells by regulating apoptosis and autophagy pathways.
Berberis libanotica extract targets NF-?B/COX-2, PI3K/Akt and mitochondrial/caspase signalling to induce human erythroleukemia cell apoptosis.
Induction of erythroid differentiation of murine erythroleukemia cells by nicotinamide and related compounds.
Mitosis may be an obligatory route to terminal differentiation in the Friend erythroleukemia cell.
Leukemia, Hairy Cell
Cladribine in combination with entinostat synergistically elicits anti-proliferative/anti-survival effects on multiple myeloma cells.
Leukemia, Lymphocytic, Chronic, B-Cell
A subset of chronic lymphocytic leukemia patients display reduced levels of PARP1 expression coupled with a defective irradiation-induced apoptosis.
Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage.
Poly(ADP-ribose) polymerase can bind melphalan damaged DNA.
Poly(ADP-ribose) polymerase inhibitor CEP-8983 synergizes with bendamustine in chronic lymphocytic leukemia cells in vitro.
Role of nicotinamide adenine dinucleotide and adenosine triphosphate in glucocorticoid-induced cytotoxicity in susceptible lymphoid cells.
Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia.
Leukemia, Monocytic, Acute
PARP-1 (Poly[ADP-Ribose] Polymerase 1) Inhibition Protects From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm in Mice.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Apoptotic effects of some tetrahydronaphthalene derivatives on K562 human chronic myelogenous leukemia cell line.
c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias.
Hyaluronic Acid Inhibitor 4-Methylumbelliferone Activates the Intrinsic Apoptosis Pathway in K562 Chronic Myelogenous Leukemia Cells.
PARP1 inhibitor eliminated imatinib-refractory chronic myeloid leukemia cells in bone marrow microenvironment conditions.
Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression.
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) exert their anti-proliferative activity by interfering with Akt-mTOR signaling and bax:bcl-2 ratio modulation in cells from chronic myeloid leukemic patients.
Targeting autophagy potentiates the anti-tumor effect of PARP inhibitor in pediatric chronic myeloid leukemia.
Leukemia, Myeloid
Antinflammatory and anticancer effects of terpenes from oily fractions of Teucruim alopecurus, blocker of I?B? kinase, through downregulation of NF-?B activation, potentiation of apoptosis and suppression of NF-?B-regulated gene expression.
Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro.
Gi and Gq/11 proteins are involved in dissemination of myeloid leukemia cells to the liver and spleen, whereas bone marrow colonization involves Gq/11 but not Gi.
PARP1 Is Overexpressed in Hematological Malignant Cell Lines: A Framework for Experimental Oncology.
PK11195, an isoquinoline carboxamide ligand of the mitochondrial benzodiazepine receptor, increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro.
Poly(ADP-ribose) polymerase inhibitor-associated myelodysplastic syndrome/acute myeloid leukemia: a pharmacovigilance analysis of the FAERS database.
Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression.
TET2 Function in Hematopoietic Malignancies, Immune Regulation, and DNA Repair.
[Apoptosis of myeloid leukemia cell line HL60 induced by Bortezomib, a proteasome inhibitor]
Leukemia, Myeloid, Acute
A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia.
BRCA1, PARP1 and ?H2AX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparib.
Different regulation of PARP1, PARP2, PARP3 and TRPM2 genes expression in acute myeloid leukemia cells.
Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer.
High PARP-1 expression predicts poor survival in acute myeloid leukemia and PARP-1 inhibitor and SAHA-bendamustine hybrid inhibitor combination treatment synergistically enhances anti-tumor effects.
Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene.
Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes.
NF?B and Poly (ADP-ribose) Polymerase 1 Form a Positive Feedback Loop that Regulates DNA Repair in Acute Myeloid Leukemia Cells.
Olaparib for the treatment of epithelial ovarian cancer.
Omics Technologies to Decipher Regulatory Networks in Granulocytic Cell Differentiation.
PARP goes the weasel! Emerging role of PARP inhibitors in acute leukemias.
PARP Inhibitors Suppress AML1-ETO- and PML-RAR?-Positive Leukemia.
PARP-1 Overexpression as an Independent Prognostic Factor in Adult Non-M3 Acute Myeloid Leukemia.
PARP-inhibitor-induced synthetic lethality for acute myeloid leukemia treatment.
Partnering with PARP inhibitors in acute myeloid leukemia with FLT3-ITD.
Poly (ADP-ribose) polymerase-1 (PARP1) as a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.
PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes.
Regulation of the nuclear proteasome activity in myelomonocytic human leukemia cells after adriamycin treatment.
Synergistic Cytotoxic Effect of Busulfan and the PARP Inhibitor Veliparib in Myeloproliferative Neoplasms.
The Association between PARP1 and LIG3 Expression Levels and Chromosomal Translocations in Acute Myeloid Leukemia Patients.
The poly (ADP ribose) polymerase inhibitor niraparib: Management of toxicities.
The poly(ADP-ribose) polymerase inhibitor olaparib induces up-regulation of death receptors in primary acute myeloid leukemia blasts by NF-?B activation.
The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance.
To PARP or not to PARP?-Toward sensitizing acute myeloid leukemia stem cells to immunotherapy.
Leukemia, Myelomonocytic, Chronic
A Phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms and chronic myelomonocytic leukemia.
Leukemia, Promyelocytic, Acute
Overexpression of poly(ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells.
Poly(ADP-Ribose) Polymerase Inhibitors for Arsenic Trioxide-Resistant Acute Promyelocytic Leukemia: Synergistic In Vitro Antitumor Effects with Hypomethylating Agents or High-Dose Vitamin C.
Leukemia, T-Cell
Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells.
Identification of poly(ADP-ribose) polymerase as a transcriptional coactivator of the human T-cell leukemia virus type 1 Tax protein.
Sequence-specific binding of poly(ADP-ribose) polymerase-1 to the human T cell leukemia virus type-I tax responsive element.
Leukemia-Lymphoma, Adult T-Cell
Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells.
Leukocytosis
A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough.
Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin.
Collaborative study on test systems to assess toxicity of whole cell pertussis vaccine.
Effect of pertussis toxin on susceptibility of infant rats to Haemophilus influenzae type b.
Immune response to the B oligomer of pertussis toxin.
Neutralization of pertussis toxin by a single antibody prevents clinical pertussis in neonatal baboons.
Pertussis Leukocytosis: Mechanisms, Clinical Relevance and Treatment.
Pertussis toxin treatment in vivo reduces surface expression of the adhesion integrin leukocyte function antigen-1 (LFA-1).
Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying.
The prevention of severe pertussis and pertussis deaths in young infants.
The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines.
Leukoencephalopathies
Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia.
PARP-1 deregulation in multiple sclerosis.
Leukoencephalopathy, Progressive Multifocal
PARP-1 deregulation in multiple sclerosis.
Leukopenia
Pertussis toxin induces bronchopulmonary hyperresponsiveness in guinea-pigs while antagonizing the effects of formyl-L-methionyl-L-leucyl-L-phenylalanine.
Leukoplakia
Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis?
Leukostasis
Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms.
Peroxynitrite decomposition catalyst, FP15, and poly(ADP-ribose) polymerase inhibitor, PJ34, inhibit leukocyte entrapment in the retinal microcirculation of diabetic rats.
Lewy Body Disease
The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease.
Li-Fraumeni Syndrome
DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.
Lipid Metabolism Disorders
Inhibition of Poly(ADP-Ribose) Polymerase Increased Lipid Accumulation Through SREBP1 Modulation.
Liposarcoma
Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas.
Growth inhibitory effect of quercetin on SW 872 human liposarcoma cells.
Liver Cirrhosis
Baicalin Ameliorates Experimental Liver Cholestasis in Mice by Modulation of Oxidative Stress, Inflammation, and NRF2 Transcription Factor.
Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis.
Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition.
Liver Diseases
Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid.
Metabolic roles of poly(ADP-ribose) polymerases.
Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease.
PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.
PARPs in lipid metabolism and related diseases.
Poly (ADP?ribose) polymerase? and cytochrome c?mediated apoptosis induces hepatocyte injury in a rat model of hyperammonia?induced hepatic failure.
Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
The impact of the phytotherapeutic agent quercetin on expression of genes and activity of signaling pathways.
Liver Diseases, Alcoholic
PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.
Liver Failure
Cytosolic phospholipase A(2)? protects against Fas- but not LPS-induced liver injury.
Liver Neoplasms
A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.
Anticancer effect of xanthohumol induces growth inhibition and apoptosis of human liver cancer through NF-?B/p53-apoptosis signaling pathway.
Autoimmune response to PARP and BRCA1/BRCA2 in cancer.
Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression.
Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells.
Combination PARP and HDAC inhibition as a therapeutic strategy targeting liver cancer stem cells?
Comparison of the Phytochemical Properties, Antioxidant Activity and Cytotoxic Effect on HepG2 Cells in Mongolian and Taiwanese Rhubarb Species.
Direct measurement of protein-protein interactions by FLIM-FRET at UV laser-induced DNA damage sites in living cells.
Disulfiram combined with copper induces immunosuppression via PD-L1 stabilization in hepatocellular carcinoma.
Expression of cluster of differentiation-95 and relevant signaling molecules in liver cancer.
Inhibited effects of veliparib combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line.
Inhibition of poly (ADP-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells.
Interference of Mucin 1 inhibits the growth of liver cancer cells by inducing mitochondria-mediated and death receptor-mediated cell apoptosis.
Male rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity.
PARP inhibition and the radiosensitizing effects of the PARP inhibitor ABT-888 in in vitro hepatocellular carcinoma models.
PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells.
Repressing of NHERF1 inhibits liver cancer progression by promoting the production of ROS.
Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells.
Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation.
Synergistic suppressive effect of PARP-1 inhibitor PJ34 and HDAC inhibitor SAHA on proliferation of liver cancer cells.
The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment.
Veliparib overcomes multidrug resistance in liver cancer cells.
[Overexpression of protein phosphatase 2 regulatory subunit B''? gene effect on proliferation and invasion of hepatoma cells].
Long QT Syndrome
PARP inhibitor-induced torsades de pointes in long QT syndrome: a case report.
Lung Diseases
Poly(ADP-ribosyl)ation in asthma and other lung diseases.
Ubiquitin-Specific Protease 14 (USP14) Aggravates Inflammatory Response and Apoptosis of Lung Epithelial Cells in Pneumonia by Modulating Poly (ADP-Ribose) Polymerase-1 (PARP-1).
Use of transposon mutants to assess the role of exoenzyme S in chronic pulmonary disease due to Pseudomonas aeruginosa.
Lung Diseases, Interstitial
[Interstitial Pneumonia Caused by Olaparib during Treatment of Breast Cancer-A Case Report].
Lung Injury
Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis.
Alteration of pulmonary structure by Pseudomonas aeruginosa exoenzyme S.
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury.
Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase.
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide.
Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats.
Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury.
Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury.
INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation.
Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib ameliorates influenza-virus-induced pneumonia in mice.
Poly(ADP-ribose) polymerase-1 (PARP-1) controls lung cell proliferation and repair after hyperoxia-induced lung damage.
Poly-ADP-ribose polymerase inhibition provides protection against lung injury in a rat paraquat toxicity model.
Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes.
Prolonged poly(ADP-ribose) polymerase-1 activity regulates JP-8-induced sustained cytokine expression in alveolar macrophages.
Protective effect of orally administered carnosine on bleomycin-induced lung injury.
Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice.
Pulmonary and renal protection: targeting PARP to ventilator-induced lung and kidney injury?
Renal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP pathway.
Role of PARP on iNOS pathway during endotoxin-induced acute lung injury.
Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass.
Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury.
Treatment with 3-aminobenzamide during ex vivo lung perfusion of damaged rat lungs reduces graft injury and dysfunction after transplantation.
[Acute poisoning by chemical warfare agent: sulfur mustard]
Lung Neoplasms
?-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells.
A Dose-finding Study Followed by a Phase II Randomized, Placebo-controlled Trial of Chemoradiotherapy With or Without Veliparib in Stage III Non-small-cell Lung Cancer: SWOG 1206 (8811).
A genetic snapshot of small cell lung cancer.
A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors.
A randomized Phase II study of veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in BRCA1/2 metastatic breast cancer: design and rationale.
A Small Compound KJ-28d Enhances the Sensitivity of Non-Small Cell Lung Cancer to Radio- and Chemotherapy.
A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures.
Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity.
Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy.
Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer.
Adenosine diphosphate ribosyl transferase responses to a standardized dose of hydrogen peroxide in the mononuclear leukocytes of patients with a diagnosis of cancer.
Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth.
Altered expression profile of apoptosis-related molecules correlated with clinicopathological factors in non-small-cell lung cancer.
An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer.
Anticarcinogenic effects of halofuginone on lung-derived cancer cells.
Antitumor effect of BPR-DC-2, a novel synthetic cyclic cyanoguanidine derivative, involving the inhibition of MDR-1 expression and down-regulation of p-AKT and PARP-1 in lung cancer.
APR-246 (PRIMA-1(MET)) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines.
Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes.
Association of T2285C polymorphism in PARP1 gene coding region with its expression, activity and NSCLC risk along with prognosis.
Autoimmune response to PARP and BRCA1/BRCA2 in cancer.
Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.
BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death.
Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis.
Biological evaluation of 2-arylidene-4, 7-dimethyl indan-1-one (FXY-1): a novel Akt inhibitor with potent activity in lung cancer.
Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.
Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells.
Characterization of a sulfated galactoglucan from Antrodia cinnamomea and its anticancer mechanism via TGF?/FAK/Slug axis suppression.
Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk.
Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small cell lung cancer.
Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer.
Correction to: The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer.
Correlation between PARP-1 Val762Ala polymorphism and the risk of lung cancer in a Chinese population.
CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis.
Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer.
DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.
Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair.
Drug Targeting of Genomic Instability in Multiple Myeloma.
Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer.
EGFR-Activating Mutations Correlate with a Fanconi Anemia-like Cellular Phenotype That Includes PARP Inhibitor Sensitivity.
Ethnic differences in poly(ADP-ribose) polymerase pseudogene genotype distribution and association with lung cancer risk.
Expression of ERCC1, MSH2 and PARP1 in non-small cell lung cancer and prognostic value in patients treated with platinum-based chemotherapy.
FLLL12 induces apoptosis in lung cancer cells through a p53/p73-independent but death receptor 5-dependent pathway.
Fluzoparib increases radiation sensitivity of non-small cell lung cancer (NSCLC) cells without BRCA1/2 mutation, a novel PARP1 inhibitor undergoing clinical trials.
Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC).
Fucoidan upregulates TLR4/CHOP-mediated caspase-3 and PARP activation to enhance cisplatin-induced cytotoxicity in human lung cancer cells.
Functional Polymorphisms of Base Excision Repair Genes XRCC1 and APEX1 Predict Risk of Radiation Pneumonitis in Patients with Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy.
H2AX a promising biomarker for lung cancer: a review.
Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.
Identification of amentoflavone as a potent highly selective PARP-1 inhibitor and its potentiation on carboplatin in human non-small cell lung cancer.
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Identifying new piperazine-based PARP1 inhibitors using text mining and integrated molecular modeling approaches.
Improved radiosynthesis of 123I-MAPi, an auger theranostic agent.
Inhibition of ELF3 confers synthetic lethality of PARP inhibitor in non-small cell lung cancer.
Inhibition of poly(ADP-ribose) polymerase (PARP) induces apoptosis in lung cancer cell lines.
Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models.
Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad.
JASPER: Phase 2 trial of first-line niraparib plus pembrolizumab in patients with advanced non-small cell lung cancer.
Kinesin light chain-4 depletion induces apoptosis of radioresistant cancer cells by mitochondrial dysfunction via calcium ion influx.
MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7.
Miltirone-induced apoptosis in cisplatin-resistant lung cancer cells through upregulation of p53 signaling pathways.
MiR-205 and miR-218 expression is associated with carboplatin chemoresistance and regulation of apoptosis via Mcl-1 and Survivin in lung cancer cells.
MiR-335 regulates the chemo-radioresistance of small cell lung cancer cells by targeting PARP-1.
MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer.
Molecular mechanism of Antrodia cinnamomea sulfated polysaccharide on the suppression of lung cancer cell growth and migration via induction of transforming growth factor ? receptor degradation.
MSH2/BRCA1 expression as a DNA-repair signature predicting survival in early-stage lung cancer patients from the IFCT-0002 Phase 3 Trial.
Nanoemulsion-Based Delivery of Fluorescent PARP Inhibitors in Mouse Models of Small Cell Lung Cancer.
Nanopharmaceutical Approach for Enhanced Anti-cancer Activity of Betulinic Acid in Lung-cancer Treatment via Activation of PARP: Interaction with DNA as a Target: -Anti-cancer Potential of Nano-betulinic Acid in Lung Cancer.
Negative prognostic value of high levels of intracellular poly(ADP-ribose) in non-small cell lung cancer.
New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules.
No association between haplotypes of three variants (codon 81, 284, and 762) in poly(ADP-ribose) polymerase gene and risk of primary lung cancer.
Non-small and small cell lung carcinoma cell lines exhibit cell type-specific sensitivity to edelfosine-induced cell death and different cell line-specific responses to edelfosine treatment.
Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors.
Novel targeted strategies to overcome resistance in small-cell lung cancer: focus on PARP inhibitors and rovalpituzumab tesirine.
NSCLC Mutated Isoforms of CCDC6 Affect the Intracellular Distribution of the Wild Type Protein Promoting Cisplatinum Resistance and PARP Inhibitors Sensitivity in Lung Cancer Cells.
Oncolytic newcastle disease virus triggers cell death of lung cancer spheroids and is enhanced by pharmacological inhibition of autophagy.
P-glycoprotein-independent apoptosis induction by a novel synthetic compound, MMPT [5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone].
PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer.
PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer.
PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells.
PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2.
PARP inhibitor activates the intrinsic pathway of apoptosis in primary lung cancer cells.
PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer.
PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.
PARP inhibitors for small cell lung cancer and their potential for integration into current treatment approaches.
PARP inhibitors in lung cancer.
PARP Inhibitors in Small-Cell Lung Cancer: Rational Combinations to Improve Responses.
PARP inhibitors synergize with gemcitabine by potentiating DNA damage in non-small-cell lung cancer.
PARP inhibitors: an interesting pathway also for Non-Small Cell Lung Cancer?
PARP Inhibitors: Extending Benefit Beyond BRCA Mutant Cancers.
PARP-1 induces EMT in non-small cell lung carcinoma cells via modulating the transcription factors Smad4, p65 and ZEB1.
PARP-1 rs3219073 polymorphism may contribute to susceptibility to lung cancer.
PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair.
PARP1 impact on DNA repair of platinum adducts: Preclinical and clinical read-outs.
PARP1 Inhibitors: antitumor drug design.
PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin.
Participation of poly(ADP-ribose) polymerase in the drug sensitivity in human lung cancer cell lines.
Pelargonium quercetorum Agnew induces apoptosis without PARP or cytokeratin 18 cleavage in non-small cell lung cancer cell lines.
Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non-Small Cell Lung Cancer.
Phosphorylation of the Cytoskeletal Protein CAP1 Regulates Non-Small Cell Lung Cancer Survival and Proliferation by GSK3?.
Photoluminescent And Self-Assembled Hyaluronic Acid-Zinc Oxide-Ginsenoside Rh2 Nanoparticles And Their Potential Caspase-9 Apoptotic Mechanism Towards Cancer Cell Lines.
Phoyunnanin E Induces Apoptosis of Non-small Cell Lung Cancer Cells via p53 Activation and Down-regulation of Survivin.
Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity.
Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression.
Poly(ADP-ribose) polymerase-1 regulates vimentin expression in lung cancer cells.
Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer.
Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer.
Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer.
Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1.
Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation.
Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L).
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Radiosynthesis of 3 H- and 14 C-labeled Veliparib.
Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer.
Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.
Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer.
Replication-dependent ?-H2AX formation is involved in docetaxel-induced apoptosis in NSCLC A549 cells.
Retraction Note to: Correlation between PARP-1 Val762Ala polymorphism and the risk of lung cancer in a Chinese population.
Revealing biomarkers associated with PARP inhibitors based on genetic interactions in cancer genome.
Silencing tankyrase and telomerase promotes A549 human lung adenocarcinoma cell apoptosis and inhibits proliferation.
Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non-Small Cell Lung Cancer: Methodological Issues.
Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non-Small Cell Lung Cancer.
Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells.
Suppression of NF-?B signaling and P-glycoprotein function by gambogic acid synergistically potentiates adriamycin -induced apoptosis in lung cancer.
Synergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase.
Synergistic effect of fenretinide and curcumin for treatment of non-small cell lung cancer.
Synergistic Effect of Olaparib with Combination of Cisplatin on PTEN-Deficient Lung Cancer Cells.
Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells.
Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer.
Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption.
Tankyrase 1 polymorphism associated with an increased risk in developing non-small cell lung cancer in a Chinese population: a proof-of-principle study.
Tankyrase 2 (TNKS2) polymorphism associated with risk in developing non-small cell lung cancer in a Chinese population.
Target engagement imaging of PARP inhibitors in small-cell lung cancer.
Temozolomide plus PARP Inhibition in Small-Cell Lung Cancer: Could Patient-Derived Xenografts Accelerate Discovery of Biomarker Candidates?
Tetrandrine suppresses lung cancer growth and induces apoptosis, potentially via the VEGF/HIF-1?/ICAM-1 signaling pathway.
The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer.
The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer.
The MYC Paralog-PARP1 Axis as a Potential Therapeutic Target in MYC Paralog-Activated Small Cell Lung Cancer.
The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors.
Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling.
Tumor suppressor in lung cancer-1 (TSLC1) mediated by dual-regulated oncolytic adenovirus exerts specific antitumor actions in a mouse model.
Uncovering synthetic lethal interactions for therapeutic targets and predictive markers in lung adenocarcinoma.
Unveiling the mechanistic roles of chlorine substituted phthalazinone-based compounds containing chlorophenyl moiety towards the differential inhibition of poly (ADP-ribose) polymerase-1 in the treatment of lung cancer.
Veliparib in Combination with Carboplatin and Etoposide in Patients with Treatment-Naïve Extensive-Stage Small Cell Lung Cancer: A Phase 2 Randomized Study.
Voies de réparation de l'ADN et cancers bronchiques non à petites cellules : perspectives cliniques.
WITHDRAWN: An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer.
XPO1 inhibition synergizes with PARP1 inhibition in small cell lung cancer by targeting nuclear transport of FOXO3a.
XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition.
[Distribution of poly(ADP-ribose) polymerase pseudogene polymorphism and association with susceptibility to lung cancer in Chinese people]
Lupus Erythematosus, Systemic
Altered autoantigen structure in Sjögren's syndrome: implications for the pathogenesis of autoimmune tissue damage.
Association of poly(ADP-ribose) polymerase 1 and a novel candidate locus, LOC127086, with systemic lupus erythematosus.
Autoantibodies reacting with poly(ADP-ribose) and with a zinc-finger functional domain of poly(ADP-ribose) polymerase involved in the recognition of damaged DNA.
Constitutive abnormal expression of RasGRP-1 isoforms and low expression of PARP-1 in patients with systemic lupus erythematosus.
Identification of autoantibody against poly (ADP-ribose) polymerase (PARP) fragment as a serological marker in systemic lupus erythematosus.
MiR-199-3p promotes ERK-mediated IL-10 production by targeting poly (ADP-ribose) Polymerase-1 in patients with systemic lupus erythematosus.
PARP activity and NAD concentration in PMC from patients affected by systemic sclerosis and lupus erythematosus.
PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus.
Poly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus.
Poly(ADP-ribose) polymerase activity in systemic lupus erythematosis and systemic sclerosis.
Poly(ADP-ribose) polymerase alleles in French Caucasians are associated neither with lupus nor with primary antiphospholipid syndrome. GRAID Research Group. Group for Research on Auto-Immune Disorders.
Poly(ADP-ribose) polymerase polymorphisms are not a genetic risk factor for systemic lupus erythematosus in German Caucasians.
Lymphangioleiomyomatosis
Rapamycin-resistant PARP1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis (LAM).
Lymphatic Metastasis
Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma.
Down-regulation of Notch receptor signaling pathway induces caspase-dependent and caspase-independent apoptosis in lung squamous cell carcinoma cells.
ERCC1, PARP-1, and AQP1 as predictive biomarkers in colon cancer patients receiving adjuvant chemotherapy.
High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer.
Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2.
PARP-1 may be involved in angiogenesis in epithelial ovarian cancer.
Lymphocytosis
A novel bivalent acellular pertussis vaccine based on the 69 kDa protein and FHA.
Antitoxin in human pertussis immune globulins.
Bacterial toxins affect early events of T lymphocyte activation.
Caffeine to prevent respiratory failure and improve outcome in infant pertussis.
Clinical reactions and immunogenicity of the BIKEN acellular diphtheria and tetanus toxoids and pertussis vaccine in 4- through 6-year-old US children.
Effects of dexamethasone and indomethacin on the vascular beta 2-adrenolytic action of pertussis toxin in rats; a prostaglandin-mediated phenomenon.
Infection of newborn piglets with Bordetella pertussis: a new model for pertussis.
Inhibition of lymphocyte circulation in mice by pertussis toxin.
Marked increase in L-selectin-negative T cells in neonatal pertussis. The lymphocytosis explained?
Molecular mechanisms of lymphocyte extravasation. III. The loss of lymphocyte extravasation potential induced by pertussis toxin is not mediated via the activation of protein kinase C.
Pertussis toxin induces lymphocytosis in rhesus macaques.
Pertussis toxin treatment in vivo reduces surface expression of the adhesion integrin leukocyte function antigen-1 (LFA-1).
Reovirus transport--studies using lymphocytosis promoting factor.
Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying.
Studies on the lymphocytosis induced by pertussis toxin.
The lymphocytosis promoting action of pertussis toxin can be mimicked in vitro. Holotoxin but not the B subunit inhibits invasion of human T lymphoma cells through fibroblast monolayers.
The lymphocytosis-promoting agent pertussis toxin affects virus burden and lymphocyte distribution in the SIV-infected rhesus macaque.
The prevention of severe pertussis and pertussis deaths in young infants.
Lymphoma
3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.
A multi-centre phase I trial of the PARP inhibitor olaparib in patients with relapsed chronic lymphocytic leukaemia, T-prolymphocytic leukaemia or mantle cell lymphoma.
A polysaccharide from the fruiting bodies of Agaricus blazei Murill induces caspase-dependent apoptosis in human leukemia HL-60 cells.
A role of intracellular mono-ADP-ribosylation in cancer biology.
Amplification of cyclic AMP generation reveals agonistic effects of certain beta-adrenergic antagonists.
An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity.
Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells.
Antrodia salmonea-induced oxidative stress abrogates HER-2 signaling cascade and enhanced apoptosis in ovarian carcinoma cells.
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase.
Apoptosis in the absence of cytochrome c accumulation in the cytosol.
Assessment of diarrhea as side effect of oral targeted antineoplastic agents in clinical practice.
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity.
Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different flip isoforms.
Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition.
Chlorophyllin e6?mediated photodynamic therapy inhibits proliferation and induces apoptosis in human bladder cancer cells.
Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells.
Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice.
Correlation of poly(ADP-ribose)polymerase and p53 expression levels in high-grade lymphomas.
Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination.
Cytotoxicity of Gymnopilus purpureosquamulosus extracts on hematologic malignant cells through activation of the SAPK/JNK signaling pathway.
Dimethyl sulfoxide activates tumor necrosis factor?-p53 mediated apoptosis and down regulates d-fructose-6-phosphate-2-kinase and lactate dehydrogenase-5 in Dalton's lymphoma in vivo.
Dual effects of pertussis toxin on in vitro invasive behavior of metastatic lymphoma variants.
Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells.
Effect of Shuangdan Mingmu capsule, a Chinese herbal formula, on oxidative stress-induced apoptosis of pericytes through PARP/GAPDH pathway.
Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53.
FADD expression and caspase activation in B-cell lymphomas resistant to Fas-mediated apoptosis.
Gi and Gq/11 proteins are involved in dissemination of myeloid leukemia cells to the liver and spleen, whereas bone marrow colonization involves Gq/11 but not Gi.
Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family.
Granzyme B leakage-induced apoptosis is a crucial mechanism of cell death in nasal-type NK/T-cell lymphoma.
HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway.
Immunohistochemical detection of poly(ADP-ribose) polymerase inhibition by ABT-888 in patients with refractory solid tumors and lymphomas.
Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells.
Inhibition of lymphoma invasion and liver metastasis formation by pertussis toxin.
Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching.
Interactions between a lymphoma membrane-associated guanosine 5'-triphosphate-binding protein and the cytoskeleton during receptor patching and capping.
Leukemic non-nodal mantle cell lymphomas have a distinct phenotype and are associated with deletion of PARP1 and 13q14.
Ligation of CD40 potentiates Fas-mediated activation of the cysteine protease CPP32, cleavage of its death substrate PARP, and apoptosis in Ramos-Burkitt lymphoma B cells.
Ligation of CD40 rescues Ramos-Burkitt lymphoma B cells from calcium ionophore- and antigen receptor-triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP.
Linarin sensitizes tumor necrosis factor-related apoptosis (TRAIL)-induced ligand-triggered apoptosis in human glioma cells and in xenograft nude mice.
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.
Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory site.
Modulation of prolactin-stimulated Nb2 lymphoma cell mitogenesis by cholera toxin and pertussis toxin.
Modulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells.
Modulation of the antiproliferative activity of anticancer drugs in hematopoietic tumor cell lines by the poly(ADP-ribose) polymerase inhibitor 6(5H)-phenanthridinone.
Motexafin gadolinium induces mitochondrially-mediated caspase-dependent apoptosis.
Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.
Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.
PARP activation promotes nuclear AID accumulation in lymphoma cells.
PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.
PARP1 expression in mantle cell lymphoma: the utility of PARP1 immunohistochemistry and its relationship with markers of DNA damage.
PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage.
PARP9 is overexpressed in human breast cancer and promotes cancer cell migration.
Pertussis toxin B-subunit-induced Ca2(+)-fluxes in Jurkat human lymphoma cells: the action of long-term pre-treatment with cholera and pertussis holotoxins.
Pertussis toxin catalyzes the ADP-ribosylation of two distinct peptides, 40 and 41 kDa, in rat fat cell membranes.
Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide.
Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas.
Poly(ADP-ribose) polymerase inhibitors combined with external beam and radioimmunotherapy to treat aggressive lymphoma.
Quercetin-3-O-(2?-galloyl)-?-L-rhamnopyranoside attenuates cholesterol oxidation product-induced apoptosis by suppressing NF-?B-mediated cell death process in differentiated PC12 cells.
Rationale for PARP inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.
Resveratrol inhibits proliferation and migration through SIRT1 mediated post?translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells.
Robust immunoglobulin class switch recombination and end joining in Parp9-deficient mice.
Role of nicotinamide adenine dinucleotide and adenosine triphosphate in glucocorticoid-induced cytotoxicity in susceptible lymphoid cells.
Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma.
The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases.
The Effects of 5,6,7,8,3',4'-Hexamethoxyflavone on Apoptosis of Cultured Human Choriocarcinoma Trophoblast Cells.
The effects of benzamide ADP-ribosyl transferase inhibitors on cell survival and DNA strand-break repair in irradiated mammalian cells.
The In Vitro and In Vivo Anticancer Properties of Chalcone Flavokawain B through Induction of ROS-Mediated Apoptotic and Autophagic Cell Death in Human Melanoma Cells.
The lymphocytosis promoting action of pertussis toxin can be mimicked in vitro. Holotoxin but not the B subunit inhibits invasion of human T lymphoma cells through fibroblast monolayers.
The PARP inhibitor olaparib enhances the cytotoxicity of combined gemcitabine, busulfan and melphalan in lymphoma cells.
Triptonide acts as a novel potent anti-lymphoma agent with low toxicity mainly through inhibition of proto-oncogene Lyn transcription and suppression of Lyn signal pathway.
Lymphoma, B-Cell
3,5-Diethoxy-3'-Hydroxyresveratrol (DEHR) Ameliorates Liver Fibrosis via Caveolin-1 Activation in Hepatic Stellate Cells and in a Mouse Model of Bile Duct Ligation Injury.
A diphenyl diselenide-supplemented diet and swimming exercise promote neuroprotection, reduced cell apoptosis and glial cell activation in the hypothalamus of old rats.
Analysis and Identification of Active Compounds from Gami-Soyosan Toxic to MCF-7 Human Breast Adenocarcinoma Cells.
Anti-cancer effects of 2-oxoquinoline derivatives on the HCT116 and LoVo human colon cancer cell lines.
Anti-Cancer Properties of Theaflavins.
Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line.
Anticancer effects of eleven triterpenoids derived from Antrodia camphorata.
Anticancer effects of oleanolic acid on human melanoma cells.
Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NF?B signaling in HER2-overexpressing breast cancer cells.
Apoptosis in B-cell lymphomas and reactive lymphoid tissues always involves activation of caspase 3 as determined by a new in situ detection method.
Apoptosis in human compressive myelopathy due to metastatic neoplasia.
Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA-MB231 breast cancer cells.
BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death.
Cadmium Activates Reactive Oxygen Species-dependent AKT/mTOR and Mitochondrial Apoptotic Pathways in Neuronal Cells.
Cadmium-induced apoptosis in neuronal cells is mediated by Fas/FasL-mediated mitochondrial apoptotic signaling pathway.
CCT020312 Inhibits Triple-Negative Breast Cancer Through PERK Pathway-Mediated G1 Phase Cell Cycle Arrest and Apoptosis.
Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9.
Characterization and anti-tumor activity of saponin-rich fractions of South Korean sea cucumbers (Apostichopus japonicus).
Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines.
Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk.
Clinical case report of patients with osteosarcoma and anticancer benefit of calycosin against human osteosarcoma cells.
Coix lacryma-jobi var. ma-yuen Stapf sprout extract induces cell cycle arrest and apoptosis in human cervical carcinoma cells.
Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/?-Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis.
Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice.
Down-expression of poly(ADP-ribose) polymerase in p53-regulated pancreatic cancer cells.
Effect of Shuangdan Mingmu capsule, a Chinese herbal formula, on oxidative stress-induced apoptosis of pericytes through PARP/GAPDH pathway.
Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78.
Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis.
EX527, a Sirt-1 inhibitor, induces apoptosis in glioma via activating the p53 signaling pathway.
Flavonoids isolated from Citrus platymamma induced G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells.
Galbanic acid potentiates TRAIL induced apoptosis in resistant non-small cell lung cancer cells via inhibition of MDR1 and activation of caspases and DR5.
Inhibition of Proliferation in U937 Cells Treated by Blue Light Irradiation and Combined Blue Light Irradiation/Drug.
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching.
Inhibitory effects of nodakenin on inflammation and cell death in lipopolysaccharide-induced liver injury mice.
Inulin Induces Dendritic Cells Apoptosis through the Caspase-Dependent Pathway and Mitochondrial Dysfunction.
Knockdown of stromal interaction molecule 1 inhibits proliferation of colorectal cancer cells by inducing apoptosis.
Korean Red Ginseng Extract Enhances the Anticancer Effects of Sorafenib through Abrogation of CREB and c-Jun Activation in Renal Cell Carcinoma.
Miltirone-induced apoptosis in cisplatin-resistant lung cancer cells through upregulation of p53 signaling pathways.
miR-30d inhibits cell biological progression of Ewing's sarcoma by suppressing the MEK/ERK and PI3K/Akt pathways
Naphthazarin suppresses cell proliferation and induces apoptosis in human colorectal cancer cells via the B-cell lymphoma 2/B-cell associated X protein signaling pathway.
Neuroprotective and antioxidant activities of bamboo salt soy sauce against H2O2-induced oxidative stress in rat cortical neurons.
Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway.
Novel proapoptotic agent SM-1 enhances the inhibitory effect of 5-fluorouracil on colorectal cancer cells in vitro and in vivo.
Palmitic Acid-Induced Podocyte Apoptosis via the Reactive Oxygen Species-Dependent Mitochondrial Pathway.
Pipoxolan Exhibits Antitumor Activity Toward Oral Squamous Cell Carcinoma Through Reactive Oxygen Species-mediated Apoptosis.
Polychlorinated biphenyl quinone induces mitochondrial-mediated and caspase-dependent apoptosis in HepG2 cells.
Protective effect of hypoxylonol C and 4,5,4',5'-tetrahydroxy-1,1'-binaphthyl isolated from Annulohypoxylon annulatum against streptozotocin-induced damage in INS-1 cells.
Quercetin-3-O-(2?-galloyl)-?-L-rhamnopyranoside attenuates cholesterol oxidation product-induced apoptosis by suppressing NF-?B-mediated cell death process in differentiated PC12 cells.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Research Progress on PARP14 as a Drug Target.
Role of Exogenous Hsp72 on Liver Dysfunction during Sepsis.
Serum-free corneal organ culture medium (SFM) but not conventional minimal essential organ culture medium (MEM) protects human corneal endothelial cells from apoptotic and necrotic cell death.
Silencing LDHA inhibits proliferation, induces apoptosis and increases chemosensitivity to temozolomide in glioma cells.
Target prioritization of novel substituted 5-aryl-2-oxo-/thioxo-2,3-dihydro-1H-benzo[6,7]chromeno[2,3-d]pyrimidine-4,6,11(5H)-triones as anticancer agents using in-silico approach.
The Effects of 5,6,7,8,3',4'-Hexamethoxyflavone on Apoptosis of Cultured Human Choriocarcinoma Trophoblast Cells.
The PARP inhibitor veliparib can be safely added to bendamustine and rituximab and has preliminary evidence of activity in B-cell lymphoma.
The role of mitogen-activated protein kinase in cadmium-induced primary rat cerebral cortical neurons apoptosis via a mitochondrial apoptotic pathway.
Toona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma.
Transferrin-conjugated liposomes loaded with carnosic acid inhibit liver cancer growth by inducing mitochondria-mediated apoptosis.
Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors.
Lymphoma, Large B-Cell, Diffuse
BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death.
Lysosomotropic cationic drugs induce cytostatic and cytotoxic effects: Role of liposolubility and autophagic flux and antagonism by cholesterol ablation.
Mechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells.
Research Progress on PARP14 as a Drug Target.
Lymphoma, Mantle-Cell
A multi-centre phase I trial of the PARP inhibitor olaparib in patients with relapsed chronic lymphocytic leukaemia, T-prolymphocytic leukaemia or mantle cell lymphoma.
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53.
Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.
Linarin sensitizes tumor necrosis factor-related apoptosis (TRAIL)-induced ligand-triggered apoptosis in human glioma cells and in xenograft nude mice.
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.
PARP1 expression in mantle cell lymphoma: the utility of PARP1 immunohistochemistry and its relationship with markers of DNA damage.
Lymphoma, Non-Hodgkin
Correlation of poly(ADP-ribose)polymerase and p53 expression levels in high-grade lymphomas.
PARP-1 protein expression in glioblastoma multiforme.
PARP-1 Val762Ala polymorphism is associated with reduced risk of non-Hodgkin lymphoma in Korean males.
Poly(ADP-ribose) polymerase inhibitors combined with external beam and radioimmunotherapy to treat aggressive lymphoma.
Response of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation.
Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types.
Lymphoma, T-Cell
Molecular cloning of a functional murine arginine-specific mono-ADP-ribosyltransferase and its expression in lymphoid cells.
Lymphoma, T-Cell, Cutaneous
The synergistic proapoptotic effect of PARP-1 and HDAC inhibition in cutaneous T-cell lymphoma is mediated via Blimp-1.
Lymphopenia
Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function.
Macular Degeneration
Protective effects of PARP1-inhibitory compound in dry age-related macular degeneration.
Malaria
The pathophysiology of falciparum malaria.
Mastitis
Assessment of Poly(ADP-ribose) Polymerase1 (PARP1) expression and activity in cells purified from blood and milk of dairy cattle.
New Insights into the Significance of PARP-1 Activation: Flow Cytometric Detection of Poly(ADP-Ribose) as a Marker of Bovine Intramammary Infection.
Mastocytoma
Characterization of cytosolic pertussis toxin-sensitive GTP-binding protein in mastocytoma P-815 cells.
Trichostatin A induces apoptosis of p815 mastocytoma cells in histone acetylation- and mitochondria-dependent fashion.
Mastocytosis
Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells.
Measles
Antibody responses of healthy infants to concurrent administration of a bivalent haemophilus influenzae type b-hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines.
Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019.
Medulloblastoma
A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors.
Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model.
Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.
Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas.
Expression of Gli1 and PARP1 in medulloblastoma: an immunohistochemical study of 65 cases.
Medulloblastoma in mice lacking p53 and PARP: all roads lead to Gli.
Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice.
PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.
PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma.
PARP1 expression in pediatric central nervous system tumors.
Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis.
Veliparib Is an Effective Radiosensitizing Agent in a Preclinical Model of Medulloblastoma.
Melanoma
17-Aminogeldanamycin selectively diminishes IRE1?-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAFV600E inhibitors in melanoma cells of different genetic subtypes.
4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.
4-Thiazolidinone derivative Les-3833 effectively inhibits viability of human melanoma cells through activating apoptotic mechanisms.
A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF.
A dermatan sulfate-functionalized biomimetic nanocarrier for melanoma targeted chemotherapy.
A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation.
A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression.
A375 melanoma cells are sensitized to cisplatin-induced toxicity by a synthetic nitro-flavone derivative 2-(4-Nitrophenyl)-4H-chromen-4-one through inhibition of PARP1.
Activating the Wnt/?-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3.
Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells.
Altered Expression of the Poly(ADP-Ribosyl)ation Enzymes in Uveal Melanoma and Regulation of PARG Gene Expression by the Transcription Factor ERM.
An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs.
Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma.
Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition.
Apoptotic Effect of Astragalin in Melanoma Skin Cancers via Activation of Caspases and Inhibition of Sry-related HMg-Box Gene 10.
Approach to the Triple Negative Breast Cancer in New Drugs Area.
Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27.
Attenuation of genotoxicity under adhesion-restrictive conditions through modulation of p53, gamma H2AX and nuclear DNA organization.
Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity.
Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors.
BRIT-1 expression and its relationship with PARP-1 and CAF-1/p60 in cutaneous melanoma.
c-Myc is able to sensitize human melanoma cells to diverse apoptotic triggers.
Cepharanthine exerts antitumor activity on choroidal melanoma by reactive oxygen species production and c-Jun N-terminal kinase activation.
Characterization of human melanoma cell lines according to their migratory properties in vitro.
Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma.
Combination of PDT and inhibitor treatment affects melanoma cells and spares keratinocytes.
Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma.
Cyclosporine A and its non-immunosuppressive derivative NIM811 induce apoptosis of malignant melanoma cells in in vitro and in vivo studies.
Deficiency of C-C chemokine receptor 5 suppresses tumor development via inactivation of NF-?B and upregulation of IL-1Ra in melanoma model.
Dibutyltin(IV) and Tributyltin(IV) Derivatives of meso-Tetra(4-sulfonatophenyl)porphine Inhibit the Growth and the Migration of Human Melanoma Cells.
Differential regulation of CXC ligand 1 transcription in melanoma cell lines by poly(ADP-ribose) polymerase-1.
Dimethylfumarate inhibits melanoma cell proliferation via p21 and p53 induction and bcl-2 and cyclin B1 downregulation.
Effect of ABT-888 on the apoptosis, motility and invasiveness of BRAFi-resistant melanoma cells.
eIF4E Is an Adverse Prognostic Marker of Melanoma Patient Survival by Increasing Melanoma Cell Invasion.
Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells.
Endothelin receptor B inhibition triggers apoptosis and enhances angiogenesis in melanomas.
Enhanced anti-melanoma efficacy of interferon ?-2b via overexpression of ING4 by enhanced Fas/FasL-mediated apoptosis.
Evaluation of anti-melanoma activities of (1S,2E,4R,6E,8R,11S,12R)-8,12-epoxy-2,6-cembradiene-4,11-diol, (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol from the Red Sea soft coral Sarcophyton glaucum.
Evaluation of the anti-melanoma activities of sarcophine, (+)-7alpha,8beta-dihydroxydeepoxysarcophine and sarcophytolide from the Red Sea soft coral Sarcophyton glaucum.
Exoenzyme C3 transferase lowers actin cytoskeleton dynamics, genomic stability and survival of malignant melanoma cells under UV-light stress.
Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells.
G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones.
Genetic variants in PARP1 (rs3219090) and IRF4 (rs12203592) genes associated with melanoma susceptibility in a Spanish population.
Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma.
Genetic variation in DNA repair pathway genes and melanoma risk.
Hazelnut (Corylus avellana L.) Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines.
HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis.
Human melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by Cisplatin.
Iciartin, a novel FASN inhibitor, exerts anti-melanoma activities through IGF-1R/STAT3 signaling.
Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.
Identifying new piperazine-based PARP1 inhibitors using text mining and integrated molecular modeling approaches.
Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells.
Inherited genetic variants associated with occurrence of multiple primary melanoma.
Inherited variation in the PARP1 gene and survival from melanoma.
Inhibition of AURKB, regulated by pseudogene MTND4P12, confers synthetic lethality to PARP inhibition in skin cutaneous melanoma.
Inhibition of melanoma growth and metastasis by ATF2-derived peptides.
Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line.
Inhibition of Poly(ADP-Ribose) Polymerase Enhances the Effect of Chemotherapy in an Animal Model of Regional Therapy for the Treatment of Advanced Extremity Malignant Melanoma.
Inhibition of SOX4 induces melanoma cell apoptosis via downregulation of NF-?B p65 signaling.
Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.
Isolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells.
Lauroside B, a megastigmane glycoside from Laurus nobilis (bay laurel) leaves, induces apoptosis in human melanoma cell lines by inhibiting NF-?B activation.
Loss of function of vascular smooth muscle cells by nitric oxide-dependent and -independent interactions with tumorigenic cells.
Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ?.
Metabolic utilization of exogenous pyruvate by mutant p53(R175H) human melanoma cells promotes survival under glucose depletion.
Methoxyphenylcipro induces antitumor activity in human cancer cells.
MITF suppression improves the sensitivity of melanoma cells to a BRAF inhibitor.
Mitochondrial transmembrane potential in spontaneous and camptothecin-induced apoptosis of melanotic and amelanotic melanoma cells.
MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells.
Molecular, Biological and Structural Features of VL CDR-1 Rb44 Peptide, Which Targets the Microtubule Network in Melanoma Cells.
Murine melanoma cell differentiation and melanogenesis induced by poly(ADP-ribose) polymerase inhibitors.
Mutation clearance and complete radiologic resolution of immunotherapy relapsed metastatic melanoma after treatment with nivolumab and olaparib in a patient with homologous recombinant deficiency: any role for PARP inhibitors and checkpoint blockade?
Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia.
Onconase Restores Cytotoxicity in Dabrafenib-Resistant A375 Human Melanoma Cells and Affects Cell Migration, Invasion and Colony Formation Capability.
Overexpression of HSP70 prevents ultraviolet B-induced apoptosis of a human melanoma cell line.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues - A population pharmacokinetic/pharmacodynamic analysis of rucaparib.
PARP Inhibition Increases the Response to Chemotherapy in Uveal Melanoma.
PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells.
PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts.
PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation.
PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation.
PARP1 as a Marker of an Aggressive Clinical Phenotype in Cutaneous Melanoma-A Clinical and an In Vitro Study.
PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas.
PARP1 Inhibitors: antitumor drug design.
PARP1 polymorphisms play opposing roles in melanoma occurrence and survival.
Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells.
Pharmacological Inhibition of Poly(ADP-ribose) Polymerase (PARP) Activity in PARP-1 Silenced Tumour Cells Increases Chemosensitivity to Temozolomide and to a N3-Adenine Selective Methylating Agent.
Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent.
Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region.
Poly(Adenosine Diphosphate-Ribose) Polymerase-1 Expression in Cutaneous Malignant Melanomas as a New Molecular Marker of Aggressive Tumor.
Poly(ADP-ribose) in the skin and in melanomas.
Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population.
Prenylation Inhibition-Induced Cell Death in Melanoma: Reduced Sensitivity in BRAF Mutant/PTEN Wild-Type Melanoma Cells.
Prevalence of Homologous Recombination Pathway Gene Mutations in Melanoma: Rationale for a New Targeted Therapeutic Approach.
Radiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer Vaccine.
Radiosynthesis of 3 H- and 14 C-labeled Veliparib.
Rare germline copy number variations and disease susceptibility in familial melanoma.
RIN1 exhibits oncogenic property to suppress apoptosis and its aberrant accumulation associates with poor prognosis in melanoma.
Sasanquasaponin ??? from Schima crenata Korth induces autophagy through Akt/mTOR/p70S6K pathway and promotes apoptosis in human melanoma A375 cells.
Selective modulation by PARP-1 of HIF-1?-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions.
Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity.
Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response.
Synergistic apoptosis-inducing effects on A375 human melanoma cells of natural borneol and curcumin.
Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma.
Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression.
Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells.
Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.
Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53.
The 1q42.1 Risk Allele Promotes Melanoma via PARP1 Upregulation.
The activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell.
The Antitumor Activity of Antrodia camphorata in Melanoma Cells: Modulation of Wnt/?-Catenin Signaling Pathways.
The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines.
The melanoma specific 9.2.27PE immunotoxin efficiently kills melanoma cells in vitro.
The Prognostic Values of PARP-1 Expression in Uveal Melanoma.
The role of G-protein in matrix-mediated motility of highly and poorly invasive melanoma cells.
The toxicity of nitrofuran compounds on melanoma and neuroblastoma cells is enhanced by Olaparib and ameliorated by melanin pigment.
Topical 2'-Hydroxyflavanone for Cutaneous Melanoma.
Tumor apoptosis induced by ruthenium(II)-ketoconazole is enhanced in nonsusceptible carcinoma by monoclonal antibody to EGF receptor.
Type IV collagen stimulates an increase in intracellular calcium. Potential role in tumor cell motility.
Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas.
Xeroderma Pigmentosum Group A Promotes Autophagy to Facilitate Cisplatin Resistance in Melanoma Cells through the Activation of PARP1.
Melanoma, Experimental
Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation.
Memory Disorders
Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1.
TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice.
Meniere Disease
Poly(ADP-ribose) polymerase-1 (PARP-1) longer alleles spanning the promoter region may confer protection to bilateral Meniere's disease.
Meningioma
Expression of a functional endothelin (ETA) receptor in human meningiomas.
Poly(ADP-ribose) polymerase-1 (PARP1) and p53 labelling index correlates with tumour grade in meningiomas.
Meningitis
SNPs in DNA repair genes associated to meningitis and host immune response.
Meningitis, Bacterial
A putative role for homocysteine in the pathophysiology of acute bacterial meningitis in children.
Advances in adjuvant therapy against acute bacterial meningitis.
Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase.
Meningitis, Pneumococcal
Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase.
Meningococcal Infections
Polymorphisms in PARP, IL1B, IL4, IL10, C1INH, DEFB1 and DEFA4 in meningococcal disease in three populations.
Mesothelioma
Analysis of CCDC6 as a novel biomarker for the clinical use of PARP1 inhibitors in malignant pleural mesothelioma.
BAP1-Altered Malignant Pleural Mesothelioma: Outcomes With Chemotherapy, Immune Check-Point Inhibitors and Poly(ADP-Ribose) Polymerase Inhibitors.
Blockage of epithelial to mesenchymal transition and upregulation of let 7b are critically involved in ursolic acid induced apoptosis in malignant mesothelioma cell.
Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells.
Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma.
Hesperidin Induces Apoptosis by Inhibiting Sp1 and Its Regulatory Protein in MSTO-211H Cells.
Initial evaluation of Cu-64 labeled PARPi-DOTA PET imaging in mice with mesothelioma.
PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1.
Reduced cell viability and apoptosis induction in human thyroid carcinoma and mesothelioma cells exposed to cidofovir.
Rucaparib in patients with BAP1-deficient or BRCA1-deficient mesothelioma (MiST1): an open-label, single-arm, phase 2a clinical trial.
Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression.
Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition.
Taurolidine and oxidative stress: a rationale for local treatment of mesothelioma.
Unsymmetric Cisplatin-Based Pt(IV) Conjugates Containing a PARP-1 Inhibitor Pharmacophore Tested on Malignant Pleural Mesothelioma Cell Lines.
Mesothelioma, Malignant
Analysis of CCDC6 as a novel biomarker for the clinical use of PARP1 inhibitors in malignant pleural mesothelioma.
Analysis of mutations of PARP1, RNF213, PAX8, KMT2C, MTRR in malignant mesothelioma of testicular tunica vaginalis testis.
Anticarcinogenic effects of halofuginone on lung-derived cancer cells.
BAP1-Altered Malignant Pleural Mesothelioma: Outcomes With Chemotherapy, Immune Check-Point Inhibitors and Poly(ADP-Ribose) Polymerase Inhibitors.
Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma.
Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition.
Unsymmetric Cisplatin-Based Pt(IV) Conjugates Containing a PARP-1 Inhibitor Pharmacophore Tested on Malignant Pleural Mesothelioma Cell Lines.
Metabolic Diseases
Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases.
Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance.
Inhibition of Poly(ADP-Ribose) Polymerase Increased Lipid Accumulation Through SREBP1 Modulation.
Metabolic roles of poly(ADP-ribose) polymerases.
Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy.
PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation.
Poly(ADP-ribose) polymerases in aging - friend or foe?
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Metabolic Syndrome
Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch.
Microcephaly
Genotype-phenotype relationship in a child with 2.3 Mb de novo interstitial 12p13.33-p13.32 deletion.
Mitochondrial Diseases
Insights into the functional aspects of poly(ADP-ribose) polymerase-1 (PARP-1) in mitochondrial homeostasis in Dictyostelium discoideum.
Pharmacological NAD-Boosting Strategies Improve Mitochondrial Homeostasis in Human Complex I-Mutant Fibroblasts.
Monoclonal Gammopathy of Undetermined Significance
Altered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma.
Targeting the MALAT1/PARP1/LIG3 complex induces DNA damage and apoptosis in multiple myeloma.
Mouth Neoplasms
Anticancer effects of eleven triterpenoids derived from Antrodia camphorata.
Apoptosis induced by caffeic acid phenethyl ester in human oral cancer cell lines: Involvement of Puma and Bax activation.
Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent.
Fluorescence-guided resection of tumors in mouse models of oral cancer.
In Vitro Assessment of the Anticancer Potential of Evodiamine in Human Oral Cancer Cell Lines.
Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells.
Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway.
Mechanism of sappanchalcone-induced growth inhibition and apoptosis in human oral cancer cells.
Methanol Extract of Usnea barbata Induces Cell Killing, Apoptosis, and DNA Damage against Oral Cancer Cells through Oxidative Stress.
MicroRNA-205 suppresses the oral carcinoma oncogenic activity via down-regulation of Axin-2 in KB human oral cancer cell.
Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio.
Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly.
Optical Imaging of PARP1 in Response to Radiation in Oral Squamous Cell Carcinoma.
Oridonin induces apoptosis in oral squamous cell carcinoma probably through the generation of reactive oxygen species and the p38/JNK MAPK pathway.
Overexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer.
PARP inhibitor Olaparib Enhances the Apoptotic Potentiality of Curcumin by Increasing the DNA Damage in Oral Cancer Cells through Inhibition of BER Cascade.
PARP inhibitor Veliparib (ABT-888) enhances the anti-angiogenic potentiality of Curcumin through deregulation of NECTIN-4 in oral cancer: Role of nitric oxide (NO).
Poly (ADP-Ribose) Polymerase Inhibitor, ABT888, Improved Cisplatin Effect in Human Oral Cell Carcinoma.
Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cells.
Preventive measures in oral cancer: An overview.
Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo.
Tetrandrine induces apoptosis Via caspase-8, -9, and -3 and poly (ADP ribose) polymerase dependent pathways and autophagy through beclin-1/ LC3-I, II signaling pathways in human oral cancer HSC-3 cells.
The Apoptotic Effect of the Hexane Extract of Rheum undulatum L. in Oral Cancer Cells through the Down-regulation of Specificity Protein 1 and Survivin.
MPTP Poisoning
A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism.
Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism.
SPATIAL AND FUNCTIONAL RELATIONSHIP BETWEEN POLY(ADP-RIBOSE) POLYMERASE-1 AND POLY(ADP-RIBOSE) GLYCOHYDROLASE IN THE BRAIN.
Mucositis
Efficacy of professionally-administered plaque removal with or without adjunctive measures for the treatment of peri-implant mucositis. A systematic review and meta-analysis.
Multiple Endocrine Neoplasia
[Molecular Targeted Therapies for Hereditary Cancer Syndrome].
Multiple Endocrine Neoplasia Type 2a
[Molecular Targeted Therapies for Hereditary Cancer Syndrome].
Multiple Myeloma
A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition.
A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.
Altered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma.
Bortezomib-induced "BRCAness" sensitizes multiple myeloma cells to PARP inhibitors.
Cladribine in combination with entinostat synergistically elicits anti-proliferative/anti-survival effects on multiple myeloma cells.
Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14).
Cytotoxicity of Gymnopilus purpureosquamulosus extracts on hematologic malignant cells through activation of the SAPK/JNK signaling pathway.
Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells.
Inhibition of Pim-2 kinase by LT-171-861 promotes DNA damage and exhibits enhanced lethal effects with PARP inhibitor in multiple myeloma.
Loss of heterozygosity as a marker of homologous repair deficiency in multiple myeloma: a role for PARP inhibition?
PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R.
Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma.
Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.
Research Progress on PARP14 as a Drug Target.
Targeting poly (ADP-ribose) polymerase partially contributes to bufalin-induced cell death in multiple myeloma cells.
TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins.
[Effect of PARP1 inhibitor PJ34 on multi-drug resistance in human multiple myeloma cell line and its relationship with FA/BRCA pathway].
Multiple Sclerosis
Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model.
Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death.
Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin.
PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis.
PARP-1 deregulation in multiple sclerosis.
Pertussis toxin attenuates experimental autoimmune encephalomyelitis by upregulating neuronal vascular endothelial growth factor.
Pertussis toxin induces angiogenesis in brain microvascular endothelial cells.
Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis.
Poly(ADP-ribose) polymerase-1 activation in a primate model of multiple sclerosis.
The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis.
The regulatory effect of liuwei dihuang pills on cytokines in mice with experimental autoimmune encephalomyelitis.
Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis.
Mumps
Antibody responses of healthy infants to concurrent administration of a bivalent haemophilus influenzae type b-hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines.
Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019.
Murine Acquired Immunodeficiency Syndrome
Parthanatos-associated proteins are stimulated intraocularly during development of experimental murine cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression.
Muscle Hypotonia
Genotype-phenotype relationship in a child with 2.3 Mb de novo interstitial 12p13.33-p13.32 deletion.
Muscular Atrophy
Absence of Caspase-3 Protects Against Denervation Induced Skeletal Muscle Atrophy.
Neer Award 2016: reduced muscle degeneration and decreased fatty infiltration after rotator cuff tear in a poly(ADP-ribose) polymerase 1 (PARP-1) knock-out mouse model.
Muscular Diseases
Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis.
Muscular Dystrophies
Telomere shortening is associated to TRF1 and PARP1 overexpression in Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Telomere shortening is associated to TRF1 and PARP1 overexpression in Duchenne muscular dystrophy.
Mycosis Fungoides
Therapeutic and prognostic significance of PARP-1 in advanced mycosis fungoides and Sezary syndrome.
Myelitis
Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury.
IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis.
Inhibition of tyrosine kinase-mediated cellular signalling by Tyrphostins AG126 and AG556 modulates secondary damage in experimental spinal cord trauma.
Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma.
Myelodysplastic Syndromes
Bone marrow PARP1 mRNA levels predict response to treatment with 5-azacytidine in patients with myelodysplastic syndrome.
Can synthetic lethality approach be used with DNA repair genes for primary and secondary MDS?
Cytotoxicity and Differentiating Effect of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib in Myelodysplastic Syndromes.
Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes.
Microsatellite instability induced mutations in DNA repair genes Ctip and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors in myeloidmalignancies.
Myelodysplastic syndrome and acute myeloid leukaemia in patients treated with PARP inhibitors: a safety meta-analysis of randomised controlled trials and a retrospective study of the WHO pharmacovigilance database.
PARP inhibitors-understanding the risk of myelodysplastic syndrome and acute myeloid leukaemia.
PARP1 V762A polymorphism affects the prognosis of myelodysplastic syndromes.
Poly (ADP-ribose) polymerase 1 mRNA levels strongly correlate with the prognosis of myelodysplastic syndromes.
Poly (ADP-ribose) polymerase-1 (PARP1) as a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.
The poly (ADP ribose) polymerase inhibitor niraparib: Management of toxicities.
Myocardial Infarction
A novel and orally active poly(ADP-ribose) polymerase inhibitor, KR-33889 [2-[methoxycarbonyl(4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic acid amide], attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia.
A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial.
Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes.
Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction.
Acute myocardial infarction induced increases in plasma tumor necrosis factor-alpha and interleukin-10 are associated with the activation of poly(ADP-ribose) polymerase of circulating mononuclear cell.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Effects of 3-aminobenzamide on expressions of poly (ADP ribose) polymerase and apoptosis inducing factor in cardiomyocytes of rats with acute myocardial infarction.
Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors.
Increased Poly (ADP-ribosyl)ation in Peripheral Leukocytes and the Reperfused Myocardium Tissue of Rats with Ischemia/Reperfusion Injury: Prevention by 3-Aminobenzamide Treatment.
Inhibition of the activity of poly (ADP-ribose) polymerase reduces heart ischaemia/reperfusion injury via suppressing JNK-mediated AIF translocation.
Inhibition of the activity of Poly(ADP-Ribose) Polymerase reduces heart ischemia/reperfusion injury via suppressing JNK mediated AIF translocation.
Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin.
Isoflurane preconditions myocardium against infarction via activation of inhibitory guanine nucleotide binding proteins.
Local Administration of the Poly ADP-Ribose Polymerase (PARP) Inhibitor, PJ34 During Hindlimb Ischemia Modulates Skeletal Muscle Reperfusion Injury.
MicroRNA-577 inhibits cardiomyocyte apoptosis induced by myocardial infarction via targeting PARP1.
MicroRNA-760-mediated low expression of DUSP1 impedes the protective effect of NaHS on myocardial ischemia-reperfusion injury.
Minocycline improves cardiac function after myocardial infarction in rats by inhibiting activation of PARP-1.
Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption.
Natural Inhibitors of Poly(ADP-ribose) Polymerase-1.
PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.
PARP-1 inhibition attenuates cardiac fibrosis induced by myocardial infarction through regulating autophagy.
Poly (ADP-ribose) polymerase, nitric oxide and cell death.
Poly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator.
Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.
Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update.
Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor.
Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications.
Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications.
Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors.
Pretreatment of therapeutic cells with poly(ADP-ribose) polymerase inhibitor enhances their efficacy in an in vitro model of cell-based therapy in myocardial infarct.
Protective effect of diethylcarbamazine inhibits NF-?B activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway.
Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, angiographically verified coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus.
Reversible induction of PARP1 degradation by p53-inducible cis-imidazoline compounds.
Rho-kinase signaling pathway promotes the expression of PARP to accelerate cardiomyocyte apoptosis in ischemia/reperfusion.
Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure.
Specific protein 1 inhibitor mithramycin A protects cardiomyocytes from myocardial infarction via interacting with PARP.
Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences.
The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders.
The role of Akt and mitogen-activated protein kinase systems in the protective effect of poly(ADP-ribose) polymerase inhibition in Langendorff perfused and in isoproterenol-damaged rat hearts.
[Poly(ADP-ribose) polymerases-1 inhibitor MRL-45696 alleviates DNA damage after myocardial ischemia-reperfusion in diabetic rats].
Myocardial Ischemia
A novel and orally active poly(ADP-ribose) polymerase inhibitor, KR-33889 [2-[methoxycarbonyl(4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic acid amide], attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia.
Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury.
Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes.
Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors.
Development of a miniaturized assay for the high-throughput screening program for poly(ADP-ribose) polymerase-1.
Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.
In vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters.
Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy.
Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration.
Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption.
PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription.
Poly(ADP-ribose) polymerase inhibitors.
Prevalent role of Akt and ERK activation in cardioprotective effect of Ca(2+) channel- and beta-adrenergic receptor blockers.
Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences.
Therapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size.
Vasodilator signals from the ischemic myocardium are transduced to the coronary vascular wall by pertussis toxin-sensitive G proteins: a new experimental method for the analysis of the interaction between the myocardium and coronary vessels.
Myocardial Reperfusion Injury
Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury.
Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction.
Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure.
Beneficial effects of poly (ADP-ribose) polymerase inhibition against the reperfusion injury in heart transplantation.
Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.
Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration.
Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure.
Role of nitrosative stress and poly(ADP-ribose) polymerase activation in myocardial reperfusion injury.
Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences.
Myositis
Interleukin-37 (IL-37) Suppresses Pertussis Toxin-Induced Inflammatory Myopathy in a Rat Model.
Myxoma
Poxvirus infection rapidly activates tyrosine kinase signal transduction.
nad+ adp-ribosyltransferase deficiency
A possible role for telomerase RNA and telomere length in global mitotic recombination.
Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients.
B Cell-Intrinsic and -Extrinsic Regulation of Antibody Responses by PARP14, an Intracellular (ADP-Ribosyl)Transferase.
Changes in poly(ADP-ribose) level modulate the kinetics of DNA strand break rejoining.
Chromosomal aberrations in PARP(-/-) mice: genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA.
CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in BRCA1-mutated breast cancer cells.
Cytokine-mediated ?-cell damage in PARP-1-deficient islets.
Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells.
Differential susceptibility of normal and PARP knock-out mouse fibroblasts to proteasome inhibitors.
DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.
Effect of PARP-1 deficiency on DNA damage and repair in human bronchial epithelial cells exposed to Benzo(a)pyrene.
Effects of PARP-1 Deficiency and Histamine H4 Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice.
Effects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy antigen receptor for chemokines.
Effects of PARP-1 deficiency on Th1 and Th2 cell differentiation.
Erratum to: PARP10 deficiency manifests by severe developmental delay and DNA repair defect.
Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors.
Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family.
Increased Foxp3+ regulatory T cells in poly(ADP-Ribose) polymerase-1 deficiency.
Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy.
Investigation of the relative biological effectiveness and uniform isobiological killing effects of irradiation with a clinical carbon SOBP beam on DNA repair deficient CHO cells.
Loss of PARP-1 attenuates diabetic arteriosclerotic calcification via Stat1/Runx2 axis.
Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction.
Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase.
Modulation of Poly(ADP-Ribose) Polymerase-1 (PARP-1)-Mediated Oxidative Cell Injury by Ring Finger Protein 146 (RNF146) in Cardiac Myocytes.
Mutagenic effects of poly (ADP-ribose) polymerase-1 deficiency in transgenic mice.
Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability.
Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy.
Parg deficiency confers radio-sensitization through enhanced cell death in mouse ES cells exposed to various forms of ionizing radiation.
PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model.
Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent.
Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice.
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts.
PARP-1 DEFICIENCY EXACERBATES DIET-INDUCED OBESITY IN MICE.
Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.
Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment.
PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis.
PARP-1 involves in UVB-induced inflammatory response in keratinocytes and skin injury via regulation of ROS-dependent EGFR transactivation and p38 signaling.
Parp1 deficiency confers defects in chromatin surveillance and remodeling during reprogramming by nuclear transfer.
PARP1 deficiency protects against hyperglycemia-induced neointimal hyperplasia by upregulating TFPI2 activity in diabetic mice.
PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer.
PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres.
PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation.
PARP10 deficiency manifests by severe developmental delay and DNA repair defect.
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice.
Poly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator.
Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy.
Poly (ADP-ribose) polymerase-1 deficiency does not affect ethylnitrosourea mutagenicity in liver and testis of lacZ transgenic mice.
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2.
Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity.
Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aortic atherogenesis through downregulation of arginase II.
Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery.
Poly(ADP-ribose) polymerase suppression protects rheumatoid synovial fibroblasts from Fas-induced apoptosis.
Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation.
Poly(ADP-ribose) polymerase-1 modulates interferon-gamma-inducible protein (IP)-10 expression in murine embryonic fibroblasts by stabilizing IP-10 mRNA.
Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice.
Poly(ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein.
Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure.
Reduced stability of regularly spliced but not alternatively spliced p53 protein in PARP-deficient mouse fibroblasts.
Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age.
Role of poly(ADP-ribosyl)ation in a 'two-hit' model of hypoxia and oxidative stress in human A549 epithelial cells in vitro.
Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis.
Spontaneous Development of Dental Dysplasia in Aged Parp-1 Knockout Mice.
Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells.
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.
The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.
Transcriptional regulation by poly(ADP-ribose) polymerase-1 during T cell activation.
Transcriptional reprogramming and resistance to colonic mucosal injury in Poly(ADP-ribose) polymerase 1 (PARP1)-deficient mice.
Nasal Polyps
Intralesional bleomycin A5 injection for the treatment of nasal polyps through inducing apoptosis.
Nasopharyngeal Carcinoma
CHM-1 Suppresses Formation of Cell Surface-associated GRP78-p85? Complexes, Inhibiting PI3K-AKT Signaling and Inducing Apoptosis of Human Nasopharyngeal Carcinoma Cells.
Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis.
Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors.
PARP-1 promotes autophagy via the AMPK/mTOR pathway in CNE-2 human nasopharyngeal carcinoma cells following ionizing radiation, while inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells.
Poly(ADP-ribose) polymerase 1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy.
Poly(ADP-ribose) polymerase-1 regulates the mechanism of irradiation-induced CNE-2 human nasopharyngeal carcinoma cell autophagy and inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells.
Protein expression and intracellular localization of prostate apoptosis response-4 (Par-4) are associated with apoptosis induction in nasopharyngeal carcinoma cell lines.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53-cyclin B1/CDC2.
[Expression and Implication of Base Excision Repair Genes in Human Nasopharyngeal Carcinoma and Non-tumor Nasopharyngeal Tissues.]
Neoplasm Metastasis
5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients.
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage.
Advancements in PARP1 Targeted Nuclear Imaging and Theranostic Probes.
An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer.
Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma.
Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition.
ATMIN Suppresses Metastasis by Altering the WNT-Signaling Pathway via PARP1 in MSI-High Colorectal Cancer.
Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients.
Combination therapy with dacarbazine and statins improved the survival rate in mice with metastatic melanoma.
Deciphering the Insights of Poly(ADP-Ribosylation) in Tumor Progression.
Differential regulation of breast cancer bone metastasis by PARP1 and PARP2.
DNA damage response genes and the development of cancer metastasis.
Down-regulation of Notch receptor signaling pathway induces caspase-dependent and caspase-independent apoptosis in lung squamous cell carcinoma cells.
ERCC1, PARP-1, and AQP1 as predictive biomarkers in colon cancer patients receiving adjuvant chemotherapy.
Expression of PARP-1 and its active polymer PAR in prostate cancer and benign prostatic hyperplasia in Chinese patients.
Garcinol Inhibits Cell Proliferation and Promotes Apoptosis in Pancreatic Adenocarcinoma Cells.
Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.
High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer.
Identification of PARP-1 in cancer stem cells of gastrointestinal cancers: A preliminary study.
Individual and Combined Expression of DNA Damage Response Molecules PARP1, ?H2AX, BRCA1, and BRCA2 Predict Shorter Survival of Soft Tissue Sarcoma Patients.
Inhibition of lymphoma invasion and liver metastasis formation by pertussis toxin.
Integration of Comprehensive Genomic Analysis and Functional Screening of Affected Molecular Pathways to Inform Cancer Therapy.
Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2.
Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers.
PARG regulates the proliferation and differentiation of DCs and T cells via PARP/NF??B in tumour metastases of colon carcinoma.
PARP Inhibitor Olaparib Use in a BRCA1-Positive Patient With Metastatic Triple-Negative Breast Cancer, Without the Initial Use of Platinum-Based Chemotherapy, Showing Significant Rapid Near Resolution of Large Liver Metastasis While Patient Experienced Gout-Like Symptoms.
PARP-1 induces EMT in non-small cell lung carcinoma cells via modulating the transcription factors Smad4, p65 and ZEB1.
PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma.
PARP-1 inhibitor modulate ?-catenin signaling to enhance cisplatin sensitivity in cancer cervix.
PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population.
PARP1 as a Marker of an Aggressive Clinical Phenotype in Cutaneous Melanoma-A Clinical and an In Vitro Study.
PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair.
PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs.
PARP10 suppresses tumor metastasis through regulation of Aurora A activity.
PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines.
Pertussis toxin inhibition of T-cell hybridoma invasion is reversed by manganese-induced activation of LFA-1.
Poly(ADP-Ribose) Polymerase Inhibition Sensitizes Colorectal Cancer-Initiating Cells to Chemotherapy.
Poly(ADP-ribose)polymerase inhibition decreases angiogenesis.
Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer.
Response to Olaparib in a Patient with Germline BRCA2 Mutation and Breast Cancer Leptomeningeal Carcinomatosis.
RNF114 suppresses metastasis through regulation of PARP10 in cervical cancer cells.
Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.
SOX2 inhibits cell proliferation and metastasis, promotes apoptotic by downregulating CCND1 and PARP in gastric cancer.
Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy.
The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases.
The diagnostic value of DNA repair gene in breast cancer metastasis.
The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome.
The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks.
The relationship between motility factor receptor internalization and the lung colonization capacity of murine melanoma cells.
Topical 2'-Hydroxyflavanone for Cutaneous Melanoma.
Transgelin interacts with PARP1 in human colon cancer cells.
Uncovering synthetic lethal interactions for therapeutic targets and predictive markers in lung adenocarcinoma.
WITHDRAWN: An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer.
[Mechanism of the activation of extracellular signal-regulated kinase (ERK) in prostate cancer cell lines with different metastatic potential]
Neoplasm Micrometastasis
The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases.
Neoplasm, Residual
Major clinical research advances in gynecologic cancer in 2019.
PARP inhibitor Olaparib overcomes Sorafenib resistance through reshaping the pluripotent transcriptome in hepatocellular carcinoma.
Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor.
Neoplasms
"Lazarus Response" to Olaparib in a Virtually Chemonaive Breast Cancer Patient Carrying Gross BRCA2 Gene Deletion.
'PARP'ing fibrosis: repurposing poly (ADP ribose) polymerase (PARP) inhibitors.
(-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-?B/miR-155-5p/MDR1 Pathway.
1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma.
15-Lipoxygenase-1 induced by interleukin-4 mediates apoptosis in oral cavity cancer cells.
17?-androstenediol-mediated oncophagy of tumor cells by different mechanisms is determined by the target tumor.
18?-Glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469) inhibition of topoisomerase IIbeta is not sufficient for therapeutic response in human Waldenstrom's macroglobulinemia xenograft model.
2-[5-Selenocyanato-pentyl]-6-amino-benzo[de]isoquinoline-1,3-dione inhibits angiogenesis, induces p53 dependent mitochondrial apoptosis and enhances therapeutic efficacy of cyclophosphamide.
2D and 3D similarity landscape analysis identifies PARP as a novel off-target for the drug Vatalanib.
3,3'-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer.
3-Aminobenzamide delays rejoining of DNA strand breaks in gamma-irradiated lymphocytes from patients with breast cancer and not cervical cancer.
4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.
5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients.
5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases.
53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer.
53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
53BP1-RIF1-shieldin counteracts DSB resection through CST- and Pol?-dependent fill-in.
53BP1: a DSB escort.
6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance.
?-Catenin, a Wnt/?-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming.
?-Mangostin inhibits DMBA/TPA-induced skin cancer through inhibiting inflammation and promoting autophagy and apoptosis by regulating PI3K/Akt/mTOR signaling pathway in mice.
?-Tocotrienol-induced autophagy in malignant mammary cancer cells.
A cationic cholesterol based nanocarrier for the delivery of p53-EGFP-C3 plasmid to cancer cells.
A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors.
A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models.
A comprehensive look of poly(ADP-ribose) polymerase inhibition strategies and future directions for cancer therapy.
A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging.
A critical evaluation of methods to interpret drug combinations.
A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions.
A decade of clinical development of PARP inhibitors in perspective.
A deletion linked to a poly(ADP-ribose) polymerase gene on chromosome 13q33-qter occurs frequently in the normal black population as well as in multiple tumor DNA.
A dermatan sulfate-functionalized biomimetic nanocarrier for melanoma targeted chemotherapy.
A duplicated region is responsible for the poly(ADP-ribose) polymerase polymorphism, on chromosome 13, associated with a predisposition to cancer.
A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.
A GEMA of a personalized medicine strategy.
A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose.
A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair.
A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity.
A Homogeneous Polysaccharide from Fructus Schisandra chinensis (Turz.) Baill Induces Mitochondrial Apoptosis through the Hsp90/AKT Signalling Pathway in HepG2 Cells.
A label-free PFP-based photoelectrochemical biosensor for highly sensitive detection of PARP-1 activity.
A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.
A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer.
A meta-analysis of reversion mutations in BRCA genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistance.
A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice.
A new ADP-ribosyltransferase in human serum: significance in cancer.
A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human Cells.
A new underlying mechanism for the neuroprotective effect of bosutinib: Reverting toxicity-induced PARylation in SIN1-mediated neurotoxicity.
A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis.
A novel L-fucose-binding lectin from Fenneropenaeus indicus induced cytotoxicity in breast cancer cells.
A Novel Mechanism to Induce BRCAness in Cancer Cells.
A novel PI3K inhibitor displays potent preclinical activity against an androgen-independent and PTEN-deficient prostate cancer model established from the cell line PC3.
A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia.
A novel sLRP6E1E2 inhibits canonical Wnt signaling, epithelial-to-mesenchymal transition, and induces mitochondria-dependent apoptosis in lung cancer.
A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.
A novel synthetic derivative of the natural product berbamine inhibits cell viability and induces apoptosis of human osteosarcoma cells, associated with activation of JNK/AP-1 signaling.
A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors.
A Novel Use for Olaparib for Treatment of Metastatic Castration-Recurrent Prostate Cancer.
A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor.
A novelly synthesized phenanthroline derivative is a promising DNA-damaging anticancer agent inhibiting G1/S checkpoint transition and inducing cell apoptosis in cancer cells.
A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability.
A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis.
A PET imaging agent for evaluating PARP-1 expression in ovarian cancer.
A phase 1 study of PARP-inhibitor ABT-767 in advanced solid tumors with BRCA1/2 mutations and high-grade serous ovarian, fallopian tube, or primary peritoneal cancer.
A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors.
A Phase I Combination Study of Olaparib with Cisplatin and Gemcitabine in Adults with Solid Tumors.
A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors.
A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours.
A phase I study of the PD-L1 inhibitor, durvalumab, in combination with a PARP inhibitor, olaparib, and a VEGFR1-3 inhibitor, cediranib, in recurrent women's cancers with biomarker analyses.
A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours.
A Phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms and chronic myelomonocytic leukemia.
A Phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy in patients with advanced solid malignancies and peritoneal carcinomatosis.
A Phase I Study of Veliparib in Combination with Metronomic Cyclophosphamide in Adults with Refractory Solid Tumors and Lymphomas.
A Phase I, dose-finding and pharmacokinetic study of olaparib (AZD2281) in Japanese patients with advanced solid tumors*,†.
A Phase I-II Study of the Oral Poly(ADP-ribose) Polymerase Inhibitor Rucaparib in Patients with Germline BRCA1/2-mutated Ovarian Carcinoma or Other Solid Tumors.
A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol.
A phase II evaluation of the potent, highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who carry a germline BRCA1 or BRCA2 mutation - An NRG Oncology/Gynecologic Oncology Group study.
A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells.
A polysaccharide from Trametes robiniophila inhibits human osteosarcoma xenograft tumor growth in vivo.
A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type Tumors.
A Population Pharmacokinetic Meta-Analysis of Veliparib, a PARP Inhibitor, Across Phase 1/2/3 Trials in Cancer Patients.
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
A potential synthetic lethal strategy with PARP inhibitors: perspective on 'Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP'.
A profile on the FoundationFocus CDxBRCA tests.
A Prospective Phase II Single-arm Study of Niraparib Plus Dostarlimab in Patients With Advanced Non-small-cell Lung Cancer and/or Malignant Pleural Mesothelioma, Positive for PD-L1 Expression and Germline or Somatic Mutations in the DNA Repair Genes: Rationale and Study Design.
A Quantitative Assay Reveals Ligand Specificity of the DNA Scaffold Repair Protein XRCC1 and Efficient Disassembly of Complexes of XRCC1 and the Poly(ADP-ribose) Polymerase 1 by Poly(ADP-ribose) Glycohydrolase.
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.
A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy.
A randomized Phase II study of veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in BRCA1/2 metastatic breast cancer: design and rationale.
A review of PARP inhibitors: from bench to bedside.
A Review on DNA Repair Inhibition by PARP Inhibitors in Cancer Therapy.
A review on PARP1 inhibitors: Pharmacophore modeling, virtual and biological screening studies to identify novel PARP1 inhibitors.
A Review on Poly (ADP-ribose) Polymerase (PARP) Inhibitors and Synthetic Methodologies.
A role of intracellular mono-ADP-ribosylation in cancer biology.
A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer.
A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition.
A single nucleotide variant of human PARP1 determines response to PARP inhibitors.
A small molecule Focal Adhesion Kinase (FAK) inhibitor, targeting Y397 site: 1-(2-Hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo.
A Small-Molecule Protein-Protein Interaction Inhibitor of PARP1 That Targets Its BRCT Domain.
A snapshot of chemoresistance to PARP inhibitors.
A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin.
A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures.
A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cells.
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.
A therapeutic update on PARP inhibitors: implications in the treatment of glioma.
A transcriptomic model for homologous recombination deficiency in prostate cancer.
A triazole-conjugated benzoxazone induces reactive oxygen species and promotes autophagic apoptosis in human lung cancer cells.
A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models.
A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer.
A375 melanoma cells are sensitized to cisplatin-induced toxicity by a synthetic nitro-flavone derivative 2-(4-Nitrophenyl)-4H-chromen-4-one through inhibition of PARP1.
ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition.
Aberrant morphology, proliferation, and apoptosis of B-cell chronic lymphocytic leukemia cells.
Absence of Specific Cell Killing of the BRCA2-Deficient Human Cancer Cell Line CAPAN1 by Poly(ADP-ribose) Polymerase Inhibition.
ABT-263 induces G1/G0-phase arrest, apoptosis and autophagy in human esophageal cancer cells in vitro.
ABT-888 and quinacrine induced apoptosis in metastatic breast cancer stem cells by inhibiting base excision repair via adenomatous polyposis coli.
ABT-888 confers broad in vivo activity in combination with temozolomide in diverse tumors.
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models.
Acetylation blocks DNA damage-induced chromatin ADP-ribosylation.
Achyranthoside H methyl ester, a novel oleanolic acid saponin derivative from Achyranthes fauriei roots, induces apoptosis in human breast cancer MCF-7 and MDA-MB-453 cells via a caspase activation pathway.
Acquired multiple secondary BRCA2 mutations upon PARPi resistance in a metastatic pancreatic cancer patient harboring a BRCA2 germline mutation.
Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity.
Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression.
Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways.
Activating the Wnt/?-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3.
Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis.
Activation of caspase-3-like enzymes in non-apoptotic T cells.
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.
Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21.
Activation of poly(adenosine diphosphate-ribose) polymerase in mouse tumors treated by photodynamic therapy.
Activation of Poly(ADP-Ribose) Polymerase-1 Delays Wound Healing by Regulating Keratinocyte Migration and Production of Inflammatory Mediators.
Activation of proline metabolism maintains ATP levels during cocaine-induced polyADP-ribosylation.
Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes.
Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer.
Acute myocardial infarction induced increases in plasma tumor necrosis factor-alpha and interleukin-10 are associated with the activation of poly(ADP-ribose) polymerase of circulating mononuclear cell.
Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1.
Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF-alpha receptor 1-independent and -dependent mechanisms.
Adenosine diphosphate ribosyl transferase responses to a standardized dose of hydrogen peroxide in the mononuclear leukocytes of patients with a diagnosis of cancer.
Adenoviral-mediated transfer of the TNF-related apoptosis-inducing ligand/Apo-2 ligand gene induces tumor cell apoptosis.
Adenovirus-mediated p53 and ING4 gene co?transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer.
Adjunctive Chinese herbal medicine therapy for nasopharyngeal carcinoma: Clinical evidence and experimental validation.
Adjuvant immunotherapy of C6 glioma in rats with pertussis toxin.
Adoptive transfer of tumor-primed, in vitro-activated, CD4+ T effector cells (TEs) combined with CD8+ TEs provides intratumoral TE proliferation and synergistic antitumor response.
ADP-Ribosylation Levels and Patterns Correlate with Gene Expression and Clinical Outcomes in Ovarian Cancers.
ADP-ribosylation of the G protein Rho inhibits integrin regulation of tumor cell growth.
ADP-ribosylation of the GTP-binding protein RhoA blocks cytoplasmic division in human myelomonocytic cells.
ADP-ribosylation of wild-type p53 in vitro: binding of p53 protein to specific p53 consensus sequence prevents its modification.
ADP-ribosylation: from molecular mechanisms to human disease.
Advanced epithelial ovarian cancer: from standard chemotherapy to promising molecular pathway targets--where are we now?
Advancements in PARP1 Targeted Nuclear Imaging and Theranostic Probes.
Advances and perspectives of PARP inhibitors.
Advances in PARP inhibitors for the treatment of breast cancer.
Advances in the use of PARP inhibitor therapy for breast cancer.
Advances in the use of PARP inhibitors for BRCA1/2-associated breast cancer: talazoparib.
Advances in using PARP inhibitors to treat cancer.
Advantage of a baculovirus expression system for protein-protein interaction studies. Involvement of posttranslational phosphorylation in the interaction between wt p53 protein and poly(ADP-ribose) polymerase-1.
Aloe-emodin (AE) nanoparticles suppresses proliferation and induces apoptosis in human lung squamous carcinoma via ROS generation in vitro and in vivo.
Altered Expression of the Poly(ADP-Ribosyl)ation Enzymes in Uveal Melanoma and Regulation of PARG Gene Expression by the Transcription Factor ERM.
Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase-1 Inhibitors with Decreased P-Glycoprotein Interactions.
Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance.
Alternative mechanisms of inhibiting activity of poly (ADP-ribose) polymerase-1.
Alternative Non-Homologous End-Joining: Error-Prone DNA Repair as Cancer's Achilles' Heel.
Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell.
AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell.
Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage.
AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers.
An 18F-Labeled Poly(ADP-ribose) Polymerase Positron Emission Tomography Imaging Agent.
An Algorithm Combining Patient Performance Status, Second Hit Analysis, PROVEAN and Dann Prediction Tools Could Foretell Sensitization to PARP Inhibitors in Digestive, Skin, Ovarian and Breast Cancers.
An Analysis of Patients with DNA Repair Pathway Mutations Treated with a PARP Inhibitor.
An assessment of poly (ADP-ribose) polymerase-1 role in normal and cancer cells.
An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III? within a flexible DNA repair complex.
An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions.
An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors.
An Epstein-Barr virus positive natural killer lymphoma xenograft derived for drug testing.
An evaluation of olaparib for the treatment of pancreatic cancer.
An ex vivo assay of XRT-induced Rad51 foci formation predicts response to PARP-inhibition in ovarian cancer.
An Interaction with PARP-1 and Inhibition of Parylation Contribute to Attenuation of DNA Damage Signaling by the Adenovirus E4orf4 Protein.
An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.
An olaparib window-of-opportunity trial in patients with early-stage endometrial carcinoma: POLEN study.
An open-label, dose-escalation study to evaluate the safety and pharmacokinetics of CEP-9722 (a PARP-1 and PARP-2 inhibitor) in combination with gemcitabine and cisplatin in patients with advanced solid tumors.
An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis.
An update on PARP inhibitors for the treatment of cancer.
An update on PARP inhibitors--moving to the adjuvant setting.
An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy.
Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy.
Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients.
Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma.
Analysis of mutation status and homologous recombination deficiency in tumors of patients with germline BRCA1 or BRCA2 mutations and metastatic breast cancer: OlympiAD.
Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines.
Analysis of poly(ADP-ribose) polymerase-1 by enzyme-initiated auto-PARylation-controlled aggregation of hemin-graphene nanocomposites.
Analysis Suggests Wider Use for PARP Inhibitors.
Androgen receptor inhibitor-induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer.
Anti-androgen receptor signaling and prostate cancer inhibitory effects of sucrose- and benzophenone-compounds.
Anti-angiogenesis for cancer: Current status and prospects.
Anti-cancer action of 4-iodo-3-nitrobenzamide in combination with buthionine sulfoximine: inactivation of poly(ADP-ribose) polymerase and tumor glycolysis and the appearance of a poly(ADP-ribose) polymerase protease.
Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice.
Anti-tumor activity and the mechanism of SIP-S: A sulfated polysaccharide with anti-metastatic effect.
Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells.
Anti-tumor effect of ?-glucan from Lentinus edodes and the underlying mechanism.
Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors.
Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric G{alpha}/G{beta}{gamma} Protein Complex.
Anticancer activity of HS-527, a novel inhibitor targeting PI3-kinase in human pancreatic cancer cells.
Anticancer activity of tetrandrine by inducing pro-death apoptosis and autophagy in human gastric cancer cells.
Anticancer agents based on vulnerable components in a signalling pathway.
Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway.
Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.
Anticancer Effect of Mountain Ginseng on Human Breast Cancer: Comparison with Farm-Cultivated Ginseng.
Anticancer mechanism of equol in 7,12-dimethylbenz(a)anthracene-treated animals.
Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer.
Antimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs.
Antitumor Ability of KT2 Peptide Derived from Leukocyte Peptide of Crocodile Against Human HCT116 Colon Cancer Xenografts.
Antitumor activity of noscapine in human non-small cell lung cancer xenograft model.
Antitumor activity of RT2 peptide derived from crocodile leukocyte peptide on human colon cancer xenografts in nude mice.
Antitumor Effects and the Compatibility Mechanisms of Herb Pair Scleromitrion diffusum (Willd.) R. J. Wang-Sculellaria barbata D. Don.
Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor.
Antitumor efficacy profile of PKI-402, a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor.
Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities.
APOMAB, a La-specific monoclonal antibody, detects the apoptotic tumor response to life-prolonging and DNA-damaging chemotherapy.
Apoptosis induced by ID6105, a new anthracycline (11-hydroxyaclacinomycin X, Hyrubicin), and its anti-tumor effects on experimental tumor models.
Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response.
Apoptosis induction in lung and prostate cancer cells through silver nanoparticles synthesized from Pinus roxburghii bioactive fraction.
Apoptosis induction in prostate cancer cells and xenografts by combined treatment with Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand and CPT-11.
Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo.
Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis.
Apoptosis-related gene and protein expression in human lymphoma xenografts (Raji) after low dose rate radiation using 67Cu-2IT-BAT-Lym-1 radioimmunotherapy.
Apoptotic and anti-angiogenic effects of Pulsatilla koreana extract on hepatocellular carcinoma.
Apoptotic and antiproliferative effects of Stigmast-5-en-3-ol from Dendronephthya gigantea on human leukemia HL-60 and human breast cancer MCF-7 cells.
Apoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly(ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes.
Apoptotic and Immunosuppressive Effects of Turmeric Paste on 7, 12 Di Methyl Benz (a) Anthracene Induced Skin Tumor Model of Wistar Rat.
Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappaB survival pathway signaling.
Application and reflection of genomic scar assays in evaluating the efficacy of platinum salts and PARP inhibitors in cancer therapy.
Approaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair.
Aqueous extract of Taxus chinensis var. mairei regulates the Hippo-YAP pathway and promotes apoptosis of non-small cell lung cancer via ATF3 in vivo and in vitro.
Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.
ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors.
Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure.
Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells.
Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade.
Aspirin enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in hormone-refractory prostate cancer cells through survivin down-regulation.
ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability.
Assessment of PARP protein expression in epithelial ovarian cancer by ELISA pharmacodynamic assay and immunohistochemistry.
Assessment of PARP-1 Distribution in Tissues of Cynomolgus Monkeys.
Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of ZYTP1, a novel poly (ADP-ribose) polymerase inhibitor.
Assessment of the Inhibitory Effects of Ficin-hydrolyzed Gelatin Derived from Squid (Uroteuthis duvauceli) on Breast Cancer Cell Lines and Animal Model.
Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis.
Association between the PARP1 Val762Ala polymorphism and cancer risk: evidence from 43 studies.
Association of PARP-1, NF-?B, NF-?BIA and IL-6, IL-1? and TNF-? with Graves Disease and Graves Ophthalmopathy.
Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes.
Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population.
Association of T2285C polymorphism in PARP1 gene coding region with its expression, activity and NSCLC risk along with prognosis.
ATARI trial: ATR inhibitor in combination with olaparib in gynecological cancers with ARID1A loss or no loss (ENGOT/GYN1/NCRI).
ATM deficiency is associated with sensitivity to PARP1 and ATR inhibitors in lung adenocarcinoma.
ATM deficiency promotes progression of CRPC by enhancing Warburg effect.
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications.
ATM in DNA repair in cancer.
ATM Loss Confers Greater Sensitivity to ATR Inhibition than PARP Inhibition in Prostate Cancer.
ATM-Deficient Cancers Provide New Opportunities for Precision Oncology.
ATM-Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions.
ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition.
ATMIN Suppresses Metastasis by Altering the WNT-Signaling Pathway via PARP1 in MSI-High Colorectal Cancer.
ATR addiction in multiple myeloma: synthetic lethal approaches exploiting established therapies.
ATR inhibition amplifies antitumor effects of olaparib in biliary tract cancer.
ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.
ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells.
Attenuation of SRC Kinase Activity Augments PARP Inhibitor-mediated Synthetic Lethality in BRCA2-altered Prostate Tumors.
Augmentation of tumor necrosis factor-alpha-induced monocytic differentiation of a myelomonocytic leukemia (WEHI-3B JCS) by pertussis toxin.
Auriculasin-induced ROS causes prostate cancer cell death via induction of apoptosis.
Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells.
Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.
Autocrine motility factor is a growth factor.
Autoimmune response to PARP and BRCA1/BRCA2 in cancer.
Autophagy in the physiological endometrium and cancer.
Autophagy suppression enhances DNA damage and cell death upon treatment with PARP inhibitor Niraparib in laryngeal squamous cell carcinoma.
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.
Avicularin reversed multidrug-resistance in human gastric cancer through enhancing Bax and BOK expressions.
Avoid the trap: Targeting PARP1 beyond human malignancy.
AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers.
Azoxystrobin Induces Apoptosis of Human Esophageal Squamous Cell Carcinoma KYSE-150 Cells through Triggering of the Mitochondrial Pathway.
B-lymphoblastic leukemia/lymphoma: overexpression of nuclear DNA repair protein PARP-1 correlates with antiapoptotic protein Bcl-2 and complex chromosomal abnormalities.
Baicalein attenuates proteasome inhibition-induced apoptosis by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways.
Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest.
BAP1-Altered Malignant Pleural Mesothelioma: Outcomes With Chemotherapy, Immune Check-Point Inhibitors and Poly(ADP-Ribose) Polymerase Inhibitors.
BAP1: Not just a BRCA1-associated protein.
BARD1 homozygous deletion, a possible alternative to BRCA1 mutation in basal breast cancer.
Base excision repair imbalance in colorectal cancer has prognostic value and modulates response to chemotherapy.
Base excision repair pathway: PARP1 genotypes as modulators of therapy response in cervical cancer patients.
Base excision repair, the redox environment and therapeutic implications.
Baseline sister chromatid exchange in human cell lines with different levels of poly(ADP-ribose) polymerase.
BAX Redistribution Induces Apoptosis Resistance and Selective Stress Sensitivity in Human HCC.
Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain.
Bcl-2/Bcl-xL Inhibition Increases the Efficacy of Mek Inhibition Alone and in Combination with PI3 Kinase Inhibition in Lung and Pancreatic Tumor Models.
Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells.
Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor.
Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition.
BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer.
Beyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated and BRCA-Like Solid Tumors.
Beyond DNA Repair: Additional Functions of PARP-1 in Cancer.
Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS.
Biasing human epidermal growth factor receptor 4 (HER4) tyrosine kinase signaling with antibodies: Induction of cell death by antibody-dependent HER4 intracellular domain trafficking.
Biliary tract cancer and genomic alterations in homologous recombinant deficiency: exploiting synthetic lethality with PARP inhibitors.
Bioinformatic Analysis of the Nicotinamide Binding Site in Poly(ADP-Ribose) Polymerase Family Proteins.
Biological and clinical significance of PARP1 protein expression in breast cancer.
Biological characterization of bovine mammary epithelial cell lines immortalized by HPV16 E6/E7 and SV40T.
Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance.
Biomarker-driven and molecularly targeted therapies for pancreatic adenocarcinoma.
Biomarker-Guided Development of DNA Repair Inhibitors.
Biomarkers for Homologous Recombination Deficiency in Cancer.
Biomarkers of drug resistance in ovarian cancer - an update.
Biomarkers predicting clinical benefit: fact or fiction?
Biosynthesized composites of Au-Ag nanoparticles using Trapa peel extract induced ROS-mediated p53 independent apoptosis in cancer cells.
Biphasic reduction of histone H3 phosphorylation in response to N-nitroso compounds induced DNA damage.
Bisphosphonates may reduce recurrence in giant cell tumor by inducing apoptosis.
Bivalent smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents.
BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression.
BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair.
Black Tea: Phytochemicals, Cancer Chemoprevention and Clinical Studies.
Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo.
Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.
Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells.
Bone marrow PARP1 mRNA levels predict response to treatment with 5-azacytidine in patients with myelodysplastic syndrome.
Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor-?B activity in human oral cancer cells.
Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors.
Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and Prognosis.
BRCA 1/2-Mutation Related and Sporadic Breast and Ovarian Cancers: More Alike than Different.
BRCA Gene Mutations and Poly(ADP-Ribose) Polymerase Inhibitors in Triple-Negative Breast Cancer.
BRCA in breast cancer: from risk assessment to therapeutic prediction.
BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives.
BRCA mutations and gastrointestinal cancers: When to expect the unexpected?
BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.
BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance.
BRCA1 alterations with additional defects in DNA damage response genes may confer chemoresistance to BRCA-like breast cancers treated with neoadjuvant chemotherapy.
BRCA1 and BARD1 colocalize mainly in the cytoplasm of breast cancer tumors, and their isoforms show differential expression.
BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.
BRCA1 deficiency and synthetic lethality in leukemias; not only gene mutation matters.
BRCA1 deficiency is a recurrent event in early-onset triple-negative breast cancer: a comprehensive analysis of germline mutations and somatic promoter methylation.
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
BRCA1 Mutations in Cancer: Coordinating Deficiencies in Homologous Recombination with Tumorigenesis.
BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer.
BRCA1 Promoter Methylation Is Linked to Defective Homologous Recombination Repair and Elevated miR-155 to Disrupt Myeloid Differentiation in Myeloid Malignancies.
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.
BRCA1, PARP1 and ?H2AX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparib.
BRCA1- and BRCA2-related mutations: therapeutic implications in ovarian cancer.
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1.
BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors.
BRCA2 Deletion Induces Alternative Lengthening of Telomeres in Telomerase Positive Colon Cancer Cells.
BRCA2 secondary mutation-mediated resistance to platinum and PARP inhibitor-based therapy in pancreatic cancer.
BRCA2-Deficient CAPAN-1 Cells are Extremely Sensitive to the Inhibition of Poly (ADP-Ribose) Polymerase: An Issue of Potency.
BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance.
BRCAness and Prognosis in Triple-Negative Breast Cancer Patients Treated with Neoadjuvant Chemotherapy.
BRCAness and prostate cancer: diagnostic and therapeutic considerations.
BRCAness: finding the Achilles heel in ovarian cancer.
BRD4 Inhibitor AZD5153 Suppresses the Proliferation of Colorectal Cancer Cells and Sensitizes the Anticancer Effect of PARP Inhibitor.
Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumors.
Breast cancer in BRCA mutation carriers: medical treatment.
Breast Cancer in BRCA1/2 Mutation Carriers - Do We Treat It Differently? Focus on Systemic Therapy for BRCA1/2 Associated Breast Cancer.
Breast Cancer Predisposition Genes and Synthetic Lethality.
Breast cancer.
Breviscapine (BVP) inhibits prostate cancer progression through damaging DNA by minichromosome maintenance protein-7 (MCM-7) modulation.
Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.
Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation.
c-MYC Suppresses BIN1 to Release Poly(ADP-Ribose) Polymerase 1: A Mechanism by Which Cancer Cells Acquire Cisplatin Resistance.
Cadmium and cancer.
Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation.
Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair.
Can integrative biomarker approaches improve prediction of platinum and PARP inhibitor response in ovarian cancer?
Can Poly (ADP-Ribose) Polymerase Inhibitors Palliate Paclitaxel-Induced Peripheral Neuropathy in Patients With Cancer?
Cancer biomarkers for targeted therapy.
Cancer during pregnancy alters the activity of rat placenta and enhances the expression of cleaved PARP, cytochrome-c and caspase 3.
Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimer's Disease.
Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes.
Candidate synthetic lethality partners to PARP inhibitors in the treatment of ovarian clear cell cancer.
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Capitalizing on Cancer Replication Stress by Preventing PAR Chain Turnover: A New Type of Synthetic Lethality.
Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway.
Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition.
Cardiomyocyte death in patients with end-stage heart failure before and after support with a left ventricular assist device: low incidence of apoptosis despite ubiquitous mediators.
Casein kinase 2 inhibition attenuates cholesterol oxidation product-induced apoptosis by suppressing the activation of the mitochondrial pathway and the caspase-8- and bid-dependent pathways.
Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis.
Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria.
Castalagin and vescalagin purified from leaves of Syzygium samarangense (Blume) Merrill & L.M. Perry: Dual inhibitory activity against PARP1 and DNA topoisomerase II.
Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells.
Catalase Abrogates ?-Lapachone-Induced PARP1 Hyperactivation-Directed Programmed Necrosis in NQO1-Positive Breast Cancers.
Cationic liposome codelivering PI3K pathway regulator improves the response of BRCA1-deficient breast cancer cells to PARP1 inhibition.
Causing DNA damage and stopping DNA repair - Vitamin D supplementation with Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors may cause selective cell death of cancer cells: A novel therapeutic paradigm utilizing elevated copper levels within the tumour.
CBP-Mediated FOXO-1 Acetylation Inhibits Pancreatic Tumor Growth by Targeting SirT.
CCDC6: the identity of a protein known to be partner in fusion.
CCNE1 Is a Putative Therapeutic Target for ARID1A-Mutated Ovarian Clear Cell Carcinoma.
CD40- and HLA-DR-mediated cell death pathways share a lot of similarities but differ in their use of ADP-ribosyltransferase activities.
CDK1 promotes nascent DNA synthesis and induces resistance of cancer cells to DNA-damaging therapeutic agents.
CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.
CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.
Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51.
Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9.
Celebrating the 80th anniversary of hormone ablation for prostate cancer.
Cell Cycle Resolved Measurements of Poly(ADP-Ribose) Formation and DNA Damage Signaling by Quantitative Image-Based Cytometry.
Cell death associated with abnormal mitosis observed by confocal imaging in live cancer cells.
Cell death in cancer in the era of precision medicine.
Cell death protection by 3-aminobenzamide: impairment of cytoskeleton function in human NK cell-mediated killing.
Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING.
Central and carboxy-terminal regions of human p53 protein are essential for interaction and complex formation with PARP-1.
Cepharanthine combined with 5-fluorouracil inhibits the growth of p53-mutant human colorectal cancer cells.
Ceralasertib-Mediated ATR Inhibition Combined With Olaparib in Advanced Cancers Harboring DNA Damage Response and Repair Alterations (Olaparib Combinations).
Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells.
Cetuximab augments cytotoxicity with poly (adp-ribose) polymerase inhibition in head and neck cancer.
Characterisation of Deubiquitylating Enzymes in the Cellular Response to High-LET Ionizing Radiation and Complex DNA Damage.
Characterization and anti-tumor activity of saponin-rich fractions of South Korean sea cucumbers (Apostichopus japonicus).
Characterization of human chorionic gonadotropin as a novel angiogenic factor.
Characterization of transcriptomic signature of primary prostate cancer analogous to prostatic small cell neuroendocrine carcinoma.
Characterization, Detection, and Treatment Approaches for Homologous Recombination Deficiency in Cancer.
Chemopotentiation by PARP inhibitors in cancer therapy.
Chemoprevention of hormone receptor-negative breast cancer: new approaches needed.
Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice.
Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.
Chemotherapy for Patients with BRCA1 and BRCA2-Mutated Ovarian Cancer: Same or Different?
Chemotherapy reduces PARP1 in cancers of the ovary: implications for future clinical trials involving PARP inhibitors.
Chemotherapy-induced p53-dependent and -independent DNA damage responses are enhanced by poly(ADP-ribose) polymerase (PARP) inhibition in BRCA-proficient cancer cells.
CHFR regulates the mitotic checkpoint by targeting PARP-1 for ubiquitination and degradation.
CHIR-258: a potent inhibitor of FLT3 kinase in experimental tumor xenograft models of human acute myelogenous leukemia.
Chitosan-Dextran sulfate coated doxorubicin loaded PLGA-PVA-nanoparticles caused apoptosis in doxorubicin resistance breast cancer cells through induction of DNA damage.
CHK2 Inhibition Provides a Strategy to Suppress Hematologic Toxicity from PARP Inhibitors.
Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.
Chromatin (dis)organization and cancer: BUR-binding proteins as biomarkers for cancer.
Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function.
Circulating HOXA9-methylated tumour DNA: A novel biomarker of response to poly (ADP-ribose) polymerase inhibition in BRCA-mutated epithelial ovarian cancer.
cis-[RuCl(BzCN) (bipy) (dppe)]PF6 induces anti-angiogenesis and apoptosis by a mechanism of caspase-dependent involving DNA damage, PARP activation, and Tp53 induction in Ehrlich tumor cells.
Cisplatin induces primary necrosis through poly(ADP-ribose) polymerase 1 activation in kidney proximal tubular cells.
Cisplatin Resistance and Redox-Metabolic Vulnerability: A Second Alteration.
Cisplatin resistance associated with PARP hyperactivation.
Cisplatin resistance coupled to enhanced sensitivity to metabolic interventions.
Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage.
ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma.
Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia.
Cleavage of Poly(ADP-ribose) polymerase measured in situ in individual cells: relationship to DNA fragmentation and cell cycle position during apoptosis.
Cleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatment with N-nitrosomorpholine and cyproterone acetate.
Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas.
Clinical Application of Poly(ADP-Ribose) Polymerase Inhibitors in High-Grade Serous Ovarian Cancer.
Clinical Development of PARP Inhibitors in Treating Metastatic Castration-Resistant Prostate Cancer.
Clinical factors of response in patients with advanced ovarian cancer participating in early phase clinical trials.
Clinical management of hereditary breast cancer syndromes.
Clinical perspectives of PARP inhibitors.
Clinical Pharmacokinetics and Mass Balance of Veliparib in Combination with Temozolomide in Subjects with Nonhematologic Malignancies.
Clinical poly(ADP-ribose) polymerase inhibitors for the treatment of cancer.
Clinical practice guidelines for BRCA1 and BRCA2 genetic testing.
Clinical Significance of Tumor Infiltrating Lymphocytes in Association with Hormone Receptor Expression Patterns in Epithelial Ovarian Cancer.
Clinical Stratification of High-Grade Ovarian Serous Carcinoma Using a Panel of Six Biomarkers.
Clinical trials and future potential of targeted therapy for ovarian cancer.
Clinical Trials of Poly(ADP-Ribose) Polymerase Inhibitors for Cancer Therapy: A Review.
Clinical use and mechanisms of resistance for PARP inhibitors in homologous recombination-deficient cancers.
Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo.
Cloricromene, a coumarine derivative, reduced the development of periodontitis in rats.
Co-regulated expression of dbl and poly(ADP-ribose) polymerase in Ewing's sarcoma cells and dbl-transformed NIH3T3 fibroblasts.
Co-targeting poly(ADP-ribose) polymerase (PARP) and histone deacetylase (HDAC) in triple-negative breast cancer: Higher synergism in BRCA mutated cells.
Colorectal cancers differ in respect of PARP-1 protein expression.
Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin.
Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells.
Combination of erlotinib and a PARP inhibitor inhibits growth of A2780 tumor xenografts due to increased autophagy.
Combination of photoactive hypericin and Manumycin A exerts multiple anticancer effects on oxaliplatin-resistant colorectal cells.
Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer.
Combination Platinum-based and DNA Damage Response-targeting Cancer Therapy: Evolution and Future Directions.
Combination therapy in advanced urothelial cancer: the role of PARP, HER-2 and mTOR inhibitors.
Combination Therapy With Charged Particles and Molecular Targeting: A Promising Avenue to Overcome Radioresistance.
Combination therapy with dacarbazine and statins improved the survival rate in mice with metastatic melanoma.
Combination Therapy with Radiation and PARP Inhibition Enhances Responsiveness to Anti-PD-1 Therapy in Colorectal Tumor Models.
Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer.
Combination treatment with auranofin and nutlin-3a induces synergistic cytotoxicity in breast cancer cells.
Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma.
Combinations of PARP, hedgehog and HDAC inhibitors with standard drugs.
Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination-Proficient Pancreatic Cancer.
Combinatorial therapy of immune checkpoint and cancer pathways provides a novel perspective on ovarian cancer treatment.
Combined Effect of Hsp90 Inhibitor Geldanamycin and Parthenolide via Reactive Oxygen Species-Mediated Apoptotic Process on Epithelial Ovarian Cancer Cells.
Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells.
Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes.
Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells.
Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors.
Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells.
Combined Strategies with Poly (ADP-Ribose) Polymerase (PARP) Inhibitors for the Treatment of Ovarian Cancer: A Literature Review.
Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress.
Combined Treatment Modalities for High-Energy Proton Irradiation: Exploiting Specific DNA Repair Dependencies.
Combined treatment with auranofin and trametinib induces synergistic apoptosis in breast cancer cells.
Combined treatment with PI3K inhibitor BKM120 and PARP inhibitor olaparib is effective in inhibiting the gastric cancer cells with ARID1A deficiency.
Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site.
Combined tumor sequencing and case/control analyses of RAD51C in breast cancer.
Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors.
Combining PARP Inhibition with Platinum, Ruthenium or Gold Complexes for Cancer Therapy.
Combining PARP inhibition, radiation, and immunotherapy: A possible strategy to improve the treatment of cancer?
Combining poly(ADP-ribose) polymerase 1 (PARP-1) inhibition and radiation in Ewings sarcoma results in lethal DNA damage.
Combining poly(ADP-ribose) polymerase inhibitors and immune checkpoint inhibitors in breast cancer: rationale and preliminary clinical results.
Comparative antiproliferative effects of iniparib and olaparib on a panel of triple-negative and non-triple-negative breast cancer cell lines.
Comparative Assessment of Diagnostic Homologous Recombination Deficiency-Associated Mutational Signatures in Ovarian Cancer.
Comparative inhibitory profile and distribution of bacterial PARPs, using Clostridioides difficile CD160 PARP as a model.
Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer.
Comparative safety and tolerability of approved PARP inhibitors in cancer: A systematic review and network meta-analysis.
Comparative status of activated ERK1/2 and PARP cleavage in human gliomas.
Comparing mutation frequencies for homologous recombination genes in uterine serous and high-grade serous ovarian carcinomas: A case for homologous recombination deficiency testing in uterine serous carcinoma.
Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.
Complete pathological response to olaparib and bevacizumab in advanced cervical cancer following chemoradiation in a BRCA1 mutation carrier: a case report.
Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis.
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.
Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets.
Computational investigation of FDA approved drugs as selective PARP-1 inhibitors by targeting BRCT domain for cancer therapy.
Concordance of ATM (Ataxia Telangiectasia Mutated) Immunohistochemistry between Biopsy or Metastatic Tumor Samples and Primary Tumors in Gastric Cancer Patients.
Consumer Beware: A Systematic Assessment of Potential Bias in the Lay Electronic Media to Examine the Portrayal of "PARP" Inhibitors for Cancer Treatment.
Contemporary prognostic indicators for prostate cancer incorporating International Society of Urological Pathology recommendations.
Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment.
Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells.
Contributions of PARP-1 rs1136410 C>T polymorphism to the development of cancer.
Converting cancer mutations into therapeutic opportunities.
Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice.
Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function.
Coordination of DNA mismatch repair and base excision repair processing of chemotherapy and radiation damage for targeting resistant cancers.
Copper-Mediated Radiosynthesis of [18F]Rucaparib.
Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP.
Correction: Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations.
Correction: PARP-1 inhibitor modulate ?-catenin signaling to enhance cisplatin sensitivity in cancer cervix.
Correction: Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program.
Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors.
Coxiella burnetii inhibits apoptosis in human THP-1 cells and monkey primary alveolar macrophages.
CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice.
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.
CRISPR Screens in Synthetic Lethality and Combinatorial Therapies for Cancer.
CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in BRCA1-mutated breast cancer cells.
CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high grade serous carcinoma.
Critical role for BRCA1 expression as a marker of chemosensitivity response and prognosis.
Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells.
Crossroads of telomere biology and anticancer drug discovery.
Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia.
Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer.
Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2.
CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer.
Cucurbitacins as inducers of cell death and a rich source of potential anticancer compounds.
CUDC-907 enhances TRAIL-induced apoptosis through upregulation of DR5 in breast cancer cells.
Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity.
Curcumin Combined with Oxaliplatin Effectively Suppress Colorectal Carcinoma in vivo Through Inducing Apoptosis.
Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells.
Curcumin inhibits PhIP induced cytotoxicity in breast epithelial cells through multiple molecular targets.
Curcumin Nicotinate Selectively Induces Cancer Cell Apoptosis and Cycle Arrest through a P53-Mediated Mechanism.
Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor.
Curcumin targets the AKT-mTOR pathway for uterine leiomyosarcoma tumor growth suppression.
Current and Future Directions for PARP Inhibition.
Current and future landscape of poly (ADP-ribose) polymerase inhibition resistance.
Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology.
Current status and future prospects of PARP inhibitor clinical trials in ovarian cancer.
Current Strategies and Novel Therapeutic Approaches for Metastatic Urothelial Carcinoma.
Current Systemic Treatment Landscape of Advanced Gynecologic Malignancies.
Current treatment landscape and emerging therapies for pancreatic cancer.
Current Treatment Options in Triple Negative Breast Cancer.
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
CX-5461 sensitises DNA damage repair proficient castrate-resistant prostate cancer to PARP inhibition.
Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells.
Cyclin A2 regulates homologous recombination DNA repair and sensitivity to DNA damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors in human breast cancer cells.
Cyclin D1 silencing impairs DNA double strand break repair, sensitizes BRCA1 wildtype ovarian cancer cells to olaparib.
Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line.
Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells.
Cytoplasmic ADP-ribosylation levels correlate with markers of patient outcome in distinct human cancers.
Cytoplasmic EBP50 and elevated PARP1 are unfavorable prognostic factors in ovarian clear cell carcinoma.
Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts.
Cytotoxic and apoptotic effects of heat killed Mycobacterium indicus pranii (MIP) on various human cancer cell lines.
Cytotoxic and targeted therapy for BRCA1/2-driven cancers.
Cytotoxic and targeted therapy for hereditary cancers.
Cytotoxic gold compounds: synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1.
Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways.
Cytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC.
Cytotoxicity and Differentiating Effect of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib in Myelodysplastic Syndromes.
Cytotoxicity and genotoxicity induced in vitro by solvent-extractable organic matter of size-segregated urban particulate matter.
Cytotoxicity and Pro-Apoptotic, Antioxidant and Anti-Inflammatory Activities of Geopropolis Produced by the Stingless Bee Melipona fasciculata Smith.
Cytotoxicity of lapachol, ?-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells.
Daphnane Diterpenoids from Daphne genkwa Inhibit PI3K/Akt/mTOR Signaling and Induce Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells.
DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors.
Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.
Deciphering the Insights of Poly(ADP-Ribosylation) in Tumor Progression.
Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1.
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
Defective DNA repair mechanisms in prostate cancer: impact of olaparib.
Defective homologous recombination in human cancers.
Defects in HR repair behind the human diseases: FA and HBOC.
Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition.
Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints.
Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability.
Delayed role of tumor necrosis factor- alpha in overcoming the effects of pertussis toxin.
Deleterious somatic variants in 473 consecutive individuals with ovarian cancer: results of the observational AGO-TR1 study (NCT02222883).
Delving into PARP inhibition from bench to bedside and back.
Deoxypodophyllotoxin triggers parthanatos in glioma cells via induction of excessive ROS.
Dependence of trans-ADP-ribosylation and nuclear glycolysis on the Arg 34-ATP complex of Zn2+ finger I of poly-ADP-ribose polymerase-1.
Design and Synthesis of DNA-Interactive ?-Carboline-Oxindole Hybrids as Cytotoxic and Apoptosis-Inducing Agents.
Design, synthesis and anticancer activities of novel dual poly(ADP-ribose) polymerase-1/histone deacetylase-1 inhibitors.
Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA.
Design, synthesis and biological activity of novel molecules designed to target PARP and DNA.
Design, synthesis and biological evaluation of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer therapy.
Design, synthesis and biological evaluation of cinnamic acyl shikonin derivatives.
Design, synthesis and biological evaluation of erythrina derivatives bearing a 1,2,3-triazole moiety as PARP-1 inhibitors.
Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors.
Design, synthesis and biological evaluation of novel 5-fluoro-1H-benzimidazole-4-carboxamide derivatives as potent PARP-1 inhibitors.
Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent.
Detection and Delineation of Oral Cancer With a PARP1-Targeted Optical Imaging Agent.
Detection of Molecular Signatures of Homologous Recombination Deficiency in Bladder Cancer.
Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors.
Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a
Development and validation of a high-performance liquid chromatography method for the quantitation of intracellular PARP inhibitor Olaparib in cancer cells.
Development and validation of high-throughput screening assays for poly(ADP-ribose) polymerase-2 inhibitors.
Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer.
Development of a Cationic Amphiphilic Helical Peptidomimetic (B18L) As A Novel Anti-Cancer Drug Lead.
Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.
Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors.
Development of breast tumors in CHEK2, NBN/NBS1 and BLM mutation carriers does not commonly involve somatic inactivation of the wild-type allele.
Development of PARP and Immune-Checkpoint Inhibitor Combinations.
Development of PARP inhibitor combinations for castration resistant prostate cancer unselected for homologous recombination repair mutations.
Development of PARP inhibitors in gynecological malignancies.
Development of PARP inhibitors in oncology.
Development of poly(ADP-ribose) polymerase inhibitors in the treatment of BRCA-mutated breast cancer.
Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells.
Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice.
Dietary fish oil deactivates a growth-promoting signaling pathway in hepatoma 7288CTC in Buffalo rats.
Differences in the cellular response and signaling pathways of cisplatin and BBR3464 ([[trans-PtCl(NH3)(2)]2mu-(trans-Pt(NH3)(2)(H2N(CH2)(6)-NH2)2)]4+) influenced by copper homeostasis.
Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival.
Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination.
Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.
Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus.
Differential expression of Ia by murine keratinocytes and gut epithelium in response to recombinant gamma-interferon.
Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells.
Differential induction of apoptosis and MAP kinase signaling by mitochondrial toxicants in drug-sensitive compared to drug-resistant B-lineage lymphoid cell lines.
Differential radiosensitization by the poly(ADP-ribose) transferase inhibitor 3-aminobenzamide in human tumor cells of varying radiosensitivity.
Differential regulation of breast cancer bone metastasis by PARP1 and PARP2.
Differential therapeutic effects of PARP and ATR inhibition combined with radiotherapy in the treatment of subcutaneous versus orthotopic lung tumour models.
Differentiation-Associated Downregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Myoblasts Serves to Increase Their Resistance to Oxidative Stress.
Dihomo-?-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Direct current electrical fields induce apoptosis in oral mucosa cancer cells by NADPH oxidase-derived reactive oxygen species.
Directed therapy of subtypes of triple-negative breast cancer.
Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.
Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer.
Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.
Discovery and SAR study of 2-(1-propylpiperidin-4-yl)-3H-imidazo[4,5-c]pyridine-7-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) for the treatment of cancer.
Discovery and Structure-Activity Relationships of Modified Salicylanilides as Cell Permeable Inhibitors of Poly(ADP-ribose) Glycohydrolase (PARG).
Discovery of 2-(1-(3-(4-Chloroxyphenyl)-3-oxo- propyl)pyrrolidine-3-yl)-1H-benzo[d]imidazole-4-carboxamide: A Potent Poly(ADP-ribose) Polymerase (PARP) Inhibitor for Treatment of Cancer.
Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy.
Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors.
Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties.
Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers.
Discovery of naphthacemycins as a novel class of PARP1 inhibitors.
Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity.
Discovery of novel and potent PARP/PI3K dual inhibitors for the treatment of cancer.
Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer.
Discovery of Novel Bromophenol-Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer.
Discovery of Novel Dual Poly(ADP-ribose)polymerase and Phosphoinositide 3-Kinase Inhibitors as a Promising Strategy for Cancer Therapy.
Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development.
Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy.
Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers.
Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515.
Discovery of the PARP (poly ADP-ribose polymerase) inhibitor 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide for the treatment of cancer.
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.
Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy.
Discriminating radiation injury from recurrent tumor with [18F]PARPi and amino acid PET in mouse models.
Discussion of PARP inhibitors in cancer therapy.
DISPOSITION AND DRUG-DRUG INTERACTION POTENTIAL OF VELIPARIB (ABT-888), A NOVEL AND POTENT INHIBITOR OF POLY(ADP-RIBOSE) POLYMERASE.
Disrupting Na(+),HCO3(-)-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development.
Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice.
Disulfide Cleavage in a Dimeric Epipolythiodioxopiperazine Natural Product Diminishes Its Apoptosis-Inducing Effect but Enhances Autophagy in Tumor Cells.
Disulfiram combined with copper induces immunosuppression via PD-L1 stabilization in hepatocellular carcinoma.
DNA Damage Repair Alterations are Frequent in Prostatic Adenocarcinomas with Focal Pleomorphic Giant Cell Features.
DNA Damage Repair and the Emerging Role of Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapeutics.
DNA damage repair functions and targeted treatment in breast cancer.
DNA damage response as a therapeutic target in gynecological cancers.
DNA damage response genes and the development of cancer metastasis.
DNA damage response markers are differentially expressed in BRCA-mutated breast cancers.
DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer.
DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma.
DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity.
DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.
DNA repair deficiency as a therapeutic target in cancer.
DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy.
DNA Repair Deficiency Is Common in Advanced Prostate Cancer: New Therapeutic Opportunities.
DNA repair factors and telomere-chromosome integrity in mammalian cells.
DNA Repair Gene Alterations and PARP Inhibitor Response in Patients With Metastatic Castration-Resistant Prostate Cancer.
DNA repair genes are selectively mutated in diffuse large B cell lymphomas.
DNA repair genes polymorphisms and genetic susceptibility to Philadelphia-negative myeloproliferative neoplasms in a Portuguese population: The role of base excision repair genes polymorphisms.
DNA Repair in Prostate Cancer: Biology and Clinical Implications.
DNA repair proteins as therapeutic targets in ovarian cancer.
DNA repair signature is associated with anthracycline response in triple negative breast cancer patients.
DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study.
DNA Repair.
DNA replication stress and emerging prospects for PARG inhibitors in ovarian cancer therapy.
DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.
DNA-binding properties of poly(ADP-ribose) polymerase: a target for anticancer therapy.
DNA-Damaging Anticancer Drugs - a Perspective for DNA Repair-Oriented Therapy.
DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.
DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?
Does the Poly (ADP-Ribose) Polymerase Inhibitor Veliparib Merit Further Study for Cancer-Associated Weight Loss? Observations and Conclusions from Sixty Prospectively Treated Patients.
Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol.
Dose-dependent study of effects of 532-nm continuous wave laser on rat skin: A mechanistic insight.
Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy.
Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer.
Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells.
Down-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma.
Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non?small cell lung cancer.
Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair.
Doxorubicin enhances Snail/LSD1-mediated PTEN suppression in a PARP1-dependent manner.
Doxorubicin-mediated apoptosis in glioma cells requires NFAT3.
Drug conjugation to hyaluronan widens therapeutic indications for ovarian cancer.
Drug Driven Synthetic Lethality: bypassing tumor cell genetics with a combination of Dbait and PARP inhibitors.
Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells.
Drug repurposing studies of PARP inhibitors as a new therapy for inherited retinal degeneration.
Drug Target Strategies in Breast Cancer Treatment: Recent Developments.
Drug-induced xenogenization of tumors: A possible role in the immune control of malignant cell growth in the brain?
Drugging the Cancers Addicted to DNA Repair.
Drugging topoisomerases: lessons and challenges.
Drugs interfering with apoptosis in breast cancer.
Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells.
Dual roles of PARP-1 promote cancer growth and progression.
Dual Targeting of ERBB2/ERBB3 for the Treatment of SLC3A2-NRG1-Mediated Lung Cancer.
Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma.
Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages.
Editorial: Inhibiting PARP as a Strategic Target in Cancer.
Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells.
Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines.
Effect of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in patients with colorectal cancer.
Effect of curcumin on irradiated and estrogen-transformed human breast cell lines.
Effect of hyperthermia and chemotherapeutic agents on TRAIL-induced cell death in human colon cancer cells.
Effect of mitochondrially targeted carboxy proxyl nitroxide on Akt-mediated survival in Daudi cells: Significance of a dual mode of action.
Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro.
Effect of niraparib on cardiac repolarization in patients with platinum-sensitive, recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer.
Effect of poly(ADP-ribose)polymerase and DNA topoisomerase I inhibitors on the p53/p63-dependent survival of carcinoma cells.
Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: A systematic review and meta-analysis.
Effects of cardiotoxin III on NF-kappaB function, proliferation, and apoptosis in human breast MCF-7 cancer cells.
Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts.
Effects of long-term dehydration on oxidative stress, apoptotic markers and neuropeptides in the gastric mucosa of the dromedary camel.
Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.
Effects of PARP inhibition on drug and Fas-induced apoptosis in leukaemic cells.
Effects of poly (ADP-ribose) polymerase-1 (PARP-1) inhibition on sulfur mustard-induced cutaneous injuries in vitro and in vivo.
Effects of poly(ADP-ribose) polymerase inhibition on cell death and chromosome damage induced by VP16 and bleomycin.
Effects of veliparib on microglial activation and functional outcomes following traumatic brain injury in the rat and pig.
Effects on apoptosis and cell cycle arrest contribute to the antitumor responses of interleukin-27 mediated by retrovirus in human pancreatic carcinoma cells.
Efficacy and safety of anti-PD-1-based therapy in combination with PARP inhibitors for patients with advanced solid tumors in a real-world setting.
Efficacy of PARP inhibition combined with EZH2 inhibition depends on BRCA mutation status and microenvironment in breast cancer.
Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib.
Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein.
Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy.
EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma.
EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma.
EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork-Associated DNA Damage Repair.
Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors.
Elevated poly-(ADP-ribose)-polymerase activity sensitizes retinoblastoma-deficient cells to DNA damage-induced necrosis.
Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models.
Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice.
Embelin Suppresses Growth of Human Pancreatic Cancer Xenografts, and Pancreatic Cancer Cells Isolated from KrasG12D Mice by Inhibiting Akt and Sonic Hedgehog Pathways.
Embracing synthetic lethality of novel anticancer therapies.
Emerging drugs for the treatment of ovarian cancer: a focused review of PARP inhibitors.
Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells.
Endotoxin tolerance impairs a pertussis-toxin-sensitive G-protein regulating tumour necrosis factor release by macrophages from tumour-bearing rats.
Endpoint of cancer treatment: targeted therapies.
Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells.
Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53.
Enhanced Efficacy of Combined Therapy with Checkpoint Kinase 1 Inhibitor and Rucaparib Via Regulation of Rad-51 Expression in BRCA Wild-Type Epithelial Ovarian Cancer Cells.
Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.
Enhanced poly ADP-ribosylation in human leukemia lymphocytes and ovarian cancers.
Enhanced polyadenosine diphosphate-ribosylation in gonadotropin-releasing hormone agonist-treated uterine leiomyoma.
Enhanced suppression of proliferation and migration in highly-metastatic lung cancer cells by combination of valproic acid and coumarin-3-carboxylic acid and its molecular mechanisms of action.
Enhancement of Cytotoxicity and Inhibition of Angiogenesis in Oral Cancer Stem Cells by a Hybrid Nanoparticle of Bioactive Quinacrine and Silver: Implication of Base Excision Repair Cascade.
Enhancement of Synthetic Lethality via Combinations of ABT-888, a PARP Inhibitor, and Carboplatin In Vitro and In Vivo Using BRCA1 and BRCA2 Isogenic Models.
Enhancing the anti-tumour activity of 177Lu-DOTA-octreotate radionuclide therapy in somatostatin receptor-2 expressing tumour models by targeting PARP.
Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer.
Enhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors.
Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Epigallocatechin gallate (EGCG) suppresses growth and tumorigenicity in breast cancer cells by downregulation of miR-25.
Epigenetic activation of HORMAD1 in basal-like breast cancer: role in Rucaparib sensitivity.
Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
Epistasis in genomic and survival data of cancer patients.
Epstein-Barr Virus Infection and Altered Control of Apoptotic Pathways in Posttransplant Lymphoproliferative Disorders.
Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1.
ER maleate is a novel anticancer agent in oral cancer: Implications for cancer therapy.
ERCC1, PARP-1, and AQP1 as predictive biomarkers in colon cancer patients receiving adjuvant chemotherapy.
ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers.
Erratum for the Perspective: "Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action" by Y. Pommier, M. J. O'Connor, J. de Bono.
ERRATUM.
Erythropoietin-driven signalling and cell migration mediated by polyADP-ribosylation.
Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.
Establishment and Characterization of a Brca1-/-, p53-/- Mouse Mammary Tumor Cell Line.
Estradiol and progesterone regulate proliferation and apoptosis in colon cancer.
Estrogen enhances the cytotoxicity of PARP inhibitors on breast cancer cells through stimulating nitric oxide production.
Ethanol Extract of Securidaca longipedunculata Induces Apoptosis in Brain Tumor (U87) Cells.
Ethyl pyruvate administration inhibits hepatic tumor growth.
Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants.
Evaluation of a Low-Toxicity PARP Inhibitor as a Neuroprotective Agent for Parkinson's Disease.
Evaluation of absorption, distribution, metabolism, and excretion of [14C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors.
Evaluation of anti-tumorigenic activity of BP3B against colon cancer with patient-derived tumor xenograft model.
Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.
Evaluation of Drug-Drug Interactions of Rucaparib and CYP1A2, CYP2C9, CYP2C19, CYP3A, and P-gp Substrates in Patients With an Advanced Solid Tumor.
Evaluation of PARP and PDL-1 as potential therapeutic targets for women with high-grade neuroendocrine carcinomas of the cervix.
Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma.
Evaluation of tankyrase inhibition in whole cells.
Evaluation of the methods to identify patients who may benefit from PARP inhibitor use.
Evaluation of the pharmacodynamics and pharmacokinetics of the PARP inhibitor olaparib: a Phase I multicentre trial in patients scheduled for elective breast cancer surgery.
Evidence for tight coupling of Gi protein-mediated lysophosphatidic acid receptor to stimulated cytokine production in ovarian cancer cell.
Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis.
Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells.
Evolution of pre-existing versus acquired resistance to platinum drugs and PARP inhibitors in BRCA-associated cancers.
Evolutionary dynamics of cancer multidrug resistance in response to olaparib and photodynamic therapy.
EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.
Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response.
Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity.
Exceptional Response to Olaparib in a Patient With Recurrent Ovarian Cancer and an Entire BRCA1 Germline Gene Deletion.
Exogenous fatty acid binding protein 4 promotes human prostate cancer cell progression.
Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor.
Experiencia con el uso de olaparib en pacientes con cáncer de ovario.
Exploiting Defective DNA Repair in IDH-Mutant Cancers.
Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence.
Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer.
Exploring and comparing adverse events between PARP inhibitors.
Exploring the effect of PARP-1 flexibility in docking studies.
Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement.
Expression of DNA Damage Response Molecules PARP1, ?H2AX, BRCA1, and BRCA2 Predicts Poor Survival of Breast Carcinoma Patients.
Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations.
Expression of DNA damage response proteins in cervical cancer patients treated with radical chemoradiotherapy.
Expression of human poly (ADP-ribose) polymerase 1 in Saccharomyces cerevisiae: Effect on survival, homologous recombination and identification of genes involved in intracellular localization.
Expression of nuclear matrix proteins binding matrix attachment regions in prostate cancer. PARP-1: New player in tumor progression.
Expression of PARP-1 and its active polymer PAR in prostate cancer and benign prostatic hyperplasia in Chinese patients.
Expression of poly (adenosine diphosphate-ribose) polymerase and p53 in epithelial ovarian cancer and their role in prognosis and disease outcome.
Expression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model.
Expression of poly(ADP-ribose) polymerase in human hepatocellular carcinoma and analysis of biopsy specimens obtained under sonographic guidance.
Expression of potential biomarkers associated with homologous recombination repair in patients with ovarian or triple-negative breast cancer.
Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer.
Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells.
Extract of Solanum muricatum (Pepino/CSG) inhibits tumor growth by inducing apoptosis.
EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer.
F-Box Protein-Mediated Resistance to PARP Inhibitor Therapy.
Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro.
Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis.
FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells.
Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein.
FDA Approval Summary: Niraparib for the Maintenance Treatment of Patients with Recurrent Ovarian Cancer in Response to Platinum-Based Chemotherapy.
Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells.
First-line PARP inhibitors in ovarian cancer: summary of an ESMO Open - Cancer Horizons round-table discussion.
Flavanonol taxifolin attenuates proteasome inhibition-induced apoptosis in differentiated PC12 cells by suppressing cell death process.
Fluzoparib increases radiation sensitivity of non-small cell lung cancer (NSCLC) cells without BRCA1/2 mutation, a novel PARP1 inhibitor undergoing clinical trials.
Folic Acid Receptor-Mediated Targeting Enhances the Cytotoxicity, Efficacy, and Selectivity of Withania somnifera Leaf Extract: In vitro and in vivo Evidence.
Folliculin deficient renal cancer cells exhibit BRCA1 A complex expression impairment and sensitivity to PARP1 inhibitor olaparib.
FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function.
Fragile gene product, Fhit, in oxidative and replicative stress responses.
Free energy calculation provides insight into the action mechanism of selective PARP-1 inhibitor.
Frequency and prognostic value of mutations associated with the homologous recombination DNA repair pathway in a large pan cancer cohort.
Frequent occurrence of abnormal E-cadherin/beta-catenin protein expression in advanced gallbladder cancers and its association with decreased apoptosis.
From polypharmacology to target specificity: the case of PARP inhibitors.
Function and Regulation of the Mono-ADP-Ribosyltransferase ARTD10.
Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance.
Functional Characterization of Long Noncoding RNA Lnc_bc060912 in Human Lung Carcinoma Cells.
Functional Characterization of PALB2 Variants of Uncertain Significance: Toward Cancer Risk and Therapy Response Prediction.
Functional consequences of a rare missense BARD1 c.403G>A germline mutation identified in a triple-negative breast cancer patient.
Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects.
Functional Ex Vivo Assay to Select Homologous Recombination-Deficient Breast Tumors for PARP Inhibitor Treatment.
Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer.
Functional overexpression of human poly(ADP-ribose) polymerase in transfected rat tumor cells.
Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.
Further Analyses Highlight Benefits of PARP Inhibitors As Frontline Maintenance in Ovarian Cancer.
Fuzheng Qingjie Granules Inhibit Growth of Hepatoma Cells via Inducing Mitochondria-Mediated Apoptosis and Enhancing Immune Function.
Fuzuloparib: First Approval.
Gain-of-Function Mutant p53 R273H Interacts with Replicating DNA and PARP1 in Breast Cancer.
Galangin Inhibits Gastric Cancer Growth Through Enhancing STAT3 Mediated ROS Production.
Gamma ray-induced in vitro cell migration via EGFR/ERK/Akt/p38 activation is prevented by olaparib pretreatment.
Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery.
Garcinol Inhibits Cell Proliferation and Promotes Apoptosis in Pancreatic Adenocarcinoma Cells.
Gastrointestinal events with PARP inhibitors in cancer patients: A meta-analysis of phase II/III randomized controlled trials.
Gemcitabine impacts differentially on bladder and kidney cancer cells: distinct modulations in the expression patterns of apoptosis-related microRNAs and BCL2 family genes.
Gene Panel Tumor Testing in Ovarian Cancer Patients Significantly Increases the Yield of Clinically Actionable Germline Variants beyond BRCA1/BRCA2.
Generation of Dose-Response Curves and Improved IC50s for PARP Inhibitor Nanoformulations.
Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors.
Genetic Association of PARP15 Polymorphisms with Clinical Outcome of Acute Myeloid Leukemia in a Korean Population.
Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice.
Genetic diagnosis of familial breast cancer using clonal sequencing.
Genetic Dissection of PARylation in the Filamentous Fungus Neurospora crassa.
Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck.
Genetic sequence variations and ADPRT haplotype analysis in French Canadian families with high risk of breast cancer.
Genetics of triple-negative breast cancer: Implications for patient care.
Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest.
Genome-scale CRISPR knockout screen identifies TIGAR as a modifier of PARP inhibitor sensitivity.
Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer.
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.
Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2.
Genomic alterations and abnormal expression of APE2 in multiple cancers.
Genomic Characterization of High-Grade Serous Ovarian Cancer: Dissecting Its Molecular Heterogeneity as a Road Towards Effective Therapeutic Strategies.
Genomic Features of Metastatic Testicular Sex Cord Stromal Tumors.
Genomic hallmarks of homologous recombination deficiency in invasive breast carcinomas.
Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers.
Genomic instability in pancreatic adenocarcinoma: a new step towards precision medicine and novel therapeutic approaches.
Genomic landscape of metastatic breast cancer identifies preferentially dysregulated pathways and targets.
Genomic Profiling and Potentially Targetable Alterations in Pancreatic Ductal Adenocarcinoma.
Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.
Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers.
Genomic Testing in Patients with Metastatic Castration-resistant Prostate Cancer: A Pragmatic Guide for Clinicians.
Genomic, Transcriptomic, and Functional Alterations in DNA Damage Response Pathways as Putative Biomarkers of Chemotherapy Response in Ovarian Cancer.
Gentian violet induces wtp53 transactivation in cancer cells.
Geranylgeranyl transferase inhibition stimulates anti-melanoma immune response through MHC Class I and costimulatory molecule expression.
Germline Missense Variants in BRCA1: New Trends and Challenges for Clinical Annotation.
Germline mutations in Black patients with ovarian, fallopian tube and primary peritoneal carcinomas.
Germline mutations in RAD51D confer susceptibility to ovarian cancer.
Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.
Glioblastoma Cells Containing Mutations in the Cohesin Component STAG2 Are Sensitive to PARP Inhibition.
Glucuronorhamnoxylan from Capsosiphon fulvescens inhibits the growth of HT-29 human colon cancer cells in vitro and in vivo via induction of apoptotic cell death.
Glutathione-Depleting Pro-Oxidant as a Selective Anticancer Therapeutic Agent.
Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 gene.
Glycogen synthase kinase 3? inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer.
Gonadotropin-mediated chemoresistance: Delineation of molecular pathways and targets.
Gonadotropin-releasing hormone activates a rapid Ca2+-independent phosphodiester hydrolysis of polyphosphoinositides in pituitary gonadotrophs.
Gramine inhibits angiogenesis and induces apoptosis via modulation of TGF-? signalling in 7,12 dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinoma.
Granulocyte-macrophage colony stimulating factor activates proteoglycan, type II collagen, and cAMP production by rat articular chondrocytes through specific binding sites.
Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells.
Growth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells.
GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer.
Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways.
Gynaecological cancer: PARP inhibition - moving beyond BRCA-mutated disease.
Gynecologic Cancers: Emerging Novel Strategies for Targeting DNA Repair Deficiency.
H2AX a promising biomarker for lung cancer: a review.
Haematologic toxicities with PARP inhibitors in cancer patients: an up-to-date meta-analysis of 29 randomized controlled trials.
Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality.
Harnessing DNA Double-Strand Break Repair for Cancer Treatment.
HARP?111-136 enhances radiation-induced apoptosis of U87MG glioblastoma by induction of the proapoptotic protein CHOP.
Heat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties.
Heat shock protein inhibitors increase the efficacy of measles virotherapy.
Hedgehog/GLI1 Transcriptionally Regulates FANCD2 in Ovarian Tumor Cells: Its Inhibition Induces HR-Deficiency and Synergistic Lethality with PARP Inhibition.
HELB Is a Feedback Inhibitor of DNA End Resection.
Helicobacter pylori activation of PARP-1: Usurping a versatile regulator of host cellular health.
HER2 Overexpression Renders Human Breast Cancers Sensitive to PARP Inhibition Independently of Any Defect in Homologous Recombination DNA Repair.
Hereditary breast cancer: new genetic developments, new therapeutic avenues.
Hereditary breast cancer: pathobiology, clinical translation, and potential for targeted cancer therapeutics.
Hereditary Prostate Cancer: Genes Related, Target Therapy and Prevention.
Hexane fraction of adlay (Coix lachryma-jobi L.) testa ethanolic extract inhibits human uterine sarcoma cancer cells growth and chemosensitizes human uterine sarcoma cells to doxorubicin.
HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo.
High BRCA2 Gene Expression is Associated with Aggressive and Highly Proliferative Breast Cancer.
High energy shock waves and 5-aminolevulinic for sonodynamic therapy: effects in a syngeneic model of colon cancer.
High frequency of pathogenic germline variants within homologous recombination repair in patients with advanced cancer.
High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer.
High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma.
High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer.
High PARP-1 expression predicts poor survival in acute myeloid leukemia and PARP-1 inhibitor and SAHA-bendamustine hybrid inhibitor combination treatment synergistically enhances anti-tumor effects.
High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer.
High resolution melting profiles (HRMPs) obtained by magnetic induction cycler (MIC) have been used to monitor the BRCA2 status highlighted by next generation tumor sequencing (NGTS): a combined approach in a diagnostic environment.
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.
High specificity and efficiency electrochemical detection of poly(ADP-ribose) polymerase-1 activity based on versatile peptide-templated copper nanoparticles and detection array.
High-Throughput Colorimetric Assay for Identifying PARP-1 Inhibitors Using a Large Small-Molecule Collection.
Histone deacetylase inhibition of cardiac autophagy in rats on a high?fat diet with low?dose streptozotocin-induced type 2 diabetes mellitus.
Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells.
Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers.
Histone H2AX is a critical factor for cellular protection against DNA alkylating agents.
Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs.
Histone-dependent PARP-1 inhibitors: A novel therapeutic modality for the treatment of prostate and renal cancers.
HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells.
hMOB2 deficiency impairs homologous recombination-mediated DNA repair and sensitises cancer cells to PARP inhibitors.
Homologous recombination deficiency and ovarian cancer.
Homologous recombination in cancer development, treatment and development of drug resistance.
Homologous Recombination Repair Deficiency and Implications for Tumor Immunogenicity.
Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors.
Homologous Recombination-Mediated DNA Repair and Implications for Clinical Treatment of Repair Defective Cancers.
Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer.
Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells.
HORMAD1 is a negative prognostic indicator in lung adenocarcinoma and specifies resistance to oxidative and genotoxic stress.
Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections.
How and when to refer patients for oncogenetic counseling in the era of PARP inhibitors.
How to kill tumor cells with inhibitors of poly(ADP-ribosyl)ation.
HPMA copolymer-bound doxorubicin induces apoptosis in human ovarian carcinoma cells by a Fas-independent pathway.
HPW-RX40 restores anoikis sensitivity of human breast cancer cells by inhibiting integrin/FAK signaling.
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.
Human Mass Balance and Metabolite Profiling of [14 C]-Pamiparib, a Poly (ADP-Ribose) Polymerase Inhibitor, in Patients With Advanced Cancer.
Human MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2.
Human pancreatic tumor growth hormone (GH) - releasing factor and cyclic adenosine 3',5'- monophosphate evoke GH release from anterior pituitary cells: the effects of pertussis toxin, cholera toxin, forskolin, and cycloheximide.
Human V?2V?2 T cells limit breast cancer growth by modulating cell survival-, apoptosis-related molecules and microenvironment in tumors.
HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells.
Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.
Hyper-active non-homologous end joining selects for synthetic lethality resistant and pathological Fanconi anemia hematopoietic stem and progenitor cells.
Hypericin induced death receptor-mediated apoptosis in photoactivated tumor cells.
Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle.
Identification and Characterization of MortaparibPlus-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms.
Identification and mechanism of action analysis of the new PARP-1 inhibitor 2?-hydroxygenkwanol A.
Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1.
Identification and quantification of DNA repair protein poly(ADP ribose) polymerase 1 (PARP1) in human tissues and cultured cells by liquid chromatography/isotope-dilution tandem mass spectrometry.
Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).
Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer.
Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent.
Identification of a rearrangement in the 5' upstream region of the poly(ADP-ribose) polymerase pseudogene on chromosome 13 in Ewing's sarcoma cells.
Identification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors.
Identification of an antitumor effect of demethylzeylasteral on human gastric cancer cells.
Identification of biomarkers complementary to homologous recombination deficiency for improving the clinical outcome of ovarian serous cystadenocarcinoma.
Identification of BRCA1-like triple-negative breast cancers by quantitative multiplex-ligation-dependent probe amplification (MLPA) analysis of BRCA1-associated chromosomal regions: a validation study.
Identification of Novel Biomarkers of Homologous Recombination Defect in DNA Repair to Predict Sensitivity of Prostate Cancer Cells to PARP-Inhibitors.
Identification of Novel Interaction Partners of Ets-1: Focus on DNA Repair.
Identification of PARP-1 in cancer stem cells of gastrointestinal cancers: A preliminary study.
Identification of PARP-1, Histone H1 and SIRT-1 as New Regulators of Breast Cancer-Related Aromatase Promoter I.3/II.
Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.
Identification of poly(ADP-ribose) polymerase-1 as the OXPHOS-generated ATP sensor of nuclei of animal cells.
Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1).
Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay.
Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer.
Identifying and Overcoming Mechanisms of PARP Inhibitor Resistance in Homologous Recombination Repair-Deficient and Repair-Proficient High Grade Serous Ovarian Cancer Cells.
Identifying new piperazine-based PARP1 inhibitors using text mining and integrated molecular modeling approaches.
Identifying patients eligible for PARP inhibitor treatment: from NGS-based tests to 3D functional assays.
Ifosfamide-loaded poly (lactic-co-glycolic acid) PLGA-dextran polymeric nanoparticles to improve the antitumor efficacy in Osteosarcoma.
IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors.
IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage.
Imatinib modulates pro-inflammatory microenvironment with angiostatic effects in experimental lung carcinogenesis.
Immune Checkpoint and Poly(ADP-Ribose) Polymerase Inhibition for Recurrent Platinum-Resistant Ovarian and Metastatic Triple-Negative Breast Cancers.
Immune System and DNA Repair Defects in Ovarian Cancer: Implications for Locoregional Approaches.
Immunochemical analysis of poly(ADP-ribosyl)ation in HaCaT keratinocytes induced by the mono-alkylating agent 2-chloroethyl ethyl sulfide (CEES): Impact of experimental conditions.
Immunohistochemical detection of poly(ADP-ribose) polymerase inhibition by ABT-888 in patients with refractory solid tumors and lymphomas.
Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies.
Immunophenotypic predictive profiling of BRCA1-associated breast cancer.
Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown.
Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives.
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide.
Impact of mutations in homologous recombination repair genes on treatment outcomes for metastatic castration resistant prostate cancer.
Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme.
Impact of Polypharmacy for Chronic Ailments in Colon Cancer Patients: A Review Focused on Drug Repurposing.
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.
Impaired DNA damage response - An Achilles' heel sensitizing cancer to chemotherapy and radiotherapy.
Imprecise Medicine: BRCA2 Variants of Uncertain Significance (VUS), the Challenges and Benefits to Integrate a Functional Assay Workflow with Clinical Decision Rules.
Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm.
Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition.
Improved tumor-suppressive effect of OZ-001 combined with cisplatin mediated by mTOR/p70S6K and STAT3 inactivation in A549 human lung cancer cells.
In silico discovery of novel flavonoids as poly ADP ribose polymerase (PARP) inhibitors.
In Silico Investigation of Potential PARP-1 Inhibitors from Traditional Chinese Medicine.
In Silico Screening Identifies a Novel Potential PARP1 Inhibitor Targeting Synthetic Lethality in Cancer Treatment.
In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016.
In vitro effects of poly(ADP-ribose) polymerase inhibitors on the production of tumor necrosis factor-? by interferon- ? - and lipopolysaccharide-stimulated peripheral blood mononuclear cells of horses.
In Vitro Long-Term Proliferation Assays to Study Antiproliferative Effects of PARP Inhibitors on Cancer Cells.
In vivo and in vitro antitumor effects of platycodin d, a saponin purified from platycodi radix on the h520 lung cancer cell.
In vivo imaging of specific drug-target binding at subcellular resolution.
In Vivo therapeutic potential of mesenchymal stem cell-derived extracellular vesicles with optical imaging reporter in tumor mice model.
In vivo visualization of PARP inhibitor pharmacodynamics.
Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance tosorafenib in hepatocellular carcinoma cells.
Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells.
Inactivation of the prolyl isomerase Pin1 sensitizes BRCA1-proficient breast cancer to PARP inhibition.
Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP.
Increased cell-surface receptor expression on U-937 cells induced by 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine.
Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints.
Increased Occurrence of Caspase-Dependent Apoptosis in Unfavorable Neuroblastomas.
Increased PARP Activity and DNA Damage in NSCLC Patients: The Influence of COPD.
Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity.
Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis.
Indicators of homologous recombination deficiency in breast cancer and association with response to neoadjuvant chemotherapy.
Individual and Combined Expression of DNA Damage Response Molecules PARP1, ?H2AX, BRCA1, and BRCA2 Predict Shorter Survival of Soft Tissue Sarcoma Patients.
Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-??, blocking angiogenesis and regulation of mitochondrial apoptotic pathway.
Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin.
Inducing Synthetic Lethality using PARP Inhibitors.
Induction of adenosine A1 receptor expression by pertussis toxin via an adenosine 5'-diphosphate ribosylation-independent pathway.
Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol.
Induction of Apoptosis and Reduction of Endogenous Glutathione Level by the Ethyl-Acetate Soluble Fraction of the Methanol Extract of the Roots of Potentilla fulgens in Cancer Cells.
Induction of Bax protein and degradation of lamin A during p53-dependent apoptosis induced by chemotherapeutic agents in human cancer cell lines.
Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy.
Induction of CD4(+) and CD8(+) Bordetella pertussis toxin subunit S1 specific T cells by immunization with synthetic peptides.
Induction of endonuclease-mediated apoptosis in tumor cells by C-nitroso-substituted ligands of poly(ADP-ribose) polymerase.
Induction of necrosis in human liver tumor cells by ?-phellandrene.
Induction of non-small cell lung carcinoma apoptosis using soluble RGD-TRAIL by targeting the integrin receptor of tumor cells.
Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines.
Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan.
Inherited gynaecological cancers.
Inherited variation in the PARP1 gene and survival from melanoma.
Inhibited effects of veliparib combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line.
Inhibiteurs de la PARP : des avancées significatives dans le traitement des cancers.
Inhibiting Mitochondrial DNA Ligase III? Activates Caspase 1-Dependent Apoptosis in Cancer Cells.
Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression.
Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib.
Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo.
Inhibition of c-MET increases the antitumour activity of PARP inhibitors in gastric cancer models.
Inhibition of cell growth and potentiation of tumor necrosis factor-? (TNF-?)-induced apoptosis by a phenanthroindolizidine alkaloid antofine in human colon cancer cells.
Inhibition of gastric tumor growth by a novel Hsp90 inhibitor.
Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds.
Inhibition of MEK suppresses hepatocellular carcinoma growth through independent MYC and BIM regulation.
Inhibition of methylazoxymethanol acetate initiation of colon carcinogenesis in rats by treatment with the poly(ADP-ribose)polymerase inhibitor 3-aminobenzamide.
Inhibition of neuroblastoma xenograft growth by Hsp90 inhibitors.
Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line.
Inhibition of Parp1 by BMN673 Effectively Sensitizes Cells to Radiotherapy by Upsetting the Balance of Repair Pathways Processing DNA Double-Strand Breaks.
Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin.
Inhibition of Pim-2 kinase by LT-171-861 promotes DNA damage and exhibits enhanced lethal effects with PARP inhibitor in multiple myeloma.
Inhibition of poly (ADP-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells.
Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability.
Inhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression.
Inhibition of poly(ADP-RIBOSE) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species.
Inhibition of poly(ADP-ribose) polymerase (PARP) induces apoptosis in lung cancer cell lines.
Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene.
Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis.
Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.
Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models.
Inhibition of Poly(ADP-Ribose) Polymerase Enhances Radiochemosensitivity in Cancers Proficient in DNA Double-Strand Break Repair.
Inhibition of Poly(ADP-Ribose) Polymerase Enhances the Effect of Chemotherapy in an Animal Model of Regional Therapy for the Treatment of Advanced Extremity Malignant Melanoma.
Inhibition of poly(ADP-ribose) polymerase in cancer.
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis.
Inhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs.
Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma.
Inhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.
Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.
Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP?ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells.
Inhibition of poly(ADP-ribosyl)ation in cancer: old and new paradigms revisited.
Inhibition of Stat3 Activity by YC-1 Enhances Chemo-Sensitivity in Hepatocellular Carcinoma.
Inhibition of T cell homing by down-regulation of CD62L and the induction of a Th-2 response as a method to prevent acute allograft rejection in mice.
Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.
Inhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis.
Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer.
Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling.
Inhibitor of apoptosis protein Livin promotes tumor progression and chemoradioresistance in human anaplastic thyroid cancer.
Inhibitory Effects of Different Forms of Tocopherols, Tocopherol Phosphates, and Tocopherol Quinones on Growth of Colon Cancer Cells.
Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison.
Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a Bona Fide PARP inhibitor.
Iniparib, a PARP1 inhibitor for the potential treatment of cancer, including triple-negative breast cancer.
Innovative Strategies: Targeting Subtypes in Metastatic Breast Cancer.
INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin.
Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells.
INPP4B overexpression enhances the antitumor efficacy of PARP inhibitor AG014699 in MDA-MB-231 triple-negative breast cancer cells.
Insights into PARP Inhibitors' Selectivity Using Fluorescence Polarization and Surface Plasmon Resonance Binding Assays.
Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
Insulin regulates cleavage of procaspase-9 via binding of X chromosome-linked inhibitor of apoptosis protein in HT-29 cells.
Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo.
Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines.
Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma.
Integrated support vector machine and pharmacophore based virtual screening driven identification of thiophene carboxamide scaffold containing compound as potential PARP1 inhibitor.
Integrating PARP Inhibitors Into Advanced Prostate Cancer Therapeutics.
Integrating PARP inhibitors into the management of breast cancer: where are we?
Integrin-independent support of cancer drug resistance by tetraspanin CD151.
Interaction between N-cadherin and decoy receptor-2 regulates apoptosis in head and neck cancer.
Interaction of BARD1 and HP1 is required for BRCA1 retention at sites of DNA damage.
Interaction of germline variants in a family with a history of early-onset clear cell renal cell carcinoma.
Interactive effects of pertussis toxin and the phorbol ester tumour promotor, phorbol dibutyrate, on T-lymphocyte mitogenesis and the expression of phenotypic determinants.
Interfaces between cellular responses to DNA damage and cancer immunotherapy.
Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: role of interleukin 1beta.
Intracellular elevations of free calcium induced by activation of histamine H1 receptors in interphase and mitotic HeLa cells: hormone signal transduction is altered during mitosis.
Intracellular trafficking and surface expression of SS-A (Ro), SS-B (La), poly(ADP-ribose) polymerase and alpha-fodrin autoantigens during apoptosis in human salivary gland cells induced by tumour necrosis factor-alpha.
Intratumor administration of interleukin 13 receptor-targeted cytotoxin induces apoptotic cell death in human malignant glioma tumor xenografts.
Intravesical therapy with pertussis toxin before radical cystectomy in patients with bladder cancer: a Phase I study.
Investigating isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins for ovarian cancer treatment.
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy.
Investigating the Mechanistic Inhibitory Discrepancies of Novel Halogen and Alkyl Di-Substituted Oxadiazole-Based Dibenzo-Azepine-Dione Derivatives on Poly (ADP-Ribose) Polymerase-1.
Investigation of U-251 cell death triggered by flavonoid luteolin: towards a better understanding on its anticancer property against glioblastomas.
Investigational CHK1 inhibitors in early phase clinical trials for the treatment of cancer.
Investigational PARP inhibitors for the treatment of biliary tract cancer: spotlight on preclinical and clinical studies.
Involvement of homologous recombination in the synergism between cisplatin and poly(ADP-ribose) polymerase inhibition.
Involvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis.
Iodinated benzimidazole PARP radiotracer for evaluating PARP1/2 expression in vitro and in vivo.
Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells.
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Is there an epigenetic component underlying the resistance of triple-negative breast cancers to parp inhibitors?
Isolation of 4,4'-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma.
Isolation, Characterization and Anticancer Potential of Cytotoxic Triterpenes from Betula utilis Bark.
ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells.
JF-305, a pancreatic cancer cell line is highly sensitive to the PARP inhibitor olaparib.
Kaempferol Protects Against Hydrogen Peroxide-Induced Retinal Pigment Epithelium Cell Inflammation and Apoptosis by Activation of SIRT1 and Inhibition of PARP1.
Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent.
KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation.
KIFC1 is a novel potential therapeutic target for breast cancer.
Kinetic and static analysis of poly-(adenosine diphosphate-ribose) polymerase-1 (PARP-1) targeted 18F-FluorThanatrace (18F-FTT) PET images of ovarian cancer.
KML001, a telomere-targeting drug, sensitizes glioblastoma cells to temozolomide chemotherapy and radiotherapy through DNA damage and apoptosis.
Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers.
Labeling Substrate Proteins of Poly(ADP-ribose) Polymerases with Clickable NAD Analog.
Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment.
Landmark trials in the medical oncology management of metastatic breast cancer.
Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action.
Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.
Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors.
Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway.
Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells.
Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine.
LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors.
LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL.
LncRNA-SLC6A9-5:2: A potent sensitizer in 131I-resistant papillary thyroid carcinoma with PARP-1 induction.
LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma.
Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts.
Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR.
Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors.
Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1.
Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy.
Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity.
Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness.
Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors.
Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.
Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells.
Loss of heterozygosity as a marker of homologous repair deficiency in multiple myeloma: a role for PARP inhibition?
Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.
Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy.
Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells.
Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors.
Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice.
Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition.
Loss of the p12 subunit of DNA polymerase delta leads to a defect in HR and sensitization to PARP inhibitors.
Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma.
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.
Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases.
Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo.
Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis by increasing M1-type macrophages and activating the Bax/Bcl-2/caspase-3/PARP pathway.
LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.
LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair.
Lupus susceptibility genes on human chromosome 1.
Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2.
Lysophosphatidic acid induces focal adhesion assembly through Rho/Rho-associated kinase pathway in human ovarian cancer cells.
M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide.
m5C modification of mRNA serves a DNA damage code to promote homologous recombination.
MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.
Magnitude of benefit of the addition of poly ADP-ribose polymerase (PARP) inhibitors to therapy for malignant tumor: A meta-analysis.
Major clinical research advances in gynecologic cancer in 2018.
Management of early breast cancer in patients bearing germline BRCA mutations.
MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer.
Matrix screen identifies synergistic combination of PARP inhibitors and nicotinamide phosphoribosyltransferase (NAMPT) inhibitors in Ewing sarcoma.
MCM4 Is a Novel Biomarker Associated With Genomic Instability, BRCAness Phenotype, and Therapeutic Potentials in Soft-Tissue Sarcoma.
mda-7/IL-24 induces apoptosis in human GBC-SD gallbladder carcinoma cells via mitochondrial apoptotic pathway.
MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF.
Mechanism and current progress of Poly ADP-ribose polymerase (PARP) inhibitors in the treatment of ovarian cancer.
Mechanism of Action and Clinical Efficacy of CDK4/6 Inhibitors in BRCA-Mutated, Estrogen Receptor-Positive Breast Cancers: Case Report and Literature Review.
Mechanisms of acquired resistance of BRCA1/2-driven tumors to platinum compounds and PARP inhibitors.
Mechanisms of naringenin-induced apoptotic cascade in cancer cells: involvement of estrogen receptor alpha and beta signalling.
Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response.
Mechanisms of PARP inhibitor resistance in ovarian cancer.
Mechanisms of PARP inhibitor sensitivity and resistance.
Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer.
Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors.
Mediation of cell death by poly(ADP-ribose) polymerase-1.
Medical Management of newly diagnosed breast cancer in a BRCA1/2 mutation carrier.
Medicinal chemistry approaches of poly ADP-Ribose polymerase 1 (PARP1) inhibitors as anticancer agents - A recent update.
MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors.
Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ?.
Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events.
Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-?B Signaling.
Metabolic roles of poly(ADP-ribose) polymerases.
Metastatic Castration-Resistant Prostate Cancer with Neuroendocrine Transformation and BRCA 1 Germ-Line Mutation: A Case Report and Literature Review.
Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib.
Metformin reverses PARP inhibitors-induced epithelial-mesenchymal transition and PD-L1 upregulation in triple-negative breast cancer.
METH-Induced Neurotoxicity Is Alleviated by Lactulose Pretreatment Through Suppressing Oxidative Stress and Neuroinflammation in Rat Striatum.
Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features.
Methylation of tumor suppressor genes is related with copy number aberrations in breast cancer.
MGMT Expression Predicts PARP-Mediated Resistance to Temozolomide.
MicroRNA216b mediated downregulation of HSP27/STAT3/AKT signaling is critically involved in lambertianic acid induced apoptosis in human cervical cancers.
MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers.
Microsatellite instability induced mutations in DNA repair genes Ctip and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors in myeloidmalignancies.
Midkine silencing enhances the anti-prostate cancer stem cell activity of the flavone apigenin: cooperation on signaling pathways regulated by ERK, p38, PTEN, PARP, and NF-?B.
MIF is a 3' flap nuclease that facilitates DNA replication and promotes tumor growth.
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.
Minor grove binding ligands disrupt PARP-1 activation pathways.
MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.
miR-151-5p, targeting chromatin remodeler SMARCA5, as a marker for the BRCAness phenotype.
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors.
miR-223 reverses experimental pulmonary arterial hypertension.
miR-7-5p overexpression suppresses cell proliferation and promotes apoptosis through inhibiting the ability of DNA damage repair of PARP-1 and BRCA1 in TK6 cells exposed to hydroquinone.
MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review.
MiRNA-200C expression in Fanconi anemia pathway functionally deficient lung cancers.
Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase.
Mitigating effect of biotin against irradiation-induced cerebral cortical and hippocampal damage in the rat brain tissue.
Mitochondria and chronic effects of cancer therapeutics: The clinical implications.
Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity.
Mitochondrial DNA depletion sensitizes cancer cells to PARP inhibitors by translational and post-translational repression of BRCA2.
Mitochondrial dysfunction in cancer chemoresistance.
Mitochondrial Protection by PARP Inhibition.
MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation.
MLN4924 suppresses the BRCA1 complex and synergizes with PARP inhibition in NSCLC cells.
MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells.
Modeling of the Enzyme-Substrate Complexes of Human Poly(ADP-Ribose) Polymerase 1.
Modeling pharmacodynamic response to the poly(ADP-Ribose) polymerase inhibitor ABT-888 in human peripheral blood mononuclear cells.
Modeling Therapy Resistance in BRCA1/2-Mutant Cancers.
Modulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress.
Modulation of brain tumor risk by genetic SNPs in PARP1gene: Hospital based case control study.
Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x.
Modulation of the antiproliferative activity of anticancer drugs in hematopoietic tumor cell lines by the poly(ADP-ribose) polymerase inhibitor 6(5H)-phenanthridinone.
Modulation of the cancer susceptibility measure, adenosine diphosphate ribosyl transferase (ADPRT), by differences in low-dose n-3 and n-6 fatty acids.
Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53.
Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation.
Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity.
Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy.
Molecular mechanisms of cholangiocarcinoma cell inhibition by medicinal plants.
Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progression.
Molecular Modeling Studies on Benzimidazole Carboxamide Derivatives as PARP-1 Inhibitors Using 3D-QSAR and Docking.
Molecular natural history of breast cancer: Leveraging transcriptomics to predict breast cancer progression and aggressiveness.
Molecular pathways: exploiting tumor-specific molecular defects in DNA repair pathways for precision cancer therapy.
Molecular pathways: how can BRCA-mutated tumors become resistant to PARP inhibitors?
Molecular Pathways: Targeting DNA Repair Pathway Defects Enriched in Metastasis.
Molecular Pathways: Targeting ETS Gene Fusions in Cancer.
Molecular Pathways: Targeting PARP in Cancer Treatment.
Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement.
Molecular stratification of triple-negative breast cancers.
Molecular Testing Identifies Determinants of Exceptional Response and Guides Precision Therapy in a Patient with Lethal, Treatment-emergent Neuroendocrine Prostate Cancer.
Molecular Testing in Breast Cancer.
Molecular-targeted therapy toward precision medicine for gastrointestinal caner: Current progress and challenges.
Monitoring and signaling of radiation-induced damage in mammalian cells.
Morin Hydrate Reverses Cisplatin Resistance by Impairing PARP1/HMGB1-Dependent Autophagy in Hepatocellular Carcinoma.
Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells.
Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers.
Mouse models for BRCA1 associated tumorigenesis: from fundamental insights to preclinical utility.
Movement of Poly-ADP Ribose (PARP) Inhibition into Frontline Treatment of Ovarian Cancer.
Moving beyond PARP Inhibition in ATM-Deficient Prostate Cancer.
Moving beyond PARP Inhibition: Current State and Future Perspectives in Breast Cancer.
Moving From Mutation to Actionability.
Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy.
Moving toward personalized medicine: treatment-focused genetic testing of women newly diagnosed with ovarian cancer.
Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1.
MTA2 sensitizes gastric cancer cells to PARP inhibition by induction of DNA replication stress.
mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer.
mTOR, S6 and AKT expression in relation to proliferation and apoptosis/autophagy in glioma.
Multi gene panel testing for hereditary breast cancer - is it ready to be used?
Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases.
Multifarious molecular signaling cascades of cardiac hypertrophy: can the muddy waters be cleared?
Mutant p53L194F Harboring Luminal-A Breast Cancer Cells Are Refractory to Apoptosis and Cell Cycle Arrest in Response to MortaparibPlus, a Multimodal Small Molecule Inhibitor.
Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer.
Mutational Profile of Aggressive, Localised Prostate Cancer from African Caribbean Men Versus European Ancestry Men.
Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy.
MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death.
MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer.
Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.
MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma.
Myelodysplastic syndrome and acute myeloid leukaemia in patients treated with PARP inhibitors: a safety meta-analysis of randomised controlled trials and a retrospective study of the WHO pharmacovigilance database.
Myocardial cell death and regeneration during progression of cardiac hypertrophy to heart failure.
NAD+ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition.
NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression.
NAD[S], an NAD analogue with reduced susceptibility to phosphodiesterase. Chemical synthesis and enzymic properties.
Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation.
Nanoformulation of Talazoparib Delays Tumor Progression and Ascites Formation in a Late Stage Cancer Model.
Nanomedicine-based paclitaxel induced apoptotic signaling pathways in A562 leukemia cancer cells.
Nanoparticle Formulations of Poly (ADP-ribose) Polymerase Inhibitors for Cancer Therapy.
Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.
Natural and glucosyl flavonoids inhibit poly(ADP-ribose) polymerase activity and induce synthetic lethality in BRCA mutant cells.
Natural product ?-thujaplicin inhibits homologous recombination repair and sensitizes cancer cells to radiation therapy.
NEAT1 Knockdown Suppresses the Cisplatin Resistance in Ovarian Cancer by Regulating miR-770-5p/PARP1 Axis.
Neoadjuvant degarelix with or without apalutamide followed by radical prostatectomy for intermediate and high-risk prostate cancer: ARNEO, a randomized, double blind, placebo-controlled trial.
Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model.
Neuroglobin, a pro-survival player in estrogen receptor ?-positive cancer cells.
New (E)-1-alkyl-1H-benzo[d]imidazol-2-yl)methylene)indolin-2-ones: Synthesis, in vitro cytotoxicity evaluation and apoptosis inducing studies.
New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules.
New chalcone derivative exhibits antiproliferative potential by inducing G2/M cell cycle arrest, mitochondrial-mediated apoptosis and modulation of MAPK signalling pathway.
New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment.
New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy.
New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy.
New PARP targets for cancer therapy.
New Perspectives for Resistance to PARP Inhibitors in Triple-Negative Breast Cancer.
New Targeted Agents in Gynecologic Cancers: Synthetic Lethality, Homologous Recombination Deficiency, and PARP Inhibitors.
New Therapeutic and Biomarker Discovery for Peripheral Diabetic Neuropathy: PARP Inhibitor, Nitrotyrosine, and Tumor Necrosis Factor-{alpha}
New therapeutic perspectives in CCDC6 deficient lung cancer cells.
New Therapeutic Strategies for Triple-Negative Breast Cancer.
Next-generation sequencing-based BRCA testing on cytological specimens from ovarian cancer ascites reveals high concordance with tumour tissue analysis.
NF-?B mediates radio-sensitization by the PARP-1 inhibitor, AG-014699.
NF-kB signaling mediates acquired resistance after PARP inhibition.
NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma.
NF?B and Poly (ADP-ribose) Polymerase 1 Form a Positive Feedback Loop that Regulates DNA Repair in Acute Myeloid Leukemia Cells.
NF?B Down-regulation and PARP Cleavage by Novel 3-?-Butyryloxy-?-boswellic Acid Results in Cancer Cell Specific Apoptosis and in vivo Tumor Regression.
Nickel(II) affects poly(ADP-ribose) polymerase-mediated DNA repair in normal and cancer cells.
Nicotinamide abrogates acute lung injury caused by ischaemia/reperfusion.
Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer.
Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells.
Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models.
Niraparib as Maintenance Therapy in Germline ATM-mutated and Somatic BRCA2-mutated Ovarian Cancer with Brain Metastases: A Case Report and Literature Review.
Niraparib for the Treatment of Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.
Niraparib Suppresses Cholangiocarcinoma Tumor Growth by Inducing Oxidative and Replication Stress.
Niraparib: A Poly(ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination.
Niraparib: A Review in Ovarian Cancer.
Niraparib: First Global Approval.
Nitric oxide induced poly(ADP-ribose) polymerase cleavage in RAW 264.7 macrophage apoptosis is blocked by Bcl-2.
Nitric oxide-donor/PARP-inhibitor combination: A new approach for sensitization to ionizing radiation.
Nitric Oxide: Genomic Instability And Synthetic Lethality.
No associations of polymorphisms in ADPRT with hepatitis B virus clearance and hepatocellular carcinoma occurrence in a Korean population.
No evidence for PALB2 methylation in high-grade serous ovarian cancer.
Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-?B Signaling after Nuclear DNA Damage.
Non-NAD-Like poly(ADP-Ribose) Polymerase-1 Inhibitors effectively Eliminate Cancer in vivo.
Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors.
Non-thermal plasma-induced apoptosis is modulated by ATR- and PARP1-mediated DNA damage responses and circadian clock.
Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression.
Novel ?-Carboline/Hydroxamic Acid Hybrids Targeting Both Histone Deacetylase and DNA Display High Anticancer Activity via Regulation of the p53 Signaling Pathway.
Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia.
Novel Azaquinolones as PARP1 Inhibitors for Treating Cancer.
Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas.
Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells.
Novel Compound 1, 3-bis (3, 5-dichlorophenyl) urea Inhibits Lung Cancer Progression.
Novel DNA targeted therapies for head and neck cancers: clinical potential and biomarkers.
Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis.
Novel insights into PARPs in gene expression: regulation of RNA metabolism.
Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution.
Novel poly (ADP-ribose) polymerase inhibitor, AZD2281, enhances radiosensitivity of both normoxic and hypoxic esophageal squamous cancer cells.
Novel Poly(ADP-ribose) Polymerase-1 Inhibitor DDHCB Inhibits Proliferation of BRCA Mutant Breast Cancer Cell In Vitro and In Vivo through a Synthetic Lethal Mechanism.
Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.
Novel poly-ADP-ribose polymerase inhibitor combination strategies in ovarian cancer.
Novel roles of 1?,25(OH)2D3 on DNA repair provide new strategies for breast cancer treatment.
Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action.
Novel Therapeutics for Ovarian Cancer: The 11th Biennial Rivkin Center Ovarian Cancer Research Symposium.
Novel treatment strategies in triple-negative breast cancer: specific role of poly(adenosine diphosphate-ribose) polymerase inhibition.
Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.
NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers.
NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells.
Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells.
Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer.
Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line.
NVP-LDE-225 (Erismodegib) inhibits epithelial-mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2R? null mice by regulating Bmi-1 and microRNA-128.
Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells.
Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L.
Olaparib , PARP1 inhibitor in ovarian cancer.
Olaparib and temozolomide in desmoplastic small round cell tumors: a promising combination in vitro and in vivo.
Olaparib as maintenance treatment for patients with platinum-sensitive relapsed ovarian cancer.
Olaparib effective in four advanced cancers.
Olaparib for metastatic breast cancer in a patient with a germline PALB2 variant.
Olaparib for the treatment of ovarian cancer.
Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy.
Olaparib in germline-mutated metastatic breast cancer: implications of the OlympiAD trial.
Olaparib in the management of ovarian cancer.
Olaparib increases the therapeutic index of hemithoracic irradiation compared with hemithoracic irradiation alone in a mouse lung cancer model.
Olaparib Inhibits Tumor Growth of Hepatoblastoma in Patient-Derived Xenograft Models.
Olaparib Keeps Hereditary Breast Tumors in Check.
Olaparib modulates DNA repair efficiency, sensitizes cervical cancer cells to cisplatin and exhibits anti-metastatic property.
Olaparib shows promise in multiple tumor types.
Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration.
Olaparib Synergizes the Anticancer Activity of Daunorubicin via Interaction with AKR1C3.
Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours.
Olaparib Tablet: A Review in Ovarian Cancer Maintenance Therapy.
Olaparib Targets Some Advanced Prostate Cancers.
Olaparib-Based Photoaffinity Probes for PARP-1 Detection in Living Cells.
Olaparib: A tale of two dosage forms.
Olaparib: an oral PARP-1 and PARP-2 inhibitor with promising activity in ovarian cancer.
Olaparib: first global approval.
Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence.
Oleanolic Acid Induces Apoptosis in Human Leukemia Cells through Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage.
Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer.
ONS-donor ligand based Pt(II) complexes display extremely high anticancer potency through autophagic cell death pathway.
Opening a Door to PARP Inhibitor-Induced Lethality in HR-Proficient Human Tumor Cells.
Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity.
Optimizing PARP inhibition through combined epigenetic and immunotherapy.
Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice.
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial.
Oral treatment of the TRAMP mice with doxazosin suppresses prostate tumor growth and metastasis.
OSU-A9 induced-reactive oxygen species cause cytotoxicity in duodenal and gastric cancer cells by decreasing phosphorylated nuclear pyruvate kinase M2 protein levels.
Ovarian cancer cells, not normal cells, are damaged by Mirk/Dyrk1B kinase inhibition.
Ovarian cancer stem cells: ready for prime time?
Ovarian Cancer Translational Activity of the Multicenter Italian Trial in Ovarian Cancer (MITO) Group: Lessons Learned in 10 Years of Experience.
Ovarian cancer treatment in mutation carriers/brcaness.
Ovarian cancer.
Overcoming PARPi resistance: Preclinical and clinical evidence in ovarian cancer.
Overcoming Platinum and PARP-Inhibitor Resistance in Ovarian Cancer.
Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations.
Overcoming Resistance of Glioblastoma to Conventional Cytotoxic Therapies by the Addition of PARP Inhibitors.
Overcoming Treatment Toxicity through Sequential Therapy.
Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: evidence for increased tumor cell apoptosis in vivo.
Overexpression of IRS-4 Correlates with Procaspase 3 Levels in Tumoural Tissue of Patients with Colorectal Cancer.
Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB.
Overexpression of PARP is an independent prognostic marker for poor survival in Middle Eastern breast cancer and its inhibition can be enhanced with embelin co-treatment.
Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis.
Oxidative stress, DNA repair, and cancer susceptibility.
p53 Activation by nitric oxide involves down-regulation of Mdm2.
p53 Enhances Artemisia annua L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells.
p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity.
p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors.
Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway.
PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1.
Pamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-escalation stage of a multicentre, open-label, phase 1a/b trial.
Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumor.
Pamiparib: First Approval.
Pan-Cancer Analysis of BRCA1 and BRCA2 Genomic Alterations and Their Association With Genomic Instability as Measured by Genome-Wide Loss of Heterozygosity.
Pan-cancer analysis of genomic scar signatures associated with homologous recombination deficiency suggests novel indications for existing cancer drugs.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells.
Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib.
Papers of note in Science Translational Medicine 9 (392).
Parasporin-2 from a New Bacillus thuringiensis 4R2 Strain Induces Caspases Activation and Apoptosis in Human Cancer Cells.
Parent-Metabolite Pharmacokinetic Modeling and Pharmacodynamics of Veliparib (ABT-888), a PARP Inhibitor, in Patients With BRCA 1/2-Mutated Cancer or PARP-Sensitive Tumor Types.
PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency.
PARG inhibitors and functional PARG inhibition models.
PARG Inhibitors and Functional PARG Inhibition Models.
PARG regulates the proliferation and differentiation of DCs and T cells via PARP/NF??B in tumour metastases of colon carcinoma.
PARP (Poly ADP-Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer.
PARP activity and inhibition in fetal and adult oligodendrocyte precursor cells: Effect on cell survival and differentiation.
PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues - A population pharmacokinetic/pharmacodynamic analysis of rucaparib.
PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells.
PARP and other prospective targets for poisoning cancer cell metabolism.
PARP and PARG inhibitors in cancer treatment.
PARP and PARG Inhibitors-New Therapeutic Targets in Cancer Treatment.
PARP and PD-1/PD-L1 checkpoint inhibition in recurrent or metastatic endometrial cancer.
PARP cleavage and perturbance in mitochondrial membrane potential by 3-?-propionyloxy-?-boswellic acid results in cancer cell death and tumor regression in murine models.
PARP expression in germ cell tumours.
PARP inhibition and gynecologic malignancies: A review of current literature and on-going trials.
PARP inhibition and immune modulation: scientific rationale and perspectives for the treatment of gynecologic cancers.
PARP inhibition and the radiosensitizing effects of the PARP inhibitor ABT-888 in in vitro hepatocellular carcinoma models.
PARP Inhibition as a Prototype for Synthetic Lethal Screens.
PARP inhibition as frontline therapy in ovarian cancer.
PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.
PARP inhibition causes premature loss of cohesion in cancer cells.
PARP Inhibition Combined With Thoracic Irradiation Exacerbates Esophageal and Skin Toxicity in C57BL6 Mice.
PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer.
PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer.
PARP Inhibition in Cancer: An Update on Clinical Development.
PARP inhibition in epithelial ovarian cancer: high hopes undergo a reality check.
PARP inhibition in the ovarian cancer patient: Current approvals and future directions.
PARP inhibition in UV-associated angiosarcoma preclinical models.
PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality-An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness.
PARP Inhibition Increases the Response to Chemotherapy in Uveal Melanoma.
PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer.
PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells.
PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.
PARP inhibition protects mitochondria and reduces ROS production via PARP-1-ATF4-MKP-1-MAPK retrograde pathway.
PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells.
PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.
PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis.
PARP inhibition sensitizes to low dose-rate radiation TMPRSS2-ERG fusion gene-expressing and PTEN-deficient prostate cancer cells.
PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2.
PARP inhibition: A promising therapeutic target in ovarian cancer.
PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers.
PARP inhibitor (PARPi) monotherapy treatment in non-BRCA and/or non-serous gynaecological cancers.
PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression.
PARP inhibitor and chemotherapy combination trials for the treatment of advanced malignancies: does a development pathway forward exist?
PARP inhibitor associated treatment related myeloid neoplasms: What was a "Rare" complication may be less so.
PARP inhibitor attenuated colony formation can be restored by MAP kinase inhibitors in different irradiated cancer cell lines.
PARP inhibitor combination therapy.
PARP inhibitor development for systemic cancer targeting.
PARP Inhibitor Drugs In The Treatment Of Breast, Ovarian, Prostate And Pancreatic Cancers: An Update of Clinical Trials.
PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer.
PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer.
PARP inhibitor olaparib increases the oncolytic activity of dl922-947 in in vitro and in vivo model of anaplastic thyroid carcinoma.
PARP inhibitor olaparib sensitizes cholangiocarcinoma cells to radiation.
PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells.
PARP Inhibitor PJ34 Suppresses Osteogenic Differentiation in Mouse Mesenchymal Stem Cells by Modulating BMP-2 Signaling Pathway.
PARP inhibitor resistance and TP53 mutations in patients treated with olaparib for BRCA-mutated cancer: Four case reports.
PARP Inhibitor Resistance Mechanisms and Implications for Post-Progression Combination Therapies.
PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells.
PARP inhibitor resistance: the underlying mechanisms and clinical implications.
PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS.
PARP inhibitor tilts cell death from necrosis to apoptosis in cancer cells.
PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression.
PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines.
PARP inhibitors and cancer therapy - early results and potential applications.
PARP inhibitors and immunotherapy in ovarian and endometrial cancers.
PARP inhibitors and more.
PARP inhibitors and newly second primary malignancies in cancer patients: a systematic review and safety meta-analysis of placebo randomized controlled trials.
PARP Inhibitors and Prostate Cancer: To Infinity and Beyond BRCA.
PARP inhibitors and radiation potentiate liver cell death in vitro. Do hepatocellular carcinomas have an achilles' heel?
PARP Inhibitors and the Evolving Landscape of Ovarian Cancer Management: A Review.
PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2?
PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers.
PARP inhibitors as antitumor agents: a patent update (2013-2015).
PARP inhibitors as potential therapeutic agents for various cancers: focus on niraparib and its first global approval for maintenance therapy of gynecologic cancers.
PARP Inhibitors as Therapeutics: Beyond Modulation of PARylation.
PARP inhibitors blaze a trail in difficult-to-treat cancers.
PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts.
PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma.
PARP inhibitors for BRCA wild type ovarian cancer; gene alterations, homologous recombination deficiency and combination therapy.
PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies.
PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions.
PARP inhibitors for cancer therapy.
PARP Inhibitors for Cancer Therapy.
PARP Inhibitors for Ovarian Cancer: Current Indications, Future Combinations, and Novel Assets in Development to Target DNA Damage Repair.
PARP Inhibitors for Recurrent Ovarian Carcinoma: Current Treatment Options and Future Perspectives.
PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity.
PARP Inhibitors for the Treatment and Prevention of Breast Cancer.
Parp Inhibitors for the Treatment of Ovarian Cancer.
PARP Inhibitors in Biliary Tract Cancer: A New Kid on the Block?
PARP inhibitors in BRCA gene-mutated ovarian cancer and beyond.
PARP inhibitors in BRCA1-/BRCA2-associated and triple-negative breast cancers.
PARP inhibitors in BRCA1/BRCA2 germline mutation carriers with ovarian and breast cancer.
PARP inhibitors in breast cancer: BRCA and beyond.
PARP inhibitors in breast cancer: Bringing synthetic lethality to the bedside.
PARP Inhibitors in Cancer Diagnosis and Therapy.
PARP inhibitors in cancer therapy: an update.
PARP Inhibitors in Cancer Therapy: Magic Bullets but Moving Targets.
PARP inhibitors in cancer therapy: promise, progress, and puzzles.
PARP inhibitors in cancer therapy: two modes of attack on the cancer cell widening the clinical applications.
PARP inhibitors in cancer: moving beyond BRCA.
PARP Inhibitors in Clinical Use Induce Genomic Instability in Normal Human Cells.
PARP Inhibitors in Endometrial Cancer: Current Status and Perspectives.
PARP Inhibitors in Epithelial Ovarian Cancer: State of Art and Perspectives of Clinical Research.
PARP inhibitors in gastric cancer: beacon of hope.
PARP Inhibitors in Gynecologic Cancers: What Is the Next Big Development?
PARP inhibitors in head and neck cancer: Molecular mechanisms, preclinical and clinical data.
PARP inhibitors in oncology: a new synthetic lethal approach to cancer therapy.
PARP inhibitors in ovarian and other cancers.
PARP Inhibitors in Ovarian Cancer: A Trailblazing and Transformative Journey.
PARP inhibitors in ovarian cancer: An overview of the practice-changing trials.
PARP inhibitors in ovarian cancer: Current status and future promise.
PARP inhibitors in ovarian cancer: evidence for maintenance and treatment strategies.
PARP inhibitors in ovarian cancer: evidence, experience and clinical potential.
PARP inhibitors in ovarian cancer: Sensitivity prediction and resistance mechanisms.
PARP Inhibitors in Ovarian Cancer: The Route to "Ithaca".
PARP Inhibitors in Pancreatic Cancer: From Phase I to Plenary Session.
PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications.
PARP Inhibitors in Prostate and Urothelial Cancers.
PARP Inhibitors in Prostate Cancer—The Preclinical Rationale and Current Clinical Development.
PARP Inhibitors in Reproductive System Cancers: Current Use and Developments.
PARP inhibitors in the management of breast cancer: current data and future prospects.
PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.
PARP Inhibitors in Triple-Negative Breast Cancer Including Those With BRCA Mutations.
PARP inhibitors promote stromal fibroblast activation by enhancing CCL5 autocrine signaling in ovarian cancer.
PARP Inhibitors Refocus for Rebound.
PARP inhibitors synergize with gemcitabine by potentiating DNA damage in non-small-cell lung cancer.
PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation.
PARP inhibitors--current status and the walk towards early breast cancer.
PARP inhibitors.
PARP inhibitors: A new era of targeted therapy.
PARP inhibitors: a tsunami of indications in different malignancies.
PARP inhibitors: an interesting pathway also for Non-Small Cell Lung Cancer?
PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance.
PARP inhibitors: Clinical utility and possibilities of overcoming resistance.
PARP Inhibitors: Extending Benefit Beyond BRCA Mutant Cancers.
PARP inhibitors: its role in treatment of cancer.
PARP Inhibitors: Mechanism of Action and Their Potential Role in the Prevention and Treatment of Cancer.
PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases.
PARP inhibitors: New tools to protect from inflammation.
PARP inhibitors: polypharmacology versus selective inhibition.
PARP inhibitors: review of mechanisms of action and BRCA1/2 mutation targeting.
PARP inhibitors: shifting the paradigm in the treatment of pancreatic cancer.
PARP inhibitors: Synthetic lethality in the clinic.
PARP Inhibitors: The Cornerstone of DNA Repair-Targeted Therapies.
PARP is important for genomic stability but dispensable in apoptosis.
PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling.
PARP Targeted Alpha-Particle Therapy Enhances Response to PD-1 Immune-Checkpoint Blockade in a Syngeneic Mouse Model of Glioblastoma.
PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma.
PARP Theranostic Auger Emitters Are Cytotoxic in BRCA Mutant Ovarian Cancer and Viable Tumors from Ovarian Cancer Patients Enable Ex-Vivo Screening of Tumor Response.
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways.
PARP-1 and PARP-2: New players in tumour development.
PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma.
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts.
Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.
Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment.
PARP-1 depletion in combination with carbon ion exposure significantly reduces MMPs activity and overall increases TIMPs expression in cultured HeLa cells.
PARP-1 expression as a prognostic factor in Desmoid-type fibromatosis.
PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy.
PARP-1 expression in CD34+ leukemic cells in childhood acute lymphoblastic leukemia: relation to response to initial therapy and other prognostic factors.
PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1.
Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer.
PARP-1 induces EMT in non-small cell lung carcinoma cells via modulating the transcription factors Smad4, p65 and ZEB1.
PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma.
PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation.
PARP-1 inhibition induces a late increase in the level of reactive oxygen species in cells after ionizing radiation.
PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity.
PARP-1 inhibition to treat cancer, ischemia, inflammation.
PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53.
PARP-1 inhibition-induced activation of PI-3-kinase-Akt pathway promotes resistance to taxol.
PARP-1 inhibitor modulate ?-catenin signaling to enhance cisplatin sensitivity in cancer cervix.
PARP-1 inhibitors: a novel genetically specific agents for cancer therapy.
PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?
PARP-1 may be involved in angiogenesis in epithelial ovarian cancer.
PARP-1 Overexpression as an Independent Prognostic Factor in Adult Non-M3 Acute Myeloid Leukemia.
PARP-1 promotes tumor recurrence after warm ischemic liver graft transplantation via neutrophil recruitment and polarization.
PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.
PARP-1 protein expression in glioblastoma multiforme.
PARP-1 regulates DNA repair factor availability.
PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesis.
PARP-1 Regulates Estrogen-Dependent Gene Expression in Estrogen Receptor ?-Positive Breast Cancer Cells.
PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation.
PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population.
PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies.
PARP-1 Val762Ala polymorphism is associated with risk of cervical carcinoma.
PARP-1 Val762Ala polymorphism, CagA(+) H. pylori infection and risk for gastric cancer in Han Chinese population.
PARP-1, a determinant of cell survival in response to DNA damage.
PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation.
PARP-1/2 Inhibitor Olaparib Prevents or Partially Reverts EMT Induced by TGF-? in NMuMG Cells.
PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis?
PARP-Targeted Auger Therapy in p53 Mutant Colon Cancer Xenograft Mouse Models.
Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage.
PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma.
PARP1 and CBP lose their footing in cancer.
PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.
PARP1 and phospho-p65 protein expression is increased in human HER2-positive breast cancers.
PARP1 and PRC2 double deficiency promotes BRCA-proficient breast cancer growth by modification of the tumor microenvironment.
PARP1 as a Marker of an Aggressive Clinical Phenotype in Cutaneous Melanoma-A Clinical and an In Vitro Study.
PARP1 Co-Regulates EP300-BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair.
PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells.
PARP1 deficiency protects against hyperglycemia-induced neointimal hyperplasia by upregulating TFPI2 activity in diabetic mice.
PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer.
PARP1 depletion induces RIG-I-dependent signaling in human cancer cells.
PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair.
PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma.
PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models.
PARP1 expression in pediatric central nervous system tumors.
PARP1 expression in soft tissue sarcomas is a poor-prognosis factor and a new potential therapeutic target.
PARP1 gene polymorphisms and neuroblastoma susceptibility in Chinese children.
PARP1 impact on DNA repair of platinum adducts: Preclinical and clinical read-outs.
PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs.
PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1.
PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes-Implications for UV-Induced DNA Repair and Photocarcinogenesis.
PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response.
PARP1 Inhibition Radiosensitizes Models of Inflammatory Breast Cancer to Ionizing Radiation.
PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway.
PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas.
PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1.
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response.
PARP1 Inhibitors: antitumor drug design.
PARP1 is a novel independent prognostic factor for the poor prognosis of chordoma.
PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy.
PARP1 Is Overexpressed in Hematological Malignant Cell Lines: A Framework for Experimental Oncology.
PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ.
PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity.
PARP1 rs1136410 C/C genotype associated with an increased risk of esophageal cancer in smokers.
PARP1 rs1136410 Val762Ala contributes to an increased risk of overall cancer in the East Asian population: a meta-analysis.
PARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy.
PARP1 Stabilizes CTCF Binding and Chromatin Structure To Maintain Epstein-Barr Virus Latency Type.
PARP1 suppresses homologous recombination events in mice in vivo.
PARP1 Suppresses the Transcription of PD-L1 by Poly(ADP-Ribosyl)ating STAT3.
PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors.
PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow.
PARP1 V762A polymorphism affects the prognosis of myelodysplastic syndromes.
PARP1 Val762Ala polymorphism reduces enzymatic activity.
Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives.
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites.
PARP1-mediated PARylation of TonEBP prevents R-loop-associated DNA damage.
PARP1-modulated chromatin remodeling is a new target for cancer treatment.
PARP1-siRNA suppresses human prostate cancer cell growth and progression.
PARP10 Multi-Site Auto- and Histone MARylation Visualized by Acid-Urea Gel Electrophoresis.
PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress.
PARP10 suppresses tumor metastasis through regulation of Aurora A activity.
PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery.
PARP14 promotes the proliferation and gemcitabine chemoresistance of pancreatic cancer cells through activation of NF-?B pathway.
PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation.
PARP1: Structural insights and pharmacological targets for inhibition.
PARP3 comes to light as a prime target in cancer therapy.
PARP3 controls TGF? and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis.
PARP3 interacts with FoxM1 to confer glioblastoma cell radioresistance.
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation.
PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers.
PARPi focus the spotlight on replication fork protection in cancer.
PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness.
PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders.
PARPs in lipid metabolism and related diseases.
Parthanatos and its associated components: Promising therapeutic targets for cancer.
Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice.
Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer.
Partnering with PARP inhibitors in acute myeloid leukemia with FLT3-ITD.
Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer.
Patient Counseling and Management of Symptoms During Olaparib Therapy for Recurrent Ovarian Cancer.
Patients with bi-allelic BRCA1/2 inactivation respond to olaparib treatment across histologic tumor types.
PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer.
PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells.
PCAT-1, a Long Noncoding RNA, Regulates BRCA2 and Controls Homologous Recombination in Cancer.
Pediatric high-grade glioma: identification of poly(ADP-ribose) polymerase as a potential therapeutic target.
PEGylated lipid bilayer-supported mesoporous silica nanoparticle composite for synergistic co-delivery of axitinib and celastrol in multi-targeted cancer therapy.
Persistent depletion of plasma gelsolin (pGSN) after exposure of mice to heavy silicon ions.
Personalized Medicine in Gynecologic Cancer: Fact or Fiction?
Perspectives on PARP inhibitors as pharmacotherapeutic strategies for breast cancer.
Pertussis toxin blocks the inhibitory effect of muscarinic cholinergic agonists on cyclic AMP accumulation and prolactin secretion in GH3 anterior-pituitary tumour cells.
Pertussis toxin-induced hyperacute autoimmune encephalomyelitis in Lewis rats is correlated with increased expression of inducible nitric oxide synthase and tumor necrosis factor alpha.
PET imaging of PARP expression using [18F]olaparib.
PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies.
Pharmacodynamic analyses in a multi-laboratory network: lessons from the poly(ADP-ribose) assay.
Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program.
Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.
Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers.
Pharmacokinetic drug evaluation of niraparib for the treatment of ovarian cancer.
Pharmacokinetic Study of Rucaparib in Patients With Advanced Solid Tumors.
Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis.
Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.
Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency.
Pharmacological Inhibition of Poly(ADP-ribose) Polymerase (PARP) Activity in PARP-1 Silenced Tumour Cells Increases Chemosensitivity to Temozolomide and to a N3-Adenine Selective Methylating Agent.
Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent.
Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis.
Pharmacological methods to transcriptionally modulate double-strand break DNA repair.
Pharmacological targets and molecular mechanisms of plumbagin to treat colorectal cancer: A systematic pharmacology study.
Phase 0 Clinical Trial of the Poly (ADP-Ribose) Polymerase Inhibitor ABT-888 in Patients With Advanced Malignancies.
Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid Tumors.
Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors.
Phase 1 study of veliparib (ABT-888), a poly (ADP-ribose) polymerase inhibitor, with carboplatin and paclitaxel in advanced solid malignancies.
Phase 1/2 trial of talazoparib in combination with temozolomide in children and adolescents with refractory/recurrent solid tumors including Ewing sarcoma: A Children's Oncology Group Phase 1 Consortium study (ADVL1411).
Phase 2 Study of Talazoparib in Patients With Homologous Recombination Repair-Deficient Squamous Cell Lung Cancer: Lung-MAP Substudy S1400G.
Phase I and pharmacokinetic study of veliparib, a PARP inhibitor, and pegylated liposomal doxorubicin (PLD) in recurrent gynecologic cancer and triple negative breast cancer with long-term follow-up.
Phase I clinical study of oral olaparib in pediatric patients with refractory solid tumors: study protocol.
Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in patients with advanced ovarian cancer and other solid malignancies.
Phase I dose-escalation and expansion study of PARP inhibitor, fluzoparib (SHR3162), in patients with advanced solid tumors.
Phase I safety, pharmacokinetic and pharmacodynamic study of the poly (ADP-ribose) polymerase inhibitor veliparib with irinotecan in patients with advanced solid tumors.
Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas.
Phase I study of the PARP inhibitor talazoparib with radiation therapy for locally recurrent gynecologic cancers.
Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.
Phase I study to assess the safety and tolerability of olaparib in combination with bevacizumab in patients with advanced solid tumours.
Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors.
Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non-BRCA1/2-Mutant Cancers.
Phase I, Dose-Escalation, 2-Part Trial of Poly(ADP-Ribose) Polymerase Inhibitor Talazoparib in Patients with Advanced Germline BRCA1/2 Mutations and Selected Sporadic Cancers.
Phase II Study of Olaparib (AZD-2281) After Standard Systemic Therapies for Disseminated Colorectal Cancer.
Phase II trial of veliparib in patients with previously treated BRCA-mutated pancreas ductal adenocarcinoma.
Phosphatase 1 nuclear targeting subunit mediates recruitment and function of poly (ADP-ribose) polymerase 1 in DNA repair.
Phosphatase 1 Nuclear Targeting Subunit, a Novel DNA Repair Partner of PARP1.
Phosphatase and Tensin Homolog Is a Potential Target for Ovarian Cancer Sensitization to Cytotoxic Agents.
Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.
Phospholipase A2 activation in chemotactic peptide-stimulated HL60 granulocytes: synergism between diacylglycerol and Ca2+ in a protein kinase C-independent mechanism.
Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers.
Phosphorylation regulates the interaction and complex formation between wt p53 protein and PARP-1.
Photodynamic therapy induced Fas-mediated apoptosis in human carcinoma cells.
Photodynamic Therapy of Pheophorbide a Inhibits the Proliferation of Human Breast Tumour via Both Caspase-dependent and -independent Apoptotic Pathways in In Vitro and In Vivo Models.
Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice.
Phthalocyanine 4 (Pc 4) photodynamic therapy of human OVCAR-3 tumor xenografts.
Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence.
Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release.
PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA proficient triple negative breast cancer to PARP inhibition.
PI3K-AKT-mTOR inhibitors in breast cancers: From tumor cell signaling to clinical trials.
Pinus Roxburghii essential oil anticancer activity and chemical composition evaluation.
PJ-34 inhibits PARP-1 expression and ERK phosphorylation in glioma-conditioned brain microvascular endothelial cells.
PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R.
PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells.
PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging.
Placental promoter methylation of DNA repair genes and prenatal exposure to particulate air pollution: an ENVIRONAGE cohort study.
Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates.
Platinated benzonaphthyridone is a stronger inhibitor of poly(ADP-ribose) polymerase-1 and a more potent anticancer agent than is the parent inhibitor.
Platinum(IV) prodrugs multiply targeting genomic DNA, histone deacetylases and PARP-1.
Playing on the Dark Side: SMYD3 Acts as a Cancer Genome Keeper in Gastrointestinal Malignancies.
Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer.
PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1).
Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.
PLK1/NF-?B feedforward circuit antagonizes the mono-ADP-ribosyltransferase activity of PARP10 and facilitates HCC progression.
Pol? inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Poly (ADP) ribose polymerase inhibition: A potential treatment of malignant peripheral nerve sheath tumor.
Poly (ADP-ribose) polymerase (PARP) as target for the treatment of epithelial ovarian cancer: what to know.
Poly (ADP-ribose) polymerase (PARP): rationale, preclinical and clinical evidences of its inhibition as breast cancer treatment.
Poly (ADP-ribose) polymerase 1 mRNA levels strongly correlate with the prognosis of myelodysplastic syndromes.
Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue.
Poly (ADP-Ribose) Polymerase 1 Protein Expression in Normal Pancreas and Pancreatic Adenocarcinoma.
Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity.
Poly (adp-ribose) polymerase as a novel therapeutic target in cancer.
Poly (ADP-ribose) polymerase inhibitor efficacy in head and neck cancer.
Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms.
Poly (ADP-Ribose) Polymerase Inhibitor, ABT888, Improved Cisplatin Effect in Human Oral Cell Carcinoma.
Poly (ADP-ribose) polymerase inhibitors combined with other small-molecular compounds for the treatment of ovarian cancer.
Poly (ADP-ribose) Polymerase Inhibitors in Cancer Treatment.
Poly (ADP-ribose) polymerase inhibitors in solid tumours: Systematic review and meta-analysis.
Poly (ADP-ribose) polymerase inhibitors in the management of ovarian cancer.
Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells.
Poly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond.
Poly (ADP-ribose) polymerase-1 (PARP1) as a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.
Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy.
Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma.
Poly (ADP-ribose) polymerase-1 Inhibition: Preclinical and Clinical Development of Synthetic Lethality.
Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation.
Poly (ADP-Ribose) Polymerases (PARPs) and PARP Inhibitor-Targeted Therapeutics.
Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer.
Poly (ADP-Ribosyl) Polymerase 1 Inhibitors: A Patent Review.
Poly adenosine diphosphate-ribosylation, a promising target for colorectal cancer treatment.
Poly ADP-ribose polymerase (PARP) inhibitors transiently protect leukemia cells from alkylating agent induced cell death by three different effects.
Poly ADP-ribose polymerase inhibition suppresses cisplatin toxicity in chronic myeloid leukemia cells.
Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models.
Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region.
Poly(adenosine diphosphate-ribose) polymerase expression in serous ovarian carcinoma: correlation with p53, MIB-1, and outcome.
Poly(Adenosine diphosphate-ribose) polymerase inhibitors in cancer treatment.
Poly(adenosine diphosphate-ribosylation) of nuclear matrix proteins in alkylating agent resistant and sensitive cell lines.
Poly(ADP-ribose) and carcinogenesis.
Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions.
Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) - Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy.
Poly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues.
Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis.
Poly(ADP-ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic.
Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy.
Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila.
Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1.
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors.
Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression.
Poly(ADP-Ribose) polymerase 1: a therapeutic hope in gynecologic cancers.
Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis.
Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression.
Poly(ADP-ribose) polymerase activity and inhibition in cancer.
Poly(ADP-ribose) polymerase and cancer: in relation to the lectures presented by Dr Gilbert de Murcia.
Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update.
Poly(ADP-ribose) polymerase as a novel regulator of 17?-estradiol-induced cell growth through a control of the estrogen receptor/IGF-1 receptor/PDZK1 axis.
Poly(ADP-ribose) polymerase from Ehrlich ascites tumor cells. Properties of the purified polymerase.
Poly(ADP-ribose) polymerase gene expression status and genomic instability in human breast cancer.
Poly(ADP-Ribose) Polymerase in Cervical Cancer Pathogenesis: Mechanism and Potential Role for PARP Inhibitors.
Poly(ADP-ribose) polymerase in DNA damage-response pathway: implications for radiation oncology.
Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis.
Poly(ADP-ribose) polymerase inhibition as a model for synthetic lethality in developing radiation oncology targets.
Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent.
Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity?
Poly(ADP-ribose) polymerase inhibition reduces tumor necrosis factor-induced inflammatory response in rheumatoid synovial fibroblasts.
Poly(ADP-Ribose) Polymerase Inhibition Synergizes with 5-Fluorodeoxyuridine but not 5-Fluorouracil in Ovarian Cancer Cells.
Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer?
Poly(ADP-ribose) polymerase inhibition: past, present and future.
Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells.
Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors.
Poly(ADP-ribose) polymerase inhibitors as cancer therapy.
Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics.
Poly(ADP-ribose) polymerase inhibitors in cancer treatment: a clinical perspective.
Poly(ADP-ribose) polymerase inhibitors in prostate and urothelial cancer.
Poly(ADP-Ribose) Polymerase Inhibitors in Prostate Cancer: Molecular Mechanisms, and Preclinical and Clinical Data.
Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer.
Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression.
Poly(ADP-ribose) polymerase is a B-MYB coactivator.
Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.
Poly(ADP-ribose) polymerase, a potential target for drugs: Cellular regulatory role of the polymer and the polymerase protein mediated by catalytic and macromolecular colligative actions (Review).
Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors in cancer chemotherapy.
Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers.
Poly(ADP-ribose) polymerase-1 (PARP1) and p53 labelling index correlates with tumour grade in meningiomas.
Poly(ADP-ribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA.
Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders.
Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks.
Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.
Poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide enhances apoptosis induction by platinum complexes in cisplatin-resistant tumor cells.
Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.
Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury.
Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation.
Poly(ADP-ribose) polymerase-1 mRNA expression in human breast cancer: a meta-analysis.
Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines.
Poly(ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein.
Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation.
Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis.
Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications.
Poly(ADP-ribose) polymerases: managing genome stability.
Poly(ADP-ribose)-dependent regulation of Snail1 protein stability.
Poly(ADP-Ribose)-Polymerase-Catalyzed Hydrolysis of NAD(+): QM/MM Simulation of the Enzyme Reaction.
Poly(ADP-ribose): a co-regulator of DNA methylation?
Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy.
Poly(ADP-ribose)polymerase inhibition - where now?
Poly(ADP-ribose)polymerase inhibition decreases angiogenesis.
Poly(ADP-ribose)polymerase-1 (PARP-1) in carcinogenesis: potential role of PARP inhibitors in cancer treatment.
Poly(ADP-ribose)polymerase1: A potential molecular marker to identify cancer during colposcopy procedures.
Poly(ADP-ribosyl)ation in carcinogenesis.
Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease.
Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription.
Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.
Poly(ADP-ribosyl)ation polymerases: mechanism and new target of anticancer therapy.
Poly(ADP-ribosylation) and neoplastic transformation:Effect of PARP inhibitors.
Poly(ADP-Ribosylation) in Age-Related Neurological Disease.
Poly-(ADP-ribose) polymerase inhibitors: paradigm shift in the first-line treatment of newly diagnosed advanced ovarian cancer.
Poly-(ADP-ribose)-polymerase inhibitors as radiosensitizers: a systematic review of pre-clinical and clinical human studies.
Poly-ADP ribosylation in DNA damage response and cancer therapy.
Poly-ADP-ribose polymerases (PARPs) as a therapeutic target in the treatment of selected cancers.
Poly-ADP-ribosyl-polymerase inhibitor resistance mechanisms and their therapeutic implications.
Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy.
Poly-l-Lysine inhibits VEGF and c-Myc mediated tumor-angiogenesis and induces apoptosis in 2D and 3D tumor microenvironment of both MDA-MB-231 and B16F10 induced mice model.
PolyADP-ribosylation and cancer.
Polyclonal BRCA2 mutations following carboplatin treatment confer resistance to the PARP inhibitor rucaparib in a patient with mCRPC: a case report.
Polylysine-modified polyethylenimine inducing tumor apoptosis as an efficient gene carrier.
Polymer-lipid hybrid nanovesicle-enabled combination of immunogenic chemotherapy and RNAi-mediated PD-L1 knockdown elicits antitumor immunity against melanoma.
Polymorphisms of DNA repair genes: ADPRT, XRCC1, and XPD and cancer risk in genetic epidemiology.
Population Pharmacokinetics of Talazoparib in Patients With Advanced Cancer.
Population-Attributable Risk Proportion of Clinical Risk Factors for Breast Cancer.
Positive transcriptional regulation of the human micro opioid receptor gene by poly(ADP-ribose) polymerase-1 and increase of its DNA binding affinity based on polymorphism of G-172 -> T.
Positron-Emission Tomographic Imaging of a Fluorine 18-Radiolabeled Poly(ADP-Ribose) Polymerase 1 Inhibitor Monitors the Therapeutic Efficacy of Talazoparib in SCLC Patient-Derived Xenografts.
Possible role of poly(ADP-ribose) polymerase on the early stage of liver carcinogenesis by diethylnitrosamine in rats.
Post-transcriptional regulation by poly(ADP-ribosyl)ation of the RNA-binding proteins.
Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling.
Post-Traumatic Brain Injury: Genetic Susceptibility to Outcome.
Post-traumatic caspase-3 expression in the adjacent areas of growth plate injury site: a morphological study.
Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes.
Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective.
Potential Use of Inhibitors of Tankyrases and PARP-1 as Treatment for Cancer and Other Diseases.
Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.
Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.
Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers.
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Preclinical and first-in-human-brain-cancer applications of [18F]poly (ADP-ribose) polymerase inhibitor PET/MR.
Preclinical evaluation of olaparib and metformin combination in BRCA1 wildtype ovarian cancer.
Preclinical evaluation of radiation therapy of BRCA1-associated mammary tumors using a mouse model.
Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer.
Preclinical evaluation of the PARP inhibitor, olaparib, in combination with cytotoxic chemotherapy in pediatric solid tumors.
Preclinical modeling of a phase 0 clinical trial: qualification of a pharmacodynamic assay of poly (ADP-ribose) polymerase in tumor biopsies of mouse xenografts.
Preclinical rationale for combination of crizotinib with mitomycin C for the treatment of advanced colorectal cancer.
Predicting enhanced cell killing through PARP inhibition.
Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors.
Predictive biomarkers for cancer therapy with PARP inhibitors.
Predictive value of epithelial-mesenchymal-transition (EMT) signature and PARP-1 in prostate cancer radioresistance.
Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine.
Preferential involvement of Go and Gz proteins in mediating rat natural killer cell lysis of allogeneic and tumor target cells.
Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer.
Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition-mediated genomic instability, inflammatory signaling and cytotoxicity in BRCA2-deficient cancer cells.
Preserving genome integrity in human cells via DNA double-strand break repair.
Prevalence of DNA Repair Gene Mutations in Blood and Tumor Tissue and Impact on Prognosis and Treatment in HNSCC.
Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Homologous Recombination in Patients with Triple-Negative and Hereditary Non-Triple-Negative Breast Cancers.
Prevalence of Homologous Recombination Pathway Gene Mutations in Melanoma: Rationale for a New Targeted Therapeutic Approach.
Prevalence of Tissue BRCA Gene Mutation in Ovarian, Fallopian Tube, and Primary Peritoneal Cancers: A Multi-Institutional Study.
Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer.
Prexasertib, a checkpoint kinase inhibitor: from preclinical data to clinical development.
Probing PARP1-inhibitor complexes for the development of novel inhibitors.
Probing the Conformational Changes Associated with DNA Binding to PARP1.
Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling.
Production and release of tumor necrosis factor alfa, interleukin-1B and interleukin-6 by human mononuclear leukocytes stimulated with pertussis toxin.
Profile of veliparib and its potential in the treatment of solid tumors.
Progress in the treatment of ovarian cancer-lessons from homologous recombination deficiency-the first 10 years.
Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.
Prolonged response to treatment based on cell-free DNA analysis and molecular profiling in three patients with metastatic cancer: a case series.
Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors.
Prophylactic window therapy with the clinical poly(ADP-ribose) polymerase inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice.
Prostate Cancer Transcriptomic Subtypes.
Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
Protective Effects of Cilostazol against Transient Focal Cerebral Ischemia and Hemorrhagic Transformation.
Protective effects of the ethanolic extract of Melia toosendan fruit against colon cancer.
Protein expression of DNA damage repair proteins dictates response to topoisomerase and PARP inhibitors in triple-negative breast cancer.
Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation.
Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts.
Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets.
Proteomic Analysis of the Downstream Signaling Network of PARP1.
Proteomic Studies on the Management of High-Grade Serous Ovarian Cancer Patients: A Mini-Review.
PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy.
PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy.
Purification of poly(ADP-ribose) polymerase from Ehrlich ascites tumor cells by chromatography on DNA-agarose.
Putting poly (ADP-ribose) polymerase and other DNA repair inhibitors into clinical practice.
Pyrosequencing analysis of BRCA1 methylation level in breast cancer cells.
Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair.
QSAR study of 2-(1-Propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide as PARP inhibitors for treatment of cancer.
Quantification of cellular poly(ADP-ribosyl)ation by stable isotope dilution mass spectrometry reveals tissue- and drug-dependent stress response dynamics.
Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies.
Quantitative correlation between cellular proliferation and nuclear poly (ADP-ribose) polymerase (PARP-1).
Quartz Crystal Microbalance Detection of Poly(ADP-ribose) Polymerase-1 Based on Gold Nanorods Signal Amplification.
Quercetin-3-O-(2"-galloyl)-?-l-rhamnopyranoside prevents TRAIL-induced apoptosis in human keratinocytes by suppressing the caspase-8- and Bid-pathways and the mitochondrial pathway.
Racial and tissue-specific cancer risk associated with PARP1 (ADPRT) Val762Ala polymorphism: a meta-analysis.
Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma.
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.
RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer.
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status.
RAD51C-deficient cancer cells are highly sensitive to the poly (ADP-ribose) polymerase inhibitor, olaparib.
RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination.
RAD52 as a Potential Target for Synthetic Lethality-Based Anticancer Therapies.
Radiation-induced synthetic lethality: combination of poly(ADP-ribose) polymerase and RAD51 inhibitors to sensitize cells to proton irradiation.
Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins.
Radiosensitivity and Induction of Apoptosis by High LET Carbon Ion Beam and Low LET Gamma Radiation: A Comparative Study.
Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors.
Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells.
Radiosensitization by PARP inhibition to proton beam irradiation in cancer cells.
Radiosensitization by the PARP inhibitor olaparib in BRCA1-proficient and deficient high-grade serous ovarian carcinomas.
Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis.
Radiosensitization Effect of PARP Inhibition in Cells Exposed to Low and High LET Radiation.
Radiosensitization effects of nicotinamide on malignant and normal mouse tissue.
Radiosensitization of human T-cell leukemia by thymidine and 41.8 degrees C hyperthermia in vitro.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Radiosynthesis and Evaluation of Talazoparib and Its Derivatives as PARP-1-Targeting Agents.
RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.
Randomised phase II trial of olaparib, chemotherapy or olaparib and cediranib in patients with platinum-resistant ovarian cancer (OCTOVA): a study protocol.
Randomized Trial of Oral Cyclophosphamide and Veliparib in High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers, or BRCA-Mutant Ovarian Cancer.
Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer.
Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.
Rapamycin-resistant PARP1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis (LAM).
Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.
Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing.
Rapid Progression of Metastatic Pancreatic Adenocarcinoma During Platinum-Based Therapy in a Patient Harboring a Pathogenic BRCA2 Germline Variant.
Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1.
Rare mutations in XRCC2 increase the risk of breast cancer.
RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?
Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.
Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP.
Rationale for PARP inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.
RB Regulates DNA Double Strand Break Repair Pathway Choice by Mediating CtIP Dependent End Resection.
RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells.
Re-evaluating PARP1 inhibitor in cancer.
Re: Expression of Nuclear Matrix Proteins Binding Matrix Attachment Regions in Prostate Cancer. PARP-1: New Player in Tumor Progression.
Re: Konrad H. Stopsack. Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.09.024.
Recent advancements in PARP inhibitors-based targeted cancer therapy.
Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.
Recent Advances in Enhancing the Therapeutic Index of PARP Inhibitors in Breast Cancer.
Recent development in the discovery of PARP inhibitors as anticancer agents: a patent update (2016-2020).
Recent Study of Dual HDAC/PARP Inhibitor for the Treatment of Tumor.
Reciprocal positive selection for weakness - preventing olaparib resistance by inhibiting BRCA2.
Recombinant IFN-alpha2b treatment activates poly (ADPR) polymerase-1 (PARP-1) in KB cancer cells.
RecQ helicases and PARP1 team up in maintaining genome integrity.
RECQ1 Promotes Stress Resistance and DNA Replication Progression Through PARP1 Signaling Pathway in Glioblastoma.
Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer.
Reduced ADP-ribosylation by PARP1 natural polymorphism V762A and by PARP1 inhibitors enhance Hepatitis B virus replication.
Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition.
Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition.
Reduced stability of regularly spliced but not alternatively spliced p53 protein in PARP-deficient mouse fibroblasts.
Reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 and PARP-2 knockout mice.
Reduction of tumor hypoxia and inhibition of DNA repair by nicotinamide after irradiation of SCCVII murine tumors and normal tissues.
Refinement of high-risk endometrial cancer classification using DNA damage response biomarkers: a TransPORTEC initiative.
Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells.
Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis.
Regulation of DNA double-strand break repair pathway choice: a new focus on 53BP1.
Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation.
Regulation of NF-?B signalling by the mono-ADP-ribosyltransferase ARTD10.
Regulation of p53 sequence-specific DNA-binding by covalent poly(ADP-ribosyl)ation.
Regulation of poly(ADP-Ribose) polymerase 1 functions by post-translational modifications.
Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy?
Regulation of the human poly(ADP-ribose) polymerase promoter by the ETS transcription factor.
Regulatory changes of apoptotic factors in the bovine corpus luteum after induced luteolysis.
Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.
Relevance of poly (ADP-ribose) polymerase inhibitors in prostate cancer.
Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells.
Replication fork stability confers chemoresistance in BRCA-deficient cells.
Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells.
Replication stress response in cancer stem cells as a target for chemotherapy.
Replication Stress: An Achilles' Heel of Glioma Cancer Stem-like Cells.
Replication-induced DNA damage after PARP inhibition causes G2 delay, and cell line-dependent apoptosis, necrosis and multinucleation.
Reply to Johann S. de Bono, Maha Hussain, and Jinyu Kang's Letter to the Editor re: Konrad H. Stopsack. Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.09.024.
Repositioning PARP inhibitors in the treatment of thoracic malignancies.
Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition.
Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis.
Repurposing of mTOR Complex Inhibitors Attenuates MCL-1 and Sensitizes to PARP Inhibition.
Requirement of down-regulation of NAD+ ADP-ribosyltransferase for the interferon-gamma-induced activation process of murine macrophage tumor cells.
Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor.
Research progress of PARP inhibitor monotherapy and combination therapy for endometrial cancer.
Research Progress on PARP14 as a Drug Target.
Research progress on the association between environmental pollutants and the resistance mechanism of PARP inhibitors in ovarian cancer.
Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition.
Resistance to PARP-Inhibitors in Cancer Therapy.
Resistance to second-generation androgen receptor antagonists in prostate cancer.
Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase.
Response of Breast Cancer Cells to PARP Inhibitors Is Independent of BRCA Status.
Response of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation.
Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib: A case report.
Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation.
Response of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition.
Response prediction biomarkers and drug combinations of PARP inhibitors in prostate cancer.
Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance.
Response to olaparib in metastatic castration-resistant prostate cancer with germline BRCA2 mutation: a case report.
Response to olaparib in metastatic lung adenocarcinoma with germline BRCA2 mutation: a case report.
Restoration of Temozolomide Sensitivity by PARP Inhibitors in Mismatch Repair Deficient Glioblastoma is Independent of Base Excision Repair.
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis.
Restored replication fork stabilization, a mechanism of PARP inhibitor resistance, can be overcome by cell cycle checkpoint inhibition.
Results of a phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA-defective tumours.
Resurrection of PARP Inhibitors in Breast Cancer.
Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage.
Resveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3-dependent pathway.
Retrospective screening of microarray data to identify candidate IFN-inducible genes in a HTLV-1 transformed model.
REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
Revealing biomarkers associated with PARP inhibitors based on genetic interactions in cancer genome.
Reversal of acquired cisplatin resistance by nicotinamide in vitro and in vivo.
Reverse Screening Bioinformatics Approach to Identify Potential Anti Breast Cancer Targets Using Thymoquinone from Neutraceuticals Black Cumin Oil.
Reverse the Resistance to PARP Inhibitors.
Reversing oncogenic transformation with iron chelation.
Reversion Mutations with Clinical Use of PARP Inhibitors: Many Genes, Many Versions.
Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase.
Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.
Reviewing the characteristics of BRCA and PALB2-related cancers in the precision medicine era.
Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas.
Rho/ROCK pathway as a target of tumor therapy.
RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance.
Risk of fatigue and anemia in patients with advanced cancer treated with olaparib: A meta-analysis of randomized controlled trials.
Risk of fatigue with PARP inhibitors in cancer patients: a systematic review and meta-analysis of 29 phase II/III randomized controlled trials.
Risk of pneumonitis in cancer patients treated with PARP inhibitors: A meta-analysis of randomized controlled trials and a pharmacovigilance study of the FAERS database.
Risk of selected gastrointestinal and hepatic toxicities in cancer patients treated with PARP inhibitors: A systematic review and meta-analysis.
Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials.
Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: results of monotherapy and combination therapy trials.
Risk-Associated Long Noncoding RNA FOXD3-AS1 Inhibits Neuroblastoma Progression by Repressing PARP1-Mediated Activation of CTCF.
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.
RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1.
Role of Akt Activation in PARP Inhibitor Resistance in Cancer.
Role of Biomarkers in the Development of PARP Inhibitors.
Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors.
Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review.
Role of nicotinamide in DNA damage, mutagenesis, and DNA repair.
Role of PARP Inhibitors in Cancer Biology and Therapy.
Role of PARP-1 and PARP-2 in the expression of apoptosis-regulating genes in HeLa cells.
Role of PARP-1 in prostate cancer.
Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age.
Role of PARP1 regulation in radiation-induced rescue effect.
Role of Poly (ADP-Ribose) Polymerase inhibitors beyond BReast CAncer Gene-mutated ovarian tumours: definition of homologous recombination deficiency?
Role of poly (ADP-ribose) polymerase-1 and cytokines in acute renal injury in elderly Chinese patients with diabetes mellitus.
Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.
Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors.
Role of the ERK pathway for oxidant-induced parthanatos in human lymphocytes.
Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis.
Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase-1 in sensitization of fibroblasts to tumor necrosis factor-induced apoptosis.
Rosiglitazone enhances the radiosensitivity of p53-mutant HT-29 human colorectal cancer cells.
Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice.
Rotundarpene attenuates cholesterol oxidation product-induced apoptosis by suppressing the mitochondrial pathway and the caspase-8- and bid-dependent pathways.
Rotundarpene prevents TRAIL-induced apoptosis in human keratinocytes by suppressing the caspase-8- and Bid-pathways and the mitochondrial pathway.
Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.
Rucaparib Monotherapy in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation.
Rucaparib: First Global Approval.
Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms.
Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells.
Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study.
Safety and dose modification for patients receiving niraparib.
Safety and tolerability of the olaparib tablet formulation in Japanese patients with advanced solid tumours.
Safety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: a phase I study.
Safety profile of poly (ADP-ribose) polymerase (PARP) inhibitors in cancer: a network meta-analysis of randomized controlled trials.
Safety, pharmacokinetics, and preliminary efficacy of the PARP inhibitor talazoparib in Japanese patients with advanced solid tumors: phase 1 study.
Sapphyrins induce apoptosis in hematopoietic tumor-derived cell lines and show in vivo antitumor activity.
Sarcophine-diol, a skin cancer chemopreventive agent, inhibits proliferation and stimulates apoptosis in mouse melanoma b(16)f(10) cell line.
Schlafen-11 expression is associated with immune signatures and basal-like phenotype in breast cancer.
Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells.
Secondary and tertiary ovarian cancer recurrence: what is the best management?
Secondary BRCA1 and BRCA2 alterations and acquired chemoresistance.
Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor.
Secondary mutations of BRCA1/2 and drug resistance.
Secretory phospholipase A(2) induces apoptosis through TNF-alpha and cytochrome c-mediated caspase cascade in murine macrophage RAW 264.7 cells.
Segregation analysis of the BRCA2 c.9227G>T variant in multiple families suggests a pathogenic role in breast and ovarian cancer predisposition.
Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.
Selective involvement of caspase-3 in ceramide induced apoptosis in AK-5 tumor cells.
Selective modulation by PARP-1 of HIF-1?-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions.
Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.
Selective Small Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG).
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K.
Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function.
Selenadiazole derivatives inhibit angiogenesis-mediated human breast tumor growth through suppressing VEGFR2-mediated ERK and AKT signaling pathway.
Selenium effects on prostate cell growth.
Sensitivity to inhibition of DNA repair by Olaparib in novel oropharyngeal cancer cell lines infected with Human Papillomavirus.
Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair.
Sensitization by glycerol for CDDP-therapy against human cultured cancer cells and tumors bearing mutated p53 gene.
Sensitization of cancer cells through reduction of total Akt and downregulation of salinomycin-induced pAkt, pGSk3?, pTSC2, and p4EBP1 by cotreatment with MK-2206.
Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules.
Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair.
Sensitizing effects of an organovanadium compound during adjuvant therapy with cyclophosphamide in a murine tumor model.
Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2.
Sensitizing HR-proficient cancers to PARP inhibitors.
Sequences and combinations of multifaceted therapy in advanced prostate cancer.
Sequential Inhibition of PARP and WEE1 Minimizes Toxicity.
Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.
Serine-linked PARP1 auto-modification controls PARP inhibitor response.
ShallowHRD: detection of homologous recombination deficiency from shallow whole genome sequencing.
Shaping the BRCAness mutational landscape by alternative double-strand break repair, replication stress and mitotic aberrancies.
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.
Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation.
Shrimp shells extracted chitin in silver nanoparticle synthesis: Expanding its prophecy towards anticancer activity in human hepatocellular carcinoma HepG2 cells.
ShRNA-mediated silencing of Gli2 gene inhibits proliferation and sensitizes human hepatocellular carcinoma cells towards TRAIL-induced apoptosis.
Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles.
Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells.
Silencing of CHFR Sensitizes Gastric Carcinoma to PARP Inhibitor Treatment.
Silencing of HSulf-2 expression in MCF10DICS.com cells attenuate ductal carcinoma in situ progression to invasive ductal carcinoma in vivo.
Similar response rates and survival with PARP inhibitors for patients with solid tumors harboring somatic versus Germline BRCA mutations: a Meta-analysis and systematic review.
Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells.
Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples.
Simultaneous measurement of perillyl alcohol and its metabolite perillic acid in plasma and lung after inhalational administration in Wistar rats.
Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells.
Single cell resolution in vivo imaging of DNA damage following PARP inhibition.
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
Single-particle analysis of full-length human poly(ADP-ribose) polymerase 1.
Single-Particle Assay of Poly(ADP-ribose) Polymerase-1 Activity with Dark-Field Optical Microscopy.
Sirtuins are Unaffected by PARP Inhibitors Containing Planar Nicotinamide Bioisosteres.
Sirtuins in dermatology: applications for future research and therapeutics.
Slug promotes survival during metastasis through suppression of Puma-mediated apoptosis.
Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.
Small Molecule Microarray Based Discovery of PARP14 Inhibitors.
Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells.
Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics.
SMURF2-mediated ubiquitin signaling plays an essential role in the regulation of PARP1 PARylating activity, molecular interactions, and functions in mammalian cells.
Soft tissue sarcomas: new opportunity of treatment with PARP inhibitors?
Somatic BRCA1/2 Recovery as a Resistance Mechanism After Exceptional Response to Poly (ADP-ribose) Polymerase Inhibition.
Somatic mRNA Analysis of BRCA1 Splice Variants Provides a Direct Theranostic Impact on PARP Inhibitors.
Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer.
Somatic mutations in the BRCA1 gene in Chinese women with sporadic breast cancer.
Sonodynamic treatment as an innovative bimodal anticancer approach: shock wave-mediated tumor growth inhibition in a syngeneic breast cancer model.
SP600125 overcomes antimitotic drug-resistance in cancer cells by increasing apoptosis with independence of P-gp inhibition.
Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease.
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.
Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase.
Spirooxindole derivative SOID-8 induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells.
Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity.
STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes.
State-of-the-art strategies for targeting the DNA damage response in cancer.
Stepwise development of structure-activity relationship of diverse PARP-1 inhibitors through comparative and validated in silico modeling techniques and molecular dynamics simulation.
Stereoisomers of Astaxanthin Inhibit Human Colon Cancer Cell Growth by Inducing G2/M Cell Cycle Arrest and Apoptosis.
Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib.
Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity.
Strategies for H-score normalization of preanalytical technical variables with potential utility to immunohistochemical-based biomarker quantitation in therapeutic reponse diagnostics.
Strategies towards more effective anticancer therapies: targeting DNA damage response pathways.
Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells.
Stromal cell protection of B-lineage acute lymphoblastic leukemic cells during chemotherapy requires active Akt.
Structural basis for allosteric PARP-1 retention on DNA breaks.
Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.
Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.
Structural Implications for Selective Targeting of PARPs.
Structural requirements of some 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide derivatives as poly (ADP-ribose) polymerase (PARP) for the treatment of cancer: QSAR approach.
Structural Requirements of Some 2-(1-Propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide Derivatives as Poly (ADP-Ribose) Polymerase (PARP) for the Treatment of Cancer: QSAR Approach.
Structurally related antitumor effects of flavanones in vitro and in vivo: involvement of caspase 3 activation, p21 gene expression, and reactive oxygen species production.
Structure based pharmacophore study to identify possible natural selective PARP-1 trapper as anti-cancer agent.
Structure elucidation and biological activity of two new trichothecenes from an endophyte, Myrothecium roridum.
Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter.
Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes.
Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking and Biological Evaluation for Identification of Potential Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors.
Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors.
Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance.
Studying Therapy Response and Resistance in Mouse Models for BRCA1-Deficient Breast Cancer.
Stumbling blocks on the path to personalized medicine in breast cancer: the case of PARP inhibitors for BRCA1/2-associated cancers.
Su Yang Decoction induces human colon carcinoma cell apoptosis by activating caspases.
Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer.
Successes and Challenges of PARP Inhibitors in Cancer Therapy.
Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization.
Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences.
Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis.
Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitors.
Suppression of NF-kappa B survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL.
Suppression of proliferation and migration in highly-metastatic lung cancer cells as well as tumor growth by a new synthesized compound TBrC and its molecular mechanisms of action.
Suppression of tumor growth using a recombinant adenoviral vector carrying the dominant-negative mutant gene Survivin-D53A in a nude mice model.
Survival and proliferation of cells expressing caspase-uncleavable Poly(ADP-ribose) polymerase in response to death-inducing DNA damage by an alkylating agent.
Survivin contributes to DNA repair by homologous recombination in breast cancer cells.
Sustained Complete Response to Cytotoxic Therapy and the PARP Inhibitor Veliparib in Metastatic Castration-Resistant Prostate Cancer - A Case Report.
Sustained Release Talazoparib Implants for Localized Treatment of
Sustained, local delivery of the PARP inhibitor talazoparib prevents the development of mammary gland hyperplasia in Brca1-deficient mice.
Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells.
Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo.
Synergism between ATM and PARP1 Inhibition Involves DNA Damage and Abrogating the G2 DNA Damage Checkpoint.
Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells.
Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program.
Synergistic Anti-Tumour Effect of Syk Inhibitor and Olaparib in Squamous Cell Carcinoma: Roles of Syk in EGFR Signalling and PARP1 Activation.
Synergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase.
Synergistic anticancer effects of combined ?-tocotrienol and oridonin treatment is associated with the induction of autophagy.
Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-Ribose) polymerase inhibition, gemcitabine, and cisplatin.
Synergistic Cytotoxic Effect of Busulfan and the PARP Inhibitor Veliparib in Myeloproliferative Neoplasms.
Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells.
Synergistic Effects of Olaparib and DNA-damaging Agents in Oesophageal Squamous Cell Carcinoma Cell Lines.
Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells.
Synergistic induction of apoptosis by combination treatment with mesupron and auranofin in human breast cancer cells.
Synergistic inhibition of hepatocellular carcinoma growth by cotargeting chromatin modifying enzymes and poly (ADP-ribose) polymerases.
Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells.
Synergistic loss of prostate cancer cell viability by coinhibition of HDAC and PARP.
Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation.
Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition.
Synergistic tumor suppression by adenovirus-mediated inhibitor of growth 4 and interleukin-24 gene cotransfer in hepatocarcinoma cells.
Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(II)(salicylaldiminato)(DMSO or Picolino)Cl complexes.
Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Part 2.
Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors.
Synthesis and Cytotoxicity Studies of Bioactive Benzofurans from Lavandula agustifolia and Modified Synthesis of Ailanthoidol, Homoegonol, and Egonol.
Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor.
Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents.
Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo.
Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent.
Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma.
Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors.
Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities.
Synthesis, Bacteriostatic and Anticancer Activity of Novel Phenanthridines Structurally Similar to Benzo[c]phenanthridine Alkaloids.
Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells.
Synthesis, Cytotoxicity, and Mechanistic Investigation of Platinum(IV) Anticancer Complexes Conjugated with Poly(ADP-ribose) Polymerase Inhibitors.
Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors.
Synthesis, [¹?F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography.
Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling.
Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis.
Synthetic lethal interactions for the development of cancer therapeutics: biological and methodological advancements.
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.
Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition.
Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors.
Synthetic lethal therapies for cancer: what's next after PARP inhibitors?
Synthetic Lethality - Its Current Application and Potential in Oncological Treatment.
Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors.
Synthetic lethality and cancer: cohesin and PARP at the replication fork.
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer.
Synthetic Lethality in Ovarian Cancer.
Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators.
Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells.
Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent.
Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-?
Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.
Synthetic lethality: exploiting the addiction of cancer to DNA repair.
Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells.
Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment.
Systematic inhibitor selectivity between PARP1 and PARP2 enzymes: Molecular implications for ovarian cancer personalized therapy.
Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma.
Systemic delivery of axitinib with nanohybrid liposomal nanoparticles inhibits hypoxic tumor growth.
Systemic DNA damage response and metabolic syndrome as a premalignant state.
Systemic therapy options in BRCA mutation-associated breast cancer.
Systems analysis of dynamic transcription factor activity identifies targets for treatment in olaparib resistant cancer cells.
Systems approach to rational combination therapy: PARP inhibitors.
SYUNZ-16, a newly synthesized alkannin derivative, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of AKT/FOXO signal pathway.
Talazoparib Is a Potent Radiosensitizer in Small Cell Lung Cancer Cell Lines and Xenografts.
Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): an open-label, phase 2 trial.
Tankyrase as a Novel Molecular Target in Cancer and Fibrotic Diseases.
Tankyrase inhibition augments neuronal insulin sensitivity and glucose uptake via AMPK-AS160 mediated pathway.
Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-?-Catenin Signaling.
Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience.
Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities.
Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression.
Targeted brain tumor radiotherapy using an Auger emitter.
Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
Targeted molecular therapies for ovarian cancer: an update and future perspectives (Review).
Targeted radiosensitization of ETS fusion-positive prostate cancer through PARP1 inhibition.
Targeted therapies in epithelial ovarian cancer: Molecular mechanisms of action.
Targeted therapies in gynaecological cancers.
Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence.
Targeted Therapy and Immune Therapy for Small Cell Lung Cancer.
Targeted Therapy for Brain Tumours: Role of PARP Inhibitors.
Targeted Therapy for Breast Cancer Prevention.
Targeted therapy for breast cancer.
Targeted therapy for cancer using PARP inhibitors.
Targeted therapy for gynecologic cancers: Toward the era of precision medicine.
Targeted therapy for ovarian cancer: the rapidly evolving landscape of PARP inhibitor use.
Targeting ATR in cancer medicine.
Targeting autophagy potentiates the anti-tumor effect of PARP inhibitor in pediatric chronic myeloid leukemia.
Targeting autophagy reverses de novo resistance in homologous recombination repair proficient breast cancers to PARP inhibition.
Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.
Targeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-ribose) polymerase inhibition.
Targeting cervical cancer: Is there a role for poly (ADP-ribose) polymerase inhibition?
Targeting Cyclin-Dependent Kinases for Treatment of Gynecologic Cancers.
Targeting dePARylation for cancer therapy.
Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies.
Targeting Different Pathways Using Novel Combination Therapy in Triple Negative Breast Cancer.
Targeting DNA Damage Repair Pathways in Pancreatic Adenocarcinoma.
Targeting DNA damage response in cancer therapy.
Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints.
Targeting DNA repair in breast cancer: A clinical and translational update.
Targeting DNA Repair in Cancer: Beyond PARP Inhibitors.
Targeting DNA repair to drive immune responses: it's time to reconsider the strategy for clinical translation.
Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer.
Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies.
Targeting DNA Repair: The Role of PARP Inhibition in the Treatment of Castration-Resistant Prostate Cancer.
Targeting epidermal growth factor receptor/human epidermal growth factor receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder carcinoma.
Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy.
Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors.
Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.
Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications.
Targeting Nrf2 in healthy and malignant ovarian epithelial cells: Protection versus promotion.
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.
Targeting PARP in Prostate Cancer: Novelty, Pitfalls, and Promise.
Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.
Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer.
Targeting PARP1 in XRCC1 deficient sporadic invasive breast cancer or pre-invasive ductal carcinoma in situ induces synthetic lethality and chemoprevention.
Targeting poly (ADP) ribose polymerase I (PARP-1) and PARP-1 interacting proteins for cancer treatment.
Targeting poly(ADP-ribose) polymerase activity for cancer therapy.
Targeting poly(ADP-ribose) polymerase-1 as a promising approach for immunomodulation in multiple sclerosis?
Targeting Poly(ADP-Ribose) Polymerase: A Two-Armed Strategy for Cancer Therapy.
Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy.
Targeting progastrin enhances radiosensitization of colorectal cancer cells.
Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or BRCA1 Alteration.
Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality.
Targeting the ATR/CHK1 axis with PARP inhibition results in tumor regression in BRCA mutant ovarian cancer models.
Targeting the BRCA1/2 tumor suppressors.
Targeting the DNA Damage Response in Cancer.
Targeting the DNA damage response in oncology: past, present and future perspectives.
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.
Targeting triple negative breast cancer: Is p53 the answer?
Targets for Therapy of Bladder Cancer.
Taurolidine: cytotoxic and mechanistic evaluation of a novel antineoplastic agent.
TCDD-inducible poly(ADP-ribose) polymerase: a novel response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP), A Novel Therapeutic Target Of Breast Cancer.
TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.
TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors.
Telomerase and poly(ADP-ribose) polymerase-1 activity sensing based on the high fluorescence selectivity and sensitivity of TOTO-1 towards G bases in single-stranded DNA and poly(ADP-ribose).
Telomere instability in papillary bladder urothelial carcinomas: Comparison with grading and risk of recurrence.
Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.
Tephrosin induces apoptosis of human pancreatic cancer cells through the generation of reactive oxygen species.
Tephrosin-induced autophagic cell death in A549 non-small cell lung cancer cells.
TERT regulates cell survival independent of telomerase enzymatic activity.
TGF? induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes.
TGF?R-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment.
The ?-NAD
The Anti-Proliferative Activity of the Hybrid TMS-TMF-4f Compound Against Human Cervical Cancer Involves Apoptosis Mediated by STAT3 Inactivation.
The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication.
The ATM-Chk2 and ATR-Chk1 Pathways in DNA Damage Signaling and Cancer.
The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity.
The BET inhibitor JQ1 attenuates double-strand break repair and sensitizes models of pancreatic ductal adenocarcinoma to PARP inhibitors.
The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.
The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting.
The cancer-testis gene, MEIOB, sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency.
The CDK1 inhibitor RO3306 improves the response of BRCA-pro?cient breast cancer cells to PARP inhibition.
The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment.
The clinical development of inhibitors of poly(ADP-ribose) polymerase.
The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer.
The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice.
The clinically used PARP inhibitor olaparib improves organ function, suppresses inflammatory responses and accelerates wound healing in a murine model of third-degree burn injury.
The combination of A-966492 and Topotecan for effective radiosensitization on glioblastoma spheroids.
The combination of BET and PARP inhibitors is synergistic in models of cholangiocarcinoma.
The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer.
The combination of the PARP inhibitor rucaparib and 5FU is an effective strategy for treating acute leukemias.
The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis.
The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer.
The critical role of autophagy in cadmium-induced immunosuppression regulated by endoplasmic reticulum stress-mediated calpain activation in RAW264.7 mouse monocytes.
The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.
The current landscape of molecular profiling in the treatment of epithelial ovarian cancer.
The current status of PARP inhibitors in ovarian cancer.
The Cytotoxic and Apoptotic Effects of the Brown Algae Colpomenia sinuosa are Mediated by the Generation of Reactive Oxygen Species.
The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors.
The development of PARP as a successful target for cancer therapy.
The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art.
The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.
The DNA damaging revolution.
The DNA Damaging Revolution: PARP Inhibitors and Beyond.
The early immunological response to acute ischemic stroke: Differential gene expression in subpopulations of mononuclear cells.
The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3'Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort.
The effect of the nitroxide pirolin on oxidative stress induced by doxorubicin and taxanes in the rat brain.
The Effects of Chemotherapeutics on the Ovarian Cancer Microenvironment.
The efficacy and adverse effects of PARP inhibitor combined with chemotherapy compared with chemotherapy alone in the treatment of cancer patient: A protocol for systematic review.
The efficacy and safety of olaparib in the treatment of cancers: a meta-analysis of randomized controlled trials.
The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells.
The emerging potential of poly(ADP-ribose) polymerase inhibitors in the treatment of breast cancer.
The emerging role of homologous recombination repair and PARP inhibitors in genitourinary malignancies.
The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer.
The Emerging Role of Poly(ADP-Ribose) Polymerase Inhibitors in Cancer Treatment.
The evolving landscape of predictive biomarkers of response to PARP inhibitors.
The evolving management of metastatic triple negative breast cancer.
The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity.
The exposure of carcinogen-initiated primary neonatal rat hepatocytes to tumor promoters modulates both the transcripts and the enzymatic activity of nuclear poly(ADP-ribose) polymerase.
The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome.
The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly(ADP-ribosyl)ation Activity in Cancer Cells.
The HSF1-PARP13-PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis.
The human papillomavirus type 16 E5 protein impairs TRAIL- and FasL-mediated apoptosis in HaCaT cells by different mechanisms.
The implications of BRCA loss of heterozygosity (LOH) and deficient mismatch repair gene (dMMR) expression in the breast cancer of a patient with both inherited breast and ovarian cancer syndrome (BRCA2) and Lynch syndrome (MLH1).
The Importance of Distinguishing Sporadic Cancers from Those Related to Cancer Predisposing Germline Mutations.
The Indenoisoquinoline TOP1 Inhibitors Selectively Target Homologous Recombination-Deficient and Schlafen 11-Positive Cancer Cells and Synergize with Olaparib.
The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors.
The Inhibitory Effects of HYDAMTIQ, a Novel PARP Inhibitor, on Growth in Human Tumor Cell Lines With Defective DNA Damage Response Pathways.
The Interplay Between the DNA Damage Response, RNA Processing and Extracellular Vesicles.
The key residues of active sites on the catalytic fragment for Paclitaxel interacting with poly (adp-ribose) polymerase.
The kinase polypharmacology landscape of clinical PARP inhibitors.
The Landscape and Therapeutic Implications of Molecular Profiles in Epithelial Ovarian Cancer.
The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.
The mechanism of cancer cell death by PARP inhibitors goes beyond DNA damage alone.
The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models.
The methanol-ethyl acetate partitioned fraction from Chinese olive fruits inhibits cancer cell proliferation and tumor growth by promoting apoptosis through the suppression of the NF-?B signaling pathway.
The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells.
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling.
The Multifactorial Role of PARP-1 in Tumor Microenvironment.
The new-generation proteasome inhibitor oprozomib increases the sensitivity of cervical cancer cells to cisplatin-induced apoptosis.
The novel mechanism of anticancer effect on gastric cancer through inducing G0/G1 cell cycle arrest and caspase-dependent apoptosis in vitro and in vivo by methionine enkephalin.
The NQO1 bioactivatable drug, ?-Lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.
The Nucleolus and PARP1 in Cancer Biology.
The p.Ser64Leu and p.Pro104Leu missense variants of PALB2 identified in familial pancreatic cancer patients compromise the DNA damage response.
The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks.
The PARP Enzyme Family and the Hallmarks of Cancer Part 2: Hallmarks Related to Cancer Host Interactions.
The PARP inhibitor ABT-888 synergizes irinotecan treatment of colon cancer cell lines.
The PARP inhibitor AZD2461 provides insights into the role of PARP3 inhibition for both synthetic lethality and tolerability with chemotherapy in preclinical models.
The PARP inhibitor olaparib induces significant killing of ATM deficient lymphoid tumour cells in vitro and in vivo.
The PARP inhibitor PJ-34 sensitizes cells to UVA-induced phototoxicity by a PARP independent mechanism.
The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation.
The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice.
The PARP Way to Epigenetic Changes.
The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1(-/-) murine model of ovarian cancer.
The Phytosterol Peniocerol Inhibits Cell Proliferation and Tumor Growth in a Colon Cancer Xenograft Model.
The Poly (ADP-Ribose) Polymerase Inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells.
The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the ?-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2.
The poly(ADP-Ribose) polymerase inhibitor ABT-888 reduces radiation-induced nuclear EGFR and augments head and neck tumor response to radiotherapy.
The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial.
The poly(ADP-ribose) polymerase inhibitor olaparib induces up-regulation of death receptors in primary acute myeloid leukemia blasts by NF-?B activation.
The poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide suppresses cell growth and migration, enhancing suppressive effects of cisplatin in osteosarcoma cells.
The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy.
The potential of PARP inhibitors in genetic breast and ovarian cancers.
The potential of PARP inhibitors in neuro-oncology.
The potential role and application of PARP inhibitors in cancer treatment.
The potentiation of the antitumor activity but not toxicity of bleomycin by 3-aminobenzamide.
The Prognostic Value of BRCA1 and PARP Expression in Epithelial Ovarian Carcinoma: Immunohistochemical Detection.
The Prognostic Values of PARP-1 Expression in Uveal Melanoma.
The promise and current status of CDK12/13 inhibition for the treatment of cancer.
The promise of combining inhibition of PI3K and PARP as cancer therapy.
The Promise of Proteomics for the Study of ADP-Ribosylation.
The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin.
The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy.
The role of homologous recombination deficiency testing in ovarian cancer and its clinical implications: do we need it?
The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy.
The role of nitric oxide in cancer.
The role of PARP in DNA repair and its therapeutic exploitation.
The role of PARP inhibitors in BRCA mutated pancreatic cancer.
The Role of PARP Inhibitors in the Treatment of Gynecologic Malignancies.
The Role of PARP Inhibitors in the Treatment of Prostate Cancer: Recent Advances in Clinical Trials.
The Role of PARP-1 in Host-Pathogen Interaction and Cellular Stress Responses.
The role of PARP1 in the DNA damage response and its application in tumor therapy.
The role of poly adenosine diphosphate ribose polymerase inhibitors in breast and ovarian cancer: current status and future directions.
The role of poly(ADP-ribose) polymerase inhibitors in the treatment of cancer and methods to overcome resistance: a review.
The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis.
The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy.
The role of thiamine in cancer: possible genetic and cellular signaling mechanisms.
The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks.
The shieldin complex mediates 53BP1-dependent DNA repair.
The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm.
The spectrum of tumors harboring BAP1 gene alterations.
The status of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in ovarian cancer, part 1: olaparib.
The status of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in ovarian cancer, part 2: extending the scope beyond olaparib and BRCA1/2 mutations.
The Synergistic Effect of PARP Inhibitors and Immune Checkpoint Inhibitors.
The synergistic proapoptotic effect of PARP-1 and HDAC inhibition in cutaneous T-cell lymphoma is mediated via Blimp-1.
The telomeric PARP, tankyrases, as targets for cancer therapy.
The therapeutic ratio is preserved for radiotherapy or cisplatin treatment in BRCA2-mutated prostate cancers.
The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells.
The Treatment of Heterotopic Human Colon Xenograft Tumors in Mice with 5-Fluorouracil Attached to Magnetic Nanoparticles in Combination with Magnetic Hyperthermia Is More Efficient than Either Therapy Alone.
The triple-negative subtype: new ideas for the poorest prognosis breast cancer.
The tumor metabolome.
The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency.
The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings.
The ups and downs of DNA repair biomarkers for PARP inhibitor therapies.
The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy-Current progress and future direction.
The use of olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks.
The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy, Use as a Single Agent in Susceptible Patients, and Techniques Used to Identify Susceptible Patients.
The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy; Use as a Single Agent in Susceptible Patients; Techniques Used to Identify Susceptible Patients.
The vitamin nicotinamide: translating nutrition into clinical care.
Theoretical insights into molecular mechanism and energy criteria of PARP-2 enzyme inhibition by benzimidazole analogues.
Therapeutic Application of PARP Inhibitors in Neuro-Oncology.
Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond.
Therapeutic Approaches for Women Predisposed to Breast Cancer.
Therapeutic considerations of PARP in stem cell biology: Relevance in cancer and beyond.
Therapeutic Implications of Germline Testing in Patients With Advanced Cancers.
Therapeutic Potential of Combining PARP Inhibitor and Immunotherapy in Solid Tumors.
Therapeutic potential of investigational CHK-1 inhibitors for the treatment of solid tumors.
Therapeutic potential of PARP inhibitors for metastatic breast cancer.
Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers.
Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer.
Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2.
Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy.
Therapeutic strategies for triple-negative breast cancer.
Therapeutic targeting and patient selection for cancers with homologous recombination defects.
Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver.
Therapeutic Targeting of MZF1-AS1/PARP1/E2F1 Axis Inhibits Proline Synthesis and Neuroblastoma Progression.
Therapeutic Targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities.
Therapy of Smac mimetic SM-164 in combination with gemcitabine for pancreatic cancer.
Therapy-related myeloid neoplasms following treatment with PARP inhibitors: new molecular insights.
Thermal proteome profiling identifies oxidative-dependent inhibition of the transcription of major oncogenes as a new therapeutic mechanism for select anticancer compounds.
Thorough in silico and in vitro cDNA analysis of 21 putative BRCA1 and BRCA2 splice variants and a complex tandem duplication in BRCA2 allowing the identification of activated cryptic splice donor sites in BRCA2 exon 11.
Three apoptotic genes are upregulated in a patient with Alzheimer's disease and well-differentiated squamous cell carcinoma.
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Three-component Castagnoli-Cushman reaction with ammonium acetate delivers 2-unsubstituted isoquinol-1-ones as potent inhibitors of poly(ADP-ribose) polymerase (PARP).
Three-dimensional oxabicycloheptene sulfonate targets the homologous recombination and repair programmes through estrogen receptor ? antagonism.
Thymoquinone enhances cisplatin-response through direct tumor effects in a syngeneic mouse model of ovarian cancer.
TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy.
Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo.
TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death.
Top1-PARP1 association and beyond: from DNA topology to break repair.
Total Synthesis and Biological Evaluation of Grassypeptolide?A.
Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors.
Toward specific functions of poly(ADP-ribose) polymerase-2.
Towards small molecule inhibitors of mono-ADP-ribosyltransferases.
Tranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancer.
Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy.
Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target?
Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1.
Transcriptional profiling of genes at the human common fragile site FRA1H in tumor-derived cell lines.
Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer.
Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription.
Transcriptional roles of PARP1 in cancer.
Transcriptomic heterogeneity of androgen receptor (AR) activity defines a de novo low AR-active subclass in treatment naïve primary prostate cancer.
Transferrin-Conjugated Erianin-Loaded Liposomes Suppress the Growth of Liver Cancer by Modulating Oxidative Stress.
Transferrin-conjugated liposomes loaded with carnosic acid inhibit liver cancer growth by inducing mitochondria-mediated apoptosis.
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.
Trapping PARP.
Trastuzumab resistant HER2+ breast cancer cells retain sensitivity to poly (ADP-ribose) polymerase (PARP) inhibition.
Treatment landscape of metastatic pancreatic cancer.
Treatment of Pediatric Glioblastoma with Combination Olaparib and Temozolomide Demonstrates 2-Year Durable Response.
Treatment with insulin inhibits poly(ADP-ribose)polymerase activation in a rat model of endotoxemia.
Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer.
Trial watch - inhibiting PARP enzymes for anticancer therapy.
Trichodermin induces cell apoptosis through mitochondrial dysfunction and endoplasmic reticulum stress in human chondrosarcoma cells.
Trichosanthin inhibits breast cancer cell proliferation in both cell lines and nude mice by promotion of apoptosis.
Trichothecin induces cell death in NF-?B constitutively activated human cancer cells via inhibition of IKK? phosphorylation.
Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells.
TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins.
TRIP13 regulates DNA repair pathway choice through REV7 conformational change.
Triple-negative breast cancer and Poly(ADP-ribose) polymerase inhibitors.
Triple-negative breast cancer: are we making headway at least?
Triple-negative breast cancer: disease entity or title of convenience?
Triple-negative breast cancer: molecular features, pathogenesis, treatment and current lines of research.
Trolox enhances curcumin's cytotoxicity through induction of oxidative stress.
Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1.
Tryptophanyl-tRNA Synthetase Sensitizes Hormone Receptor-Positive Breast Cancer to Docetaxel-Based Chemotherapy.
TSL-1502, a glucuronide prodrug of a poly (ADP-ribose) polymerase (PARP) inhibitor, exhibits potent anti-tumor activity in preclinical models.
Tumor BRCA Test for Patients with Epithelial Ovarian Cancer: The Role of Molecular Pathology in the Era of PARP Inhibitor Therapy.
Tumor burden is a potential marker of PARP inhibitor effects in ovarian cancer: a head-to-head observational series.
Tumor Cell Recovery from Senescence Induced by Radiation with PARP Inhibition.
Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts.
Tumor necrosis factor alpha 'primes' the platelet-activating factor-induced superoxide production by human neutrophils: possible involvement of G proteins.
Tumor necrosis factor-alpha induces apoptosis associated with poly(ADP-ribose) polymerase cleavage in HT-29 colon cancer cells.
Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death.
Tumor regression mechanisms by IL-13 receptor-targeted cancer therapy involve apoptotic pathways.
Tumor Suppression by PARP Inhibitors Is Potentiated by c-MET Inhibition.
Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications.
Tumor treating fields combined with a poly (adenosine diphosphate-ribose) polymerase inhibitor during radiotherapy for rapidly progressing IDH-wildtype diffuse astrocytoma: a case report.
Tumor-induced apoptosis of T lymphocytes: elucidation of intracellular apoptotic events.
Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity.
Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro.
Tumor-targeted Nanoparticle Delivery of HuR siRNA Inhibits Lung Tumor Growth In Vitro and In Vivo By Disrupting the Oncogenic Activity of the RNA-binding Protein HuR.
Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors.
Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules.
Tumour lineage shapes BRCA-mediated phenotypes.
Two decades beyond BRCA1/2: Homologous recombination, hereditary cancer risk and a target for ovarian cancer therapy.
Two DNA repair gene polymorphisms on the risk of gastrointestinal cancers: a meta-analysis.
Two experts and a newbie: [18F]PARPi vs [18F]FTT vs [18F]FPyPARP-a comparison of PARP imaging agents.
Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors.
Tyrosyl-DNA phosphodiesterase 1 (TDP1) and Poly (ADP-Ribose) Polymerase-1 (PARP1) deficiency are cytotoxic to rhabdomyosarcoma cells.
UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors.
Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.
Uncovering synthetic lethal interactions for therapeutic targets and predictive markers in lung adenocarcinoma.
Understanding and addressing barriers to successful adenovirus-based virotherapy for ovarian cancer.
Understanding and overcoming resistance to PARP inhibitors in cancer therapy.
Understanding Resistance Mechanisms and Expanding the Therapeutic Utility of PARP Inhibitors.
Understanding specific functions of PARP-2: new lessons for cancer therapy.
Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib.
Understanding the DNA double-strand break repair and its therapeutic implications.
Understanding the mechanism of amygdalin's multifunctional anti-cancer action using computational approach.
Universal tumor DNA BRCA1/2 testing of ovarian cancer: prescreening PARPi treatment and genetic predisposition.
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.
Unsymmetric Cisplatin-Based Pt(IV) Conjugates Containing a PARP-1 Inhibitor Pharmacophore Tested on Malignant Pleural Mesothelioma Cell Lines.
Unusual metastasis in BRCA mutated pancreatic cancer while on maintenance Olaparib: Two case reports and review of the literature.
Unveiling the mechanistic roles of chlorine substituted phthalazinone-based compounds containing chlorophenyl moiety towards the differential inhibition of poly (ADP-ribose) polymerase-1 in the treatment of lung cancer.
Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas.
Update on PARP1 inhibitors in ovarian cancer.
Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment.
Update on the Role of Poly (ADP-Ribose) Polymerase Inhibitors in the DNA Repair-Deficient Pancreatic Cancers: A Narrative Review.
Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types.
Use of Inosine Monophosphate Dehydrogenase Activity Assay to Determine the Specificity of PARP-1 Inhibitors.
Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic.
Using Clickable NAD(+) Analogs to Label Substrate Proteins of PARPs.
Using next-generation sequencing to redefine BRCAness in triple-negative breast cancer.
Using PARP Inhibitors in Advanced Ovarian Cancer.
USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors.
Utility of Homologous Recombination Deficiency Biomarkers Across Cancer Types.
Utilizing an interim futility analysis of the OVAL study (VB-111-701/GOG 3018) for potential reduction of risk: A phase III, double blind, randomized controlled trial of ofranergene obadenovec (VB-111) and weekly paclitaxel in patients with platinum resistant ovarian cancer.
Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers.
Valproate augments Niraparib killing of tumor cells.
Variations in the mRNA expression of poly(ADP-ribose) polymerases, poly(ADP-ribose) glycohydrolase and ADP-ribosylhydrolase 3 in breast tumors and impact on clinical outcome.
Vasoactivity of Rucaparib, a PARP-1 Inhibitor, is a Complex Process that Involves Myosin Light Chain Kinase, P2 Receptors, and PARP Itself.
VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth.
Veliparib Alone or in Combination with Mitomycin C in Patients with Solid Tumors With Functional Deficiency in Homologous Recombination Repair.
Veliparib for the treatment of ovarian cancer.
Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma.
Veliparib in ovarian cancer: a new synthetically lethal therapeutic approach.
Veliparib Monotherapy to Patients With BRCA Germ Line Mutation and Platinum-Resistant or Partially Platinum-Sensitive Relapse of Epithelial Ovarian Cancer: A Phase I/II Study.
Veliparib with carboplatin and paclitaxel in BRCA-mutated advanced breast cancer (BROCADE3): a randomised, double-blind, placebo-controlled, phase 3 trial.
Veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in patients with BRCA1/2 locally recurrent/metastatic breast cancer: randomized phase II study.
Verapamil enhances the sensitivity of oxaliplatin to tumor cells by influencing the PARP pathway.
Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation.
Verteporfin inhibits cell proliferation and induces apoptosis in different subtypes of breast cancer cell lines without light activation.
Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis, Exerting Antitumor Efficacy.
Virtual screening of small molecules databases for discovery of novel PARP-1 inhibitors: combination of in silico and in vitro studies.
Vitamin C and Cell Death.
Vitamin E ?-Tocotrienol Prolongs Survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) Transgenic Mouse Model of Pancreatic Cancer.
VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases.
Voies de réparation de l'ADN et cancers bronchiques non à petites cellules : perspectives cliniques.
vPARP Adjusts MVP Expression in Drug-resistant Cell Lines in Conjunction with MDR Proteins.
When and How to Use PARP Inhibitors in Prostate Cancer: A Systematic Review of the Literature with an Update on On-Going Trials.
Whence High-Grade Serous Ovarian Cancer.
Whole-body hyperthermia and ADPRT inhibition in experimental treatment of brain tumors.
Wikstromol from Wikstroemia indica induces apoptosis and suppresses migration of MDA-MB-231 cells via inhibiting PI3K/Akt pathway.
WNT inhibition creates a BRCA-like state in Wnt-addicted cancer.
Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors.
Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion.
Wnt/?-catenin signaling as a useful therapeutic target in hepatoblastoma.
WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
X-ray-induced damage repair in exponentially growing and growth arrested confluent poly(adenosine diphosphate-ribose) polymerase-deficient V79 chinese hamster cell line.
Xenografts of primary human gynecological tumors grown under the renal capsule of NOD/SCID mice show genetic stability during serial transplantation and respond to cytotoxic chemotherapy.
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells.
XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition.
YQWY Decoction Improves Myocardial Remodeling via Activating the IL-10/Stat3 Signaling Pathway.
Zebrafish as an in vivo screening tool to establish PARP inhibitor efficacy.
[(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer.
[18F]PARPi Imaging Is Not Affected by HPV Status In Vitro.
[Analysis of PARP inhibitors induced anemia in advanced and relapsed epithelial ovarian cancer].
[Apoptosis mechanism of taxol combined with resveratrol on human laryngeal carcinoma Hep-2 cells].
[Aspirin inhibits the proliferation of breast cancer cells via inducing apoptosis and autophagy].
[BRCA diagnostics of ovarian cancer : Molecular tumor testing since the introduction of PARP inhibitor therapy].
[BRCA mutations: from Angelina Jolie to specific therapies].
[BRCA1 and BRCA2 - pathologists starting kit].
[Breakthrough breast cancer treatment--PARP inhibitor, BRCA, and triple negative breast cancer]
[c-MYC, PARP1 and BIN1 as targets for therapy of cancer cell resistance].
[Cancer therapy by PARP inhibitors].
[Clinical development of PARP inhibitors].
[Cytotoxicity of beta-lapachone, an naphthoquinone with possible therapeutic use]
[Enhancement of bleomycin or hyperthermia induced tumor cell damage by ADPRT inhibitor]
[Fermented wheat germ extract in the supportive therapy of colorectal cancer]
[From poly(ADP-ribose) discovery to PARP inhibitors in cancer therapy].
[Hereditary Breast and Ovarian Cancer Syndrome].
[Hereditary breast cancer]
[Hereditary breast carcinomas pathologist's perspective].
[Homologous recombination repair deficiency as a predictive biomarker : Basic mechanisms and detection methods].
[Identification of basal-like carcinomas in clinical practice: "triple zero/BRCA1-like" carcinomas]
[Knock-down of DAB2 interacting protein (DAB2IP) promotes proliferation and inhibits apoptosis of bladder cancer cells].
[Learning from My Experience: Outpatient Care for Cancer Multigene Genomic Testing].
[Medical treatment options in BRCA-associated cancers].
[Molecular basis of breast cancer related to BRCA 1 and BRCA2 genes: characteristics and targeting therapy]
[Molecular characterisation defines several subtypes of pancreatic ductal adenocarcinoma].
[Molecular Mechanisms of Carcinogenesis of Epithelial Ovarian Cancers].
[Molecular Targeted Therapies for Hereditary Cancer Syndrome].
[Molecular tumor board prostate cancer].
[New therapeutic strategies in advanced stage breast and tubo-ovarian cancers].
[Olaparib potentiates the antitumor effect of Taxol on 4T1 breast cancer].
[PARP inhibitors and breast cancer: update and perspectives].
[PARP inhibitors and radiotherapy: rational and prospects for a clinical use].
[PARP inhibitors for cancer therapy].
[PARP inhibitors--theoretical basis and clinical application].
[PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study].
[Poly(ADP-ribose) polymerase (PARP) inhibitors in BRCA1/2 cancer therapy].
[Poly(ADP-ribose) polymerase (PARP): physiological and pathological roles].
[Recent therapeutic trends in triple-negative metastatic breast cancers: PARP inhibitors, immunotherapies and antibody-drug conjugates].
[Research progresses of the PARP inhibitors for the treatment of cancer].
[Role of proteins in Fas-mediated apoptosis in tumor cells and lymphocytes co-cultured in vitro]
[Specific features of drug sensitivity of hereditary cancers].
[Synthesis and activity evaluation of PARP-1 inhibitors with azaindole skeleton].
[Testing of mutations in BRCA1 and BRCA2 genes in tumor tissues - possibilities and limitations].
[The Antitumor Effects of Fisetin on Ovarian Cancer in vitro and in vivo.]
[The clonal evolution of osteosarcomas].
[The future of breast cancer radiotherapy: From one size fits all to taylor-made treatment.]
[The long coding RNA GSTM3TV2 acts an oncogene to promote chemoresistance in pancreatic cancer].
[The Role of Preoperative Chemotherapy Depending on Breast Cancer Subtype].
{beta}2-Microglobulin Is a Signaling and Growth-Promoting Factor for Human Prostate Cancer Bone Metastasis.
Neoplasms, Germ Cell and Embryonal
Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines.
Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP expression in germ cell tumours.
Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment.
Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease.
Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors.
Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition.
Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review.
Neoplastic Cells, Circulating
A Phase I Study of Veliparib in Combination with Metronomic Cyclophosphamide in Adults with Refractory Solid Tumors and Lymphomas.
Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer.
Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer.
Sequences and combinations of multifaceted therapy in advanced prostate cancer.
The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer.
Neoplastic Syndromes, Hereditary
[Molecular Targeted Therapies for Hereditary Cancer Syndrome].
Nephritis
Differential regulation of cell death programs in males and females by Poly (ADP-Ribose) Polymerase-1 and 17? estradiol.
Poly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus.
Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation.
Nervous System Autoimmune Disease, Experimental
Interleukin-37 (IL-37) Suppresses Pertussis Toxin-Induced Inflammatory Myopathy in a Rat Model.
Nervous System Diseases
PARP inhibition attenuates early brain injury through NF-?B/MMP-9 pathway in a rat model of subarachnoid hemorrhage.
PARP overactivation in neurological disorders.
Poly ADP-ribose polymerase-1: an international molecule of mystery.
Potential role of poly (ADP-ribose) polymerase in delayed cerebral vasospasm following subarachnoid hemorrhage in rats.
Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species.
Neuralgia
Animal models of diabetic neuropathic pain.
Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome.
Intrathecal pertussis toxin induces thermal hyperalgesia: involvement of excitatory and inhibitory amino acids.
PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy.
PARP-1-regulated TNF-? expression in the dorsal root ganglia and spinal dorsal horn contributes to the pathogenesis of neuropathic pain in rats.
Poly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: a commentary on "PARP Inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy".
Poly(ADP-ribose) polymerase inhibition reveals a potential mechanism to promote neuroprotection and treat neuropathic pain.
Some new insights into the effects of opioids in phasic and tonic nociceptive tests.
Neuritis
Experimental allergic neuritis in the SJL/J mouse: induction of severe and reproducible disease with bovine peripheral nerve myelin and pertussis toxin with or without interleukin-12.
Myelin Protein Zero180-199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice.
P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice.
Neuritis, Autoimmune, Experimental
Experimental allergic neuritis in the SJL/J mouse: induction of severe and reproducible disease with bovine peripheral nerve myelin and pertussis toxin with or without interleukin-12.
Myelin Protein Zero180-199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice.
P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice.
Neuroblastoma
A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors.
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma.
Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation.
An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma.
Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases.
Association of PARP1 polymorphisms with response to chemotherapy in patients with high-risk neuroblastoma.
ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms.
Biological Effects of MC2050, a Quinazoline-Based PARP-1 Inhibitor, in Human Neuroblastoma and EBV-Positive Burkitt's Lymphoma Cells.
Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C.
Characterization of a neutralizing monoclonal antibody against botulinum ADP-ribosyltransferase, C3 exoenzyme.
Characterization of Chikungunya virus infection in human neuroblastoma SH-SY5Y cells: role of apoptosis in neuronal cell death.
Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells.
Chrysanthemum morifolium Ramat (CM) extract protects human neuroblastoma SH-SY5Y cells against MPP(+)-induced cytotoxicity.
Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma.
Coupling of human D-1 dopamine receptors to different guanine nucleotide binding proteins. Evidence that D-1 dopamine receptors can couple to both Gs and G(o).
Coupling of the human Y2 receptor for neuropeptide Y and peptide YY to guanine nucleotide inhibitory proteins in permeabilized SMS-KAN cells.
Cr(VI) induces ROS-mediated mitochondrial-dependent apoptosis in neuronal cells via the activation of Akt/ERK/AMPK signaling pathway.
CRISPR/Cas9 nickase mediated targeting of urokinase receptor gene inhibits neuroblastoma cell proliferation.
Cytoprotective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells.
Deletion of 11q in neuroblastomas drives sensitivity to PARP inhibition.
Differential radiosensitization by the poly(ADP-ribose) transferase inhibitor 3-aminobenzamide in human tumor cells of varying radiosensitivity.
Effect of chronic D-Ala,2 D-Leu5-enkephalin or pertussis toxin treatment on the high-affinity state of delta opioid receptor in neuroblastoma x glioma NG108-15 hybrid cells.
Effect of pertussis toxin treatment on the down-regulation of opiate receptors in neuroblastoma X glioma NG108-15 hybrid cells.
Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells.
Expression of Prenylated Rab Acceptor 1 Domain Family, Member 2 (PRAF2) in Neuroblastoma: Correlation with Clinical Features, Cellular Localization, and Cerulenin-Mediated Apoptosis Regulation.
Functional trans-inactivation of insulin receptor kinase by growth-inhibitory angiotensin II AT2 receptor.
Generation of reactive oxygen species mediates butein-induced apoptosis in neuroblastoma cells.
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.
High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma.
Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells.
Identification of a guanine nucleotide-binding protein G(o) in human neuroblastoma.
Inhibition of gamma ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblastoma cells.
Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.
Inversion of Ca2+ current modulation during recovery of neuroblastoma cells from pertussis toxin pretreatment.
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe.
Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.
Low levels of selenium compounds are selectively toxic for a human neuron cell line through ROS/RNS increase and apoptotic process activation.
mda-7/IL-24 Induces Cell Death in Neuroblastoma through a Novel Mechanism Involving AIF and ATM.
Morphological effects, rate of incorporation, and the enzymatic action of botulinum ADP-ribosyltransferase, known as C3 exoenzyme, on human neuroblastoma GOTO cells.
Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin.
Muscarinic receptor-mediated hydrolysis of phosphatidylinositols in human neuroblastoma (SH-SY5Y) cells is sensitive to pertussis toxin.
MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma.
Neural differentiation of human neuroblastoma GOTO cells via a Rho-Rho kinase-phosphorylation signal transduction and continuous observation of a single GOTO cell during differentiation.
Neurotensin, bradykinin and somatostatin inhibit cAMP production in neuroblastoma N1E115 cells via both pertussis toxin sensitive and insensitive mechanisms.
Neurotensin-mediated inhibition of cyclic AMP formation in neuroblastoma N1E115 cells: involvement of the inhibitory GTP-binding component of adenylate cyclase.
Oncolytic adenovirus-mediated short hairpin RNA targeting MYCN gene induces apoptosis by upregulating RKIP in neuroblastoma.
Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (Gi) in membranes of neuroblastoma x glioma hybrid cells.
PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma.
PARP Targeted Alpha-Particle Therapy Enhances Response to PD-1 Immune-Checkpoint Blockade in a Syngeneic Mouse Model of Glioblastoma.
PARP-1 Modulates Amyloid Beta Peptide-Induced Neuronal Damage.
PARP-1-targeted Auger emitters display high-LET cytotoxic properties in vitro but show limited therapeutic utility in solid tumor models of human neuroblastoma.
PARP1 gene polymorphisms and neuroblastoma susceptibility in Chinese children.
Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: role of poly (ADP-ribose) polymerase.
Pertussis toxin decreases opiate receptor binding and adenylate inhibition in a neuroblastoma x glioma hybrid cell line.
Pertussis toxin inhibits alpha 2-adrenoceptor-mediated inhibition of adenylate cyclase without affecting muscarinic regulation of [Ca2+]i or inositol phosphate generation in SH-SY5Y human neuroblastoma cells.
PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4.
Poly (ADP-ribose) polymerase induction is an early signal of apoptosis in human neuroblastoma.
Poly (ADP-Ribose) Polymerase Inhibitor MK-4827 together with Radiation as a Novel Therapy for Metastatic Neuroblastoma.
Poly(ADP-ribose) polymerase-1 is a nuclear epigenetic regulator of mitochondrial DNA repair and transcription.
Possible involvement of ADP-ribosylation of particular enzymes in cell death induced by nitric oxide-donors in human neuroblastoma cells.
Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells.
Pyrido[2',1':2,3]imidazo[4,5-c]isoquinolin-5-amines as Potential Cytotoxic Agents against Human Neuroblastoma.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Rapid activation of poly(ADP-ribose) polymerase contributes to Sindbis virus and staurosporine-induced apoptotic cell death.
Role of a protein regulating guanine nucleotide binding in phosphoinositide breakdown and calcium mobilization by bradykinin in neuroblastoma X glioma hybrid NG108-15 cells: effects of pertussis toxin and cholera toxin on receptor-mediated signal transduction.
Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition.
Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.
Suppressive effect of PARP-1 inhibitor on JC virus replication in vitro.
Synergism in cytosolic Ca2+ mobilization between bradykinin and agonists for pertussis toxin-sensitive G-protein-coupled receptors in NG 108-15 cells.
Synergistic induction of apoptosis in neuroblastoma cells using a combination of cytostatic drugs with interferon-gamma and TRAIL.
Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models.
Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells.
The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No.
The novel anti-neuroblastoma agent PF403, inhibits proliferation and invasion in vitro and in brain xenografts.
The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study.
The toxicity of nitrofuran compounds on melanoma and neuroblastoma cells is enhanced by Olaparib and ameliorated by melanin pigment.
[Inhibition of tissue factor by siRNA enhances doxorubicin-induced apoptosis in human neuroblastoma]
Neurodegenerative Diseases
A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice.
A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia.
Cell Death Mechanisms of Neurodegeneration.
Ceramide in the Molecular Mechanisms of Neuronal Cell Death. The Role of Sphingosine-1-Phosphate.
Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors.
Development of a miniaturized assay for the high-throughput screening program for poly(ADP-ribose) polymerase-1.
Drug repurposing studies of PARP inhibitors as a new therapy for inherited retinal degeneration.
Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke.
Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement.
Extracellular poly(ADP-ribose) is a neurotrophic signal that upregulates glial cell line-derived neurotrophic factor (GDNF) levels in vitro and in vivo.
Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA.
Identification and mechanism of action analysis of the new PARP-1 inhibitor 2?-hydroxygenkwanol A.
Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders.
mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors.
Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases.
Natural Inhibitors of Poly(ADP-ribose) Polymerase-1.
Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation.
Nicotinamide Inhibits Ethanol-Induced Caspase-3 and PARP-1 Over-activation and Subsequent Neurodegeneration in the Developing Mouse Cerebellum.
Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease.
Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy.
PARkinson's: From cellular mechanisms to potential therapeutics.
PARP activity and inhibition in fetal and adult oligodendrocyte precursor cells: Effect on cell survival and differentiation.
PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons.
PARP-1 involvement in neurodegeneration: A focus on Alzheimer's and Parkinson's diseases.
PARP-DNA trapping ability of PARP inhibitors jeopardizes astrocyte viability: Implications for CNS disease therapeutics.
PARP10 deficiency manifests by severe developmental delay and DNA repair defect.
PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders.
Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases.
Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications.
Poly(ADP-ribose) polymerase is found in both the nucleus and cytoplasm of human CNS neurons.
Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders.
Poly(ADP-ribose) polymerase-1 protects neurons against apoptosis induced by oxidative stress.
Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications.
Poly(ADP-ribose) signal in seizures-induced neuron death.
Poly(ADP-ribosylated) proteins in ?-amyloid peptide-stimulated microglial cells.
Poly(ADP-Ribosylation) in Age-Related Neurological Disease.
Post-transcriptional regulation by poly(ADP-ribosyl)ation of the RNA-binding proteins.
Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors.
Protection Against Chronic Hypoperfusion-Induced Retinal Neurodegeneration by PARP Inhibition via Activation of PI-3-kinase Akt Pathway and Suppression of JNK and p38 MAP Kinases.
Synthesis and evaluation of an AZD2461 [18F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant.
The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease.
The impact of the phytotherapeutic agent quercetin on expression of genes and activity of signaling pathways.
The PARP inhibitor benzamide protects against kainate and NMDA but not AMPA lesioning of the mouse striatum in vivo.
The Promise of Proteomics for the Study of ADP-Ribosylation.
The role of PARP1 in neurodegenerative diseases and aging.
[Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase]
[Poly adenosine diphosphate-ribosylation and neurodegenerative diseases].
Neuroectodermal Tumors, Primitive
Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors.
Neuroendocrine Tumors
Novel insights into the neuroendocrine control of inflammation: the role of GR and PARP1.
Potentiation of 177Lu-octreotate peptide receptor radionuclide therapy of human neuroendocrine tumor cells by PARP inhibitor.
The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors.
Neurofibrosarcoma
Poly (ADP) ribose polymerase inhibition: A potential treatment of malignant peripheral nerve sheath tumor.
Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas.
Neuroinflammatory Diseases
Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3? Signaling in LPS-Treated Adult Mice.
Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists.
Clinical perspectives of PARP inhibitors.
Combination strategy of PARP inhibitor with antioxidant prevent bioenergetic deficits and inflammatory changes in CCI-induced neuropathy.
Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration.
Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke.
Edaravone abrogates LPS-induced behavioral anomalies, neuroinflammation and PARP-1.
Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders.
Morin Mitigates Chronic Constriction Injury (CCI)-Induced Peripheral Neuropathy by Inhibiting Oxidative Stress Induced PARP Over-Activation and Neuroinflammation.
Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin.
Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in A?(1-42)-induced rat model of Alzheimer's disease.
Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease.
PARP inhibition attenuates neuroinflammation and oxidative stress in chronic constriction injury induced peripheral neuropathy.
PARP inhibition in vivo blocks alcohol-induced brain neurodegeneration and neuroinflammatory cytosolic phospholipase A2 elevations.
Poly (ADP-ribose) polymerase-1 inhibitor, 3-aminobenzamide pretreatment ameliorates lipopolysaccharide-induced neurobehavioral and neurochemical anomalies in mice.
Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis.
Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis.
Synthesis and evaluation of an AZD2461 [18F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant.
Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages.
Targeting Parthanatos in Ischemic Stroke.
Targeting poly(ADP-ribose) polymerase-1 as a promising approach for immunomodulation in multiple sclerosis?
The role of PARP1 in neurodegenerative diseases and aging.
Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE.
Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway.
Neuroma, Acoustic
DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.
Neutropenia
Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials.
Haematologic toxicities with PARP inhibitors in cancer patients: an up-to-date meta-analysis of 29 randomized controlled trials.
Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.
Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials.
Newcastle Disease
Biochemical Variations in Cytolytic Activity of Ortho- and Paramyxoviruses in Human Lung Tumor Cell Culture.
Nijmegen Breakage Syndrome
DNA Damage in Nijmegen Breakage Syndrome Cells Leads to PARP Hyperactivation and Increased Oxidative Stress.
Identification of proteins in the hamster DNA end-binding complex.
Non-alcoholic Fatty Liver Disease
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease.
Metabolic roles of poly(ADP-ribose) polymerases.
Mitigative effects of the bioactive flavonol fisetin on high-fat/high-sucrose induced nonalcoholic fatty liver disease in rats.
PARP1-mediated PPAR? poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease.
PARPs in lipid metabolism and related diseases.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
non-specific serine/threonine protein kinase deficiency
p53 Inhibits Adeno-Associated Viral Vector Integration.
Obesity
Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases.
Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage.
Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis.
Obesity alters phosphoramide mustard-induced ovarian DNA repair in mice.
PARP-1 DEFICIENCY EXACERBATES DIET-INDUCED OBESITY IN MICE.
PARP-1 Flips the Epigenetic Switch on Obesity.
PARPs in lipid metabolism and related diseases.
The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms.
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.
Oligospermia
Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia.
Optic Nerve Injuries
Increased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection.
Osteoarthritis
Involvement of poly(ADP-ribose) polymerase 1 in ERBB2 expression in rheumatoid synovial cells.
PARP-1 inhibition attenuates the inflammatory response in the cartilage of a rat model of osteoarthritis.
Osteoporosis
Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.
Osteosarcoma
Betulin inhibits mTOR and induces autophagy to promote apoptosis in human osteosarcoma cell lines.
Blocking HSP90 Addiction Inhibits Tumor Cell Proliferation, Metastasis Development, and Synergistically Acts with Zoledronic Acid to Delay Osteosarcoma Progression.
CCT128930 induces G1-phase arrest and apoptosis and synergistically enhances the anticancer efficiency of VS5584 in human osteosarcoma cells.
ClC-5 Downregulation Induces Osteosarcoma Cell Apoptosis by Promoting Bax and tBid Complex Formation.
Combinatorial screening using orthotopic patient derived xenograft-expanded early phase cultures of osteosarcoma identify novel therapeutic drug combinations.
Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells.
Effects of phorbol esters and pertussis toxin on agonist-stimulated cyclic AMP production in rat osteosarcoma cells.
Evidence against roles for pertussis toxin sensitive G proteins or diacylglycerol generation in insulin-like growth factor-1 stimulated DNA synthesis in MG-63 osteosarcoma cells.
Fluoroquinolone-mediated inhibition of cell growth, s-g(2)/m cell cycle arrest, and apoptosis in canine osteosarcoma cell lines.
Hydrogen peroxide-induced poly(ADP-ribosyl)ation regulates osteogenic differentiation-associated cell death.
Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells.
Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo.
Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells.
Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.
Interferon-? Sensitises Human Osteosarcoma Cells to Trail-mediated Apoptosis.
Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication.
Isoalantolactone inhibits constitutive NF-?B activation and induces reactive oxygen species-mediated apoptosis in osteosarcoma U2OS cells through mitochondrial dysfunction.
Knockdown of PARP-1 Inhibits Proliferation and ERK Signals, Increasing Drug Sensitivity in Osteosarcoma U2OS Cells.
Maclurin exerts anti-cancer effects in human osteosarcoma cells via prooxidative activity and modulations of PARP, p38, and ERK signaling.
Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway.
Osteosarcoma cells with genetic signatures of BRCAness are susceptible to the PARP inhibitor talazoparib alone or in combination with chemotherapeutics.
PARP1 modulates telomere sister chromatid exchange and telomere length homeostasis by regulating telomere localization of SLX4 in U2OS cells.
Poly(ADP-ribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA.
Poly(ADP-ribosyl)ation of p53 in vitro and in vivo modulates binding to its DNA consensus sequence.
Regulation of DNAS1L3 endonuclease activity by poly(ADP-ribosyl)ation during etoposide-induced apoptosis. Role of poly(ADP-ribose) polymerase-1 cleavage in endonuclease activation.
Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells.
Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.
Selenocysteine inhibits human osteosarcoma cells growth through triggering mitochondrial dysfunction and ROS-mediated p53 phosphorylation.
Tankyrase1 antisense oligodeoxynucleotides suppress the proliferation, migration and invasion through Hippo/YAP pathway in human osteosarcoma cells.
Targeted inhibition of mTORC2 prevents osteosarcoma cell migration and promotes apoptosis.
The effect of 3-aminobenzamide, inhibitor of poly(ADP-ribose) polymerase, on human osteosarcoma cells.
The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma.
The poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide suppresses cell growth and migration, enhancing suppressive effects of cisplatin in osteosarcoma cells.
Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis.
[The clonal evolution of osteosarcomas].
Ototoxicity
Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment.
Baicalin attenuates gentamicin-induced cochlear hair cell ototoxicity.
Dunnione ameliorates cisplatin ototoxicity through modulation of NAD(+) metabolism.
Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy.
Ovarian Neoplasms
(+)-Strebloside-Induced Cytotoxicity in Ovarian Cancer Cells Is Mediated through Cardiac Glycoside Signaling Networks.
53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer.
53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
A case of immune-mediated liver injury induced by Olaparib.
A comprehensive look of poly(ADP-ribose) polymerase inhibition strategies and future directions for cancer therapy.
A Critical Appraisal and Recommendations for Cost-Effectiveness Studies of Poly(ADP-Ribose) Polymerase Inhibitors in Advanced Ovarian Cancer.
A decade of clinical development of PARP inhibitors in perspective.
A first-in-class CDK4 inhibitor demonstrates in vitro, ex-vivo and in vivo efficacy against ovarian cancer.
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
A genomic instability score in discriminating nonequivalent outcomes of BRCA1/2 mutations and in predicting outcomes of ovarian cancer treated with platinum-based chemotherapy.
A label-free PFP-based photoelectrochemical biosensor for highly sensitive detection of PARP-1 activity.
A PET imaging agent for evaluating PARP-1 expression in ovarian cancer.
A Population Pharmacokinetic Meta-Analysis of Veliparib, a PARP Inhibitor, Across Phase 1/2/3 Trials in Cancer Patients.
A profile on the FoundationFocus CDxBRCA tests.
A Quantitative Chemotherapy Genetic Interaction Map Reveals Factors Associated with PARP Inhibitor Resistance.
A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells.
A randomized Phase II study of veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in BRCA1/2 metastatic breast cancer: design and rationale.
A review of PARP inhibitors: from bench to bedside.
A Review on Poly (ADP-ribose) Polymerase (PARP) Inhibitors and Synthetic Methodologies.
A Small Compound KJ-28d Enhances the Sensitivity of Non-Small Cell Lung Cancer to Radio- and Chemotherapy.
A small molecule compound inhibits AKT pathway in ovarian cancer cell lines.
ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells.
Adherence to PARP inhibitor therapy among women with ovarian cancer.
Administration of the Tablet Formulation of Olaparib in Patients with Ovarian Cancer: Practical Guidance and Expectations.
ADP-Ribosylation Levels and Patterns Correlate with Gene Expression and Clinical Outcomes in Ovarian Cancers.
Advanced epithelial ovarian cancer: from standard chemotherapy to promising molecular pathway targets--where are we now?
Advancements in PARP1 Targeted Nuclear Imaging and Theranostic Probes.
Advances in PARP inhibitors for the treatment of breast cancer.
Advances in the Treatment of Ovarian Cancer Using PARP Inhibitors and the Underlying Mechanism of Resistance.
Advances in the treatment of platinum resistant epithelial ovarian cancer: an update on standard and experimental therapies.
Advances in the use of PARP inhibitor therapy for breast cancer.
Advances in the use of PARP inhibitors for BRCA1/2-associated breast cancer: talazoparib.
Advances in using PARP inhibitors to treat cancer.
Advancing Drug Development in Gynecologic Malignancies.
Adverse events of PARP inhibitors.
ALDH1A1 contributes to PARP inhibitor resistance via enhancing DNA repair in BRCA2-/- ovarian cancer cells.
Amplification of the Mutation-Carrying BRCA2 Allele Promotes RAD51 Loading and PARP Inhibitor Resistance in the Absence of Reversion Mutations.
An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel-resistant ovarian cancer cells.
An Effective Epigenetic-PARP inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA-mutations.
An ex vivo assay of XRT-induced Rad51 foci formation predicts response to PARP-inhibition in ovarian cancer.
An HTS-compatible HTRF assay measuring the glycohydrolase activity of human PARG.
An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy.
Anti-angiogenesis for cancer: Current status and prospects.
Anti-Tumor Xanthones from Garcinia nujiangensis Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells.
Anticancer activity of pristimerin in ovarian carcinoma cells is mediated through the inhibition of prosurvival Akt/NF-?B/mTOR signaling.
Anticancer potential of diarylidenyl piperidone derivatives, HO-4200 and H-4318, in cisplatin resistant primary ovarian cancer.
Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells.
Antitumor Activity of 3-Indolylmethanamines 31B and PS121912.
Antitumor activity of the poly(ADP-ribose) polymerase inhibitor rucaparib as monotherapy in patients with platinum-sensitive, relapsed, BRCA-mutated, high-grade ovarian cancer, and an update on safety.
Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer.
Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP.
Application and reflection of genomic scar assays in evaluating the efficacy of platinum salts and PARP inhibitors in cancer therapy.
Appraising iniparib, the PARP inhibitor that never was--what must we learn?
Assessment and management of diarrhea following VEGF receptor TKI treatment in patients with ovarian cancer.
Association between polymorphisms of XRCC1 and ADPRT genes and ovarian cancer survival with platinum-based chemotherapy in Chinese population.
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
ATR and p-ATR are emerging prognostic biomarkers and DNA damage response targets in ovarian cancer.
ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.
Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers.
Augmentation of the antitumor effects of PARP inhibitors in triple-negative breast cancer via degradation by hydrophobic tagging modulation.
Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
Autoimmune response to PARP and BRCA1/BRCA2 in cancer.
Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2?) pathway protect ovarian cancer cells from metformin-induced apoptosis.
AZD1775 Increases Sensitivity to Olaparib and Gemcitabine in Cancer Cells with p53 Mutations.
Bacillus intermedius ribonuclease (BINASE) induces apoptosis in human ovarian cancer cells.
Baseline clinical predictors of antitumor response to the PARP inhibitor olaparib in germline BRCA1/2 mutated patients with advanced ovarian cancer.
Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition.
BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer.
BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer.
Bevacizumab or PARP-Inhibitors Maintenance Therapy for Platinum-Sensitive Recurrent Ovarian Cancer: A Network Meta-Analysis.
Beyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated and BRCA-Like Solid Tumors.
Biologicals in the Upfront Treatment of Ovarian Cancer: Focus on Bevacizumab and Poly (ADP-Ribose) Polymerase Inhibitors.
Biomarkers of Response and Resistance to DNA Repair Targeted Therapies.
Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.
BRCA 1/2-Mutation Related and Sporadic Breast and Ovarian Cancers: More Alike than Different.
BRCA Genetic Test and Risk-Reducing Salpingo-Oophorectomy for Hereditary Breast and Ovarian Cancer: State-of-the-Art.
BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives.
BRCA somatic mutations and epigenetic BRCA modifications in serous ovarian cancer.
BRCA1 and BRCA2 mutations and clinical interpretation in 398 ovarian cancer patients: comparison with breast cancer variants in a similar population.
BRCA1- and BRCA2-related mutations: therapeutic implications in ovarian cancer.
BRCA1-2 diagnostic workflow from next-generation sequencing technologies to variant identification and final report.
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
BRCA1/2 somatic mutation detection in formalin-fixed paraffin embedded tissue by next-generation sequencing in Korean ovarian cancer patients.
BRCA1/2 testing: therapeutic implications for breast cancer management.
Breast Cancer Predisposition Genes and Synthetic Lethality.
C/EBP? promotes poly(ADP-ribose) polymerase inhibitor resistance by enhancing homologous recombination repair in high-grade serous ovarian cancer.
Can integrative biomarker approaches improve prediction of platinum and PARP inhibitor response in ovarian cancer?
Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting.
Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes.
Candidate synthetic lethality partners to PARP inhibitors in the treatment of ovarian clear cell cancer.
Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells.
CCNE1 Is a Putative Therapeutic Target for ARID1A-Mutated Ovarian Clear Cell Carcinoma.
CDCA8, targeted by MYBL2, promotes malignant progression and olaparib insensitivity in ovarian cancer.
CDK9 inhibitor CDKI-73 is synergetic lethal with PARP inhibitor olaparib in BRCA1 wide-type ovarian cancer.
Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51.
Cediranib, a pan-VEGFR inhibitor, and olaparib, a PARP inhibitor, in combination therapy for high grade serous ovarian cancer.
Ceralasertib-Mediated ATR Inhibition Combined With Olaparib in Advanced Cancers Harboring DNA Damage Response and Repair Alterations (Olaparib Combinations).
Changes in gene expression variability reveal a stable synthetic lethal interaction network in BRCA2- ovarian cancers.
Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance.
Chemotherapy and PARP inhibitors in heavily pretreated BRCA1/2 mutation ovarian cancer (BMOC) patients.
Chemotherapy directly followed by poly(ADP-ribose) polymerase inhibition as an alternative to surgery in patients with BRCA-mutated ovarian cancer: a potential management strategy in the era of coronavirus disease 2019.
Chemotherapy reduces PARP1 in cancers of the ovary: implications for future clinical trials involving PARP inhibitors.
Choosing wisely: Selecting PARP inhibitor combinations to promote anti-tumor immune responses beyond BRCA mutations.
Circulating HOXA9-methylated tumour DNA: A novel biomarker of response to poly (ADP-ribose) polymerase inhibition in BRCA-mutated epithelial ovarian cancer.
Clinical Application of Poly(ADP-Ribose) Polymerase Inhibitors in High-Grade Serous Ovarian Cancer.
Clinical benefit of systemic therapies for recurrent ovarian cancer-ESMO-MCBS scores.
Clinical features and outcomes of germline mutation BRCA1-linked versus sporadic ovarian cancer patients.
Clinical perspectives of BET inhibition in ovarian cancer.
Clinical trials and future potential of targeted therapy for ovarian cancer.
Co-treatment with BEZ235 Enhances Sensitivity of BRCA1-negative Breast Cancer Cells to Olaparib.
Combination of erlotinib and a PARP inhibitor inhibits growth of A2780 tumor xenografts due to increased autophagy.
Combination of Niraparib, Cisplatin and Twist Knockdown in Cisplatin-Resistant Ovarian Cancer Cells Potentially Enhances Synthetic Lethality through ER-Stress Mediated Mitochondrial Apoptosis Pathway.
Combination of PARP Inhibitor Olaparib, and PD-L1 Inhibitor Durvalumab, in Recurrent Ovarian Cancer: a Proof-of-Concept Phase II Study.
Combination Platinum-based and DNA Damage Response-targeting Cancer Therapy: Evolution and Future Directions.
Combination treatment with cisplatin, paclitaxel and olaparib has synergistic and dose reduction potential in ovarian cancer cells.
Combinatorial therapy of immune checkpoint and cancer pathways provides a novel perspective on ovarian cancer treatment.
Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes.
Combined PARP and Immune Checkpoint Inhibition in Ovarian Cancer.
Combined Strategies with Poly (ADP-Ribose) Polymerase (PARP) Inhibitors for the Treatment of Ovarian Cancer: A Literature Review.
Combined Targeted Resequencing of Cytosine DNA Methylation and Mutations of DNA Repair Genes with Potential Use for Poly(ADP-Ribose) Polymerase 1 Inhibitor Sensitivity Testing.
Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors.
Combining PARP and CDK4/6 inhibitors in MYC driven ovarian cancer.
Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models.
Combining PI3K and PARP inhibitors for breast and ovarian cancer treatment.
Comparative Assessment of Diagnostic Homologous Recombination Deficiency-Associated Mutational Signatures in Ovarian Cancer.
Comparative Efficacy and Safety of PARP Inhibitors as Maintenance Therapy in Platinum Sensitive Recurrent Ovarian Cancer: A Network Meta-Analysis.
Comparing poly (ADP-ribose) polymerase inhibitors with standard chemotherapy in BRCA-mutated, recurrent ovarian cancer: lessons learned from a negative trial.
Comparison of PARPis with Angiogenesis Inhibitors and Chemotherapy for Maintenance in Ovarian Cancer: A Network Meta-Analysis.
Comparison of Poly (ADP-ribose) Polymerase Inhibitors (PARPis) as Maintenance Therapy for Platinum-Sensitive Ovarian Cancer: Systematic Review and Network Meta-Analysis.
Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.
Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors.
Concordance between CA-125 and RECIST progression in patients with germline BRCA-mutated platinum-sensitive relapsed ovarian cancer treated in the SOLO2 trial with olaparib as maintenance therapy after response to chemotherapy.
Consolidated BRCA1/2 Variant Interpretation by MH BRCA Correlates with Predicted PARP Inhibitor Efficacy Association by MH Guide.
Controversies on the treatment of ovarian cancer with dose-dense chemotherapy.
Conventional chemotherapy and oncogenic pathway targeting in ovarian carcinosarcoma using a patient-derived tumorgraft.
Copy number deletion of RAD50 as predictive marker of BRCAness and PARP inhibitor response in BRCA wild type ovarian cancer.
Corrigendum to 'Chemotherapy and PARP inhibitors in heavily pretreated BRCA1/2 mutation ovarian cancer (BMOC) patients' [Gynecologic Oncology 152 (2019) 270-277].
Corrigendum to 'The forefront of ovarian cancer therapy: update on PARP inhibitors': [Annals of Oncology 31 (2020) 1148-1159].
Cost-effectiveness analysis comparing "PARP inhibitors-for-all" to the biomarker-directed use of PARP inhibitor maintenance therapy for newly diagnosed advanced stage ovarian cancer.
Cost-effectiveness of BRCA1 and BRCA2 mutation testing to target PARP inhibitor use in platinum-sensitive recurrent ovarian cancer.
Cost-Effectiveness of Niraparib and Olaparib as Maintenance Therapy for Patients with Platinum-Sensitive Recurrent Ovarian Cancer.
Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer.
CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer.
Current role of poly(ADP-ribose) polymerase inhibitors: which poly(ADP-ribose) polymerase inhibitor and when?
Current status and future prospects of PARP inhibitor clinical trials in ovarian cancer.
Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status.
Current Systemic Treatment Landscape of Advanced Gynecologic Malignancies.
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.
CX-5461 can destabilize replication forks in PARP inhibitor-resistant models of ovarian cancer.
Cytocidal Antitumor Effects against Human Ovarian Cancer Cells Induced by B-Lactam Steroid Alkylators with Targeted Activity against Poly (ADP-Ribose) Polymerase (PARP) Enzymes in a Cell-Free Assay.
Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.
Decision analysis for secondline maintenance treatment of platinum sensitive recurrent ovarian cancer: a review.
Defective DNA repair in hereditary ovarian cancers: Implications for therapy.
Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints.
Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer.
Detecting the mutational signature of homologous recombination deficiency in clinical samples.
Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.
Development of a multiparameter flow cytometric assay as a potential biomarker for homologous recombination deficiency in women with high-grade serous ovarian cancer.
Development of new poly(ADP-ribose) polymerase (PARP) inhibitors in ovarian cancer: Quo Vadis?
Development of Olaparib for BRCA-Deficient Recurrent Epithelial Ovarian Cancer.
Development of PARP inhibitors in gynecological malignancies.
Differences in PARP Inhibitors for the Treatment of Ovarian Cancer: Mechanisms of Action, Pharmacology, Safety, and Efficacy.
Differential regulation of breast cancer bone metastasis by PARP1 and PARP2.
Directing the use of DDR kinase inhibitors in cancer treatment.
Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy.
Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy.
Distinct implications of different BRCA mutations: efficacy of cytotoxic chemotherapy, PARP inhibition and clinical outcome in ovarian cancer.
Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer.
Diverse mechanisms of PARP inhibitor resistance in ovarian cancer.
DNA Damage Repair Inhibitor for Breast Cancer Treatment.
DNA damage response as a therapeutic target in gynecological cancers.
DNA double-strand break repair pathway choice - from basic biology to clinical exploitation.
DNA repair proteins as therapeutic targets in ovarian cancer.
DNA replication stress and emerging prospects for PARG inhibitors in ovarian cancer therapy.
DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors.
Drug conjugation to hyaluronan widens therapeutic indications for ovarian cancer.
Drug therapy for hereditary cancers.
DUETTE: a phase II randomized, multicenter study to investigate the efficacy and tolerability of a second maintenance treatment in patients with platinum-sensitive relapsed epithelial ovarian cancer, who have previously received poly(ADP-ribose) polymerase (PARP) inhibitor maintenance treatment.
Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer.
Editorial.
Effect of Amino Acids on the Generation of Ginsenoside Rg3 Epimers by Heat Processing and the Anticancer Activities of Epimers in A2780 Human Ovarian Cancer Cells.
Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies.
Effect of PARP Inhibitors as Maintenance Treatment on Restricted Mean Survival Time in Platinum-Sensitive Recurrent Ovarian Cancer: A Systematic Review and Meta-analysis.
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts.
Effects of PARP-1 inhibitor and ERK inhibitor on epithelial mesenchymal transitions of the ovarian cancer SKOV3 cells.
Effects of poly (ADP-ribosyl) polymerase (PARP) inhibitor on cisplatin resistance & proliferation of the ovarian cancer C13* cells.
Efficacy and Prognostic Factors for PARP Inhibitors in Patients With Ovarian Cancer.
Efficacy and safety of anti-PD-1-based therapy in combination with PARP inhibitors for patients with advanced solid tumors in a real-world setting.
Efficacy and safety of olaparib maintenance therapy in platinum-sensitive ovarian cancer patients with BRCA mutations: a meta-analysis on randomized controlled trials.
Efficacy and safety of olaparib monotherapy in germline BRCA1/2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy.
Efficacy and Safety of PARP Inhibitor Combination Therapy in Recurrent Ovarian Cancer: A Systematic Review and Meta-Analysis.
Efficacy and safety of PARP inhibitors as the maintenance therapy in ovarian cancer: a meta-analysis of nine randomized controlled trials.
Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials.
Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study.
Emerging drugs for the treatment of ovarian cancer: a focused review of PARP inhibitors.
Emerging role of immune checkpoint inhibitors in the treatment of ovarian cancer.
Emerging treatment options for ovarian cancer: focus on rucaparib.
Emerging treatment options for recurrent ovarian cancer: the potential role of olaparib.
Enhanced Efficacy of Combined Therapy with Checkpoint Kinase 1 Inhibitor and Rucaparib Via Regulation of Rad-51 Expression in BRCA Wild-Type Epithelial Ovarian Cancer Cells.
Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase.
Enhancing chemotherapy response with bmi-1 silencing in ovarian cancer.
Epigenetic synthetic lethality approaches in cancer therapy.
ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers.
ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer.
Evaluating the potential of kinase inhibitors to suppress DNA repair and sensitise ovarian cancer cells to PARP inhibitors.
Evaluation of rucaparib and companion diagnostics in the PARP inhibitor landscape for recurrent ovarian cancer therapy.
Evaluation of the epidemiological and prognosis significance of ESR2 rs3020450 polymorphism in ovarian cancer.
Evidence for tight coupling of Gi protein-mediated lysophosphatidic acid receptor to stimulated cytokine production in ovarian cancer cell.
EVOLVE: A Multicenter Open-Label Single-Arm Clinical and Translational Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer after PARP Inhibition Progression.
Exceptional Response to Olaparib in a Patient With Recurrent Ovarian Cancer and an Entire BRCA1 Germline Gene Deletion.
Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence.
Exploiting replicative stress in gynecological cancers as a therapeutic strategy.
Exploiting the Prevalence of Homologous Recombination Deficiencies in High-Grade Serous Ovarian Cancer.
Exploring and comparing adverse events between PARP inhibitors.
Expression of PD-L1 in ovarian cancer and its synergistic antitumor effect with PARP inhibitor.
Expression of potential biomarkers associated with homologous recombination repair in patients with ovarian or triple-negative breast cancer.
Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer.
Extending the scope of PARP inhibitors in ovarian cancer.
EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer.
EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition.
FDA Approval of PARP Inhibitors and the Impact on Genetic Counseling and Genetic Testing Practices.
FDA Approval Summary: Olaparib Monotherapy or in Combination with Bevacizumab for the Maintenance Treatment of Patients with Advanced Ovarian Cancer.
FDA approves PARP inhibitor for ovarian cancer.
First-line PARP inhibition in ovarian cancer - standard of care for all?
First-line PARP inhibitors in ovarian cancer: summary of an ESMO Open - Cancer Horizons round-table discussion.
Front-line ovarian cancer maintenance therapy: PARP inhibitors for all?
Frontline PARP inhibitor maintenance therapy in ovarian cancer: A Society of Gynecologic Oncology practice statement.
Frontline therapy of ovarian cancer: trials and tribulations.
Further Analyses Highlight Benefits of PARP Inhibitors As Frontline Maintenance in Ovarian Cancer.
Gene Panel Tumor Testing in Ovarian Cancer Patients Significantly Increases the Yield of Clinically Actionable Germline Variants beyond BRCA1/BRCA2.
Genetic and epigenetic heterogeneity of epithelial ovarian cancer and the clinical implications for molecular targeted therapy.
Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.
Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer.
Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers.
Genomic LOH May Predict Rucaparib Response in Ovarian Cancer.
Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers.
Genomic, Transcriptomic, and Functional Alterations in DNA Damage Response Pathways as Putative Biomarkers of Chemotherapy Response in Ovarian Cancer.
Genomic-Based Therapy of Gynecologic Malignancies.
Germline and somatic mutations of homologous recombination-associated genes in Japanese ovarian cancer patients.
Germline mutations in Black patients with ovarian, fallopian tube and primary peritoneal carcinomas.
GnRH-R-Targeted Lytic Peptide Sensitizes BRCA Wild-type Ovarian Cancer to PARP Inhibition.
Gynecologic Cancers: Emerging Novel Strategies for Targeting DNA Repair Deficiency.
HER2 Overexpression Renders Human Breast Cancers Sensitive to PARP Inhibition Independently of Any Defect in Homologous Recombination DNA Repair.
Hereditary ovarian carcinomas: clinico-biological features and treatment.
Hereditary pancreatic cancer.
High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer.
High resolution melting profiles (HRMPs) obtained by magnetic induction cycler (MIC) have been used to monitor the BRCA2 status highlighted by next generation tumor sequencing (NGTS): a combined approach in a diagnostic environment.
HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.
Homologous recombination deficiency and ovarian cancer.
Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management.
How safe is rucaparib in ovarian cancer?
Identification of biomarkers complementary to homologous recombination deficiency for improving the clinical outcome of ovarian serous cystadenocarcinoma.
Identification of BRCA1-deficient ovarian cancers.
Identification of DNA Repair Pathways that Affect the Survival of Ovarian Cancer Cells Treated with a PARP Inhibitor in a Novel Drug Combination.
Identification of Novel Biomarkers of Homologous Recombination Defect in DNA Repair to Predict Sensitivity of Prostate Cancer Cells to PARP-Inhibitors.
Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells.
Identifying and Overcoming Mechanisms of PARP Inhibitor Resistance in Homologous Recombination Repair-Deficient and Repair-Proficient High Grade Serous Ovarian Cancer Cells.
Identifying the need to refine the potential patient risk factors for niraparib-induced thrombocytopenia.
Immune System and DNA Repair Defects in Ovarian Cancer: Implications for Locoregional Approaches.
Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives.
Impact of proactive high-throughput functional assay data on BRCA1 variant interpretation in 3684 patients with breast or ovarian cancer.
In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer.
In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma.
Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer.
Increased single-strand annealing rather than non-homologous end-joining predicts hereditary ovarian carcinoma.
Inducing Synthetic Lethality using PARP Inhibitors.
Induction of apoptosis by the new anticancer drug XK469 in human ovarian cancer cell lines.
Inherited gynaecological cancers.
Inhibition of Hec1 expression enhances the sensitivity of human ovarian cancer cells to paclitaxel.
Inhibition of poly(ADP)-ribose polymerase as a therapeutic strategy for breast cancer.
Inhibition of Poly(ADP-Ribose) Polymerase Enhances Radiochemosensitivity in Cancers Proficient in DNA Double-Strand Break Repair.
Inhibition of poly(ADP-ribose) polymerase induces synthetic lethality in BRIP1 deficient ovarian epithelial cells.
Inhibition of proliferation and invasiveness of ovarian cancer C13* cells by a poly(ADP-ribose) polymerase inhibitor and the role of nuclear factor-?B.
Inhibition of the MYC-regulated glutaminase metabolic axis is an effective synthetic lethal approach for treating chemoresistant cancers.
Inhibitory PARP w terapii raka jajnika.
Intraperitoneal delivery of NanoOlaparib for disseminated late-stage cancer treatment.
Involvement of homologous recombination in the synergism between cisplatin and poly(ADP-ribose) polymerase inhibition.
It is not all about BRCA: Cullin-Ring ubiquitin Ligases in ovarian cancer.
Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer.
Latest clinical evidence and further development of PARP inhibitors in ovarian cancer.
Layer-by-layer nanoparticles for novel delivery of cisplatin and PARP inhibitors for platinum-based drug resistance therapy in ovarian cancer.
Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1.
Leveraging DNA repair deficiency in gynecologic oncology.
Lived experiences of women reporting fatigue during PARP inhibitor maintenance treatment for advanced ovarian cancer: A qualitative study.
Long-term response to Olaparib in carcinomatous meningitis of a BRCA2 mutated ovarian cancer: A case report.
Long-term safety in patients with recurrent ovarian cancer treated with niraparib versus placebo: Results from the phase III ENGOT-OV16/NOVA trial.
Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness.
Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells.
Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.
Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance.
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.
LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair.
Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer.
Magnitude of benefit of the addition of poly ADP-ribose polymerase (PARP) inhibitors to therapy for malignant tumor: A meta-analysis.
Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells.
Maintenance Poly (ADP-ribose) Polymerase Inhibitor Therapy for Ovarian Cancer: Precision Oncology or One Size Fits All?
Major clinical research advances in gynecologic cancer in 2018.
Major clinical research advances in gynecologic cancer in 2019.
Major clinical research advances in gynecologic cancer in 2020.
Making the best of PARP inhibitors in ovarian cancer.
Manage wisely: poly (ADP-ribose) polymerase inhibitor (PARPi) treatment and adverse events.
Management of Adverse Events During Rucaparib Treatment for Relapsed Ovarian Cancer: A Review of Published Studies and Practical Guidance.
Management of nausea and vomiting from poly(ADP-ribose) polymerase inhibitor therapy for advanced ovarian cancer.
Management of newly diagnosed or recurrent ovarian cancer.
Managing recurrent ovarian cancer in daily clinical practice: case studies and evidence review with a focus on the use of trabectedin.
Mapping genetic interactions in cancer: a road to rational combination therapies.
Mechanism and current progress of Poly ADP-ribose polymerase (PARP) inhibitors in the treatment of ovarian cancer.
Mechanisms of PARP inhibitor resistance in ovarian cancer.
Mechanisms of PARP inhibitor sensitivity and resistance.
Medicinal chemistry approaches of poly ADP-Ribose polymerase 1 (PARP1) inhibitors as anticancer agents - A recent update.
MicroRNA-506-3p increases the response to PARP inhibitors and cisplatin by targeting EZH2/?-catenin in serous ovarian cancers.
MiR-216b increases cisplatin sensitivity in ovarian cancer cells by targeting PARP1.
MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC.
miR-9 regulation of BRCA1 and ovarian cancer sensitivity to cisplatin and PARP inhibition.
Missed therapeutic and prevention opportunities in women with BRCA-mutated epithelial ovarian cancer and their families due to low referral rates for genetic counseling and BRCA testing: A review of the literature.
MKP-1 suppresses PARP-1 degradation to mediate cisplatin resistance.
Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells.
Molecular and clinical predictors of improvement in progression-free survival with maintenance PARP inhibitor therapy in women with platinum-sensitive, recurrent ovarian cancer: A meta-analysis.
Molecular disruption of DNA polymerase ? for platinum sensitisation and synthetic lethality in epithelial ovarian cancers.
Molecular Pathways: Targeting DNA Repair Pathway Defects Enriched in Metastasis.
Molecular profiling and commercial predication assays in ovarian cancer: still not ready for prime time?
Molecular Testing Identifies Determinants of Exceptional Response and Guides Precision Therapy in a Patient with Lethal, Treatment-emergent Neuroendocrine Prostate Cancer.
Monepantel induces autophagy in human ovarian cancer cells through disruption of the mTOR/p70S6K signalling pathway.
Movement of Poly-ADP Ribose (PARP) Inhibition into Frontline Treatment of Ovarian Cancer.
Moving From Mutation to Actionability.
Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy.
Moving toward personalized medicine: treatment-focused genetic testing of women newly diagnosed with ovarian cancer.
Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas.
Mutation landscape of germline and somatic BRCA1/2 in patients with high-grade serous ovarian cancer.
MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer.
Myelodysplastic syndrome and acute myeloid leukaemia in patients treated with PARP inhibitors: a safety meta-analysis of randomised controlled trials and a retrospective study of the WHO pharmacovigilance database.
NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression.
Nanoformulation of Talazoparib Delays Tumor Progression and Ascites Formation in a Late Stage Cancer Model.
Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.
NEAT1 Knockdown Suppresses the Cisplatin Resistance in Ovarian Cancer by Regulating miR-770-5p/PARP1 Axis.
New developments in molecular targeted therapy of ovarian cancer.
New developments in the treatment of ovarian cancer--future perspectives.
New quantitative mass spectrometry approaches reveal different ADP-ribosylation phases dependent on the levels of oxidative stress.
New strategies in ovarian cancer: translating the molecular complexity of ovarian cancer into treatment advances.
New strategies in the treatment of ovarian cancer: current clinical perspectives and future potential.
New Targeted Agents in Gynecologic Cancers: Synthetic Lethality, Homologous Recombination Deficiency, and PARP Inhibitors.
New Therapies for Ovarian Cancer.
New treatment option for ovarian cancer: PARP inhibitors.
Next-generation sequencing-based BRCA testing on cytological specimens from ovarian cancer ascites reveals high concordance with tumour tissue analysis.
Next-Generation Sequencing-based genomic profiling of brain metastases of primary ovarian cancer identifies high number of BRCA-mutations.
Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models.
Niraparib as Maintenance Therapy in Germline ATM-mutated and Somatic BRCA2-mutated Ovarian Cancer with Brain Metastases: A Case Report and Literature Review.
Niraparib for the treatment of ovarian cancer.
Niraparib for the Treatment of Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.
Niraparib in the maintenance treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer: safety and efficacy.
Niraparib in the treatment of previously treated advanced ovarian, fallopian tube or primary peritoneal cancer.
Niraparib maintenance therapy in patients with platinum-sensitive recurrent ovarian cancer using an individualized starting dose (NORA): a randomized, double-blind, placebo-controlled phase III trial?.
Niraparib Maintenance Therapy in Patients With Recurrent Ovarian Cancer After a Partial Response to the Last Platinum-Based Chemotherapy in the ENGOT-OV16/NOVA Trial.
Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial.
Niraparib Slows Ovarian Cancer Progression.
Nobiletin Triggers Reactive Oxygen Species-Mediated Pyroptosis through Regulating Autophagy in Ovarian Cancer Cells.
Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors.
Novel pharmacological effects of poly (ADP-ribose) polymerase inhibitor rucaparib on the lactate dehydrogenase pathway.
Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.
Novel Therapeutics for Ovarian Cancer: The 11th Biennial Rivkin Center Ovarian Cancer Research Symposium.
Novel therapeutics: response and resistance in ovarian cancer.
Novel therapies, including enzastaurin, in the treatment of ovarian cancer.
Olaparib , PARP1 inhibitor in ovarian cancer.
Olaparib approved for advanced ovarian cancer.
Olaparib as maintenance treatment for patients with platinum-sensitive relapsed ovarian cancer.
Olaparib Combined with an ATR or Chk1 Inhibitor as a Treatment Strategy for Acquired Olaparib-Resistant BRCA1 Mutant Ovarian Cells.
Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial.
Olaparib for the treatment of BRCA-mutated advanced ovarian cancer.
Olaparib for the treatment of epithelial ovarian cancer.
Olaparib for the treatment of ovarian cancer.
Olaparib for the treatment of relapsed ovarian cancer with a BRCA1/2 mutation.
Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy.
Olaparib in the management of ovarian cancer.
Olaparib in the therapy of advanced ovarian cancer: first real world experiences in safety and efficacy from China.
Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer.
Olaparib maintenance monotherapy in platinum-sensitive, relapsed ovarian cancer without germline BRCA mutations: OPINION Phase IIIb study design.
Olaparib maintenance therapy in patients with newly diagnosed advanced ovarian cancer and a BRCA1 and/or BRCA2 mutation: SOLO1 China cohort.
Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial.
Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation.
Olaparib monotherapy in patients with advanced relapsed ovarian cancer and a germline BRCA1/2 mutation: a multi-study analysis of response rates and safety.
Olaparib shows promise in multiple tumor types.
Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial.
Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial.
Olaparib: a promising PARP inhibitor in ovarian cancer therapy.
Olaparib: an oral PARP-1 and PARP-2 inhibitor with promising activity in ovarian cancer.
Oncologist-led BRCA 'mainstreaming' in the ovarian cancer clinic: A study of 255 patients and its impact on their management.
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial.
Ovarian Cancer Translational Activity of the Multicenter Italian Trial in Ovarian Cancer (MITO) Group: Lessons Learned in 10 Years of Experience.
Ovarian Cancer Treatments Strategy: Focus on PARP Inhibitors and Immune Check Point Inhibitors.
Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Polymerase Inhibitors.
Ovarian Cancers Harbor Defects in Nonhomologous End Joining Resulting in Resistance to Rucaparib.
Overall survival in patients with platinum-sensitive recurrent serous ovarian cancer receiving olaparib maintenance monotherapy: an updated analysis from a randomised, placebo-controlled, double-blind, phase 2 trial.
Overcoming PARP inhibitor resistance in ovarian cancer: what are the most promising strategies?
Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review.
Pancreatic cancer: BRCA mutation and personalized treatment.
Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib.
PARP (Poly(ADP-Ribose) Polymerase) Inhibitors in Platinum-Sensitive Recurrent Ovarian Cancer: A Meta-Analysis of Randomized Controlled Trials.
PARP goes the weasel! Emerging role of PARP inhibitors in acute leukemias.
PARP inhibition and synthetic lethality in ovarian cancer.
PARP inhibition as frontline therapy in ovarian cancer.
PARP inhibition causes premature loss of cohesion in cancer cells.
PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer.
PARP inhibition in BRCA-mutated breast and ovarian cancers.
PARP Inhibition in Cancer: An Update on Clinical Development.
PARP inhibition in ovarian cancer: state of the science.
PARP inhibition in platinum-based chemotherapy: Chemopotentiation and neuroprotection.
PARP inhibition in recurrent ovarian cancer.
PARP inhibition in the ovarian cancer patient: Current approvals and future directions.
PARP Inhibition Induces Enrichment of DNA Repair-Proficient CD133 and CD117 Positive Ovarian Cancer Stem Cells.
PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer.
PARP inhibition: A promising therapeutic target in ovarian cancer.
PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers.
PARP Inhibitor in Platinum-Resistant Ovarian Cancer: Single-Center Real-World Experience.
PARP inhibitor maintenance for primary ovarian cancer - A missed opportunity for precision medicine.
PARP inhibitor maintenance therapy for patients with platinum-sensitive recurrent ovarian cancer: a cost-effectiveness analysis.
PARP inhibitor resistance: the underlying mechanisms and clinical implications.
PARP inhibitors and immunotherapy in ovarian and endometrial cancers.
PARP inhibitors and more.
PARP inhibitors and quality of life in ovarian cancer.
PARP Inhibitors and the Evolving Landscape of Ovarian Cancer Management: A Review.
PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2?
PARP Inhibitors as Frontline Treatment in Patients With Ovarian Cancer.
PARP inhibitors as maintenance therapy in newly diagnosed advanced ovarian cancer: a meta-analysis.
Parp inhibitors as maintenance treatment in platinum sensitive recurrent ovarian cancer: An updated meta-analysis of randomized clinical trials according to BRCA mutational status.
PARP inhibitors decrease response to subsequent platinum-based chemotherapy in patients with BRCA mutated ovarian cancer.
PARP Inhibitors Display Differential Efficacy in Models of BRCA Mutant High-Grade Serous Ovarian Cancer.
PARP inhibitors for all ovarian cancers.
PARP inhibitors for BRCA wild type ovarian cancer; gene alterations, homologous recombination deficiency and combination therapy.
PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions.
PARP inhibitors for ovarian cancer.
PARP Inhibitors for Ovarian Cancer: Current Indications, Future Combinations, and Novel Assets in Development to Target DNA Damage Repair.
PARP inhibitors for targeted treatment in ovarian cancer.
Parp Inhibitors for the Treatment of Ovarian Cancer.
PARP inhibitors in BRCA gene-mutated ovarian cancer and beyond.
PARP inhibitors in BRCA mutation-associated ovarian cancer.
PARP inhibitors in breast and ovarian cancer with BRCA mutations: a meta-analysis of survival.
PARP inhibitors in epithelial ovarian cancer.
PARP Inhibitors in First-Line Therapy of Ovarian Cancer: Are There Any Doubts?
PARP inhibitors in older patients with ovarian and breast cancer: Young International Society of Geriatric Oncology review paper.
PARP Inhibitors in Ovarian Cancer Treatment.
PARP inhibitors in ovarian cancer.
PARP Inhibitors in Ovarian Cancer.
PARP inhibitors in ovarian cancer.
PARP Inhibitors in Ovarian Cancer.
PARP Inhibitors in Ovarian Cancer. Reply.
PARP Inhibitors in Ovarian Cancer: A Trailblazing and Transformative Journey.
PARP inhibitors in ovarian cancer: An overview of the practice-changing trials.
PARP inhibitors in ovarian cancer: Clinical evidence for informed treatment decisions.
PARP inhibitors in ovarian cancer: Current status and future promise.
PARP inhibitors in ovarian cancer: evidence for maintenance and treatment strategies.
PARP inhibitors in ovarian cancer: evidence, experience and clinical potential.
PARP inhibitors in ovarian cancer: Sensitivity prediction and resistance mechanisms.
PARP Inhibitors in Ovarian Cancer: The Route to "Ithaca".
PARP Inhibitors in Pancreatic Cancer: From Phase I to Plenary Session.
PARP Inhibitors in Patients With Newly Diagnosed Advanced Ovarian Cancer: A Meta-Analysis of Randomized Clinical Trials.
PARP inhibitors in platinum-sensitive high-grade serous ovarian cancer.
PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.
PARP inhibitors in the treatment of ovarian cancer: a review.
PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer.
PARP inhibitors promote stromal fibroblast activation by enhancing CCL5 autocrine signaling in ovarian cancer.
PARP inhibitors.
PARP inhibitors: A new era of targeted therapy.
PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance.
PARP inhibitors: Clinical utility and possibilities of overcoming resistance.
PARP Theranostic Auger Emitters Are Cytotoxic in BRCA Mutant Ovarian Cancer and Viable Tumors from Ovarian Cancer Patients Enable Ex-Vivo Screening of Tumor Response.
PARP-1 Expression Quantified by [
PARP-1 inhibitor modulate ?-catenin signaling to enhance cisplatin sensitivity in cancer cervix.
PARP-1 may be involved in angiogenesis in epithelial ovarian cancer.
PARP1 blockade is synthetically lethal in XRCC1 deficient sporadic epithelial ovarian cancers.
PARP1 Is Targeted by miR-519a-3p and Promotes the Migration, Invasion, and Tube Formation of Ovarian Cancer Cells.
PARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy.
PARP1 Suppresses the Transcription of PD-L1 by Poly(ADP-Ribosyl)ating STAT3.
PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow.
Patient preferences for maintenance PARP inhibitor therapy in ovarian cancer treatment.
Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing.
Pharmaceutical Management of Ovarian Cancer: Current Status.
Pharmacokinetics and clinical response to single agent rucaparib in a dialysis dependent patient with BRCA associated breast and recurrent ovarian cancer.
Pharmacological ascorbate induces 'BRCAness' and enhances the effects of Poly(ADP-Ribose) polymerase inhibitors against BRCA1/2 wild-type ovarian cancer.
Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid Tumors.
Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in patients with advanced ovarian cancer and other solid malignancies.
Phase I study of olaparib in combination with liposomal doxorubicin in patients with advanced solid tumours.
Phase I Study of Rucaparib in Combination with Bevacizumab in Ovarian Cancer Patients: Maximum Tolerated Dose and Pharmacokinetic Profile.
Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors.
Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer.
Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer.
Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer.
Poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors as maintenance therapy in women with newly diagnosed ovarian cancer: a systematic review and meta-analysis.
Poly (ADP-ribose) polymerase (PARP) inhibitor regimens for ovarian cancer in phase III randomized controlled trials: a network meta-analysis.
Poly (ADP-ribose) polymerase 1 transcriptional regulation: a novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer.
Poly (ADP-ribose) polymerase inhibitors combined with other small-molecular compounds for the treatment of ovarian cancer.
Poly (ADP-ribose) polymerase inhibitors in the management of ovarian cancer.
Poly (ADP-ribose) Polymerase Inhibitors in the Management of Ovarian Cancer: A Drug Class Review.
Poly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond.
Poly (ADP-Ribose) Polymerases (PARPs) and PARP Inhibitor-Targeted Therapeutics.
Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models.
Poly(ADP-ribose) polymerase (PARP) inhibitors and ovarian cancer.
Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer.
Poly(ADP-ribose) polymerase activity and inhibition in cancer.
Poly(ADP-Ribose) Polymerase Inhibition Synergizes with 5-Fluorodeoxyuridine but not 5-Fluorouracil in Ovarian Cancer Cells.
Poly(ADP-ribose) polymerase inhibitor therapeutic effect: are we just scratching the surface?
Poly(ADP-ribose) polymerase inhibitors as maintenance treatment in patients with newly diagnosed advanced ovarian cancer: a meta-analysis.
Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer.
Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression.
Poly(ADP-ribosyl)ation polymerases: mechanism and new target of anticancer therapy.
Poly-ADP-ribose polymerase inhibitor use in ovarian cancer: expanding indications and novel combination strategies.
Poly-ADP-ribosyl-polymerase inhibitor resistance mechanisms and their therapeutic implications.
Potential role of HGF-PARP-1 signaling in invasion of ovarian cancer cells.
Practical guidance for the management of side effects during rucaparib therapy in a multidisciplinary UK setting.
Practical guidance on the use of olaparib capsules as maintenance therapy for women with BRCA mutations and platinum-sensitive recurrent ovarian cancer.
Preclinical evaluation of olaparib and metformin combination in BRCA1 wildtype ovarian cancer.
Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer.
Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine.
Prevalence and clinical significance of BRCA1/2 germline and somatic mutations in Taiwanese patients with ovarian cancer.
Prevalence of hereditary breast and ovarian cancer (HBOC) predisposition gene mutations among 882 HBOC high-risk Chinese individuals.
Prexasertib, a cell cycle checkpoint kinases 1 and 2 inhibitor, increases
Profile of olaparib in the treatment of advanced ovarian cancer.
Prognostic nomogram for progression-free survival in patients with BRCA mutations and platinum-sensitive recurrent ovarian cancer on maintenance olaparib therapy following response to chemotherapy.
Progress in the treatment of ovarian cancer-lessons from homologous recombination deficiency-the first 10 years.
Prolonged response to treatment based on cell-free DNA analysis and molecular profiling in three patients with metastatic cancer: a case series.
Promoter hypomethylation, especially around the E26 transformation-specific motif, and increased expression of poly (ADP-ribose) polymerase 1 in BRCA-mutated serous ovarian cancer.
Proteomic Analysis of the Downstream Signaling Network of PARP1.
Quality of life during olaparib maintenance therapy in platinum-sensitive relapsed serous ovarian cancer.
Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies.
Randomized Trial of Oral Cyclophosphamide and Veliparib in High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers, or BRCA-Mutant Ovarian Cancer.
Rapid Progression of Metastatic Pancreatic Adenocarcinoma During Platinum-Based Therapy in a Patient Harboring a Pathogenic BRCA2 Germline Variant.
Ratio-Dependent Synergism of a Doxorubicin and Olaparib Combination in 2D and Spheroid Models of Ovarian Cancer.
Rationale for combination PARP inhibitor and antiangiogenic treatment in advanced epithelial ovarian cancer: A review.
Recent advances in targeting DNA repair pathways for the treatment of ovarian cancer and their clinical relevance.
Recent Patents for Homologous Recombination Deficiency Assays Among Women with Ovarian Cancer.
Recent progress in the diagnosis and treatment of ovarian cancer.
Reciprocal positive selection for weakness - preventing olaparib resistance by inhibiting BRCA2.
Recommendations for the implementation of BRCA testing in ovarian cancer patients and their relatives.
RECQL4, Negatively Regulated by miR-10a-5p, Facilitates Cell Proliferation and Invasion via MAFB in Ovarian Cancer.
Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition.
Research progress on the association between environmental pollutants and the resistance mechanism of PARP inhibitors in ovarian cancer.
Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib: A case report.
Response to Olaparib in a Patient with Germline BRCA2 Mutation and Breast Cancer Leptomeningeal Carcinomatosis.
REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
Risk of selected gastrointestinal toxicities associated with poly (ADP-ribose) polymerase (PARP) inhibitors in the treatment of ovarian cancer: a meta-analysis of published trials.
Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors.
Role of Olaparib as Maintenance Treatment for Ovarian Cancer: The Evidence to Date.
Role of Poly (ADP-Ribose) Polymerase inhibitors beyond BReast CAncer Gene-mutated ovarian tumours: definition of homologous recombination deficiency?
Role of Poly Adenosine Diphosphate Ribose Polymerase Inhibitors in Advanced Stage Ovarian Cancer.
Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction.
Rucaparib and Niraparib in Advanced Ovarian Cancer.
Rucaparib Approved for Ovarian Cancer.
Rucaparib in ovarian cancer: extending the use of PARP inhibitors in the recurrent disease.
Rucaparib in the landscape of PARP inhibition in ovarian cancer.
Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.
Rucaparib: A Poly(ADP-Ribose) Polymerase Inhibitor for BRCA-Mutated Relapsed Ovarian Cancer.
Rucaparib: An emerging parp inhibitor for treatment of recurrent ovarian cancer.
Rucaparib: the past, present, and future of a newly approved PARP inhibitor for ovarian cancer.
Safety evaluation of olaparib for treating ovarian cancer.
SEOM clinical guideline in ovarian cancer (2020).
Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1.
Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel.
Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples.
Single-particle analysis of full-length human poly(ADP-ribose) polymerase 1.
Somatic mRNA Analysis of BRCA1 Splice Variants Provides a Direct Theranostic Impact on PARP Inhibitors.
Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer.
SPSB1 enhances ovarian cancer cell survival by destabilizing p21.
Stenoparib, an Inhibitor of Cellular Poly(ADP-Ribose) Polymerase, Blocks Replication of the SARS-CoV-2 and HCoV-NL63 Human Coronaviruses In Vitro.
Strategic Combination Therapies for Ovarian Cancer.
Structure-based design of an agonistic peptide targeting Fas.
Success for First-Line PARP Inhibition in Ovarian Cancer.
Successes and limitations of targeted cancer therapy in ovarian cancer.
Successful Treatment of Patients with Refractory High-Grade Serous Ovarian Cancer with GOPC-ROS1 Fusion Using Crizotinib: A Case Report.
Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo.
Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells.
Synergistic Effect of Bazedoxifene and PARP Inhibitor in the Treatment of Ovarian Cancer Regardless of BRCA Mutation.
Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells.
Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities.
Synthetic lethal therapies for cancer: what's next after PARP inhibitors?
Synthetic Lethality - Its Current Application and Potential in Oncological Treatment.
Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage.
Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition.
Synthetic Lethality in Ovarian Cancer.
Synthetic oleanane triterpenoid, CDDO-Me, induces apoptosis in ovarian cancer cells by inhibiting prosurvival AKT/NF-?B/mTOR signaling.
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.
Systematic inhibitor selectivity between PARP1 and PARP2 enzymes: Molecular implications for ovarian cancer personalized therapy.
Targeted agents and combinations in ovarian cancer: where are we now?
Targeted composite value-based endpoints in platinum-sensitive recurrent ovarian cancer.
Targeted therapies in epithelial ovarian cancer: Molecular mechanisms of action.
Targeted therapies in gynaecological cancers.
Targeted Therapies in the Management of Ovarian Cancer: A Focus on Older Patients.
Targeted therapy for gynecologic cancers: Toward the era of precision medicine.
Targeted therapy for ovarian cancer: the rapidly evolving landscape of PARP inhibitor use.
Targeted therapy in ovarian cancer.
Targeted therapy: ARIEL3 - broad benefit of PARP inhibitors in ovarian cancer.
Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based drug combinations.
Targeting CARM1 in ovarian cancer with EZH2 and PARP inhibitors.
Targeting DNA repair and replication stress in the treatment of ovarian cancer.
Targeting DNA Repair in Cancer: Beyond PARP Inhibitors.
Targeting DNA repair: the genome as a potential biomarker.
Targeting genetic and epigenetic alterations in the treatment of serous ovarian cancer.
Targeting Human Poly(ADP-Ribose) Polymerase-1 with Natural Medicines and Its Potential Applications in Ovarian Cancer Therapeutics.
Targeting on poly(ADP-ribose) polymerase activity with DNA-damaging hybrid lactam-steroid alkylators in wild-type and BRCA1-mutated ovarian cancer cells.
Targeting the ATR/CHK1 axis with PARP inhibition results in tumor regression in BRCA mutant ovarian cancer models.
The Association of Polymorphisms in Base Excision Repair Genes with Ovarian Cancer Susceptibility in Chinese Women: A Two-Center Case-Control Study.
The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer.
The BRCA1 ubiquitin ligase and homologous recombination repair.
The BRCA1-?11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.
The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition.
The CHK1 inhibitor SRA737 synergizes with PARP1 inhibitors to kill carcinoma cells.
The current landscape of molecular profiling in the treatment of epithelial ovarian cancer.
The current status of PARP inhibitors in ovarian cancer.
The development of PARP inhibitors in ovarian cancer: from bench to bedside.
The Development of Rucaparib/Rubraca®: A Story of the Synergy Between Science and Serendipity.
The DNA damaging revolution.
The DNA Damaging Revolution: PARP Inhibitors and Beyond.
The dystonia gene THAP1 controls DNA double-strand break repair choice.
The effect of age on efficacy, safety and patient-centered outcomes with rucaparib: A post hoc exploratory analysis of ARIEL3, a phase 3, randomized, maintenance study in patients with recurrent ovarian carcinoma.
The effect of food on the pharmacokinetics of niraparib, a poly(ADP-ribose) polymerase (PARP) inhibitor, in patients with recurrent ovarian cancer.
The efficacy and safety of niraparib for ovarian cancer: a single-center observational study from China.
The efficacy and safety of olaparib in the treatment of cancers: a meta-analysis of randomized controlled trials.
The efficacy and safety of the addition of poly ADP-ribose polymerase (PARP) inhibitors to therapy for ovarian cancer: a systematic review and meta-analysis.
The Era of PARP inhibitors in ovarian cancer: "Class Action" or not? A systematic review and meta-analysis.
The financial burden of PARP inhibitors on patients, payors, and financial assistance programs: Who bears the cost?
The First Nationwide Multicenter Prevalence Study of Germline BRCA1 and BRCA2 Mutations in Chinese Ovarian Cancer Patients.
The forefront of ovarian cancer therapy: update on PARP inhibitors.
The Importance of Distinguishing Sporadic Cancers from Those Related to Cancer Predisposing Germline Mutations.
The influence of long non-coding RNAs on the response to chemotherapy in ovarian cancer.
The integration of BRCA testing into oncology clinics.
The irreversible ERBB1/2/4 inhibitor neratinib interacts with the PARP1 inhibitor niraparib to kill ovarian cancer cells.
The Landscape and Therapeutic Implications of Molecular Profiles in Epithelial Ovarian Cancer.
The maze of PARP inhibitors in ovarian cancer.
The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1(-/-) murine model of ovarian cancer.
The potential of PARP inhibitors in genetic breast and ovarian cancers.
The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation.
The preferences of women with ovarian cancer for oral versus intravenous recurrence regimens.
The Prognostic Relevance of Poly (ADP-Ribose) Polymerase Expression in Ovarian Cancer Tissue of Wild Type and BRCA-Mutation Carrier Patients.
The Prognostic Value of PARP Expression in High-Grade Epithelial Ovarian Cancer.
The promising PARP inhibitors in ovarian cancer therapy: From Olaparib to others.
The Role of Cediranib in Ovarian Cancer.
The role of PARP inhibitors in germline BRCA-associated pancreatic ductal adenocarcinoma.
The Role of PARP Inhibitors in the Ovarian Cancer Microenvironment: Moving Forward From Synthetic Lethality.
The Role of PARP Inhibitors in the Treatment of Ovarian Carcinomas.
The Role of PARPs in Inflammation-and Metabolic-Related Diseases: Molecular Mechanisms and Beyond.
The role of poly(ADP-ribose) polymerase inhibitors in the treatment of cancer and methods to overcome resistance: a review.
The safety of antiangiogenic agents and PARP inhibitors in platinum-sensitive recurrent ovarian cancer.
The status of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in ovarian cancer, part 1: olaparib.
The status of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in ovarian cancer, part 2: extending the scope beyond olaparib and BRCA1/2 mutations.
The systemic treatment of recurrent ovarian cancer revisited.
The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency.
The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy-Current progress and future direction.
The WRN helicase: resolving a new target in microsatellite unstable cancers.
Therapeutic applications of PARP inhibitors in ovarian cancer.
Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond.
Therapeutic Implications of Germline Testing in Patients With Advanced Cancers.
Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer.
Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer.
Therapeutic targeting and patient selection for cancers with homologous recombination defects.
Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer.
Total and out-of-pocket costs for PARP inhibitors among insured ovarian cancer patients.
Translational Highlights in Breast and Ovarian Cancer 2019 - Immunotherapy, DNA Repair, PI3K Inhibition and CDK4/6 Therapy.
Triapine Disrupts CtIP-Mediated Homologous Recombination Repair and Sensitizes Ovarian Cancer Cells to PARP and Topoisomerase Inhibitors.
Tumor burden is a potential marker of PARP inhibitor effects in ovarian cancer: a head-to-head observational series.
Two decades beyond BRCA1/2: Homologous recombination, hereditary cancer risk and a target for ovarian cancer therapy.
U.S. Food and Drug Administration-Approved Poly (ADP-Ribose) Polymerase Inhibitor Maintenance Therapy for Recurrent Ovarian Cancer: A Cost-Effectiveness Analysis.
UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/?-catenin signaling pathway.
UK BRCA mutation testing in patients with ovarian cancer.
Understanding Exceptional Responses to Poly (ADP-ribose) Polymerase Inhibition in Sporadic Ovarian Cancer.
Unveiling the mechanistic roles of chlorine substituted phthalazinone-based compounds containing chlorophenyl moiety towards the differential inhibition of poly (ADP-ribose) polymerase-1 in the treatment of lung cancer.
Update in the use and evaluation of poly (ADP-ribose) polymerase inhibitors in epithelial ovarian cancer: current and pending clinical research.
Update on PARP Inhibitors in Breast Cancer.
Update on PARP1 inhibitors in ovarian cancer.
Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment.
Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic.
Using PARP Inhibitors in Advanced Ovarian Cancer.
Using PARP Inhibitors in Frontline Maintenance Therapy for Ovarian Cancer.
Using PARP Inhibitors in the Treatment of Patients With Ovarian Cancer.
USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response.
Veliparib for the treatment of ovarian cancer.
What Is the Place of PARP Inhibitors in Ovarian Cancer Treatment?
When in the treatment continuum to use PARP inhibition in ovarian cancer.
ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo.
[BRCA diagnostics of ovarian cancer : Molecular tumor testing since the introduction of PARP inhibitor therapy].
[Cancer therapy by PARP inhibitors].
[DNA repair as a therapeutic target].
[From poly(ADP-ribose) discovery to PARP inhibitors in cancer therapy].
[Medical treatment options in BRCA-associated cancers].
[Molecular Targeted Therapies for Hereditary Cancer Syndrome].
[On the prospects of using the DNA repair inhibitors in radiotherapy of tumors].
[PARP INHIBITORS FOR ADJUVANT TREATMENT FOR OVARIAN CANCER].
[PARP inhibitors--theoretical basis and clinical application].
[PARP inhibitors: new therapeutic agents in breast and ovarian cancer].
[Recommended Extension of Indication Criteria for Genetic Testing of BRCA1 and BRCA2 Mutations in Hereditary Breast and Ovarian Cancer Syndrome].
[Testing of mutations in BRCA1 and BRCA2 genes in tumor tissues - possibilities and limitations].
[The Antitumor Effects of Fisetin on Ovarian Cancer in vitro and in vivo.]
Overweight
Reduced mitogenicity of sera following weight loss in premenopausal women.
Pancreatic Neoplasms
A decade of clinical development of PARP inhibitors in perspective.
A novel somatic BRCA2 point mutation in a metastatic pancreatic cancer patient: a case report.
A PARP inhibitor in pancreatic cancer: Enhancement anti-tumour activity of chemoradiation therapy against pancreatic cancer?
A Review on Poly (ADP-ribose) Polymerase (PARP) Inhibitors and Synthetic Methodologies.
Acquired multiple secondary BRCA2 mutations upon PARPi resistance in a metastatic pancreatic cancer patient harboring a BRCA2 germline mutation.
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.
Analysis Suggests Wider Use for PARP Inhibitors.
ATM-Mutated Pancreatic Cancer: Clinical and Molecular Response to Gemcitabine/Nab-Paclitaxel After Genome-Based Therapy Resistance.
Autoimmune response to PARP and BRCA1/BRCA2 in cancer.
BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation.
BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives.
BRCA2 secondary mutation-mediated resistance to platinum and PARP inhibitor-based therapy in pancreatic cancer.
BRCAness as a Biomarker of Susceptibility to PARP Inhibitors in Glioblastoma Multiforme.
C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage.
Combination of AZD2281 (Olaparib) and GX15-070 (Obatoclax) results in synergistic antitumor activities in preclinical models of pancreatic cancer.
Combination therapy of poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide and gemcitabine shows strong antitumor activity in pancreatic cancer cells.
Combinative effects of ?-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation.
Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination-Proficient Pancreatic Cancer.
Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer.
Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells.
Complete pathological response to olaparib and bevacizumab in advanced cervical cancer following chemoradiation in a BRCA1 mutation carrier: a case report.
Cost-Effectiveness of Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer.
Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells.
Current treatment landscape and emerging therapies for pancreatic cancer.
Cytoplasmic PARP-1 promotes pancreatic cancer tumorigenesis and resistance.
DNA damage induced by KP372-1 hyperactivates PARP1 and enhances lethality of pancreatic cancer cells with PARP inhibition.
Down-expression of poly(ADP-ribose) polymerase in p53-regulated pancreatic cancer cells.
Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells.
Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts.
Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein.
Enoxacin with UVA Irradiation Induces Apoptosis in the AsPC1 Human Pancreatic Cancer Cell Line Through ROS Generation.
Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 ( BRCA2) Mutation.
Evidence for the efficacy of Iniparib, a PARP-1 inhibitor, in BRCA2-associated pancreatic cancer.
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells.
Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer.
Gemcitabine-Based Chemoradiotherapy Enhanced by a PARP Inhibitor in Pancreatic Cancer Cell Lines.
Genomic instability in pancreatic adenocarcinoma: a new step towards precision medicine and novel therapeutic approaches.
Genotype-phenotype correlation in BRCA1/2 mutation-associated pancreatic cancer.
Germinal BRCA1-2 pathogenic variants (gBRCA1-2pv) and pancreatic cancer: epidemiology of an Italian patient cohort.
Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors.
Health-related quality of life in patients with a germline BRCA mutation and metastatic pancreatic cancer receiving maintenance olaparib.
Hereditary pancreatic cancer.
High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer.
Inactivation of the prolyl isomerase Pin1 sensitizes BRCA1-proficient breast cancer to PARP inhibition.
JF-305, a pancreatic cancer cell line is highly sensitive to the PARP inhibitor olaparib.
Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress.
Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.
Maintenance Rucaparib Controls Some Pancreatic Cancers.
Maintenance therapies in metastatic pancreatic cancer: present and future with a focus on PARP inhibitors.
Metformin Inhibits Gemcitabine Induced Apoptosis in Pancreatic Cancer Cell Lines.
MicroRNA-7 modulates cellular senescence to relieve gemcitabine resistance by targeting PARP1/NF-?B signaling in pancreatic cancer cells.
More PARP Inhibitors in Pancreatic Cancer?
MTA2 sensitizes gastric cancer cells to PARP inhibition by induction of DNA replication stress.
Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells.
Olaparib Monotherapy for Previously Treated Pancreatic Cancer With DNA Damage Repair Genetic Alterations Other Than Germline BRCA Variants: Findings From 2 Phase 2 Nonrandomized Clinical Trials.
Opportunities for Utilization of DNA Repair Inhibitors in Homologous Recombination Repair-Deficient and Proficient Pancreatic Adenocarcinoma.
Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity.
Oral Poly(ADP-Ribose) Polymerase-1 Inhibitor BSI-401 Has Antitumor Activity and Synergizes with Oxaliplatin against Pancreatic Cancer, Preventing Acute Neurotoxicity.
Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis.
Paradigm Shifting of Systemic Chemotherapy for Unresectable Pancreatic Cancer in Japan.
PARP inhibition - opportunities in pancreatic cancer.
PARP inhibition in treatment of pancreatic cancer.
PARP Inhibitor Drugs In The Treatment Of Breast, Ovarian, Prostate And Pancreatic Cancers: An Update of Clinical Trials.
PARP Inhibitors in Pancreatic Cancer: From Phase I to Plenary Session.
PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications.
PARP inhibitors: shifting the paradigm in the treatment of pancreatic cancer.
Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer.
PARP-1 Regulates Resistance of Pancreatic Cancer to TRAIL Therapy.
PARP10 (ARTD10) modulates mitochondrial function.
PARP14 promotes the proliferation and gemcitabine chemoresistance of pancreatic cancer cells through activation of NF-?B pathway.
Phase II Study of Maintenance Rucaparib in Patients With Platinum-Sensitive Advanced Pancreatic Cancer and a Pathogenic Germline or Somatic Variant in BRCA1, BRCA2, or PALB2.
Poly (ADP-ribose) polymerase inhibitor, an effective radiosensitizer in lung and pancreatic cancers.
Poly(ADP-ribose) polymerase inhibition in pancreatic cancer.
Poly(ADP-Ribose) Polymerase Inhibitors in Pancreatic Cancer: A New Treatment Paradigms and Future Implications.
Poly(ADP-Ribose) Polymerases: New Players in the Pathogenesis of Exocrine Pancreatic Diseases.
Predictive and prognostic biomarkers in personalized gastrointestinal cancer treatment.
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
Radioimmunotherapy of human pancreatic cancer xenografts in NOD-scid mice with [64Cu]Cu-NOTA-panitumumab F(ab')2 alone or combined with radiosensitizing gemcitabine and the PARP inhibitor, rucaparib.
Radiosensitization Effect of PARP Inhibition in Cells Exposed to Low and High LET Radiation.
Radiosensitization of Pancreatic Cancer Cells In Vitro and In Vivo through Poly (ADP-ribose) Polymerase Inhibition with ABT-888.
Radiosensitizing Pancreatic Cancer with PARP Inhibitor and Gemcitabine: An In Vivo and a Whole-Transcriptome Analysis after Proton or Photon Irradiation.
Rucaparib Monotherapy in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation.
Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1.
Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
Targeted PARP Inhibition Combined with FGFR1 Blockade is Synthetically Lethal to Malignant Cells in Patients with Pancreatic Cancer.
Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.
Tephrosin induces apoptosis of human pancreatic cancer cells through the generation of reactive oxygen species.
The promise and current status of CDK12/13 inhibition for the treatment of cancer.
The role of PARP inhibitors in BRCA mutated pancreatic cancer.
The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm.
Ultra-violet irradiation induces apoptosis via mitochondrial pathway in pancreatic cancer cells.
Update on the Role of Poly (ADP-Ribose) Polymerase Inhibitors in the DNA Repair-Deficient Pancreatic Cancers: A Narrative Review.
Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.
[Medical treatment options in BRCA-associated cancers].
[The long coding RNA GSTM3TV2 acts an oncogene to promote chemoresistance in pancreatic cancer].
Pancreatitis
Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice.
Does the 3-aminobenzamide effect on bacterial translocation affect experimental acute necrotizing pancreatitis?
Effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, in a mouse model of acute pancreatitis induced by cerulein.
Effects of The Poly(ADP-ribose) Polymerase Inhibitor Olaparib in Cerulein-Induced Pancreatitis.
Inhibition of Poly(ADP-Ribose) Polymerase Attenuates Acute Kidney Injury in Sodium Taurocholate-Induced Acute Pancreatitis in Rats.
Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury.
Parp1 deficient mice are protected from streptozotocin-induced diabetes but not caerulein-induced pancreatitis, independent of the induction of Reg family genes.
Poly(ADP-Ribose) Polymerase 1 Promotes Inflammation and Fibrosis in a Mouse Model of Chronic Pancreatitis.
Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis.
Poly(ADP-Ribose) Polymerases: New Players in the Pathogenesis of Exocrine Pancreatic Diseases.
Stabilization of exocytosis by dynamic F-actin coating of zymogen granules in pancreatic acini.
Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury.
Pancreatitis, Acute Necrotizing
Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis.
Pancreatitis, Chronic
Poly(ADP-Ribose) Polymerase 1 Promotes Inflammation and Fibrosis in a Mouse Model of Chronic Pancreatitis.
Panniculitis
Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review.
Papilloma
Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives.
Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin.
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts.
Poly(ADP-ribosyl)ation and aging.
Retraction: Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin.
Papillomavirus Infections
Expression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV).
Paraganglioma
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Paralysis
CCR5 knockout suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice.
HIV-1 Tat protein attenuates the clinical course of experimental autoimmune encephalomyelitis (EAE).
Maraviroc attenuates the pathogenesis of experimental autoimmune encephalitis.
Myelin oligodendrocyte glycoprotein (MOG35-55)-induced experimental autoimmune encephalomyelitis is ameliorated in interleukin-32 alpha transgenic mice.
Paraproteinemias
Altered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma.
Exploiting MYC-induced PARPness to target genomic instability in multiple myeloma.
Targeting the MALAT1/PARP1/LIG3 complex induces DNA damage and apoptosis in multiple myeloma.
Parasitic Diseases
Transient inhibition of poly(ADP-ribose) polymerase expression and activity by Toxoplasma gondii is dispensable for parasite-mediated blockade of host cell apoptosis and intracellular parasite replication.
Paratuberculosis
Induction of humoral immunity in response to immunization with recombinant Mycobacterium bovis BCG expressing the S1 subunit of Bordetella pertussis toxin.
Parkinson Disease
A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice.
A PARP-1 Feed-Forward Mechanism To Accelerate ?-Synuclein Toxicity in Parkinson's Disease.
Association analysis of PARP1 polymorphisms with Parkinson's disease.
Computational Analysis Indicates That PARP1 Acts as a Histone Deacetylases Interactor Sharing Common Lysine Residues for Acetylation, Ubiquitination, and SUMOylation in Alzheimer's and Parkinson's Disease.
Effects of Poly (ADP-ribose) Polymerase Inhibitor 3-Aminobenzamide on Blood-Brain Barrier and Dopaminergic Neurons of Rats with Lipopolysaccharide-Induced Parkinson's Disease.
Evaluation of a Low-Toxicity PARP Inhibitor as a Neuroprotective Agent for Parkinson's Disease.
FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration.
Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death.
Implication of poly (ADP-ribose) polymerase (PARP) in neurodegeneration and brain energy metabolism. Decreases in mouse brain NAD+ and ATP caused by MPTP are prevented by the PARP inhibitor benzamide.
Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity.
Mediation of cell death by poly(ADP-ribose) polymerase-1.
Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
PARP Inhibitors and Parkinson's Disease.
Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease.
PARP-1 involvement in neurodegeneration: A focus on Alzheimer's and Parkinson's diseases.
PARP1 and CASP3 gene expression in a patient with multiple head and neck squamous cell carcinoma and Parkinson disease.
Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.
Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson's disease.
Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models.
Poly (ADP-ribose) in the pathogenesis of Parkinson's disease.
Poly (ADP-ribose) polymerase 1 and Parkinson's disease: A study in post-mortem human brain.
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes ?-synuclein degradation via transcription factor EB-dependent autophagy in mutant ?-synucleinA53T model of Parkinson's disease.
Poly (ADP-ribose) polymerase-1 (PARP-1) -410C/T polymorphism in Sicilian patients with Parkinson's disease.
Poly (ADP-ribose) polymerase-1 (PARP-1) genetic variants are protective against Parkinson's disease.
Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases.
Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism.
Rhododendrin-Induced RNF146 Expression via Estrogen Receptor ? Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress.
Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies.
The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease.
The neuroprotective effect of nicotine in Parkinson's disease models is associated with inhibiting PARP-1 and caspase-3 cleavage.
Untangling the genetic link between type 1 and type 2 diabetes using functional genomics.
[Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase]
Parkinsonian Disorders
Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy.
NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase.
Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism.
Poly(ADP-Ribose) polymerase-1 in acute neuronal death and inflammation: a strategy for neuroprotection.
Poly(ADP-ribosyl)ation enzyme-1 as a target for neuroprotection in acute central nervous system injury.
Whooping cough and Parkinson's disease. The Europarkinson Preparatory Activity Research Group.
Periodontal Diseases
5-Aminoisoquinolin-1(2H)-one, a water-soluble poly (ADP-ribose) polymerase (PARP) inhibitor reduces the evolution of experimental periodontitis in rats.
Role of poly(ADP-ribose) polymerase activation in the pathogenesis of periodontitis in diabetes.
Periodontitis
5-Aminoisoquinolin-1(2H)-one, a water-soluble poly (ADP-ribose) polymerase (PARP) inhibitor reduces the evolution of experimental periodontitis in rats.
Hematogenous apoptotic mechanism in salivary glands in chronic periodontitis.
Role of poly(ADP-ribose) polymerase activation in the pathogenesis of periodontitis in diabetes.
Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis.
Peripheral Nervous System Diseases
Can Poly (ADP-Ribose) Polymerase Inhibitors Palliate Paclitaxel-Induced Peripheral Neuropathy in Patients With Cancer?
Concurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy.
Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy.
Morin Mitigates Chronic Constriction Injury (CCI)-Induced Peripheral Neuropathy by Inhibiting Oxidative Stress Induced PARP Over-Activation and Neuroinflammation.
Nicotinamide reverses neurological and neurovascular deficits in streptozotocin diabetic rats.
PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: Correlation with peripheral nerve function.
PARP inhibition attenuates neuroinflammation and oxidative stress in chronic constriction injury induced peripheral neuropathy.
Poly (ADP-Ribose) Polymerase Inhibition for Chemotherapy-Induced Peripheral Neuropathy: A Meta-Analysis of Placebo-Controlled Trials.
Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice.
Peritoneal Fibrosis
Poly(ADP-ribose) polymerase-1 in high glucose-induced epithelial-mesenchymal transition during peritoneal fibrosis.
Peritoneal Neoplasms
A Phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy in patients with advanced solid malignancies and peritoneal carcinomatosis.
Peritonitis
Moesin regulates neutrophil rolling velocity in vivo.
Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.
Persistent Hyperplastic Primary Vitreous
Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease.
Persistent Infection
Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections.
Pheochromocytoma
Accentuation by pertussis toxin of the 5-hydroxytryptamine-induced potentiation of ATP-evoked responses in rat pheochromocytoma cells.
Betagamma subunits of G(i/o) suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced.
Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death.
Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity.
Neuromodulatory effects of atrial natriuretic factor are independent of guanylate cyclase in adrenergic neuronal pheochromocytoma cells.
Nitric oxide induces apoptosis via AP-1-driven upregulation of COX-2 in rat pheochromocytoma cells.
Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C.
PolyADP-ribosylation is involved in neurotrophic activity.
Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells.
Tetrachlorobenzoquinone triggers the cleavage of Bid and promotes the cross-talk of extrinsic and intrinsic apoptotic signalings in pheochromocytoma (PC) 12 cells.
Photosensitivity Disorders
Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells.
Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization.
Photodynamic therapy-induced death of MCF-7 human breast cancer cells: a role for caspase-3 in the late steps of apoptosis but not for the critical lethal event.
Pituitary Neoplasms
Pertussis toxin blocks somatostatin's inhibition of stimulated cyclic AMP accumulation in anterior pituitary tumor cells.
Pertussis toxin distinguishes between muscarinic receptor-mediated inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in Flow 9000 cells.
Pertussis toxin inhibits somatostatin-induced K+ conductance in human pituitary tumor cells.
Pertussis toxin modifies the characteristics of both the inhibitory GTP binding proteins and the somatostatin receptor in anterior pituitary tumor cells.
Pertussis toxin treatment blocks the inhibition of somatostatin and increases the stimulation by forskolin of cyclic AMP accumulation and adrenocorticotropin secretion from mouse anterior pituitary tumor cells.
Phospholipase C activation in rat pituitary adenoma (GH) cells.
The role of poly (adenosine 5'-diphosphate-ribose) polymerase in the response of pituitary tumor cells to reactive oxygen species.
Placenta, Retained
Poly(ADP-ribose) polymerase in bovine retained and not retained placenta.
Plasmacytoma
Characterization of the poly(ADP-ribose) polymerase associated with free cytoplasmic mRNA-protein particles.
Pleurisy
Critical role of L-selectin and histamine H4 receptor in zymosan-induced neutrophil recruitment from the bone marrow: comparison with carrageenan.
Identification of autoantibodies associated with systemic lupus erythematosus.
Pneumococcal Infections
Vaccines, emerging viruses, and how to avoid disaster.
Pneumonia
Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation.
Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits.
Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach.
Functional Polymorphisms of Base Excision Repair Genes XRCC1 and APEX1 Predict Risk of Radiation Pneumonitis in Patients with Non-Small Cell Lung Cancer Treated with Definitive Radiation Therapy.
Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma.
Inhibition of poly (adenosine diphosphate-ribose) polymerase attenuates lung-kidney crosstalk induced by intratracheal lipopolysaccharide instillation in rats.
Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis.
Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation.
PARP inhibitor, olaparib ameliorates acute lung and kidney injury upon intratracheal administration of LPS in mice.
PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice.
Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib ameliorates influenza-virus-induced pneumonia in mice.
Phenotypic comparison of Pseudomonas aeruginosa strains isolated from a variety of clinical sites.
Poly (ADP-ribose) polymerase 14 and its enzyme activity regulates T(H)2 differentiation and allergic airway disease.
Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling.
Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: a potential specific effect on IL-5.
Poly(ADP-Ribose)Polymerase-1 in Lung Inflammatory Disorders: A Review.
Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation.
Pseudomonas aeruginosa exoenzyme S induces transcriptional expression of proinflammatory cytokines and chemokines.
Pseudomonas aeruginosa exoenzyme S is a mitogen but not a superantigen for human T lymphocytes.
Risk of pneumonitis in cancer patients treated with PARP inhibitors: A meta-analysis of randomized controlled trials and a pharmacovigilance study of the FAERS database.
Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction.
The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia.
The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice.
TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation.
Ubiquitin-Specific Protease 14 (USP14) Aggravates Inflammatory Response and Apoptosis of Lung Epithelial Cells in Pneumonia by Modulating Poly (ADP-Ribose) Polymerase-1 (PARP-1).
Poliomyelitis
A Randomized, Controlled Study of DTaP-IPV-HB-PRP-T, a Fully Liquid Hexavalent Vaccine, Administered in a 3-, 5- and 11- to 12-month Schedule.
Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children.
Humoral immunity of dTap-IPV vaccine (REPEVAX(®)) administered one month after dT-IPV vaccine (REVAXIS(®)) in adults with unknown vaccination history.
Immunogenicity and reactogenicity of diphtheria, tetanus and pertussis toxoids combined with inactivated polio vaccine, when administered concomitantly with or as a diluent for a Hib conjugate vaccine.
Immunogenicity and Safety of Monovalent Acellular Pertussis Vaccine at Birth: A Randomized Clinical Trial.
Repeated administration of whole-cell and acellular pertussis vaccines affects haemodynamics and autonomic responsiveness.
Porcine Reproductive and Respiratory Syndrome
Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology.
Pre-Eclampsia
CLDN1 regulates trophoblast apoptosis and proliferation in preeclampsia.
Contribution of poly(ADP-ribose) polymerase to endothelial dysfunction and hypertension in a rat model of pre-eclampsia.
Excessive stimulation of poly(ADP-ribosyl)ation contributes to endothelial dysfunction in pre-eclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage.
Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia.
DNA repair gene XRCC1 polymorphisms in childhood acute lymphoblastic leukemia.
Good early treatment response in childhood acute lymphoblastic leukemia is associated with Bax nuclear accumulation and PARP cleavage.
Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells.
LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL.
Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin.
PARP-1 expression in CD34+ leukemic cells in childhood acute lymphoblastic leukemia: relation to response to initial therapy and other prognostic factors.
Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells.
TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition.
The interleukin 1beta-converting enzyme inhibitor CrmA prevents Apo1/Fas- but not glucocorticoid-induced poly(ADP-ribose) polymerase cleavage and apoptosis in lymphoblastic leukemia cells.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Autophagy Inhibition Potentiates the Anticancer Effects of a Bendamustine Derivative NL-101 in Acute T Lymphocytic Leukemia.
Inhibition of phosphatidylinositol 3'-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway.
LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL.
Mechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells.
TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition.
Primary Ovarian Insufficiency
Promising anti- cervical carcinoma and inflammatory agent, Resveratrol targets poly (ADP-ribose) polymerase 1 (PARP-1) induced premature ovarian failure with a potent enzymatic modulatory activity.
Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly(ADP-ribose) polymerase 1 (PARP-1).
Progeria
All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype.
Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.
Prostatic Hyperplasia
Expression of PARP-1 and its active polymer PAR in prostate cancer and benign prostatic hyperplasia in Chinese patients.
Prostatic Neoplasms
6-(3,4-Dihydro-1H-isoquinoline-2-yl)-N-(6-methoxypyridine-2-yl) nicotinamide-26 (DIMN-26) decreases cell proliferation by induction of apoptosis and downregulation of androgen receptor signaling in human prostate cancer cells.
?-Santalol, a derivative of sandalwood oil, induces apoptosis in human prostate cancer cells by causing caspase-3 activation.
A novel 3',5'-diprenylated chalcone induces concurrent apoptosis and GSDME-dependent pyroptosis through activating PKC?/JNK signal in prostate cancer.
A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer.
A novel CRISPR-engineered prostate cancer cell line defines the AR-V transcriptome and identifies PARP inhibitor sensitivities.
A Novel Use for Olaparib for Treatment of Metastatic Castration-Recurrent Prostate Cancer.
A Study of the Anti-Cancer Effects of the Hexane Fraction of the Methanol Extract of Forsythiae Fructus.
A transcriptomic model for homologous recombination deficiency in prostate cancer.
Aberrations of DNA Repair Pathways in Prostate Cancer: Future Implications for Clinical Practice?
Abiraterone-Olaparib Combo Aids Men with mCRPC.
Acquired Resistance to Poly (ADP-ribose) Polymerase Inhibitor Olaparib in BRCA2-Associated Prostate Cancer Resulting From Biallelic BRCA2 Reversion Mutations Restores Both Germline and Somatic Loss-of-Function Mutations.
Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations.
Activity of Platinum-Based Chemotherapy in Patients With Advanced Prostate Cancer With and Without DNA Repair Gene Aberrations.
Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors.
Age-related activity of Poly (ADP-Ribose) Polymerase (PARP) in men with localized prostate cancer.
Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors.
Analysis of Transcriptome, Selected Intracellular Signaling Pathways, Proliferation and Apoptosis of LNCaP Cells Exposed to High Leptin Concentrations.
Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells.
Androgen receptor inhibitor-induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer.
Anticancer effects of eleven triterpenoids derived from Antrodia camphorata.
Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells.
Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells.
ATM Loss Confers Greater Sensitivity to ATR Inhibition than PARP Inhibition in Prostate Cancer.
ATR Inhibition Induces CDK1-SPOP Signaling and Enhances Anti-PD-L1 Cytotoxicity in Prostate Cancer.
Auraptene Induces Apoptosis via Myeloid Cell Leukemia 1-Mediated Activation of Caspases in PC3 and DU145 Prostate Cancer Cells.
Auriculasin-induced ROS causes prostate cancer cell death via induction of apoptosis.
Autoimmune response to PARP and BRCA1/BRCA2 in cancer.
BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy.
Beware Liquid Biopsies to Guide PARP Blockade.
Beyond hormone therapy for prostate cancer with PARP inhibitors.
Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial.
Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model.
BRCA1 Versus BRCA2 and PARP Inhibitor Sensitivity in Prostate Cancer: More Different Than Alike?
BRCAness and prostate cancer: diagnostic and therapeutic considerations.
Breviscapine (BVP) inhibits prostate cancer progression through damaging DNA by minichromosome maintenance protein-7 (MCM-7) modulation.
Buforin IIb induces androgen-independent prostate cancer cells apoptosis though p53 pathway in vitro.
Carnosic acid modulates Akt/IKK/NF-?B signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells.
CDK12-Altered Prostate Cancer: Clinical Features and Therapeutic Outcomes to Standard Systemic Therapies, Poly (ADP-Ribose) Polymerase Inhibitors, and PD-1 Inhibitors.
Changing face of metastatic prostate cancer: the law of diminishing returns holds true.
Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition.
Clinical Development of PARP Inhibitors in Treating Metastatic Castration-Resistant Prostate Cancer.
Clinical Evolution of Epithelial-Mesenchymal Transition in Human Carcinomas.
Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes.
Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway.
CX-5461 sensitises DNA damage repair proficient castrate-resistant prostate cancer to PARP inhibition.
Design and Synthesis of a Trifunctional Molecular System "Programmed" to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-ribose) Polymerase) in Prostate Cancer Cells.
Design, synthesis and in vitro cytotoxicity studies of novel ?-carbolinium bromides.
Detection of molecular signatures of homologous recombination deficiency in prostate cancer with or without BRCA1/2 mutations.
Development of PARP inhibitor combinations for castration resistant prostate cancer unselected for homologous recombination repair mutations.
Development of PARP inhibitors in gynecological malignancies.
Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest.
DNA damage repair gene mutation testing and genetic counseling in men with/without prostate cancer: a systematic review.
DNA damage response and prostate cancer: defects, regulation and therapeutic implications.
DNA Repair and Prostate Cancer: A Field Ripe for Harvest.
DNA Repair Gene Alterations and PARP Inhibitor Response in Patients With Metastatic Castration-Resistant Prostate Cancer.
DNA Repair in Prostate Cancer: Biology and Clinical Implications.
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.
Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?
Downregulation of mTOR by lentivirus inhibits prostate cancer cell growth.
Drug and molecular radiotherapy combinations for metastatic castration resistant prostate cancer.
DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells.
Dual roles of PARP-1 promote cancer growth and progression.
Dynamic Regulation of Rad51 by E2F1 and p53 in Prostate Cancer Cells upon DrugInduced DNA Damage under Hypoxia.
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
Effects of INPP4B gene transfection combined with PARP inhibitor on castration therapy-resistant prostate cancer cell line, PC3.
Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib.
Emerging Therapies in Metastatic Prostate Cancer.
Emerging treatments for metastatic castration-resistant prostate cancer: Immunotherapy, PARP inhibitors, and PSMA-targeted approaches.
Essential role for G proteins in prostate cancer cell growth and signaling.
Evaluation of the radiosensitizing potency of chemotherapeutic agents in prostate cancer cells.
Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis.
Evolving Role of Immunotherapy in Metastatic Castration Refractory Prostate Cancer.
Exploring the selectivity of guanine scaffold in anticancer drug development by computational repurposing approach.
Expression of nuclear matrix proteins binding matrix attachment regions in prostate cancer. PARP-1: New player in tumor progression.
Expression of PARP-1 and its active polymer PAR in prostate cancer and benign prostatic hyperplasia in Chinese patients.
Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway.
Gene therapy for prostate cancer by targeting poly(ADP-ribose) polymerase.
Genetic biomarkers to guide poly(ADP-ribose) polymerase inhibitor precision treatment of prostate cancer.
Genetic polymorphisms in XRCC1 associated with radiation therapy in prostate cancer.
Germline and somatic mutations in prostate cancer: focus on defective DNA repair, PARP inhibitors and immunotherapy.
Growth Inhibitory and Pro-Apoptotic Effects of Ornamental Pomegranate Extracts in Du145 Human Prostate Cancer Cells.
HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo.
Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer.
Homologous recombination repair gene mutations in Chinese localized and locally advanced prostate cancer patients.
Honing in on PARPi Response in Prostate Cancer: from HR Pathway to Gene-by-Gene Granularity.
Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis.
ICAM-1 and AMPK regulate cell detachment and apoptosis by N-methyl-N'-nitro-N-nitrosoguanidine, a widely spread environmental chemical, in human hormone-refractory prostate cancers.
Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1).
Impact of mutations in homologous recombination repair genes on treatment outcomes for metastatic castration resistant prostate cancer.
In prostate cancer cells the interaction of C/EBPalpha with Ku70, Ku80, and poly(ADP-ribose) polymerase-1 increases sensitivity to DNA damage.
In vivo studies of the PARP inhibitor, AZD-2281, in combination with fractionated radiotherapy: An exploration of the therapeutic ratio.
Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth.
Induction of apoptosis and modulation of homologous recombination DNA repair pathway in prostate cancer cells by the combination of AZD2461 and valproic acid.
Induction of apoptosis in hormone-resistant human prostate cancer PC3 cells by inactivated Sendai virus.
Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389.
Inhibition of Myeloid Cell Leukemia 1 and Activation of Caspases Are Critically Involved in Gallotannin-induced Apoptosis in Prostate Cancer Cells.
Inhibition of PARP1 by small interfering RNA enhances docetaxel activity against human prostate cancer PC3 cells.
Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism.
Inhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death.
Integrating PARP Inhibitors Into Advanced Prostate Cancer Therapeutics.
Ionizing Radiation Combined with PARP1 Inhibitor Reduces Radioresistance in Prostate Cancer with RB1/TP53 Loss.
KNK437, a benzylidene lactam compound, sensitises prostate cancer cells to the apoptotic effect of hyperthermia.
Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness.
Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination.
Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer.
Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo.
Management of Castration-Resistant, Taxane-Resistant Prostate Cancer.
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.
Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad.
MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells.
Molecular landscape of prostate cancer: implications for current clinical trials.
Molecular mechanisms of synergistic induction of apoptosis by the combination therapy with hyperthermia and cisplatin in prostate cancer cells.
Molecular Pathways: Targeting DNA Repair Pathway Defects Enriched in Metastasis.
Molecular Testing Identifies Determinants of Exceptional Response and Guides Precision Therapy in a Patient with Lethal, Treatment-emergent Neuroendocrine Prostate Cancer.
Moving beyond PARP Inhibition in ATM-Deficient Prostate Cancer.
Mutational Profile of Aggressive, Localised Prostate Cancer from African Caribbean Men Versus European Ancestry Men.
Mutations in TP53 or DNA damage repair genes define poor prognostic subgroups in primary prostate cancer.
N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines.
Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation.
Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: analysis from the phase 2 TRITON2 study.
Non-NAD-like PARP-1 inhibitors in prostate cancer treatment.
NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.
Olaparib and rucaparib for the treatment of DNA repair-deficient metastatic castration-resistant prostate cancer.
Olaparib combined with abiraterone in patients with metastatic castration-resistant prostate cancer: a randomised, double-blind, placebo-controlled, phase 2 trial.
Olaparib effective in four advanced cancers.
Olaparib for Metastatic Castration-Resistant Prostate Cancer.
Olaparib is effective in combination with, and as maintenance therapy after, first-line endocrine therapy in prostate cancer cells.
Olaparib shows promise in multiple tumor types.
Olaparib Targets Some Advanced Prostate Cancers.
Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer.
PARP and CDK4/6 Inhibitor Combination Therapy Induces Apoptosis and Suppresses Neuroendocrine Differentiation in Prostate Cancer.
PARP inhibition in BRCA2-mutated prostate cancer.
PARP inhibition in castration-resistant prostate cancer.
PARP inhibition in prostate cancer.
PARP Inhibition in Prostate Cancer: A Promising Approach.
PARP inhibition sensitizes to low dose-rate radiation TMPRSS2-ERG fusion gene-expressing and PTEN-deficient prostate cancer cells.
PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer.
PARP inhibitor combinations in prostate cancer.
PARP inhibitor receives FDA breakthrough therapy designation in castration resistant prostate cancer: beyond germline BRCA mutations.
PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells.
PARP inhibitor-induced torsades de pointes in long QT syndrome: a case report.
PARP Inhibitors and Prostate Cancer: To Infinity and Beyond BRCA.
PARP inhibitors and stratified treatment of prostate cancer.
PARP inhibitors as a new therapeutic option in metastatic prostate cancer: a systematic review.
PARP Inhibitors for Advanced Prostate Cancer: Validating Predictive Biomarkers.
PARP inhibitors for homologous recombination-deficient prostate cancer.
PARP inhibitors in advanced prostate cancer: when to use them?
PARP inhibitors in castration-resistant prostate cancer.
PARP Inhibitors in Metastatic Prostate Cancer: Evidence to Date.
PARP Inhibitors in Prostate and Urothelial Cancers.
PARP Inhibitors in Prostate Cancer.
PARP Inhibitors in Prostate Cancer: A Promise Delivered.
PARP inhibitors in prostate cancer: practical guidance for busy clinicians.
PARP inhibitors in prostate cancer: time to narrow patient selection?
PARP Inhibitors in Prostate Cancer—The Preclinical Rationale and Current Clinical Development.
PARP-1 and CASP3 genes are up-regulated in LNCaP and PC-3 prostate cancer cell lines.
PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesis.
PARP9 is overexpressed in human breast cancer and promotes cancer cell migration.
Pharmacokinetics and safety of rucaparib in patients with advanced solid tumors and hepatic impairment.
Phenoxodiol inhibits growth of metastatic prostate cancer cells.
Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen Dependent and Androgen Independent Prostate Cancer Cells.
Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of advanced germline BRCA2 mutant prostate cancer.
Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue.
Poly (ADP-Ribose) Polymerase 1 Protein Expression in Normal Pancreas and Pancreatic Adenocarcinoma.
Poly (ADP-ribose) polymerase inhibitor: an evolving paradigm in the treatment of prostate cancer.
Poly(ADP-ribose) polymerase inhibitors in prostate and urothelial cancer.
Poly(ADP-Ribose) Polymerase Inhibitors in Prostate Cancer: Molecular Mechanisms, and Preclinical and Clinical Data.
Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease.
Polyclonal BRCA2 mutations following carboplatin treatment confer resistance to the PARP inhibitor rucaparib in a patient with mCRPC: a case report.
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer.
Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers.
Predictive value of epithelial-mesenchymal-transition (EMT) signature and PARP-1 in prostate cancer radioresistance.
Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer.
Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells.
Prostate cancer and PARP inhibitors: progress and challenges.
Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation.
Prostate cancer: Potential of PARP inhibition plus ADT in prostate cancer.
Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway.
Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3).
Quercetin-6-C-?-D-glucopyranoside, natural analog of quercetin exhibits anti-prostate cancer activity by inhibiting Akt-mTOR pathway via aryl hydrocarbon receptor.
Quo Vadis Advanced Prostate Cancer Therapy? Novel Treatment Perspectives and Possible Future Directions.
Radiation-induced PARP activation is enhanced through EGFR-ERK signaling.
Radiosynthesis of 3 H- and 14 C-labeled Veliparib.
Re: Expression of Nuclear Matrix Proteins Binding Matrix Attachment Regions in Prostate Cancer. PARP-1: New Player in Tumor Progression.
Re: Konrad H. Stopsack. Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.09.024.
Real-World Treatment Patterns and Overall Survival of Patients with Metastatic Castration-Resistant Prostate Cancer in the US Prior to PARP Inhibitors.
Recent Development and Future Prospects of Molecular Targeted Therapy in Prostate Cancer.
Relevance of poly (ADP-ribose) polymerase inhibitors in prostate cancer.
Reply to Johann S. de Bono, Maha Hussain, and Jinyu Kang's Letter to the Editor re: Konrad H. Stopsack. Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.09.024.
Research Progress on PARP14 as a Drug Target.
Resistance Mechanisms to Taxanes and PARP Inhibitors in Advanced Prostate Cancer.
Resistance to second-generation androgen receptor antagonists in prostate cancer.
Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation.
Response prediction biomarkers and drug combinations of PARP inhibitors in prostate cancer.
Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance.
Role of PARP-1 in prostate cancer.
Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration.
Salen-Mn compounds induces cell apoptosis in human prostate cancer cells through promoting AMPK activity and cell autophagy.
Sanggenol L Induces Apoptosis and Cell Cycle Arrest via Activation of p53 and Suppression of PI3K/Akt/mTOR Signaling in Human Prostate Cancer Cells.
Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells.
Sequences and combinations of multifaceted therapy in advanced prostate cancer.
SGO1 induces proliferation and metastasis of prostate cancer through AKT-mediated signaling pathway.
Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression.
SILAC-Based Mass Spectrometry Analysis Reveals That Epibrassinolide Induces Apoptosis via Activating Endoplasmic Reticulum Stress in Prostate Cancer Cells.
Similar incidence of DNA damage response pathway alterations between clinically localized and metastatic prostate cancer.
Standard treatments induce antigen-specific immune responses in prostate cancer.
Stratifying prostate patients for olaparib.
Structurally unique PARP-1 inhibitors for the treatment of prostate cancer.
Sustained Complete Response to Cytotoxic Therapy and the PARP Inhibitor Veliparib in Metastatic Castration-Resistant Prostate Cancer - A Case Report.
Synergistic action of combined PARP and ATR inhibition in prostate cancer with ATM loss.
Synergistic loss of prostate cancer cell viability by coinhibition of HDAC and PARP.
Synthesis of procaspases-3 and -7 during apoptosis in prostate cancer cells.
Synthetic lethal therapies for cancer: what's next after PARP inhibitors?
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer.
Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): an open-label, phase 2 trial.
Targeted radiosensitization of ETS fusion-positive prostate cancer through PARP1 inhibition.
Targeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012.
Targeting c-MET to Enhance the Efficacy of Olaparib in Prostate Cancer.
Targeting defective DNA repair in prostate cancer.
Targeting DNA Damage Response in Prostate and Breast Cancer.
Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer.
Targeting DNA Repair: The Role of PARP Inhibition in the Treatment of Castration-Resistant Prostate Cancer.
Targeting genotoxic and proteotoxic stress-response pathways in human prostate cancer by clinically available PARP inhibitors, vorinostat and disulfiram.
Targeting PARP in Prostate Cancer: Novelty, Pitfalls, and Promise.
Targeting Plk1 to Enhance Efficacy of Olaparib in Castration-Resistant Prostate Cancer.
Targeting poly(ADP-ribose) polymerase and the c-Myb-regulated DNA damage response pathway in castration-resistant prostate cancer.
The 25th Annual Prostate Cancer Foundation Scientific Retreat Report.
The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function.
The combined effect of USP7 inhibitors and PARP inhibitors in hormone-sensitive and castration-resistant prostate cancer cells.
The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer.
The emerging role of PARP inhibitors in prostate cancer.
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling.
The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models.
The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance.
The promising role of poly(ADP-ribose) polymerase inhibitors in prostate cancer.
The Role of PARP Inhibitors in the Treatment of Prostate Cancer: Recent Advances in Clinical Trials.
The tip of the iceberg: predicting PARP inhibitor efficacy in prostate cancer.
The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition.
Therapeutic Potential of Combining PARP Inhibitor and Immunotherapy in Solid Tumors.
Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers.
Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer.
Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target?
Treating Prostate Cancer by Antibody-Drug Conjugates.
Treatment and Patient Selection for Patients with Metastatic Castration-resistant Prostate After Progression on Docetaxel and Abiraterone/Enzalutamide: When to Play Your CARD and When to Do Your PARP.
Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1.
Untangling the PROfound Trial for Advanced Prostate Cancer: Is There Really a Role for Olaparib?
Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.
When and How to Use PARP Inhibitors in Prostate Cancer: A Systematic Review of the Literature with an Update on On-Going Trials.
[DNA damage repair: An emerging strategy in metastatic prostate cancer].
[Molecular tumor board prostate cancer].
protein acetyllysine n-acetyltransferase deficiency
Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity.
Protein Deficiency
Ageing and PARP.
protein-tyrosine-phosphatase deficiency
A cell type-specific role of protein tyrosine phosphatase non-receptor type 2 in regulating ER stress signalling.
Proteinuria
PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis.
Therapeutic options following second-line platinum-based chemotherapy in patients with recurrent ovarian cancer: Comparison of active surveillance and maintenance treatment.
protoporphyrin ferrochelatase deficiency
Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34.
Pseudomonas Infections
Production of exoenzyme S during Pseudomonas aeruginosa infections of burned mice.
Use of transposon mutants to assess the role of exoenzyme S in chronic pulmonary disease due to Pseudomonas aeruginosa.
Pseudorabies
Inhibition of PARP1 Dampens Pseudorabies Virus Infection through DNA Damage-Induced Antiviral Innate Immunity.
Psoriasis
Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin.
Poly(ADP-ribose) polymerase-1 depletion enhances the severity of inflammation in an imiquimod-induced model of psoriasis.
Pulmonary Disease, Chronic Obstructive
Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression.
Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma.
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide.
Increased DNA damage in progression of COPD: a response by poly(ADP-ribose) polymerase-1.
Increased PARP Activity and DNA Damage in NSCLC Patients: The Influence of COPD.
Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice.
Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes.
Poly(ADP-Ribose)Polymerase-1 in Lung Inflammatory Disorders: A Review.
Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients.
Theophylline prevents NAD+ depletion via PARP-1 inhibition in human pulmonary epithelial cells.
Pulmonary Edema
Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase.
Pulmonary Fibrosis
Effects of PARP-1 Deficiency and Histamine H4 Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice.
Taurine and niacin offer a novel therapeutic modality in prevention of chemically-induced pulmonary fibrosis in hamsters.
Purpura
Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura.
Rectal Neoplasms
Colorectal cancers differ in respect of PARP-1 protein expression.
DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study.
PARP inhibitors and chemoradiation for rectal cancer.
Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study.
Renal Insufficiency
Development of renal failure in PargParp-1 null and Timm23 hypomorphic mice.
Reoviridae Infections
Reovirus transport--studies using lymphocytosis promoting factor.
Reperfusion Injury
25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity.
A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging.
A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation.
A novel and orally active poly(ADP-ribose) polymerase inhibitor, KR-33889 [2-[methoxycarbonyl(4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic acid amide], attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia.
Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury.
Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging.
Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction.
Beneficial effects of poly (ADP-ribose) polymerase inhibition against the reperfusion injury in heart transplantation.
BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase.
Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase.
Continuous inhibition of poly(ADP-ribose) polymerase does not reduce reperfusion injury in isolated rat heart.
Correlation of morphological findings with functional reserve in the aging donor: role of the poly (ADP-ribose) polymerase.
Detection of poly(ADP-ribose) polymerase activation in oxidatively stressed cells and tissues using biotinylated NAD substrate.
Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.
Effect of cilostazol pretreatment on the PARP/AIF-mediated apoptotic pathway in rat cerebral ischemia-reperfusion models.
Effect of PJ-34 PARP-inhibitor on rat liver microcirculation and antioxidant status.
Effects of 3-aminobenzamide on unilateral testicular ischemia-reperfusion injury: what is the role of PARP inhibition?
Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma.
Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion injury.
Improved poststorage cardiac function by poly (ADP-ribose) polymerase inhibition: role of phosphatidylinositol 3-kinase Akt pathway.
In vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters.
Inhibition of poly(adenosine diphosphate-ribose) polymerase decreases long-term histologic damage in testicular ischemia-reperfusion injury.
Inhibition of poly(ADP-ribose) polymerase activity protects hippocampal cells against morphological and ultrastructural alteration evoked by ischemia-reperfusion injury.
Inhibition of the activity of poly (ADP-ribose) polymerase in ischemia-reperfusion injury.
Investigating the Effect of the Poly(Adp-ribose) Polymerase Inhibitor 5-aminoisoquinolinone and the Na+-H+ Exchanger Inhibitor Zoniporide on Isolated Perfused Rat Hearts during Ischemia-reperfusion Injury.
Matrix Metalloproteinase-2 (MMP-2) Gene Deletion Enhances MMP-9 Activity, Impairs PARP-1 Degradation, and Exacerbates Hepatic Ischemia and Reperfusion Injury in Mice.
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor.
Minocycline Protects Cardiac Myocytes Against Simulated Simulated Ischemia-Reperfusion Injury by Inhibiting Poly(ADP-ribose) Polymerase-1.
MiR-124 Negatively Regulated PARP1 to Alleviate Renal Ischemia-reperfusion Injury by Inhibiting TNF?/RIP1/RIP3 Pathway.
Modulation of Poly(ADP-Ribose) Polymerase-1 (PARP-1)-Mediated Oxidative Cell Injury by Ring Finger Protein 146 (RNF146) in Cardiac Myocytes.
Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation.
Neuroprotective effects of poly (ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats.
Neuroprotective Properties of Picroside II in a Rat Model of Focal Cerebral Ischemia.
Poly (ADP-Ribose) Polymerase Inhibitor Treatment as a Novel Therapy Attenuating Renal Ischemia-Reperfusion Injury.
Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.
Poly(ADP-ribose) polymerase 1 activation links ischemic acute kidney injury to interstitial fibrosis.
Poly(ADP-ribose) polymerase and renal hypothermic preservation injury.
Poly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia: its role in brain edema and cell death.
Poly(ADP-ribose) polymerase inhibition attenuates biventricular reperfusion injury after orthotopic heart transplantation.
Poly(ADP-ribose) polymerase inhibition improves postischemic myocardial function after cardioplegia-cardiopulmonary bypass.
Poly(ADP-ribose) polymerase inhibition prevents reactive oxygen species induced inhibition of aldehyde dehydrogenase2 activity.
Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation.
Poly(ADP-ribose) polymerase triggers the microvascular mechanisms of hepatic ischemia-reperfusion injury.
Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity.
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
Poly(ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury.
Poly(ADP-ribosyl)ation in asthma and other lung diseases.
Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia.
Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model.
Protective effect of cardioplegia with poly (ADP-ribose) polymerase-1 inhibitor against myocardial ischemia-reperfusion injury: in vitro study of isolated rat heart model.
Protective effects of nigranoic acid on cerebral ischemia-reperfusion injury and its mechanism involving apoptotic signaling pathway.
Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death.
Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies.
Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice.
Role of poly-(ADP-ribose) polymerase in transplant acute tubular necrosis and its relationship with delayed renal function.
Sp1 Targeted PARP1 Inhibition Protects Cardiomyocytes From Myocardial Ischemia-Reperfusion Injury via Downregulation of Autophagy.
Spermidine is protective against kidney ischemia and reperfusion injury through inhibiting DNA nitration and PARP1 activation.
The activity and inhibition of poly(ADP-ribose) polymerase-1 in equine peripheral blood mononuclear cells in vitro.
The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.
The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase.
Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy.
Respiratory Distress Syndrome
Characterization of a unique ADP-ribosyltransferase of Mycoplasma penetrans.
Poly(ADP-ribosyl)ation in asthma and other lung diseases.
Respiratory Insufficiency
[Acute poisoning by chemical warfare agent: sulfur mustard]
Respiratory Syncytial Virus Infections
Pertussis toxin sensitization alters the pathogenesis of subsequent respiratory syncytial virus infection.
Respiratory Tract Infections
Pertussis toxin inhibits early chemokine production to delay neutrophil recruitment in response to Bordetella pertussis respiratory tract infection in mice.
Pertussis toxin permeabilization enhances the traversal of Escherichia coli K1, macrophages, and monocytes in a cerebral endothelial barrier model in vitro.
Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract.
Pseudomonas aeruginosa exoenzyme S as a pathogenic determinant in respiratory infections.
Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein.
[Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. I. Antibody level for B pertussis antigens in children without respiratory tract infection symptoms]
[The frequency of detection of IgA, IgG and IgM antibodies to pertussis toxin in patients with respiratory tract infections in Poland]
Retinal Degeneration
Drug repurposing studies of PARP inhibitors as a new therapy for inherited retinal degeneration.
Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse.
Fluorescent detection of PARP activity in unfixed tissue.
Intravitreal administration of adalimumab delays retinal degeneration in rd10 mice.
MUTYH promotes oxidative microglial activation and inherited retinal degeneration.
N -ethyl- N -nitrosourea induces retinal photoreceptor damage in adult rats.
Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration.
PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.
Photoreceptor cell death mechanisms in inherited retinal degeneration.
SIMULTANEOUS CELL DEATH AND UPREGULATION OF POLY(ADP-RIBOSE) POLYMERASE-1 (PARP-1) EXPRESSION IN EARLY POSTNATAL MOUSE RETINA.
Retinal Detachment
PJ34 Protects Photoreceptors from Cell Death by Inhibiting PARP-1 Induced Parthanatos after Experimental Retinal Detachment.
Retinal Diseases
Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse.
PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1?, Nrf2, and NF?B.
Poly(ADP-Ribose) Polymerase-1 inhibition potentiates cell death and phosphorylation of DNA damage response proteins in oxidative stressed retinal cells.
Retinal Dystrophies
Temporal progression of PARP activity in the Prph2 mutant rd2 mouse: Neuroprotective effects of the PARP inhibitor PJ34.
Retinitis Pigmentosa
Drug repurposing studies of PARP inhibitors as a new therapy for inherited retinal degeneration.
Efficacy of PARP inhibition in Pde6a mutant mouse models for retinitis pigmentosa depends on the quality and composition of individual human mutations.
Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation.
Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration.
Retinoblastoma
Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells.
Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners.
cAMP increasing agents attenuate the generation of apoptosis by etoposide in promonocytic leukemia cells.
Caspase-3 activation during the process of apoptosis induced by a vacuolar type H(+)-ATPase inhibitor.
Caspase-dependent activation of calpain during drug-induced apoptosis.
d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway.
Dysregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/MDA6 increases the susceptibility of human leukemia cells (U937) to 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial dysfunction and apoptosis.
Fas-mediated apoptosis in T cells involves the dephosphorylation of the retinoblastoma protein by type 1 protein phosphatases.
Histone deacetylase inhibitors valproic acid and depsipeptide sensitize retinoblastoma cells to radiotherapy by increasing H2AX phosphorylation and p53 acetylation-phosphorylation.
Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity (PSP).
Inhibitory effects of fenofibrate on apoptosis and cell proliferation in human endothelial cells in high glucose.
Interferon-lambda induces G1 phase arrest or apoptosis in oesophageal carcinoma cells and produces anti-tumour effects in combination with anti-cancer agents.
LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation.
Novel histone deacetylase inhibitors in the treatment of thyroid cancer.
p53-independent dephosphorylation and cleavage of retinoblastoma protein during tamoxifen-induced apoptosis in human breast carcinoma cells.
Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK.
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.
The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro.
Transcriptional down-regulation of poly(ADP-ribose) polymerase gene expression by E1A binding to pRb proteins protects murine keratinocytes from radiation-induced apoptosis.
Retinopathy of Prematurity
Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression.
Rhabdomyosarcoma
Differentiation of BA-HAN-1C rhabdomyosarcoma cells is controlled by a pertussis toxin sensitive signaling pathway.
Enhancement of Soft Tissue Sarcoma Cell Radiosensitivity by Poly(ADP-ribose) Polymerase-1 Inhibitors.
PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines.
Tyrosyl-DNA phosphodiesterase 1 (TDP1) and Poly (ADP-Ribose) Polymerase-1 (PARP1) deficiency are cytotoxic to rhabdomyosarcoma cells.
Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish.
Rhabdomyosarcoma, Alveolar
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Rhabdomyosarcoma, Embryonal
PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines.
Rheumatic Diseases
Identification of autoantibodies associated with systemic lupus erythematosus.
Rhinitis, Allergic
Investigation of poly (ADP-ribose) polymerase-1 genetic variants as a possible risk for allergic rhinitis.
Involvement of chemical mediators in nasal allergic responses of HDC-KO mice.
ring-type e3 ubiquitin transferase deficiency
BRCA1 deficiency and synthetic lethality in leukemias; not only gene mutation matters.
DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1.
Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality.
High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer.
Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer.
Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.
Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage.
rna-directed dna polymerase deficiency
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.
PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres.
Rubella
Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019.
Salmonella Infections
Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation.
Quantitative proteomic analysis of host epithelial cells infected by Salmonella enterica serovar Typhimurium.
Salmonella induces macrophage death by caspase-1-dependent necrosis.
Sarcoma
Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas.
Differential Sensitivity of Taxol-induced Apoptosis in U2OS and SaOS2 Osteogenic Sarcoma Cells.
Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression and its implication for PARP inhibitors in clinical trials.
Enhancement of Soft Tissue Sarcoma Cell Radiosensitivity by Poly(ADP-ribose) Polymerase-1 Inhibitors.
Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA.
IFN regulatory factor 8 sensitizes soft tissue sarcoma cells to death receptor-initiated apoptosis via repression of FLICE-like protein expression.
Individual and Combined Expression of DNA Damage Response Molecules PARP1, ?H2AX, BRCA1, and BRCA2 Predict Shorter Survival of Soft Tissue Sarcoma Patients.
MCM4 Is a Novel Biomarker Associated With Genomic Instability, BRCAness Phenotype, and Therapeutic Potentials in Soft-Tissue Sarcoma.
Molecular signatures of BRCAness analysis identifies PARP inhibitor Niraparib as a novel targeted therapeutic strategy for soft tissue Sarcomas.
Next-generation sequencing for the management of sarcomas with no known driver mutations.
PARP inhibition in UV-associated angiosarcoma preclinical models.
PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines.
PARP inhibitors: A new era of targeted therapy.
PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models.
PARP1 expression in soft tissue sarcomas is a poor-prognosis factor and a new potential therapeutic target.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Regulation of transmembrane signal transduction of insulin-like growth factor II by competence type growth factors or viral ras p21.
Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment.
SLFN11 is widely expressed in pediatric sarcoma and induces variable sensitization to replicative stress caused by DNA damaging agents.
Soft tissue sarcomas: new opportunity of treatment with PARP inhibitors?
The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage.
Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group.
Sarcoma, Ewing
Co-regulated expression of dbl and poly(ADP-ribose) polymerase in Ewing's sarcoma cells and dbl-transformed NIH3T3 fibroblasts.
Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma.
Combining poly(ADP-ribose) polymerase 1 (PARP-1) inhibition and radiation in Ewings sarcoma results in lethal DNA damage.
Constraints to DNA unwinding near radiation-induced strand breaks in Ewing's sarcoma cells.
Correction: The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin.
Current questions in bone sarcomas.
Differential regulation of the response to DNA damage in Ewing's sarcoma cells by ETS1 and EWS/FLI-1.
Ewing sarcoma protein promotes dissociation of poly(ADP-ribose) polymerase 1 from chromatin.
Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors.
EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.
EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma.
Expression of functional Y1 receptors for neuropeptide Y in human Ewing's sarcoma cell lines.
Expression of the human Bcl-2 increases resistance of Ewing's sarcoma cells to apoptosis and inhibits poly(ADP-ribose) polymerase cleavage induced by radiation.
Identification of a rearrangement in the 5' upstream region of the poly(ADP-ribose) polymerase pseudogene on chromosome 13 in Ewing's sarcoma cells.
Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing's sarcoma through the PI3K/Akt pathway.
Matrix screen identifies synergistic combination of PARP inhibitors and nicotinamide phosphoribosyltransferase (NAMPT) inhibitors in Ewing sarcoma.
Nanoformulation of Talazoparib Increases Maximum Tolerated Doses in Combination With Temozolomide for Treatment of Ewing Sarcoma.
New strategies in ewing sarcoma: lost in translation?
PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway.
PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma.
Phase 1/2 trial of talazoparib in combination with temozolomide in children and adolescents with refractory/recurrent solid tumors including Ewing sarcoma: A Children's Oncology Group Phase 1 Consortium study (ADVL1411).
Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy.
Poly(ADP-ribose) polymerase inhibitors in Ewing sarcoma.
Poly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells.
Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter.
Radiation-induced apoptosis of Ewing's sarcoma cells: DNA fragmentation and proteolysis of poly(ADP-ribose) polymerase.
Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells.
Regulation of the human poly(ADP-ribose) polymerase promoter by the ETS transcription factor.
Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells.
SARC025 arms 1 and 2: A phase 1 study of the poly(ADP-ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma.
SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing Sarcoma.
Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program.
Systematic identification of genomic markers of drug sensitivity in cancer cells.
The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity.
The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin.
Sarcoma, Synovial
Synovial sarcoma cell lines showed reduced DNA repair activity and sensitivity to a PARP inhibitor.
Sarcopenia
Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanism.
Scabies
Dynamics of Scabin toxin. A proposal for the binding mode of the DNA substrate.
Mapping the DNA-Binding Motif of Scabin Toxin, a Guanine Modifying Enzyme from Streptomyces scabies.
Scabin, a novel DNA-acting ADP-ribosyltransferase from Streptomyces scabies.
Scleroderma, Diffuse
Poly(ADP-ribose) polymerase activity in systemic lupus erythematosis and systemic sclerosis.
Scleroderma, Systemic
Calcinosis in Systemic Sclerosis: Updates in Pathophysiology, Evaluation, and Treatment.
Identification of autoantibodies associated with systemic lupus erythematosus.
PARP activity and NAD concentration in PMC from patients affected by systemic sclerosis and lupus erythematosus.
Poly(ADP-ribose) polymerase activity in systemic lupus erythematosis and systemic sclerosis.
Poly(ADP-ribose) polymerase-1 regulates fibroblast activation in systemic sclerosis.
Seizures
Death mechanisms in status epilepticus-generated neurons and effects of additional seizures on their survival.
Evidence for G protein modulation of experimental-generalized absence seizures in rat.
Intracerebroventricular pertussis toxin enhances sensitivity to chemical convulsants and decreases the protective efficacy of carbamazepine in mice.
Intracerebroventricular pertussis toxin enhances sensitivity to N-methyl-D-aspartate-induced seizures in mice.
Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases.
PARP1 activation/expression modulates regional-specific neuronal and glial responses to seizure in a hemodynamic-independent manner.
Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures.
Pertussis toxin decreases absence seizures and GABA(B) receptor binding in thalamus of a genetically prone rat (GAERS).
Pertussis toxin potentiates seizures induced by pilocarpine, kainic acid and N-methyl-D-aspartate.
Poly(ADP-ribose) polymerase inhibition protects epileptic hippocampal neurons from apoptosis via suppressing Akt-mediated apoptosis-inducing factor translocation in vitro.
Poly(ADP-ribose) polymerase inhibitor is neuroprotective in epileptic rat via apoptosis-inducing factor and Akt signaling.
Poly(ADP-ribose) signal in seizures-induced neuron death.
Regulation of hippocampal Fas receptor and death-inducing signaling complex after kainic acid treatment in mice.
Suppression of kindled seizure following intraamygdaloid injection of pertussis toxin in rats.
Sepsis
Differentiation-Associated Downregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Myoblasts Serves to Increase Their Resistance to Oxidative Stress.
Distinct fates of monocytes and T cells directly activated by Pseudomonas aeruginosa exoenzyme S.
ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury.
Inflammatory cytokines and lipopolysaccharide induce Fas-mediated apoptosis in renal tubular cells.
Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis.
Liposomal NAD(+) prevents diminished O(2) consumption by immunostimulated Caco-2 cells.
Local Administration of the Poly ADP-Ribose Polymerase (PARP) Inhibitor, PJ34 During Hindlimb Ischemia Modulates Skeletal Muscle Reperfusion Injury.
Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases.
PARP Inhibitors: An Innovative Approach to the Treatment of Inflammation and Metabolic Disorders in Sepsis.
Pneumonia-induced sepsis and gut injury: effects of a poly-(ADP-ribose) polymerase inhibitor.
Poly (ADP-ribose) polymerase activation and circulatory shock.
Poly (ADP-ribose) Polymerase1-Sirtuin1 functional interplay regulates LPS-mediated High Mobility Group Box-1 secretion.
Poly (ADP-ribose) synthetase inhibitor has a heart protective effect in a rat model of experimental sepsis.
Potential role of poly(adenosine 5'-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock.
Redox mechanisms of vascular cell dysfunction in sepsis.
Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis.
Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice.
Role of Exogenous Hsp72 on Liver Dysfunction during Sepsis.
Role of nitrosative stress and activation of poly(ADP-ribose) polymerase-1 in cardiovascular failure associated with septic and hemorrhagic shock.
Role of poly(adenosine diphosphate-ribose) polymerase 1 in septic peritonitis.
Temporally Distinct Regulation of Pathways Contributing to Cardiac Proteostasis During the Acute and Recovery Phases of Sepsis.
The decrease of PKCalpha is associated with hepatic apoptosis at early and late phases of polymicrobial sepsis.
The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis.
The parp-1 inhibitor ino-1001 facilitates hemodynamic stabilization without affecting DNA repair in porcine thoracic aortic cross-clamping-induced ischemia/reperfusion.
[Progress of nicotinamide in preventing infection and sepsis].
Sertoli Cell-Only Syndrome
Role of poly(ADP-ribosyl)ation during human spermatogenesis.
Severe Acute Respiratory Syndrome
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity.
Sezary Syndrome
Therapeutic and prognostic significance of PARP-1 in advanced mycosis fungoides and Sezary syndrome.
Shock, Septic
Association of poly(ADP-ribose) polymerase activity in circulating mononuclear cells with myocardial dysfunction in patients with septic shock.
Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia.
Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock.
Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase.
Increase of myocardial inhibitory G-proteins in catecholamine-refractory septic shock or in septic multiorgan failure.
Inhibition of PARP overactivation protects acute kidney injury of septic shock.
Poly (ADP-ribose) polymerase activation and circulatory shock.
Poly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator.
Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice.
Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice.
Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents.
The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function.
The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders.
The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis.
The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis.
Shwartzman Phenomenon
Cholera and pertussis exotoxins protect mice against the lethal Schwartzman reaction and antagonize the effects of lipopolysaccharide on second messenger systems.
Silicosis
Poly(ADP-ribosyl)ation in asthma and other lung diseases.
Sjogren's Syndrome
Identification of autoantibodies associated with systemic lupus erythematosus.
Skin Diseases
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.
Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin.
PARP14 limits severity of allergic skin disease.
Skin Neoplasms
Induction of apoptosis in A431 skin cancer cells by Cissus quadrangularis Linn stem extract by altering Bax-Bcl-2 ratio, release of cytochrome c from mitochondria and PARP cleavage.
PARP-1 protein expression in glioblastoma multiforme.
Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue.
Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types.
Sleep Apnea, Obstructive
The relationship between obstructive sleep apnea and intra-epidermal nerve fiber density, PARP activation and foot ulceration in patients with type 2 diabetes.
Small Cell Lung Carcinoma
A genetic snapshot of small cell lung cancer.
A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors.
Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer.
Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small cell lung cancer.
Correction to: The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer.
Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer.
Improved radiosynthesis of 123I-MAPi, an auger theranostic agent.
MiR-335 regulates the chemo-radioresistance of small cell lung cancer cells by targeting PARP-1.
MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer.
Nanoemulsion-Based Delivery of Fluorescent PARP Inhibitors in Mouse Models of Small Cell Lung Cancer.
PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer.
PARP inhibitors for small cell lung cancer and their potential for integration into current treatment approaches.
PARP Inhibitors: Extending Benefit Beyond BRCA Mutant Cancers.
Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer.
Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1.
The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer.
The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer.
The MYC Paralog-PARP1 Axis as a Potential Therapeutic Target in MYC Paralog-Activated Small Cell Lung Cancer.
The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors.
Veliparib in Combination with Carboplatin and Etoposide in Patients with Treatment-Naïve Extensive-Stage Small Cell Lung Cancer: A Phase 2 Randomized Study.
XPO1 inhibition synergizes with PARP1 inhibition in small cell lung cancer by targeting nuclear transport of FOXO3a.
Spermatic Cord Torsion
Inhibition of poly(adenosine diphosphate-ribose) polymerase decreases long-term histologic damage in testicular ischemia-reperfusion injury.
The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.
The efficiency of Poly(ADP-Ribose) Polymerase (PARP) cleavage on detection of apoptosis in an experimental model of testicular torsion.
Spinal Cord Compression
Apoptosis in human compressive myelopathy due to metastatic neoplasia.
Spinal Cord Injuries
3-aminobenzamide, one of poly(ADP-ribose)polymerase-1 inhibitors, rescuesapoptosisin rat models of spinal cord injury.
Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma.
Involvement of poly(ADP-ribose) polymerase-1 in development of spinal cord injury in Chinese individuals: a Chinese clinical study.
Nitric Oxide and Superoxide Anion Differentially Activate Poly(ADP-ribose) Polymerase-1 and Bax to Induce Nuclear Translocation of Apoptosis-Inducing Factor and Mitochondrial Release of Cytochrome c after Spinal Cord Injury.
Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro.
Poly(ADP-Ribose) polymerase-1 in acute neuronal death and inflammation: a strategy for neuroprotection.
Poly(ADP-ribosyl)ation enzyme-1 as a target for neuroprotection in acute central nervous system injury.
Role of ABT888, a Novel Poly(ADP-Ribose) Polymerase (PARP) Inhibitor in Countering Autophagy and Apoptotic Processes Associated to Spinal Cord Injury.
Role of free radicals and poly(ADP-ribose)polymerase-1 in the development of spinal cord injury: new potential therapeutic targets.
The selective poly(ADP)ribose-polymerase 1 inhibitor INO1001 reduces spinal cord injury during porcine aortic cross-clamping-induced ischemia/reperfusion injury.
Unusual increase in lumbar network excitability of the rat spinal cord evoked by the PARP-1 inhibitor PJ-34 through inhibition of glutamate uptake.
Squamous Cell Carcinoma of Head and Neck
A phase I trial adding poly(ADP-ribose) polymerase inhibitor veliparib to induction carboplatin-paclitaxel in patients with head and neck squamous cell carcinoma: Alliance A091101.
Abrogation of head and neck squamous cell carcinoma growth by epidermal growth factor receptor ligand fused to pseudomonas exotoxin transforming growth factor alpha-PE38.
Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers.
Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population.
Autophagy suppression enhances DNA damage and cell death upon treatment with PARP inhibitor Niraparib in laryngeal squamous cell carcinoma.
Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma.
Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models.
Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth.
DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma.
Dual disruption of DNA repair and telomere maintenance for the treatment of head and neck cancer.
Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells.
Effect of ethanol extracts of Antrodia cinnamomea on head and neck squamous cell carcinoma cell line.
Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma.
Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells.
Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling.
Novel C-Terminal Hsp90 Inhibitor for Head and Neck Squamous Cell Cancer (HNSCC) with in vivo Efficacy and Improved Toxicity Profiles Compared with Standard Agents.
Novel targeted therapies in head and neck cancer.
Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L.
Optical Imaging of PARP1 in Response to Radiation in Oral Squamous Cell Carcinoma.
Overexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP inhibition enhances radiotherapy of SMAD4 deficient human head and neck squamous cell carcinomas in experimental models.
PARP inhibitors in head and neck cancer: Molecular mechanisms, preclinical and clinical data.
PARP-1 inhibitors sensitize HNSCC cells to APR-246 by inactivation of thioredoxin reductase 1 (TrxR1) and promotion of ROS accumulation.
PARP1 and CASP3 gene expression in a patient with multiple head and neck squamous cell carcinoma and Parkinson disease.
PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response.
Poly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells.
Prevalence of DNA Repair Gene Mutations in Blood and Tumor Tissue and Impact on Prognosis and Treatment in HNSCC.
Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma.
Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo.
Targeted therapy in head and neck cancer.
Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints.
Targeting of ?1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells.
The inhibition of PARP but not EGFR results in the radiosensitization of HPV/p16-positive HNSCC cell lines.
The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma.
Xanthorrhizol Induces Apoptosis Through ROS-Mediated MAPK Activation in Human Oral Squamous Cell Carcinoma Cells and Inhibits DMBA-Induced Oral Carcinogenesis in Hamsters.
Starvation
A New Pathway Promotes Adaptation of Human Glioblastoma Cells to Glucose Starvation.
ADP-ribosylation, DNA repair, cell differentiation and cancer.
Cell death induced by serum deprivation in luteal cells involves the intrinsic pathway of apoptosis.
Cisplatin resistance coupled to enhanced sensitivity to metabolic interventions.
Cleavage of poly (ADP-ribose) polymerase-1 is involved in the process of porcine ovarian follicular atresia.
Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer.
Heart/Cardiac Muscle: Cocaine- and amphetamine-regulated transcript (CART) peptide as an in vivo regulator of cardiac function in Rana ridibunda frog.
Hepatitis B virus X gene differentially modulates cell cycle progression and apoptotic protein expression in hepatocyte versus hepatoma cell lines.
Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures.
PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2.
PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription.
Poly(ADP-Ribose) Polymerase-1 Mediates Angiotensin II-Induced Expression of Plasminogen Activator Inhibitor-1 and Fibronectin in Rat Mesangial Cells.
Prothymosin alpha and cell death mode switch, a novel target for the prevention of cerebral ischemia-induced damage.
ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy.
Signaling interplay between PARP1 and ROS regulates stress-induced cell death and developmental changes in Dictyostelium discoideum.
Status Epilepticus
Mitochondrial Dysfunction Mediated by Poly(ADP-Ribose) Polymerase-1 Activation Contributes to Hippocampal Neuronal Damage Following Status Epilepticus.
P2X7 receptor-mediated PARP1 activity regulates astroglial death in the rat hippocampus following status epilepticus.
PKC, AKT and ERK1/2-Mediated Modulations of PARP1, NF-?B and PEA15 Activities Distinctly Regulate Regional Specific Astroglial Responses Following Status Epilepticus.
Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors.
Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms.
Stomach Diseases
Helicobacter pylori activation of PARP-1: Usurping a versatile regulator of host cellular health.
Stomach Neoplasms
A mutational signature in gastric cancer suggests therapeutic strategies.
A novel compound, L34, induced apoptosis in human gastric cancer cells.
Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors.
ADPRT Val762Ala and XRCC1 Arg194Trp Polymorphisms and Risk of Gastric Cancer in Sichuan of China.
Allele-specific expression mediates primary resistance to poly (ADP-ribose) polymerase inhibitor therapy in a case of BRCA1/2 double-germline mutant gastric cancer.
Association between PSCA, TNF-?, PARP1 and TP53 Gene Polymorphisms and Gastric Cancer Susceptibility in the Brazilian Population.
ATM expression predicts Veliparib and Irinotecan sensitivity in gastric cancer by mediating P53 independent regulation of cell cycle and apoptosis.
CHFR regulates the mitotic checkpoint by targeting PARP-1 for ubiquitination and degradation.
Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer.
Cochinchina momordica seed extract induces apoptosis and cell cycle arrest in human gastric cancer cells via PARP and p53 signal pathways.
Combination of talaporfin photodynamic therapy and Poly (ADP-Ribose) polymerase (PARP) inhibitor in gastric cancer.
Combined treatment with PI3K inhibitor BKM120 and PARP inhibitor olaparib is effective in inhibiting the gastric cancer cells with ARID1A deficiency.
Complexity in the Gastric Cancer Genome and a Biomarker-Driven Trial of Poly (ADP-Ribose) Polymerase Inhibition in Gastric Cancer.
Deubiquitinylase USP47 Promotes RelA Phosphorylation and Survival in Gastric Cancer Cells.
Esculetin induces apoptosis in human gastric cancer cells through a cyclophilin D-mediated mitochondrial permeability transition pore associated with ROS.
Extract of Solanum muricatum (Pepino/CSG) inhibits tumor growth by inducing apoptosis.
Fas expression is downregulated in gastric cancer.
Functional long non-coding RNAs associated with gastric cancer susceptibility and evaluation of the epidemiological efficacy in a central Chinese population.
Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS.
High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer.
Identification and epidemiological evaluation of gastric cancer risk factors: based on a field synopsis and meta-analysis in Chinese population.
Immature colon carcinoma transcript-1 promotes proliferation of gastric cancer cells.
In silico identification of poly(ADP-ribose)polymerase-1 inhibitors and their chemosensitizing effects against cisplatin-resistant human gastric cancer cells.
Inhibition of c-MET increases the antitumour activity of PARP inhibitors in gastric cancer models.
Inhibition of CREPT restrains gastric cancer growth by regulation of cycle arrest, migration and apoptosis via ROS-regulated p53 pathway.
Inhibition of PARP1 activity enhances chemotherapeutic efficiency in cisplatin-resistant gastric cancer cells.
Knockdown of RNF6 inhibits gastric cancer cell growth by suppressing STAT3 signaling.
Lentivirus-mediated inhibition of USP39 suppresses the growth of gastric cancer cells via PARP activation.
LncRNA ZEB2-AS1 contributes to the tumorigenesis of gastric cancer via activating the Wnt/?-catenin pathway.
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.
Luteolin exerts a marked antitumor effect in cMet-overexpressing patient-derived tumor xenograft models of gastric cancer.
Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2.
Metformin inhibits gastric cancer via the inhibition of HIF1?/PKM2 signaling.
miR-106a Is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS.
MTA2 sensitizes gastric cancer cells to PARP inhibition by induction of DNA replication stress.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP inhibitors in gastric cancer: beacon of hope.
PARP inhibitors target ATM+p53-defective gastric cancer.
PARP-1 Val762Ala polymorphism, CagA(+) H. pylori infection and risk for gastric cancer in Han Chinese population.
PARP1 Polymorphisms Increase the Risk of Gastric Cancer in a Chinese Population.
PARP10 (ARTD10) modulates mitochondrial function.
PARP1: A potential biomarker for gastric cancer.
Polymorphisms of XRCC1 and ADPRT genes and risk of noncardia gastric cancer in a Chinese population: a case-control study.
Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer.
Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells.
Silencing of CHFR Sensitizes Gastric Carcinoma to PARP Inhibitor Treatment.
SOX2 inhibits cell proliferation and metastasis, promotes apoptotic by downregulating CCND1 and PARP in gastric cancer.
Tanshinone IIA inhibits gastric carcinoma AGS cells by decreasing the protein expression of VEGFR and blocking Ras/Raf/MEK/ERK pathway.
The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1.
Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications.
Tumor-suppressive effects of 1,25-dihydroxyvitamin D3 in gastric cancer cells.
Ultrafine particles of Ulmus davidiana var. japonica induce apoptosis of gastric cancer cells via activation of caspase and endoplasmic reticulum stress.
Variant of SNPs at lncRNA NEAT1 contributes to gastric cancer susceptibility in Chinese Han population.
What Will We Expect From Novel Therapies to Esophageal and Gastric Malignancies?
[Correlation of Genetic Polymorphisms in DNA Repair Genes ADPRT and XRCC1 to Risk of Gastric Cancer.]
Stomach Ulcer
The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat.
Stroke
A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats.
A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia.
A review on PARP1 inhibitors: Pharmacophore modeling, virtual and biological screening studies to identify novel PARP1 inhibitors.
Alternative mechanisms of inhibiting activity of poly (ADP-ribose) polymerase-1.
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase.
Anti-inflammatory mechanism of taurine against ischemic stroke is related to down-regulation of PARP and NF-?B.
Cell Death Mechanisms of Neurodegeneration.
Clinical perspectives of PARP inhibitors.
Combinatorial-approached neuroprotection using pan-caspase inhibitor and poly (ADP-ribose) polymerase (PARP) inhibitor following experimental stroke in rats; is there additional benefit?
Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia.
Delayed PARP-1 Inhibition Alleviates Post-stroke Inflammation in Male Versus Female Mice: Differences and Similarities.
Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors.
Development of a miniaturized assay for the high-throughput screening program for poly(ADP-ribose) polymerase-1.
Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia.
Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke.
Emerging role of PARP-1 and PARthanatos in ischemic stroke.
Evaluation of the poly(ADP-ribose) polymerase gene in human stroke.
Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death.
Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death.
Inhibition of poly(ADP-ribose) polymerase suppresses inflammation and promotes recovery after ischemic injury.
Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma.
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy.
Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.
Local Administration of the Poly ADP-Ribose Polymerase (PARP) Inhibitor, PJ34 During Hindlimb Ischemia Modulates Skeletal Muscle Reperfusion Injury.
Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase.
Mediation of cell death by poly(ADP-ribose) polymerase-1.
Mitochondrial dysfunction induced by nuclear poly(ADP-ribose) polymerase-1: a treatable cause of cell death in stroke.
Molecular targets in cerebral ischemia for developing novel therapeutics.
Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke.
Natural Inhibitors of Poly(ADP-ribose) Polymerase-1.
Neuronal caspase-3 and PARP-1 correlate differentially with apoptosis and necrosis in ischemic human stroke.
Nicotinamide offers multiple protective mechanisms in stroke as a precursor for NAD+, as a PARP inhibitor and by partial restoration of mitochondrial function.
Nicotinamide therapy protects against both necrosis and apoptosis in a stroke model.
Novel modulators of poly(ADP-ribose) polymerase.
Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke.
PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases.
PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery.
Parthanatos, a messenger of death.
Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure.
Pharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: future directions.
Poly (adp-ribose) polymerase inhibitors as potential therapeutic agents in stroke and neurotrauma.
Poly (ADP-ribose) polymerase, nitric oxide and cell death.
Poly (ADP-Ribose) Polymerase-1 (PARP-1) as Immune Regulator.
Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases.
Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors.
Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update.
Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery.
Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke.
Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Reduces Brain Damage after Stroke in the Neonatal Mouse Brain.
Poly(ADP-ribose) polymerase inhibitors.
Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications.
Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications.
Poly(ADP-ribose) polymerase-1 in the nervous system.
Poly(ADP-ribose) polymerase-1 inhibition increases expression of heat shock proteins and attenuates heat stroke-induced liver injury.
Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity.
Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications.
Poly(ADP-Ribose)Polymerase 1 (PARP-1) Activation and Ca(2+) Permeable ?-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Channels in Post-Ischemic Brain Damage: New Therapeutic Opportunities?
Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage.
Poly(ADP-ribose)polymerase inhibition - where now?
Polymorphism of PARP-1 indicates an increased risk and a worse initial severity of ischemic stroke.
Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment.
Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors.
Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice.
Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke.
Reduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in mice.
Regulatory T cells increase after treatment with poly (ADP-ribose) polymerase-1 inhibitor in ischemic stroke patients.
Role of Cytotoxic Protease Granzyme-b in Neuronal Degeneration during Human Stroke.
Sex differences in minocycline-induced neuroprotection after experimental stroke.
Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke.
Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke.
Sex Differences in the Response to Poly(ADP-ribose) Polymerase-1 Deletion and Caspase Inhibition After Stroke.
Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies.
Targeting Parthanatos in Ischemic Stroke.
The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function.
The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia.
The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis.
Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond.
[Gender-specific factors of ischemic stroke among atrial fibrillation patients].
Strongyloidiasis
The impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: Secondary analysis of a randomised controlled trial.
Subarachnoid Hemorrhage
Inhibition of poly(ADP-ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits.
PARP inhibition attenuates early brain injury through NF-?B/MMP-9 pathway in a rat model of subarachnoid hemorrhage.
Potential role of poly (ADP-ribose) polymerase in delayed cerebral vasospasm following subarachnoid hemorrhage in rats.
Sunburn
Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin.
superoxide dismutase deficiency
Role of Oxidative Stress and AT1 Receptors in Cerebral Vascular Dysfunction with Aging.
Synovitis
Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice.
Tachycardia
"Pertussis toxin induces tachycardia and impairs the increase in blood pressure produced by alpha 2-adrenergic agonists".
Effect of pertussis toxin on the heart muscarinic-cholinergic receptors and their function.
The effects of pertussis toxin on vasoconstrictor and vasodilator agents in the pithed rat may not be an indicator of G-protein receptor coupling.
Telangiectasis
Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells.
Concordance of ATM (Ataxia Telangiectasia Mutated) Immunohistochemistry between Biopsy or Metastatic Tumor Samples and Primary Tumors in Gastric Cancer Patients.
Loss of PIDD limits NF-?B activation and cytokine production but not cell survival or transformation after DNA damage.
Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors.
Teratocarcinoma
Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment.
Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells.
Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta.
Teratoma
PARP expression in germ cell tumours.
Teratozoospermia
Spermatid Head Elongation with Normal Nuclear Shaping Requires ADP-Ribosyltransferase PARP11 (ARTD11) in Mice.
Testicular Neoplasms
PARP expression in germ cell tumours.
Tetanus
A Belgian Serosurveillance/Seroprevalence Study of Diphtheria, Tetanus and Pertussis Using a Luminex xMAP Technology-Based Pentaplex.
A fully liquid DTaP-IPV-Hep B-PRP-T hexavalent vaccine for primary and booster vaccination of healthy Mexican children.
A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins.
A randomized controlled trial of two acellular pertussis-diphtheria-tetanus vaccines in primary immunization in Ghana: antibody responses and adverse reactions.
Acellular pertussis vaccine given by accelerated schedule: response of preterm infants.
Adequate tetanus but poor diphtheria and pertussis response to a Tdap booster in adolescents with juvenile systemic lupus erythematosus.
Adverse effects and sero-responses to an acellular pertussis/diphtheria/tetanus vaccine when combined with Haemophilus influenzae type b vaccine in an accelerated schedule.
Adverse reactions of a pertussis toxoid vaccine in a double-blind placebo-controlled trial.
Antibody persistence 2 and 3 years after booster vaccination of adolescents with recombinant acellular pertussis monovalent aPgen or combined TdaPgen vaccines.
Antibody response to diphtheria-tetanus-pertussis immunization in preterm infants who receive dexamethasone for chronic lung disease.
Antibody responses of healthy infants to concurrent administration of a bivalent haemophilus influenzae type b-hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines.
Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK.
Association of Routine Infant Vaccinations With Antibody Levels Among Preterm Infants.
Clinical reactions and immunogenicity of the BIKEN acellular diphtheria and tetanus toxoids and pertussis vaccine in 4- through 6-year-old US children.
Comparative safety and immunogenicity of an acellular versus whole-cell pertussis component of diphtheria-tetanus-pertussis vaccines in Senegalese infants.
Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine. The Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine.
Comparison of 13 acellular pertussis vaccines: overview and serologic response.
Comparison of a fifth dose of a five-component acellular or a whole cell pertussis vaccine in children four to six years of age.
Comparison of the safety and immunogenicity of acellular (BIKEN) and whole-cell pertussis vaccines in 15- to 20-month-old children.
Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China.
Development and validation of a multiplex immunoassay for the simultaneous determination of serum antibodies to Bordetella pertussis, diphtheria and tetanus.
Development and Validation of Magnetic Bead Pentaplex Immunoassay for Simultaneous Quantification of murine serum IgG antibodies to Acellular Pertussis, Diphtheria and Tetanus Antigens used in combination vaccines.
Diphtheria, tetanus and pertussis antibodies in 10-year-old children before and after a booster dose of three toxoids: implications for the timing of a booster dose.
Effect of combination with an acellular pertussis, diphtheria, tetanus vaccine on antibody response to Hib vaccine (PRP-T).
Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children.
Effect of local massage on vaccination: DTP and DTPa.
Effect of priming with diphtheria and tetanus toxoids combined with whole-cell pertussis vaccine or with acellular pertussis vaccine on the safety and immunogenicity of a booster dose of an acellular pertussis vaccine containing a genetically inactivated pertussis toxin in fifteen- to twenty-one-month-old children. Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine.
Enhanced post-licensure safety surveillance of a new recombinant acellular pertussis vaccine licensed as a monovalent (aP, Pertagen®) and tetanus, reduced-dose diphtheria combination (TdaP, Boostagen®) vaccine for immunization of adolescents and adults in Thailand.
Entrapping of impermeant probes of different size into nonpermeabilized synaptosomes as a method to study presynaptic mechanisms.
Evaluation of a guinea pig model to assess interference in the immunogenicity of different components of a combination vaccine comprising diphtheria, tetanus and acellular pertussis (DTaP) vaccine and haemophilus influenzae type b capsular polysaccharide conjugate vaccine.
Experience with monocomponent acellular pertussis combination vaccines for infants, children, adolescents and adults-A review of safety, immunogenicity, efficacy and effectiveness studies and 15 years of field experience.
Expression and purification of a trivalent pertussis toxin-diphtheria toxin-tetanus toxin fusion protein in Escherichia coli.
Extensive swelling after booster doses of acellular pertussis-tetanus-diphtheria vaccines.
Fast, antigen-saving multiplex immunoassay to determine levels and avidity of mouse serum antibodies to pertussis, diphtheria, and tetanus antigens.
Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccines.
Generation of plant-derived recombinant DTP subunit vaccine.
Humoral and cellular immune responses in mice immunized with recombinant Mycobacterium bovis Bacillus Calmette-Guérin producing a pertussis toxin-tetanus toxin hybrid protein.
Humoral immunity of dTap-IPV vaccine (REPEVAX(®)) administered one month after dT-IPV vaccine (REVAXIS(®)) in adults with unknown vaccination history.
Identification of peptides that mimic the pertussis toxin binding site on bovine fetuin.
Identifying long-term memory B-cells in vaccinated children despite waning antibody levels specific for Bordetella pertussis proteins.
Immune response to a Tdap booster in vertically HIV-infected adolescents.
Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015.
Immunogenicity and reactogenicity of a single dose of a diphtheria--tetanus--acellular pertussis component vaccine (DTaP) compared to a diphtheria--tetanus toxoid (Td) and a diphtheria toxoid vaccine (d) in adults.
Immunogenicity and reactogenicity of the component acellular pertussis vaccine produced by a combination of column purified pertussis toxin and filamentous haemagglutinin.
Immunogenicity and safety after booster vaccination of diphtheria, tetanus, and acellular pertussis in young adults: an open randomized controlled trial in Japan.
Immunogenicity and Safety of Monovalent Acellular Pertussis Vaccine at Birth: A Randomized Clinical Trial.
Immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type B conjugate vaccine (PRP-T) for primary and booster vaccinations.
Immunogenicity of combined diphtheria, tetanus, and pertussis vaccine given at 2, 3, and 4 months versus 3, 5, and 9 months of age.
Immunogenicity of primary DPT vaccination.
Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life.
Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium.
Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule.
Local reactions and IgE antibodies to pertussis toxin after acellular diphtheria-tetanus-pertussis immunization.
Measuring immunoglobulin g antibodies to tetanus toxin, diphtheria toxin, and pertussis toxin with single-antigen enzyme-linked immunosorbent assays and a bead-based multiplex assay.
Neutralizing antibodies and immunoprotection against pertussis and tetanus obtained by use of a recombinant pertussis toxin-tetanus toxin fusion protein.
On technological and immunological benefits of multivalent single-injection microsphere vaccines.
Optimization of rPDT fusion protein expression by Escherichia coli in pilot scale fermentation: a statistical experimental design approach.
Persistence of antibody after accelerated immunisation with diphtheria/tetanus/pertussis vaccine.
Pertussis toxin enhanced IgG1 and IgE responses to primary tetanus immunization are mediated by interleukin-4 and persist during secondary responses to tetanus alone.
Pertussis toxin-induced alterations of murine hepatic drug metabolism following administration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed.
Pertussis vaccination during pregnancy in Belgium: Follow-up of infants until 1 month after the fourth infant pertussis vaccination at 15 months of age.
Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study.
Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy.
Production of tumor necrosis factors alpha and beta by human mononuclear leukocytes stimulated with mitogens, bacteria, and malarial parasites.
Quantitative determination of bioactive proteins in diphtheria tetanus acellular pertussis (DTaP) vaccine by liquid chromatography tandem mass spectrometry.
Quartz crystal microbalance investigation of the interaction of bacterial toxins with ganglioside containing solid supported membranes.
Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women.
Regulatory factors that determine growth and phenotype of normal human melanocytes.
Safety and immunogenicity of a combined pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliovirus and Haemophilus influenzae type b-tetanus conjugate vaccine in infants, compared with a whole cell pertussis pentavalent vaccine.
Safety and immunogenicity of six acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fifth dose in four- to six-year-old children.
Seroprevalence and placental transportation of maternal antibodies specific for Neisseria meningitidis serogroup C, Haemophilus influenzae type B, diphtheria, tetanus, and pertussis.
Seroprevalence of antibodies against diphtheria, tetanus, and pertussis among healthy Thai adolescents.
Serum antibodies to diphtheria-tetanus-pertussis vaccine components in Argentine children.
Serum antibodies to the components of diphtheria-tetanus-pertussis vaccine in Polish children related to vaccination status.
Specific T cell deletion by transfected human monocytes expressing fas ligand and antigen.
Spotlight on Tdap? vaccine (Covaxis®) as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis: in children (aged ?4 years), adolescents, and adults.
Tdap booster to adolescents with juvenile idiopathic arthritis on and off anti-TNF agents is safe and immunogenic.
Tdap(5) vaccine (covaxis®): a review of its use as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis in children (aged ?4 years), adolescents, and adults.
The Effect of Maternal Pertussis Immunization on Infant Vaccine Responses to a Booster Pertussis-Containing Vaccine in Vietnam.
The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells.
The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines.
The use of microcalorimetry to characterize tetanus neurotoxin, pertussis toxin and filamentous haemagglutinin.
Validation of the toxin-binding inhibition (ToBI) test for the estimation of the potency of the tetanus toxoïd component in vaccines.
Waning vaccine immunity and vaccination responses in children treated for acute lymphoblastic leukemia: A Canadian Immunization Research Network Study.
[Induction of protective immunity for Bordetella pertussis by nasal inoculation of pertussis vaccine in mice]
[Seroepidemiological Studies on Pertussis, Diphtheria and Tetanus among Nursing Students Enrolled between 1994 and 2011 in the Kitakyushu District].
Thrombocytopenia
Avatrombopag Optimizes Response to Niraparib by Managing Thrombocytopenia Associated with Poly-ADP Ribose Polymerase (PARP) Inhibition in Ovarian Cancer and Breast Cancer: A Case Series.
Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials.
Haematologic toxicities with PARP inhibitors in cancer patients: an up-to-date meta-analysis of 29 randomized controlled trials.
Identifying the need to refine the potential patient risk factors for niraparib-induced thrombocytopenia.
PARP inhibitor treatment of advanced breast cancer beyond the BRCA-mutated type: a meta-analysis.
Pharmacological differentiation by pertussis toxin of the in vivo acute responses to fMLP and PAF in guinea-pig lungs.
Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials.
Thrombosis
[Endothelial dysfunction and atherosclerosis]
Thymoma
Advances in the use of PARP inhibitor therapy for breast cancer.
Effect of pertussis toxin and PGE2 on the functioning of the IL-2 promoter in interleukin-1 treated EL4.NOB-1 thymoma cells.
IL-1 stimulates a diverging signaling pathway in EL4 6.1 thymoma cells. IL-2 release, but not IL-2 receptor expression, is sensitive to pertussis toxin.
Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Thyroid Cancer, Papillary
LncRNA-SLC6A9-5:2: A potent sensitizer in 131I-resistant papillary thyroid carcinoma with PARP-1 induction.
Thyroid Carcinoma, Anaplastic
PARP inhibitor olaparib increases the oncolytic activity of dl922-947 in in vitro and in vivo model of anaplastic thyroid carcinoma.
Thyroid Neoplasms
Amifostine does not protect thyroid cancer cells in DNA damaging in vitro models.
Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP.
Association between polymorphisms in DNA base excision repair genes XRCC1, APE1, and ADPRT and differentiated thyroid carcinoma.
Computational modeling reveals MAP3K8 as mediator of resistance to vemurafenib in thyroid cancer stem cells.
Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line.
Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells.
Human sodium-iodide symporter (hNIS) gene expression is inhibited by a trans-active transcriptional repressor, NIS-repressor, containing PARP-1 in thyroid cancer cells.
Interaction among susceptibility genotypes of PARP1 SNPs in thyroid carcinoma.
LncRNA-SLC6A9-5:2: A potent sensitizer in 131I-resistant papillary thyroid carcinoma with PARP-1 induction.
Molecular mechanisms of the effects of low concentrations of taxol in anaplastic thyroid cancer cells.
Synergy between HDAC and PARP Inhibitors on Proliferation of a Human Anaplastic Thyroid Cancer-Derived Cell Line.
The PARP inhibitor PJ34 modifies proliferation, NIS expression and epigenetic marks in thyroid cancer cell lines.
Thyroiditis
Association of three SNPs in the PARP-1 gene with Hashimoto's thyroiditis.
Tics
Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest.
Torsades de Pointes
PARP inhibitor-induced torsades de pointes in long QT syndrome: a case report.
Tourette Syndrome
Association of poly(ADP-ribose) polymerase-1 polymorphism with Tourette syndrome.
Trauma, Nervous System
Poly(ADP-ribose) polymerase inhibitors.
Tremor
Induction of type 1 immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12.
Triple Negative Breast Neoplasms
A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer.
A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability.
A Phase 1 trial of the poly(ADP-ribose) polymerase inhibitor olaparib (AZD2281) in combination with the anti-angiogenic cediranib (AZD2171) in recurrent epithelial ovarian or triple-negative breast cancer.
ABC4 Consensus: First Latin American Meeting-Assessment, Comments, and Application of Its Recommendations.
Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in triple-negative breast cancer (BrighTNess): a randomised, phase 3 trial.
Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells.
Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer.
Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer.
Appraising iniparib, the PARP inhibitor that never was--what must we learn?
Association BRCA mutation status between BMN 673 (talazoparib), an oral PARP inhibitor, in triple-negative breast cancer.
Augmentation of the antitumor effects of PARP inhibitors in triple-negative breast cancer via degradation by hydrophobic tagging modulation.
BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression.
Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer.
Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor.
BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile.
BRCA Gene Mutations and Poly(ADP-Ribose) Polymerase Inhibitors in Triple-Negative Breast Cancer.
Can patients with metastatic breast cancer be cured after introduction of newer and more effective agents?
CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.
CHFR-mediated degradation of RNF126 confers sensitivity to PARP inhibitors in triple-negative breast cancer cells.
CMF revisited in the 21st century.
Co-targeting poly(ADP-ribose) polymerase (PARP) and histone deacetylase (HDAC) in triple-negative breast cancer: Higher synergism in BRCA mutated cells.
Combination of Olaparib and radiotherapy for triple negative breast cancer: preliminary results of the RADIOPARP phase I trial.
Combination of Olaparib with radiotherapy for triple-negative breast cancers: One-year toxicity report of the RADIOPARP Phase I trial.
Corrigendum to "Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization" [Nanomedicine 12 (3) (2016), 745-757].
Corrigendum: PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer.
Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer.
Current Issues of Targeted Therapy in Metastatic Triple-Negative Breast Cancer.
Current Status of Poly(ADP-ribose) Polymerase Inhibitors as Novel Therapeutic Agents for Triple-Negative Breast Cancer.
DDB2 depletion sensitizes triple-negative breast cancer cells to PARP inhibition by destabilizing Rad51.
Decreased miR-206 expression in BRCA1 wild-type triple-negative breast cancer cells after concomitant treatment with gemcitabine and a Poly(ADP-ribose) polymerase-1 inhibitor.
Defective repair of oxidative dna damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase.
Deglycosylation of PD-L1 by 2-deoxyglucose reverses PARP inhibitor-induced immunosuppression in triple-negative breast cancer.
Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors.
Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
Dextran-modified Quercetin-Cu(II)/hyaluronic acid nanomedicine with natural poly(ADP-ribose) polymerase inhibitor and dual targeting for programmed synthetic lethal therapy in triple-negative breast cancer.
Differential anti-proliferative activities of poly(ADP-ribose) polymerase (PARP) inhibitors in triple-negative breast cancer cells.
Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.
Discovery of novel PARP/PI3K dual inhibitors with high efficiency against BRCA-proficient triple negative breast cancer.
Doubling down on the PI3K-AKT-mTOR pathway enhances the antitumor efficacy of PARP inhibitor in triple negative breast cancer model beyond BRCA-ness.
Downregulation of miR-221-3p and upregulation of its target gene PARP1 are prognostic biomarkers for triple negative breast cancer patients and associated with poor prognosis.
E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer.
Effect of AR antagonist combined with PARP1 inhibitor on sporadic triple-negative breast cancer bearing AR expression and methylation-mediated BRCA1 dysfunction.
Efficacy and mechanism of the combination of PARP and CDK4/6 inhibitors in the treatment of triple-negative breast cancer.
Erratum to "Doubling Down on the PI3K-AKTmTOR Pathway Enhances the Antitumor Efficacy of PARP Inhibitor in Triple Negative Breast Cancer Model beyond BRCA-ness" [Neoplasia 16 (2014) 43-72].
Establishment and Characterization of a Brca1-/-, p53-/- Mouse Mammary Tumor Cell Line.
Expert Insights on Triple-Negative Breast Cancer: Preparing for the Next Wave of Treatments.
Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner.
Expression of potential biomarkers associated with homologous recombination repair in patients with ovarian or triple-negative breast cancer.
Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity.
Functional consequences of a rare missense BARD1 c.403G>A germline mutation identified in a triple-negative breast cancer patient.
Gallic acid and curcumin induce cytotoxicity and apoptosis in human breast cancer cell MDA-MB-231.
Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization.
H-Ferritin-nanocaged olaparib: a promising choice for both BRCA-mutated and sporadic triple negative breast cancer.
Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors.
Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells.
Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells.
HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells.
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer.
Immune Checkpoint and Poly(ADP-Ribose) Polymerase Inhibition for Recurrent Platinum-Resistant Ovarian and Metastatic Triple-Negative Breast Cancers.
Inducing Synthetic Lethality using PARP Inhibitors.
Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy.
Iniparib, a PARP1 inhibitor for the potential treatment of cancer, including triple-negative breast cancer.
INPP4B overexpression enhances the antitumor efficacy of PARP inhibitor AG014699 in MDA-MB-231 triple-negative breast cancer cells.
Integrating poly(ADP-ribose) polymerase (PARP) inhibitors in the treatment of early breast cancer.
Is there an epigenetic component underlying the resistance of triple-negative breast cancers to parp inhibitors?
Judy Garber on PARP Inhibitors for Triple-Negative Breast Cancer.
Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer.
Metallointercalator [Ru(dppz)2(PIP)]2+ Renders BRCA Wild-Type Triple-Negative Breast Cancer Cells Hypersensitive to PARP Inhibition.
Metformin reverses PARP inhibitors-induced epithelial-mesenchymal transition and PD-L1 upregulation in triple-negative breast cancer.
MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review.
Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells.
mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer.
MUC1-C Integrates Chromatin Remodeling and PARP1 Activity in the DNA Damage Response of Triple-Negative Breast Cancer Cells.
New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy.
New Perspectives for Resistance to PARP Inhibitors in Triple-Negative Breast Cancer.
New RAD51 Inhibitors to Target Homologous Recombination in Human Cells.
Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.
p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors.
Pan-cancer analysis of genomic scar signatures associated with homologous recombination deficiency suggests novel indications for existing cancer drugs.
PARP inhibitor and platinum agent in triple negative breast cancer: utilizing innovative trial design to bring together something "new" and something "old".
PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer.
PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer.
PARP Inhibitor Olaparib Use in a BRCA1-Positive Patient With Metastatic Triple-Negative Breast Cancer, Without the Initial Use of Platinum-Based Chemotherapy, Showing Significant Rapid Near Resolution of Large Liver Metastasis While Patient Experienced Gout-Like Symptoms.
PARP Inhibitors for the Treatment and Prevention of Breast Cancer.
PARP inhibitors in BRCA1-/BRCA2-associated and triple-negative breast cancers.
PARP Inhibitors in Breast Cancer.
PARP inhibitors in breast cancer: BRCA and beyond.
PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer.
PARP Inhibitors in Triple-Negative Breast Cancer Including Those With BRCA Mutations.
PARP1 and PRC2 double deficiency promotes BRCA-proficient breast cancer growth by modification of the tumor microenvironment.
PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow.
PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers.
Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer.
Phase I and pharmacokinetic study of veliparib, a PARP inhibitor, and pegylated liposomal doxorubicin (PLD) in recurrent gynecologic cancer and triple negative breast cancer with long-term follow-up.
Phase I Study of Veliparib (ABT-888) Combined with Cisplatin and Vinorelbine in Advanced Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer.
Phase I trial of the oral PARP inhibitor olaparib in combination with paclitaxel for first- or second-line treatment of patients with metastatic triple-negative breast cancer.
PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA proficient triple negative breast cancer to PARP inhibition.
Poly(ADP-Ribose) polymerase inhibition: "Targeted" therapy for triple-negative breast cancer.
Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer?
Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer.
Polymorphisms in PARP1 predict disease-free survival of triple-negative breast cancer patients treated with anthracycline/taxane based adjuvant chemotherapy.
Polymorphisms in poly (ADP-ribose) polymerase-1 (PARP1) promoter and 3' untranslated region and their association with PARP1 expression in breast cancer patients.
Prosopis juliflora (Sw.), DC induces apoptosis and cell cycle arrest in triple negative breast cancer cells: in vitro and in vivo investigations.
Protein expression of DNA damage repair proteins dictates response to topoisomerase and PARP inhibitors in triple-negative breast cancer.
Rad51 inhibition sensitizes breast cancer stem cells to PARP inhibitor in triple-negative breast cancer.
RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer.
Randomized phase II trial of cyclophosphamide and the oral poly (ADP-ribose) polymerase inhibitor veliparib in patients with recurrent, advanced triple-negative breast cancer.
Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.
Response of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition.
Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-Ribose) polymerase inhibition, gemcitabine, and cisplatin.
Synthetic lethal interactions between EGFR and PARP inhibition in human triple negative breast cancer cells.
Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells.
Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer.
Targeted therapy for breast cancer.
Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.
The cancer-testis gene, MEIOB, sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency.
The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer.
The role of PARP inhibition in triple-negative breast cancer: Unraveling the wide spectrum of synthetic lethality.
Therapeutic potential of PARP inhibitors for metastatic breast cancer.
Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer.
Translating the role of PARP inhibitors in triple-negative breast cancer.
Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor.
Triple-negative breast cancer and Poly(ADP-ribose) polymerase inhibitors.
Triple-negative breast cancer: molecular features, pathogenesis, treatment and current lines of research.
Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types.
Using multiple targeted therapies in oncology: considerations for use, and progress to date in breast cancer.
XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib.
Zebrafish Xenografts Unveil Sensitivity to Olaparib beyond BRCA Status.
[Effects of Olaparib, a PARP-1 Inhibitor, on Triple Negative Breast Cancer Cells with a BRCA1 Mutation].
[Effects of poly(ADP-ribose)polymerase inhibitor AG014699 combined with chemotherapy on the proliferation of triple-negative breast cancer cell line MDA-MB-231].
[PARP inhibitors--theoretical basis and clinical application].
[Triple-negative breast cancer: molecular characteristics and potential therapeutic approaches].
Tuberculosis
Early IFN-? production together with decreased expression of TLR3 and TLR9 characterizes EAE development conditional on the presence of myelin.
Evaluation of IL-17 Serum Level, Brain Inflammation and Demyelination in Experimental Autoimmune Encephalomyelitis C57BL/6 Mice Model with Different Doses of Myelin Oligodendrocyte Glycoprotein.
Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis.
Induction of polyclonal antibodies to the S1 subunit of pertussis toxin by synthetic peptides coupled to PPD: effect of conjugation method, adjuvant, priming and animal species.
Is rheumatoid arthritis a consequence of natural selection for enhanced tuberculosis resistance?
Mechanical hypernociception in experimental autoimmune encephalomyelitis.
Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis.
Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019.
Spontaneous induction of immunoregulation by an endogenous retinal antigen.
Titration of myelin oligodendrocyte glycoprotein (MOG) - Induced experimental autoimmune encephalomyelitis (EAE) model.
Use of type I and type IV hypersensitivity responses to define the immunopharmacological profile of drugs.
Typhoid Fever
Specific lung mucosal and systemic immune responses after oral immunization of mice with Salmonella typhimurium aroA, Salmonella typhi Ty21a, and invasive Escherichia coli expressing recombinant pertussis toxin S1 subunit.
Ureteral Obstruction
Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction.
Urinary Bladder Neoplasms
1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.
CD44 and RHAMM are essential for rapid growth of bladder cancer driven by loss of Glycogen Debranching Enzyme (AGL).
Chloroquine and hydroxychloroquine inhibit bladder cancer cell growth by targeting basal autophagy and enhancing apoptosis.
Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression.
Detection of Molecular Signatures of Homologous Recombination Deficiency in Bladder Cancer.
Genetic Variants of XRCC1, APE1, and ADPRT Genes and Risk of Bladder Cancer.
Genetic variation in the base excision repair pathway and bladder cancer risk.
Guggulsterone induces apoptosis and inhibits lysosomal-dependent migration in human bladder cancer cells.
Heptaphylline suppresses the proliferation and migration of human bladder cancer cells via induction of intrinsic apoptosis, autophagy and inhibition of ?-catenin signalling pathway.
High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility.
Immunomodulatory effects of recombinant BCG expressing pertussis toxin on TNF-alpha and IL-10 in a bladder cancer model.
In vitro Evidence of Human Immune Responsiveness Shows the Improved Potential of a Recombinant BCG Strain for Bladder Cancer Treatment.
Intravesical therapy with pertussis toxin before radical cystectomy in patients with bladder cancer: a Phase I study.
New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment.
Overexpression of immunoglobulin G prompts cell proliferation and inhibits cell apoptosis in human urothelial carcinoma.
Overexpression of PML induced apoptosis in bladder cancer cell by caspase dependent pathway.
PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53.
The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes.
The SMAD2/3 pathway is involved in hepaCAM-induced apoptosis by inhibiting the nuclear translocation of SMAD2/3 in bladder cancer cells.
[Knock-down of DAB2 interacting protein (DAB2IP) promotes proliferation and inhibits apoptosis of bladder cancer cells].
[The molecular mechanism of PML in inducing apoptosis of bladder cancer cell line]
Urinary Retention
PARP inhibition prevents oxidative injury of bladder induced by acute urinary retention and subsequent emptying.
Uterine Cervical Neoplasms
A phase I trial of paclitaxel, cisplatin, and veliparib in the treatment of persistent or recurrent carcinoma of the cervix: an NRG Oncology Study (NCT#01281852).
A Phase I-II Evaluation of Veliparib (NSC #737664), Topotecan, and Filgrastim or Pegfilgrastim in the Treatment of Persistent or Recurrent Carcinoma of the Uterine Cervix: An NRG Oncology/Gynecologic Oncology Group Study.
Atorvastatin suppresses the progression of cervical cancer via regulation of autophagy.
B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy.
Base excision repair pathway: PARP1 genotypes as modulators of therapy response in cervical cancer patients.
Bcl-2 confers survival in cisplatin treated cervical cancer cells: circumventing cisplatin dose-dependent toxicity and resistance.
Beyond Chemotherapy: An Overview and Review of Targeted Therapy in Cervical Cancer.
Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity.
Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria.
Complete pathological response to olaparib and bevacizumab in advanced cervical cancer following chemoradiation in a BRCA1 mutation carrier: a case report.
Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer.
Current Systemic Treatment Landscape of Advanced Gynecologic Malignancies.
Differential osmosensing signalling pathways and G-protein involvement in human cervical cells with different tumour potential.
Down-regulation of LHPP in cervical cancer influences cell proliferation, metastasis and apoptosis by modulating AKT.
Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9.
Expression of BAG-1 and PARP-1 in Precursor Lesions and Invasive Cervical Cancer Associated with Human Papillomavirus (HPV).
Expression of DNA damage response proteins in cervical cancer patients treated with radical chemoradiotherapy.
Gene Expression Analysis Identifies Novel Targets for Cervical Cancer Therapy.
Hazelnut (Corylus avellana L.) Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines.
Identification of Vaccinia-H1 Related Phosphatase as an Anticancer Target for 1,2,3,4,6-O-Pentagalloylglucose.
Immuno-related polymorphisms and cervical cancer risk: The IARC multicentric case-control study.
Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives.
Induction of apoptosis by the inhibitors of poly(ADP-ribose)polymerase in HeLa cells.
Interferon ? improves the efficacy of low dose cisplatin by inhibiting NF-?B/p-Akt signaling on HeLa cells.
Involvement of PARP-1 Val762Ala polymorphism in the onset of cervical cancer in caucasian women.
MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer.
MFAP5 suppression inhibits migration/invasion, regulates cell cycle and induces apoptosis via promoting ROS production in cervical cancer.
MicroRNA-7-5p Promotes Cisplatin Resistance of Cervical Cancer Cells and Modulation of Cellular Energy Homeostasis by Regulating the Expression of the PARP-1 and BCL2 Genes.
MiRNA-211 triggers an autophagy-dependent apoptosis in cervical cancer cells: regulation of Bcl-2.
MSX1 induces G0/G1 arrest and apoptosis by suppressing Notch signaling and is frequently methylated in cervical cancer.
Olaparib modulates DNA repair efficiency, sensitizes cervical cancer cells to cisplatin and exhibits anti-metastatic property.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
PARP-1 activity (PAR) determines the sensitivity of cervical cancer to olaparib.
PARP-1 inhibitor modulate ?-catenin signaling to enhance cisplatin sensitivity in cancer cervix.
PD-L1, PARP1, and MMRs as potential therapeutic biomarkers for neuroendocrine cervical cancer.
PI3K p110? inhibition sensitizes cervical cancer cells with aberrant PI3K signaling activation to PARP inhibitor BMN673.
Poly(ADP-Ribose) Polymerase in Cervical Cancer Pathogenesis: Mechanism and Potential Role for PARP Inhibitors.
Poly(ADP-ribose)polymerase1: A potential molecular marker to identify cancer during colposcopy procedures.
Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective.
Rational design and fabrication of a cancer-targeted chitosan nanocarrier to enhance selective cellular uptake and anticancer efficacy of selenocystine.
Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells.
RHCG suppresses cervical cancer progression through inhibiting migration and inducing apoptosis regulated by TGF-?1.
RNF114 suppresses metastasis through regulation of PARP10 in cervical cancer cells.
Rucaparib antagonize multidrug resistance in cervical cancer cells through blocking the function of ABC transporters.
Single nucleotide polymorphisms in DNA repair genes and risk of cervical cancer: A case-control study.
Structure-activity insights of harmine targeting DNA, ROS inducing cytotoxicity with PARP mediated apoptosis against cervical cancer, anti-biofilm formation and in vivo therapeutic study.
Synergistic interaction between tetra-arsenic oxide and paclitaxel in human cancer cells in vitro.
Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect.
Targeting cervical cancer: Is there a role for poly (ADP-ribose) polymerase inhibition?
The Anti-Proliferative Activity of the Hybrid TMS-TMF-4f Compound Against Human Cervical Cancer Involves Apoptosis Mediated by STAT3 Inactivation.
The poly (ADP-ribose) polymerase inhibitor rucaparib suppresses proliferation and serves as an effective radiosensitizer in cervical cancer.
The Role of PARP Inhibitors in the Treatment of Gynecologic Malignancies.
Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway.
Up-regulated lncRNA XIST contributes to progression of cervical cancer via regulating miR-140-5p and ORC1.
Uveitis
Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye.
Mycophenolate mofetil and cyclophosphamide treatments suppress inflammation intensity in an experimental model of autoimmune uveitis.
Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice.
Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals.
Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies.
The critical points in induction of experimental autoimmune uveitis.
Uveitis, Anterior
Experimental autoimmune anterior uveitis (EAAU). II. Dose-dependent induction and adoptive transfer using a melanin-bound antigen of the retinal pigment epithelium.
Vaccinia
Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction.
Molluscum contagiosum virus inhibitors of apoptosis: The MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein.
PARP-1 controls NK cell recruitment to the site of viral infection.
Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis.
Varicocele
Effects of varicocele upon the expression of apoptosis-related proteins.
Inhibition of poly(ADP-ribose) polymerase may have preventive potential for varicocoele-associated testicular damage in rats.
Potential Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Experimental Left Varicocele.
Varicose Veins
Expression of molecular mediators of apoptosis and their role in the pathogenesis of lower-extremity varicose veins.
Vascular Calcification
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2.
Vascular Diseases
Effect and mechanism of poly (ADP-ribose) polymerase-1 in aldosterone-induced apoptosis.
Hemorheological methods in drug research.
PARP-1 (Poly[ADP-Ribose] Polymerase 1) Inhibition Protects From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm in Mice.
The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia.
Vascular Ring
Enhanced G-protein-induced relaxation in portal hypertensive rats: role of nitric oxide.
Vascular System Injuries
Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation.
Poly(ADP-ribose) polymerase inhibitor PJ-34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest.
Vasospasm, Intracranial
Inhibition of poly(ADP-ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits.
Potential role of poly (ADP-ribose) polymerase in delayed cerebral vasospasm following subarachnoid hemorrhage in rats.
Ventilator-Induced Lung Injury
Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury.
The role of poly (ADP-ribose) polymerase in ventilator-induced lung injury.
Ventricular Premature Complexes
Mechanism of epinephrine-induced dysrhythmias in rat involves local cholinergic activation.
Vesicular Stomatitis
ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase ?-TrCP.
DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration.
Poly(ADP-ribose) polymerase 1 is not strictly required for infection of murine cells by retroviruses.
Virus Diseases
ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase ?-TrCP.
ARTC2.2/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets.
Caspase-mediated cleavage of adenovirus early region 1A proteins.
Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection.
Induction of apoptosis and cleavage of poly(ADP-ribose) polymerase by cytopathic bovine viral diarrhea virus infection.
Inhibition of PARP1 Dampens Pseudorabies Virus Infection through DNA Damage-Induced Antiviral Innate Immunity.
NAD+ Degrading Enzymes, Evidence for Roles During Infection.
NuMA and nuclear lamins are cleaved during viral infection--inhibition of caspase activity prevents cleavage and rescues HeLa cells from measles virus-induced but not from rhinovirus 1B-induced cell death.
PARP-1 controls NK cell recruitment to the site of viral infection.
PARP-1 mediated cell death is directly activated by ZIKV infection.
PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis.
Pertussis toxin sensitization alters the pathogenesis of subsequent respiratory syncytial virus infection.
Poly(ADP-ribose) polymerase activity in various U937 cell subclones with different susceptibility to HIV-1 infection: its dramatic decrease following persistent virus infection.
Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications.
Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration.
Rapid activation of poly(ADP-ribose) polymerase contributes to Sindbis virus and staurosporine-induced apoptotic cell death.
Reovirus transport--studies using lymphocytosis promoting factor.
Role of Poly(ADP-ribose) Polymerase (PARP1) in Viral Infection and its Implication in SARS-CoV-2 Pathogenesis.
SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection.
The potential association between PARP14 and SARS-CoV-2 infection (COVID-19).
Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections.
Wasting Syndrome
Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome.
Werner Syndrome
Ageing and PARP.
Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice.
Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1.
Identification of proteins in the hamster DNA end-binding complex.
In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.
Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.
Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.
Poly(ADP-ribosyl)ation, PARP, and aging.
Repair of telomeric DNA prior to replicative senescence.
The emerging role of poly(ADP-ribose) polymerase-1 in longevity.
Whooping Cough
"Antigonadal" activity of the neurohypophysial hormones in cultured rat testicular cells: abolition by pertussis toxin.
"Cleaved Lymphocytes" Could Be Induced by Pertussis Toxin Injection in Mice, and Are Actually Not Lymphocytes.
"Pertussis toxin induces tachycardia and impairs the increase in blood pressure produced by alpha 2-adrenergic agonists".
'Cross talk' between opioid peptide and adrenergic receptor signaling in isolated rat heart.
(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid attenuates N-methyl-D-aspartate-induced neuronal cell death in cortical cultures via a reduction in delayed Ca2+ accumulation.
(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced burst firing is mediated by a native pertussis toxin-sensitive metabotropic receptor at rat dorsolateral septal nucleus neurons.
(R)-methanandamide inhibits receptor-induced calcium responses by depleting internal calcium stores in cultured astrocytes.
-Myocardial protection by preconditioning. Experimental and clinical significance-.
1 alpha,25-dihydroxyvitamin D3-induced increments in hepatocyte cytosolic calcium and lysophosphatidylinositol: inhibition by pertussis toxin and 1 beta,25-dihydroxyvitamin D3.
1,25(OH)2-vitamin D-3 stimulates phospholipase A2 activity via a guanine nucleotide-binding protein in chick myoblasts.
1,25(OH)2-vitamin D3 stimulation of phospholipases C and D in muscle cells involves extracellular calcium and a pertussis-sensitive G protein.
1,25(OH)2D3 regulates protein kinase C activity through two phospholipid-dependent pathways involving phospholipase A2 and phospholipase C in growth zone chondrocytes.
1,25-dihydroxyvitamin D3 but not TPA activates PLD in Caco-2 cells via pp60(c-src) and RhoA.
1,25-dihydroxyvitamin D3 induces responsiveness to the chemotactic peptide f-Met-Leu-Phe in the human monocytic line U937: dissociation between calcium and oxidative metabolic responses.
1-Fluoro-2,4-dinitrobenzene and its derivatives act as secretagogues on rodent mast cells.
11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.
12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.
15-Hydroxyeicosatetraenoic acid (15-HETE) receptors. Involvement in the 15-HETE-induced stimulation of the cryptic 5-lipoxygenase in PT-18 mast/basophil cells.
17?-estradiol potentiates TREK1 channel activity through G protein-coupled estrogen receptor.
17Beta-estradiol inhibits high-voltage-activated calcium channel currents in rat sensory neurons via a non-genomic mechanism.
17beta-estradiol-mediated neuroprotection and ERK activation require a pertussis toxin-sensitive mechanism involving GRK2 and beta-arrestin-1.
1?,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-? phagocytosis and inflammation in Alzheimer's disease patients.
1alpha,25(OH)2D3 causes a rapid increase in phosphatidylinositol-specific PLC-beta activity via phospholipase A2-dependent production of lysophospholipid.
2-Arachidonoylglycerol enhances the phagocytosis of opsonized zymosan by HL-60 cells differentiated into macrophage-like cells.
2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism.
2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells.
2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils.
2-Arachidonylglyceryl ether and abnormal cannabidiol-induced vascular smooth muscle relaxation in rabbit pulmonary arteries via receptor-pertussis toxin sensitive G proteins-ERK1/2 signaling.
2-Azido-[32P]NAD+, a photoactivatable probe for G-protein structure: evidence for holotransducin oligomers in which the ADP-ribosylated carboxyl terminus of alpha interacts with both alpha and gamma subunits.
2-Chloroadenosine potentiates the alpha 1-adrenergic activation of phospholipase C through a mechanism involving arachidonic acid and glutamate in striatal astrocytes.
2-Chloroadenosine reduces the N calcium current of cultured mouse sensory neurones in a pertussis toxin-sensitive manner.
2-chloroadenosine stimulates granule exocytosis from mouse natural killer cells: evidence for signal transduction through a novel extracellular receptor.
2-methoxyestradiol binding of GPR30 down-regulates angiotensin AT(1) receptor.
24,25-(OH)2D3 regulates protein kinase C through two distinct phospholipid-dependent mechanisms.
27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages.
2[125I]Iodomelatonin binding and interaction with beta-adrenergic signaling in chick heart/coronary artery physiology.
3-Isobutyl-1-methylxanthine inhibits sustained calcium current independently of cyclic AMP in neuronal and endocrine cells.
3-Morpholinylsydnonimine inhibits glutamatergic transmission in rat rostral ventrolateral medulla via peroxynitrite formation and adenosine release.
36Cl- flux measurements on GABAA receptor-activated chloride exchange. Multiple mechanisms of the chloride channel inactivation.
3H-naloxone benzoylhydrazone binding in MOR-1-transfected Chinese hamster ovary cells: evidence for G-protein-dependent antagonist binding.
5'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes.
5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism.
5-Aminosalicylate stimulates phospholipase D activity in macrophages.
5-HT inhibits N-type but not L-type Ca(2+) channels via 5-HT1A receptors in lamprey spinal neurons.
5-HT potentiation of the GABA(A) response in the rat sacral dorsal commissural neurones.
5-HT receptors couple to activation of Akt, but not extracellular-regulated kinase (ERK), in cultured hippocampal neurons.
5-HT(7) receptors activate the mitogen activated protein kinase extracellular signal related kinase in cultured rat hippocampal neurons.
5-HT1A agonists induce central cholinergic antinociception.
5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools.
5-HT1A receptor activates Na+/H+ exchange in CHO-K1 cells through Gialpha2 and Gialpha3.
5-HT1A receptor-mediated activation of G-protein-gated inwardly rectifying K+ current in rat periaqueductal gray neurons.
5-HT1A receptor-mediated inhibition of acetylcholine release from guinea pig myenteric plexus: potential mechanisms.
5-HT1B receptor agonist CGS12066 presynaptically inhibits glutamate release in rat hippocampus.
5-HT1B Receptor-Mediated Activation of ERK1/2 Requires Both G?i/o and ?-Arrestin Proteins.
5-hydroxyicosatetraenoate stimulates neutrophils by a stereospecific, G protein-linked mechanism.
5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus.
5-Hydroxytryptamine 5-HT1D receptors mediating inhibition of cyclic AMP accumulation in Madin-Darby canine kidney (MDCK) cells.
5-hydroxytryptamine evokes endothelial nitric oxide synthase activation in bovine aortic endothelial cell cultures.
5-hydroxytryptamine induces mast cell adhesion and migration.
5-Hydroxytryptamine induces phospholipase C-mediated hydrolysis of phosphoinositides through 5-hydroxytryptamine-2 receptors in cultured fetal mouse ventricular myocytes.
5-Hydroxytryptamine receptor-mediated phosphoinositide hydrolysis in canine cultured tracheal smooth muscle cells.
5-Hydroxytryptamine-induced phosphoinositide hydrolysis and Ca2+ mobilisation in canine cultured aorta smooth muscle cells.
5-Hydroxytryptamine1-like receptors linked to increases in intracellular calcium concentration and inhibition of cyclic AMP accumulation in cultured vascular smooth muscle cells derived from bovine basilar artery.
5-Hydroxytryptamine1A receptor synthetic peptides. Mechanisms of adenylyl cyclase inhibition.
5-hydroxytryptamine1A receptor-mediated increases in receptor expression and activation of nuclear factor-kappaB in transfected Chinese hamster ovary cells.
5-Hydroxytryptamine1A receptors are linked to a Gi-adenylate cyclase complex in rat hippocampus.
5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation.
5-Methoxytryptamine inhibits cyclic AMP accumulation in cultured retinal neurons through activation of a pertussis toxin-sensitive site distinct from the 2-[125I]iodomelatonin binding site.
5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway.
5-Oxo-Eicosatetraenoic Acid-Induced Chemotaxis: Identification of a Responsible Receptor hGPCR48 and Negative Regulation by G Protein G12/13.
5-Oxo-ETE from Nasal Epithelial Cells Upregulates Eosinophil Cation Protein by Eosinophils in Nasal Polyps in vitro.
8-Iso-PGF2 alpha induces beta 2-integrin-mediated rapid adhesion of human polymorphonuclear neutrophils: a link between oxidative stress and ischemia/reperfusion injury.
?(2) -Adrenoceptors activate noradrenaline-mediated glycogen turnover in chick astrocytes.
?(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure.
?-1 Receptor Inhibition of ASIC1a Channels is Dependent on a Pertussis Toxin-Sensitive G-Protein and an AKAP150/Calcineurin Complex.
?-Arrestin Recruitment and G Protein Signaling by the Atypical Human Chemokine Decoy Receptor CCX-CKR.
?-Defensins activate human mast cells via Mas-related gene X2.
?-hydroxybutyrate and hydroxycarboxylic acid receptor 2 agonists activate the AKT, ERK and AMPK pathways, which are involved in bovine neutrophil chemotaxis.
?-Hydroxybutyric Acid Inhibits Growth Hormone-Releasing Hormone Synthesis and Secretion Through the GPR109A/Extracellular Signal-Regulated 1/2 Signalling Pathway in the Hypothalamus.
?-Hydroxybutyric Sodium Salt Inhibition of Growth Hormone and Prolactin Secretion via the cAMP/PKA/CREB and AMPK Signaling Pathways in Dairy Cow Anterior Pituitary Cells.
?-opioid receptor activation leads to neurite outgrowth and neuronal differentiation via a STAT5B-G?i/o pathway.
?-Opioid receptors stimulate the metabolic sensor AMP-activated protein kinase through coincident signaling with G(q/11)-coupled receptors.
?-Tetrahydrocannabinol induces cytotoxicity in macrophage J774-1 cells: involvement of cannabinoid receptor 2 and p38 MAPK.
?2-Adrenergic Disruption of ? Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling.
?2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation.
?2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling.
A 23-kilodalton protein, distinct from BvgA, expressed by virulent Bordetella pertussis binds to the promoter region of vir-regulated toxin genes.
A 43 kDa form of the GTP-binding protein Gi3 in human erythrocytes.
A 5-HT1-like receptor mediates a pertussis toxin-sensitive inhibition of rat ventromedial hypothalamic neurones in vitro.
A Belgian Serosurveillance/Seroprevalence Study of Diphtheria, Tetanus and Pertussis Using a Luminex xMAP Technology-Based Pentaplex.
A biased non-G?i OXE-R antagonist demonstrates that G?i protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE.
A binding motif for Hsp90 in the A chains of ADP-ribosylating toxins that move from the endoplasmic reticulum to the cytosol.
A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor.
A Bivalent Recombinant Mycobacterium bovis BCG Expressing the S1 Subunit of the Pertussis Toxin Induces a Polyfunctional CD4+ T Cell Immune Response.
A boarding school outbreak of pertussis in adolescents: value of laboratory diagnostic methods.
A Bordetella pertussis acellular vaccine candidate: antigenic characterization and antibody induction.
A C-terminally truncated human parathyroid hormone receptor is functional and activates multiple G proteins.
A cAMP independent inhibitory action of high doses of forskolin in rat Leydig cells.
A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis.
A chemoattractant-mediated Gi-coupled pathway activates adenylyl cyclase in human neutrophils.
A cholera toxin-sensitive G-protein stimulates exocytosis in sea urchin eggs.
A cholera toxin-sensitive guanyl nucleotide binding protein mediates the movement of pituitary luteinizing hormone into a releasable pool: loss of this event is associated with the onset of homologous desensitization to gonadotropin-releasing hormone.
A clonal rat pancreatic delta cell line (Rin14B) expresses a high number of galanin receptors negatively coupled to a pertussis-toxin-sensitive cAMP-production pathway.
A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors.
A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough.
A comparative analysis of B cell-mediated myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis pathogenesis in B cell-deficient mice reveals an effect on demyelination.
A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in rat Kupffer cells.
A comparative study of the role of adenylate cyclase in the release of adrenocorticotropin from the ovine and rat anterior pituitary.
A comparative trial of the reactogenicity and immunogenicity of Takeda acellular pertussis vaccine combined with tetanus and diphtheria toxoids. Outcome in 3- to 8-month-old infants, 9- to 23-month-old infants and children, and 24- to 30-month-old children.
A comparison of bradykinin, angiotensin II and muscarinic stimulation of cultured bovine adrenal chromaffin cells.
A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery.
A comparison of post-receptor signal transduction events in Jurkat cells transfected with either IL-8R1 or IL-8R2. Chemokine mediated activation of p42/p44 MAP-kinase (ERK-2).
A comparison of the ability of Leu8- and Pro8-oxytocin to regulate intracellular Ca2+ and Ca2+-activated K+ channels at human and marmoset oxytocin receptors.
A comparison of the antagonist affinities for the Gi- and Gs-coupled states of the human adenosine A1-receptor.
A comparison of the effects of concanavalin-A and tetradecanoylphorbol acetate on the modulation of parathyroid function by extracellular calcium and neomycin in dispersed bovine parathyroid cells.
A comparison of the effects of divalent and trivalent cations on parathyroid hormone release, 3',5'-cyclic-adenosine monophosphate accumulation, and the levels of inositol phosphates in bovine parathyroid cells.
A comparison of the effects of signal transduction inhibitors on oxidative burst and degranulation in IL-I beta stimulated bovine neutrophils.
A continuous, fluorescence-based assay of ?-opioid receptor activation in AtT-20 cells.
A controlled study of the relationship between Bordetella pertussis infections and sudden unexpected deaths among German infants.
A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group.
A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria-tetanus-pertussis vaccine.
A cross sectional survey measuring sero-incidence of pertussis infection among Japanese junior and senior high school students in 2013 and 2014.
A cross-sectional study of Bordetella pertussis seroprevalence and estimated duration of vaccine protection against pertussis in St. Petersburg, Russia.
A cysteine-3 to serine mutation of the G-protein Gi1 alpha abrogates functional activation by the alpha 2A-adrenoceptor but not interactions with the beta gamma complex.
A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats.
A deletion mutation in the third cytoplasmic loop of the mouse m1 muscarinic acetylcholine receptor unmasks cryptic G-protein binding sites.
A developmental role for the heterotrimeric G protein Go alpha in a migratory population of embryonic neurons.
A developmentally regulated switch in neuronal responsiveness to NCAM and N-cadherin in the rat hippocampus.
A diet enriched with cocoa prevents IgE synthesis in a rat allergy model.
A direct inhibitory action of prostaglandins upon ACTH secretion at the late stages of the secretory pathway of AtT-20 cells.
A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase.
A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.
A dopaminergic inhibitory postsynaptic potential mediated by an increased potassium conductance.
A dose-response study of forskolin, stimulatory hormone, and guanosine triphosphate analog on adenylate cyclase from several sources.
A DPDPE-induced enhancement of inward rectifier potassium current via opioid receptor in neuroblastomaxglioma NG108-15 cells.
A Drosophila melanogaster G protein alpha subunit gene is expressed primarily in embryos and pupae.
A dual role of protein kinase C in insulin signal transduction via adenylyl cyclase signaling system in muscle tissues of vertebrates and invertebrates.
A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: Regulation by pertussis toxin and PGE(2).
A fully liquid DTaP-IPV-Hep B-PRP-T hexavalent vaccine for primary and booster vaccination of healthy Mexican children.
A Functional and Neuropathological Testing Paradigm Reveals New Disability-Based Parameters and Histological Features for P0180-190-Induced Experimental Autoimmune Neuritis in C57BL/6 Mice.
A functional assay to measure postsynaptic gamma-aminobutyric acidB responses in cultured spinal cord neurons: heterologous regulation of the same K+ channel.
A functional C5a anaphylatoxin receptor in a teleost species.
A G protein beta gamma dimer-mediated pathway contributes to mitogen-activated protein kinase activation by thyrotropin-releasing hormone receptors in transfected COS-7 cells.
A G protein couples serotonin and GABAB receptors to the same channels in hippocampus.
A G Protein Mediates the Inhibition of the Voltage-Dependent Potassium M Current by Muscarine, LHRH, Substance P and UTP in Bullfrog Sympathetic Neurons.
A G protein-associated ERK pathway is involved in LPS-induced proliferation and a PTK-associated p38 MAPK pathway is involved in LPS-induced differentiation in resting B cells.
A G protein-coupled ?7 nicotinic receptor regulates signaling and TNF-? release in microglia.
A Galphas protein-coupled membrane receptor, distinct from the classical oestrogen receptor, transduces rapid effects of oestradiol on [Ca2+]i in female rat distal colon.
A General Lack of IgG Against Pertussis Toxin in Chinese Pregnant Women and Newborns.
A genetically inactivated two-component acellular pertussis vaccine, alone or combined with tetanus and reduced-dose diphtheria vaccines, in adolescents: a phase 2/3, randomised controlled non-inferiority trial.
A Go-like protein in Drosophila melanogaster and its expression in memory mutants.
A Gq-type G protein couples muscarinic receptors to inositol phosphate and calcium signaling in exocrine cells from the avian salt gland.
A GTP-binding protein activates chloride channels in a renal epithelium.
A GTP-binding protein in rat liver nuclei serving as the specific substrate of pertussis toxin-catalyzed ADP-ribosylation.
A guanine nucleotide regulatory protein controls polyphosphoinositide metabolism, Ca2+ mobilization, and cellular responses to chemoattractants in human monocytes.
A guanine nucleotide-binding protein mediates 1,25-dihydroxy-vitamin D-3-dependent rapid stimulation of Ca2+ uptake in skeletal muscle.
A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line.
A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium currents by dopamine in rat lactotrophs.
A guanine nucleotide-binding regulatory protein in human sperm mediates acrosomal exocytosis induced by the human zona pellucida.
A heterotrimeric G protein of the Gi family is required for cAMP-triggered trafficking of aquaporin 2 in kidney epithelial cells.
A heterotrimeric G protein, G alpha i-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells.
A heterotrimeric G protein-phospholipase A2 signaling cascade is involved in the regulation of peroxisomal motility in CHO cells.
A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29.
A high seroprevalence of antibodies to pertussis toxin among Japanese adults: Qualitative and quantitative analyses.
A high-affinity bradykinin receptor in membranes from rat myometrium is coupled to pertussis toxin-sensitive G-proteins of the Gi family.
A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor.
A knockout mutation of a constitutive GPCR in Tetrahymena decreases both G-protein activity and chemoattraction.
A label-free impedance-based whole cell assay revealed a new G protein-coupled receptor ligand for mouse microglial cell migration.
A leading role for NADPH oxidase in an in-vitro study of experimental autoimmune encephalomyelitis.
A lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation.
A mastoparan analog without lytic effects and its stimulatory mechanisms in mast cells.
A mechanism additional to cyclic AMP accumulation for vasoactive intestinal peptide-induced prolactin release.
A mechanism of action for anaphylatoxin C3a stimulation of mast cells.
A mechanistic approach into a diabetic serum factor-mediated release of beta-glucuronidase in normal neutrophils.
A membrane-delimited pathway of G-protein regulation of the guard-cell inward K+ channel.
A metabotropic L-glutamate receptor agonist: pharmacological difference between rat central neurones and crayfish neuromuscular junctions.
A model for the interaction of muscarinic receptors, agonists, and two distinct effector substances.
A modified vaccine reduces the rate of large injection site reactions to the preschool booster dose of diphtheria-tetanus-acellular pertussis vaccine: results of a randomized, controlled trial.
A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates.
A monoclonal anti-idiotypic antibody to opioid receptors labels desipramine-induced opioid binding sites on rat C6 glioma cells and attenuates thymidine incorporation into DNA.
A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins.
A nasal whole-cell pertussis vaccine induces specific systemic and cross-reactive mucosal antibody responses in human volunteers.
A neuroactive steroid inhibits guinea pig airway sensory nerves via Maxi-K channel activation.
A neutrophil GTP-binding protein that regulates cell free NADPH oxidase activation is located in the cytosolic fraction.
A new assay for invasion of HeLa 229 cells by Bordetella pertussis: effects of inhibitors, phenotypic modulation, and genetic alterations.
A new EAE model of brain demyelination induced by intracerebroventricular pertussis toxin.
A New Electrochemiluminescence-Based Multiplex Assay for the Assessment of Human Antibody Responses to Bordetella pertussis Vaccines.
A New Generation of FRET Sensors for Robust Measurement of G?i1, G?i2 and G?i3 Activation Kinetics in Single Cells.
A new GTP-binding protein in brain tissues serving as the specific substrate of islet-activating protein, pertussis toxin.
A new GTP-binding protein in differentiated human leukemic (HL-60) cells serving as the specific substrate of islet-activating protein, pertussis toxin.
A new lipophilic amino alcohol, chemically similar to compound FTY720, attenuates the pathogenesis of experimental autoimmune encephalomyelitis by PI3K/Akt pathway inhibition.
A new potassium ion current induced by stimulation of M2-cholinoreceptors in fish atrial myocytes.
A newly identified peptide, proadrenomedullin N-terminal 20 peptide, induces hypotensive action via pertussis toxin-sensitive mechanisms.
A newly synthesized molecule derived from ruthenium cation, with antitumour activity, activates NADPH oxidase in human neutrophils.
A non-inactivating K+ current sensitive to muscarinic receptor activation in rat cultured cerebellar granule neurons.
A novel action of collapsin: collapsin-1 increases antero- and retrograde axoplasmic transport independently of growth cone collapse.
A novel action of palmitoyl-L-carnitine in human vascular endothelial cells.
A novel approach to detect toxin-catalyzed ADP-ribosylation in intact cells: its use to study the action of Pasteurella multocida toxin.
A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion.
A novel bivalent acellular pertussis vaccine based on the 69 kDa protein and FHA.
A novel calcium signalling response in the breast cancer cell line MDA-468.
A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons.
A novel cardioprotective role of RhoA: new signaling mechanism for adenosine.
A novel cholera toxin-sensitive G-protein (Gc) regulating receptor-mediated phosphoinositide signalling in human pituitary clonal cells.
A novel collagen-binding peptide promotes osteogenic differentiation via Ca(2+)/calmodulin-dependent protein kinase II/ERK/AP-1 signaling pathway in human bone marrow-derived mesenchymal stem cells.
A novel extracellular nucleotide receptor coupled to phosphoinositidase-C in pituitary cells.
A novel function of sphingosine-1-phosphate to activate a non-selective cation channel in human endothelial cells.
A novel G protein alpha subunit containing atypical guanine nucleotide-binding domains is differentially expressed in a molluscan nervous system.
A novel G protein alpha subunit in embryo of the ascidian, Halocynthia roretzi.
A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. II. Purification, characterization, and reconstitution.
A novel hypothalamic peptide, pituitary adenylate cyclase activating peptide, modulates Sertoli cell function in vitro.
A novel mechanism for coupling of m4 muscarinic acetylcholine receptors to calmodulin-sensitive adenylyl cyclases: crossover from G protein-coupled inhibition to stimulation.
A novel mechanism for the inhibition of adenylate cyclase via inhibitory GTP-binding proteins. Calmodulin-dependent inhibition of the cyclase catalyst by the beta gamma-subunits of GTP-binding proteins.
A novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced increase in cytosolic Ca2+.
A novel mechanism of action of corticotropin releasing factor in rat Leydig cells.
A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes.
A novel method for the extraction of outer membrane vesicles (OMVs) from Bordetella pertussis Tohama strain.
A novel nonpeptide ligand for formyl peptide receptor-like 1.
A Novel Nutrient Sensing Mechanism Underlies Substrate-induced Regulation of Monocarboxylate Transporter 1.
A novel P2-purinoceptor expressed by a subpopulation of astrocytes from the dorsal spinal cord of the rat.
A novel pathway for receptor-mediated post-translational activation of inducible nitric oxide synthase.
A novel process for preparing an acellular pertussis vaccine composed of non-pyrogenic toxoids of pertussis toxin and filamentous hemagglutinin.
A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells.
A novel role for protein phosphatase 2A in receptor-mediated regulation of the cardiac sarcolemmal Na+/H+ exchanger NHE1.
A Novel Role for Somatostatin in the Survival of Mouse Pancreatic Beta Cells.
A novel role for testicular descent; temperature-dependent induction of pertussis toxin-sensitive Gi protein function in postnatal rat Leydig cells.
A novel signaling pathway for beta-adrenergic receptor-mediated activation of phosphoinositide 3-kinase in H9c2 cardiomyocytes.
A novel site of action of a high affinity A1 adenosine receptor antagonist.
A novel strategy to engineer functional fluorescent inhibitory G-protein alpha subunits.
A novel synergistic stimulation of Swiss 3T3 cells by extracellular ATP and mitogens with opposite effects on cAMP levels.
A P2 purinoceptor activated by ADP in rat medullar neurons.
A permissive role of pertussis toxin substrate G-protein in P2-purinergic stimulation of phosphoinositide turnover and arachidonate release in FRTL-5 thyroid cells. Cooperative mechanism of signal transduction systems.
A pertussis toxin resistant alpha 2-adrenoceptor pathway in fish melanophores.
A pertussis toxin sensitive G-protein-independent pathway is involved in serum amyloid A-induced formyl peptide receptor 2-mediated CCL2 production.
A pertussis toxin substrate regulates alpha 1-adrenergic dependent phosphatidylinositol hydrolysis in cultured rat myocytes.
A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line.
A pertussis toxin-sensitive 8-lipoxygenase pathway is activated by a nicotinic acetylcholine receptor in aplysia neurons.
A pertussis toxin-sensitive G protein in hippocampal long-term potentiation.
A pertussis toxin-sensitive G protein is required to induce histamine release from rat peritoneal mast cells by bradykinin.
A pertussis toxin-sensitive G protein mediates inhibition by morphine of spontaneous electrical activity of oxytocin neurones in anaesthetized rats.
A pertussis toxin-sensitive G-protein mediates some aspects of insulin action in BC3H-1 murine myocytes.
A pertussis toxin-sensitive G-protein mediates the alpha 2-adrenergic receptor inhibition of melatonin release in photoreceptive chick pineal cell cultures.
A pertussis toxin-sensitive GTP-binding protein couples endothelin to phospholipase C in rat mesangial cells.
A pertussis toxin-sensitive GTP-binding protein in the human neutrophil regulates multiple receptors, calcium mobilization, and lectin-induced capping.
A pertussis toxin-sensitive GTP-binding protein plays a role in the G0-G1 transition of rat hepatocytes following establishment in primary culture.
A pertussis toxin-sensitive mechanism of endothelin action in porcine coronary artery smooth muscle.
A pertussis toxin-sensitive process controls thymocyte emigration.
A pertussis-toxin-sensitive protein controls exocytosis in chromaffin cells at a step distal to the generation of second messengers.
A pertussis/cholera toxin sensitive G-protein may mediate vasopressin-induced inositol phosphate formation in smooth muscle cell.
A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction.
A pharmacological characterization of the mGluR1 alpha subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line.
A pharmacological investigation of the contribution of muscarinic receptor-linked potassium channels to the reversal by carbachol of positive inotropic responses of rabbit left atrium to cyclic AMP-generating agents.
A phase I, randomized, controlled, dose-ranging study of investigational acellular pertussis (aP) and reduced tetanus-diphtheria-acellular pertussis (TdaP) booster vaccines in adults.
A phase variant of Bordetella pertussis with a mutation in a new locus involved in the regulation of pertussis toxin and adenylate cyclase toxin expression.
A phorbol ester augments cAMP content and adenylyl cyclase activity in neonatal rat cardiac myocytes despite reduced beta adrenoceptor density.
A placebo-controlled trial of a pertussis-toxoid vaccine.
A pore-forming toxin produced by Aeromonas sobria activates Ca2+ dependent Cl- secretion.
A potassium conductance contributes to the action of somatostatin-14 to suppress ACTH secretion.
A potential role for guanine nucleotide-binding protein in the regulation of endosomal proton transport.
A predominant role for inhibition of the adenylate cyclase/protein kinase A pathway in ERK activation by cannabinoid receptor 1 in N1E-115 neuroblastoma cells.
A presynaptic action of the neurosteroid pregnenolone sulfate on GABAergic synaptic transmission.
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
A proposed mechanism of ADP-ribosylation catalyzed by the pertussis toxin S1 subunit.
A prostaglandin E receptor coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rabbit cortical collecting tubule cells.
A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils.
A proteoliposome formulation derived from Bordetella pertussis induces protection in two murine challenge models.
A quantitative analysis for the ADP-ribosylation activity of pertussis toxin: an enzymatic-HPLC coupled assay applicable to formulated whole cell and acellular pertussis vaccine products.
A randomised controlled trial with a diphtheria-tetanus-acellular pertussis (dTpa) vaccine in adults.
A randomized comparison of reactogenicity and immunogenicity of two whole-cell pertussis vaccines.
A randomized controlled trial of two acellular pertussis-diphtheria-tetanus vaccines in primary immunization in Ghana: antibody responses and adverse reactions.
A Randomized, Controlled Study of DTaP-IPV-HB-PRP-T, a Fully Liquid Hexavalent Vaccine, Administered in a 3-, 5- and 11- to 12-month Schedule.
A rapid ELISA-based method for screening Bordetella pertussis strain production of antigens included in current acellular pertussis vaccines.
A rapid, nongenomic action of glucocorticoids in rat B103 neuroblastoma cells.
A Real Time Chemotaxis Assay Unveils Unique Migratory Profiles amongst Different Primary Murine Macrophages.
A Real-Time, Fluorescence-Based Assay for Measuring ?-Opioid Receptor Modulation of Adenylyl Cyclase Activity in Chinese Hamster Ovary Cells.
A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins.
A region of the third intracellular loop of the short form of the D2 dopamine receptor dictates Gi coupling specificity.
A role for a pertussis toxin-sensitive trimeric G-protein in store-operated Ca2+ inflow in hepatocytes.
A role for extracellular calcium in the regulation of placental lactogen release by angiotensin-II and dopamine in human term trophoblastic cells.
A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells.
A role for heterotrimeric GTP-binding proteins and ERK1/2 in insulin-mediated, nitric-oxide-dependent, cyclic GMP production in human umbilical vein endothelial cells.
A role for M2 and M3 muscarinic receptors in the contraction of rat and human small airways.
A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT.
A role for the human sperm glycine receptor/Cl(-) channel in the acrosome reaction initiated by recombinant ZP3.
A role of protein kinase C mu in signalling from the human adenosine A1 receptor to the nucleus.
A role of the B-oligomer moiety of islet-activating protein, pertussis toxin, in development of the biological effects on intact cells.
A safety and immunogenicity comparison of 12 acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fourth dose in 15- to 20-month-old children.
A search for serologic correlates of immunity to Bordetella pertussis cough illnesses.
A semi-synthetic glycoconjugate antigen prepared by chemical glycosilation of pertussis toxin by a meningococcal group C oligosaccharide hapten.
A sensitive chemiluminescence assay for pertussis toxin and for evaluation of cell-free pertussis toxoids.
A sensitive method for measuring neutralizing antibodies to Bordetella pertussis toxin: optimized ADP-ribosylation of transducin.
A sex difference in the effect of prostaglandins on hormone-stimulated glycogenolysis in primary cultures of rat hepatocytes.
A signaling pathway for stimulation of Na+ uptake induced by angiotensin II in primary cultured rabbit renal proximal tubule cells.
A simple and sensitive ELISA of antibodies to pertussis antigens.
A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments.
A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis.
A single species of A1 adenosine receptor expressed in Chinese hamster ovary cells not only inhibits cAMP accumulation but also stimulates phospholipase C and arachidonate release.
A slowly ADP-ribosylated pertussis-toxin-sensitive GTP-binding regulatory protein is required for vasopressin-stimulated Ca2+ inflow in hepatocytes.
A somatostatin receptor inhibits noradrenaline release from chick sympathetic neurons through pertussis toxin-sensitive mechanisms: comparison with the action of alpha 2-adrenoceptors.
A specific beta gamma-subunit of transducin stimulates ADP-ribosylation of the alpha-subunit by pertussis toxin.
A spectroscopic and conformational study of pertussis toxin.
A step sensitive to pertussis toxin and phorbol ester in human neutrophils regulates chemotaxis and capping but not phagocytosis.
A study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal rats.
A subtype of kappa-opioid receptor mediates inhibition of high-affinity GTPase inherent in Gi1 in guinea pig cerebellar membranes.
A synthetic decapeptide from a conserved ZP3 protein domain induces the G protein-regulated acrosome reaction in bovine spermatozoa.
A ten year follow-up after immunization with a two component acellular pertussis vaccine.
A threshold level of coupled G-proteins is required to transduce neutrophil responses.
A trace component of ginseng that inhibits Ca2+ channels through a pertussis toxin-sensitive G protein.
A transduction pathway associated with receptors coupled to the inhibitory guanine nucleotide binding protein Gi that amplifies ATP-mediated arachidonic acid release.
A truncated form of CKbeta8-1 is a potent agonist for human formyl peptide-receptor-like 1 receptor.
A truncated recombinant alpha subunit of Gi3 with a reduced affinity for beta gamma dimers and altered guanosine 5'-3-O-(thio)triphosphate binding.
A two-dimensional model of cell movement. Well differentiated human rectal adenocarcinoma cells move as coherent sheets upon TPA stimulation.
A two-phase within-host model for immune response and its application to serological profiles of pertussis.
A two-step mechanism by which corticotropin-releasing hormone releases hypothalamic beta-endorphin: the role of vasopressin and G-proteins.
A tyrosine kinase regulates alpha-adrenoceptor-stimulated contraction and phospholipase D activation in the rat aorta.
A unique sequence of the Bordetella pertussis toxin operon.
A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.
A versatile, non genetically modified organism (GMO)-based strategy for controlling low-producer mutants in Bordetella pertussis cultures using antigenic modulation.
A voltage-independent calcium current inhibitory pathway activated by muscarinic agonists in rat sympathetic neurons requires both Galpha q/11 and Gbeta gamma.
A voltage-independent K+ conductance activated by cell swelling in Ehrlich cells is modulated by a G-protein-mediated process.
A WB 4101-sensitive alpha-1 adrenergic receptor subtype modulates repolarization in canine Purkinje fibers.
A(2B) adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin.
A-type potassium current modulated by A1 adenosine receptor in frog melanotrophs.
A1 Adenosine Receptor Modulation of Adenylyl Cyclase of a Deep-living Teleost Fish, Antimora rostrata.
A1 adenosine receptor-mediated Ins(1,4,5)P3 generation in allergic rabbit airway smooth muscle.
A1 adenosine receptors expressed in CHO-cells couple to adenylyl cyclase and to phospholipase C.
A1 adenosine receptors potently regulate heart rate in mammalian embryos.
A1 and A2 adenosine receptor modulation of contractility in the cauda epididymis of the guinea-pig.
A1 and A2 adenosine receptors in rabbit cortical collecting tubule cells. Modulation of hormone-stimulated cAMP.
A1-adenosine receptor-mediated inhibition of adipocyte adenylate cyclase and lipolysis in Zucker rats.
A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis.
A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation.
AB5 ADP-ribosylating toxins: comparative anatomy and physiology.
AB5 toxins.
Aberrant Gi protein coupled receptor-mediated cell survival signaling in rheumatoid arthritis B cell lines.
Abeta peptides can enter the brain through a defective blood-brain barrier and bind selectively to neurons.
Ability of delta-opioid receptors to interact with multiple G-proteins is independent of receptor density.
Abnormal dopamine sensitivity in some human prolactinomas.
Abnormal regulation of G protein alpha(i2) subunit in skin fibroblasts from insulin-resistant hypertensive individuals.
Abnormal regulation of renal proximal tubule Na(+)-K(+)-ATPase by G proteins in spontaneously hypertensive rats.
Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis.
Abnormalities of the myocytes in ischaemic cardiomyopathy.
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger.
Abscisic acid stimulation of phospholipase D in the barley aleurone is G-protein-mediated and localized to the plasma membrane.
Absence of D2S dopamine receptor in the prolactin-secreting MMQ pituitary clone: characterization of a wild D2L receptor coupled to native transduction mechanisms.
Absence of exon 10 of the human luteinizing hormone (LH) receptor impairs LH, but not human chorionic gonadotropin action.
Absence of the inhibitory effect of guanine nucleotides on adenylate cyclase activity in white adipocyte membranes of the ob/ob mouse. Effect of the ob gene.
Accelerated maternal responding following intra-VTA pertussis toxin treatment.
Acceleration of desipramine-induced changes on the dopamine receptor-coupled adenylate cyclase system by pertussis toxin.
Accentuated antagonism by angiotensin II on guinea-pig cardiac L-type Ca-currents enhanced by beta-adrenergic stimulation.
Accentuation by pertussis toxin of the 5-hydroxytryptamine-induced potentiation of ATP-evoked responses in rat pheochromocytoma cells.
Accumulation of a precursor of subunit S1 of pertussis toxin in cell envelopes of Bordetella pertussis in response to the membrane perturbant phenethyl alcohol.
Acellular and "low" pertussis vaccines: adverse events and the role of mutations.
Acellular and whole cell pertussis vaccines protect against the lethal effects of intracerebral challenge by two different T-cell dependent humoral routes.
Acellular pertussis vaccine as a booster dose for seventeen- to nineteen-month-old children immunized with either whole cell or acellular pertussis vaccine at two, four and six months of age.
Acellular pertussis vaccine based on outer membrane vesicles capable of conferring both long-lasting immunity and protection against different strain genotypes.
Acellular pertussis vaccine composed of genetically inactivated pertussis toxin.
Acellular pertussis vaccine composed of genetically inactivated pertussis toxin: safety and immunogenicity in 12- to 24- and 2- to 4-month-old children.
Acellular pertussis vaccine given by accelerated schedule: response of preterm infants.
Acellular pertussis vaccine in adults: adverse reactions and immune response.
Acellular pertussis vaccine in children with perinatal human immunodeficiency virus-type 1 infection.
Acellular pertussis vaccine prepared by a simple extraction and toxoiding procedure.
Acellular pertussis vaccines and the role of pertactin and fimbriae.
Acellular pertussis vaccines containing genetically detoxified pertussis toxin induce long-lasting humoral and cellular responses in adults.
Acellular pertussis vaccines developed in Japan and their application for disease control.
Acellular pertussis vaccines: evaluation of reversion in a nude mouse model.
Acellular pertussis vaccines: neutralization by immune sera of the lethality of pertussis toxin and viable Bordetella pertussis for chick embryos.
Acellular vaccines induce cell-mediated immunity to Bordetella pertussis antigens in infants undergoing primary vaccination against pertussis.
Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats.
Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein.
Acetylcholine activation of K+ channels in cell-free membrane of atrial cells.
Acetylcholine and adenosine activate the G protein-gated muscarinic K+ channel in ferret ventricular myocytes.
Acetylcholine and cholecystokinin receptors functionally couple by different G-proteins to phospholipase C in pancreatic acinar cells.
Acetylcholine elicits a rebound stimulation of Ca2+ current mediated by pertussis toxin-sensitive G protein and cAMP-dependent protein kinase A in atrial myocytes.
Acetylcholine elicits metabolically mediated M2-muscarinic hyperpolarization in isolated rabbit sympathetic neurons.
Acetylcholine inhibition in rabbit sinoatrial node is prevented by pertussis toxin.
Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase.
Acetylcholine modulation of high-voltage-activated calcium channels in the neurones acutely dissociated from rat paratracheal ganglia.
Acetylcholine reversal of isoproterenol-stimulated sodium currents in rabbit ventricular myocytes.
Acetylcholine reverses isoproterenol-induced depression of Vmax in residual Na channel-dependent action potentials of guinea-pig cardiac muscles.
Acetylcholine stimulates cortical precursor cell proliferation in vitro via muscarinic receptor activation and MAP kinase phosphorylation.
Acetylcholine-induced calcium signaling associated with muscarinic receptor activation in cultured myenteric neurons.
Acetylcholine-induced desensitization of muscarinic contractile response in Guinea pig ileum is inhibited by pertussis toxin treatment.
Acetylcholine-induced desensitization of the contractile response to histamine in Guinea pig ileum is prevented by either pertussis toxin treatment or by selective inactivation of muscarinic M(3) receptors.
Acetylcholine-sensitive muscarinic K+ channels in mammalian ventricular myocytes.
ACh-induced rebound stimulation of L-type Ca(2+) current in guinea-pig ventricular myocytes, mediated by Gbetagamma-dependent activation of adenylyl cyclase.
Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae.
Acidification of serotonin-containing secretory vesicles induced by a plasma membrane calcium receptor.
Acquisition by innervated cardiac myocytes of a pertussis toxin-specific regulatory protein linked to the alpha 1-receptor.
Acquisition of specific antibodies and their influence on cell-mediated immune response in neonatal cord blood after maternal pertussis vaccination during pregnancy.
Acrosome reaction induced by recombinant human zona pellucida 3 peptides rhuZP3a22 approximately 176 and rhuZP3b177 approximately 348 and their mechanism.
Actin assembly in electropermeabilized neutrophils: role of G-proteins.
Actin depolymerization and inhibition of capping induced by pentoxifylline in human lymphocytes and neutrophils.
Actin reorganization in airway smooth muscle cells involves Gq and Gi-2 activation of Rho.
Action of alpha 2A-adrenergic receptors in circular smooth muscle of canine proximal colon.
Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein.
Action of calcitonin gene-related peptide on rat aortic smooth muscle.
Action of insulin modulated by pertussis toxin in rat adipocytes.
Action of lipid peroxidation products on phosphoinositide specific phospholipase C.
Action of the cardiac alpha 1-adrenergic receptor. Activation of cyclic AMP degradation.
Actions of angiotensin II and noradrenaline on smooth muscle cells of the canine mesenteric artery.
Actions of epoxyeicosatrienoic acid on large-conductance Ca(2+)-activated K(+) channels in pituitary GH(3) cells.
Actions of peptide YY and neuropeptide Y on chief cells from guinea pig stomach.
Actions of pertussis toxin on the inhibitory effects of dopamine and somatostatin on prolactin and growth hormone release from ovine anterior pituitary cells.
Actions of somatostatins on gastric smooth muscle cells.
Activated G protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase. Resultant effects on cell proliferation.
Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells.
Activation and inhibition of neuronal G protein-gated inwardly rectifying K(+) channels by P2Y nucleotide receptors.
Activation and modulation of neuronal K+ channels by GABA.
Activation by 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, of p42/44 mitogen-activated protein kinase in HL-60 cells.
Activation by chemotactic peptide of a receptor-operated Ca2+ entry pathway in differentiated HL60 cells.
Activation by thiol of the latent NAD glycohydrolase and ADP-ribosyltransferase activities of Bordetella pertussis toxin (islet-activating protein).
Activation effects of a prion protein fragment [PrP-(106-126)] on human leucocytes.
Activation mechanism of a neuromodulator-gated pacemaker ionic current.
Activation of 5-HT(7) receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels.
Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis.
Activation of ?-opioid receptors inhibits calcium-currents in the vestibular afferent neurons of the rat through a cAMP dependent mechanism.
Activation of a beta-adrenergic-sensitive signal transduction pathway by the secosteroid hormone 1,25-(OH)2-vitamin D3 in chick heart.
Activation of a Ca2+-dependent K+ current in mouse fibroblasts by lysophosphatidic acid requires a pertussis toxin-sensitive G protein and Ras.
Activation of a calcium-permeable cation channel CD20 expressed in Balb/c 3T3 cells by insulin-like growth factor-I.
Activation of a common potassium channel in molluscan neurones by glutamate, dopamine and muscarinic agonist.
Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat.
Activation of a G protein in mouse sperm by the zona pellucida, an egg-associated extracellular matrix.
Activation of a G protein promotes agonist responses to calcium channel ligands.
Activation of a Gi protein in digitonin/cholate-solubilized membrane preparations of mouse sperm by the zona pellucida, an egg-specific extracellular matrix.
Activation of a Gi protein in mouse sperm membranes by solubilized proteins of the zona pellucida, the egg's extracellular matrix.
Activation of a K+ conductance by bradykinin and by inositol-1,4,5-trisphosphate in rat glioma cells: involvement of intracellular and extracellular Ca2+.
Activation of a keratinocyte phospholipase A2 by bradykinin and 4 beta-phorbol 12-myristate 13-acetate. Evidence for a receptor-GTP-binding protein versus a protein-kinase-C mediated mechanism.
Activation of a mitogen-activated protein kinase (ERK2) by the 5-hydroxytryptamine1A receptor is sensitive not only to inhibitors of phosphatidylinositol 3-kinase, but to an inhibitor of phosphatidylcholine hydrolysis.
Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons.
Activation of a pertussis toxin-sensitive, inhibitory G-protein is necessary for steroid-mediated oocyte maturation in spotted seatrout.
Activation of a pertussis-toxin-sensitive guanine-nucleotide-binding regulatory protein during desensitization of Dictyostelium discoideum cells to chemotactic signals.
Activation of a phosphatidylcholine-specific phospholipase C by colony stimulating factor 1 receptor requires tyrosine phosphorylation and a guanine nucleotide-binding protein.
Activation of a PTX-insensitive G protein is involved in histamine-induced recombinant M-channel modulation.
Activation of A(3) adenosine receptor induces calcium entry and chloride secretion in A(6) cells.
Activation of adenosine A(1) receptor modulates dopamine D(1) receptor activity in stably cotransfected human embryonic kidney 293 cells.
Activation of adenosine A1 and bradykinin receptors increases protein kinase C and phospholipase D activity in smooth muscle cells.
Activation of adenylate cyclase by human recombinant sst5 receptors expressed in CHO-K1 cells and involvement of Galphas proteins.
Activation of adenylate cyclase in rat fat cells promotes an increase in GTP content which controls the enzyme activity.
Activation of Akt/protein kinase B after stimulation with angiotensin II in vascular smooth muscle cells.
Activation of alpha 1- and alpha 2-adrenoceptors inhibits noradrenaline release in rabbit renal arteries: effects of pertussis toxin and N-ethylmaleimide.
Activation of alpha 1-adrenoceptors modulates the inwardly rectifying potassium currents of mammalian atrial myocytes.
Activation of alpha 2-adrenergic receptors decreases Ca2+ influx to inhibit insulin secretion in a hamster beta-cell line: an action mediated by a guanosine triphosphate-binding protein.
Activation of alpha-1A adrenoceptors mobilizes calcium from the intracellular stores in myocytes from rat portal vein.
Activation of alpha-2 adrenergic receptors inhibits norepinephrine release by a pertussis toxin-insensitive pathway independent of changes in cytosolic calcium in cultured rat sympathetic neurons.
Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells.
Activation of apical P2U purine receptors permits inhibition of adrenaline-evoked cyclic AMP accumulation in cultured equine sweat gland epithelial cells.
Activation of beta-adrenergic receptors inhibits Ca2+ entry-mediated generation of inositol phosphates in the guinea pig myometrium, a cyclic AMP-independent event.
Activation of BK channels in GH3 cells by a c-PLA2-dependent G-protein signaling pathway.
Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 fibroblasts.
Activation of Ca(2+)-dependent K+ current by acetylcholine and histamine in a human gastric epithelial cell line.
Activation of calcium-permeable cation channel by insulin in Chinese hamster ovary cells expressing human insulin receptors.
Activation of CD47 receptors causes histamine secretion from mast cells.
Activation of cell membrane potassium conductance by mercury in cultured renal epithelioid (MDCK) cells.
Activation of cellular phospholipase A2 by Clostridium difficile toxin B.
Activation of choline kinase by extracellular Ca2+ is Ca(2+)-sensing receptor, Galpha12 and Rho-dependent in breast cancer cells.
Activation of constitutive 5-hydroxytryptamine(1B) receptor by a series of mutations in the BBXXB motif: positioning of the third intracellular loop distal junction and its G(o)alpha protein interactions.
Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC eposilon pathway.
Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells.
Activation of delta-opioid receptors inhibits neuronal-like calcium channels and distal steps of Ca(2+)-dependent secretion in human small-cell lung carcinoma cells.
Activation of dense human tonsilar B cells. Induction of c-myc gene expression via two distinct signal transduction pathways.
Activation of distinct T cell subsets involved in IgM antibody response of mice by pertussis toxin from Bordetella pertussis strain Maeno.
Activation of dopamine D4 receptor inhibits an L-type calcium current in cerebellar granule cells.
Activation of dopamine receptors does not affect phosphoinositide turnover in NCB-20 cells.
Activation of early events of the mitogenic response by a P2Y purinoceptor with covalently bound 3'-O-(4-benzoyl)-benzoyladenosine 5'-triphosphate.
Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate.
Activation of endothelial nitric oxide synthase by proanthocyanidin-rich fraction from Croton celtidifolius (Euphorbiaceae): involvement of extracellular calcium influx in rat thoracic aorta.
Activation of extracellular signal regulated protein kinase by neuropeptide Y and pancreatic polypeptide in CHO cells expressing the NPY Y(1), Y(2), Y(4) and Y(5) receptor subtypes.
Activation of G protein by opioid receptors: role of receptor number and G-protein concentration.
Activation of G protein-coupled K+ channels by dopamine in human GH-producing cells.
Activation of G proteins bidirectionally affects apoptosis of cultured cerebellar granule neurons.
Activation of G proteins by (Rp) and (Sp) diastereomers of guanosine 5'-[beta-thio]triphosphate in hamster fibroblasts. Differential stereospecificity of Gi, Gs and Gp.
Activation of G proteins may inhibit or stimulate surfactant secretion in rat alveolar type II cells.
Activation of G proteins mediates flow-induced prostaglandin E2 production in osteoblasts.
Activation of G(i) induces mechanical hyperalgesia poststress or inflammation.
Activation of galanin receptor 1 inhibits locus coeruleus neurons via GIRK channels.
Activation of Galpha (i) and subsequent uncoupling of receptor-Galpha(i) signaling by Pasteurella multocida toxin.
Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation.
Activation of Gi protein by peptide structures of the muscarinic M2 receptor second intracellular loop.
Activation of Gi-like proteins, a receptor-independent effect of kinins in mast cells.
Activation of Go-coupled dopamine D2 receptors inhibits ERK1/ERK2 in pituitary cells. A key step in the transcriptional suppression of the prolactin gene.
Activation of group I metabotropic glutamate receptors induces long-term depression at sensory synapses in superficial spinal dorsal horn.
Activation of group II mGlu receptors inhibits voltage-gated Ca2+ currents in myenteric neurons.
Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures.
Activation of growth hormone secretagogue type 1a receptor inhibits T-type Ca2+ channel currents through pertussis toxin-sensitive novel protein kinase C pathway in mouse spermatogenic cells.
Activation of GTP formation and high-affinity GTP hydrolysis by mastoparan in various cell membranes. G-protein activation via nucleoside diphosphate kinase, a possible general mechanism of mastoparan action.
Activation of guanosine 5'-[gamma-(35)S]thio-triphosphate binding through M(1) muscarinic receptors in transfected Chinese Hamster ovary cell membranes: 2. Testing the "two-states" model of receptor activation.
Activation of guanylate cyclase by E. coli heat-stable enterotoxin (STa). Modulation by NAD and pertussis toxin.
Activation of heat shock protein (hsp)70 and proto-oncogene expression by alpha1 adrenergic agonist in rat aorta with age.
Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors.
Activation of heterotrimeric G proteins by Smoothened.
Activation of HIF-1? by ?-Opioid Receptors Induces COX-2 Expression in Breast Cancer Cells and Leads to Paracrine Activation of Vascular Endothelial Cells.
Activation of human basophils through the IL-8 receptor.
Activation of human colon mast cells through proteinase activated receptor-2.
Activation of human monocytes by a formyl peptide receptor 2-derived pepducin.
Activation of human monocytes via a non-neurokinin substance P receptor that is coupled to Gi protein, calcium, phospholipase D, MAP kinase, and IL-6 production.
Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate.
Activation of human neutrophils by a synthetic anti-microbial peptide, KLKLLLLLKLK-NH2, via cell surface calreticulin.
Activation of human neutrophils by chlordane: induction of superoxide production and phagocytosis but not chemotaxis or apoptosis.
Activation of human neutrophils by mastoparan. Reorganization of the cytoskeleton, formation of phosphatidylinositol 3,4,5-trisphosphate, secretion up-regulation of complement receptor type 3 and superoxide anion production are stimulated by mastoparan.
Activation of human neutrophils by Mycobacterium tuberculosis-derived sulfolipid-1.
Activation of human neutrophils by substance P. Effect on oxidative metabolism, exocytosis, cytosolic Ca2+ concentration and inositol phosphate formation.
Activation of human neutrophils by technical toxaphene.
Activation of human neutrophils by the plant lectin Viscum album agglutinin-I: modulation of de novo protein synthesis and evidence that caspases are involved in induction of apoptosis.
Activation of human tonsil and skin mast cells by agonists of proteinase activated receptor-2.
Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
Activation of inositol phospholipid breakdown in HL60 cells by P2-purinergic receptors for extracellular ATP. Evidence for mediation by both pertussis toxin-sensitive and pertussis toxin-insensitive mechanisms.
Activation of inositol phospholipid turnover and calcium signaling in rat Sertoli cells by P2-purinergic receptors: modulation of follicle-stimulating hormone responses.
Activation of inwardly rectifying potassium channels by muscarinic receptor-linked G protein in isolated human ventricular myocytes.
Activation of LH receptors expressed in GnRH neurons stimulates cyclic AMP production and inhibits pulsatile neuropeptide release.
Activation of lipolysis and cyclic AMP accumulation in rabbit adipocytes by isoproterenol in the presence of forskolin or pertussis toxin.
Activation of M1 muscarinic receptors triggers transmitter release from rat sympathetic neurons through an inhibition of M-type K+ channels.
Activation of M3 muscarinic receptors inhibits T-type Ca(2+) channel currents via pertussis toxin-sensitive novel protein kinase C pathway in small dorsal root ganglion neurons.
Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony-stimulating factor (CSF-1): involvement of a pertussis toxin-sensitive reaction.
Activation of MAP kinase by the LHRH receptor through a dual mechanism involving protein kinase C and a pertussis toxin-sensitive G protein.
Activation of MAPK by TRH requires clathrin-dependent endocytosis and PKC but not receptor interaction with beta-arrestin or receptor endocytosis.
Activation of mast cell K+ channels through multiple G protein-linked receptors.
Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation.
Activation of mesangial cells with TNF-alpha stimulates M-CSF gene expression and monocyte proliferation: evidence for involvement of protein kinase C and protein tyrosine kinase.
Activation of metabotropic glutamate receptors by L-AP4 stimulates survival of rat cerebellar granule cells in culture.
Activation of microtubule-associated protein kinase (Erk) and p70 S6 kinase by D2 dopamine receptors.
Activation of mislocalized opsin kills rod cells: a novel mechanism for rod cell death in retinal disease.
Activation of mitogen-activated protein kinase and arachidonate release via two G protein-coupled receptors expressed in the rat hippocampus.
Activation of mitogen-activated protein kinase by muscarinic receptors in astroglial cells: role in DNA synthesis and effect of ethanol.
Activation of mitogen-activated protein kinase by oxidized low-density lipoprotein in canine cultured vascular smooth muscle cells.
Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24.
Activation of mitogen-activated protein kinase in BC3H1 myocytes by fluoroaluminate.
Activation of mitogen-activated protein kinases by formyl peptide receptors is regulated by the cytoplasmic tail.
Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1.
Activation of mu-opioid receptor induces expression of c-fos and junB via mitogen-activated protein kinase cascade.
Activation of muscarinic cholinergic receptors in mouse neuroblastoma x rat glioma hybrid cells: rapid induction of enhanced capacity of prostaglandin E1 receptors to stimulate cyclic AMP accumulation.
Activation of muscarinic K+ current by beta-adrenergic receptors in cultured atrial myocytes transfected with beta1 subunit of heterotrimeric G proteins.
Activation of muscarinic K+ current in guinea-pig atrial myocytes by a serum factor.
Activation of muscarinic K+ current in guinea-pig atrial myocytes by sphingosine-1-phosphate.
Activation of muscarinic M(4) receptor augments NGF-induced pro-survival Akt signaling in PC12 cells.
Activation of muscarinic m5 receptors inhibits recombinant KCNQ2/KCNQ3 K+ channels expressed in HEK293T cells.
Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation.
Activation of muscarinic receptors in PC12 cells. Correlation between cytosolic Ca2+ rise and phosphoinositide hydrolysis.
Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors.
Activation of Na+/Ca2+ exchange by adenosine in ewe heart sarcolemma is mediated by a pertussis toxin-sensitive G protein.
Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides.
Activation of natriuretic peptide receptor-C attenuates the enhanced oxidative stress in vascular smooth muscle cells from spontaneously hypertensive rats: implication of Gialpha protein.
Activation of neuromedin U type 1 receptor inhibits L-type Ca2+ channel currents via phosphatidylinositol 3-kinase-dependent protein kinase C epsilon pathway in mouse hippocampal neurons.
Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes.
Activation of nuclear Ca(2+)/calmodulin-dependent protein kinase II and brain-derived neurotrophic factor gene expression by stimulation of dopamine D2 receptor in transfected NG108-15 cells.
Activation of nucleotide receptors inhibits high-threshold calcium currents in NG108-15 neuronal hybrid cells.
Activation of nucleotide receptors inhibits M-type K current [IK(M)] in neuroblastoma x glioma hybrid cells.
Activation of opioid and muscarinic receptors stimulates basal adenylyl cyclase but inhibits Ca2+/calmodulin- and forskolin-stimulated enzyme activities in rat olfactory bulb.
Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells.
Activation of p21-activated kinase 1-nuclear factor kappaB signaling by Kaposi's sarcoma-associated herpes virus G protein-coupled receptor during cellular transformation.
Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts.
Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C.
Activation of p38 mitogen-activated protein kinase by oxidized LDL in vascular smooth muscle cells: mediation via pertussis toxin-sensitive G proteins and association with oxidized LDL-induced cytotoxicity.
Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2alpha in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive mechanisms.
Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury.
Activation of particulate guanylate cyclase by adrenomedullin in cultured SV-40 transformed cat iris sphincter smooth muscle (SV-CISM-2) cells.
Activation of permeabilized neutrophils: role of anions.
Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells.
Activation of phosphatidylinositol 3-kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role of the G-protein-coupled signals for the lectin-induced respiratory burst in human monocytic THP-1 cells.
Activation of phosphatidylinositol 3-kinase/Akt signaling pathway and endogenous nitric oxide are needed for the antiarrhythmic effect of centrally administered rilmenidine.
Activation of phosphoinositide turnover and protein kinase C by neurotransmitters that modulate calcium channels in embryonic chick sensory neurons.
Activation of phosphoinositide-specific phospholipase C of rat neutrophils by the chemotactic aldehydes 4-hydroxy-2,3-trans-nonenal and 4-hydroxy-2,3-trans-octenal.
Activation of phospholipase A2 by the human endothelin receptor in Chinese hamster ovary cells involves Gi protein-mediated calcium influx.
Activation of phospholipase A2 by the nociceptin receptor expressed in Chinese hamster ovary cells.
Activation of phospholipase C and phospholipase D by stimulation of adenosine A1, bradykinin or P2U receptors does not correlate well with protein kinase C activation.
Activation of phospholipase C by G-protein beta gamma subunits in DDT1MF-2 cells.
Activation of phospholipase C by heat shock requires GTP analogs and is resistant to pertussis toxin.
Activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells. Evidence for a novel adenosine receptor.
Activation of phospholipase C-beta1 via Galphaq/11 during calcium mobilization by calcitonin gene-related peptide.
Activation of phospholipase D by E-series prostaglandins in human erythroleukemia cells.
Activation of phospholipase D by endothelin-1 in rat myometrium. Role of calcium and protein kinase C.
Activation of phospholipase D by interleukin-8 in human neutrophils.
Activation of phospholipase D in rabbit neutrophils by fMet-Leu-Phe is mediated by a pertussis toxin-sensitive GTP-binding protein that may be distinct from a phospholipase C-regulating protein.
Activation of phospholipase D signaling pathway by epidermal growth factor in osteoblastic cells.
Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonensis promastigotes.
Activation of PKCbeta(II) and PKCtheta is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation.
Activation of porcine oocytes via an exogenously introduced rat muscarinic M1 receptor.
Activation of presynaptic GABAB receptors inhibits evoked IPSCs in rat magnocellular neurons in vitro.
Activation of protein kinase B by adenosine A1 and A3 receptors in newborn rat cardiomyocytes.
Activation of protein kinase B by the A(1)-adenosine receptor in DDT(1)MF-2 cells.
Activation of protein kinase C inhibits hormonal stimulation of the GTPase activity of Gi in human platelets.
Activation of PtdIns(4,5)P2-sensitive phospholipase C in rabbit tracheal epithelial cells.
Activation of Ras and mitogen-activated protein kinase pathway by terminal complement complexes is G protein dependent.
Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function.
Activation of rat peritoneal mast cells by substance P and mastoparan.
Activation of serum response element by D2 dopamine receptor is governed by Gbetagamma-mediated MAPK and Rho pathways and regulated by RGS proteins.
Activation of signaling pathways in HL60 cells and human neutrophils by farnesylthiosalicylate.
Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration.
Activation of spinal ?2 adrenergic receptors induces hyperglycemia in mouse though activating sympathetic outflow.
Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts.
Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides.
Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD18.
Activation of the Ca2+ message system by parathyroid hormone is dependent on the cell cycle.
Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands.
Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis.
Activation of the extracellular signal-regulated kinase 2 by metabotropic glutamate receptors.
Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes.
Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG.
Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia.
Activation of the human FPRL-1 receptor promotes Ca2+ mobilization in U87 astrocytoma cells.
Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic acid: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins.
Activation of the human neutrophil 5-lipoxygenase by leukotriene B4.
Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase.
Activation of the mitogen-activated protein kinase cascade by pertussis toxin-sensitive and -insensitive pathways in cultured ventricular cardiomyocytes.
Activation of the mitogen-activated protein kinase pathway by fMet-leu-Phe in the absence of Lyn and tyrosine phosphorylation of SHC in transfected cells.
Activation of the mitogen-activated protein kinases Erk1/2 by erythropoietin receptor via a G(i )protein beta gamma-subunit-initiated pathway.
Activation of the muscarinic K+ channel by P2-purinoceptors via pertussis toxin-sensitive G proteins in guinea-pig atrial cells.
Activation of the p38 and p42/p44 mitogen-activated protein kinase families by the histamine H(1) receptor in DDT(1)MF-2 cells.
Activation of the prostaglandin FP receptor in human granulosa cells.
Activation of the Ras-GRF/CDC25Mm exchange factor by lysophosphatidic acid.
Activation of the respiratory burst and tyrosine phosphorylation of proteins in human neutrophils: no direct relationship and involvement of protein kinase C-dependent and -independent signaling pathways.
Activation of the respiratory burst in eosinophil leucocytes--a transduction sequence decoupled from cytosolic Ca2+ rise.
Activation of the respiratory burst in murine phagocytes by certain guanine ribonucleosides modified at the 7 and 8 positions: possible involvement of a pertussis toxin-sensitive G-protein.
Activation of the superoxide-generating NADPH oxidase of macrophages by sodium dodecyl sulfate in a soluble cell-free system: evidence for involvement of a G protein.
Activation of the {beta}-catenin/T-cell-specific transcription factor/lymphoid enhancer factor-1 pathway by plasminogen activators in ECV304 carcinoma cells.
Activation of type II adenylate cyclase by D2 and D4 but not D3 dopamine receptors.
Activation of various G-protein coupled receptors modulates Ca2+ channel currents via PTX-sensitive and voltage-dependent pathways in rat intracardiac neurons.
Activation of voltage-dependent calcium channels of mammalian sperm is required for zona pellucida-induced acrosomal exocytosis.
Activation of Wiskott-Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in a T-lymphocyte line.
Activation-independent exposure of the GPIIb-IIIa fibrinogen receptor.
Activator of G-protein signaling in asymmetric cell divisions of the sea urchin embryo.
Activators of protein kinase C selectively enhance inactivation of a calcium current component of cultured sensory neurons in a pertussis toxin-sensitive manner.
Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG35-55 in the Mouse.
Active induction of experimental autoimmune encephalomyelitis by MOG35-55 peptide immunization is associated with differential responses in separate compartments of the choroid plexus.
Active Induction of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice.
Active lymphocyte traffic induced in the periphery by cytokines and phytohemagglutinin: three different mechanisms?
Active movement of T cells away from a chemokine.
Active transducin alpha subunit carries PDE6 to detergent-resistant membranes in rod photoreceptor outer segments.
Activin A induces dendritic cell migration through the polarized release of CXCL12 and CXCL14.
Activin-A modulates growth hormone secretion from cultures of rat anterior pituitary cells.
Activities of complete and truncated forms of pertussis toxin subunits S1 and S2 synthesized by Escherichia coli.
Activity of adenosine diphosphates and triphosphates on a P2Y(T) -type receptor in brain capillary endothelial cells.
Acute and chronic effects of dexfenfluramine on the porcine coronary artery.
Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.
Acute and delayed renal protection against renal ischemia and reperfusion injury with A1 adenosine receptors.
Acute ethanol-induced adenosine diphosphate ribosylation regulates the functional activity of rat striatal pertussis toxin-sensitive g proteins.
Acute exacerbation of idiopathic pulmonary fibrosis induced by pertussis: the first case report.
Acute inhibition of the betaine transporter by ATP and adenosine in renal MDCK cells.
Acute morphine alters GABAergic transmission in the central amygdala during naloxone-precipitated morphine withdrawal: role of cyclic AMP.
Acute stress-induced hyperinsulinemia in the pertussis toxin-treated rat: possible role of humoral beta-cell-tropic factors.
Acute-phase, but not constitutive serum amyloid A (SAA) is chemotactic for cultured human aortic smooth muscle cells.
Adaptation of Bordetella pertussis to vaccination: a cause for its reemergence?
Adaptations to chronic agonist exposure of mu-opioid receptor-expressing Chinese hamster ovary cells.
Adaptive responses of human monocytes infected by bordetella pertussis: the role of adenylate cyclase hemolysin.
Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF-alpha receptor 1-independent and -dependent mechanisms.
Additive induction of Egr-1 (zif/268) mRNA expression in neuroblastoma x glioma hybrid NG108-15 cells via cholinergic muscarinic, alpha 2-adrenergic, and bradykinin receptors.
Adenine nucleotides directly stimulate pertussis toxin.
Adenine nucleotides inhibit recombinant N-type calcium channels via G protein-coupled mechanisms in HEK 293 cells; involvement of the P2Y13 receptor-type.
Adenine nucleotides promote dissociation of pertussis toxin subunits.
Adenine-induced inhibition of Na(+)-ATPase activity: Evidence for involvement of the Gi protein-coupled receptor in the cAMP signaling pathway.
Adenosine 3',5'-cyclic monophosphate-stimulated Ca++ efflux and acetylcholine release in ileal myenteric plexus are mediated by N-type Ca++ channels: inhibition by the kappa opioid receptor agonist.
Adenosine 5'-triphosphate, phorbol ester, and pertussis toxin effects on atrial natriuretic peptide stimulation of guanylate cyclase in a human renal cell line.
Adenosine A(1) receptor stimulation inhibits alpha(1)-adrenergic activation of the cardiac sarcolemmal Na(+)/H(+) exchanger.
Adenosine A(1) receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitro.
Adenosine A(2a)-receptor activation increases contractility in isolated perfused hearts.
Adenosine A1 agonists and the Ca2+ channel agonist bay K 8644 produce a synergistic stimulation of the GTPase activity of Go in rat frontal cortical membranes.
Adenosine A1 and A2b receptors coupled to distinct interactive signaling pathways in intestinal muscle cells.
Adenosine A1 and class II metabotropic glutamate receptors mediate shared presynaptic inhibition of retinotectal transmission.
Adenosine A1 but not A2a receptor agonist reduces hyperalgesia caused by a surgical incision in rats: a pertussis toxin-sensitive G protein-dependent process.
Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons.
Adenosine A1 receptor-induced upregulation of protein kinase C: role of pertussis toxin-sensitive G protein(s).
Adenosine A1 receptor-mediated activation of phospholipase C-beta 3 in intestinal muscle: dual requirement for alpha and beta gamma subunits of Gi3.
Adenosine A1 receptor-mediated inhibition of in vitro prolactin secretion from the rat anterior pituitary.
Adenosine A1 receptor-mediated inhibition of vasopressin action in inner medullary collecting duct.
Adenosine A1 receptor-mediated modulation of dopamine D1 receptors in stably cotransfected fibroblast cells.
Adenosine A1 receptors inhibit both adenylate cyclase activity and TRH-activated Ca2+ channels by a pertussis toxin-sensitive mechanism in GH3 cells.
Adenosine A1 receptors mediate mobilization of calcium in human bronchial smooth muscle cells.
Adenosine A1 receptors mediate retinotectal presynaptic inhibition: uncoupling by C-kinase and role in LTP during regeneration.
Adenosine A1-receptor coupling to phosphoinositide metabolism in pregnant guinea pig myometrium.
Adenosine A1-receptor stimulated increases in intracellular calcium in the smooth muscle cell line, DDT1MF-2.
Adenosine A1-receptors inhibit cAMP and Ca2+ mediated calcitonin secretion in C-cells.
Adenosine A2a and A2b receptors in cultured fetal chick heart cells. High- and low-affinity coupling to stimulation of myocyte contractility and cAMP accumulation.
Adenosine A2a-receptor activation enhances cardiomyocyte shortening via Ca2+-independent and -dependent mechanisms.
Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3'-kinase.
Adenosine acting at an A1 receptor decreases N-type calcium current in mouse motoneurons.
Adenosine activates the K+ channel and enhances cytosolic Ca2+ release via a P2Y purinoceptor in hippocampal neurons.
Adenosine activation of a nuclear pool of protein kinase C in rat splenocytes.
Adenosine acts as an endogenous activator of the cellular antioxidant defense system.
Adenosine and 5-HT inhibit substance P release from nerve endings in myenteric ganglia by distinct mechanisms.
Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells.
Adenosine attenuates calcium paradox injury: role of adenosine A1 receptor.
Adenosine diphosphate ribosylation of G proteins by pertussis and cholera toxin in isolated membranes. Different requirements for and effects of guanine nucleotides and Mg2+.
Adenosine induces C1- efflux in endothelial cells via a pertussis toxin-sensitive G protein.
Adenosine induces vasoconstriction through Gi-dependent activation of phospholipase C in isolated perfused afferent arterioles of mice.
Adenosine inhibition of the hormonal response in the Sertoli cell is reversed by pertussis toxin.
Adenosine inhibitory effect on enhanced growth of aortic smooth muscle cells from streptozotocin-induced diabetic rats.
Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect.
Adenosine inhibits fMLP-stimulated adherence and superoxide anion generation by human neutrophils at an early step in signal transduction.
Adenosine inhibits histamine-induced phosphoinositide hydrolysis mediated via pertussis toxin-sensitive G protein in human astrocytoma cells.
Adenosine inhibits L- and N-type calcium channels in pituitary melanotrophs. Evidence for the involvement of a G protein in calcium channel gating.
Adenosine inhibits the renal plasma-membrane (Ca2+ + Mg2+)-ATPase through a pathway sensitive to cholera toxin and sphingosine.
Adenosine inhibits the synaptic potentials in rat septal nucleus neurons mediated through pre- and postsynaptic A1-adenosine receptors.
Adenosine inhibits voltage-dependent Ca2+ currents in rat dissociated supraoptic neurones via A1 receptors.
Adenosine modulates voltage-gated Ca2+ channels in adult rat sympathetic neurons.
Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis.
Adenosine potentiates the delayed-rectifier potassium conductance but has no effect on the hyperpolarization-activated Ih current in frog melanotrophs.
Adenosine receptor activation potentiates phosphoinositide hydrolysis and arachidonic acid release in DDT1-MF2 cells: putative interrelations.
Adenosine receptor down-regulation and insulin resistance following prolonged incubation of adipocytes with an A1 adenosine receptor agonist.
Adenosine receptor mediates motility in human melanoma cells.
Adenosine receptor-induced cAMP changes in D384 astrocytoma cells and the effect of bradykinin thereon.
Adenosine receptor-mediated calcium mobilization in cortical collecting tubule cells.
Adenosine receptor-mediated relaxation in coronary artery: evidence for a guanyl nucleotide-binding regulatory protein involvement.
Adenosine receptors mediate a pertussis toxin-insensitive prejunctional inhibition of noradrenaline release on a papillary muscle model.
Adenosine regulates a chloride channel via protein kinase C and a G protein in a rabbit cortical collecting duct cell line.
Adenosine release and uptake in cerebellar granule neurons both occur via an equilibrative nucleoside carrier that is modulated by G proteins.
Adenosine stimulation of AMP deaminase activity in adult rat cardiac myocytes.
Adenosine triphosphate activates mitogen-activated protein kinase in human granulosa-luteal cells.
Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca(++) mobilization and actin reorganization in human eosinophils.
Adenosine, through the A(1) receptor, inhibits vesicular MHC class I cross-presentation by resting DC.
Adenosine-dependent enhancement by methylxanthines of excitatory synaptic transmission in hippocampus of rats.
Adenosine-mediated inhibition of casein production by mouse mammary glands in culture.
Adenosine-sensitive afterdepolarizations and triggered activity in guinea pig ventricular myocytes.
Adenosine-sensitive phosphoinositide turnover in a newly established renal cell line.
Adenosinergic modulation of ethanol-induced motor incoordination in the rat motor cortex.
Adenylate cyclase activity in microdissected rat liver tissue: periportal to pericentral activity gradient.
Adenylate cyclase activity of v-ras-k transformed rat epithelial thyroid cells.
Adenylate cyclase in human cytotrophoblasts: characterization and its role in modulating human chorionic gonadotropin secretion.
Adenylate cyclase system in fetal rat keratinizing epidermal cells (FRSK cells) and SV40-transformed human keratinocytes.
Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice.
Adenylate cyclase toxin-mediated delivery of the S1 subunit of pertussis toxin into mammalian cells.
Adenylyl cyclase activity in clonally derived human myoblast cultures: evidence for myoblast heterogeneity.
Adenylyl cyclase and G-proteins in Phytomonas.
Adenylyl cyclase inhibitory pathway is differentially modified in rat white and brown fat by high-energy diets.
Adenylyl cyclase integrates multiple G protein signals to modulate calcium currents in neonatal rabbit heart.
Adenylyl cyclase interaction with the D2 dopamine receptor family; differential coupling to Gi, Gz, and Gs.
Adenylyl cyclase is involved in desensitization and recovery of ATP-stimulated Cl- secretion in MDCK cells.
Adenylyl cyclase type II activity is regulated by two different mechanisms: implications for acute and chronic opioid exposure.
Adenylyl cyclase type-VIII activity is regulated by G(betagamma) subunits.
Adequate tetanus but poor diphtheria and pertussis response to a Tdap booster in adolescents with juvenile systemic lupus erythematosus.
Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.
Adipocyte plasma membranes contain two Gi subtypes but are devoid of Go.
Adjuvant action of cholera toxin and pertussis toxin in the induction of IgA antibody response to orally administered antigen.
Adjuvant effect of pertussis toxin on the production of anti-ovalbumin IgE in mice and lack of direct correlation between PCA and ELISA.
Adjuvant immunotherapy of C6 glioma in rats with pertussis toxin.
Adjuvanticity of native and detoxified adenylate cyclase toxin of Bordetella pertussis towards co-administered antigens.
Adjuvanticity of pertussis toxin is mediated by differential effects on the activity of T suppressor, T amplifier and T helper cells.
Adoptive transfer of tumor-primed, in vitro-activated, CD4+ T effector cells (TEs) combined with CD8+ TEs provides intratumoral TE proliferation and synergistic antitumor response.
ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells.
ADP receptor antagonists inhibit platelet aggregation induced by the chemokines SDF-1, MDC and TARC.
ADP ribosylation by cholera toxin identifies three G-proteins that are activated by the galanin receptor. Studies with RINm5F cell membranes.
ADP-ribosyl proteins formed by pertussis toxin are specifically cleaved by mercury ions.
ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae represents unique virulence determinant among bacterial pathogens.
ADP-ribosylation activity in pertussis vaccines and its relationship to the in vivo histamine-sensitisation test.
ADP-ribosylation and early transcription regulation by bacteriophage T4.
ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils.
ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding.
ADP-ribosylation of alpha i3C20 by the S1 subunit and deletion peptides of S1 of pertussis toxin.
ADP-ribosylation of alpha-Gi proteins by pertussis toxin. Positional dissection of acceptor sites using membrane anchored synthetic peptides.
ADP-ribosylation of bovine S-antigen by cholera toxin.
ADP-ribosylation of cerebrocortical synaptosomal proteins by cholera, pertussis and botulinum toxins.
ADP-ribosylation of G proteins with pertussis toxin.
ADP-ribosylation of membrane proteins by bacterial toxins in the presence of NAD glycohydrolase.
ADP-ribosylation of signal-transducing guanine nucleotide-binding proteins by pertussis toxin.
ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.
ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.
ADP-ribosylation of transducin by pertussis toxin.
ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes.
ADP-ribosyltransferase activity of pertussis toxin and immunomodulation by Bordetella pertussis.
ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin.
Adrenal medullary opioid receptors are linked to GTP-binding proteins, pertussis toxin substrates.
Adrenaline inhibits depolarization-induced increases in capacitance the presence of elevated [Ca2+]i in insulin secreting cells.
Adrenaline-, not somatostatin-induced hyperpolarization is accompanied by a sustained inhibition of insulin secretion in INS-1 cells. Activation of sulphonylurea K+ATP channels is not involved.
Adrenergic agonists induce heterologous sensitization of adenylate cyclase in NS20Y-D(2L) cells.
Adrenergic and cholinergic inhibition of Ca2+ channels mediated by different GTP-binding proteins in rat sympathetic neurones.
Adrenergic control of cAMP generation in rat inner medullary collecting tubule cells.
Adrenergic inhibition of insulin secretion involves pertussis toxin-sensitive and -insensitive mechanisms.
Adrenergic receptor-mediated regulation of cultured rabbit airway smooth muscle cell proliferation.
Adrenergic receptors coupled to adenylate cyclase in human cerebromicrovascular endothelium.
Adrenergic receptors inhibit TRPV1 activity in the dorsal root ganglion neurons of rats.
Adrenergic regulation of the intracellular [Ca2+] and voltage-operated Ca2+ channel currents in the rat prostate neuroendocrine cells.
Adrenergic stimulation of vascular prostacyclin: role of alpha 1-receptors in smooth muscle cells.
Adrenergic-cholinergic interactions in left atria: a study using K+ channel agonists, antagonist and pertussis toxin.
Adrenoceptor-activation of oxygen consumption in rat parotid acini.
Adrenomedullin inhibits insulin exocytosis via pertussis toxin-sensitive G protein-coupled mechanism.
Adult formulation of a five component acellular pertussis vaccine combined with diphtheria and tetanus toxoids and inactivated poliovirus vaccine is safe and immunogenic in adolescents and adults.
Adult immunization with acellular pertussis vaccine.
Adult pertussis is unrecognized public health problem in Thailand.
Advanced glycation end products (AGEs) activate mast cells.
Adverse effects and sero-responses to an acellular pertussis/diphtheria/tetanus vaccine when combined with Haemophilus influenzae type b vaccine in an accelerated schedule.
Adverse events and antibody response to accelerated immunisation in term and preterm infants.
Adverse reactions and antibody response to an acellular pertussis toxoid vaccine in adult volunteers.
Adverse reactions and antibody response to four doses of acellular or whole cell pertussis vaccine combined with diphtheria and tetanus toxoids in the first 19 months of life.
Adverse reactions and antibody responses to acellular pertussis vaccine.
Adverse reactions and serologic response to a booster dose of acellular pertussis vaccine in children immunized with acellular or whole-cell vaccine as infants.
Adverse reactions of a pertussis toxoid vaccine in a double-blind placebo-controlled trial.
Aerolysin and pertussis toxin share a common receptor-binding domain.
Aerolysin induces G-protein activation and Ca2+ release from intracellular stores in human granulocytes.
Aerosol infection test for evaluation of pertussis vaccine.
Afamin stimulates osteoclastogenesis and bone resorption via Gi-coupled receptor and Ca2+/calmodulin-dependent protein kinase (CaMK) pathways.
Affinity cross-linked delta-opioid receptor in NG108-15 cells is low molecular weight (25 kDa) and coupled to GTP-binding proteins.
Affinity purification of pancreastatin receptor-Gq/11 protein complex from rat liver membranes.
Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors.
Age increases expression and receptor-mediated activation of G alpha i in human atria.
Age related differences in dynamics of specific memory B cell populations after clinical pertussis infection.
Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases.
Age-dependent alterations of human recombinant GM-CSF effects on human granulocytes.
Age-dependent changes in response of rat prostatic tissues to isoproterenol and forskolin: changes with sexual maturation in function of G proteins.
Age-dependent changes in transmembrane signalling: identification of G proteins in human lymphocytes and polymorphonuclear leukocytes.
Age-related alterations in adenylyl cyclase system of rat hearts.
Age-related alterations in the signal transduction pathways of the elastin-laminin receptor.
Age-related and testicular regression-induced changes in adenosine 3',5'-monophosphate responses in cultured hamster Sertoli cells.
Age-related changes in beta-adrenergic neuroeffector systems in the human heart.
Age-related changes in G proteins in rat aorta.
Age-related differences in antibody avidities to pertussis toxin and filamentous hemagglutinin in a healthy Japanese population.
Age-related differences in patterns of increased Bordetella pertussis antibodies.
Age-related loss of calcitriol stimulation of phosphoinositide hydrolysis in rat skeletal muscle.
Age-related regional sensitivity to pertussis toxin-mediated reduction in GABAB receptor binding in rat brain.
Age-specific long-term course of IgG antibodies to pertussis toxin after symptomatic infection with Bordetella pertussis.
Aggregation of pigment granules in single cultured Xenopus laevis melanophores by melatonin analogues.
Aging and calcitriol regulation of IP3 production in rat skeletal muscle and intestine.
Agmatine induced NO dependent rat mesenteric artery relaxation and its impairment in salt-sensitive hypertension.
Agomelatine modulates calcium signaling through protein kinase C and phospholipase C-mediated mechanisms in rat sensory neurons.
Agonist activation of delta-opioid receptor but not mu-opioid receptor potentiates fetal calf serum or tyrosine kinase receptor-mediated cell proliferation in a cell-line-specific manner.
Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation.
Agonist Activity of the delta-antagonists TIPP and TIPP-psi in cellular models expressing endogenous or transfected delta-opioid receptors.
Agonist and antagonist binding to alpha 2-adrenergic receptors in purified membranes from human platelets. Implications of receptor-inhibitory nucleotide-binding protein stoichiometry.
Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling.
Agonist and inverse agonist activity at the dopamine D3 receptor measured by guanosine 5'--gamma-thio-triphosphate--35S- binding.
Agonist dose-dependent PKA and GRK phosphorylation regulate {beta}2 adrenoceptor coupling to Gi proteins in cardiomyocytes.
Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes.
Agonist interaction with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes.
Agonist interactions with cardiac muscarinic receptors. Effects of Mg2+, guanine nucleotides, and monovalent cations.
Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry.
Agonist occupation of serotonin1A receptors in the rat hippocampus prevents their inactivation by pertussis toxin.
Agonist properties of pindolol at h5-HT1A receptors coupled to mitogen-activated protein kinase.
Agonist receptors and G proteins as mediators of platelet activation.
Agonist stimulation of Na+/K+/Cl- cotransport in rat glomerular mesangial cells. Evidence for protein kinase C-dependent and Ca2+/calmodulin-dependent pathways.
Agonist stimulation of the serotonin1A receptor causes suppression of anoxia-induced apoptosis via mitogen-activated protein kinase in neuronal HN2-5 cells.
Agonist-, antagonist-, and inverse agonist-regulated trafficking of the delta-opioid receptor correlates with, but does not require, G protein activation.
Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways.
Agonist-dependent cannabinoid receptor signalling in human trabecular meshwork cells.
Agonist-dependent delivery of M(2) muscarinic acetylcholine receptors to the cell surface after pertussis toxin treatment.
Agonist-dependent, cholera toxin-catalyzed ADP-ribosylation of pertussis toxin-sensitive G-proteins following transfection of the human alpha 2-C10 adrenergic receptor into rat 1 fibroblasts. Evidence for the direct interaction of a single receptor with two pertussis toxin-sensitive G-proteins, Gi2 and Gi3.
Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s).
Agonist-independent modulation of L-type Ca currents by basal Gs protein activities in single guinea pig ventricular myocytes.
Agonist-independent tonic inhibitory influence of Gi on adenylate cyclase activity in rabbit ventricular myocardium and its removal by pertussis toxin: a role of empty receptor-mediated Gi activation.
Agonist-Induced Activation of Histamine H3 Receptor Signals to Extracellular Signal-Regulated Kinases 1 and 2 through PKC-, PLD- and EGFR-dependent Mechanisms.
Agonist-induced desensitization of human ?3-adrenoceptors expressed in human embryonic kidney cells.
Agonist-induced desensitization, internalization, and phosphorylation of the sst2A somatostatin receptor.
Agonist-induced down-regulation of human 5-HT1A and 5-HT2 receptors in Swiss 3T3 cells.
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
Agonist-induced down-regulation of the angiotensin II receptor in primary cultures of rat hepatocytes.
Agonist-induced GTPgamma35S binding mediated by human 5-HT(2C) receptors expressed in human embryonic kidney 293 cells.
Agonist-induced inhibition of inositol-trisphosphate-activated IK(Ca) in NG108-15 neuroblastoma hybrid cells.
Agonist-induced phosphorylation and desensitization of human m2 muscarinic cholinergic receptors in Sf9 insect cells.
Agonist-induced phosphorylation of somatostatin receptor subtype 1 (sst1). Relationship to desensitization and internalization.
Agonist-induced, G protein-dependent and -independent down-regulation of the mu opioid receptor. The receptor is a direct substrate for protein-tyrosine kinase.
Agonist-induced, GTP-dependent phosphoinositide hydrolysis in postmortem human brain membranes.
Agonist-mediated activation of PLA2 initiates Ca2+ mobilization in intestinal longitudinal smooth muscle.
Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation.
Agonist-mediated tyrosine phosphorylation of isoforms of the shc adapter protein by the delta opioid receptor.
Agonist-selective dynamic compartmentalization of human Mu opioid receptor as revealed by resolutive FRAP analysis.
Agonist-sensitive binding of a photoreactive GTP analog to a G-protein alpha-subunit in membranes of HL-60 cells.
Agonist-specific activation of the beta2-adrenoceptor/Gs-protein and beta2-adrenoceptor/Gi-protein pathway in adult rat ventricular cardiomyocytes.
Agonist-specific down-regulation of the human delta-opioid receptor.
Agonist-stimulated high-affinity GTPase in Dictyostelium membranes.
Agonists activate Gi1 alpha or Gi2 alpha fused to the human mu opioid receptor differently.
Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus.
Agonists for G-protein-coupled receptor 84 (GPR84) alter cellular morphology and motility but do not induce pro-inflammatory responses in microglia.
Agonists of the P2Y(AC)-receptor activate MAP kinase by a ras-independent pathway in rat C6 glioma.
Agouti-related peptide and MC3/4 receptor agonists both inhibit excitatory hypothalamic ventromedial nucleus neurons.
AGS3 and G?i3 Are Concomitantly Upregulated as Part of the Spindle Orientation Complex during Differentiation of Human Neural Progenitor Cells.
AhR Activation by TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) Attenuates Pertussis Toxin-Induced Inflammatory Responses by Differential Regulation of Tregs and Th17 Cells Through Specific Targeting by microRNA.
AKT-independent Reelin signaling requires interactions of heterotrimeric Go and Src.
Alarmin function of cathelicidin antimicrobial peptide LL37 through IL-36? induction in human epidermal keratinocytes.
Albumin endocytosis is regulated by heterotrimeric GTP-binding protein G alpha i-3 in opossum kidney cells.
Aldosterone inhibits apical NHE3 and HCO3- absorption via a nongenomic ERK-dependent pathway in medullary thick ascending limb.
Aldosterone stimulates vacuolar H+-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C dependent pathway.
Aldosterone stimulation of GTP hydrolysis in membranes from renal epithelia.
Alkylation of cysteine 41, but not cysteine 200, decreases the ADP-ribosyltransferase activity of the S1 subunit of pertussis toxin.
All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase.
All species of the genus Bordetella contain genes for pertussis toxin of Bordetella pertussis.
Allele frequencies of Bordetella pertussis virulence-associated genes identified from pediatric patients with severe respiratory infections.
Allopregnanolone activates GABA(A) receptor/Cl(-) channels in a multiphasic manner in embryonic rat hippocampal neurons.
Allosteric interactions at the m1, m2 and m3 muscarinic receptor subtypes.
Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.
Alpha 1 adrenoceptor activation potentiates taurine response mediated by protein kinase C in substantia nigra neurons.
Alpha 1-adrenergic inhibition of the beta-adrenergically activated Cl- current in guinea pig ventricular myocytes.
Alpha 1-adrenergic receptor coupling with phospholipase-C is negatively regulated by protein kinase-C in primary cultures of hypothalamic neurons and glial cells.
Alpha 1-adrenergic receptor mediates arachidonic acid release in spinal cord neurons independent of inositol phospholipid turnover.
Alpha 1-adrenergic receptor-linked guanine nucleotide-binding protein in muscle and kidney epithelial cells.
Alpha 1-adrenergic regulation of TSH-stimulated cyclic AMP accumulation in rat thyroid cells.
Alpha 1-adrenergic signaling in human airway epithelial cells involves inositol lipid and phosphate metabolism.
Alpha 1-adrenergic stimulation of in vitro growth hormone release and cytosolic free Ca2+ in rat somatotrophs.
Alpha 1-adrenoceptor-mediated inhibition of cellular cAMP accumulation in neonatal rat ventricular myocytes.
Alpha 1-adrenoceptors reduce background K+ current in rabbit ventricular myocytes.
Alpha 1B-adrenoceptor-mediated stimulation of Ca2+ mobilization and cAMP accumulation in isolated rat hepatocytes.
Alpha 2 adrenergic receptor subtypes expressed in Chinese hamster ovary cells activate differentially mitogen-activated protein kinase by a p21ras independent pathway.
Alpha 2 adrenoceptor potentiates glycine receptor-mediated taurine response through protein kinase A in rat substantia nigra neurons.
Alpha 2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha 2A-subtype.
Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene.
Alpha 2-adrenergic and muscarinic cholinergic receptors have opposing actions on cyclic AMP levels in SK-N-SH human neuroblastoma cells.
Alpha 2-adrenergic inhibition of Cl- transport by opercular epithelium is mediated by intracellular Ca2+.
Alpha 2-adrenergic inhibition of pancreatic islet glucose utilization is mediated by an inhibitory guanine nucleotide regulatory protein.
Alpha 2-adrenergic receptor stimulation mobilizes intracellular Ca2+ in human erythroleukemia cells.
Alpha 2-adrenergic receptor stimulation of phospholipase A2 and of adenylate cyclase in transfected Chinese hamster ovary cells is mediated by different mechanisms.
Alpha 2-adrenergic receptors activate phospholipase C in renal epithelial cells.
Alpha 2-adrenergic receptors in brown adipose tissue of infant rats--II. Studies on function and regulation.
Alpha 2-adrenergic receptors mediate inhibition of cyclic AMP production in neurons in primary culture.
Alpha 2-adrenergic receptors regulate Na(+)-H+ exchange via a cAMP-dependent mechanism.
Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases.
alpha 2-Adrenoceptors potentiate angiotensin II- and vasopressin-induced renal vasoconstriction in spontaneously hypertensive rats.
Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins.
Alpha 2A adrenergic receptors inhibit cAMP accumulation in embryonic stem cells which lack Gi alpha 2.
Alpha 2A-adrenergic receptor stimulated calcium release is transduced by Gi-associated G(beta gamma)-mediated activation of phospholipase C.
Alpha 2A-adrenoceptors mediate activation of non-selective cation channels via Gi-proteins in human erythroleukaemia (HEL) cells. No evidence for a functional role of imidazoline receptors in modulating calcium.
alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.
Alpha adrenergic receptor subtypes involved in prostaglandin synthesis are coupled to Ca++ channels through a pertussis toxin-sensitive guanine nucleotide-binding protein.
Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels.
Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells.
alpha(2A)-adrenoceptor: G(alphai1) protein-mediated pertussis toxin-resistant attenuation of G(s) coupling to the cyclic AMP pathway.
alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells.
Alpha-1 adrenergic stimulation of 1,4,5-inositol trisphosphate formation in ventricular myocytes.
alpha-1-Adrenergic receptor stimulation causes arachidonic acid release through pertussis toxin-sensitive GTP-binding protein and JNK activation in rabbit aortic smooth muscle cells.
Alpha-2 adrenoceptor mediated changes in aqueous dynamics: effect of pertussis toxin.
Alpha-2 adrenoceptors modulate the somatostatinergic system and G protein levels in the rat hippocampus.
Alpha-2 agonists induce amnesia through activation of the Gi-protein signalling pathway.
Alpha-adrenergic control of volume-regulated Cl- currents in rabbit atrial myocytes. Characterization of a novel ionic regulatory mechanism.
Alpha-adrenergic inhibition of rat pancreatic beta-cell replication and insulin secretion is mediated through a pertussis toxin-sensitive G-protein regulating islet cAMP content.
Alpha-adrenergic receptors regulate human lymphocyte amiloride-sensitive sodium channels.
alpha-Adrenergic-mediated activation of human reconstituted fibrinogen receptor (integrin alphaIIbbeta3) in Chinese hamster ovary cells.
Alpha-adrenoceptor activation of polyphosphoinositide hydrolysis in the rat tail artery.
Alpha-adrenoceptor mediated responses of the cauda epididymis of the guinea-pig.
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, but not N-methyl-D-aspartate, activates mitogen-activated protein kinase through G-protein beta gamma subunits in rat cortical neurons.
Alpha-bag cell peptide inhibits bag cell adenylate cyclase via a GTP-dependent mechanism.
Alpha-cobratoxin inhibits T-type calcium currents through muscarinic M4 receptor and G?-protein ?? subunits-dependent protein kinase A pathway in dorsal root ganglion neurons.
Alpha-fetoprotein contributes to THP-1 cell invasion and chemotaxis via protein kinase and Gi-protein-dependent pathways.
Alpha1 adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells. Role in mitogenesis.
Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages.
Alpha2-adrenergic receptor-mediated Ca2+ influx and release in porcine myometrial cells.
alpha2-Adrenoceptor activation increases calcium channel currents in single vascular smooth muscle cells isolated from human omental resistance arteries.
Alpha2-adrenoceptor regulation of adenylyl cyclase in CHO cells: dependence on receptor density, receptor subtype and current activity of adenylyl cyclase.
alpha2-Adrenoceptor stimulation promotes actin polymerization and focal adhesion in 3T3F442A and BFC-1beta preadipocytes.
Alpha2-adrenoceptor-mediated enhancement of glycine response in rat sacral dorsal commissural neurons.
Alpha2-adrenoceptor-mediated inhibition of cultured sympathetic neurons: changes in alpha2A/D-adrenoceptor-deficient mice.
Alpha2-adrenoceptors couple to inhibition of R-type calcium currents in myenteric neurons.
Alpha2-adrenoceptors in opossum kidney cells couple to stimulation of mitogen-activated protein kinase independently of adenylyl cyclase inhibition.
Alpha2-adrenoreceptor activation inhibits LTP and LTD in the basolateral amygdala: involvement of Gi/o-protein-mediated modulation of Ca2+-channels and inwardly rectifying K+-channels in LTD.
alpha4 Integrin/FN-CS1 mediated leukocyte adhesion to brain microvascular endothelial cells under flow conditions.
Alteration of G protein levels in antigen-challenged guinea pigs.
Alteration of lymphocyte opioid receptors in methadone maintenance subjects.
Alteration of mast cell responsiveness to adenosine by pertussis toxin.
Alteration of the GTP-dependent inhibitory pathway of rat striatal adenylate cyclase by phorbol esters.
Alterations in alpha 1-adrenergic receptor-mediated phosphatidylinositol turnover in hypoxic cardiac myocytes.
Alterations in detergent solubility of heterotrimeric G proteins after chronic activation of G(i/o)-coupled receptors: changes in detergent solubility are in correlation with onset of adenylyl cyclase superactivation.
Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging.
Alterations in G-proteins in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters.
Alterations of cytosolic calcium in LLC-PK1 cells induced by vasopressin and exogenous purines.
Alterations of G protein function in cardiac tissues from streptozotocin-induced chronic diabetic rats.
Alterations of the preproenkephalin system in cardiac hypertrophy and its role in atrioventricular conduction.
Altered activity of the inhibitory guanyl nucleotide-binding component (Ni) induced by pertussis toxin. Uncoupling of Ni from receptor with continued coupling of Ni to the catalytic unit.
Altered adenylyl cyclase responsiveness subsequent to point mutations of Asp 128 in the third transmembrane domain of the delta-opioid receptor.
Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors.
Altered endothelium-dependent and -independent hyperpolarization and endothelium-dependent relaxation in carotid arteries isolated from streptozotocin-induced diabetic rats.
Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi alpha) in spontaneously hypertensive rats.
Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi-proteins) in experimental hepatocellular carcinoma.
Altered guanine nucleoside triphosphate binding to transducin by cholera toxin-catalysed ADP-ribosylation.
Altered phosphatidylinositol breakdown after K-elastin stimulation in PMNLs of elderly.
Altered responses to modulators of guanine nucleotide binding protein activity in endotoxin tolerance.
Altered sinus nodal and atrioventricular nodal function in freely moving mice overexpressing the A1 adenosine receptor.
Altered subcellular signaling in murine peritoneal macrophages upon chronic morphine exposure.
Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cells.
Alternative splicing event modifying ADGRL1/latrophilin-1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways.
Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.
Aluminum-induced mitogenesis in MC3T3-E1 osteoblasts: potential mechanism underlying neoosteogenesis.
Amifostine ameliorates induction of experimental autoimmune encephalomyelitis: Effect on reactive oxygen species/NLRP3 pathway.
Amiloride interacts with guanine nucleotide regulatory proteins and attenuates the hormonal inhibition of adenylate cyclase.
Amino acid-specific ADP-ribosylation. Sensitivity to hydroxylamine of [cysteine(ADP-ribose)]protein and [arginine(ADP-ribose)]protein linkages.
Amino acid-specific ADP-ribosylation: structural characterization and chemical differentiation of ADP-ribose-cysteine adducts formed nonenzymatically and in a pertussis toxin-catalyzed reaction.
Aminooxypentane-RANTES induces CCR3 activation and internalization of CCR3 from the surface of human eosinophils.
Amitriptyline pretreatment preserves the antinociceptive effect of morphine in pertussis toxin-treated rats by lowering CSF excitatory amino acid concentrations and reversing the downregulation of glutamate transporters.
Ammonium decreases human polymorphonuclear leukocyte cytoskeletal actin.
Ammonium triggers calcium elevation in cultured mouse microglial cells by initiating Ca(2+) release from thapsigargin-sensitive intracellular stores.
AMPA receptor activates a G-protein that suppresses a cGMP-gated current.
Amplification of alpha 1D-adrenoceptor mediated contractions in rat aortic rings partially depolarised with KCl.
Amplification of cyclic AMP generation reveals agonistic effects of certain beta-adrenergic antagonists.
Amplification of the rat M2 muscarinic receptor gene by the polymerase chain reaction: functional expression of the M2 muscarinic receptor.
Amygdaloid kindling elicits persistent changes in pertussis toxin-catalyzed ADP-ribosylation.
Amylin (islet amyloid polypeptide) inhibition of insulin release in the perfused rat pancreas: implication of the adenylate cyclase/cAMP system.
Amyloid beta peptides trigger CD47-dependent mast cell secretory and phagocytic responses.
Amyloid beta protein (25-35) phosphorylates MARCKS through tyrosine kinase-activated protein kinase C signaling pathway in microglia.
Amyloid beta protein (25-35) stimulation of phospholipase C in LA-N-2 cells.
Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway.
Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain.
Amyloid-beta precursor protein mediates neuronal toxicity of amyloid beta through Go protein activation.
An abnormal signal transduction pathway in CD4-CD8- double-negative lymph node cells of MRL lpr/lpr mice.
An acellular pertussis vaccine in healthy adults: safety and immunogenicity. Pennridge Pediatric Associates.
An adenosine derivative cooperates with TSH and Graves' IgG to induce Ca2+ mobilization in single human thyroid cells.
An adenosine receptor agonist-induced modulation of TSH-dependent cell growth in FRTL-5 thyroid cells mediated by inhibitory G protein, Gi.
An adhesion-associated agonist from the zona pellucida activates G protein-promoted elevations of internal Ca2+ and pH that mediate mammalian sperm acrosomal exocytosis.
An agonist-induced switch in G protein coupling of the gonadotropin-releasing hormone receptor regulates pulsatile neuropeptide secretion.
An alpha 40 subunit of a GTP-binding protein immunologically related to Go mediates a dopamine-induced decrease of Ca2+ current in snail neurons.
An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs.
An analysis of the occurrence of convulsions and death after childhood vaccination.
An antimicrobial peptide tachyplesin acts as a secondary secretagogue and amplifies lipopolysaccharide-induced hemocyte exocytosis.
An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-?B pathways.
An aplysia dopamine1-like receptor: molecular and functional characterization.
An apoplastic mechanism for short-term effects of rare earth elements at lower concentrations.
An arginine residue is the site of receptor-stimulated, cholera toxin-catalysed ADP-ribosylation of pertussis toxin-sensitive G-proteins.
An autocrine motility factor secreted by the Dunning R-3327 rat prostatic adenocarcinoma cell subtype AT2.1.
An electrophysiological study of excitatory purinergic neuromuscular transmission in longitudinal smooth muscle of chicken anterior mesenteric artery.
An ELISA method to estimate the mono ADP-ribosyltransferase activities: e.g in pertussis toxin and vaccines.
An endogenous inhibitor of the ADP-ribosylation of GTP-binding proteins by pertussis toxin is present in bovine brain.
An enzyme-linked-immunosorbent assay method for detection of immunoglobulins to pertussis toxin.
An essential role for G?(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.
An evaluation of serious neurological disorders following immunization: a comparison of whole-cell pertussis and acellular pertussis vaccines.
An examination of the relationship between mu-opioid antinociceptive efficacy and G-protein coupling using pertussis and cholera toxins.
An excitatory muscarinic response in neonatal rat ventricular myocytes and its modulation by sympathetic innervation.
An fMLP receptor is involved in activation of phagocytosis by hemocytes from specific insect species.
An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity.
An ibotenate-selective metabotropic glutamate receptor mediates protein phosphorylation in cultured hippocampal pyramidal neurons.
An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60.
An improved ELISA system for the measurement of IgG antibodies against pertussis toxin (PT) and filamentous hemagglutinin (FHA) in human sera.
An in vitro assay system as a potential replacement for the histamine sensitisation test for acellular pertussis based combination vaccines.
An international collaborative study of the effect of active pertussis toxin on the modified Kendrick test for acellular pertussis vaccines.
An intracellular guanine nucleotide release protein for G0. GAP-43 stimulates isolated alpha subunits by a novel mechanism.
An Intrinsic gamma-aminobutyric acid (GABA)ergic system in the adrenal cortex: findings from human and rat adrenal glands and the NCI-H295R cell line.
An investigation of Japanese neonatal and maternal antibody status against pertussis.
An investigation of whether agonist-selective receptor conformations occur with respect to M2 and M4 muscarinic acetylcholine receptor signalling via Gi/o and Gs proteins.
An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover.
An M2-like muscarinic receptor enhances a delayed rectifier K+ current in rat sympathetic neurones.
An N-ethylmaleimide-sensitive G-protein modulates Aplysia Ca2+ channels.
An observational study of antibody responses to a primary or subsequent pertussis booster vaccination in Australian healthcare workers.
An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction.
Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.
Analogous IgG subclass response to pertussis toxin in vaccinated children, healthy or affected by whooping cough.
Analyses of secondary structures in DNA by pyrosequencing.
Analyses of the cag pathogenicity island of Helicobacter pylori.
Analysis of adenosine actions on Ca2+ currents and synaptic transmission in cultured rat hippocampal pyramidal neurones.
Analysis of behavior and trafficking of dendritic cells within the brain during toxoplasmic encephalitis.
Analysis of Bordetella pertussis clinical isolates circulating in European countries during the period 1998-2012.
Analysis of Bordetella pertussis pertactin and pertussis toxin types from Queensland, Australia, 1999-2003.
Analysis of Bordetella pertussis populations in European countries with different vaccination policies.
Analysis of Bordetella pertussis virulence gene regulation by use of transcriptional fusions in Escherichia coli.
Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium.
Analysis of delta-opioid receptor activities stably expressed in CHO cell lines: function of receptor density?
Analysis of experimental autoimmune encephalomyelitis induced in F344 rats by pertussis toxin administration.
Analysis of inverse agonism at the delta opioid receptor after expression in Rat 1 fibroblasts.
Analysis of naïve lung CD4 T cells provides evidence of functional lung to lymph node migration.
Analysis of neurogenesis during experimental autoimmune encephalomyelitis reveals pitfalls of bioluminescence imaging.
Analysis of proteins encoded by the ptx and ptl genes of Bordetella bronchiseptica and Bordetella parapertussis.
Analysis of receptor-G protein interactions in permeabilized cells.
Analysis of relative levels of production of pertussis toxin subunits and Ptl proteins in Bordetella pertussis.
Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations.
Analysis of second messenger pathways stimulated by different chemokines acting at the chemokine receptor CCR5.
Analysis of signaling events associated with activation of neutrophil superoxide anion production by eosinophil granule major basic protein.
Analysis of subassemblies of pertussis toxin subunits in vivo and their interaction with the ptl transport apparatus.
Analysis of Swedish Bordetella pertussis isolates with three typing methods: characterization of an epidemic lineage.
Analysis of the In Vivo Transcriptome of Bordetella pertussis during Infection of Mice.
Analysis of the proliferative response to lysophosphatidic acid in primary cultures of mammary epithelium: differences between normal and tumor cells.
Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin.
Analyzing titers of antibodies against bacterial and viral antigens, and bacterial toxoids in the intravenous immunoglobulins utilized in Taiwan.
Anandamide and WIN 55212-2 inhibit cyclic AMP formation through G-protein-coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes.
Anandamide inhibits Fc?RI-dependent degranulation and cytokine synthesis in mast cells through CB2 and GPR55 receptor activation. Possible involvement of CB2-GPR55 heteromers.
Anandamide transport inhibitor AM404 and structurally related compounds inhibit synaptic transmission between rat hippocampal neurons in culture independent of cannabinoid CB1 receptors.
Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase.
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.
Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells.
Anandamide-induced mobilization of cytosolic Ca2+ in endothelial cells.
Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors.
Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent.
Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells.
Anaphylatoxins C5a and C3a induce nuclear factor kappaB activation in human peripheral blood monocytes.
Anaphylaxis and mortality induced by treatment of mice with anti-VLA-4 antibody and pertussis toxin.
Anaphylaxis to a self-peptide in the absence of mast cells or histamine.
Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein.
Anesthetic barbiturates enhance Gs alpha-dependent cyclic AMP production in S49 mouse lymphoma cells.
ANG II AT1 and AT2 receptors both inhibit bFGF-induced proliferation of bovine adrenocortical cells.
Angioedema as a predominant symptom of Bordetella pertussis infection.
Angiogenic activity of human CC chemokine CCL15 in vitro and in vivo.
Angiogenic and Arthritogenic Properties of the Soluble Form of CD13.
Angiogenic factors stimulate mast-cell migration.
Angiogenic Host Defense Peptide AG-30/5C and Bradykinin B2 Receptor Antagonist Icatibant Are G Protein Biased Agonists for MRGPRX2 in Mast Cells.
Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses.
Angiogenin depresses aortic smooth muscle cell cAMP by a pertussis toxin sensitive mechanism.
Angiogenin stimulates endothelial cell prostacyclin secretion by activation of phospholipase A2.
Angiopeptin (BIM23014C) inhibits vascular smooth muscle cell migration in vitro through a G-protein-mediated pathway and is associated with inhibition of adenylyl cyclase and cyclic AMP accumulation.
Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3.
Angiotensin AT(1) receptor phosphorylation and desensitization in a hepatic cell line. Roles of protein kinase c and phosphoinositide 3-kinase.
Angiotensin AT(1)-receptors depolarize neonatal spinal motoneurons and other ventral horn neurons via two different conductances.
Angiotensin AT1 receptors in Clone 9 rat liver cells: Ca2+ signaling and c-fos expression.
Angiotensin blocks substance P release from renal sensory nerves by inhibiting PGE2-mediated activation of cAMP.
Angiotensin II (A-II) steroidogenic refractoriness in Y-1 cells in the presence of A-II receptors negatively coupled to adenylate cyclase.
Angiotensin II activates mitogen-activated protein kinase via protein kinase C and Ras/Raf-1 kinase in bovine adrenal glomerulosa cells.
Angiotensin II activates the ouabain-insensitive Na+-ATPase from renal proximal tubules through a G-protein.
Angiotensin II and acetylcholine differentially activate mobilization of inositol phosphates in Xenopus laevis ovarian follicles.
Angiotensin II and dopamine modulate both cAMP and inositol phosphate productions in anterior pituitary cells. Involvement in prolactin secretion.
Angiotensin II and guanine nucleotides stimulate formation of inositol 1,4,5-trisphosphate and its metabolites in permeabilized adrenal glomerulosa cells.
Angiotensin II AT1 receptor/signaling mechanisms in the biphasic effect of the peptide on proximal tubular Na+,K+-ATPase.
Angiotensin II counteracts the effects of cAMP/PKA on NHE3 activity and phosphorylation in proximal tubule cells.
Angiotensin II directly increases rabbit renal brush-border membrane sodium transport: presence of local signal transduction system.
Angiotensin II effects on the cytosolic free Ca2+ concentration in N1E-115 neuroblastoma cells: kinetic properties of the Ca2+ transient measured in single fura-2-loaded cells.
Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet.
Angiotensin II induces a rapid and transient increase of reactive oxygen species.
Angiotensin II induces diverse signal transduction pathways via both Gq and Gi proteins in liver epithelial cells.
Angiotensin II inhibits calcium and M current channels in rat sympathetic neurons via G proteins.
Angiotensin II inhibits protein kinase A-dependent chloride conductance in heart via pertussis toxin-sensitive G proteins.
Angiotensin II is retained in gonadotrophs of pituitary cell aggregates cultured in serum-free medium but does not mimic the effects of exogenous angiotensins and luteinizing-hormone-releasing hormone on growth hormone release.
Angiotensin II negatively modulates L-type calcium channels through a pertussis toxin-sensitive G protein in adrenal glomerulosa cells.
Angiotensin II phosphorylation of extracellular signal-regulated kinases in rat anterior pituitary cells.
Angiotensin II potentiates agonist-induced 3',5'-cyclic adenosine monophosphate production by cultured bovine adrenal cells through protein kinase C and calmodulin pathways.
Angiotensin II receptor recognized by DuP753 regulates two distinct guanine nucleotide-binding protein signaling pathways.
Angiotensin II receptor subtypes in cultured rat renal mesangial cells.
Angiotensin II receptor-mediated calcium influx in bovine adrenal glomerulosa cells.
Angiotensin II receptor-mediated stimulation of cytosolic-free calcium and inositol phosphates in chick myocytes.
Angiotensin II receptors and inhibitory actions in Leydig cells.
Angiotensin II receptors and mechanisms of action in adrenal glomerulosa cells.
Angiotensin II receptors negatively coupled to adenylate cyclase in rat myocardial sarcolemma. Involvement of inhibitory guanine nucleotide regulatory protein.
Angiotensin II stimulates angiotensinogen synthesis in hepatocytes by a pertussis toxin-sensitive mechanism.
Angiotensin II stimulates early proximal bicarbonate absorption in the rat by decreasing cyclic adenosine monophosphate.
Angiotensin II stimulates protein phosphatase 2A activity in cultured neuronal cells via type 2 receptors in a pertussis toxin sensitive fashion.
Angiotensin II stimulates T-type Ca2+ channel currents via activation of a G protein, Gi.
Angiotensin II stimulates the synthesis of angiotensinogen in hepatocytes by inhibiting adenylylcyclase activity and stabilizing angiotensinogen mRNA.
Angiotensin II stimulates tyrosine phosphorylation of the focal adhesion-associated protein paxillin in aortic smooth muscle cells.
Angiotensin II stimulation of Na-H antiporter activity is cAMP independent in OKP cells.
Angiotensin II stimulation of the stress-activated protein kinases in renal mesangial cells is mediated by the angiotensin AT1 receptor subtype.
Angiotensin II type 1 receptor signals through Raf-1 by a protein kinase C-dependent, Ras-independent mechanism.
Angiotensin II type 1 receptor-mediated activation of Ras in cultured rat vascular smooth muscle cells.
Angiotensin II type 1 receptor-mediated increase in cytosolic Ca(2+) and proliferation in mesothelial cells.
Angiotensin II type 1 receptors stimulate protein synthesis in human cardiac fibroblasts via a Ca2+-sensitive PKC-dependent tyrosine kinase pathway.
Angiotensin II type 2 receptor inhibits epidermal growth factor receptor transactivation by increasing association of SHP-1 tyrosine phosphatase.
Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells.
Angiotensin II type 2 receptor stimulation increases the rate of NG108-15 cell migration via actin depolymerization.
Angiotensin II type 2 receptor stimulation of neuronal delayed-rectifier potassium current involves phospholipase A2 and arachidonic acid.
Angiotensin II type 2 receptor stimulation of neuronal K+ currents involves an inhibitory GTP binding protein.
Angiotensin II type 2 receptor-mediated stimulation of protein phosphatase 2A in rat hypothalamic/brainstem neuronal cocultures.
Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase.
Angiotensin II type 2 receptors stimulate collagen synthesis in cultured vascular smooth muscle cells.
Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule.
Angiotensin II-induced inotropism requires an endocardial endothelium-nitric oxide mechanism in the in-vitro heart of Anguilla anguilla.
Angiotensin II-induced protein tyrosine phosphorylation in neonatal rat cardiac fibroblasts.
Angiotensin II-induced renal vasoconstriction in genetic hypertension.
Angiotensin II-induced stimulation of voltage-dependent Ca2+ currents in an adrenal cortical cell line.
Angiotensin II-mediated activation of L-type calcium channels involves phosphatidylinositol hydrolysis-independent activation of protein kinase C in rat portal vein myocytes.
Angiotensin II-mediated signal transduction events in cystic fibrosis pancreatic duct cells.
Angiotensin II-stimulated induction of sis-inducing factor is mediated by pertussis toxin-insensitive G(q) proteins in cardiac myocytes.
Angiotensin-converting enzyme inhibitors regulate the Na(+)-K+ pump via effects on angiotensin metabolism.
Animal models for pertussis vaccine neurotoxicity.
Annexin-1 mediates TNF-alpha-stimulated matrix metalloproteinase secretion from rheumatoid arthritis synovial fibroblasts.
Anomalous features of human neutrophil activation by influenza A virus are shared by related viruses and sialic acid-binding lectins.
ANP stimulates phospholipase C in cultured RIMCT cells: roles of protein kinases and G protein.
Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action.
Antagonism of contractants and relaxants at the level of intracellular calcium and phosphoinositide turnover in the rat uterus.
Antagonism of LTD4-evoked relaxation in canine renal artery and vein.
Antagonist interaction with the human 5-HT(7) receptor mediates the rapid and potent inhibition of non-G-protein-stimulated adenylate cyclase activity: a novel GPCR effect.
Antagonists of epithelial chloride channels inhibit cAMP synthesis.
Antagonizing the different stages of kappa opioid receptor activation selectively and independently attenuates acquisition and consolidation of associative memories.
Anterior uveitis in murine relapsing experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS).
Anti-adrenergic effect of adenosine on Na(+)-Ca(2+) exchange current recorded from guinea-pig ventricular myocytes.
Anti-IL-6 receptor antibody improves pain symptoms in mice with experimental autoimmune encephalomyelitis.
Anti-IL-6 Receptor Antibody Inhibits Spontaneous Pain at the Pre-onset of Experimental Autoimmune Encephalomyelitis in Mice.
Anti-immunoglobulin pretreatment induces a calcium-mobilization response to the chemotactic agent N-formylmethionylleucylphenylalanine in Daudi lymphoblastoid cells.
Anti-inflammatory Activity of Caspian Cobra (Naja naja oxiana) Snake Venom on the Serum Level of Interleukin-27 and Histopathological Changes in Myelin Oligodendrocyte Glycoprotein-experimental Autoimmune Encephalomyelitisinduced Mice.
Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats.
Anti-Inflammatory Effect of Geniposide on Regulating the Functions of Rheumatoid Arthritis Synovial Fibroblasts via Inhibiting Sphingosine-1-Phosphate Receptors1/3 Coupling G?i/G?s Conversion.
Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin.
Anti-inflammatory effects of the partially purified extract of radix Stephaniae tetrandrae: comparative studies of its active principles tetrandrine and fangchinoline on human polymorphonuclear leukocyte functions.
Anti-inflammatory preconditioning by agonists of adenosine A1 receptor.
Anti-invasive activities of experimental chemotherapeutic agents.
Anti-migratory and anti-invasive effect of somatostatin in human neuroblastoma cells: involvement of Rac and MAP kinase activity.
Anti-myelin antibodies play an important role in the susceptibility to develop proteolipid protein-induced experimental autoimmune encephalomyelitis.
Anti-pertussis antibody kinetics following DTaP-IPV booster vaccination in Norwegian children 7-8 years of age.
Anti-pertussis toxin IgG and anti-filamentous hemagglutinin IgG production in children immunized with pertussis acellular vaccine and comparison of these titers with the sera of pertussis convalescent children.
Anti-proliferative effect of a putative endocannabinoid, 2-arachidonylglyceryl ether in prostate carcinoma cells.
Antibacterial agents and release of periplasmic pertussis toxin from Bordetella pertussis.
Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain.
Antibodies directed against alpha subunits of Gi, Gx/z, GO and GS transducer proteins reduced the morphine withdrawal syndrome in mice.
Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.
Antibodies induced by oral immunization of mice with a recombinant protein produced in tobacco plants harboring Bordetella pertussis epitopes.
Antibodies recognizing protective pertussis toxin epitopes are preferentially elicited by natural infection versus acellular immunization.
Antibodies to
Antibodies to an alpha subunit of skeletal muscle calcium channels regulate parathyroid cell secretion.
Antibodies to Bordetella pertussis adenylate cyclase toxin in neonatal and maternal sera.
Antibodies to filamentous hemagglutinin of Bordetella pertussis and protection against whooping cough in schoolchildren.
Antibodies to pertussis antigens in pediatric health care workers.
Antibodies to the GTP binding protein, Go, antagonize noradrenaline-induced calcium current inhibition in NG108-15 hybrid cells.
Antibodies to the ras gene product inhibit adenylate cyclase and accelerate progesterone-induced cell division in Xenopus laevis oocytes.
Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.
Antibody and cell-mediated immune responses to booster immunization with a new acellular pertussis vaccine in school children.
Antibody binding to cell surface amyloid precursor protein induces neuronal injury by deregulating the phosphorylation of focal adhesion signaling related proteins.
Antibody capture assay reveals bell-shaped concentration-response isotherms for h5-HT(1A) receptor-mediated Galpha(i3) activation: conformational selection by high-efficacy agonists, and relationship to trafficking of receptor signaling.
Antibody decay after immunisation of health-care workers with an acellular pertussis vaccine.
Antibody levels to pertussis toxin in preschool children in a non-vaccinating country (Sweden).
Antibody persistence 2 and 3 years after booster vaccination of adolescents with recombinant acellular pertussis monovalent aPgen or combined TdaPgen vaccines.
Antibody persistence after vaccination of adolescents with monovalent and combined acellular pertussis vaccines containing genetically inactivated pertussis toxin: a phase 2/3 randomised, controlled, non-inferiority trial.
Antibody response from whole-cell pertussis vaccine immunized Brazilian children against different strains of Bordetella pertussis.
Antibody response patterns to Bordetella pertussis antigens in vaccinated (primed) and unvaccinated (unprimed) young children with pertussis.
Antibody response to diphtheria-tetanus-pertussis immunization in preterm infants who receive dexamethasone for chronic lung disease.
Antibody response to pertussis toxin and filamentous haemagglutinin in NIH mice immunized with the International Standard for Pertussis Vaccine.
Antibody response to pertussis toxin in patients with clinical pertussis measured by enzyme-linked immunosorbent assay.
Antibody responses and persistence in the two years after immunization with two acellular vaccines and one whole-cell vaccine against pertussis.
Antibody responses in the serum and respiratory tract of mice following oral vaccination with liposomes coated with filamentous hemagglutinin and pertussis toxoid.
Antibody responses of healthy infants to concurrent administration of a bivalent haemophilus influenzae type b-hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines.
Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK.
Antibody responses to Bordetella pertussis antigens and clinical correlations in elderly community residents.
Antibody responses to individual Bordetella pertussis fimbrial antigens Fim2 or Fim3 following immunisation with five component acellular pertussis vaccine or disease.
Antibody responses to pertussis toxin display different kinetics after clinical Bordetella pertussis infection than after vaccination with an acellular pertussis vaccine.
Antibody-induced activation of beta1 integrin receptors stimulates cAMP-dependent migration of breast cells on laminin-5.
Antibody-mediated inhibition of Bordetella pertussis adenylate-cyclase hemolysin-induced macrophage cytotoxicity is influenced by variations in the bacterial population.
Antibody-mediated neutralization of pertussis toxin-induced mitogenicity of human peripheral blood mononuclear cells.
Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts.
Antidepressants induce profibrotic responses via the lysophosphatidic acid receptor LPA1.
Antiendothelial cell antibodies mediate enhanced leukocyte adhesion to cytokine-activated endothelial cells through a novel mechanism requiring cooperation between Fc{gamma}RIIa and CXCR1/2.
Antigen receptor-mediated protein tyrosine kinase activity is regulated by a pertussis toxin-sensitive G protein.
Antigenic divergence of Bordetella pertussis isolates in Taiwan.
Antigenic divergence suggested by correlation between antigenic variation and pulsed-field gel electrophoresis profiles of Bordetella pertussis isolates in Japan.
Antigenic heterogeneity in subunit S1 of pertussis toxin.
Antigenic variants in Bordetella pertussis strains isolated from vaccinated and unvaccinated children.
Antiinflammatory effects in experimental meningitis of prokaryotic peptides that mimic selectins.
Antilipolytic effect of calcium-sensing receptor in human adipocytes.
Antilipolytic effects of insulin and adenylate cyclase inhibitors on isolated human fat cells.
Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability.
Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells.
Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines.
Antimigraine drug, zolmitriptan, inhibits high-voltage activated calcium currents in a population of acutely dissociated rat trigeminal sensory neurons.
Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts.
Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: comparison with conventional Fcgamma receptor ligation.
Antinociception following application of DAMGO to the basolateral amygdala results from a direct interaction of DAMGO with Mu opioid receptors in the amygdala.
Antinociceptive action of myricitrin: involvement of the K+ and Ca2+ channels.
Antinociceptive properties of the new alkaloid, cis-8, 10-di-N-propyllobelidiol hydrochloride dihydrate isolated from Siphocampylus verticillatus: evidence for the mechanism of action.
Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase.
Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts.
Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5.
Antiproliferative signaling of luteinizing hormone-releasing hormone in human endometrial and ovarian cancer cells through G protein alpha(I)-mediated activation of phosphotyrosine phosphatase.
Antipsychotics with inverse agonist activity at the dopamine D3 receptor.
Antisecretory effects of somatostatin and vasopressin in the rat colon descendens in vitro.
Antisense oligodeoxynucleotides to GS protein alpha-subunit sequence accelerate differentiation of fibroblasts to adipocytes.
Antisense oligonucleotides against receptor kinase GRK2 disrupt target selectivity of beta-adrenergic receptors in atrial myocytes.
Antitoxin in human pertussis immune globulins.
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines.
Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein.
Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells.
Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanisms.
Apelin is necessary for the maintenance of insulin sensitivity.
Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells.
Apelin-13 enhances arcuate POMC neuron activity via inhibiting M-current.
Apelin-13 upregulates Egr-1 expression in rat vascular smooth muscle cells through the PI3K/Akt and PKC signaling pathways.
Apical and basolateral effects of PTH in OK cells: transport inhibition, messenger production, effects of pertussis toxin, and interaction with a PTH analog.
Apical localization of the alpha subunit of GTP-binding protein Go in choroidal and ciliated ependymocytes.
Aplysia synaptosomes. I. Preparation and biochemical and morphological characterization of subcellular membrane fractions.
Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation.
Apomorphine- and oxytocin-induced penile erection and yawning in male rats: effect of pertussis toxin.
Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density.
Appearance of Fim3 and ptxP3-Bordetella pertussis strains, in two regions of Sweden with different vaccination programs.
Application of xCELLigence real-time cell analysis to the microplate assay for pertussis toxin induced clustering in CHO cells.
Approaches to the control of acellular pertussis vaccines.
Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse.
Arachidonic acid as a second messenger for hypotonicity-induced calcium transients in rat IMCD cells.
Arachidonic acid as a second messenger. Interactions with a GTP-binding protein of human neutrophils.
Arachidonic acid for loading induced prostacyclin and prostaglandin E(2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A(2).
Arachidonic acid inhibits hormone-stimulated cAMP accumulation in the medullary thick ascending limb of the rat kidney by a mechanism sensitive to pertussis toxin.
Arachidonic acid mediates interferon-gamma-induced sphingomyelin hydrolysis and monocytic marker expression in HL-60 cell line.
Arachidonic acid metabolism in isolated pancreatic islets. VI. Carbohydrate insulin secretagogues must be metabolized to induce eicosanoid release.
Arachidonic acid release from rat Leydig cells: the involvement of G protein, phospholipase A2 and regulation of cAMP production.
Arachidonic acid-induced mobilization of calcium in human neutrophils: evidence for a multicomponent mechanism of action.
Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors.
Are GABAB receptors involved in the pharmacological effects of ethanol?
Are murine marginal-zone macrophages the splenic white pulp analog of high endothelial venules?
Are several G proteins involved in the different effects of endothelin-1 in mouse striatal astrocytes?
Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B.
Arsenic activates endothelin-1 Gi protein-coupled receptor signaling to inhibit stem cell differentiation in adipogenesis.
Arsenic requires sphingosine-1-phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling.
Arsenic-stimulated lipolysis and adipose remodeling is mediated by G-protein-coupled receptors.
Artocarpol A stimulation of superoxide anion generation in neutrophils involved the activation of PLC, PKC and p38 mitogen-activated PK signaling pathways.
Asbestos-induced activation of the respiratory burst in rabbit neutrophils.
Ascaris suum-derived products induce human neutrophil activation via a G protein-coupled receptor that interacts with the interleukin-8 receptor pathway.
Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells.
Asiasari radix inhibits immunoglobulin E production on experimental models in vitro and in vivo.
Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages.
Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils.
Assay of Bordetella pertussis heat-labile toxin with human embryonic lung cells.
Assay of pertussis vaccine reactivity factors by measurement of the paw swelling response, endotoxin and histamine-sensitizing factor.
Assays for Determining Pertussis Toxin Activity in Acellular Pertussis Vaccines.
Assays for G-protein-coupled receptor signaling using RGS-insensitive Galpha subunits.
Assembly and sealing of tight junctions: possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin.
Assembly dynamics of actin in adherent human neutrophils.
Assessing the reactogenicity of Tdap vaccine administered during pregnancy and antibodies to Bordetella pertussis antigens in maternal and cord sera of Thai women.
Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells.
Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes.
Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity.
Assessment of IgA anti-PT and IgG anti-ACT reflex testing to improve Bordetella pertussis serodiagnosis in recently vaccinated subjects.
Assessment of IgG avidity against pertussis toxin and filamentous hemagglutinin via an adapted enzyme-linked immunosorbent assay (ELISA) using ammonium thiocyanate.
Assessment of mechanisms involved in antinociception caused by sesquiterpene polygodial.
Assessment of the extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model.
Assessment of the immunogenicity and reactogenicity of a quadrivalent diphtheria, tetanus, acellular pertussis and hepatitis B (DTPa-HBV) vaccine administered in a single injection with Haemophilus influenzae type b conjugate vaccine, to infants at 2, 4 and 6 months of age.
Assignment of functional domains involved in ADP-ribosylation and B-oligomer binding within the carboxyl terminus of the S1 subunit of pertussis toxin.
Association Between Third-Trimester Tdap Immunization and Neonatal Pertussis Antibody Concentration.
Association of a solubilized prostaglandin E2 receptor from renal medulla with a pertussis toxin-reactive guanine nucleotide regulatory protein.
Association of guinea pig lung bombesin receptors with pertussis toxin-sensitive guanine nucleotide binding proteins.
Association of heterotrimeric G(i) with the insulin-like growth factor-I receptor. Release of G(betagamma) subunits upon receptor activation.
Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis.
Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.
Association of ligand-receptor complexes with actin filaments in human neutrophils: a possible regulatory role for a G-protein.
Association of Pertussis Toxin with Severe Pertussis Disease.
Association of Routine Infant Vaccinations With Antibody Levels Among Preterm Infants.
Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin.
Association of two pertussis toxin-sensitive G-proteins with the D2-dopamine receptor from bovine striatum.
Astrocyte mGlu(2/3)-mediated cAMP potentiation is calcium sensitive: studies in murine neuronal and astrocyte cultures.
Astrocytes are target cells for endothelins and sarafotoxin.
Astrocytes possess prostaglandin F2 alpha receptors coupled to phospholipase C.
Asymmetric distribution of muscarinic acetylcholine receptors in Madin-Darby canine kidney cells.
Asymmetrical distribution of G-proteins among the apical and basolateral membranes of rat enterocytes.
Atherogenic lipoproteins enhance mesangial cell expression of platelet-derived growth factor: role of protein tyrosine kinase and cyclic AMP-dependent protein kinase A.
ATP acting on P2Y receptors triggers calcium mobilization in primary cultures of rat neurohypophysial astrocytes (pituicytes).
ATP activates the potassium channel and enhances cytosolic Ca2+ release via a P2Y purinoceptor linked to pertussis toxin-insensitive G-protein in brain artery endothelial cells.
ATP and A1 adenosine receptor agonists mobilize intracellular calcium and activate K+ and Cl- currents in normal and cystic fibrosis airway epithelial cells.
ATP and adenosine prevent via different pathways the activation of caspases in apoptotic AKR-2B fibroblasts.
ATP and G proteins affect the runup of the Ca2+ current in bovine chromaffin cells.
ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of inositol 1,4,5-trisphosphate in a smooth muscle cell line.
ATP causes release of intracellular Ca2+ via the phospholipase C beta/IP3 pathway in astrocytes from the dorsal spinal cord.
ATP increases extracellular dopamine level through stimulation of P2Y purinoceptors in the rat striatum.
ATP inhibits glutamate synaptic release by acting at P2Y receptors in pyramidal neurons of hippocampal slices.
ATP inhibits the hydrosmotic effect of AVP in rabbit CCT: evidence for a nucleotide P2u receptor.
ATP modulation of calcium channels in chromaffin cells.
ATP priming of macrophage-derived chemokine responses in CHO cells expressing the CCR4 receptor.
ATP produces potassium currents via P3 purinoceptor in the follicle cell layer of Xenopus oocytes.
ATP receptor regulation of adenylate cyclase and protein kinase C activity in cultured renal LLC-PK1 cells.
ATP regulates muscarine-sensitive potassium current in dissociated bull-frog primary afferent neurones.
ATP shortens atrial action potential duration in the dog: role of adenosine, the vagus nerve, and G protein.
ATP stimulates Na+-glucose cotransporter activity via cAMP and p38 MAPK in renal proximal tubule cells.
ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin-sensitive guanine nucleotide-binding protein coupled to phospholipase C.
ATP stimulates sympathetic transmitter release via presynaptic P2X purinoceptors.
ATP- and EGF-stimulated phosphatidulinositol synthesis by two different pathways, phospholipase D and diacylglycerol kinase, in A-431 epidermoid carcinoma cells.
ATP-evoked increase in intracellular calcium via the P2Y receptor in proliferating bovine trophoblast cells.
ATP-evoked inositol phosphates formation through activation of P2U purinergic receptors in cultured astrocytes: regulation by PKC subtypes alpha, delta, and theta.
ATP-evoked potassium currents in rat striatal neurons are mediated by a P2 purinergic receptor.
ATP-induced arachidonic acid release in cultured astrocytes is mediated by Gi protein coupled P2Y1 and P2Y2 receptors.
ATP-induced Ca2+ influx is regulated via a pertussis toxin-sensitive mechanism in a PC12 cell clone.
ATP-induced calcium transient in cultured rat aortic smooth muscle cells.
ATP-induced cytoplasmic [Ca2+] increases in isolated cochlear outer hair cells. Involved receptor and channel mechanisms.
ATP-induced rise in apamin-sensitive Ca(2+)-dependent K+ conductance in adult rat hepatocytes.
ATP-induced secretion in PC12 cells and photoaffinity labeling of receptors.
Atrial natriuretic factor effects on cyclic nucleotides in a human renal cell line.
Atrial natriuretic factor increases cyclic GMP and cyclic AMP levels in a directly photosensitive pineal organ.
Atrial natriuretic factor intracellular signaling in the rat submandibular gland.
Atrial natriuretic factor negatively modulates secretin intracellular signaling in the exocrine pancreas.
Atrial natriuretic factor reduces cyclic adenosine monophosphate content of human fibroblasts by enhancing phosphodiesterase activity.
Atrial natriuretic factor stimulates migration by human neutrophils.
Atrial natriuretic peptide (ANP)-induced inhibition of glucagon secretion: mechanism of action in isolated rat pancreatic islets.
Atrial natriuretic peptide clearance receptor participates in modulating endothelial permeability.
Atrial natriuretic peptide inhibits iodide uptake and thyroglobulin messenger ribonucleic acid expression in cultured bovine thyroid follicles.
Atrial natriuretic peptide inhibits the actions of FSH and forskolin in meiotic maturation of pig oocytes via different signalling pathways.
Atrial natriuretic peptide modulates alveolar type 2 cell adenylyl and guanylyl cyclases and inhibits surfactant secretion.
Atrial natriuretic peptide modulates the hyperpolarization-activated current (If) in human atrial myocytes.
Atrial natriuretic peptide-C receptor-induced attenuation of adenylyl cyclase signaling activates phosphatidylinositol turnover in A10 vascular smooth muscle cells.
Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.
Attenuated Bordetella pertussis Vaccine Candidate BPZE1 Promotes Human Dendritic Cell CCL21-Induced Migration and Drives a Th1/Th17 Response.
Attenuated Bordetella pertussis: new live vaccines for intranasal immunisation.
Attenuation of changes in G(i)-proteins and adenylyl cyclase in heart failure by an ACE inhibitor, imidapril.
Attenuation of chick heart adenylate cyclase by muscarinic receptors after pertussis toxin treatment.
Attenuation of muscarinic cholinergic inhibition by islet-activating protein in the heart.
Attenuation of parasite cAMP levels in T. cruzi-host cell membrane interactions in vitro.
Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells.
Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells.
Attenuation of the low-density-lipoprotein-activated phosphoinositide signalling system by calcium blockers in human lymphocytes.
Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1.
Augmentation of calcium channel currents in response to G protein activation by GTP gamma S in chick sensory neurons.
Augmentation of glucose induced insulin secretion by pertussis vaccine, phentolamine and benextramine: involvement of mechanisms additional to prevention of the inhibitory actions of catecholamines in rats.
Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbetagamma subunit-independent manner.
Augmentation of the antibody response by antigen-specific glycosylation-enhancing factor.
Augmentation of tumor necrosis factor-alpha-induced monocytic differentiation of a myelomonocytic leukemia (WEHI-3B JCS) by pertussis toxin.
Augmented glucose-induced insulin release in mice lacking G(o2), but not G(o1) or G(i) proteins.
Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309.
Autocrine biological effects of glycosyl inositol phosphate produced by reconstituted pig thyroid follicles: role of pertussis toxin sensitive G proteins.
Autocrine enhancement of leukotriene synthesis by endogenous leukotriene B4 and platelet-activating factor in human neutrophils.
Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1.
Autocrine motility factor and its receptor: role in cell locomotion and metastasis.
Autocrine motility factor is a growth factor.
Autocrine motility factor stimulates a three-fold increase in inositol trisphosphate in human melanoma cells.
Autocrine Regulation of Re-Epithelialization After Wounding by Chemokine Receptors CCR1, CCR10, CXCR1, CXCR2, and CXCR3.
Autoimmune experimental orchitis and chronic glomerulonephritis with end stage renal disease are controlled by Cgnz1 for susceptibility to end organ damage.
Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels.
Autonomic regulation of cardiac chloride current.
Autonomic regulation of delayed rectifier K+ current in mammalian heart involves G proteins.
Autoreactive T cells promote post-traumatic healing in the central nervous system.
Autoreceptor-induced inhibition of neuropeptide Y release from PC-12 cells is mediated by Y2 receptors.
Autoreceptor-mediated purinergic and cholinergic inhibition of motor nerve terminal calcium currents in the rat.
Autoregulation of acute progesterone and adenosine 3',5'-monophosphate responses to follicle-stimulating hormone (FSH) in porcine granulosa cells: effects of FSH, cholera toxin, forskolin, and pertussis toxin.
Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia.
Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells.
Auxin-dependent cell division and cell elongation. 1-Naphthaleneacetic acid and 2,4-dichlorophenoxyacetic acid activate different pathways.
Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis.
B cell differentiation factor-induced B cell maturation: regulation via reduction in cAMP.
B cell differentiation factor-induced human B cell maturation: stimulation of intracellular calcium release.
B- and T-cell responses to the mycobacterium surface antigen PstS-1 in the respiratory tract and adjacent tissues. Role of adjuvants and routes of immunization.
B-cell responses after intranasal vaccination with the novel attenuated Bordetella pertussis vaccine strain BPZE1 in a randomized phase I clinical trial.
B-oligomer of pertussis toxin inhibits HIV-1 LTR-driven transcription through suppression of NF-kappaB p65 subunit activity.
B1 and B2 kinin receptors on cultured rabbit superior mesenteric artery smooth muscle cells: receptor-specific stimulation of inositol phosphate formation and arachidonic acid release by des-Arg9-bradykinin and bradykinin.
Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice.
Bacteria and their toxins tamed for immunotherapy.
Bacterial ADP-ribosylating toxins: form, function, and recombinant vaccine development.
Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells.
Bacterial secrets of secretion: EuroConference on the biology of type IV secretion processes.
Bacterial toxin modulation of the eukaryotic cell cycle: are all cytolethal distending toxins created equally?
Bacterial toxins affect early events of T lymphocyte activation.
Bacterial toxins: potential weapons against HIV infection.
Bacterial type AB? enterotoxins--structure, function and mechanism of action.
Baculovirus-expressed recombinant human zona pellucida glycoprotein-B induces acrosomal exocytosis in capacitated spermatozoa in addition to zona pellucida glycoprotein-C.
Basal levels of adenosine modulate mGluR5 on rat hippocampal astrocytes.
Basic fibroblast growth factor-stimulated endothelial cell movement is mediated by a pertussis toxin-sensitive pathway regulating phospholipase A2 activity.
Basolateral localization and transcytosis of gonadotropin and thyrotropin receptors expressed in Madin-Darby canine kidney cells.
Basophil activation through ASGM1 stimulation triggers PAF release and anaphylaxis-like shock in mice.
Behavioral Conditioning of Immune Responses with Cyclosporine A in a Murine Model of Experimental Autoimmune Uveitis.
Beneficial role of simvastatin in experimental autoimmune myositis.
Berberine possesses muscarinic agonist-like properties in cultured rodent cardiomyocytes.
beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf.
Beta 2-adrenergic receptor signaling acts via NO release to mediate ACh-induced activation of ATP-sensitive K+ current in cat atrial myocytes.
beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes.
Beta 3- and alpha1-adrenergic Erk1/2 activation is Src- but not Gi-mediated in Brown adipocytes.
Beta adrenergic modulation of cardiac rhythm in a rat model of altered sympathetic neural development.
Beta adrenergic receptor activation attenuates the generation of inositol phosphates in the pregnant rat myometrium. Correlation with inhibition of Ca++ influx, a cAMP-independent mechanism.
Beta gamma subunits of GTP-binding proteins inhibit muscarinic receptor stimulation of phospholipase C.
Beta gamma-mediated enhancement of corticotropin-releasing hormone-stimulated adenylyl cyclase activity by activation of gamma-aminobutyric acid(B) receptors in membranes of rat frontal cortex.
Beta(2)-Adrenergic activation increases glycogen synthesis in L6 skeletal muscle cells through a signalling pathway independent of cyclic AMP.
Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i).
Beta(2)-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for G(s)/G(i) switching.
Beta(2)-adrenergic receptors potentiate glucocorticoid receptor transactivation via G protein beta gamma-subunits and the phosphoinositide 3-kinase pathway.
Beta(2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats.
Beta(3)-mediated engulfment of apoptotic tumor cells by dendritic cells is dependent on CAMKII: inhibition by HIV-1 Tat.
Beta-adrenergic and cholinergic modulation of inward rectifier K+ channel function and phosphorylation in guinea-pig ventricle.
beta-adrenergic and cholinergic modulation of the inwardly rectifying K+ current in guinea-pig ventricular myocytes.
Beta-adrenergic and somatostatin receptors regulate Na-H exchange independent of cAMP.
Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart.
beta-adrenergic modulation of maxi-K channels in vascular smooth muscle via Gi through a membrane-delimited pathway.
Beta-adrenergic modulation of Na-K pump activity in young and adult canine cardiac Purkinje fibers.
beta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-Arrestin 1-mediated pathway.
Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice.
Beta-adrenergic receptor-G protein-adenylate cyclase complex in experimental canine congestive heart failure produced by rapid ventricular pacing.
Beta-adrenergic regulation of cyclic AMP synthesis in cultured human syncytiotrophoblast.
beta-Adrenergic-responsive activation of extracellular signal-regulated protein kinases in salivary cells: role of epidermal growth factor receptor and cAMP.
Beta-adrenoceptor mediated signal transduction in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters.
Beta-adrenoceptor, vasoactive intestinal polypeptide (VIP) and neuropeptide tyrosine (NPY) receptors functionally coupled to adenylate cyclase in the human neuroblastoma SK-N-MC cell line.
Beta-adrenoceptor-linked signal transduction in ischemic-reperfused heart and scavenging of oxyradicals.
Beta-adrenoceptor-mediated vascular relaxation in spontaneously hypertensive rats.
Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system.
beta-Amyloid peptide, substance P, and SEC receptor ligand activate cytoplasmic Ca2+ in neutrophil-like HL-60 cells: effect of chemotactic peptide antagonist BocMLF.
beta-Amyloid-induced IL-1 beta release from an activated human monocyte cell line is calcium- and G-protein-dependent.
Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis.
beta-Arrestin recruitment assay for the identification of agonists of the sphingosine 1-phosphate receptor EDG1.
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
Beta-arrestin2 enhances beta2-adrenergic receptor-mediated nuclear translocation of ERK.
Beta-chemokine TCA3 binds to and activates rat vascular smooth muscle cells.
Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
Beta1-adrenoceptors in rat anterior pituitary may be constitutively active. Inverse agonism of CGP 20712A on basal 3',5'-cyclic adenosine 5'-monophosphate levels.
beta2-Adrenergic signaling in human heart: shift from the cyclic AMP to the arachidonic acid pathway.
Beta3-adrenoceptor in the eel (Anguilla anguilla) heart: negative inotropy and NO-cGMP-dependent mechanism.
Beta3-adrenoceptors modulate left ventricular relaxation in the rat heart via the NO-cGMP-PKG pathway.
betagamma dimers derived from Go and Gi proteins contribute different components of adrenergic inhibition of Ca2+ channels in rat sympathetic neurones.
betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption.
Betagamma subunits of G(i/o) suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced.
Betagamma subunits of pertussis toxin-sensitive G proteins mediate A1 adenosine receptor agonist-induced activation of phospholipase C in collaboration with thyrotropin. A novel stimulatory mechanism through the cross-talk of two types of receptors.
bFGF activates endothelial Ca2+-activated K+ channels involving G-proteins and tyrosine kinases.
Biased ?-opioid receptor agonists diversely regulate lateral mobility and functional coupling of the receptor to its cognate G proteins.
Bicarbonate induces sensitization of cyclic AMP accumulation by intact 1321N1 human astrocytoma cells.
Bidirectional modulation of exocytosis by angiotensin II involves multiple G-protein-regulated transduction pathways in chromaffin cells.
Bilateral ureteral obstruction alters levels of the G-protein subunits G alpha s and G alpha q/11.
Bile acids regulate hepatic gluconeogenic genes and FXR via G-alpha-i protein coupled receptor(s) and the AKT pathway.
Bimodal acute effects of A1 adenosine receptor activation on Na+/H+ exchanger 3 in opossum kidney cells.
Bimodal regulation of cyclic AMP by muscarinic receptors. Involvement of multiple G proteins and different forms of adenylyl cyclase.
Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells.
Binding interaction of gamma aminobutyric acid A and B receptors in cell culture.
Binding kinetics of delta opioid receptors differ for microsomal and synaptic sites.
Binding of A1 adenosine receptor ligand [3H]8-cyclopentyl-1,3-dipropylxanthine in coronary smooth muscle.
Binding of ATP by pertussis toxin and isolated toxin subunits.
Binding of IgG containing immune complexes to human neutrophil Fc gamma RII and Fc gamma RIII induces actin polymerization by a pertussis toxin-insensitive transduction pathway.
Binding of NAD+ to pertussis toxin.
Binding of pertussis toxin to eucaryotic cells and glycoproteins.
Binding of pertussis toxin to lipid vesicles containing glycolipids.
Binding of the cytosolic p200 protein to Golgi membranes is regulated by heterotrimeric G proteins.
Binding of the non-typeable Haemophilus influenzae lipooligosaccharide to the PAF receptor initiates host cell signalling.
Binding, coupling, and mRNA subtype heterogeneity of alpha 1-adrenergic receptors in cultured human RPE.
Biochemical analysis of mutations at tyrosine-98 of the S1 subunit of pertussis toxin.
Biochemical and biological activities of recombinant S1 subunit of pertussis toxin.
Biochemical and functional characterization of high-affinity urotensin II receptors in rat cortical astrocytes.
Biochemical and immunochemical localization of GTP-binding proteins in the rat ileal enterocyte.
Biochemical and physical analyses of newly synthesized muscarinic acetylcholine receptors in cultured embryonic chicken cardiac cells.
Biochemical demonstration of mu-opioid receptor association with Gsalpha: enhancement following morphine exposure.
Biochemical discrimination of the predominant pertussis toxin substrate of rabbit neutrophils from brain Gi and Go: isoelectric focusing improves resolution of pertussis toxin substrates.
Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor.
Biochemical evidence for somatostatin receptors in murine neuroblastoma clone N1E-115.
Biochemical investigation of cell motile activity in rheumatoid synovial fluid.
Biochemical properties of pertussis toxin.
Biologic activities of the beta-chemokine TCA3 on neutrophils and macrophages.
Biological actions of the free acid of hepoxilin A3 on human neutrophils.
Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells.
Biological basis and possible physiological implications of melatonin receptor-mediated signaling in the rat epididymis.
Biologically active sequence (KDI) mediates the neurite outgrowth function of the gamma-1 chain of laminin-1.
Biosensing with G-protein coupled receptor systems.
Biosynthesis and functions of leukotriene C4.
Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins.
Biosynthesis of somatostatin in canine fundic D cells.
Biphasic actions of prostaglandin E(2) on the renal afferent arteriole : role of EP(3) and EP(4) receptors.
Biphasic alterations of cAMP levels and inhibition of norepinephrine release in iris-ciliary body by bremazocine.
Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.
Biphasic dose-response curve to muscarine on the rat superior cervical ganglion.
Biphasic dose-response curves to arecoline in rat atria-mediation by a single promiscuous receptor or two receptor subtypes?
Biphasic effect of cAMP-elevating agents on ICAM-1 expression stimulated by retinoic acid and interferon gamma.
Biphasic effect of interleukin-1 beta on arginine vasopressin-induced cellular cyclic adenosine monophosphate production in cultured rat renal papillary collecting tubule cells.
Biphasic effects of cannabinoids on acetylcholine release in the hippocampus: site and mechanism of action.
Biphasic effects of carbachol on stimulated cAMP accumulation in mouse parotid acini.
Biphasic Erk1/2 activation sequentially involving Gs and Gi signaling is required in beta3-adrenergic receptor-induced primary smooth muscle cell proliferation.
Biphasic kinetics of inositol 1,4,5-trisphosphate accumulation in gastrin-stimulated parietal cells. Effects of pertussis toxin and extracellular calcium.
Biphasic modulation of intracellular Ca2+ concentration by interleukin-1beta in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase.
Biphasic modulation of voltage-dependent currents of retinal cones by cannabinoid CB1 receptor agonist WIN 55212-2.
Biphasic regulation of paracellular permeability in human cervical cells by two distinct nucleotide receptors.
Biphasic response to human galanin of extracellular acidification in human Bowes melanoma cells.
Biphasic, opposing modulation of cloned neuronal alpha1E Ca channels by distinct signaling pathways coupled to M2 muscarinic acetylcholine receptors.
Bitter tastants induce relaxation of rat thoracic aorta precontracted with high K(+).
Bitter taste receptors as targets for tocolytics in preterm labor therapy.
Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling.
Block of light responses of salamander rods by pertussis toxin and reversal by nicotinamide.
Blockade by pertussis toxin of the opioid effect on guinea pig ileum. Contractility and electrophysiological neuronal recording.
Blockade of a late inhibitory postsynaptic potential in hippocampal CA3 neurons in vitro reveals a late depolarizing potential that is augmented by pentobarbital.
Blockade of Ca2+-activated K+ channels inhibits proliferation of human endothelial cells induced by basic fibroblast growth factor.
Blockade of endothelial Gi protein enhances early engraftment in intraportal cell transplant to mouse liver.
Blockade of Gi/o proteins modifies electrical activity of S-myenteric neurons from guinea-pig ileum.
Blockade of K+ channels induced by AMPA/kainate receptor activation in mouse oligodendrocyte precursor cells is mediated by Na+ entry.
Blockade of morphine analgesia by both pertussis and cholera toxins in the periaqueductal gray and locus coeruleus.
Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation.
Blockage of amyloid beta peptide-induced cytosolic free calcium by fullerenol-1, carboxylate C60 in PC12 cells.
Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5.
Blood mononuclear cell production of TNF-alpha and IL-8: engagement of different signal transduction pathways including the p42 MAP kinase pathway.
Blood- and skin-derived monocytes/macrophages respond to C3a but not to C3a(desArg) with a transient release of calcium via a pertussis toxin-sensitive signal transduction pathway.
Blood-brain barrier disruption and lesion localisation in experimental autoimmune encephalomyelitis with predominant cerebellar and brainstem involvement.
Bombesin activation of phospholipase C beta 1 in rat acinar pancreatic cells involves the pertussis toxin-sensitive G alpha i3 protein.
Bombesin and glucocorticoids stimulate human breast cancer cells to produce endothelin, a paracrine mitogen for breast stromal cells.
Bombesin and neuromedin B stimulate the activation of p42(mapk) and p74(raf-1) via a protein kinase C-independent pathway in Rat-1 cells.
Bombesin and thrombin affect discrete pools of intracellular calcium through different G-proteins.
Bombesin enhancement of cAMP accumulation in Swiss 3T3 cells: evidence of a dual mechanism of action.
Bombesin induces a reduction of somatostatin inhibition of adenylyl cyclase activity, Gi function, and somatostatin receptors in rat exocrine pancreas.
Bombesin, neuromedin B and neuromedin C interact with a common rat pancreatic phosphoinositide-coupled receptor, but are differentially regulated by guanine nucleotides.
Bombyx adipokinetic hormone receptor activates extracellular signal-regulated kinase 1 and 2 via G protein-dependent PKA and PKC but ?-arrestin-independent pathways.
Bone Gla protein messenger ribonucleic acid is regulated by both 1,25-dihydroxyvitamin D3 and 3',5'-cyclic adenosine monophosphate in rat osteosarcoma cells.
Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells.
Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE responses against pertussis toxin but not against common allergens.
Booster response to acellular pertussis vaccine in children primed with acellular or whole cell vaccines.
Boosting Teenagers With Acellular Pertussis Vaccines Containing Recombinant or Chemically Inactivated Pertussis Toxin: A Randomized Clinical Trial.
Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen.
Bordetella adenylate cyclase: host toxicity and diagnostic utility.
Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor.
Bordetella parapertussis and Bordetella bronchiseptica contain transcriptionally silent pertussis toxin genes.
Bordetella pertussis adenylate cyclase: effects of affinity-purified adenylate cyclase on human polymorphonuclear leukocyte functions.
Bordetella pertussis adenylate cyclase: isolation and purification by calmodulin-sepharose 4B chromatography.
Bordetella pertussis and Bordetella parapertussis infection in an Austrian pediatric outpatient clinic.
Bordetella pertussis and Bordetella parapertussis: two immunologically distinct species.
Bordetella pertussis and vaccination: the persistence of a genetically monomorphic pathogen.
Bordetella pertussis autoregulates pertussis toxin production through the metabolism of cysteine.
Bordetella pertussis diagnosis in children under five years of age in the Regional Hospital of Cajamarca, Northern Peru.
Bordetella pertussis from functional genomics to intranasal vaccination.
Bordetella pertussis induces apoptosis in macrophages: role of adenylate cyclase-hemolysin.
Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity.
Bordetella pertussis infection in mice: correlation of specific antibodies against two antigens, pertussis toxin, and filamentous hemagglutinin with mouse protectivity in an intracerebral or aerosol challenge system.
Bordetella pertussis infection in paediatric healthcare workers.
Bordetella pertussis infection of human respiratory epithelial cells up-regulates intercellular adhesion molecule-1 expression: role of filamentous hemagglutinin and pertussis toxin.
Bordetella pertussis infection of primary human monocytes alters HLA-DR expression.
Bordetella pertussis infection: pathogenesis, diagnosis, management, and the role of protective immunity.
Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective randomized Acellular Pertussis Vaccine Trial (APERT).
Bordetella pertussis isolates in Finland: serotype and fimbrial expression.
Bordetella pertussis lipopolysaccharide resists the bactericidal effects of pulmonary surfactant protein A.
Bordetella pertussis modulates human macrophage defense gene expression.
Bordetella pertussis PCR: simultaneous targeting of signature sequences.
Bordetella pertussis Strain Lacking Pertactin and Pertussis Toxin.
Bordetella pertussis strains with increased toxin production associated with pertussis resurgence.
Bordetella Pertussis Toxin does not induce the release of pro-inflammatory cytokines in human whole blood.
Bordetella pertussis toxin induces the release of inflammatory cytokines and dendritic cell activation in whole blood: impaired responses in human newborns.
Bordetella pertussis vaccine strains and circulating isolates in Serbia.
Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance.
Bordetella pertussis, the Causative Agent of Whooping Cough, Evolved from a Distinct, Human-Associated Lineage of B. bronchiseptica.
Bordetella pertussis: new concepts in pathogenesis and treatment.
Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection.
Both alpha(1A)- and alpha(1B)-adrenergic receptors crosstalk to down regulate beta(1)-ARs in mouse heart: coupling to differential PTX-sensitive pathways.
Both dopamine and the putative dopamine D3 receptor antagonist PNU-99194A induce a biphasic inhibition of phorbol ester-stimulated arachidonic acid release from CHO cells transfected with the dopamine D3 receptor.
Both ET(A) and ET(B) receptors are involved in mitogen-activated protein kinase activation and DNA synthesis of astrocytes: study using ET(B) receptor-deficient rats (aganglionosis rats).
Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel.
Both GABAA and GABAB receptors participate in suppression of [CA2+]i pulsing in toad melanotrophs.
Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy.
Both overlapping and distinct signaling pathways for somatostatin receptor subtypes SSTR1 and SSTR2 in pituitary cells.
Both pertussis toxin-sensitive and insensitive g-proteins link melatonin receptor to inhibition of adenylate cyclase in the ovine pars tuberalis.
Botulinum C2 toxin ADP-ribosylates actin.
Bovine pituitary, kidney, uterine and mammary gland extracts contain bovine mammary epithelium growth factors that synergise with IGF-I and fetal calf serum: indication for involvement of GTP-binding proteins.
Bovine serum albumin-estrogen compounds differentially alter gonadotropin-releasing hormone-1 neuronal activity.
Bradycardia induced by Mesobuthus tamulus scorpion venom involves muscarinic receptor-G-protein-coupled cell signaling pathways.
Bradykinin activates airway parasympathetic ganglion neurons by inhibiting M-currents.
Bradykinin activates protein kinase C in cultured cortical collecting tubular cells.
Bradykinin B2 receptor-mediated proliferation via activation of the Ras/Raf/MEK/MAPK pathway in rat vascular smooth muscle cells.
Bradykinin B2 receptors activate Na+/H+ exchange in mIMCD-3 cells via Janus kinase 2 and Ca2+/calmodulin.
Bradykinin binding to B2 kinin receptors and stimulation of phosphoinositide turnover and arachidonic acid release in primary cultures of cells from late pregnant rat myometrium.
Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and G alpha q/11.
Bradykinin induced a positive chronotropic effect via stimulation of T- and L-type calcium currents in heart cells.
Bradykinin induces the bi-phasic production of lysophosphatidyl inositol and diacylglycerol in a dorsal root ganglion X neurotumor hybrid cell line, F-11.
Bradykinin inhibition of N- and L-type calcium channel currents in NG108-15 cells.
Bradykinin inhibits adenylate cyclase activity in guinea pig ileum membranes via a separate high-affinity bradykinin B2 receptor.
Bradykinin modulates potassium and calcium currents in neuroblastoma hybrid cells via different pertussis toxin-insensitive pathways.
Bradykinin modulates the electrophysiology of cultured rat sensory neurons through a pertussis toxin-insensitive G protein.
Bradykinin receptor localization and cell signaling pathways used by bradykinin in the regulation of gonadotropin-releasing hormone secretion.
Bradykinin receptors of cerebral microvessels stimulate phosphoinositide turnover.
Bradykinin stimulates a rise in cytosolic calcium in renal glomerular mesangial cells via a pertussis toxin insensitive pathway.
Bradykinin stimulates GTP hydrolysis in NG108-15 membranes by a high-affinity, pertussis toxin-insensitive GTPase.
Bradykinin stimulates NF-kappaB activation and interleukin 1beta gene expression in cultured human fibroblasts.
Bradykinin stimulates production of inositol (1,4,5) trisphosphate in cultured mesangial cells of the rat via a BK2-kinin receptor.
Bradykinin stimulation of inositol phosphate and calcium responses in insensitive to pertussis toxin in NG115-401L neuronal cells.
Bradykinin stimulation of inositol polyphosphate production in porcine aortic endothelial cells.
Bradykinin-activated membrane-associated phospholipase C in Madin-Darby canine kidney cells.
Bradykinin-activated transmembrane signals are coupled via No or Ni to production of inositol 1,4,5-trisphosphate, a second messenger in NG108-15 neuroblastoma-glioma hybrid cells.
Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro.
Bradykinin-induced chloride conductance in murine proximal tubule epithelial cells.
Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C.
Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca2+ influx via reverse-mode activity of the Na+/Ca2+ exchanger.
Bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization in canine cultured tracheal epithelial cells.
Bradykinin-stimulated p42/p44 MAPK activation associated with cell proliferation in corneal keratocytes.
Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats.
Break of unresponsiveness of delayed-type hypersensitivity to sheep red blood cells by pertussis toxin.
Breast cancer cell response to calcitonin: modulation by growth-regulating agents.
Bromocriptine stimulates Na+, K(+)-ATPase in renal proximal tubules via the cAMP pathway.
Bromocriptine transcriptionally activates the multidrug resistance gene (pgp2/mdr1b) by a novel pathway.
Bromocriptine, a dopamine D2 receptor agonist, inhibits adenylyl cyclase activity in rat olfactory epithelium.
Bu Shen Yi Sui Capsule Alleviates Neuroinflammation and Demyelination by Promoting Microglia toward M2 Polarization, Which Correlates with Changes in miR-124 and miR-155 in Experimental Autoimmune Encephalomyelitis.
Buprenorphine prevents and reverses the expression of chronic etorphine-induced sensitization of adenylyl cyclase in SK-N-SH human neuroblastoma cells.
Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways.
Butyrate Attenuates Inflammation and Lipolysis Generated by the Interaction of Adipocytes and Macrophages.
Butyrate enhancement of inteleukin-1? production via activation of oxidative stress pathways in lipopolysaccharide-stimulated THP-1 cells.
C-C chemokines induce the chemotaxis of NK and IL-2-activated NK cells. Role for G proteins.
C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients.
C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro.
C-peptide increases the expression of vasopressin-activated calcium-mobilizing receptor gene through a G protein-dependent pathway.
C-peptide makes a comeback.
C-peptide reverses TGF-beta1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy.
C-peptide signals via Galpha i to protect against TNF-alpha-mediated apoptosis of opossum kidney proximal tubular cells.
C-peptide stimulates ERK1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells.
C-peptide stimulates rat renal tubular Na+, K(+)-ATPase activity in synergism with neuropeptide Y.
C-terminal deletion of metabotropic glutamate receptor 1 selectively abolishes coupling to Galphaq.
C-terminal modifications of pertussis toxin-sensitive G-protein alpha-subunits differentially affect immunoreactivity. Evidence against endogenous ADP-ribosylation in human heart, lung, thrombocytes and adipose tissue.
C-terminal parathyroid hormone-related protein (PTHrP) (107-139) stimulates intracellular Ca(2+) through a receptor different from the type 1 PTH/PTHrP receptor in osteoblastic osteosarcoma UMR 106 cells.
C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor-mediated signalling.
C-type natriuretic peptide and brain natriuretic peptide inhibit adenylyl cyclase activity: interaction with ANF-R2/ANP-C receptors.
C-type natriuretic peptide attenuates evoked dopamine efflux by influencing Goalpha.
C-type natriuretic peptide enhances amylase release through NPR-C receptors in the exocrine pancreas.
C-type natriuretic peptide neuromodulates via "clearance" receptors.
C3 toxin activates the stress signaling pathways, JNK and p38, but antagonizes the activation of AP-1 in rat-1 cells.
C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophils.
C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins.
C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation.
C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway.
C3a and C5a stimulate chemotaxis of human mast cells.
C3A binds to the seven transmembrane anaphylatoxin receptor expressed by epithelial cells and triggers the production of IL-8.
C3a enhances nerve growth factor-induced NFAT activation and chemokine production in a human mast cell line, HMC-1.
C3a receptor on dibutyryl-cAMP-differentiated U937 cells and human neutrophils: the human C3a receptor characterized by functional responses and 125I-C3a binding.
C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase.
C5a differentially stimulates the ERK1/2 and p38 MAPK phosphorylation through independent signaling pathways to induced chemotactic migration in RAW264.7 macrophages.
C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils.
C5a stimulus-secretion coupling in rat basophilic leukaemia (RBL-2H3) cells transfected with the human C5a receptor is mediated by pertussis and cholera toxin-sensitive G proteins.
C?type natriuretic peptide prevents angiotensin II?induced atrial connexin 40 and 43 dysregulation by activating AMP?activated kinase signaling.
Ca(++)-dependent constitutive nitric oxide synthase is not involved in the cyclic GMP-increasing effects of carbachol in ventricular cardiomyocytes.
Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration.
Ca(2+)-dependent and -independent mechanism of cyclic-AMP reduction: mediation by bradykinin B2 receptors.
Ca(2+)-inactivated K+ current is modulated by endothelin-1 in B-16 murine melanoma cells.
Ca(2+)-mobilizing endothelin-A receptors inhibit voltage-gated Ca(2+) influx through G(i/o) signaling pathway in pituitary lactotrophs.
Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons.
Ca2+ channel activation by platelet-derived growth factor-induced tyrosine phosphorylation and Ras guanine triphosphate-binding proteins in rat glomerular mesangial cells.
Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells.
Ca2+ channel inhibition by kappa opioid receptors expressed in Xenopus oocytes.
Ca2+ dependent purinergic regulation of p42 and p44 MAP kinases in astroglial cultured cells.
Ca2+ influx and neurite growth in response to purified N-cadherin and laminin.
Ca2+ influx stimulated by vasopressin is mediated by phosphoinositide hydrolysis in rat smooth muscle cells.
Ca2+ influx, phosphoinositide hydrolysis, and histamine release induced by lysophosphatidylserine in mast cells.
Ca2+ inhibition of beta-adrenergic receptor- and forskolin-stimulated cAMP accumulation in C6-2B rat glioma cells is independent of protein kinase C.
Ca2+ ionophore A23187 and thrombin inhibit the pertussis-toxin-induced ADP-ribosylation of the alpha-subunit of the inhibitory guanine-nucleotide-binding protein and other proteins in human platelets.
Ca2+ mobilization by the LH receptor expressed in Xenopus oocytes independent of 3',5'-cyclic adenosine monophosphate formation: evidence for parallel activation of two signaling pathways.
Ca2+ participates in alpha1B-adrenoceptor-mediated cAMP response in HEK293 cells.
Ca2+ preconditioning elicits a unique protection against the Ca2+ paradox injury in rat heart. Role of adenosine. Fixed.
Ca2+ release from inositol 1,4,5-trisphosphate-sensitive Ca2+ store by antidepressant drugs in cultured neurons of rat frontal cortex.
Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.
Ca2+-channel-dependent and -independent inhibition of exocytosis by extracellular ATP in voltage-clamped rat adrenal chromaffin cells.
Ca2+-independent feedback inhibition of acetylcholine release in frog neuromuscular junction.
Ca2+-independent synergistic augmentation of O2- production by FMLP and PMA in HL-60 cells.
Ca2+-sensing receptors in intestinal epithelium.
Ca2+-stimulated catecholamine release from alpha-toxin-permeabilized PC12 cells: biochemical evidence for exocytosis and its modulation by protein kinase C and G proteins.
Cadmium inhibits GABA-activated ion currents by increasing intracellular calcium level in snail neurons.
Caffeine to prevent respiratory failure and improve outcome in infant pertussis.
Calcitonin gene-related peptide (CGRP) activates human neutrophils--inhibition by chemotactic peptide antagonist BOC-MLP.
Calcitonin gene-related peptide activates different signaling pathways in mesenteric lymphatics of guinea pigs.
Calcitonin gene-related peptide receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+ signaling pathways.
Calcitonin gene-related peptide: mechanisms of modulation of antral endocrine cells and cholinergic neurons.
Calcitonin induces IL-6 production via both PKA and PKC pathways in the pituitary folliculo-stellate cell line.
Calcitonin inhibits accumulation of cyclic AMP in stimulated peritoneal macrophages from normal rats but not from osteopetrotic (incisors-absent) littermates.
Calcitonin reverts pertussis toxin blockade of the opioid analgesia in mice.
Calcitonin-gene-related peptide activates the muscarinic-gated K+ current in atrial cells.
Calcitriol attenuates the thyrotropin-releasing hormone-stimulated inositol phosphate production in clonal rat pituitary (GH4C1) cells.
Calcium changes in immune complex-stimulated human neutrophils. Simultaneous measurement of receptor occupancy and activation reveals full population stimulus binding but subpopulation activation.
Calcium channel currents and their inhibition by (-)-baclofen in rat sensory neurones: modulation by guanine nucleotides.
Calcium current modulation in frog sympathetic neurones: multiple neurotransmitters and G proteins.
Calcium entry stimulated by swelling of Madin-Darby canine kidney cells.
Calcium flux-independent NMDA receptor activity is required for A? oligomer-induced synaptic loss.
Calcium handling and purinoceptor subtypes involved in ATP-induced contraction in rat small mesenteric arteries.
Calcium inflow in cells transfected with cloned rat and porcine calcitonin receptors.
Calcium influx into mouse spermatozoa activated by solubilized mouse zona pellucida, monitored with the calcium fluorescent indicator, fluo-3. Inhibition of the influx by three inhibitors of the zona pellucida induced acrosome reaction: tyrphostin A48, pertussis toxin, and 3-quinuclidinyl benzilate.
Calcium influx into neurons can solely account for cell contact-dependent neurite outgrowth stimulated by transfected L1.
Calcium influx mediated by the Escherichia coli heat-stable enterotoxin B (STB).
Calcium inhibition of cardiac adenylyl cyclase. Evidence for two distinct sites of inhibition.
Calcium mobilization and cell proliferation activated by extracellular ATP in human ovarian tumour cells.
Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons.
Calcium mobilization and signal transduction in the neutrophils.
Calcium mobilization in fluoride activated human neutrophils.
Calcium mobilization, prostaglandin E2 and alpha 2-adrenoceptor modulation of glucose utilization and insulin secretion in pancreatic islets.
Calcium release from intracellular stores evoked by extracellular ATP in a Xenopus renal epithelial cell line.
Calcium signaling capacity of the CD11b/CD18 integrin on human neutrophils.
Calcium signaling induced by angiotensin II in the pancreatic acinar cell line AR42J.
Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells.
Calcium signals activated by arachidonic acid in embryonic chick ciliary ganglion neurons.
Calcium waves in fluid flow stimulated osteoblasts are G protein mediated.
Calcium- and G-protein-dependent activation of arachidonic acid release by concanavalin-A-stimulated mouse macrophages.
Calcium-and G-protein-related spasmolytic effects of nonsteroidal anti-inflammatory drugs on rat uterus contractions in vitro.
Calcium-controlled secretion is effected through a guanine nucleotide regulatory protein in parathyroid cells.
Calcium-dependent release of arachidonic acid in response to purinergic receptor activation in airway epithelium.
Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses.
Calcium-sensing receptor modulates extracellular Ca2+ entry via TRPC-encoded receptor-operated channels in human aortic smooth muscle cells.
Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts.
Calcium-sensing receptor-mediated ERK1/2 activation requires Galphai2 coupling and dynamin-independent receptor internalization.
Calibration of pertussis toxin BRP batch 1 in a standardised CHO cell-based clustering assay.
Calpain inhibition induces activation of the distinct signalling pathways and cell migration in human monocytes.
Calpain inhibitors stimulate phagocyte functions via activation of human formyl peptide receptors.
Calpain regulates neutrophil chemotaxis.
Calpain-mediated regulation of the distinct signaling pathways and cell migration in human neutrophils.
cAMP analogues downregulate the expression of granulocyte macrophage colony-stimulating factor (GM-CSF) in human bone marrow stromal cells in vitro.
cAMP antagonizes ERK-dependent antiapoptotic action of insulin.
cAMP cascade (PKA, Epac, adenylyl cyclase, Gi, and phosphodiesterases) regulates myelin phagocytosis mediated by complement receptor-3 and scavenger receptor-AI/II in microglia and macrophages.
cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin.
cAMP modulates transepithelial resistance response of LLC-PK1 renal epithelia to tumor necrosis factor.
cAMP production by piglet cerebral vascular smooth muscle cells: pH(o), pH(i), and permissive action of PGI(2).
cAMP signaling mechanisms with aging in rats.
cAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification.
cAMP-dependent inhibition is dominant in regulating superoxide production in the bone-resorbing osteoclasts.
cAMP-independent dilation of coronary arterioles to adenosine : role of nitric oxide, G proteins, and K(ATP) channels.
Can immunization affect the development of allergy?
Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor.
Cannabichromene is a cannabinoid CB2 receptor agonist.
Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism.
Cannabidiol, a novel inverse agonist for GPR12.
Cannabinoid agonists induce contractile responses through Gi/o-dependent activation of phospholipase C in the bovine ciliary muscle.
Cannabinoid agonists stimulate [3H]GABA release in the globus pallidus of the rat when G(i) protein-receptor coupling is restricted: role of dopamine D2 receptors.
Cannabinoid CB1 receptor elevation of intracellular calcium in neuroblastoma SH-SY5Y cells: interactions with muscarinic and delta-opioid receptors.
Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current.
Cannabinoid CB1 receptor-mediated inhibition of glutamate release from rat hippocampal synaptosomes.
Cannabinoid CB1 receptor-mediated inhibition of prolactin release and signaling mechanisms in GH4C1 cells.
Cannabinoid CB1 receptors fail to cause relaxation, but couple via Gi/Go to the inhibition of adenylyl cyclase in carotid artery smooth muscle.
Cannabinoid ligand-receptor signaling in the mouse uterus.
Cannabinoid receptor 1 but not 2 mediates macrophage phagocytosis by G(?)i/o /RhoA/ROCK signaling pathway.
Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury.
Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines.
Cannabinoid Receptor Activation Correlates with the Proapoptotic Action of the ?2-Adrenergic Agonist (R,R')-4-Methoxy-1-Naphthylfenoterol in HepG2 Hepatocarcinoma Cells.
Cannabinoid receptor agonists inhibit depolarization-induced calcium influx in cerebellar granule neurons.
Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures.
Cannabinoid receptor CB1 activates the Na+/H+ exchanger NHE-1 isoform via Gi-mediated mitogen activated protein kinase signaling transduction pathways.
Cannabinoid receptor subtype influence on neuritogenesis in human SH-SY5Y cells.
Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil.
Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII.
Cannabinoid receptor-mediated translocation of NO-sensitive guanylyl cyclase and production of cyclic GMP in neuronal cells.
Cannabinoid receptors and modulation of cyclic AMP accumulation in the rat brain.
Cannabinoid receptors and the cytokine network.
Cannabinoid receptors differentially modulate potassium A and D currents in hippocampal neurons in culture.
Cannabinoid-induced depression of synaptic transmission is switched to stimulation when dopaminergic tone is increased in the globus pallidus of the rodent.
Cannabinoid-receptor-independent cell signalling by N-acylethanolamines.
Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide.
Cannabinoids enhance human B-cell growth at low nanomolar concentrations.
Cannabinoids enhance NMDA-elicited Ca2+ signals in cerebellar granule neurons in culture.
Cannabinoids inhibit agonist-stimulated formation of inositol phosphates in rat hippocampal cultures.
Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.
Cannabinoids modulate potassium current in cultured hippocampal neurons.
Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling.
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides.
Cap formation in a B-lymphocyte cell line is inhibited by pertussis toxin and phorbol ester.
Caprine sperm acrosome reaction: promotion by progesterone and homologous zona pellucida.
Capsaicin-induced ion fluxes increase cyclic GMP but not cyclic AMP levels in rat sensory neurones in culture.
Captopril inhibits the hydroosmotic effect of ADH in the cortical collecting tubule.
CaR activation increases TNF production by mTAL cells via a Gi-dependent mechanism.
Carbachol activates a novel sodium current in isolated guinea pig ventricular myocytes via M2 muscarinic receptors.
Carbachol and bradykinin increase the production of diacylglycerol from sources other than inositol-containing phospholipids in PC12 cells.
Carbachol depolarizes and accelerates pacemaker activity in the sinoatrial node of chicks treated with pertussis toxin.
Carbachol enhances forskolin-stimulated cyclic AMP accumulation via activation of calmodulin system in human neuroblastoma SH-SY5Y cells.
Carbachol inhibition of Ca2+ currents in ventricular cells obtained from neonatal and adult rats.
Carbachol inhibits stimulant-induced increases in fundic D-cell cytosolic Ca2+ concentration.
Carbachol mimics phorbol esters in its ability to enhance cyclic GMP production by STa, the heat-stable toxin of Escherichia coli.
Carbachol-induced actin reorganization involves Gi activation of Rho in human airway smooth muscle cells.
Carbachol-induced decrease in thyroid cell adenylyl cyclase activity is independent of calcium and phosphodiesterase activation.
Carbachol-induced secretion and homologous desensitization in rat basophilic leukemia (RBL-2H3) cells transfected with human m2 muscarinic acetylcholine receptors.
Carbachol-stimulated calcium entry in SH-SY5Y human neuroblastoma cells: which route?
Carbamylcholine inhibits beta-adrenergic receptor-coupled Gs protein function proximal to adenylate cyclase.
Carbohydrate moiety of follitropin receptor is not required for high affinity hormone-binding or for functional coupling between receptor and guanine nucleotide-binding protein in bovine calf testis membranes.
Carboxyl domain of glutamate receptor directs its coupling to metabolic pathways.
Cardiac alpha 1-adrenoceptors stimulate a high-affinity GTPase activity in sarcolemmal membranes from rabbit atrial and ventricular myocytes.
Cardiac effects of long-term active immunization with the second extracellular loop of human ?1- and/or ?3-adrenoceptors in Lewis rats.
Cardiac role of frog ANF: negative inotropism and binding sites in Rana esculenta.
Cardiac swelling-induced chloride current is enhanced by endothelin.
Cardiac-specific overexpression of human beta2 adrenoceptors in mice exposes coupling to both Gs and Gi proteins.
Cardiomyocyte S1P1 Receptor-mediated Extracellular Signal-related Kinase Signaling and Desensitization.
Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways.
Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptors.
Cardioprotective effects of acute and chronic opioid treatment are mediated via different signaling pathways.
Cardiovascular responses to milrinone in pertussis toxin-pretreated pithed rats.
CART peptide stimulation of G protein-mediated signaling in differentiated PC12 Cells: Identification of PACAP 6-38 as a CART receptor antagonist.
Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling.
Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation.
Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human immunodeficiency virus type 1 envelope glycoprotein (gp120).
Catecholamine modulation of calcium currents in clonal pancreatic beta-cells.
Catecholamine stimulated lipolysis in differentiated human preadipocytes in a serum-free, defined medium.
Catecholamines are not linked to myometrial phospholipase C and uterine contraction in late pregnant and parturient mouse.
Catecholamines stimulate the proliferation and alkaline phosphatase activity of MC3T3-E1 osteoblast-like cells.
Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides.
Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines.
Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection.
Cathine and norephedrine, both phenylpropanolamines, accelerate capacitation and then inhibit spontaneous acrosome loss.
Cationic-amphiphilic arpromidine-derived guanidines and a histamine trifluoromethyl-toluidide derivative may activate pertussis toxin-sensitive G-proteins by a receptor-independent mechanism.
Caveolae modulate excitation-contraction coupling and beta(2)-adrenergic signalling in adult rat ventricular myocytes.
Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes.
CB1 allosteric modulator Org27569 is an antagonist/inverse agonist of ERK1/2 signaling.
CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes.
CB1 cannabinoid receptor-mediated cell migration.
CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function.
CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains.
CB1 receptor-independent actions of SR141716 on G-protein signaling: coapplication with the mu-opioid agonist Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol unmasks novel, pertussis toxin-insensitive opioid signaling in mu-opioid receptor-Chinese hamster ovary cells.
CB2 cannabinoid receptor targets mitogenic Gi protein - cyclin D1 axis in osteoblasts.
CC chemokine ligand 20 partially controls adhesion of naive B cells to activated endothelial cells under shear stress.
CC chemokine receptor-3 undergoes prolonged ligand-induced internalization.
CC family chemokines directly regulate myoblast responses to skeletal muscle injury.
CCK and gastrin inhibit adenylate cyclase activity through a pertussis toxin-sensitive mechanism in the tumoral rat pancreatic acinar cell line AR 4-2J.
CCK-8-evoked cationic currents in substantia nigra dopaminergic neurons are mediated by InsP3-induced Ca2+ release.
CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons.
CCR1 acts downstream of NFAT2 in osteoclastogenesis and enhances cell migration.
CCR2 expression by brain microvascular endothelial cells is critical for macrophage transendothelial migration in response to CCL2.
CCR5 internalisation and signalling have different dependence on membrane lipid raft integrity.
CCR5 knockout suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice.
CCR6 ligands inhibit HIV by inducing APOBEC3G.
CCR7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells.
CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner.
CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I.
CD3/T-cell receptor coupling to a pertussis and cholera toxin-insensitive G-protein.
CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A.
CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration.
CD69 in resting and activated T lymphocytes. Its association with a GTP binding protein and biochemical requirements for its expression.
CD69-induced monocyte apoptosis involves multiple nonredundant signaling pathways.
CD8 T-cell Recruitment Into the Central Nervous System of Cuprizone-Fed Mice: Relevance to Modeling the Etiology of Multiple Sclerosis.
CD8+ T cell suppressor factors and the control of infection, replication and transcription of human immunodeficiency virus.
Celecoxib simulates respiratory burst through pertussis toxin-sensitive G-protein, a possible signal for beta 2-integrin expression on human neutrophils.
Cell cycle analysis of Chinese hamster ovary cells stimulated by phosphatidic acid in serum-free culture.
Cell cycle-dependent coupling of the calcitonin receptor to different G proteins.
Cell cycle-dependent coupling of the vasopressin V1a receptor to different G proteins.
Cell signaling and estrogens in female rat osteoblasts: a possible involvement of unconventional nonnuclear receptors.
Cell signalling pathway involved in PACAP-induced AR4-2J cell proliferation.
Cell surface antigens of Bordetella pertussis.
Cell surface beta-1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling.
Cell surface CCR5 density determines the postentry efficiency of R5 HIV-1 infection.
Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells.
Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts.
Cell type-specific differences in the coupling of recombinant mGlu1alpha receptors to endogenous G protein sub-populations.
Cell-based assay of nongenomic actions of progestins revealed inhibitory G protein coupling to membrane progestin receptor ? (mPR?).
Cell-density-dependent expression of the alpha(2)-adrenergic response by epidermal growth factor (EGF) in primary cultures of adult rat hepatocytes.
Cell-density-dependent expression of the beta-adrenergic response by epidermal growth factor (EGF) in primary cultures of adult rat hepatocytes.
Cell-mediated and antibody responses to Bordetella pertussis antigens in children vaccinated with acellular or whole-cell pertussis vaccines. The Progetto Pertosse-CMI Working Group.
Cell-mediated immune responses to antigens of Bordetella pertussis and protection against pertussis in school children.
Cell-mediated immunity and antibody responses to Bordetella pertussis antigens in children with a history of pertussis infection and in recipients of an acellular pertussis vaccine.
Cell-signaling evidence for adenosine stimulation of coronary smooth muscle proliferation via the A1 adenosine receptor.
Cell-specific coupling of PGE2 to different transduction pathways in arginine vasopressin- and glucagon-sensitive segments of the rat renal tubule.
Cell-specific coupling of the cloned human 5-HT1F receptor to multiple signal transduction pathways.
Cell-specific expression of guanine nucleotide-binding proteins in rat testicular cells.
Cell-specific signaling of the 5-HT1A receptor. Modulation by protein kinases C and A.
Cell-surface bound pertussis toxin induces polyclonal T cell responses with high levels of interferon-gamma in the absence of interleukin-12.
Cell-surface expression, progestin binding, and rapid nongenomic signaling of zebrafish membrane progestin receptors alpha and beta in transfected cells.
Cellular Basis for Bimatoprost Effects on Human Conventional Outflow.
Cellular cyclic AMP levels modulate insulin sensitivity and responsiveness--evidence against a significant role of Gi in insulin signal transduction.
Cellular distribution and biochemical characterization of G proteins in skeletal muscle: comparative location with voltage-dependent calcium channels.
Cellular distribution of G protein Go alpha in pituitary lactotrophs: effects of dopamine.
Cellular expression of functional chemokine receptor CCR5 and CXCR4 in human embryonic neurons.
Cellular immunity in adolescents and adults following acellular pertussis vaccine administration.
Cellular internalization of proinsulin C-peptide.
Cellular mechanism of acetylcholine-induced response in dissociated outer hair cells of guinea-pig cochlea.
Cellular mechanism of action of cognitive enhancers: effects of nefiracetam on neuronal Ca2+ channels.
Cellular mechanism of lithium-induced nephrogenic diabetes insipidus in rats.
Cellular mechanisms by which oxytocin mediates ovine endometrial prostaglandin F2alpha synthesis: role of G(i) proteins and mitogen-activated protein kinases.
Cellular mechanisms of adrenaline-induced hyperpolarization in renal epitheloid MDCK cells.
Cellular mechanisms of ATP-induced hyperpolarization in renal epitheloid MDCK-cells.
Cellular mechanisms of bradykinin-induced hyperpolarization in renal epitheloid MDCK-cells.
Cellular mechanisms of melatonin action.
Cellular mechanisms of somatostatin inhibition of calcium influx in the anterior pituitary cell line AtT-20.
Cellular mechanisms underlying adenosine actions on cholinergic transmission in enteric neurons.
Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus.
Cellular mechanisms underlying cognition-enhancing actions of nefiracetam (DM-9384).
Cellular pertussis vaccine containing a Bordetella pertussis strain that produces a nontoxic pertussis toxin molecule.
Cellular responses to stimulation of the M5 muscarinic acetylcholine receptor as seen in murine L cells.
Cellular signalling by lipoproteins in cultured smooth muscle cells from spontaneously hypertensive rats.
Cellular signalling of PGE2 and its selective receptor analogue sulprostone in rabbit cortical collecting duct.
Cementum specific components which influence periodontal connective tissue cells.
Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis.
Central effects of quinpirole on blood pressure of spontaneously hypertensive rats.
Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats.
Central pertussis toxin abolishes the intestinal inhibition induced by intracerebroventricular morphine.
Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model.
Ceramide 1-(2-cyanoethyl) phosphate enhances store-operated Ca2+ entry in thyroid FRTL-5 cells.
Ceramide 1-phosphate enhances calcium entry through voltage-operated calcium channels by a protein kinase C-dependent mechanism in GH4C1 rat pituitary cells.
Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate.
Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration.
Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells.
Ceramide 1-phosphate stimulates glucose uptake in macrophages.
Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
Cerebellar CB(1) receptor mediation of Delta(9)-THC-induced motor incoordination and its potentiation by ethanol and modulation by the cerebellar adenosinergic A(1) receptor in the mouse.
Cerebral muscarinic acetylcholine receptors interact with three kinds of GTP-binding proteins in a reconstitution system of purified components.
CFTR is activated through stimulation of purinergic P2Y(2) receptors.
Change of intracellular calcium of neural cells induced by extracellular ATP.
Changes in binding of iodomelatonin to membranes of Leydig cells and steroidogenesis after prolonged in vitro exposure to melatonin.
Changes in cAMP formation in mononuclear leukocytes of heart and renal transplant recipients.
Changes in expression of a functional Gi protein in cultured rat heart cells.
Changes in G protein pattern and in G protein-dependent signaling during erythropoietin- and dimethylsulfoxide-induced differentiation of murine erythroleukemia cells.
Changes in genetic diversity of the Bordetella pertussis population in the United Kingdom between 1920 and 2006 reflect vaccination coverage and emergence of a single dominant clonal type.
Changes in inositol 1,4,5-trisphosphate mass in agonist-stimulated human neutrophils.
Changes in intracellular Ca2+ by activation of P2 receptors in submucosal neurons in short-term cultures.
Changes in intracellular free calcium in isolated myometrial cells: role of extracellular and intracellular calcium and possible involvement of guanine nucleotide-sensitive proteins.
Changes in the acoustic startle response and prepulse inhibition of acoustic startle in rats after local injection of pertussis toxin into the ventral tegmental area.
Changes in the Dutch Bordetella pertussis population in the first 20 years after the introduction of whole-cell vaccines.
Changes in the guanine nucleotide-binding proteins, Gi and Go, during differentiation of 3T3-L1 cells.
Changes in vascular smooth muscle function in hypertension.
Changes of ADP-ribosylation of GTP-binding protein by pertussis toxin in human platelets during long-term treatment of manic depression with lithium carbonate.
Changes of cytosolic calcium ion concentrations in human endothelial cells in response to thrombin, platelet-activating factor, and leukotriene B4.
Changes of the Swedish Bordetella pertussis population in incidence peaks during an acellular pertussis vaccine period between 1997 and 2004.
Characterisation of human recombinant somatostatin receptors. 4. Modulation of phospholipase C activity.
Characterisation of the fish sst3 receptor, a member of the SRIF1 receptor family: atypical pharmacological features.
Characteristics and distribution of endogenous RFamide-related peptide-1.
Characteristics and potency of an acellular pertussis vaccine composed of pertussis toxin, filamentous hemagglutinin, and pertactin.
Characteristics of acid extrusion from Chinese hamster ovary cells expressing different prostaglandin EP receptors.
Characteristics of lysophosphatidylcholine-induced Ca2+ response in human neuroblastoma SH-SY5Y cells.
Characteristics of nitric oxide-mediated cholinergic modulation of calcium current in rabbit sino-atrial node.
Characterization and clinical study on the acellular pertussis vaccine produced by a combination of column purified pertussis toxin and filamentous hemagglutinin.
Characterization and detoxification of an easily prepared acellular pertussis vaccine. Antigenic role of the A protomer of pertussis toxin.
Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa.
Characterization and functional expression of a somatostatin receptor coupled to adenylyl cyclase.
Characterization and possible mechanisms of alpha 2-adrenergic receptor-mediated sensitization of forskolin-stimulated cyclic AMP production in HT29 cells.
Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells.
Characterization and subcellular distribution of G-proteins in highly purified skeletal muscle fractions from rabbit and frog.
Characterization of a Ca2+ response to both UTP and ATP at human P2Y11 receptors: evidence for agonist-specific signaling.
Characterization of a complement-fragment-C5a-stimulated calcium-influx mechanism in U937 monocytic cells.
Characterization of a cyclosporin A-sensitive activation pathway in cultured T and natural killer cells.
Characterization of a G protein-activated phosphoinositide 3-kinase in vascular smooth muscle cell nuclei.
Characterization of a G-protein from the mandibular organ of the lobster Homarus americanus (Nephropidae, Decapoda).
Characterization of a Gi-protein from Trypanosoma cruzi epimastigote membranes.
Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium.
Characterization of a key neutralizing epitope on pertussis toxin recognized by monoclonal antibody 1B7.
Characterization of a mastoparan-stimulated nucleotidase from bovine brain.
Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein.
Characterization of a neuronal cell line expressing native human melanin-concentrating hormone receptor 1 (MCHR1).
Characterization of a novel chemotactic factor for neutrophils in the bronchial secretions of patients with cystic fibrosis.
Characterization of a novel sphingosine 1-phosphate receptor, Edg-8.
Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid.
Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct.
Characterization of a Rat Model of Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Associated Crescentic Glomerulonephritis.
Characterization of a receptor for insect tachykinin-like peptide agonists by functional expression in a stable Drosophila Schneider 2 cell line.
Characterization of a stimulatory adenosine A2a receptor in adult rat ventricular myocyte.
Characterization of a streptococcal antitumor glycoprotein (SAGP).
Characterization of a unique ADP-ribosyltransferase of Mycoplasma penetrans.
Characterization of a zebrafish (Danio rerio) sphingosine 1-phosphate receptor expressed in the embryonic brain.
Characterization of adenosine A1 receptors in intact DDT1 MF-2 smooth muscle cells.
Characterization of adenosine receptors in brush-border membranes from pig kidney.
Characterization of alpha 2-adrenoceptors in a plasma membrane enriched fraction from the insulin-secreting cell line RINm5F.
Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: presence of the alpha 2-macroglobulin signaling receptor.
Characterization of an activation factor released from human neutrophils after stimulation by triclinic monosodium urate crystals.
Characterization of an atypical muscarinic cholinoceptor mediating contraction of the guinea-pig isolated uterus.
Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins.
Characterization of anandamide- and fluoroanandamide-induced antinociception and cross-tolerance to delta 9-THC after intrathecal administration to mice: blockade of delta 9-THC-induced antinociception.
Characterization of beta-adrenoceptor mediated smooth muscle relaxation and the detection of mRNA for beta1-, beta2- and beta3-adrenoceptors in rat ileum.
Characterization of Bordetella bronchiseptica strains using phenotypic and genotypic markers.
Characterization of botulinum C3-catalyzed ADP-ribosylation of rho proteins and identification of mammalian C3-like ADP-ribosyltransferase.
Characterization of bradykinin receptors in canine cultured corneal epithelial cells: pharmacological and functional studies.
Characterization of bradykinin-induced phosphoinositide turnover in neurohybrid NCB-20 cells.
Characterization of cloned somatostatin receptors SSTR4 and SSTR5.
Characterization of co-purified acellular pertussis vaccines.
Characterization of cytosolic pertussis toxin-sensitive GTP-binding protein in mastocytoma P-815 cells.
Characterization of dopamine receptors mediating inhibition of excitatory synaptic transmission in the rat hippocampal slice.
Characterization of effects of endothelin-1 on the L-type Ca2+ current in human atrial myocytes.
Characterization of endocrine gland-derived vascular endothelial growth factor signaling in adrenal cortex capillary endothelial cells.
Characterization of ep prostanoid receptor subtypes in primary cultures of bovine ciliary epithelial cells by immunofluorescent microscopy and functional studies.
Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes.
Characterization of fMet-Leu-Phe-stimulated phospholipase C in streptolysin-O-permeabilised cells.
Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line.
Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines.
Characterization of G-protein signaling in ventricular myocytes from the adult mouse heart: differences from the rat.
Characterization of G-proteins in rat glomeruli.
Characterization of galanin receptor in canine small intestinal circular muscle synaptosomes.
Characterization of galanin receptors in the insulin-secreting cell line Rin m 5F: evidence for coupling with a pertussis toxin-sensitive guanosine triphosphate regulatory protein.
Characterization of genetically inactivated pertussis toxin mutants: candidates for a new vaccine against whooping cough.
Characterization of ghrelin receptor activity in a rat pituitary cell line RC-4B/C.
Characterization of heterotrimeric G-proteins in adult Acanthocheilonema viteae.
Characterization of histamine-induced catecholamine secretion from bovine adrenal medullary chromaffin cells.
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.
Characterization of human chorionic gonadotropin as a novel angiogenic factor.
Characterization of human melanoma cell lines according to their migratory properties in vitro.
Characterization of human neutrophil and endothelial cell ligand-operated extracellular acidification rate by microphysiometry: impact of reoxygenation.
Characterization of human phagocytic cell receptors for C5A and platelet activating factor expressed in Xenopus oocytes.
Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using extracellular acidification rate changes.
Characterization of human recombinant somatostatin sst5 receptors mediating activation of phosphoinositide metabolism.
Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis.
Characterization of increased K+ permeability associated with the stimulation of receptors for immunoglobulin E on rat basophilic leukemia cells.
Characterization of individual human antibodies binding pertussis toxin stimulated by acellular immunization.
Characterization of influenza A virus activation of the human neutrophil.
Characterization of inhibition by haloperidol and chlorpromazine of a voltage-activated K+ current in rat phaeochromocytoma cells.
Characterization of ion currents elicited by a stream of fluid during spontaneous and ligand-induced chloride current oscillation in Xenopus laevis oocytes.
Characterization of lithium-induced enzyme release from human polymorphonuclear leukocytes.
Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes.
Characterization of mastoparan-induced histamine release from RBL-2H3 cells.
Characterization of melatonin binding sites in the brain and retina of the frog Rana perezi.
Characterization of melatonin receptors and signal transduction system in rat arteries forming the circle of Willis.
Characterization of membrane melatonin receptor in mouse peritoneal macrophages: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein.
Characterization of metabotropic glutamate receptors coupled to a pertussis toxin sensitive G-protein in bovine brain coated vesicles.
Characterization of monoclonal antibodies directed against domains of pertussis toxin involved in receptor recognition.
Characterization of murine lung inflammation after infection with parental Bordetella pertussis and mutants deficient in adhesins or toxins.
Characterization of murine monoclonal antibodies that recognize defined epitopes of pertussis toxin and neutralize its toxic effect on Chinese hamster ovary cells.
Characterization of muscarinic receptor-mediated cationic currents in longitudinal smooth muscle cells of mouse small intestine.
Characterization of mutant strains producing pertussis toxin cross reacting materials.
Characterization of Na+-permeable cation channels in LLC-PK1 renal epithelial cells.
Characterization of neuropeptide Y-mediated corticotropin-releasing factor synthesis and release from human placental trophoblasts.
Characterization of nitric oxide-stimulated ADP-ribosylation of various proteins from the mouse macrophage cell line ANA-1 using sodium nitroprusside and the novel nitric oxide-donating compound diethylamine dinitric oxide.
Characterization of noradrenaline-stimulated cyclic GMP formation in brain astrocytes in culture.
Characterization of P2Y receptor subtypes functionally expressed on neonatal rat cardiac myofibroblasts.
Characterization of PACAP receptors and signaling pathways in rabbit gastric muscle cells.
Characterization of PD 121981- and CGP 42112-induced unmasking of low concentration effects of angiotensin II in rabbit abdominal aorta.
Characterization of pertussis toxin analogs containing mutations in B-oligomer subunits.
Characterization of pertussis toxin by LC-MS/MS.
Characterization of pertussis toxoid by two-dimensional liquid chromatography-tandem mass spectrometry.
Characterization of pertussis-like toxin from Salmonella spp. that catalyzes ADP-ribosylation of G proteins.
Characterization of PGE(2) receptors (EP) and their role as mediators of 1alpha,25-(OH)(2)D(3) effects on growth zone chondrocytes.
Characterization of PHA and anti-T3 induced transduction mechanisms in a human T-cell leukaemia line.
Characterization of phagocyte P2 nucleotide receptors expressed in Xenopus oocytes.
Characterization of phosphatidylinositol-specific phospholipase C (PI-PLC) from Lilium daviddi pollen.
Characterization of Phospholipase A(2) Activation by Plasmin in Cultured Bovine Endothelial Cells.
Characterization of phospholipase C activity of the plasma membrane and cytosol of an osteoblast-like cell line.
Characterization of prostaglandin E2-induced Ca2+ mobilization in single bovine adrenal chromaffin cells by digital image microscopy.
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases.
Characterization of reference materials for human antiserum to pertussis antigens by an international collaborative study.
Characterization of relaxin-stimulated cyclic AMP in cultured rat anterior pituitary cells: influence of dopamine, somatostatin and gender.
Characterization of serological responses to pertussis.
Characterization of signaling pathways of P2Y and P2U purinoceptors in bovine pulmonary artery endothelial cells.
Characterization of somatostatin receptor subtypes.
Characterization of somatostatin receptors on human neuroblastoma tumors.
Characterization of specific subcellular 15-hydroxyeicosatetraenoic acid (15-HETE) binding sites on rat basophilic leukemia cells.
Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes.
Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties.
Characterization of the adenosine receptor in cultured embryonic chick atrial myocytes: coupling to modulation of contractility and adenylate cyclase activity and identification by direct radioligand binding.
Characterization of the alpha 1B-adrenergic receptors of chicken hepatocytes. Signal transduction and actions.
Characterization of the alpha1-adrenergic chronotropic response in neuropeptide Y-treated cardiomyocytes.
Characterization of the biologic activities of a recombinant human zona pellucida protein 3 expressed in human ovarian teratocarcinoma (PA-1) cells.
Characterization of the biological activities of uridine diphosphate in human dendritic cells: Influence on chemotaxis and CXCL8 release.
Characterization of the Ca2+ responses evoked by ATP and other nucleotides in mammalian brain astrocytes.
Characterization of the carbohydrate binding and ADP-ribosyltransferase activities of chemically detoxified pertussis toxins.
Characterization of the cloned human mu opioid receptor.
Characterization of the contractile P2Y14 receptor in mouse coronary and cerebral arteries.
Characterization of the endothelin-1-induced regulation of L-type Ca2+ current in rabbit ventricular myocytes.
Characterization of the G protein coupling of a somatostatin receptor to the K+ATP channel in insulin-secreting mammalian HIT and RIN cell lines.
Characterization of the G protein coupling of SRIF and beta-adrenergic receptors to the maxi KCa channel in insulin-secreting cells.
Characterization of the G protein involved in the muscarinic stimulation of adenylyl cyclase of rat olfactory bulb.
Characterization of the gonadotrophin-releasing hormone receptor in alpha T3-1 pituitary gonadotroph cells.
Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors.
Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein.
Characterization of the integrin and activation steps mediating human eosinophil and neutrophil adhesion to chronically inflamed airway endothelium.
Characterization of the key antigenic components of pertussis vaccine based on outer membrane vesicles.
Characterization of the m4 muscarinic receptor Ca2+ response in a subclone of PC-12 cells by single cell flow cytometry. Inhibition of the response by bradykinin.
Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors.
Characterization of the membrane-associated GTPase activity: effects of chemotactic factors and toxins.
Characterization of the metabotropic glutamate receptor in mouse cerebellar granule cells: lack of effect of 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (NBQX).
Characterization of the migration of lung and blood T cells in response CXCL12 in a three-dimensional matrix.
Characterization of the MMQ cell, a prolactin-secreting clonal cell line that is responsive to dopamine.
Characterization of the murine immune response to the murine TSH receptor ectodomain: induction of hypothyroidism and TSH receptor antibodies.
Characterization of the muscarinic receptor subtypes in the bovine corneal epithelial cells.
Characterization of the PGE2 receptor subtype in bovine chondrocytes in culture.
Characterization of the phosphoinositide-linked dopamine receptor in a mouse hippocampal-neuroblastoma hybrid cell line.
Characterization of the plasma membrane bound GTPase from rabbit neutrophils. I. Evidence for an Ni-like protein coupled to the formyl peptide, C5a, and leukotriene B4 chemotaxis receptors.
Characterization of the prostaglandin E receptor expressed on a cultured mast cell line, BNu-2cl3.
Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1.
Characterization of the signal transduction pathways mediating noradrenaline-stimulated MAPK activation and c-fos expression in oligodendrocyte progenitors.
Characterization of the signalling pathways involved in ATP and basic fibroblast growth factor-induced astrogliosis.
Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells.
Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.
Characterization of transducin from bovine retinal rod outer segments. Participation of the amino-terminal region of T alpha in subunit interaction.
Characterization of two Achromobacter xylosoxidans isolates from patients with pertussis-like symptoms.
Characterization of two adhesins of Bordetella pertussis for human ciliated respiratory-epithelial cells.
Characterization of umami receptor and coupling G protein in mouse taste cells.
Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons.
Characterization of vasopressin-mediated GSH efflux from Hep G2 cells: significance of protein kinase C.
Characterization of vir-activated TnphoA gene fusions in Bordetella pertussis.
Characterization of [125I]acidic fibroblast growth factor binding to the cloned human fibroblast growth factor receptor, FGF-flg, on NIH 3T3 cell membranes: inhibitory effects of heparin, pertussis toxin and guanine nucleotides.
Chemerin contributes to inflammation by promoting macrophage adhesion to VCAM-1 and fibronectin through clustering of VLA-4 and VLA-5.
Chemerin-induced arterial contraction is Gi- and calcium-dependent.
Chemical modification of islet-activating protein, pertussis toxin. Essential role of free amino groups in its lymphocytosis-promoting activity.
Chemoattractant properties of PR-39, a neutrophil antibacterial peptide.
Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.
Chemoattractant receptor-induced phosphorylation of L-selectin.
Chemoattractant receptor-specific differences in G protein activation rates regulate effector enzyme and functional responses.
Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage.
Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation.
Chemoattractant-induced activation of c-fos gene expression in human monocytes.
Chemoattractant-induced activation of vacuolar H+ pumps and of an H(+)-selective conductance in neutrophils.
Chemoattractant-stimulated GTPase activity is decreased on membranes from polymorphonuclear leukocytes incubated in chemoattractant.
Chemoattractant-stimulated NF-kappaB activation is dependent on the low molecular weight GTPase RhoA.
Chemoattraction of neutrophils by substance P and transforming growth factor-beta 1 is inadequately explained by current models of lipid remodeling.
Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons.
Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT.
Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization.
Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells.
Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues.
Chemokine receptor CXCR2 activates distinct pathways for chemotaxis and calcium mobilization.
Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS.
Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion.
Chemokine regulation of hematopoiesis and the involvement of pertussis toxin-sensitive G alpha i proteins.
Chemokine release from human rhinovirus-infected airway epithelial cells promotes fibroblast migration.
Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cells.
Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1.
Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor u51.
Chemokine-independent preference for T-helper-1 cells in transendothelial migration.
Chemokines as regulators of T cell differentiation.
Chemokines regulate cellular polarization and adhesion receptor redistribution during lymphocyte interaction with endothelium and extracellular matrix. Involvement of cAMP signaling pathway.
Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Chemotactic 5-oxo-eicosatetraenoic acids induce oxygen radical production, Ca2+-mobilization, and actin reorganization in human eosinophils via a pertussis toxin-sensitive G-protein.
Chemotactic activity of pertussis toxin on murine lymphocytes. Its potential role on lymphocyte accumulation in the lung.
Chemotactic agonists induce cytokine generation in eosinophils.
Chemotactic factor induced tyrosine phosphorylation of membrane associated proteins in rabbit peritoneal neutrophils.
Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases.
Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation.
Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages.
Chemotactic peptide receptor-supported ADP-ribosylation of a pertussis toxin substrate GTP-binding protein by cholera toxin in neutrophil-type HL-60 cells.
Chemotactic peptide, calcium and guanine nucleotide regulation of phospholipase C activity in membranes from DMSO-differentiated HL60 cells.
Chemotactic peptide-induced activation of Ras in human neutrophils is associated with inhibition of p120-GAP activity.
Chemotactic responses of osteoblastic MC3T3-E1 cells toward zinc chloride.
Chemotaxins C5a and fMLP induce release of calprotectin (leucocyte L1 protein) from polymorphonuclear cells in vitro.
Chemotaxis and differentiation of human adipose tissue CD34+/CD31- progenitor cells: role of stromal derived factor-1 released by adipose tissue capillary endothelial cells.
Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1.
Chemotaxis of chinese hamster ovary cells expressing the human neutrophil formyl peptide receptor: role of signal transduction molecules and alpha5beta1 integrin.
Chemotaxis of rat mast cells toward adenine nucleotides.
Chick embryo, a model to study the lethal activity of pertussis toxin, infectivity of Bordetella pertussis, and their neutralization by immune sera.
Chick RGS2L demonstrates concentration-dependent selectivity for pertussis toxin-sensitive and -insensitive pathways that inhibit L-type Ca2+ channels.
Chicken liver contains a large quantity of a G-protein-linked neurotensin receptor.
Chimeric Galpha(q) mutants harboring the last five carboxy-terminal residues of Galpha(i2) or Galpha(o) are resistant to pertussis toxin-catalyzed ADP-ribosylation.
Chinese hamster ovary (CHO) cell clustering does not correlate with in vivo histamine-sensitization when measuring residual activity of aldehyde-treated pertussis toxin (PT).
Chloride channel blockers inhibit ACTH secretion from mouse pituitary tumor cells.
Chloride channels in cultured human skeletal muscle are regulated by G proteins.
Chloride channels in myocytes from rabbit colon are regulated by a pertussis toxin-sensitive G protein.
Chloride efflux in cyclic AMP-induced configurational change of bovine pulmonary artery endothelial cells.
Cholecystokinin activates Gi1-, Gi2-, Gi3- and several Gs-proteins in rat pancreatic acinar cells.
Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway.
Cholera and pertussis exotoxins protect mice against the lethal Schwartzman reaction and antagonize the effects of lipopolysaccharide on second messenger systems.
Cholera and pertussis toxins amplify prostacyclin synthesis in aortic smooth muscle cells.
Cholera and pertussis toxins increase acidification of endocytic vesicles without altering ion conductances.
Cholera and pertussis toxins inhibit differently hypothermic and anti-opioid effects of neuropeptide FF.
Cholera and pertussis toxins modify regulation of glucose transport activity in rat adipose cells: evidence for mediation of a cAMP-independent process by G-proteins.
Cholera and pertussis toxins reveal multiple regulation of cAMP levels in the rabbit carotid body.
Cholera toxin accentuates the antagonism by acetylcholine of higenamine-induced positive chronotropy is isolated right atria of mice.
Cholera toxin ADP-ribosylates the receptor-coupled form of pertussis toxin-sensitive G-proteins.
Cholera toxin and dibutyryl cyclic adenosine 3',5'-monophosphate sensitize gonadotropin-releasing hormone-stimulated inositol phosphate production to inhibition in protein kinase-C (PKC)-depleted cells: evidence for cross-talk between a cholera toxin-sensitive G-protein and PKC.
Cholera toxin and pertussis toxin on opioid- and alpha 2-mediated supraspinal analgesia in mice.
Cholera toxin and pertussis toxin provoke differential effects on luteinizing hormone release, inositol phosphate production, and gonadotropin-releasing hormone (GnRH) receptor binding in the gonadotrope: evidence for multiple guanyl nucleotide binding proteins in GnRH action.
Cholera toxin and pertussis toxin regulate the Fc receptor-mediated phagocytic response of human neutrophils in a manner analogous to regulation by monoclonal antibody 1C2.
Cholera toxin and pertussis toxin stimulate prostaglandin E2 synthesis in a murine macrophage cell line.
Cholera toxin and pertussis toxin substrates and endogenous ADP-ribosyltransferase activity in Drosophila melanogaster.
Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism.
Cholera toxin blocks glucagon-mediated inhibition of the liver plasma membrane (Ca2+-Mg2+)-ATPase.
Cholera toxin but not pertussis toxin inhibits angiotensin II-enhanced contractions in the rat portal vein.
Cholera toxin can ADP-ribosylate Gs as well as Gi in ACTH-unresponsive human adrenocortical cancer.
Cholera toxin directly stimulates pregnenolone generation with increasing Ca2+ efflux in bovine adrenocortical mitochondria.
Cholera toxin inhibits interleukin-2-induced, but enhances pertussis toxin-induced T-cell proliferation: regulation by cyclic nucleotides.
Cholera toxin modulation of angiotensin II-stimulated inositol phosphate production in cultured vascular smooth muscle cells.
Cholera toxin treatment produces down-regulation of the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs).
Cholera-toxin and corticotropin modulation of inositol phosphate accumulation induced by vasopressin and angiotensin II in rat glomerulosa cells.
Cholesterol regulates contractility and inotropic response to ?2-adrenoceptor agonist in the mouse atria: Involvement of Gi-protein-Akt-NO-pathway.
Choline-linked phosphoglycerides. A source of phosphatidic acid and diglycerides in stimulated neutrophils.
Cholinergic inhibition of cAMP accumulation in Sertoli cells cultured from immature hamsters.
Cholinergic M2 muscarinic receptor-mediated inhibition of endogenous noradrenaline release from the isolated vascularly perfused rat stomach.
Cholinergic modulation of the Ca2+ response to bradykinin in neuroblastoma cells.
Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).
Cholinergic stimulation of phosphoinositide hydrolysis in rat anterior pituitary.
Cholinergic stimulation of phosphoinositide metabolism in isolated rat glomeruli.
Cholinergic-induced [3H] noradrenaline release in rat brain cortical slices is mediated via a pertussis toxin sensitive GTP binding protein and involves activation of protein kinase C.
Cholinoceptor activation subserving the effects of interferon gamma on the contractility of rat ileum.
Chromatographic resolution and immunologic identification of the alpha 40 and alpha 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain.
Chronic activation of ORL1 receptor induces supersensitization of adenylyl cyclase.
Chronic coronary arterial stenosis impairs alpha 1-adrenoreceptor signaling and cardiac performance in rats.
Chronic ethanol increases the cannabinoid receptor agonist anandamide and its precursor N-arachidonoylphosphatidylethanolamine in SK-N-SH cells.
Chronic ethanol promotes the neuronal differentiation of NG108-15 cells independently of toxin-sensitive G-proteins.
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
Chronic experimental autoimmune encephalomyelitis induced by the 89-101 myelin basic protein peptide in B10RIII (H-2r) mice.
Chronic exposure of NG 108-15 cells to inhibitory acting drugs reduces stimulatory prostaglandin E1 receptor number.
Chronic exposure of NG 108-15 cells to opiate agonists does not alter the amount of the guanine nucleotide-binding proteins Gi and Go.
Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells.
Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells.
Chronic mechanical hypersensitivity in experimental autoimmune encephalomyelitis is regulated by disease severity and neuroinflammation.
Chronic morphine administration and in vivo pertussis toxin treatment induce hyperalgesia and enhance 3H-nitrendipine binding.
Chronic morphine treatment increases stimulatory beta-2 adrenoceptor signaling in A431 cells stably expressing the mu opioid receptor.
Chronic morphine treatment up-regulates mu opioid receptor binding in cells lacking filamin A.
Chronic morphine-induced changes in mu-opioid receptors and G proteins of different subcellular loci in rat brain.
Chronic muscarinic cholinoceptor stimulation increases adenylyl cyclase responsiveness in rat cardiomyocytes by a decrease in the level of inhibitory G-protein alpha-subunits.
Chronic myelogenous leukemia-derived basophilic granulocytes express a functional active receptor for the anaphylatoxin C3a.
Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma.
Chronic oxytocin pretreatment inhibits adenylyl cyclase activity in cultured rat myometrial cells.
Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure.
Chronic treatment with dexmedetomidine desensitizes alpha 2-adrenergic signal transduction.
Chronic treatment with the opioid antagonist naltrexone favours the coupling of spinal cord ?-opioid receptors to G?z protein subunits.
CiC3-1a-mediated chemotaxis in the deuterostome invertebrate Ciona intestinalis (Urochordata).
Cigarette smoke extract-induced interleukin-6 expression is regulated by phospholipase D1 in human bronchial epithelial cells.
Ciproxifan, a histamine H3 receptor antagonist and inverse agonist, presynaptically inhibits glutamate release in rat hippocampus.
Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries.
CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells.
Cl- currents activated via purinergic receptors in Xenopus follicles.
CL316243 induces phosphatidylinositol 3,4,5-triphosphate production in rat adipocytes in an adenosine deaminase-, pertussis toxin-, or wortmannin-sensitive manner.
Class A scavenger receptors mediate cell adhesion via activation of G(i/o) and formation of focal adhesion complexes.
Clinical and Histopathological Assessment on an Animal Model with Experimental Autoimmune Encephalomyelitis.
Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye.
Clinical experience of a tricomponent acellular pertussis vaccine combined with diphtheria and tetanus toxoids for primary vaccination in 22,505 infants.
Clinical reactions and immunogenicity of the BIKEN acellular diphtheria and tetanus toxoids and pertussis vaccine in 4- through 6-year-old US children.
Clinical validation of a polymerase chain reaction assay for the diagnosis of pertussis by comparison with serology, culture, and symptoms during a large pertussis vaccine efficacy trial.
Clinical, metabolic, and antibody responses of adult volunteers to an investigational vaccine composed of pertussis toxin inactivated by hydrogen peroxide.
Clinicopathological study of a myelin oligodendrocyte glycoprotein-induced demyelinating disease in LEW.1AV1 rats.
Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover.
Clonidine and cirazoline inhibit activation of nicotinic channels in PC-12 cells.
Clonidine inhibits fluid absorption in the rabbit proximal convoluted renal tubule.
Cloning and characterization of a cDNA coding for the alpha-subunit of a stimulatory G protein from Schistosoma mansoni.
Cloning and characterization of a G protein alpha-subunit-encoding gene from the basidiomycete, Coprinus congregatus.
Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.
Cloning and Expression of S1 Subunit of Pertussis Toxin in Escherichia coli.
Cloning and functional characterization of the mouse C3a anaphylatoxin receptor gene.
Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor.
Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.
Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES.
Cloning and functional expression of the first Drosophila melanogaster sulfakinin receptor DSK-R1.
Cloning and pharmacological characterisation of the guinea pig 5-ht5A receptor.
Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.
Cloning of a molluscan G protein alpha subunit of the Gq class which is expressed differentially in identified neurons.
Cloning, expression and regulation of angiotensin II receptors.
Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes.
Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain.
Cloning, expression, functional coupling and pharmacological characterization of the rat dopamine D4 receptor.
Cloning, heterologous expression and developmental regulation of a Drosophila receptor for tachykinin-like peptides.
Cloning, nucleotide sequence, and hybridization studies of the type IIb heat-labile enterotoxin gene of Escherichia coli.
Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor.
Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation.
Clostridium difficile toxin A stimulates intracellular calcium release and chemotactic response in human granulocytes.
Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes.
Clostridium perfringens alpha-toxin induces rabbit neutrophil adhesion.
Clustered cases of Bordetella pertussis infection cause high levels of IgG antibodies against pertussis toxin in adolescents in Gaobeidian city, China.
Clusterin stimulates the chemotactic migration of macrophages through a pertussis toxin sensitive G-protein-coupled receptor and G??-dependent pathways.
cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects.
CNP-induced changes in pHi, cGMP/cAMP and mRNA expression of natriuretic peptide receptors in human trabecular meshwork cells.
Co-existence of two types of [Ca2+]i-inducing protease-activated receptors (PAR-1 and PAR-2) in rat astrocytes and C6 glioma cells.
Co-expression of mu and delta opioid receptors as receptor-G protein fusions enhances both mu and delta signalling via distinct mechanisms.
Co-expression of the Bordetella pertussis leader peptidase I results in enhanced processing and expression of the pertussis toxin S1 subunit in Escherichia coli.
Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in the formylmethionyl-leucylphenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate in human neutrophils.
Co-purification of A1 adenosine receptors and guanine nucleotide-binding proteins from bovine brain.
Co-stimulation of PAFR and CD36 is required for oxLDL-induced human macrophages activation.
Co-stimulation of T cells via CD28 inhibits human IgE production; reversal by pertussis toxin.
Coagulation Factor Xa inhibits cancer cell migration via Protease-activated receptor-1 activation.
Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors.
Codeine induces human mast cell chemokine and cytokine production: involvement of G-protein activation.
Coexistence of CD14-dependent and independent pathways for stimulation of human monocytes by gram-positive bacteria.
Coexisting NPY and NE synergistically regulate renal tubular Na+, K(+)-ATPase activity.
Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory.
Coexpression of ligand-gated P2X and G protein-coupled P2Y receptors in smooth muscle. Preferential activation of P2Y receptors coupled to phospholipase C (PLC)-beta1 via Galphaq/11 and to PLC-beta3 via Gbetagammai3.
Coexpression of several types of metabotropic nucleotide receptors in single cerebellar astrocytes.
Coexpression of Y1, Y2, and Y4 receptors in smooth muscle coupled to distinct signaling pathways.
Coincidence detection at the level of phospholipase C activation mediated by the m4 muscarinic acetylcholine receptor.
Colchicine and cytochalasin B enhance cyclic AMP accumulation via postreceptor actions.
Cold-induced reduction in Gi alpha proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussis-toxin treatment.
Collaborative study for the calibration of the replacement International Standard for pertussis toxin for use in histamine sensitisation and CHO cell clustering assays.
Collaborative study for the establishment of a European Phamacopoeia Biological reference preparation for Bordetella pertussis mouse antiserum for serological potency testing of acellular pertussis vaccines.
Collaborative study for the evaluation of enzyme-linked immunosorbent assays used to measure human antibodies to Bordetella pertussis antigens.
Collaborative Study for the Standardisation of the Histamine Sensitizing Test in Mice and the CHO Cell-based Assay for the Residual Toxicity Testing of Acellular Pertussis Vaccines.
Collaborative study on a Guinea pig serological method for the assay of acellular pertussis vaccines.
Collaborative study on test systems to assess toxicity of whole cell pertussis vaccine.
Collagen Synthesis Is Suppressed in Dermal Fibroblasts by the Human Antimicrobial Peptide LL-37.
Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C.
Collagen-binding motif peptide, a cleavage product of osteopontin, stimulates human neutrophil chemotaxis via pertussis toxin-sensitive G protein-mediated signaling.
Colocalization and complex formation between prosaposin and monosialoganglioside GM3 in neural cells.
Colonic smooth muscle cells possess a different subtype of somatostatin receptor from gastric smooth muscle cells.
Colony-stimulating factor 1 activates protein kinase C in human monocytes.
Colony-stimulating factor 1-induced Na+ influx into human monocytes involves activation of a pertussis toxin-sensitive GTP-binding protein.
Combined pharmacological preconditioning with a G-protein-coupled receptor agonist, a mitochondrial KATP channel opener and a nitric oxide donor mimics ischaemic preconditioning.
Combined tetanus-diphtheria and pertussis vaccine during pregnancy: transfer of maternal pertussis antibodies to the newborn.
Commensal-Epithelial Signaling Mediated via Formyl Peptide Receptors.
Common alpha 2- and opiate effector mechanisms in the locus coeruleus: intracellular studies in brain slices.
Common ancestry between IncN conjugal transfer genes and macromolecular export systems of plant and animal pathogens.
Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.
Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins.
Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.
Comodulation of CXCR4 and CD26 in human lymphocytes.
Comparative aspects of the role of neuropeptide Y in the regulation of the vertebrate heart.
Comparative biological activities of whole cell pertussis vaccine and a new acellular preparation.
Comparative effects of cholera and Bordetella pertussis toxins on cyclic AMP and GTP levels and on lipolysis in rat adipocytes incubated in vitro.
Comparative effects of receptor inactivation, 17 beta-estradiol and pertussis toxin on dopaminergic inhibition of prolactin secretion in vitro.
Comparative efficacy of acellular pertussis vaccines: an analysis of recent trials.
Comparative evaluation of Mycobacterium vaccae as a surrogate cloning host for use in the study of mycobacterial genetics.
Comparative genomic profiling of Dutch clinical Bordetella pertussis isolates using DNA microarrays: identification of genes absent from epidemic strains.
Comparative genomics of prevaccination and modern Bordetella pertussis strains.
Comparative safety and immunogenicity of an acellular versus whole-cell pertussis component of diphtheria-tetanus-pertussis vaccines in Senegalese infants.
Comparative studies of phosphoinositide hydrolysis induced by endothelin-related peptides in cultured cerebellar astrocytes, C6-glioma and cerebellar granule cells.
Comparative studies on the binding specificities of pertussis toxin and different lectins to human erythrocytes.
Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine. The Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine.
Comparative study of different sources of pertussis toxin (PT) as coating antigens in IgG anti-PT enzyme-linked immunosorbent assays.
Comparing the pathogenesis of experimental autoimmune encephalomyelitis in CD4-/- and CD8-/- DBA/1 mice defines qualitative roles of different T cell subsets.
Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin.
Comparison of 13 acellular pertussis vaccines: overview and serologic response.
Comparison of a diphtheria and tetanus toxoids and bicomponent acellular pertussis vaccine with diphtheria and tetanus toxoids and whole-cell pertussis vaccine in infants.
Comparison of a fifth dose of a five-component acellular or a whole cell pertussis vaccine in children four to six years of age.
Comparison of a three-component acellular pertussis vaccine with a whole-cell pertussis vaccine in 4- through 6-year-old children. Elmwood Pediatric Associates, Pennridge Pediatric Associates.
Comparison of a three-component acellular pertussis vaccine with whole cell pertussis vaccine in two-month-old children.
Comparison of acellular pertussis vaccine with whole cell vaccine as a booster in children 15 to 18 months and 4 to 6 years of age.
Comparison of acellular pertussis vaccines-induced immunity against infection due to Bordetella pertussis variant isolates in a mouse model.
Comparison of alpha 1-adrenergic receptor subtypes and signal transduction in SK-N-MC and NB41A3 neuronal cell lines.
Comparison of alpha 1A- and alpha 1B-adrenoceptor coupling to inositol phosphate formation in rat kidney.
Comparison of anti-pertussis toxin ELISA and agglutination assays to assess immune responses to pertussis.
Comparison of autocrine mechanisms promoting motility in two metastatic cell lines: human melanoma and ras-transfected NIH3T3 cells.
Comparison of culture and PCR for detection of Bordetella pertussis and Bordetella parapertussis under routine laboratory conditions.
Comparison of diphtheria-tetanus-two component acellular pertussis vaccines in United States and Japanese infants at 2, 4, and 6 months of age.
Comparison of endothelium-dependent relaxation in carotid arteries from Japanese white and Watanabe heritable hyperlipidemic rabbits.
Comparison of extracellular ATP and UTP signalling in rat renal mesangial cells. No indications for the involvement of separate purino- and pyrimidino-ceptors.
Comparison of five calculation modes for antibody ELISA procedures using pertussis serology as a model.
Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea.
Comparison of functional profiles at human recombinant somatostatin sst2 receptor: simultaneous determination of intracellular Ca2+ and luciferase expression in CHO-K1 cells.
Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells.
Comparison of mechanisms of IL-3 induced histamine release and IL-3 priming effect on human basophils.
Comparison of mu opioid receptor binding on intact neuroblastoma cells with guinea pig brain and neuroblastoma cell membranes.
Comparison of nasopharyngeal culture, polymerase chain reaction (PCR) and serological test for diagnosis of pertussis.
Comparison of pertussis toxin (PT)-neutralizing activities and mouse-protective activities of anti-PT mouse monoclonal antibodies.
Comparison of polymerase chain reaction, culture, and western immunoblot serology for diagnosis of Bordetella pertussis infection.
Comparison of real-time PCR and pyrosequencing for typing Bordetella pertussis toxin subunit 1 variants.
Comparison of second messenger formation in human keratinocytes following stimulation with epidermal growth factor and bradykinin.
Comparison of sensitization elicited by amphetamine and pertussis toxin: characterization of locomotor behavior and limbic dopamine release.
Comparison of serological and real-time PCR assays to diagnose Bordetella pertussis infection in 2007.
Comparison of signal transduction mechanisms of alpha-2C and alpha-1A adrenergic receptor-stimulated prostaglandin synthesis.
Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes.
Comparison of stimulation by chemotactic formyl peptide analogs between GTPase activity in neutrophil plasma membranes and granule enzyme release from intact neutrophils.
Comparison of the actions of adenosine at pre- and postsynaptic receptors in the rat hippocampus in vitro.
Comparison of the actions of baclofen at pre- and postsynaptic receptors in the rat hippocampus in vitro.
Comparison of the bioactivity of reference preparations for assaying Bordetella pertussis toxin activity in vaccines by the histamine sensitisation and Chinese hamster ovary-cell tests: assessment of validity of expression of activity in terms of protein concentration.
Comparison of the Bordetella pertussis and Bordetella parapertussis isolates circulating in Saint Petersburg between 1998 and 2000 with Russian vaccine strains.
Comparison of the effects of ions and GTP on substance P binding to membrane-bound and solubilized specific sites.
Comparison of the lectin-like activity of pertussis toxin with two plant lectins that have differential specificities for alpha (2-6) and alpha (2-3)-linked sialic acid.
Comparison of the ligand binding and signaling properties of human dopamine D(2) and D(3) receptors in Chinese hamster ovary cells.
Comparison of the pharmacological antagonism of M2 and M3 muscarinic receptors expressed in isolation and in combination.
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.
Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation.
Comparison of the safety and immunogenicity of acellular (BIKEN) and whole-cell pertussis vaccines in 15- to 20-month-old children.
Comparison of the timing of acute blood-brain barrier breakdown to rabbit immunoglobulin G in the cerebellum and spinal cord of mice with experimental autoimmune encephalomyelitis.
Compartmentation of alpha 2-adrenergic receptors in human erythroleukemia (HEL) cells.
Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors.
Competition between zonae pellucidae and a proteinase inhibitor for sperm binding.
Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton.
Complement c3a and c5a induce different signal transduction cascades in endothelial cells.
Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammation.
Complement fragment C3a stimulates Ca2+ influx in neutrophils via a pertussis-toxin-sensitive G protein.
Complement selectively elicits glutamate release from nerve endings in different regions of mammal central nervous system.
Complete inhibition of purinoceptor agonist-induced nociception by spinorphin, but not by morphine.
Complex chemoattractive and chemorepellent Kit signals revealed by direct imaging of murine mast cells in microfluidic gradient chambers.
Complex involvement of pertussis toxin-sensitive G proteins in the regulation of type 1alpha metabotropic glutamate receptor signaling in baby hamster kidney cells.
Complex regulation of calcium current in cardiac cells. Dependence on a pertussis toxin-sensitive substrate, adenosine triphosphate, and an alpha 1-adrenoceptor.
Components of purified sarcolemma from porcine skeletal muscle.
Components of the signaling pathway linking the 1-methyladenine receptor to MPF activation and maturation in starfish oocytes.
Computational evaluation of a fusion protein consisted of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis to target Claudin-4 using C-terminal fragment of Clostridium perfringens enterotoxin.
Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding.
Concanavalin A stimulation of O2 consumption in electropermeabilized neutrophils via a pertussis toxin-insensitive G protein.
Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae.
Concentrations of Immunoglobulin G Antibodies Against Pertussis Toxin Does Not Decrease Over a Long Period of Time in Japan.
Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression.
Concomitant regulation of Ca2+ mobilization and G13 expression in human erythroleukemia cells.
Concomitant treatment with pertussis toxin plus temozolomide increases the survival of rats bearing intracerebral RG2 glioma.
Concomitant use of VAQTA® with PedvaxHIB® and Infanrix® in 12 to 17 month old children.
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor.
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?
Conditional activation of cAMP signal transduction by protein kinase C. The effect of phorbol esters on adenylyl cyclase in permeabilized and intact cells.
Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.
Conditional transformation mediated via a pertussis toxin-sensitive receptor signalling pathway.
Confocal microscopy study of pertussis toxin and toxoids on CHO-cells.
Conformational dependence of collagenase (matrix metalloproteinase-1) up-regulation by elastin peptides in cultured fibroblasts.
Conformational dynamics of Kir3.1/Kir3.2 channel activation via ?-opioid receptors.
Conformational study of a short Pertussis toxin T cell epitope incorporated in a multiple antigen peptide template by CD and two-dimensional NMR. Analysis of the structural effects on the activity of synthetic immunogens.
Conformations of the alpha 39, alpha 41, and beta.gamma components of brain guanine nucleotide-binding proteins. Analysis by limited proteolysis.
Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes.
Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes.
Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.
Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines.
Conjugated linoleic acid isomers and trans fatty acids inhibit fatty acid transport in hepatoma 7288CTC and inguinal fat pads in Buffalo rats.
Connective tissue and its growth factor CTGF distinguish the morphometric and molecular remodeling of the bladder in a model of neurogenic bladder.
Conservation of a common motif in enzymes catalyzing ADP-ribose transfer. Identification of domains in mammalian transferases.
Conserved transducer coupling but different effector linkage upon expression of the myeloid fMet-Leu-Phe receptor in insulin secreting cells.
Consistent induction of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice for the longitudinal study of pathology and repair.
Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus involve G alpha(13) and RhoA.
Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression.
Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors.
Constitutive activity of human prostaglandin E receptor EP3 isoforms.
Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists.
Constitutive chemokine production results in activation of leukocyte function-associated antigen-1 on adult T-cell leukemia cells.
Constitutive G(i2)-dependent activation of adenylyl cyclase type II by the 5-HT1A receptor. Inhibition by anxiolytic partial agonists.
Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.
Constitutive inositol phosphate formation in cytomegalovirus-infected human fibroblasts is due to expression of the chemokine receptor homologue pUS28.
Constitutive precoupling to G(i) and increased agonist potency in the alpha(2B)-adrenoceptor.
Constitutive somatostatin receptor activity determines tonic pituitary cell response.
Constitutively active mutants of the alpha 2-adrenergic receptor.
Construction and characterisation of Salmonella typhimurium aroA simultaneously expressing the five pertussis toxin subunits.
Construction and characterization of Bordetella pertussis toxin mutants.
Construction and characterization of genetically inactivated pertussis toxin.
Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin.
Construction of an unmarked recombinant BCG expressing a pertussis antigen by auxotrophic complementation: Protection against Bordetella pertussis challenge in neonates.
Construction of Bordetella pertussis strains that overproduce genetically inactivated pertussis toxin.
Construction of Bordetella pertussis strains with enhanced production of genetically-inactivated Pertussis Toxin and Pertactin by unmarked allelic exchange.
Construction of minitransposons for constitutive and inducible expression of pertussis toxin in bvg-negative Bordetella bronchiseptica.
Contact-activated migration of melanoma B16 and sarcoma XC cells.
Continuous activation of pituitary adenylate cyclase-activating polypeptide receptors elicits antipodal effects on cyclic AMP and inositol phospholipid signaling pathways in CATH.a cells: role of protein synthesis and protein kinases.
Continuous intrathecal opioid treatment abolishes the regulatory effects of magnesium and guanine nucleotides on mu opioid receptor binding in rat spinal membranes.
Contractile function and response to agonists in myocytes from failing human heart.
Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle.
Contractile roles of the M2 and M3 muscarinic receptors in the guinea pig colon.
Contrary effects of sphingosine-1-phosphate on expression of ?-smooth muscle actin in transforming growth factor ?1-stimulated lung fibroblasts.
Contribution of cAMP to the inhibitory effect of non-steroidal anti-inflammatory drugs in rat uterine smooth muscle.
Contribution of extracellular signal-regulated kinase to UTP-induced interleukin-6 biosynthesis in HaCaT keratinocytes.
Contribution of Kir3.1, Kir3.2A and Kir3.2C subunits to native G protein-gated inwardly rectifying potassium currents in cultured hippocampal neurons.
Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs.
Contribution of membrane progesterone receptor ? to the induction of progesterone-mediated apoptosis associated with mitochondrial membrane disruption and caspase cascade activation in Jurkat cell lines.
Contribution of pertussis toxin to the pathogenesis of pertussis disease.
Contribution of the B oligomer to the protective activity of genetically attenuated pertussis toxin.
Contribution of the extracellular cAMP-adenosine pathway to dual coupling of ?2-adrenoceptors to Gs and Gi proteins in mouse skeletal muscle.
Control of aldosterone production by angiotensin II is mediated by two guanine nucleotide regulatory proteins.
Control of cyclic adenosine 3',5'-monophosphate production in osteoclasts: calcitonin-induced persistent activation and homologous desensitization of adenylate cyclase.
Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells.
Control of PTH secretion is mediated through calcium channels and is blocked by pertussis toxin treatment of parathyroid cells.
Control of the amiloride-sensitive Na+ current in mouse salivary ducts by intracellular anions is mediated by a G protein.
Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells.
Control of voltage-dependent Ca2+ channels by G protein-coupled receptors.
Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor.
Conversion of adrenergic mechanism from an alpha- to a beta-type during primary culture of rat hepatocytes. Accompanying decreases in the function of the inhibitory guanine nucleotide regulatory component of adenylate cyclase identified as the substrate of islet-activating protein.
Cooperation between thrombospondin-1 type 1 repeat peptides and alpha(v)beta(3) integrin ligands to promote melanoma cell spreading and focal adhesion kinase phosphorylation.
Cooperation of G12/13 and Gi proteins via lysophosphatidic acid receptor-2 (LPA2) signaling enhances cancer cell survival to cisplatin.
Cooperation of Gq, Gi, and G12/13 in protein kinase D activation and phosphorylation induced by lysophosphatidic acid.
Cooperation of thyrotropin, but not basic fibroblast growth factor, with an adenosine receptor agonist in Ca2+ mobilization from thapsigargin-sensitive pools in single FRTL-5 thyroid cells.
Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity.
Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11).
Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.
Copresence of prostaglandin EP2 and EP3 receptors on gastric enterochromaffin-like cell carcinoid in African rodents.
Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.
Coronary arteriolar dilation to acidosis: role of ATP-sensitive potassium channels and pertussis toxin-sensitive G proteins.
Correlation between behavioral sensitization to cocaine and G protein ADP-ribosylation in the ventral tegmental area.
Correlation between chemotactic peptide-induced changes in chlorotetracycline fluorescence and F-actin content in human neutrophils: a role for membrane-associated calcium in the regulation of actin polymerization?
Correlation between keratinocyte expression of Ia and the intensity and duration of contact hypersensitivity responses in mice.
Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity.
Correlation between pertussis toxin IgG antibodies in postvaccination sera and subsequent protection against pertussis.
Correlation between ribosylation of pertussis toxin substrates and inhibition of peptidoglycan-, muramyl dipeptide- and lipopolysaccharide-induced mitogenic stimulation in B lymphocytes.
Correlation of IgA, IgM and IgG antibody-detecting assays based on filamentous haemagglutinin, pertussis toxin and Bordetella pertussis sonicate in a strictly adult population.
Corrigendum to "Accelerated maternal responding following intra-VTA pertussis toxin treatment" [Behav. Brain Res. 223 (October (2)) (2011) 322-328; Epub 2011 May 6].
Corticotropin releasing factor-induced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2.
Corticotropin-releasing factor increases [Ca2+]i via receptor-mediated Ca2+ channels in human epidermoid A-431 cells.
Corticotropin-releasing factor induces phosphorylation of phospholipase C-gamma at tyrosine residues via its receptor 2beta in human epidermoid A-431 cells.
Corticotropin-releasing factor receptors and actions in rat Leydig cells.
Corticotropin-releasing factor-like peptides increase cytosolic [Ca2+] in human epidermoid A-431 cells.
Corticotropin-releasing factor: an antireproductive hormone of the testis.
Cortisol inhibition of calcium currents in guinea pig hippocampal CA1 neurons via G-protein-coupled activation of protein kinase C.
Cortisol inhibition of growth hormone-releasing hormone-stimulated growth hormone release from cultured sheep pituitary cells.
Cough production, leucocytosis and serology of rats infected intrabronchially with Bordetella pertussis.
Could dual G-protein coupling explain [D-Met2]FMRFamide's mixed action in vivo?
Coupling between inositol phosphate formation and DNA synthesis in smooth muscle cells stimulated with neurokinin A.
Coupling between phosphoinositide breakdown and early mitogenic events in fibroblasts. Studies with fluoroaluminate, vanadate, and pertussis toxin.
Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy.
Coupling function of endogenous alpha(1)- and beta-adrenergic receptors in mouse cardiomyocytes.
Coupling mechanisms of alpha 2-adrenoceptors.
Coupling of 5-HT1A autoreceptors to inhibition of mitogen-activated protein kinase activation via G beta gamma subunit signaling.
Coupling of a cloned rat dopamine-D2 receptor to inhibition of adenylyl cyclase and prolactin secretion.
Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.
Coupling of a purified goldfish brain kainate receptor with a pertussis toxin-sensitive G protein.
Coupling of a transfected human brain A1 adenosine receptor in CHO-K1 cells to calcium mobilisation via a pertussis toxin-sensitive mechanism.
Coupling of adenosine A1 receptors to a G-protein in coated vesicles isolated from bovine brain: presence of pertussis and cholera toxin substrates.
Coupling of adenosine receptors to a pertussis toxin-sensitive G protein in the human heart.
Coupling of Airway Smooth Muscle TAS2Rs to Intracellular Signaling and Relaxation is via G?i1,2,3.
Coupling of an endogenous 5-HT1B-like receptor to increases in intracellular calcium through a pertussis toxin-sensitive mechanism in CHO-K1 cells.
Coupling of antagonistic signalling pathways in modulation of neutrophil function.
Coupling of beta-adrenergic receptors to cardiac L-type Ca2+ channels: preferential coupling of the beta1 versus beta2 receptor subtype and evidence for PKA-independent activation of the channel.
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes.
Coupling of bradykinin receptors to phospholipase C in cultured fibroblasts is mediated by a G-protein.
Coupling of canine serotonin 5-HT(1B) and 5-HT(1D) receptor subtypes to the formation of inositol phosphates by dual interactions with endogenous G(i/o) and recombinant G(alpha15) proteins.
Coupling of ETB endothelin receptor to mitogen-activated protein kinase stimulation and DNA synthesis in primary cultures of rat astrocytes.
Coupling of exogenous receptors to phospholipase C in Xenopus oocytes through pertussis toxin-sensitive and -insensitive pathways. Cross-talk through heterotrimeric G-proteins.
Coupling of expressed alpha 1B- and alpha 1D-adrenergic receptor to multiple signaling pathways is both G protein and cell type specific.
Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors.
Coupling of guanine nucleotide inhibitory protein to somatostatin receptors on pancreatic acinar membranes.
Coupling of hepatic prostaglandin receptors to adenylate cyclase through a pertussis toxin sensitive guanine nucleotide regulatory protein.
Coupling of human alpha 2-adrenoceptor subtypes to regulation of cAMP production in transfected S115 cells.
Coupling of human D-1 dopamine receptors to different guanine nucleotide binding proteins. Evidence that D-1 dopamine receptors can couple to both Gs and G(o).
Coupling of human delta-opioid receptor to retinal rod transducin in Chinese hamster ovary cells.
Coupling of I(1) imidazoline receptors to the cAMP pathway: studies with a highly selective ligand, benazoline.
Coupling of inhibitory receptors with Gi-proteins in hamster adipocytes: comparison between adenosine A1 receptor and alpha 2-adrenoceptor.
Coupling of m2 and m4 muscarinic acetylcholine receptor subtypes to Ca(2+)-dependent K+ channels in transformed NL308 neuroblastoma x fibroblast hybrid cells.
Coupling of metabotropic glutamate receptor 8 to N-type Ca2+ channels in rat sympathetic neurons.
Coupling of muscarinic m1, m2 and m3 acetylcholine receptors, expressed in Chinese hamster ovary cells, to pertussis toxin-sensitive/insensitive guanine nucleotide-binding proteins.
Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction.
Coupling of serotonin 5-HT1B receptors to activation of mitogen-activated protein kinase (ERK-2) and p70 S6 kinase signaling systems.
Coupling of TGF-beta-induced mitogenesis to G-protein activation in AKR-2B cells.
Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells.
Coupling of the C5a receptor to Gi in U-937 cells and in cells transfected with C5a receptor cDNA.
Coupling of the cloned mu-opioid receptor with the omega-conotoxin-sensitive Ca2+ current in NG108-15 cells.
Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go.
Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction.
Coupling of the human A1 adenosine receptor to different heterotrimeric G proteins: evidence for agonist-specific G protein activation.
Coupling of the human Y2 receptor for neuropeptide Y and peptide YY to guanine nucleotide inhibitory proteins in permeabilized SMS-KAN cells.
Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growth.
Coupling of the muscarinic m2 receptor to G protein-activated K(+) channels via Galpha(z) and a receptor-Galpha(z) fusion protein. Fusion between the receptor and Galpha(z) eliminates catalytic (collision) coupling.
Coupling of the nucleotide P2Y4 receptor to neuronal ion channels.
Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells.
Coupling of the thyrotropin-releasing hormone receptor to phospholipase C by a GTP-binding protein distinct from the inhibitory or stimulatory GTP-binding protein.
Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells.
Coupling specificity of NOP opioid receptors to pertussis-toxin-sensitive Galpha proteins in adult rat stellate ganglion neurons using small interference RNA.
Coupling to Gs and G(q/11) of histamine H2 receptors heterologously expressed in adult rat atrial myocytes.
Covalent cross-linking of prostaglandin E receptor from bovine adrenal medulla with a pertussis toxin-insensitive guanine nucleotide-binding protein.
CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein- coupled receptor mFPR2.
CR4056, a powerful analgesic imidazoline-2 receptor ligand, inhibits the inflammation-induced PKC? phosphorylation and membrane translocation in sensory neurons.
Crawling phagocytes recruited in the brain vasculature after pertussis toxin exposure through IL6, ICAM1, and ITG?M.
CRF1 Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms.
Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability.
Critical role of L-selectin and histamine H4 receptor in zymosan-induced neutrophil recruitment from the bone marrow: comparison with carrageenan.
Critical role of methionine-722 in the stimulation of human brain G-proteins and neurotoxicity induced by London familial Alzheimer's disease (FAD) mutated V717G-APP(714-723).
Critical role of the chymase/angiotensin-(1-12) axis in modulating cardiomyocyte contractility.
Cross talk between stimulatory and inhibitory guanosine 5'-triphosphate binding proteins: role in activation and desensitization of the adenylate cyclase response to vasopressin.
Cross talk between substance P and melittin-activated cellular signaling pathways in rat lactotroph-enriched cell cultures.
Cross-linking a maturation-dependent ram sperm plasma membrane antigen induces the acrosome reaction.
Cross-linking of G-proteins to the prolactin receptor in rat NB2 lymphoma cells.
Cross-regulation of VPAC2 receptor internalization by m2 receptors via c-Src-mediated phosphorylation of GRK2.
Cross-talk among epidermal growth factor, Ap(5)A, and nucleotide receptors causing enhanced ATP Ca(2+) signaling involves extracellular kinase activation in cerebellar astrocytes.
Cross-talk between Ca2+ influx and phosphoinositide hydrolysis by extracellular adenosine triphosphate in rat PC12 pheochromocytoma cells.
Cross-talk between glucagon- and adenosine-mediated signalling systems in rat hepatocytes: effects on cyclic AMP-phosphodiesterase activity.
Cross-talk between metabotropic glutamate receptor 7 and beta adrenergic receptor signaling at cerebrocortical nerve terminals.
Cross-talk between TGF-?1 and Muscarinic M2 Receptors Augments Airway Smooth Muscle Proliferation.
Cross-talk of parathyroid hormone-responsive dual signal transduction systems in osteoblastic osteosarcoma cells: its role in PTH-induced homologous desensitization of intracellular calcium response.
Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes.
Crosstalk between CXCR4/stromal derived factor-1 and VLA-4/VCAM-1 pathways regulates neutrophil retention in the bone marrow.
Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP.
Crosstalk of sterol-dependent and non-sterol-dependent signaling in human monocytes after in vitro addition of LDL.
Cryptic gonadotropin-releasing hormone receptors of rat pituitary cells in culture are unmasked by epidermal growth factor.
Cryptide signaling: Amphiphilic peptide-induced exocytotic mechanisms in mast cells.
Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation.
Crystal structure of the pertussis toxin-ATP complex: a molecular sensor.
Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals.
Crystal-induced neutrophil activation. II. Evidence for the activation of a phosphatidylcholine-specific phospholipase D.
Curosurf modulates cAMP accumulation in human monocytes through a membrane-controlled mechanism.
Cutting edge: C-C chemokine receptor 6 is essential for arrest of a subset of memory T cells on activated dermal microvascular endothelial cells under physiologic flow conditions in vitro.
Cutting edge: CCR4 mediates antigen-primed T cell binding to activated dendritic cells.
Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling.
Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages.
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.
CX3C-chemokine, fractalkine-enhanced adhesion of THP-1 cells to endothelial cells through integrin-dependent and -independent mechanisms.
CXC chemokine receptor 4 expression and function in human anaplastic thyroid cancer cells.
CXC chemokine receptor 4 signaling upon co-activation with stromal cell-derived factor-1? and ubiquitin.
CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro.
CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity.
CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through bim-mediated intrinsic apoptosis.
CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph nodes.
CXCL12-mediated induction of plasminogen activator inhibitor-1 expression in human CXCR4 positive astroglioma cells.
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3.
CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo.
CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways.
CXCR3 internalization following T cell-endothelial cell contact: preferential role of IFN-inducible T cell alpha chemoattractant (CXCL11).
CXCR3 is involved in tubulointerstitial injury in human glomerulonephritis.
CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase.
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.
CXCR4 chemokine receptors (CD184) and alpha4beta1 integrins mediate spontaneous migration of human CD34+ progenitors and acute myeloid leukaemia cells beneath marrow stromal cells (pseudoemperipolesis).
Cyclic adenosine 3',5'-monophosphate metabolism in activated T-cell clones.
Cyclic AMP can partially restore platelet-derived growth factor-stimulated prostaglandin E2 biosynthesis, and calcium mobilization in EJ-ras-transformed NIH-3T3 cells.
Cyclic AMP content and invasive capacity of metastatic variants of the BW-5147 murine T-cell lymphoma.
Cyclic AMP counteracts mitogen-induced inositol phosphate generation and increases in intracellular Ca2+ concentrations in human lymphocytes.
Cyclic AMP differentiates two separate but interacting pathways of phosphoinositide hydrolysis in the DDT1-MF2 smooth muscle cell line.
Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling.
Cyclic AMP levels in lung and spleen tissue of mice treated with pertussis toxin.
Cyclic AMP mediates keratinocyte directional migration in an electric field.
Cyclic AMP regulates the calcium transients released from IP(3)-sensitive stores by activation of rat kappa-opioid receptors expressed in CHO cells.
Cyclic AMP-dependent induction of serotonin N-acetyltransferase activity in photoreceptor-enriched chick retinal cell cultures: characterization and inhibition by dopamine.
Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i) -dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle.
Cyclic AMP-dependent regulation of the number of [3H]batrachotoxinin benzoate binding sites on rat cardiac myocytes.
Cyclic AMP-independent, dual regulation of voltage-dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line.
Cyclic GMP-dependent protein kinase blocks pertussis toxin-sensitive hormone receptor signaling pathways in Chinese hamster ovary cells.
Cyclic guanosine monophosphate analogs do not reverse bacterial toxin modulation of lactogen-stimulated NB2 cell mitogenesis.
Cyclic phosphatidic acid elicits neurotrophin-like actions in embryonic hippocampal neurons.
Cyclic strain-mediated regulation of endothelial matrix metalloproteinase-2 expression and activity.
Cyclic strain-mediated regulation of vascular endothelial cell migration and tube formation.
Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells.
Cyclic tensile stretch inhibition of nitric oxide release from osteoblast-like cells is both G protein and actin-dependent.
Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit.
Cycloheximide abolishes pertussis toxin induced increase in glutamate release from cerebellar granule neurones.
Cycloheximide abolishes pertussis toxin-induced increase in glutamate release from cerebellar granule neurones.
CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation.
CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras.
Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils.
Cytochalasin B enhancement of the diacylglycerol response in formyl peptide-stimulated neutrophils.
Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils.
Cytochalasin-induced nitroblue tetrazolium dye (NBT) reduction in polymorphonuclear leukocytes.
Cytodifferentiation Enhances Erk Activation Induced by Endothelin-1 in Primary Cultured Astrocytes.
Cytokine and chemokine based control of HIV infection and replication.
Cytokine mRNA expression and proliferative responses induced by pertussis toxin, filamentous hemagglutinin, and pertactin of Bordetella pertussis in the peripheral blood mononuclear cells of infected and immunized schoolchildren and adults.
Cytokine regulation of adenylate cyclase activity in LLC-PK1 cells.
Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2.
Cytokines inhibit proliferation and insulin secretion by clonal rat insulinoma cells (RINm5F) non-synergistically and in a pertussis toxin-insensitive manner.
Cytomegalovirus induction of interleukin-6 in lung fibroblasts occurs independently of active infection and involves a G protein and the transcription factor, NF-kappaB.
Cytoplasmic domain of natriuretic peptide receptor C constitutes Gi activator sequences that inhibit adenylyl cyclase activity.
Cytoplasmic domain of natriuretic peptide receptor-C inhibits adenylyl cyclase. Involvement of a pertussis toxin-sensitive G protein.
Cytoplasmic kinase and phosphatase activities can induce PsaF gene expression in the absence of functional plastids: evidence that phosphorylation/dephosphorylation events are involved in interorganellar crosstalk.
Cytoplasmic pH change induced by leukotriene B4 in human neutrophils.
Cytoplasmic pH regulation in activated human neutrophils: effects of adenosine and pertussis toxin on Na+/H+ exchange and metabolic acidification.
Cytoskeletal alterations as a parameter for assessment of toxicity.
Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase.
Cytosol promotes the guanine nucleotide-induced release of the alpha subunit of Gi2 from the membrane of mouse mastocytoma P-815 cells.
Cytosolic Na+ controls and epithelial Na+ channel via the Go guanine nucleotide-binding regulatory protein.
Cytosolic phospholipase C activity: I. Evidence for coupling with cytosolic guanine nucleotide-binding protein, Gi alpha.
Cytotoxic action of lindane in cerebellar granule neurons is mediated by interaction with inducible GABA(B) receptors.
Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant.
Cytotoxicity of intracellular a?42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate.
D-2 dopamine receptor activation reduces free [3H]arachidonate release induced by hypophysiotropic peptides in anterior pituitary cells.
D-2 dopamine receptor-mediated inhibition of pro-opiomelanocortin synthesis in rat intermediate lobe. Abolition by pertussis toxin or activators of adenylate cyclase.
D-2-amino-5-phosphonopentanoic acid inhibits intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cgamma up-regulation.
D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells.
D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3.
D1 agonist-induced excitation of substantia nigra pars reticulata neurons: mediation by D1 receptors on striatonigral terminals via a pertussis toxin-sensitive coupling pathway.
D1 dopamine receptors can interact with both stimulatory and inhibitory guanine nucleotide binding proteins.
D2 dopamine receptor stimulation of mitogenesis in transfected Chinese hamster ovary cells: relationship to dopamine stimulation of tyrosine phosphorylations.
D2 dopamine receptor-mediated antiproliferation in a small cell lung cancer cell line, NCI-H69.
D2 dopamine receptors interact directly with N-type calcium channels and regulate channel surface expression levels.
D2 dopamine receptors modulate Galpha-subunit coupling of the CB1 cannabinoid receptor.
D2 dopamine receptors stimulate mitogenesis through pertussis toxin-sensitive G proteins and Ras-involved ERK and SAP/JNK pathways in rat C6-D2L glioma cells.
D2 dopaminergic receptors: normal and abnormal transduction mechanisms.
D2 inhibition of stimulated Fos immunoreactivity in cultured tyrosine hydroxylase-ir hypothalamic neurons.
D2 receptors mediate dopamine suppression of irANF release and pro-ANF mRNA expression of rat hypothalamic neurons in culture.
D2, D3, and D4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes.
D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels.
D2L, D2S, and D3 dopamine receptors stably transfected into NG108-15 cells couple to a voltage-dependent potassium current via distinct G protein mechanisms.
D2S, D2L, D3, and D4 dopamine receptors couple to a voltage-dependent potassium current in N18TG2 x mesencephalon hybrid cell (MES-23.5) via distinct G proteins.
D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathway.
D3 dopamine receptor signals to activation of phospholipase D through a complex with Rho.
D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells.
Datura stramonium agglutinin released histamine from rat peritoneal mast cells that was inhibited by pertussis toxin, haptenic sugar and N-acetylglucosamine-specific lectins: involvement of glycoproteins with N-acetylglucosamine residues.
DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons.
Deaminovasopressin has direct and modulatory effects on ventricular automaticity in the rat heart.
Deciphering the role of Gi2 in opioid-induced adenylyl cyclase supersensitization.
Decline of IgG pertussis toxin measured in umbilical cord blood, and neonatal and early infant serum.
Decline of serologic immunity to diphtheria, tetanus and pertussis with age suggested a full life vaccination in mainland China.
Decrease in [Ca2+]c but not in cAMP Mediates L-AP4 inhibition of glutamate release: PKC-mediated suppression of this inhibitory pathway.
Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP.
Decreased insulin content and secretion in RIN 1046-38 cells overexpressing alpha 2-adrenergic receptors.
Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts.
Decreased potency of glucagon on transformed-induced MDCK cells does not reflect an alteration of adenylate cyclase components.
Deduced amino acid sequence of bovine retinal Go alpha: similarities to other guanine nucleotide-binding proteins.
Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness.
Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice.
Defective myogenesis in NFB-s mutant associated with a saturable suppression of MYF5 activity.
Defective regulation of phosphatidylcholine-specific phospholipases C and D in a kindred with Tangier disease. Evidence for the involvement of phosphatidylcholine breakdown in HDL-mediated cholesterol efflux mechanisms.
Defibrotide augments the anticandidial activity of NK cells.
Degranulation and cytokine expression in human cord blood-derived mast cells cultured in serum-free medium with recombinant human stem cell factor.
Dehydroepiandrosterone inhibits intracellular calcium release in beta-cells by a plasma membrane-dependent mechanism.
Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression.
Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through extracellular signal-regulated kinase 1/2-mediated mechanisms.
Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor.
Delayed cardioprotection is mediated via a non-peptide delta opioid agonist, SNC-121, independent of opioid receptor stimulation.
Delayed role of tumor necrosis factor- alpha in overcoming the effects of pertussis toxin.
Delayed-type hypersensitivity responses in mice treated with pertussis toxin and betamethasone.
Deletion analysis of the m4 muscarinic acetylcholine receptor. Molecular determinants for activation of but not coupling to the Gi guanine-nucleotide-binding regulatory protein regulate receptor internalization.
Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes.
Delineation of muscarinic receptor domains conferring selectivity of coupling to guanine nucleotide-binding proteins and second messengers.
Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta a H-2b mice.
Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment.
Delta opiate receptors account for the castration-induced unmasking of gonadotropin-releasing hormone binding sites in the rat pituitary.
Delta opioid modulation of the binding of guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: characterization of agonist and inverse agonist effects.
Delta opioid receptor down-regulation is independent of functional G protein yet is dependent on agonist efficacy.
Delta opioid receptors expressed by stably transfected jurkat cells signal through the map kinase pathway in a ras-independent manner.
Delta(9)-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling.
delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1.
delta- and mu-opioid receptor mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells.
Delta-opioid agonist-stimulated inositol phosphate formation in isolated, rabbit iris-ciliary bodies: role of G(i/o) proteins and Gbetagamma-subunits.
delta-Opioid receptor activates cAMP phosphodiesterase activities in neuroblastoma x glioma NG108-15 hybrid cells.
delta-Opioid receptor-stimulated Akt signaling in neuroblastomaxglioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation.
Delta-opioid receptors on astroglial cells in primary culture: mobilization of intracellular free calcium via a pertussis sensitive G protein.
delta-Opioids stimulate inositol 1,4,5-trisphosphate formation, and so mobilize Ca2+ from intracellular stores, in undifferentiated NG108-15 cells.
Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism.
Delta9-tetrahydrocannabinol stimulates glucose utilization in C6 glioma cells.
Demonstration of both A1 and A2 adenosine receptors in DDT1 MF-2 smooth muscle cells.
Demonstration of functional M3-muscarinic receptors in ventricular cardiomyocytes of adult rats.
Demonstration of GTP-binding proteins and ADP-ribosylated proteins in rat liver Golgi fraction.
Demonstration of mast cell chemotactic activity in bronchoalveolar lavage fluid collected from asthmatic patients before and during pollen season.
Demonstration of mast cell chemotactic activity in synovial fluid from rheumatoid patients.
Demonstration of the presence of G-proteins in hepatic microsomal fraction.
Dendritic cells distinguish individual chemokine signals through CCR7 and CXCR4.
Dependence and cross-dependence in the guinea-pig myenteric plexus.
Dependence of prolactin release on coupling between Ca(2+) mobilization and voltage-gated Ca(2+) influx pathways in rat lactotrophs.
Depolarization and activation of dihydropyridine-sensitive Ca2+ channels stimulate inositol phosphate accumulation in photoreceptor-enriched chick retinal cell cultures.
Depolarization-induced calcium channel facilitation in rod photoreceptors is independent of G proteins and phosphorylation.
Depolarization-induced suppression of GABAergic inhibition in rat hippocampal pyramidal cells: G protein involvement in a presynaptic mechanism.
Depression of cardiac L-type calcium current by a scorpion venom fraction M1 following muscarinic receptors interaction involving adenylate cyclase pathway.
Depression of excitability by sphingosine 1-phosphate in rat ventricular myocytes.
Depression of liver metabolism and induction of cytokine release by diphtheria and tetanus toxoids and pertussis vaccines: role of Bordetella pertussis cells in toxicity.
Deregulation of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor in murine macrophage cell line J774A.1.
Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.
Dermonecrotic toxin and tracheal cytotoxin, putative virulence factors of Bordetella avium.
Description and evaluation of serologic assays used in a multicenter trial of acellular pertussis vaccines.
Description of a hybridoma bank towards Bordetella pertussis toxin and surface antigens.
Desensitization and functional antagonism by beta-adrenoceptor and muscarinic receptor agonists, respectively: a comparison with receptor alkylation for calculation of apparent agonist affinity.
Desensitization and resensitization of beta 1- and putative beta 4-adrenoceptor mediated responses occur in parallel in a rat model of cardiac failure.
Desensitization in rat parotid to beta-adrenergic agonists and counteracting effects of forskolin are conserved in membrane and detergent-solubilized adenylate cyclase catalyst activity.
Desensitization of cardiac beta-adrenoceptor signaling with heart failure produced by myocardial infarction in the rat. Evidence for the role of Gi but not Gs or phosphorylating proteins.
Desensitization of somatostatin-induced inhibition of low extracellular magnesium concentration-induced calcium spikes in cultured rat hippocampal neurons.
Desensitization of the canine A2a adenosine receptor: delineation of multiple processes.
Desensitization of the epidermal adenylate cyclase system: agonists and phorbol esters desensitize by independent mechanisms.
Desensitization of vasopressin sensitive adenylate cyclase by vasopressin and phorbol esters.
Desensitization to parathyroid hormone in renal cells from aged rats is associated with alterations in G-protein activity.
Designing a new multi-epitope pertussis vaccine with highly population coverage based on a novel sequence and structural filtration algorithm.
Detection and quantitation of heterotrimeric G proteins by fluorescence resonance energy transfer.
Detection and subcellular localization of three Ptl proteins involved in the secretion of pertussis toxin from Bordetella pertussis.
Detection of anti-pertussis toxin IgG in oral fluids for use in diagnosis and surveillance of Bordetella pertussis infection in children and young adults.
Detection of antibodies against fimbria type 3 (Fim3) is useful diagnostic assay for pertussis.
Detection of antibodies inhibiting the ADP-ribosyltransferase activity of pertussis toxin in human serum.
Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase.
Detection of Bordetella pertussis from Clinical Samples by Culture and End-Point PCR in Malaysian Patients.
Detection of Bordetella pertussis using a PCR test in infants younger than one year old hospitalized with whooping cough in five Peruvian hospitals.
Detection of G proteins in purified bovine brain myelin.
Detection of residual pertussis toxin in vaccines using a modified ribosylation assay.
Detection of subunits of pertussis toxin in Tn5-induced Bordetella mutants deficient in toxin biological activity.
Detection of the major pertussis toxin substrate of human leukocytes with antisera raised against synthetic peptides.
Determinants of alpha 2-adrenergic receptor activation of G proteins: evidence for a precoupled receptor/G protein state.
Determinants of natriuretic peptide gene expression.
Determinants of the G protein-dependent opioid modulation of neuronal calcium channels.
Determinants Present in the Receptor Carboxy Tail Are Responsible for Differences in Subtype-Specific Coupling of beta-Adrenergic Receptors to Phosphoinositide 3-Kinase.
Determination of antibodies to pertussis toxin in working reference preparations of anti-pertussis sera from various national control laboratories.
Determination of circulating antibodies directed to pertussis toxin and of agglutinogens in children vaccinated with either the whole cell or component pertussis vaccine in France, Japan and Senegal.
Determination of pertactin IgG antibodies for the diagnosis of pertussis.
Determination of serum neutralizing antibodies reveals important difference in quality of antibodies against pertussis toxin in children after infection.
Determination of T cell epitopes on the S1 subunit of pertussis toxin.
Determination of [35S]guanosine-5'-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay.
Detoxification of Bordetella pertussis organisms or pertussis toxin with glutaraldehyde for preparation of pertussis vaccine.
Detoxification of pertussis toxin by site-directed mutagenesis.
Detoxification of pertussis toxin by site-directed mutagenesis: a review of connaught strategy to develop a recombinant pertussis vaccine.
Development and Characterization of an Allergic Asthma Rat Model for Interventional Studies.
Development and clinical testing of an acellular pertussis vaccine containing genetically detoxified pertussis toxin.
Development and evaluation of dual-target real-time polymerase chain reaction assays to detect Bordetella spp.
Development and implementation of standardized method for detecting immunogenicity of acellular pertussis vaccines in Korea.
Development and migration of plasma cells in the mouse lymph node.
Development and use of a receptor antibody to characterize the interaction between somatostatin receptor subtype 1 and G proteins.
Development and validation of a multiplex immunoassay for the simultaneous determination of serum antibodies to Bordetella pertussis, diphtheria and tetanus.
Development and validation of a robust multiplex serological assay to quantify antibodies specific to pertussis antigens.
Development and Validation of Magnetic Bead Pentaplex Immunoassay for Simultaneous Quantification of murine serum IgG antibodies to Acellular Pertussis, Diphtheria and Tetanus Antigens used in combination vaccines.
Development of a carbohydrate binding assay for the B-oligomer of pertussis toxin and toxoid.
Development of a homogeneous MAP kinase reporter gene screen for the identification of agonists and antagonists at the CXCR1 chemokine receptor.
Development of a qualitative assay for screening of Bordetella pertussis isolates for pertussis toxin production.
Development of a rapid diagnostic test for pertussis: direct detection of pertussis toxin in respiratory secretions.
Development of a selective agonist at the somatostatin receptor subtype sstr1.
Development of acellular pertussis vaccines.
Development of an improved animal model of experimental autoimmune myositis.
Development of G protein-mediated Ca2+ channel regulation in mouse embryonic stem cell-derived neurons.
Development of muscarinic analgesics derived from epibatidine: role of the M4 receptor subtype.
Development of muscarinic-cholinergic stimulation of inositol phosphate production in cultured embryonic chick atrial cells. Evidence for a switch in guanine-nucleotide-binding protein coupling.
Development of neutralising human recombinant antibodies to pertussis toxin.
Development of safer pertussis DNA vaccine expressing non-toxic C180 polypeptide of pertussis toxin S1 subunit.
Development of the inhibitory guanine nucleotide-binding regulatory protein in the rat testis.
Developmental changes in adenylyl cyclase and GTP binding proteins in brown fat.
Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains.
Developmental changes in guanine nucleotide regulatory proteins in the rat myocardial alpha 1-adrenergic receptor complex.
Developmental changes in the levels of substrates for cholera toxin-catalyzed and pertussis toxin-catalyzed ADP-ribosylation in rat cardiac cell membranes.
Developmental changes in the muscarinic stimulation of canine Purkinje fibers.
Developments in reduction and replacement of in vivo toxicity and potency tests for pertussis vaccines.
Dexamethasone effects on beta-adrenergic receptors and adenylate cyclase regulatory proteins Gs and Gi in ROS 17/2.8 cells.
Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat.
Dexmedetomidine Inhibits ASIC Activity via Activation of ?2A Adrenergic Receptors in Rat Dorsal Root Ganglion Neurons.
Dexmedetomidine injection into the locus ceruleus produces antinociception.
Dexras1 inhibits adenylyl cyclase.
dgq: a drosophila gene encoding a visual system-specific G alpha molecule.
Diabetes decreases sensitivity of adipocyte lipolysis to inhibition by Gi-linked receptor agonists.
Diacylglycerol and ceramide formation induced by dopamine D2S receptors via Gbeta gamma -subunits in Balb/c-3T3 cells.
Diacylglycerol mass measurements in stimulated HL-60 phagocytes.
Diacylglycerol production induced by growth hormone in Ob1771 preadipocytes arises from phosphatidylcholine breakdown.
Diadenosine polyphosphates induce intracellular Ca2+ mobilization in human neutrophils via a pertussis toxin sensitive G-protein.
Diagnostic evaluation of polymerase chain reaction discriminative for Bordetella pertussis, B. parapertussis, and B. bronchiseptica.
Diagnostic performance of commercial serological assays measuring Bordetella pertussis IgG antibodies.
Dibutyryl Cyclic AMP Inhibits the Progression of Experimental Autoimmune Encephalomyelitis and Potentiates Recruitment of Endogenous Neural Stem Cells.
Dibutyryl cyclic AMP-induced morphological differentiation of rat brain astrocytes increases alpha 1-adrenoceptor induced phosphoinositide breakdown by a mechanism involving protein synthesis.
Dichotomous effects of beta-chemokines on HIV replication in monocytes and monocyte-derived macrophages.
Dieldrin induces human neutrophil superoxide production via protein kinases C and tyrosine kinases.
Dietary fish oil deactivates a growth-promoting signaling pathway in hepatoma 7288CTC in Buffalo rats.
Difference in effects of sodium fluoride and cholecystokinin on diacylglycerol accumulation and calcium increase in guinea pig gastric chief cells.
Differences between presynaptic and postsynaptic GABAB mechanisms in rat hippocampal pyramidal cells.
Differences in agonist-independent and -dependent 5-hydroxytryptamine2C receptor-mediated cell division.
Differences in antibody response to whole-cell pertussis vaccines.
Differences in avidity of IgG antibodies to pertussis toxin after acellular pertussis booster vaccination and natural infection.
Differences in coughing and other responses to intrabronchial infection with Bordetella pertussis among strains of rats.
Differences in CXCR4-mediated signaling in B cells.
Differences in efficacy and Na(+) sensitivity between alpha(2B) and alpha(2D) adrenergic receptors: implications for R and R* states.
Differences in epitope-specific antibodies to pertussis toxin after infection and acellular vaccinations.
Differences in platelet-activating factor receptor mediated Ca++ response between hamster and guinea pig alveolar macrophages.
Differences in signal transduction between Fc gamma receptors (Fc gamma RII, Fc gamma RIII) and FMLP receptors in neutrophils. Effects of colchicine on pertussis toxin sensitivity and diacylglycerol formation.
Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins.
Differences in the actions of calcium versus lanthanum to influence parathyroid hormone release.
Differences in the genomic content of Bordetella pertussis isolates before and after introduction of pertussis vaccines in four European countries.
Differences in the operational characteristics of the human recombinant somatostatin receptor types, sst1 and sst2, in mouse fibroblast (Ltk-) cells.
Differences in the regulation of fibroblast contraction of floating versus stressed collagen matrices.
Differences of humoral and cellular immune response to an acellular pertussis booster in adolescents with a whole cell or acellular primary vaccination.
Different abilities of two types of Fc gamma receptor on guinea-pig macrophages to trigger the phosphatidylinositol turnover.
Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries.
Different alpha1-adrenoceptor-induced inositol phosphate formation in the two portions of rat vas deferens.
Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells.
Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation.
Different effects of phorbol ester on angiotensin II- and stable GTP analogue-induced activation of polyphosphoinositide phosphodiesterase in membranes isolated from rat renal mesangial cells.
Different effects of the different natural CC chemokine receptor 2b ligands on beta-arrestin recruitment, G?i signaling, and receptor internalization.
Different endothelin receptor subtypes are involved in phospholipid signalling in the proximal tubule of rat kidney.
Different G proteins are involved in the biphasic response of clonal rat pituitary cells to thyrotropin-releasing hormone.
Different G proteins mediate somatostatin-induced inward rectifier K+ currents in murine brain and endocrine cells.
Different G proteins mediate the opioid inhibition or enhancement of evoked [5-methionine]enkephalin release.
Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils.
Different GTP-binding proteins mediate regulation of calcium channels by acetylcholine and noradrenaline in rat sympathetic neurons.
Different guanosine triphosphate-binding proteins couple vasopressin receptor to phospholipase C and phospholipase A2 in glomerular mesangial cells.
Different IgG-subclass distributions after whole-cell and acellular pertussis infant primary vaccinations in healthy and pertussis infected children.
Different mechanisms are involved in intracellular calcium increase by insulin-like growth factors 1 and 2 in articular chondrocytes: voltage-gated calcium channels, and/or phospholipase C coupled to a pertussis-sensitive G-protein.
Different pathways for activation of extracellular signal-regulated kinase through thromboxane A2 receptor isoforms.
Different patterns of Ca(2+) signals are induced by low compared to high concentrations of P2Y agonists in microglia.
Different proliferative responses of Gi/o-protein-coupled receptors in human myometrial smooth muscle cells. A possible role of calcium.
Different regulation of ERK1/2 activation by beta-adrenergic receptor subtypes in adult mouse cardiomyocytes.
Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)).
Different sensitivities of the responses of human neutrophils stimulated with immune complex and C5a anaphylatoxin to pertussis toxin.
Different sensitivity to phorbol esters and pertussis toxin of bombesin- and platelet-derived growth factor-induced, phospholipase C-mediated hydrolysis of phosphoinositides in NIH/3T3 cells.
Different signal transduction pathways are coupled to the nucleotide receptor and the P2Y receptor in C6 glioma cells.
Different sites of action of arachidonic acid on steroidogenesis in rat Leydig cells.
Different stimulatory opioid effects on intracellular Ca(2+) in SH-SY5Y cells.
Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination.
Different tachykinin receptor subtypes are coupled to the phosphoinositide or cyclic AMP signal transduction pathways in rat submandibular cells.
Different types of ADP-ribose protein bonds formed by botulinum C2 toxin, botulinum ADP-ribosyltransferase C3 and pertussis toxin.
Different types of glutamate receptors in isolated and identified neurones of the mollusc Planorbarius corneus.
Differential action of somatostatin on peptide-induced release of acetylcholine.
Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants.
Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL.
Differential activation of Gq/11 and Gi(3) proteins at 5-hydroxytryptamine(2C) receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking.
Differential activation of signal transduction pathways mediating oxidative burst by chicken heterophils in response to stimulation with lipopolysaccharide and lipoteichoic acid.
Differential activation of signal transduction pathways mediating phagocytosis, oxidative burst, and degranulation by chicken heterophils in response to stimulation with opsonized Salmonella enteritidis.
Differential activation of the stimulatory and inhibitory guanine nucleotide-binding proteins by fluoroaluminate in cells and in membranes.
Differential agonist activity of somatostatin and L-362855 at human recombinant sst4 receptors.
Differential agonist regulation of the human kappa-opioid receptor.
Differential alterations in cardiac adrenergic signaling in chronic hypoxia or norepinephrine infusion.
Differential alterations in left and right ventricular G-proteins in congestive heart failure due to myocardial infarction.
Differential binding of BvgA to two classes of virulence genes of Bordetella pertussis directs promoter selectivity by RNA polymerase.
Differential calcium regulation of proinflammatory activities in human neutrophils exposed to the neuropeptide pituitary adenylate cyclase-activating protein.
Differential calcium signalling by m2 and m3 muscarinic acetylcholine receptors in a single cell type.
Differential cardiotoxic/cardioprotective effects of beta-adrenergic receptor subtypes in myocytes and fibroblasts in doxorubicin cardiomyopathy.
Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and ?-conotoxin Vc1.1 via GABAB receptor activation.
Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells.
Differential cholera-toxin sensitivity of supraspinal antinociception induced by the cannabinoid agonists delta9-THC, WIN 55,212-2 and anandamide in mice.
Differential cholera-toxin- and pertussis-toxin-catalysed ADP-ribosylation of G-proteins coupled to formyl-peptide and leukotriene B4 receptors.
Differential coupling of 5-HT(1) receptors to G proteins of the G(i) family.
Differential coupling of D1 and D5 dopamine receptors to guanine nucleotide binding proteins in transfected GH4C1 rat somatomammotrophic cells.
Differential coupling of dopaminergic D2 receptors expressed in different cell types. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in LtK- fibroblasts, hyperpolarization, and cytosolic-free Ca2+ concentration decrease in GH4C1 cells.
Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes.
Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-trisphosphate and adenosine 3',5'-cyclic monophosphate accumulation in Chinese hamster ovary cells.
Differential coupling of mu-competitive and mu-noncompetitive delta opiate receptors to guanine nucleotide binding proteins in rat brain membranes.
Differential coupling of muscarinic m2 and m3 receptors to adenylyl cyclases V/VI in smooth muscle. Concurrent M2-mediated inhibition via Galphai3 and m3-mediated stimulation via Gbetagammaq.
Differential coupling of muscarinic receptors to Ca2+ mobilization and cyclic AMP in SH-SY5Y and IMR 32 neuroblastoma cells.
Differential coupling of the formyl peptide receptor to adenylate cyclase and phospholipase C by the pertussis toxin-insensitive Gz protein.
Differential coupling with pertussis toxin-sensitive G proteins of dopamine and somatostatin receptors involved in regulation of adenohypophyseal secretion.
Differential detection of B. pertussis from B. parapertussis using a polymerase chain reaction (PCR) in presence of SYBR green1 and amplicon melting analysis.
Differential effect of adenosine on rhabdomyosarcoma migration and proliferation.
Differential effect of Bordetella pertussis on experimental posterior uveitis in the black-hooded Lister rat.
Differential effect of high extracellular Ca2+ on K+ and Cl- conductances in murine osteoclasts.
Differential effect of pertussis toxin on adenosine and muscarinic inhibition of cyclic AMP accumulation in canine ventricular myocytes.
Differential effect of pertussis toxin on pre- and postjunctional alpha 2-adrenoceptors in the cardiovascular system of the pithed rat.
Differential effect of pertussis toxin on the affinity state for agonists of renal alpha 1- and alpha 2- adrenoceptors.
Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells. Gi2- and Gbeta/gamma-dependent signaling pathways.
Differential effects of bacterial toxins on mitogenic actions of sodium fluoride and those of aluminum fluoride in human TE85 osteosarcoma cells.
Differential effects of cholera toxin and pertussis toxin on the c-fos and c-jun mRNA expression in rat C6 glioma cells.
Differential effects of cytokines on long-term mitogenic and secretory responses of fetal rat pancreatic beta-cells.
Differential effects of endothelin-1 on basal and isoprenaline-enhanced Ca2+ current in guinea-pig ventricular myocytes.
Differential effects of fluoride and a non-hydrolysable GTP analogue on adenylate cyclase and G-proteins in Ceratitis capitata neural tissue.
Differential effects of G protein coupled receptors on hematopoietic progenitor cell growth depend on their signaling capacities.
Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells.
Differential effects of lovastatin on mitogen induced calcium influx in human cultured vascular smooth muscle cells.
Differential effects of pertussis toxin and lithium on muscarinic responses in the atria and ileum: evidence for receptor heterogeneity.
Differential effects of pertussis toxin on body temperature changes induced by neuropeptide Y and NPY2-36.
Differential effects of pertussis toxin on insulin-stimulated phosphatidylcholine hydrolysis and glycerolipid synthesis de novo. Studies in BC3H-1 myocytes and rat adipocytes.
Differential effects of pertussis toxin on muscarinic responses in isolated atria and smooth muscle.
Differential effects of pertussis toxin on the muscarinic regulation of Ca2+ and K+ currents in frog cardiac myocytes.
Differential Effects of the G?5-RGS7 Complex on Muscarinic M3 Receptor-Induced Ca2+ Influx and Release.
Differential expression of Ia by murine keratinocytes and gut epithelium in response to recombinant gamma-interferon.
Differential expression of MCP-1 and its receptor CCR2 in glucose primed human mesangial cells.
Differential functional effects of two 5-HT4 receptor isoforms in adult cardiomyocytes.
Differential G protein-mediated coupling of D2 dopamine receptors to K+ and Ca2+ currents in rat anterior pituitary cells.
Differential G protein-mediated coupling of neurotransmitter receptors to Ca2+ channels in rat dorsal root ganglion neurons in vitro.
Differential IL-10 production by DCs determines the distinct adjuvant effects of LPS and PTX in EAE induction.
Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid.
Differential interaction of beta 1- and beta 3-adrenergic receptors with Gi in rat adipocytes.
Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes.
Differential involvement of Galpha16 in CC chemokine-induced stimulation of phospholipase Cbeta, ERK, and chemotaxis.
Differential involvement of hippocampal G-protein subtypes in the memory process of rats.
Differential ion current activation by human 5-HT(1A) receptors in Xenopus oocytes: evidence for agonist-directed trafficking of receptor signalling.
Differential isoprenylation of carboxy-terminal mutants of an inhibitory G-protein alpha-subunit: neither farnesylation nor geranylgeranylation is sufficient for membrane attachment.
Differential localization of the mRNAs for the pertussis toxin insensitive G-protein alpha sub-units Gq, G11, and Gz in the rat brain, and regulation of their expression after striatal deafferentation.
Differential mechanisms of dopamine and somatostatin inhibition of prolactin secretion from anterior pituitary cells.
Differential modulation of ATP-induced calcium signalling by A1 and A2 adenosine receptors in cultured cortical astrocytes.
Differential modulation of rod and cone calcium currents in tiger salamander retina by D2 dopamine receptors and cAMP.
Differential modulatory effects of cholera toxin and pertussis toxin on pain behavior induced by TNF-alpha, interleukin-1beta and interferon-gamma injected intrathecally.
Differential modulatory roles of cholera toxin and pertussis toxin in the regulation of pain responses induced by excitatory amino acids administered intrathecally in mice.
Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes.
Differential osmosensing signalling pathways and G-protein involvement in human cervical cells with different tumour potential.
Differential phospholipase D activation by bradykinin and sphingosine 1-phosphate in NIH 3T3 fibroblasts overexpressing gelsolin.
Differential potentiation of arachidonic acid release by rat alpha2 adrenergic receptor subtypes.
Differential prevention of morphine amnesia by antisense oligodeoxynucleotides directed against various Gi-protein alpha subunits.
Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: II. Effect of pertussis and cholera toxins.
Differential purification of autocrine motility factor derived from a murine protein-free fibrosarcoma.
Differential regulation by cAMP-dependent protein kinase and protein kinase C of the mu opioid receptor coupling to a G protein-activated K+ channel.
Differential regulation of 46 and 54 kDa jun N-terminal kinases and p38 mitogen-activated protein kinase by human alpha(1A)-adrenoceptors expressed in Rat-1 cells.
Differential regulation of accessory mitogenic signaling receptors by the T cell antigen receptor.
Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates.
Differential regulation of beta 1 and beta 2 integrin avidity by chemoattractants in eosinophils.
Differential regulation of Bordetella pertussis virulence factors.
Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling.
Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced ?-opioid receptors.
Differential regulation of cyclic AMP synthesis by estrogen in MCF7 cells.
Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells.
Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins.
Differential regulation of extracellular signal-regulated protein kinase 1 and Jun N-terminal kinase 1 by Ca2+ and protein kinase C in endothelin-stimulated Rat-1 cells.
Differential regulation of formyl peptide and platelet-activating factor receptors. Role of phospholipase Cbeta3 phosphorylation by protein kinase A.
Differential regulation of G protein subunit expression in mouse oocytes, eggs, and early embryos.
Differential regulation of G protein-gated inwardly rectifying K(+) channel kinetics by distinct domains of RGS8.
Differential regulation of glutamate decarboxylase and preproenkephalin mRNA levels in the rat striatum.
Differential regulation of inositol 1,4,5-trisphosphate by co-existing P2Y-purinoceptors and nucleotide receptors on bovine aortic endothelial cells.
Differential regulation of Na+ and Cl- conductances by PTX-sensitive G proteins in fetal lung apical membrane vesicles.
Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts.
Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity.
Differential regulation of thrombin- or ATP-induced mobilization of intracellular Ca2+ by prostacyclin receptor in mouse mastocytoma cells.
Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation.
Differential response of cortical plate and ventricular zone cells to GABA as a migration stimulus.
Differential response of mast cells separated from various organs and basophils of dogs to the fluoroquinolone antimicrobial levofloxacin.
Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals.
Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells.
Differential roles of Fas ligand in spontaneous and actively induced autoimmune encephalomyelitis.
Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell proliferation and motility by thrombospondin 1.
Differential roles of spinal cholera toxin- and pertussis toxin-sensitive G proteins in nociceptive responses caused by formalin, capsaicin, and substance P in mice.
Differential routes of Ca2+ influx in Swiss 3T3 fibroblasts in response to receptor stimulation.
Differential sensitivity of 5-HT1B auto and heteroreceptors.
Differential sensitivity of alpha o and alpha i to ADP-ribosylation by pertussis toxin in the intact cultured embryonic chick ventricular myocyte. Relationship to the role of G proteins in the coupling of muscarinic cholinergic receptors to inhibition of adenylate cyclase activity.
Differential sensitivity of arachidonic acid release and 1,2-diacylglycerol formation to pertussis toxin, GDP beta S and NaF in saponin-permeabilized human platelets: possible evidence for distinct GTP-binding proteins involving phospholipase C and A2 activation.
Differential sensitivity of phosphoinositide metabolism to sodium fluoride and carbachol treatments in PC12 cells.
Differential sensitivity of progesterone- and zona pellucida-induced acrosome reactions to pertussis toxin.
Differential sensitivity of the short and long human dopamine D2 receptor subtypes to protein kinase C.
Differential sensitivity to pertussis toxin of 3T3 cells transformed with different oncogenes.
Differential signaling pathways in platelet-activating factor-induced proliferation and interleukin-6 production by rat vascular smooth muscle cells.
Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway.
Differential Signalling by Splice Variants of the Human Free Fatty Acid Receptor, GPR120.
Differential signalling of the chemokine receptor CXCR4 by stromal cell-derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes.
Differential superactivation of adenylyl cyclase isozymes after chronic activation of the CB(1) cannabinoid receptor.
Differential Susceptibility of Guanine Nucleotide-binding Proteins to Pertussis Toxin-catalyzed ADP-ribosylation in Brain Membranes of Two Congeneric Marine Fishes.
Differential T- and B-Cell Responses to Pertussis in Acellular Vaccine-Primed versus Whole-Cell Vaccine-Primed Children 2 Years after Preschool Acellular Booster Vaccination.
Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor.
Differentially expressed genes in Bordetella pertussis strains belonging to a lineage which recently spread globally.
Differentiation of BA-HAN-1C rhabdomyosarcoma cells is controlled by a pertussis toxin sensitive signaling pathway.
Differentiation of muscarinic receptors mediating negative chronotropic and vasoconstrictor responses to acetylcholine in isolated rat hearts.
Differentiation of Neuro-2a neuroblastoma cells by an antibody to GM3 ganglioside.
Differentiation of renal Na(+)-K(+)-ATPase in control and streptozotocin-induced diabetic mice by G-protein acting toxins and phorbol esters.
Differentiation-linked activation of the respiratory burst in a monocytic cell line (U937) via Fc gamma RII. A study of activation pathways and their regulation.
DIgLONs inhibit initiation of neurite outgrowth from forebrain neurons via an IgLON-containing receptor complex.
Dihydropiridine inhibition of K+ and maitotoxin stimulated calcium fluxes in PC12 cells: effect of pertussis toxin.
Dihydropyridine modulation of voltage-activated calcium channels in PC12 cells: effect of pertussis toxin pretreatment.
Dihydropyridine receptors as voltage sensors for a depolarization-evoked, IP3R-mediated, slow calcium signal in skeletal muscle cells.
Dihydropyridine- and omega-conotoxin-sensitive Ca2+ currents in cerebellar neurons: persistent block of L-type channels by a pertussis toxin-sensitive G-protein.
Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.
Dimers of G-protein coupled receptors as versatile storage and response units.
Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes.
Diminished basal phosphorylation level of phospholamban in the postinfarction remodeled rat ventricle: role of beta-adrenergic pathway, G(i) protein, phosphodiesterase, and phosphatases.
Diminution of contractile response by kappa-opioid receptor agonists in isolated rat ventricular cardiomyocytes is mediated via a pertussis toxin-sensitive G protein.
Dinucleoside polyphosphates and their interaction with other nucleotide signaling pathways.
Dioleoyl phosphatidic acid increases intracellular Ca2+ through endogenous LPA receptors in C6 glioma and L2071 fibroblasts.
Dioleoyl phosphatidic acid induces morphological changes through an endogenous LPA receptor in C6 glioma cells.
Diphtheria, tetanus and pertussis antibodies in 10-year-old children before and after a booster dose of three toxoids: implications for the timing of a booster dose.
Diphtheria-tetanus-acellular pertussis vaccine adsorbed (Triacelluvax; DTaP3-CB): a review of its use in the prevention of Bordetella pertussis infection.
Direct action of pertussis toxin in isolated hamster fat cells.
Direct activation of GTP-binding proteins by venom peptides that contain cationic clusters within their alpha-helical structures.
Direct activation of second messenger pathways mimics cell adhesion molecule-dependent neurite outgrowth.
Direct and biochemical interaction between dopamine D3 receptor and elongation factor-1Bbetagamma.
Direct autocrine inhibition and cAMP-dependent potentiation of single L-type Ca2+ channels in bovine chromaffin cells.
Direct coupling of a G-protein to dihydropyridine binding sites.
Direct Coupling of a Seven-Transmembrane-Span Receptor to a G?i G-Protein Regulatory Motif Complex.
Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells.
Direct coupling of the somatostatin receptor to potassium channels by a G protein.
Direct dopamine D2-receptor-mediated modulation of arachidonic acid release in transfected CHO cells without the concomitant administration of a Ca2+-mobilizing agent.
Direct effect of adenosine on prolactin secretion at the level of the single rat lactotroph: involvement of pertussis toxin-sensitive and -insensitive transducing mechanisms.
Direct effects of wheat germ agglutinin on inositol phosphate formation and cytosolic-free calcium level in intestine 407 cells.
Direct evidence for functional coupling of the vasoactive intestinal peptide receptor to Gi3 in native lung membranes.
Direct evidence for involvement of a guanine nucleotide-binding protein in chemotactic peptide-stimulated formation of inositol bisphosphate and trisphosphate in differentiated human leukemic (HL-60) cells. Reconstitution with Gi or Go of the plasma membranes ADP-ribosylated by pertussis toxin.
Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells.
Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets.
Direct inhibition of voltage-dependent Ca(2+) fluxes by ethanol and higher alcohols in rabbit T-tubule membranes.
Direct inhibitory effects of a somatostatin analog, SMS 201-995, on AR4-2J cell proliferation via pertussis toxin-sensitive guanosine triphosphate-binding protein-independent mechanism.
Direct modulation by androgens of the response of human bone cells (SaOS-2) to human parathyroid hormone (PTH) and PTH-related protein.
Direct modulation of voltage-dependent calcium channels by muscarinic activation of a pertussis toxin-sensitive G-protein in hippocampal neurons.
Direct molecular typing of Bordetella pertussis from clinical specimens submitted for diagnostic quantitative (real-time) PCR.
Direct neuropeptide Y-induced modulation of gonadotrope intracellular calcium transients and gonadotropin secretion.
Direct regulation of vascular smooth muscle contraction by mastoparan-7.
Direct relationship between intracellular calcium mobilization and phospholipase D activation in prostaglandin E-stimulated human erythroleukemia cells.
Direct role of plasma membrane-expressed gp120/41 in toxicity to human astrocytes induced by HIV-1-infected macrophages.
Direct stimulation of adenylate cyclase by mechanical forces in S49 mouse lymphoma cells during hyposmotic swelling.
Directed shift of fatty acids from phospholipids to triacylglycerols in HL-60 cells induced by nanomolar concentrations of triethyl lead chloride: involvement of a pertussis toxin-sensitive pathway.
Discovery of Compounds Inhibiting the ADP-Ribosyltransferase Activity of Pertussis Toxin.
Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine.
Disodium cromoglycate inhibits production of immunoglobulin E.
Disparate effects of interferon-gamma and tumor necrosis factor-alpha on early neutrophil respiratory burst and fungicidal responses to Candida albicans hyphae in vitro.
Disparate effects of neuropeptide Y and clonidine on the excretion of sodium and water in the rat.
Disparity in Fc?RI-Induced Degranulation of Primary Human Lung and Skin Mast Cells Exposed to Adenosine.
Dispensable role of chemokine receptors in migration of mycobacterial antigen-specific CD4+ T cells into Mycobacterium-infected lung.
Disruption of G(i/o) protein signaling in the nucleus accumbens results in a D1 dopamine receptor-mediated hyperactivity.
Disruption of inhibitory G-proteins mediates a reduction in atrial beta-adrenergic signaling by enhancing eNOS expression.
Dissecting human T cell responses against Bordetella species.
Dissection of lymphocyte function-associated antigen 1-dependent adhesion and signal transduction in human natural killer cells shown by the use of cholera or pertussis toxin.
Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.
Dissemination of lymphocytic choriomeningitis virus from the gastric mucosa requires G protein-coupled signaling.
Dissociating the enhancing and inhibitory effects of pertussis toxin on autoimmune disease.
Dissociation between muscarinic receptor-mediated inhibition of adenylate cyclase and autoreceptor inhibition of [3H] acetylcholine release in rat hippocampus.
Dissociation of antiproliferative and antihormonal effects of the somatostatin analog octreotide on 7315b pituitary tumor cells.
Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2.
Dissociation of mitogen-activated protein kinase activation from p125 focal adhesion kinase tyrosine phosphorylation in Swiss 3T3 cells stimulated by bombesin, lysophosphatidic acid, and platelet-derived growth factor.
Dissociation of opioid receptor upregulation and functional supersensitivity.
Dissociation of second messenger activation by parathyroid hormone fragments in osteosarcoma cells.
Distinct Ca2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR1 and PAR4) in vascular endothelial cells.
Distinct cellular expression of pertussis toxin-sensitive GTP-binding proteins in rat cerebellum.
Distinct components of morphine effects on cardiac myocytes are mediated by the kappa and delta opioid receptors.
Distinct guanine nucleotide binding and release properties of the three Gi proteins.
Distinct kinetic and spatial patterns of PKC- and EGFR-dependent activation of extracellular signal-regulated kinases 1 and 2 by humane nicotinic acid receptor GPR109A.
Distinct mechanisms for Ca2+ entry induced by OKT3 and Ca2+ depletion in Jurkat T cells.
Distinct mode of G protein activation due to single residue substitution of active IGF-II receptor peptide Arg2410-Lys2423: evidence for stimulation acceptor region other than C-terminus of Gi alpha.
Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells.
Distinct muscarinic receptor subtypes suppress excitatory and inhibitory synaptic responses in cortical neurons.
Distinct muscarinic receptors enhance spontaneous GABA release and inhibit electrically evoked GABAergic synaptic transmission in the chick lateral spiriform nucleus.
Distinct muscarinic receptors, G proteins and phospholipases in esophageal and lower esophageal sphincter circular muscle.
Distinct pathways for beta-adrenoceptor-induced up-regulation of muscarinic acetylcholine receptors and inhibitory G-protein alpha-subunits in chicken cardiomyocytes.
Distinct Pathways of ERK1/2 Activation by Hydroxy-Carboxylic Acid Receptor-1.
Distinct pathways regulate transforming growth factor beta 1-stimulated proto-oncogene and extracellular matrix gene expression.
Distinct Physiological Effects of ?1- and ?2-Adrenoceptors in Mouse Ventricular Myocytes: Insights from a Compartmentalized Mathematical Model.
Distinct receptors and different transduction mechanisms for ATP and adenosine at the frog motor nerve endings.
Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins.
Distinct roles for Galpha(i)2 and Gbetagamma in signaling to DNA synthesis and Galpha(i)3 in cellular transformation by dopamine D2S receptor activation in BALB/c 3T3 cells.
Distinct roles for Galphai2, Galphai3, and Gbeta gamma in modulation offorskolin- or Gs-mediated cAMP accumulation and calcium mobilization by dopamine D2S receptors.
Distinct roles of Ca2+ mobilization and G protein usage on regulation of Toll-like receptor function in human and murine mast cells.
Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production.
Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes.
Distinct signalling pathways of murine histamine H1- and H4-receptors expressed at comparable levels in HEK293 cells.
Distinct tyrosine kinase activation and Triton X-100 insolubility upon Fc gamma RII or Fc gamma RIIIB ligation in human polymorphonuclear leukocytes. Implications for immune complex activation of the respiratory burst.
Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA.
Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2.
Distribution and pharmacological characterization of muscarinic-cholinergic receptors in the cockroach brain.
Distribution and role of heterotrimeric G proteins in the secretory pathway of polarized epithelial cells.
Distribution of pertussis antibodies among different age groups in Japan.
Distribution of the alpha-subunit of the guanine nucleotide-binding protein Gi2 and its comparison to G alpha o.
Disulfanyl peptide decreases melanin synthesis via receptor-mediated ERK activation and the subsequent downregulation of MITF and tyrosinase.
Diuretic and renal protective effects of 8-(noradamantan-3-yl)-1,3-dipropylxanthine (KW-3902), a novel adenosine A1-receptor antagonist, via pertussis toxin insensitive mechanism.
Diuretic response to adenosine A(1) receptor blockade in normotensive and spontaneously hypertensive rats: role of pertussis toxin-sensitive G-proteins.
Divalent cations suppress 3',5'-adenosine monophosphate accumulation by stimulating a pertussis toxin-sensitive guanine nucleotide-binding protein in cultured bovine parathyroid cells.
Divergent regulation of beta 2-adrenoceptors and adenylate cyclase in the Cyc- mouse T lymphoma cell line TL2-9.
Divergent stimulatory and inhibitory actions of carbamoylcholine on gastric D-cells.
Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity.
Diverse chemotactic responses of Dictyostelium discoideum amoebae in the developing (temporal) and stationary (spatial) concentration gradients of folic acid, cAMP, Ca(2+) and Mg(2+).
Diverse functions of muscarinic acetylcholine receptor subtypes.
Diverse prostaglandin receptors activate distinct signal transduction pathways in rat myometrium.
Diverse signal transduction pathways mediated by endogenous P2 receptors in cultured rat cerebral cortical neurons.
Diversified serum IgG response involving non-myelin CNS proteins during experimental autoimmune encephalomyelitis.
DNA binding of the Bordetella pertussis H1 homolog alters in vitro DNA flexibility.
DNA microarray analysis reveals a role for lysophosphatidic acid in the regulation of anti-inflammatory genes in MC3T3-E1 cells.
DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3.
DNA topology affects transcriptional regulation of the pertussis toxin gene of Bordetella pertussis in Escherichia coli and in vitro.
DNA vaccine encoding pertussis toxin S1 subunit induces protection against Bordetella pertussis in mice.
Do beta 2-adrenergic receptors modulate Ca2+ in adult rat ventricular myocytes?
Do early childhood immunizations influence the development of atopy and do they cause allergic reactions?
DOCA-enhanced sites of vasopressin-stimulated cAMP formation in rat cortical collecting tubule.
Does Bordetella pertussis vaccine offer any cross-protection against Bordetella bronchiseptica? Implications for pet owners with cystic fibrosis.
Does Breastfeeding Protect Young Infants From Pertussis? Case-control Study and Immunologic Evaluation.
Does cyclic guanosine monophosphate mediate noradrenaline-induced inhibition of islet insulin secretion stimulated by glucose and palmitate?
Does interleukin 2 stimulus-response coupling result in generation of intracellular second messengers?
Does the guanine nucleotide regulatory protein Ni mediate progesterone inhibition of Xenopus oocyte adenylate cyclase?
Does whole-cell pertussis vaccine protect black South African infants? Assessment of post-vaccination events and antibody responses to pertussis toxin, filamentous haemagglutinin and agglutinogens 2 and 3.
Domain-dependent action of urokinase on smooth muscle cell responses.
Dominance of G(s) in doubly G(s)/G(i)-coupled chimaeric A(1)/A(2A) adenosine receptors in HEK-293 cells.
Dominant role of betagamma subunits of G-proteins in oxytocin-evoked burst firing.
Dopamine (D2) or gamma-aminobutyric acid (GABAB) receptor activation hyperpolarizes rat melanotrophs and pertussis toxin blocks these responses and the accompanying fall in [Ca2+]i.
Dopamine actions on calcium currents, potassium currents and hormone release in rat melanotrophs.
Dopamine activates inward rectifier K+ channel in acutely dissociated rat substantia nigra neurones.
Dopamine agonist inhibits vascular endothelial growth factor protein production and secretion in granulosa cells.
Dopamine agonist-mediated inhibition of acetylcholine release in rat striatum is modified by thyroid hormone status.
Dopamine D(2) receptor activation causes mitogenesis via p44/42 mitogen-activated protein kinase in opossum kidney cells.
Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent.
Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal.
Dopamine D2 receptor regulation of the dopamine transporter expressed in Xenopus laevis oocytes is voltage-independent.
Dopamine D2 receptor stimulation of Na+/H+ exchange assessed by quantification of extracellular acidification.
Dopamine D2 receptors modulate pyramidal neurons in mouse medial prefrontal cortex through a stimulatory G protein pathway.
Dopamine D2, receptor-mediated modulation of the GABAergic inhibition of substantia nigra pars reticulata neurons.
Dopamine D2-like receptor signaling suppresses human osteoclastogenesis.
Dopamine D2-like receptor-mediated opening of K+ channels in opossum kidney cells.
Dopamine D2L receptor couples to G alpha i2 and G alpha i3 but not G alpha i1, leading to the inhibition of adenylate cyclase in transfected cell lines.
Dopamine D2L receptors stimulate Na+/K(+)-ATPase activity in murine LTK- cells.
Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells.
Dopamine D4 receptors regulate intracellular calcium concentration in cultured chicken cone photoreceptor cells: relationship to dopamine receptor-mediated inhibition of cAMP formation.
Dopamine inhibition of NaKATPase activity in proximal convoluted tubule cells.
Dopamine inhibition of proopiomelanocortin gene expression in the intermediate lobe of the pituitary. Interactions with corticotropin-releasing factor and the beta-adrenergic receptors and the adenylate cyclase system.
Dopamine inhibition: enhancement of GABA activity and potassium channel activation in hypothalamic and arcuate nucleus neurons.
Dopamine inhibits a sustained calcium current through activation of alpha adrenergic receptors and a GTP-binding protein in adult rat sympathetic neurons.
Dopamine Inhibits Basal Prolactin Release in Pituitary Lactotrophs through Pertussis Toxin-Sensitive and -Insensitive Signaling Pathways.
Dopamine inhibits cytosolic Ca2+ increases in rat lactotroph cells. Evidence of a dual mechanism of action.
Dopamine inhibits inositol phosphate production, arachidonic acid formation, and corticosteroid release by frog adrenal gland through a pertussis toxin-sensitive G-protein.
Dopamine inhibits prolactin secretion stimulated by the calcium channel agonist Bay-K-8644 through a pertussis toxin-sensitive G protein in anterior pituitary cells.
Dopamine inhibits two characterized voltage-dependent calcium currents in identified rat lactotroph cells.
Dopamine neuron membrane physiology: characterization of the transient outward current (IA) and demonstration of a common signal transduction pathway for IA and IK.
Dopamine presynaptically depresses fast inhibitory synaptic transmission via D4 receptor-protein kinase A pathway in the rat dorsolateral septal nucleus.
Dopamine regulates cell cycle regulatory proteins via cAMP, Ca(2+)/PKC, MAPKs, and NF-kappaB in mouse embryonic stem cells.
Dopamine regulates phosphate uptake by opossum kidney cells through multiple counter-regulatory receptors.
Dopamine regulates the electrical activity of frog melanotrophs through a G protein-mediated mechanism.
Dopamine selectively induces migration and homing of naive CD8+ T cells via dopamine receptor D3.
Dopamine stimulates 45Ca2+ uptake through cAMP, PLC/PKC, and MAPKs in renal proximal tubule cells.
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
Dopamine-induced inhibition of endogenous acetylcholine release from the isolated ileal synaptosomal preparations of guinea-pig mediated via alpha-adrenoceptors.
Dopamine-induced synaptic depression in the parabrachial nucleus is independent of CTX- and PTX-sensitive G-proteins, PKA and PLC signalling pathways.
Dopaminergic inhibition of catecholamine secretion from chromaffin cells: evidence that inhibition is mediated by D4 and D5 dopamine receptors.
Dopaminergic inhibition of DNA synthesis in pituitary tumor cells is associated with phosphotyrosine phosphatase activity.
Dopaminergic receptors linked to adenylate cyclase in human cerebromicrovascular endothelium.
Dopaminergic regulation of dopamine release from PC12 cells via a pertussis toxin-sensitive G protein.
Dopaminergic transmission between identified neurons from the mollusk, Lymnaea stagnalis.
Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells: differential involvement of adenosine.
Dose-dependent activation of Ca2+-activated K+ channels by ethanol contributes to improved endothelial cell functions.
Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord.
Down-modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis.
Down-regulation of Gi sub-types by prolonged incubation of adipocytes with an A1 adenosine receptor agonist.
Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling.
DsbA and DsbC are required for secretion of pertussis toxin by Bordetella pertussis.
DTaP vaccines from north american vaccine (NAVA): composition and critical parameters.
Dual coupling of cloned human 5-hydroxytryptamine1D alpha and 5-hydroxytryptamine1D beta receptors stably expressed in murine fibroblasts: inhibition of adenylate cyclase and elevation of intracellular calcium concentrations via pertussis toxin-sensitive G protein(s).
Dual coupling of heterologously-expressed rat P2Y6 nucleotide receptors to N-type Ca2+ and M-type K+ currents in rat sympathetic neurones.
Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein.
Dual effect of thrombin on voltage-dependent Ca2+ channels of portal vein smooth muscle cells.
Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission.
Dual effects of angiotensin II on calcium currents in neonatal rat nodose neurons.
Dual effects of calcitonin and calcitonin gene-related peptide on intracellular cyclic 3',5'-monophosphate in a human breast cancer cell line.
Dual effects of DAMGO [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin and CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) on adenylyl cyclase activity: implications for mu-opioid receptor Gs coupling.
Dual effects of endothelins -1, -2 and -3 on guinea pig field-stimulated ileum: possible mediation by two receptors coupled to pertussis toxin-insensitive mechanisms.
Dual effects of hexanol and halothane on the regulation of calcium sensitivity in airway smooth muscle.
Dual effects of mastoparan on intracellular free Ca2+ concentrations in human astrocytoma cells.
Dual effects of muscarinic M(2) acetylcholine receptors on the synthesis of cyclic AMP in CHO cells: dependence on time, receptor density and receptor agonists.
Dual effects of pertussis toxin on in vitro invasive behavior of metastatic lymphoma variants.
Dual effects of pertussis toxin on lymphoid cells in culture.
Dual effects of pertussis toxin on murine neutrophils in vivo. I. Pertussis toxin inhibits extravasation potential of mature neutrophils while simultaneously stimulating granulopoiesis.
Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells.
Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule.
Dual mechanisms involved in the development of diverse biological activities of islet-activating protein, (pertussis toxin) as revealed by chemical modification of the toxin molecule.
Dual modulation by adenosine of ATP-activated channels through GTP-binding proteins in rat pheochromocytoma PC12 cells.
Dual modulation by adenosine of gastrin release from canine G-cells in primary culture.
Dual modulation of an inwardly rectifying potassium conductance.
Dual modulation of calcium channel current via recombinant alpha2-adrenoceptors in pheochromocytoma (PC-12) cells.
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.
Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture.
Dual pathways for GTP-dependent regulation of chemoattractant-activated K+ conductance in murine J774 monocytes.
Dual pathways of receptor-mediated cyclic GMP generation in NG108-15 cells as differentiated by susceptibility to islet-activating protein, pertussis toxin.
Dual pertussis toxin-sensitive pathway of zymosan-induced activation in guinea pig macrophages. An anti-CR3 antibody-inhibitable stimulation of phagocytosis and -resistant stimulation of O2- production and arachidonate release.
Dual regulation by mu, delta and kappa opioid receptor agonists of K+ conductance of DRG neurons and neuroblastoma X DRG neuron hybrid F11 cells.
Dual regulation of cyclic AMP formation by thrombin in HEL cells, a leukaemic cell line with megakaryocytic properties.
Dual regulation of human syncytial adenylyl cyclase.
Dual regulation of neutrophil adenylate cyclase by fluoride and its relationship to cellular activation.
Dual regulation of PLA2 and PGI2 production by G proteins in bovine aortic endothelial cells.
Dual regulation of PTH-stimulated adenylate cyclase activity by GTP.
Dual role of GTP-binding proteins in the control of endothelial prostacyclin.
Dual signal transduction through delta opioid receptors in a transfected human T-cell line.
Dual signaling and effector pathways mediate human eosinophil activation by platelet-activating factor.
Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.
Dual Transmembrane Signalling Mechanisms in Eosinophils: Evidence for Two Functionally Distinct Receptors for Platelet-Activating Factor.
Duality in the mastoparan action on glucose transport in rat adipocytes.
Duality of G protein-coupled mechanisms for beta-adrenergic activation of NKCC activity in skeletal muscle.
Duration of protection against Bordetella pertussis infection elicited by whole-cell and acellular vaccine priming in Polish children and adolescents.
Dynamic Mass Redistribution as a Means to Measure and Differentiate Signaling via Opioid and Cannabinoid Receptors.
Dynamic regulation of glycinergic input to spinal dorsal horn neurones by muscarinic receptor subtypes in rats.
Dynamics of fast synaptic excitation during trains of stimulation in myenteric neurons of guinea-pig ileum.
Dynamics of pertussis toxin IgG after symptomatic pertussis in children and adults.
Dynamics of the diradylglycerol responses of stimulated phagocytes.
Dynorphin A and cAMP-dependent protein kinase independently regulate neuronal calcium currents.
Dynorphins directly inhibit neuronal nicotinic acetylcholine receptors in PC12 cells.
Dysfunction of the beta- and alpha-adrenergic systems in a model of congestive heart failure. The pacing-overdrive dog.
Early alterations of Gi/Go protein-dependent transductional processes in the retina of diabetic animals.
Early IFN-? production together with decreased expression of TLR3 and TLR9 characterizes EAE development conditional on the presence of myelin.
Early PDGF-induced alterations in cytosolic free calcium are required for mitogenesis.
Early reversible induction of leukotriene synthesis in chicken myelomonocytic cells transformed by a temperature-sensitive mutant of avian leukemia virus E26.
Early signal transduction by the receptor to the chemokine monocyte chemotactic protein-1 in a murine T cell hybrid.
Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase.
Eclosion hormone-stimulated cGMP levels in the central nervous system of Manduca sexta: inhibition by lipid metabolism blockers, increase in inositol(1,4,5)trisphosphate and further evidence against the involvement of nitric oxide.
Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway.
EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition.
EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16.
Effect of 12-hydroxyeicosatetraenoic acid on cytosolic calcium in human neutrophils.
Effect of 5-hydroxytryptamine on intracellular calcium dynamics in cultured rat vascular smooth muscle cells.
Effect of acellular pertussis vaccine on the development of allergic sensitization to environmental allergens in adults.
Effect of adenosine deaminase, N6-phenylisopropyladenosine and hypothyroidism on the responsiveness of rat brown adipocytes to noradrenaline.
Effect of adenosine on the ouabain-insensitive Na+-ATPase activity from basolateral membrane of the proximal tubule.
Effect of adenylate cyclase stimulation on meiotic resumption and cyclic AMP content of zona-free and cumulus-enclosed bovine oocytes in vitro.
Effect of age on vascular beta2-adrenergic receptor desensitization is not mediated by the receptor coupling to Galphai proteins.
Effect of alpha-adrenoceptor subtype-selective inverse agonists on non-pregnant and late-pregnant cervical resistance in vitro in the rat.
Effect of alpha2-adrenoceptor stimulation on isolated canine Purkinje fiber contraction.
Effect of angiotensin converting enzyme (ACE) and angiotensins on human sperm functions.
Effect of angiotensin II and III on inositol polyphosphate production in differentiated NG108-15 hybrid cells.
Effect of Aspergillus terreus mycotoxins on nitric oxide synthase activity in human erythroid K-562 cells.
Effect of atrial natriuretic peptide on reactive oxygen species-induced by hydrogen peroxide in THP-1 monocytes: role in cell growth, migration and cytokine release.
Effect of atriopeptin II on Ca influx, contractile behavior and cyclic nucleotide content of cultured neonatal rat myocardial cells.
Effect of bacterial toxins on human B cell activation. I. Mitogenic activity of pertussis toxin.
Effect of bacterial toxins on spermine-induced inhibition of adenylate cyclase activity of cultured heart cells.
Effect of BIBP3226 on inositol phosphate accumulation and cytosolic calcium level in control and NPY Y1 receptor expressing CHO-K1 cells.
Effect of Bordetella pertussis toxin on ADP-ribosylation of membrane proteins, adenylate cyclase activity and insulin release in rat pancreatic islets.
Effect of calcitonin gene-related peptide on skeletal muscle via specific binding site and G protein.
Effect of carbachol in the absence and presence of phenylephrine on Rb+ efflux and tension in rabbit left atria.
Effect of cholera toxin and pertussis toxin on opioid tolerance and dependence in the guinea-pig myenteric plexus.
Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes.
Effect of cholera toxin and pertussis toxin on the growth of A431 cells: kinetics of cyclic AMP and inositol trisphosphate in toxin-treated cells.
Effect of cholera toxin on histamine release from bone marrow-derived mouse mast cells.
Effect of chronic D-Ala,2 D-Leu5-enkephalin or pertussis toxin treatment on the high-affinity state of delta opioid receptor in neuroblastoma x glioma NG108-15 hybrid cells.
Effect of combination with an acellular pertussis, diphtheria, tetanus vaccine on antibody response to Hib vaccine (PRP-T).
Effect of D-glucose feeding on mortality induced by sepsis.
Effect of delta-opioid antagonists on the functional coupling between opioid receptors and G-proteins in rat brain membranes.
Effect of different detoxification procedures on the residual pertussis toxin activities in vaccines.
Effect of dihydroergocryptine and dihydroergocristine on cyclic AMP accumulation and prolactin release in vitro: evidence for a dopaminomimetic action.
Effect of elastin peptides and N-formyl-methionyl-leucyl phenylalanine on cytosolic free calcium in polymorphonuclear leukocytes of healthy middle-aged and elderly subjects.
Effect of endothelin-1 on phospholipase D activity in osteoblast-like cells.
Effect of erythromycin treatment on antibody responses in pertussis.
Effect of fluoride, pertussis and cholera toxin on the release of arachidonic acid and the formation of prostaglandin E2, D2, superoxide and inositol phosphates in rat liver macrophages.
Effect of G protein heterotrimer composition on coupling of neurotransmitter receptors to N-type Ca(2+) channel modulation in sympathetic neurons.
Effect of GABA Receptor Agonists or Antagonists Injected Spinally on the Blood Glucose Level in Mice.
Effect of gender, race, and parental education on immunogenicity and reported reactogenicity of acellular and whole-cell pertussis vaccines.
Effect of GHRH and peptides from the vasoactive intestinal peptide family on cAMP production of human cancer cell lines in vitro.
Effect of Gi protein ADP-ribosylation induced by pertussis toxin on dopamine-mediated behaviors.
Effect of granulocyte-macrophage colony-stimulating factor on superoxide production in cytoplasts and intact human neutrophils: role of protein kinase and G-proteins.
Effect of heat inactivation of serum on Bordetella pertussis antibody determination by enzyme-linked immunosorbent assay.
Effect of heat shock, [Ca2+]i, and cAMP on inositol trisphosphate in human epidermoid A-431 cells.
Effect of heptakis (2,6-0-dimethyl)beta-cyclodextrin on cell growth and the production of pertussis toxin and filamentous hemagglutinin in Bordetella pertussis.
Effect of heptakis (2,6-O-dimethyl) beta-cyclodextrin on the production of pertussis toxin by Bordetella pertussis.
Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children.
Effect of hydrogen peroxide on VIP-induced relaxation of the cat lower esophageal sphincter.
Effect of hydromechanical forces on the production of filamentous haemagglutinin and pertussis toxin of Bordetella pertussis.
Effect of hyperreactivity to endotoxin on the toxicity of pertussis vaccine and pertussis toxin in mice.
Effect of ICV pertussis toxin and N-ethylmaleimide on the levels of substance P and serotonin in brain and spinal cord of the rat.
Effect of IL-1 beta on responses of cultured human airway smooth muscle cells to bronchodilator agonists.
Effect of in vivo injection of cholera and pertussis toxin on glucose transport in rat skeletal muscle.
Effect of inactivated poliovirus vaccine on the antibody response to Bordetella pertussis antigens when combined with diphtheria-pertussis-tetanus vaccine.
Effect of inhibitors of distinct signalling pathways on neutrophil Q2- generation in response to tumor necrosis factor-alpha, and antibodies against CD18 and CD11a: evidence for a common and unique pattern of sensitivity to wortmannin and protein tyrosine kinase inhibitors.
Effect of insulin and angiotensin II on cell calcium in human skin fibroblasts.
Effect of intrathecal injection of pertussis toxin on substance P, norepinephrine and serotonin contents in various neural structures of arthritic rats.
Effect of islet-activating pertussis toxin on the binding characteristics of Ca2+-mobilizing hormones and on agonist activation of phosphorylase in hepatocytes.
Effect of light on phosphatidate phosphohydrolase activity of retina rod outer segments: the role of transducin.
Effect of Linker Length and Composition on Heterobivalent Ligand-Mediated Receptor Cross-Talk between the A1 Adenosine and ?2 Adrenergic Receptors.
Effect of local massage on vaccination: DTP and DTPa.
Effect of low-density lipoproteins, mevinolin, and G proteins on Ca2+ response in cultured chick atrial cells.
Effect of lysophosphatidic acid on motility, polarisation and metabolic burst of human neutrophils.
Effect of lysophosphatidic acid on the ovum transport in mouse oviducts.
Effect of lysophosphatidic acid on the preimplantation development of mouse embryos.
Effect of lysophosphatidylglycerol on several signaling molecules in OVCAR-3 human ovarian cancer cells: involvement of pertussis toxin-sensitive G-protein coupled receptor.
Effect of monoclonal antibody to pertussis toxin on toxin activity.
Effect of mutations causing overexpression of RNA polymerase alpha subunit on regulation of virulence factors in Bordetella pertussis.
Effect of N6-(L-2-phenylisopropyl)adenosine and insulin on cAMP metabolism in 3T3-L1 adipocytes.
Effect of neurotransmitters on axoplasmic transport: acetylcholine effect on superior cervical ganglion cells.
Effect of NMDA receptor ligands on mast cell histamine release, a reappraisal.
Effect of nonhydrolyzable guanosine phosphate on IgE-mediated activation of phospholipase C and histamine release from rodent mast cells.
EFFECT OF PEPTIDOGLYCANE OF STAPHYLOCOCCUS AUREUS CELL WALL ON THE MECHANISM OF REGULATION OF CONTRACTILE ACTIVITY OF RAT MYOMETRIUM BY ADENYLATE CYCLASE SYSTEM.
Effect of pertussis and cholera toxins administered supraspinally on CA3 hippocampal neuronal cell death and the blood glucose level induced by kainic acid in mice.
Effect of pertussis pretreatment on plasma glucose and insulin responses to lithium in rats.
Effect of pertussis toxin and B-oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages.
Effect of pertussis toxin and herbimycin A on proteinase-activated receptor 2-mediated cyclooxygenase 2 expression in Helicobacter pylori-infected gastric epithelial AGS cells.
Effect of pertussis toxin and N-ethylmaleimide on voltage-dependent and -independent calcium current modulation in serotonergic neurons.
Effect of pertussis toxin and neomycin on G-protein-regulated polyphosphoinositide phosphodiesterase. A comparison between HL60 membranes and permeabilized HL60 cells.
Effect of pertussis toxin and PGE2 on the functioning of the IL-2 promoter in interleukin-1 treated EL4.NOB-1 thymoma cells.
Effect of pertussis toxin and the cGMP lowering agent LY83583 on the relaxation induced by nitrates in isolated bovine mesenteric artery. A comparison between glyceryl trinitrate, isosorbide dinitrate and isosorbide 5-mononitrate.
Effect of pertussis toxin injected into the ventral tegmental area on amphetamine-induced Fos protein in the nucleus accumbens.
Effect of pertussis toxin on A1-receptor-mediated inhibition of insulin secretion.
Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists.
Effect of pertussis toxin on baclofen- and diphenhydramine-induced amnesia.
Effect of pertussis toxin on calcium influx in three contraction models.
Effect of pertussis toxin on hormonal responsiveness of rat hepatocytes.
Effect of pertussis toxin on insulin-induced signal transduction in rat adipocytes and soleus muscles.
Effect of pertussis toxin on islet insulin secretion in obese (fa/fa) Zucker rats.
Effect of pertussis toxin on morphine, diphenhydramine, baclofen, clomipramine and physostigmine antinociception.
Effect of pertussis toxin on normorphine-dependence and on acute inhibitory effects of normorphine and clonidine in guinea-pig isolated ileum.
Effect of pertussis toxin on parathyroid hormone-stimulated cyclic AMP production in cultured kidney cells.
Effect of pertussis toxin on radioligand binding to rat brain adenosine A1 receptors.
Effect of pertussis toxin on susceptibility of infant rats to Haemophilus influenzae type b.
Effect of pertussis toxin on the adrenergic regulation of plasma renin activity.
Effect of pertussis toxin on the heart acetylcholine muscarinic receptor affinity.
Effect of pertussis toxin on the heart muscarinic-cholinergic receptors and their function.
Effect of pertussis toxin on the hormonal regulation of cyclic AMP levels in hamster fat cells.
Effect of pertussis toxin on the induction of nitric oxide synthesis in murine macrophages and on protection in vivo.
Effect of pertussis toxin on the inhibition of secretory activity by prostaglandin E2, somatostatin, epidermal growth factor and 12-O-tetradecanoylphorbol 13-acetate in parietal cells from rat stomach.
Effect of pertussis toxin on the interaction of azepexole and halothane.
Effect of pertussis toxin on the phosphodiesteratic cleavage of the polyphosphoinositides by guanosine 5'-O-thiotriphosphate and thrombin in permeabilized human platelets.
Effect of pertussis toxin on the response of rat medial prefrontal cortex cells to the iontophoresis of serotonin receptor agonists.
Effect of pertussis toxin on water metabolism in the rat.
Effect of pertussis toxin pretreated centrally on blood glucose level induced by stress.
Effect of pertussis toxin treatment on postjunctional alpha-1 and alpha-2 adrenoceptor function in the cardiovascular system of the pithed rat.
Effect of pertussis toxin treatment on the down-regulation of opiate receptors in neuroblastoma X glioma NG108-15 hybrid cells.
Effect of pertussis toxin treatment on the putative adenosine A3 receptor-mediated hypotensive response in the rat.
Effect of phenylephrine and prazosin on the somatostatinergic system in the rat frontoparietal cortex.
Effect of phorbol ester and pertussis toxin on the enhancement of noradrenaline release by angiotensin II in mouse atria.
Effect of platelet-activating factor (PAF) on cytosolic free calcium in human peripheral blood mononuclear leukocytes.
Effect of prednisolone on the toxicity of Bordetella pertussis for mice.
Effect of prenylcysteine analogues on chemoattractant receptor-mediated G protein activation.
Effect of Prepregnancy Pertussis Vaccination in Young Infants.
Effect of pretreatment with pertussis toxin on the development of physical dependence on morphine.
Effect of priming with diphtheria and tetanus toxoids combined with whole-cell pertussis vaccine or with acellular pertussis vaccine on the safety and immunogenicity of a booster dose of an acellular pertussis vaccine containing a genetically inactivated pertussis toxin in fifteen- to twenty-one-month-old children. Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine.
Effect of prostaglandin E2 on phospholipase D activity in osteoblast-like MC3T3-E1 cells.
Effect of prostaglandin F2 alpha on Ca2+ influx in osteoblast-like cells: function of tyrosine kinase.
Effect of prostaglandin F2 alpha on human parathyroid adenomas: evidence for uncoupling of parathyroid hormone secretion and cAMP accumulation.
Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver.
Effect of protein kinase C inhibitor (H-7) and calmodulin antagonist (W-7) on pertussis toxin-induced IL-1 production by human adherent monocytes. Comparison with lipopolysaccharide as a stimulator of IL-1 production.
Effect of proteolytic enzymes, storage and reduction on the structure and biological activity of pertussigen, a toxin from Bordetella pertussis.
Effect of PT-treatment on ANP-mediated inhibition of adenylate cyclase and amylase release in rat parotid gland.
Effect of ranakinin, a novel tachykinin, on cytosolic free calcium in frog adrenochromaffin cells.
Effect of ras-gene transformation on the inhibition of NIH3T3 cell growth by pertussis toxin.
Effect of relevant culture parameters on Pertussis Toxin expression by Bordetella pertussis.
Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS.
Effect of retinoic acid on prostaglandin F2 alpha-induced prostaglandin E2 synthesis in osteoblast-like cells.
Effect of schedule on reactogenicity and antibody persistence of acellular and whole-cell pertussis vaccines: value of laboratory tests as predictors of clinical performance.
Effect of site-directed mutagenic alterations on ADP-ribosyltransferase activity of the A subunit of Escherichia coli heat-labile enterotoxin.
Effect of sodium fluoride on the generation of lipoxygenase products from human polymorphonuclear granulocytes, mononuclear cells and platelets--indication for the involvement of G proteins.
Effect of somatostatin on adenylate cyclase activity in normal and neoplastic thyroid tissue.
Effect of somatostatin on contractile and relaxant responses of tracheal smooth muscle in rabbits.
Effect of sphingosine derivatives on calcium fluxes in thyroid FRTL-5 cells.
Effect of Sphingosine-1-Phosphate on Intracellular Free Ca2+ in Cat Esophageal Smooth Muscle Cells.
Effect of substance P and neurokinin A on rat parietal cell function.
Effect of sulpiride on somatostatin receptors, somatostatin-like immunoreactivity and modulation of adenylyl cyclase activity in the rat brain.
Effect of temperature and host factors on the activities of pertussis toxin and Bordetella adenylate cyclase.
Effect of the genetic background and specific mutation on adenylate cyclase activity in obesity syndromes.
Effect of thrombin on calcium homeostasis in chick embryonic heart cells. Receptor-operated calcium entry with inositol trisphosphate and a pertussis toxin-sensitive G protein as second messengers.
Effect of thyroid hormones on G proteins in synaptosomes of chick embryo.
Effect of transforming growth factor-alpha and parathyroid hormone-related protein on phosphate transport in renal cells.
Effect of trifluoperazine on renal epithelioid Madin-Darby canine kidney cells.
Effect of tumor necrosis factor and granulocyte/macrophage colony-stimulating factor on neutrophil degranulation.
Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.
Effect of tumor necrosis factor-alpha on the reciprocal G-protein-induced regulation of norepinephrine release by the alpha2-adrenergic receptor.
Effect of tumor necrosis factor-alpha on the stimulus-coupled responses of neutrophils and their modulation by various inhibitors.
Effect of vaccination on Bordetella pertussis strains, China.
Effector coupling mechanisms of the cloned 5-HT1A receptor.
Effector coupling of somatostatin receptor subtypes on human endocrine tumors.
Effector coupling of stably transfected human A3 adenosine receptors in CHO cells.
Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation.
Effects and mechanisms of melatonin on immune responses in mice of different months.
Effects and mechanisms of melatonin on inflammatory and immune responses of adjuvant arthritis rat.
Effects of (+)-pentazocine and 1,3-di-o-tolylguanidine (DTG), sigma (sigma) ligands, on micturition in anaesthetized rats.
Effects of 5-oxo-6,8,11,14-eicosatetraenoic acid on expression of CD11b, actin polymerization, and adherence in human neutrophils.
Effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F2 alpha on the release of noradrenaline from the isolated rat stomach.
Effects of acidic and basic fibroblast growth factors on osteoblastic cells.
Effects of adenosine A1-agonist and -antagonist on urinary volume and Na excretion in IAP-treated and non-treated rats.
Effects of adenosine analog PIA (n-phenylisopropyladenosine) on FSH-stimulated cyclic AMP (cAMP) production in the rat seminiferous epithelium.
Effects of adenosine and pertussis toxin on lipolysis in adipocytes from exercise-trained male rats.
Effects of adenosine on cAMP production and cytosolic Ca2+ in cultured rabbit medullary thick limb cells.
Effects of adenosine receptor and muscarinic cholinergic receptor agonists on cardiac protein phosphorylation. Influence of pertussis toxin.
Effects of adenylate cyclase toxin from Bordetella pertussis on human neutrophil interactions with Coccidioides immitis and Staphylococcus aureus.
Effects of ADP-ribosylation of GTP-binding protein by pertussis toxin on immunoglobulin E-dependent and -independent histamine release from mast cells and basophils.
Effects of age on muscarinic agonist-induced contraction and IP accumulation in airway smooth muscle.
Effects of alpha 2-adrenergic agonism, imidazolines, and G-protein on insulin secretion in beta cells.
Effects of alpha 2-adrenergic agonist preincubation on subsequent forskolin-stimulated adenylate cyclase activity and [3H]forskolin binding in membranes from HT29 cells.
Effects of angiotensin II and angiotensin III on airway epithelial short-circuit current: involvement of pertussis toxin-sensitive G protein.
Effects of angiotensin II and nonpeptide receptor antagonists on transduction pathways in rat proximal tubule.
Effects of angiotensin II on the action potential durations of atrial myocytes in hypertensive rats.
Effects of ATP on phosphoinositide hydrolysis and prostaglandin E2 generation in rabbit astrocytes.
Effects of beta-casomorphins on neuronal survival in culture of embryonic chick dorsal root ganglion neurons.
Effects of beta-endorphin on mu and delta opioid receptor-coupled G-protein activity: low-Km GTPase studies.
Effects of beta-phenylethylamine on dopaminergic neurons of the ventral tegmental area in the rat: a combined electrophysiological and microdialysis study.
Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo.
Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification.
Effects of Bordetella pertussis toxin on catecholamine inhibition of insulin release from intact and electrically permeabilized rat islets.
Effects of Bordetella pertussis toxin pretreatment on the antiarrhythmic action of ischaemic preconditioning in anaesthetized rats.
Effects of Bu Shen Yi sui capsule on NogoA/NgR and its signaling pathways RhoA/ROCK in mice with experimental autoimmune encephalomyelitis.
Effects of calcium channel antagonists and pertussis toxin on noradrenaline-induced contractions in pulmonary artery from pulmonary hypertensive rats.
Effects of calcium on light-activated GTP-binding proteins in squid photoreceptor membranes.
Effects of calcium-antagonists on dopamine release in the central nervous system--possible interactions with D2-autoreceptors and guanosine triphosphate-binding proteins.
Effects of cannabidiol on the function of ?7-nicotinic acetylcholine receptors.
Effects of cannabinoids on caffeine contractures in slow and fast skeletal muscle fibers of the frog.
Effects of cannabinoids on synaptic transmission in the frog neuromuscular junction.
Effects of cannabinoids on tension induced by acetylcholine and choline in slow skeletal muscle fibers of the frog.
Effects of CB(1) cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activity.
Effects of cholera and pertussis toxins on prolactin stimulation of lactose synthesis and ornithine decarboxylase activity in mouse mammary gland explants.
Effects of chronic morphine exposure on opioid inhibition of adenylyl cyclase in 7315c cell membranes: a useful model for the study of tolerance at mu opioid receptors.
Effects of chronic receptor blockade on excitation-contraction coupling in rat aortic rings.
Effects of clenbuterol on contractility and Ca2+ homeostasis of isolated rat ventricular myocytes.
Effects of continuous exposure to stromal cell-derived factor-1 alpha on T cell rolling and tight adhesion to monolayers of activated endothelial cells.
Effects of cyclic AMP-affecting agents on contractile reactivity of isolated mesenteric and renal resistance arteries of the rat.
Effects of cyclosporine A on cyclic AMP generation and GTP-binding proteins in isolated islets.
Effects of dexamethasone and indomethacin on the vascular beta 2-adrenolytic action of pertussis toxin in rats; a prostaglandin-mediated phenomenon.
Effects of diethyldithiocarbamate on activating mechanisms of neutrophils.
Effects of drugs acting on adrenergic and adenosine receptors on the intraocular pressure and the activity of adenylyl cyclase in ciliary processes and their sensitivity to pertussis toxin.
Effects of ECL cell extracts and granule/vesicle-enriched fractions from rat oxyntic mucosa on cAMP and IP(3) in rat osteoblast-like cells.
Effects of endogenous cannabinoid anandamide on cardiac Na(+)/Ca(2+) exchanger.
Effects of endogenous cannabinoid anandamide on excitation-contraction coupling in rat ventricular myocytes.
Effects of endothelin on mitogen-activated protein kinase activity and protein synthesis in isolated adult feline cardiac myocytes.
Effects of endothelin on rat renal proximal tubule Na(+)-Pi cotransport and Na+/H+ exchange.
Effects of endothelin-1 on Ca2+ signaling in guinea-pig ventricular myocytes: role of protein kinase C.
Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation.
Effects of epidermal growth factor on signal transduction in rabbit parietal cells.
Effects of estrogenic xenobiotics on human and mouse spermatozoa.
Effects of ethanol in vitro on the beta adrenergic receptor-coupled adenylate cyclase system.
Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver.
Effects of exercise on myocardial adenylate cyclase and Gi alpha expression in senescence.
Effects of extracellular nucleotides in the pituitary: adenosine triphosphate receptor-mediated intracellular responses in gonadotrope-derived alpha T3-1 cells.
Effects of fluoride and cholera and pertussis toxins on sensory transduction in the carotid body.
Effects of follicle stimulating hormone, cholera toxin, pertussis toxin and forskolin on adenosine cyclic 3',5'-monophosphate output by granulosa cells from Booroola ewes with or without the F gene.
Effects of G protein and cGMP on phytochrome-mediated amaranthin synthesis inAmaranthus caudatus seedlings.
Effects of galanin on amylase secretion from dispersed rat pancreatic acini.
Effects of genistein, tyrphostin, and pertussis toxin on EGF-induced mitogenesis in primary culture and clonal osteoblastic cells.
Effects of ginsenoside on G protein-coupled inwardly rectifying K(+) channel activity expressed in Xenopus oocytes.
Effects of glucagon like peptide-1(7-36) amide on the cytoplasmic Ca(2+)-concentration in rat islet cells.
Effects of GTP gamma S on muscarinic receptor-stimulated inositol phospholipid hydrolysis in permeabilized smooth muscle from the small intestine.
Effects of GTP, forskolin, sodium fluoride, serotonin, dopamine, and carbachol on adenylate cyclase in Teleost retina.
Effects of guanyl nucleotides and rhodopsin on ADP-ribosylation of the inhibitory GTP-binding component of adenylate cyclase by pertussis toxin.
Effects of histamine on polyphosphoinositide metabolism in NG108-15 cells.
Effects of histamine on the metabolism of isolated rat hepatocytes: roles of H1- and H2-histamine receptors.
Effects of homo- and heterodimeric isoforms of PDGF on signalling events in rat renal mesangial cells.
Effects of human fibroblasts on invasiveness of oral cancer cells in vitro: isolation of a chemotactic factor from human fibroblasts.
Effects of human low-density lipoproteins on superoxide production by formyl-methionyl-leucyl-phenylalanine activated polymorphonuclear leukocytes.
Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity.
Effects of insulin on inositol phosphate production in cultured rat hepatocytes.
Effects of insulin, adenosine, and prostaglandin on alpha-adrenergic-stimulated respiration in brown adipocytes.
Effects of insulin, pertussis toxin and cholera toxin on protein synthesis and diacylglycerol production in 3T3 fibroblasts: evidence for a G-protein mediated activation of phospholipase C in the insulin signal mechanism.
Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes.
Effects of interleukin-1 on calcium signaling and the increase of filamentous actin in isolated and in situ articular chondrocytes.
Effects of intrapancreatic neuronal activation on cholecystokinin-induced exocrine secretion of isolated perfused rat pancreas.
Effects of intrathecal or intracerebroventricular pretreatment with pertussis toxin on antinociception induced by beta-endorphin or morphine administered intracerebroventricularly in mice.
Effects of islet-activating protein on insulin- and isoprenaline-stimulated glucose transport in isolated rat adipocytes.
Effects of isoflurane on voltage-dependent calcium fluxes in rabbit T-tubule membranes: comparison with alcohols.
Effects of kappa- and mu-opioid receptor agonists on Ca2+ channels in neuroblastoma cells: involvement of the orphan opioid receptor.
Effects of lidocaine on sarcolemmal fluidity and cellular cAMP in rat cardiomyocytes.
Effects of lithium ion on ADP ribosylation of inhibitory GTP-binding protein by pertussis toxin, islet-activating protein.
Effects of lithium on receptor-mediated activation of G proteins in rat brain cortical membranes.
Effects of litter removal on the lipolytic response and the regulatory components of the adenylate cyclase in adipocytes isolated from lactating rats.
Effects of locally applied D1 and D2 agonists on striatal neurons with 6-OHDA and pertussis toxin lesions.
Effects of low density lipoproteins and mevinolin on cholesterol content and muscarinic cholinergic responsiveness in cultured chick atrial cells. Regulation of levels of muscarinic receptors and guanine nucleotide regulatory proteins.
Effects of low-sodium diet on regulation of platelet alpha 2-adrenergic receptors in young and elderly humans.
Effects of lysophosphatidic acid on proliferation of stellate cells and hepatocytes in culture.
Effects of mastoparan and related peptides on phosphoinositide breakdown in HL-60 cells and cell-free preparations.
Effects of mutations on enzyme activity and immunoreactivity of the S1 subunit of pertussis toxin.
Effects of neuropeptide Y on cell length and membrane currents in isolated guinea pig ventricular myocytes.
Effects of neuropeptide Y on forskolin, alpha 2- and beta-adrenoceptor-regulated cAMP levels in the rat brain slice.
Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy.
Effects of nifedipine, BAY K 8644, and pertussis toxin on pressor response to sarafotoxin-b in pithed rats.
Effects of nitric oxide on adenylyl cyclase stimulation in N18TG2 neuroblastoma cells.
Effects of oestradiol and tamoxifen on oxytocin-induced phospholipase C activation in human myometrial cells.
Effects of orexin (hypocretin) on GIRK channels.
Effects of organometals on cellular signaling. I. Influence of metabolic inhibitors on metal-induced arachidonic acid liberation.
Effects of parathyroid hormone on cytosolic calcium of rat adipocytes.
Effects of parathyroid hormone-related protein on human mesangial cells in culture.
Effects of Pasteurella haemolytica A1 culture supernatant on mechanisms controlling bovine alveolar macrophage oxygen radical production.
Effects of pertussis and cholera toxin on the interferon-gamma stimulated immunocytochemical staining of ICAM-1 and inositol phosphate formation in a human renal carcinoma cell line.
Effects of pertussis and cholera toxins on alpha-adrenoceptor function in rat tail artery: differences in hypertension.
Effects of pertussis toxin (PT) on T-cell populations sensitized for delayed-type hypersensitivity in mice.
Effects of pertussis toxin and galpha-protein-specific antibodies on phosphoinositide hydrolysis in rat brain membranes after cholinergic denervation and hippocampal sympathetic ingrowth.
Effects of pertussis toxin and indomethacin on murine lymphocytes in the bronchoalveolar lavage fluids.
Effects of pertussis toxin and its binding subunit on IL-1 signalling in T cells.
Effects of pertussis toxin on adenylate cyclase responses to prostaglandin E2 and calcitonin in human breast cancer cells.
Effects of pertussis toxin on alpha 1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat ventricular myocytes.
Effects of pertussis toxin on behavioral responses during different withdrawal periods from chronic cocaine treatment.
Effects of pertussis toxin on behavioural responses of guinea-pigs to centrally administered substance P, quinpirole, carbachol, U-50,488H, morphine and morphine withdrawal.
Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells.
Effects of pertussis toxin on caudate neuron electrophysiology: studies with dopamine D1 and D2 agonists.
Effects of pertussis toxin on D2-dopamine receptor in rat striatum: evidence for coupling of Ni regulatory protein with D2-receptor.
Effects of pertussis toxin on delayed-type hypersensitivity responses and on the activity of suppressor T cells on the responses.
Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed rats.
Effects of pertussis toxin on extracellular signal-regulated kinase activation in hepatocytes by hormones and receptor-independent agents: evidence suggesting a stimulatory role of G(i) proteins at a level distal to receptor coupling.
Effects of pertussis toxin on growth factor-stimulated inositol phosphate formation and DNA synthesis in Swiss 3T3 cells.
Effects of pertussis toxin on inhibition of synaptosomal tyrosine hydroxylase activity by apomorphine.
Effects of pertussis toxin on intraocular pressure and adenylate cyclase activity of ciliary processes in rabbits.
Effects of pertussis toxin on opioid regulation of catecholamine release from rat and guinea pig brain slices.
Effects of pertussis toxin on resorption of 19-day-old fetal rat long bones.
Effects of pertussis toxin on signal transductions via P2-purinergic receptors in A-431 human epidermoidal carcinoma cells.
Effects of pertussis toxin on the affinity of exocytosis for Ca2+ in bovine adrenal chromaffin cells.
Effects of pertussis toxin on the alpha 2-adrenoceptor-inhibitory GTP-binding protein-adenylate cyclase system in rat brain: pharmacological and neurochemical studies.
Effects of pertussis toxin on the behavioural and ECoG spectrum changes induced by clonidine and yohimbine after their microinfusion into the locus coeruleus.
Effects of pertussis toxin on the erythropoietin-stimulated proliferation and differentiation of erythroid-responsive cells.
Effects of pertussis toxin on vasodilation and cyclic GMP in bovine mesenteric arteries and demonstration of a 40 kD soluble protein ribosylation substrate for pertussis toxin.
Effects of Pertussis Toxin Suggest a Role for G-Proteins in the Inhibition of Acetylcholine Release from Rat Myenteric Plexus by Opioid and Presynaptic Muscarinic Receptors.
Effects of pertussis toxin treatment of rats on estradiol-induced adenohypophyseal growth reaction and on adrenergic lipolysis.
Effects of pertussis toxin treatment on human natural killer cell function.
Effects of pertussis toxin treatment on metabolism in hamster brown adipocytes.
Effects of pertussis toxin treatment on the metabolism of rat adipocytes.
Effects of pertussis toxin, dibutyryl-cyclic-AMP, bromo-cyclic-AMP and forskolin on the behavioural and electrocortical power spectrum changes induced by microinfusion of interleukin-2 into the locus coeruleus.
Effects of phorbol esters and pertussis toxin on agonist-stimulated cyclic AMP production in rat osteosarcoma cells.
Effects of phorbol esters and pertussis toxin on calcitonin-stimulated accumulation of cyclic AMP in neonatal mouse calvarial bones.
Effects of phosducin on the GTPase cycle of Go.
Effects of phosphorylation of inhibitory GTP-binding protein by cyclic AMP-dependent protein kinase on its ADP-ribosylation by pertussis toxin, islet-activating protein.
Effects of phosphotyrosine phosphatase inhibition on insulin secretion and intracellular signaling events in rat pancreatic islets.
Effects of prostaglandin E2 on amiloride-blockable Na+ channels in a distal nephron cell line (A6).
Effects of prostaglandins on gastrin release from canine antral mucosal cells in primary culture.
Effects of protein kinase C activation on cyclic AMP and testosterone production of rat Leydig cells in vitro.
Effects of protein kinase C and A activation on ATP-stimulated release of [3H]noradrenaline from PC12 cells.
Effects of purine and pyrimidine nucleotides on intracellular Ca2+ in human eosinophils: activation of purinergic P2Y receptors.
Effects of quinapril, losartan and hydralazine on cardiac hypertrophy and beta-adrenergic neuroeffector mechanisms in transgenic (mREN2)27 rats.
Effects of ras-encoded proteins and platelet-derived growth factor on inositol phospholipid turnover in NRK cells.
Effects of recombinant human interleukin-1 beta on accumulation of inflammatory peritoneal macrophages in mice treated with pertussis toxin.
Effects of respiratory burst inhibitors on nitric oxide production by human neutrophils.
Effects of Ro 5-4864 and PK 11195 in rat duodenum and vas deferens.
Effects of S-nitroso-cysteine on proteins that regulate exocytosis in PC12 cells: inhibitory effects on translocation of synaptophysin and ADP-ribosylation of GTP-binding proteins.
Effects of serotonin on caudal raphe neurons: activation of an inwardly rectifying potassium conductance.
Effects of serotonin on caudal raphe neurons: inhibition of N- and P/Q-type calcium channels and the afterhyperpolarization.
Effects of sodium and GTP on the binding kinetics of [3H]diprenorphine in NG 108-15 cell membranes.
Effects of sodium on agonist efficacy for G-protein activation in mu-opioid receptor-transfected CHO cells and rat thalamus.
Effects of somatostatin on cultured human mesangial cells.
Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus.
Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells.
Effects of spinally and supraspinally injected 3-isobutyl-1-methylxanthine, cholera toxin, and pertussis toxin on cold water swimming stress-induced antinociception in the mouse.
Effects of spinally and supraspinally injected 3-isobutyl-1-methylxanthine, cholera toxin, and pertussis toxin on immobilization stress-induced antinociception in the mouse.
Effects of sulfhydryl-modifying reagents, 3-nitro-2-pyridinesulfenyl compounds, on the coupling between inhibitory receptors and GTP-binding proteins Gi/Go in rat brain membranes.
Effects of synthesized elastin peptides on human leukocytes.
Effects of systemically applied allopurinol and prednisolone on experimental autoimmune uveitis.
Effects of T-588, a novel cognitive enhancer, on ADP-ribosylation of G(s alpha) by cholera toxin and cyclic AMP accumulation in rat cerebral cortex.
Effects of TGF-beta1 on prolactin synthesis and secretion: an in-vitro study.
Effects of the amphiphilic peptides mastoparan and adenoregulin on receptor binding, G proteins, phosphoinositide breakdown, cyclic AMP generation, and calcium influx.
Effects of the amphiphilic peptides melittin and mastoparan on calcium influx, phosphoinositide breakdown and arachidonic acid release in rat pheochromocytoma PC12 cells.
Effects of the nootropic drug nefiracetam on the GABAA receptor-channel complex in dorsal root ganglion neurons.
Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40-41 kDa protein that is ADP ribosylated by pertussis toxin in platelets.
Effects of tiazofurin on guanine nucleotide binding regulatory proteins in HL-60 cells.
Effects of transient oxygen-glucose deprivation on G-proteins and G-protein-coupled receptors in rat CA3 pyramidal cells in vitro.
Effects of triiodothyronine administration on the adenylyl cyclase system in brown adipose tissue of rat.
Effects of tyrosine kinase inhibitors on cell death induced by sodium fluoride and pertussis toxin in the pancreatic beta-cell line, RINm5F.
Effects of UTP on Na+, Cl- and K+ transport in primary cultures from human sweat gland coils.
Effects of zinc on production of active oxygen species by rat neutrophils.
Effects of [(pF)Phe(4)]nociceptin/orphanin FQ-(1-13)NH(2) on GTPgamma(35)S binding and cAMP formation in Chinese hamster ovary cells expressing the human nociceptin/orphanin FQ receptor.
Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice.
Efficacy of chemically cross-linked antigens for acellular pertussis vaccine.
Efficacy of pertussis components in an acellular vaccine, as assessed in a murine model of respiratory infection and a murine intracerebral challenge model.
Efficacy of pertussis vaccines consisted of antigens detoxified with tea-leaf catechins.
Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A.
Efficient production of active and mutated ADP-ribosyltransferase (S1) of pertussis toxin using affinity expression cassette polymerase chain reaction.
EGF inhibits secretagogue-induced cAMP production and amylase secretion by Gi proteins in pancreatic acini.
EGF modulates phosphoinositide levels in ovarian granulosa cells stimulated by luteinizing hormone.
Egg Envelope Glycoproteins ZP1 and ZP3 Mediate Sperm-Egg Interaction in the Japanese Quail.
Eicosanoid production by human aortic endothelial cells in response to endothelin.
Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway.
Elastin peptides activate extracellular signal-regulated kinase 1/2 via a Ras-independent mechanism requiring both p110gamma/Raf-1 and protein kinase A/B-Raf signaling in human skin fibroblasts.
Electrically evoked release of [(3)H]noradrenaline from mouse cultured sympathetic neurons: release-modulating heteroreceptors.
Electrophysiologic responses and adenylate cyclase activities of mouse spinal cord-dorsal root ganglion explants rendered tolerant by chronic exposure to morphine or pertussis toxin.
Electrophysiological effects of alpha 2-adrenergic stimulation in canine cardiac Purkinje fibers.
Electrophysiological evidence for postsynaptic 5-HT(1A) receptor control of dorsal raphe 5-HT neurones.
Elevated axonal membrane permeability and its correlation with motor deficits in an animal model of multiple sclerosis.
Elevated Ca(2+) influx-inducing activity toward mast cells in pretransfusion sera from patients who developed transfusion-related adverse reactions.
Elevated levels of the guanine nucleotide binding protein, Go, are associated with differentiation of neuroblastoma x glioma hybrid cells.
Elevation of intracellular cyclic AMP concentration fails to inhibit adrenaline-induced hyperpolarization in amphibian sympathetic neurons.
Elucidation of linear epitopes of pertussis toxin using overlapping synthetic decapeptides: identification of a human B-cell determinant in the S1 subunit indicative of acute infections.
Emodin accentuates atrial natriuretic peptide secretion in cardiac atria.
Emodin augments calcium activated chloride channel in colonic smooth muscle cells by Gi/Go protein.
Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons.
Endocrine disrupting chemical atrazine causes degranulation through Gq/11 protein-coupled neurosteroid receptor in mast cells.
Endocytosis and retrograde transport of pertussis toxin to the Golgi complex as a prerequisite for cellular intoxication.
Endocytosis and uptake of lucifer yellow by cultured atrial myocytes and isolated intact atria from adult rats. Regulation and subcellular localization.
Endocytosis of CF in marginal cells of stria vascularis regulated by ROCK and MLCK signaling cascade, but not G-proteins.
Endocytosis of Microperoxidase in Marginal Cells Is Mainly Regulated by RhoA Signaling Cascade, but Not by Rho-Associated Protein Kinase, Myosin Light-Chain Kinase and Myosin Phosphatase.
Endogenous ACh tonically stimulates ANP secretion in rat atria.
Endogenous adenosine, A1 adenosine receptor, and pertussis toxin sensitive guanine nucleotide binding protein mediate hypoxia induced AV nodal conduction block in guinea pig heart in vivo.
Endogenous ADP-ribosylation of Gs subunit and autonomous regulation of adenylate cyclase.
Endogenous angiotensin II receptors in Xenopus oocytes and eggs.
Endogenous cannabinoid anandamide directly inhibits voltage-dependent Ca(2+) fluxes in rabbit T-tubule membranes.
Endogenous cannabinoid anandamide inhibits nicotinic acetylcholine receptor function in mouse thalamic synaptosomes.
Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5-HT3 receptor-mediated responses in Xenopus oocytes.
Endogenous delta-opioid and ORL1 receptors couple to phosphorylation and activation of p38 MAPK in NG108-15 cells and this is regulated by protein kinase A and protein kinase C.
Endogenous GABA attenuates CNS white matter dysfunction following anoxia.
Endogenous inhibitor of the ADP-ribosylation of (a) G-protein(s) as catalyzed by pertussis toxin is present in rat liver.
Endogenous modulation of ACh release by somatostatin and the differential roles of Ca2+ channels.
Endogenous opioid receptor-like receptor in human neuroblastoma SK-N-SH cells: activation of inhibitory G protein and homologous desensitization.
Endogenous peptidergic modulation of perisynaptic Schwann cells at the frog neuromuscular junction.
Endogenous platelet-activating factor is critically involved in effector functions of eosinophils stimulated with IL-5 or IgG.
Endogenous prostaglandin E2 and insulin-like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts.
Endogenous regulator of g protein signaling proteins reduce {mu}-opioid receptor desensitization and down-regulation and adenylyl cyclase tolerance in C6 cells.
Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization.
Endogenous regulator of G-protein signaling proteins modify N-type calcium channel modulation in rat sympathetic neurons.
Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model.
Endogenous regulators of G protein signaling proteins regulate presynaptic inhibition at rat hippocampal synapses.
Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.
Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells.
Endogenous somatostatin inhibits histamine release from canine gastric mucosal cells in primary culture.
Endogenous somatostatin receptors mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells.
Endogenous trypsin receptors in Xenopus oocytes: linkage to internal calcium stores.
Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptor.
Endomorphins inhibit high-threshold Ca2+ channel currents in rodent NG108-15 cells overexpressing mu-opioid receptors.
Endomorphins potentiate acid-sensing ion channel currents and enhance the lactic acid-mediated increase in arterial blood pressure: effects amplified in hindlimb ischaemia.
Endorphin suppresses FSH-stimulated proliferation of isolated neonatal Sertoli cells by a pertussis toxin-sensitive mechanism.
Endostatin, the proteolytic fragment of collagen XVIII, induces vasorelaxation.
Endothelial atypical cannabinoid receptor: do we have enough evidence?
Endothelial beta2 adrenergic signaling to AKT: role of Gi and SRC.
Endothelial CD47 Promotes Vascular Endothelial-Cadherin Tyrosine Phosphorylation and Participates in T Cell Recruitment at Sites of Inflammation In Vivo.
Endothelial cell-surface gp60 activates vesicle formation and trafficking via G(i)-coupled Src kinase signaling pathway.
Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway.
Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells.
Endothelial differentiation gene-1, a new downstream gene is involved in RTEF-1 induced angiogenesis in endothelial cells.
Endothelial inositol phosphate generation and prostacyclin production in response to G-protein activation by AlF4-.
Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein.
Endothelial P2-purinoceptors: subtypes and signal transduction.
Endothelin (ET)-1-induced inhibition of ATP release from PC-12 cells is mediated by the ETB receptor: differential response to ET-1 on ATP, neuropeptide Y, and dopamine levels.
Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway.
Endothelin activates large-conductance K+ channels in rat lactotrophs: reversal by long-term exposure to dopamine agonist.
Endothelin activates voltage-dependent Ca2+ current by a G protein-dependent mechanism in rabbit cardiac myocytes.
Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H+ exchanger.
Endothelin B receptor mediates ET-1 effects on cAMP and PGE2 accumulation in rat IMCD.
Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP.
Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway.
Endothelin ET A- and ET B-receptor-mediated inhibition of noradrenaline release from isolated rat stomach.
Endothelin ETA receptor regulates signaling and ANF gene expression via multiple G protein-linked pathways.
Endothelin ETB receptors couple to two distinct signaling pathways in porcine kidney epithelial LLC-PK1 cells.
Endothelin increases the synthesis and secretion of atrial natriuretic peptide in neonatal rat cardiocytes.
Endothelin inhibits adenylate cyclase and stimulates phosphoinositide hydrolysis in adult cardiac myocytes.
Endothelin inhibits vasopressin-stimulated water permeability in rat terminal inner medullary collecting duct.
Endothelin mobilizes Ca2+ from a caffeine- and ryanodine-insensitive intracellular pool in rat atrial cells.
Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells.
Endothelin receptor binding and cellular signal transduction in neurohybrid NG108-15 cells.
Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells.
Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells.
Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature.
Endothelin receptor type A signals both the accumulation of inositol phosphates and the inhibition of cyclic AMP generation in rat myometrium: stimulation and desensitization.
Endothelin receptors and coupled GTP-binding proteins in glomerular mesangial cells.
Endothelin receptors and their cellular signal transduction mechanism in human cultured prostatic smooth muscle cells.
Endothelin receptors in rat cerebellum: activation of phosphoinositide hydrolysis is transduced by multiple G-proteins.
Endothelin stimulates 86Rb efflux in rat glioma C6-Bu-1 cells.
Endothelin stimulates multiple responses in isolated adult ventricular cardiac myocytes.
Endothelin stimulates phospholipase D in striatal astrocytes.
Endothelin stimulates platelet-activating factor synthesis by cultured rat Kupffer cells.
Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells.
Endothelin- and ATP-induced inhibition of adenylyl cyclase activity in C6 glioma cells: role of Gi and calcium.
Endothelin- and sarafotoxin-induced phosphoinositide hydrolysis in cultured canine tracheal smooth muscle cells.
Endothelin- and sarafotoxin-induced phosphoinositide hydrolysis in cultured cerebellar granule cells: biochemical and pharmacological characterization.
Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt.
Endothelin-1 activates mitogen-activated protein kinases through two independent signalling pathways in rat astrocytes.
Endothelin-1 activates p38 mitogen-activated protein kinase and cytosolic phospholipase A2 in cat iris sphincter smooth muscle cells.
Endothelin-1 and insulin activate the steady-state voltage dependent R-type Ca2+ channel in aortic smooth muscle cells via a pertussis toxin and cholera toxin sensitive G-protein.
Endothelin-1 decreases glutamate uptake in primary cultured rat astrocytes.
Endothelin-1 increases glucose transporter glut1 mRNA accumulation in 3T3-L1 adipocytes by a mitogen-activated protein kinase-dependent pathway.
Endothelin-1 induces p66Shc activation through EGF receptor transactivation: Role of beta(1)Pix/Galpha(i3) interaction.
Endothelin-1 inhibition of cardiac ATP-sensitive K+ channels via pertussis-toxin-sensitive G-proteins.
Endothelin-1 inhibits L-type Ca currents enhanced by isoproterenol in guinea-pig ventricular myocytes.
Endothelin-1 inhibits the slow component of cardiac delayed rectifier K+ currents via a pertussis toxin-sensitive mechanism.
Endothelin-1 is synthesized and inhibits cyclic adenosine monophosphate- dependent anion secretion by an autocrine/paracrine mechanism in gallbladder epithelial cells.
Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells.
Endothelin-1 partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells.
Endothelin-1 receptor binding and cellular signal transduction in cultured human brain endothelial cells.
Endothelin-1 receptors on cultured rat articular chondrocytes: regulation by age, growth factors, and cytokines, and effect on cAMP production.
Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells.
Endothelin-1 stimulates the release of arachidonic acid and prostaglandins in cultured human ciliary muscle cells: activation of phospholipase A2.
Endothelin-1 stimulates the release of preloaded [3H]D-aspartate from cultured cerebellar granule cells.
Endothelin-1 suppression of rat adipocyte precursor cell differentiation in serum-free culture.
Endothelin-1 Upregulates Activin Receptor-Like Kinase-1 Expression via Gi/RhoA/Sp-1/Rho Kinase Pathways in Human Pulmonary Arterial Endothelial Cells.
Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors.
Endothelin-3 activates a voltage-gated Ca channel via a pertussis toxin sensitive mechanism leading to dopamine release from PC12 cells.
Endothelin-3 stimulates production of endothelium-derived nitric oxide via phosphoinositide breakdown.
Endothelin-dependent actions in cultured AT-1 cardiac myocytes. The role of the epsilon isoform of protein kinase C.
Endothelin-elicited stimulation of phospholipase C is mediated by guanine nucleotide binding protein(s).
Endothelin-evoked Release of Arachidonic Acid from Mouse Astrocytes in Primary Culture.
Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types.
Endothelin-induced cytoskeletal actin re-organization in cultured astrocytes: inhibition by C3 ADP-ribosyltransferase.
Endothelin-induced increases in vascular smooth muscle Ca2+ do not depend on dihydropyridine-sensitive Ca2+ channels.
Endothelin-induced inositol phosphate formation in rat kidney. Studies on receptor subtypes, G-proteins and regulation during ontogenesis.
Endothelin-induced protein tyrosine phosphorylation of cultured astrocytes: its relationship to cytoskeletal actin organization.
Endothelin-mediated vascular growth requires p42/p44 mitogen-activated protein kinase and p70 S6 kinase cascades via transactivation of epidermal growth factor receptor.
EndothelinB receptor activation enhances parathyroid hormone-induced calcium signals in UMR-106 cells.
Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components.
Endothelins inhibit adenylate cyclase in brain capillary endothelial cells.
Endothelins stimulate cyclic AMP accumulation in the isolated rat anterior pituitary gland: possible involvement of ETA receptor activation and prostaglandin E2 production.
Endothelins stimulate tyrosine phosphorylation and activity of p42/mitogen-activated protein kinase in astrocytes.
Endothelium-dependent inhibition of ergonovine-induced contraction is impaired in porcine coronary arteries with regenerated endothelium.
Endothelium-derived hyperpolarizing factor mediated relaxations in pig coronary arteries do not involve Gi/o proteins.
Endotoxin activation of mitogen-activated protein kinase in THP-1 cells; diminished activation following endotoxin desensitization.
Endotoxin tolerance impairs a pertussis-toxin-sensitive G-protein regulating tumour necrosis factor release by macrophages from tumour-bearing rats.
Endotoxin tolerance is associated with altered GTP-binding protein function.
Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction.
Endotoxins in cholera and pertussis toxins interfere with in vivo responses to these agents in the albino rabbit eye.
Engagement of CD47 inhibits the contact hypersensitivity response via the suppression of motility and B7 expression by Langerhans cells.
Engineering bacterial toxin for the development of new vaccine against pertussis.
Engineering of an Iranian Bordetella pertussis strain producing inactive pertussis toxin.
Engineering of genetically detoxified pertussis toxin analogs for development of a recombinant whooping cough vaccine.
Enhanced
Enhanced adhesive capacities of the naturally occurring Ile249-Met280 variant of the chemokine receptor CX3CR1.
Enhanced alpha 1-adrenergic responsiveness in cardiomyopathic hamster cardiac myocytes. Relation to the expression of pertussis toxin-sensitive G protein and alpha 1-adrenergic receptors.
Enhanced cAMP accumulation after termination of cholinergic action in the heart.
Enhanced cAMP response of naturally occurring mutant of human beta3-adrenergic receptor.
Enhanced cardiac L-type calcium current response to beta2-adrenergic stimulation in heart failure.
Enhanced cyclic AMP responses in GH3 pituitary cells pretreated with muscarinic receptor agonists.
Enhanced epinephrine-induced platelet aggregation in individuals carrying the G protein beta3 subunit 825T allele.
Enhanced expression of Gi? proteins contributes to the hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats via MAP kinase- and PI3 kinase-independent pathways.
Enhanced expression of GTP-binding proteins in differentiated U937 monocytic cells: possible involvement of tyrosine kinase and protein kinase C.
Enhanced expression of inhibitory guanine nucleotide regulatory protein in spontaneously hypertensive rats. Relationship to adenylate cyclase inhibition.
Enhanced fMLP-stimulated chemotaxis in human neutrophils from individuals carrying the G protein beta3 subunit 825 T-allele.
Enhanced G protein activation in IDDM patients with diabetic nephropathy.
Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension.
Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts.
Enhanced G-protein-induced relaxation in portal hypertensive rats: role of nitric oxide.
Enhanced GABA(B) receptor in neoplastic rat liver: induction of DNA synthesis by baclofen in hepatocyte cultures.
Enhanced Gi-protein-mediated mitogenesis following chronic ethanol exposure in a rat model of experimental hepatocellular carcinoma.
Enhanced HIV-1 replication by chemokines constitutively expressed in secondary lymphoid tissues.
Enhanced immune response against pertussis toxoid by IgA-loaded chitosan-dextran sulfate nanoparticles.
Enhanced inhibition of L-type Ca2+ current by beta3-adrenergic stimulation in failing rat heart.
Enhanced interaction between renovascular alpha(2)-adrenoceptors and angiotensin II receptors in genetic hypertension.
Enhanced IPC by activation of pertussis toxin-sensitive and -insensitive G protein-coupled purinoceptors.
Enhanced negative chronotropy by inhibitory receptors in transgenic heart overexpressing beta(2)-adrenoceptors.
Enhanced negative inotropic effect of an adenosine A1-receptor agonist in rat left atria in hypothyroidism.
Enhanced post-licensure safety surveillance of a new recombinant acellular pertussis vaccine licensed as a monovalent (aP, Pertagen®) and tetanus, reduced-dose diphtheria combination (TdaP, Boostagen®) vaccine for immunization of adolescents and adults in Thailand.
Enhanced sensitisation of mice with diphtheria tetanus acellular pertussis vaccine to local swelling reaction to the booster immunisation.
Enhanced type 1alpha metabotropic glutamate receptor-stimulated phosphoinositide signaling after pertussis toxin treatment.
Enhanced vascular reactivity to mastoparan, a G protein activator, in genetically hypertensive rats.
Enhancement by baclofen of the Gs-coupled receptor-mediated cAMP production in Xenopus oocytes expressing rat brain cortex poly (A)+ RNA: a role of G-protein beta gamma subunits.
Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase.
Enhancement in beta-adrenergic responsiveness of adenylate cyclase in rat liver during regeneration after carbon tetrachloride administration.
Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Withdrawal of GTP-dependent inhibition.
Enhancement of adenylate cyclase stimulation by prostaglandin E receptor EP3 subtype isoforms with different efficiencies.
Enhancement of an L-type calcium current in AtT-20 cells; a novel effect of the m4 muscarinic receptor.
Enhancement of ATP-sensitive potassium current in cat ventricular myocytes by beta-adrenoreceptor stimulation.
Enhancement of bradykinin-induced prostacyclin synthesis in porcine aortic endothelial cells by pertussis toxin. Possible implication of lipocortin I.
Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cells.
Enhancement of delayed rectifier K+ current by P2-purinoceptor stimulation in guinea-pig atrial cells.
Enhancement of differentiation of cultured adipogenic cells (TA1) by pertussis toxin.
Enhancement of differentiation of rat adipocyte precursor cells by pertussis toxin.
Enhancement of histamine-induced vascular leakage by pertussis toxin in SJL/J mice but not BALB/c mice.
Enhancement of HIV-1 replication in human macrophages is induced by CD8+ T cell soluble factors.
Enhancement of interleukin-4 production by pertussis toxin.
Enhancement of lysophosphatidic acid-induced ERK phosphorylation by phospholipase D1 via the formation of phosphatidic acid.
Enhancement of neuronal calcium channel currents by the nootropic agent, nefiracetam (DM-9384), in NG108-15 cells.
Enhancement of parathyroid hormone-responsive renal cortical adenylate cyclase activity by a cytosol protein activator from rat reticulocytes.
Enhancement of stress-induced synthesis of stress proteins by mastoparan in C6 rat glioma cells.
Enhancement of Th1 Lung Immunity Induced by Recombinant Mycobacterium bovis BCG Attenuates Airway Allergic Disease.
Enhancement of the locomotor response to apomorphine in pertussis toxin-treated animals depends on the site of pertussis toxin injection into the ventral tegmental area.
Enhancement of the migration of metastatic human breast cancer cells by phosphatidic acid.
Enhancement of the positive inotropic effect mediated by alpha 1-adrenoceptors in pertussis toxin-treated rabbit papillary muscles.
Enhancing effects of pertussis toxin B oligomer on the immunogenicity of influenza vaccine administered intranasally.
Enkephalin activates the phospholipase C/Ca2+ system through cross-talk between opioid receptors and P2-purinergic or bradykinin receptors in NG 108-15 cells. A permissive role for pertussis toxin-sensitive G-proteins.
Enkephalin induces Ca2+ mobilization in single cells of bradykinin-sensitized differentiated neuroblastoma hybridoma (NG108-15) cells.
Entamoeba invadens contains the components of a classical adrenergic signaling system.
Enteric glia exhibit P2U receptors that increase cytosolic calcium by a phospholipase C-dependent mechanism.
Entrapping of impermeant probes of different size into nonpermeabilized synaptosomes as a method to study presynaptic mechanisms.
Environmental regulation of expression of virulence determinants in Bordetella pertussis.
Enzymatic and immunological detection of G protein alpha-subunits in the pathogenic fungus Candida albicans.
Enzymatic and nonenzymatic ADP-ribosylation of cysteine.
Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages.
Enzyme-linked immunosorbent assay for detecting anti-pertussis toxin antibody in mouse.
Eosinophil activation by eotaxin--eotaxin primes the production of reactive oxygen species from eosinophils.
Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo.
Eosinophil leukocyte degranulation in response to serum-opsonized beads: C5a and platelet-activating factor enhance ECP release, with roles for protein kinases A and C.
Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway.
Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells.
Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode Strongyloides stercoralis.
Eotaxin influences the development of embryonic hematopoietic progenitors in the mouse.
Eotaxin modulates myelopoiesis and mast cell development from embryonic hematopoietic progenitors.
Eotaxin-2 activates chemotaxis-related events and release of reactive oxygen species via pertussis toxin-sensitive G proteins in human eosinophils.
Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes.
Eotaxin/CCL11 suppresses IL-8/CXCL8 secretion from human dermal microvascular endothelial cells.
EP receptor-mediated inhibition by prostaglandin E(1) of cardiac L-type Ca(2+) current of rabbits.
EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein.
EP1 Prostanoid Receptor Coupling to Gi/o Upregulates the Expression of Hypoxia-Inducible Factor-1{alpha} Through Activation of a Phosphoinositide-3 Kinase Signaling Pathway.
EP2 receptor activates dual G protein signaling pathways that mediate contrasting proinflammatory and relaxatory responses in term pregnant human myometrium.
EP3 Receptor Isoforms are Differentially Expressed in Subpopulations of Primate Granulosa Cells and Couple to Unique G-Proteins.
Epidermal growth factor activates phospholipase C in rat hepatocytes via a different mechanism from that in A431 or rat1hER cells.
Epidermal growth factor activates phospholipase C-gamma 1 via G(i)1-2 proteins in isolated pancreatic acinar membranes.
Epidermal growth factor activation of rat parotid gland adenylate cyclase and mediation by a GTP-binding regulatory protein.
Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate.
Epidermal growth factor and transforming growth factor alpha stimulate or inhibit proliferation of a human renal adenocarcinoma cell line depending on cell status: differentiation of the two pathways by G protein involvement.
Epidermal growth factor differentially augments G(i)-mediated stimulation of c-Jun N-terminal kinase activity.
Epidermal growth factor enhances glomerular mesangial cell soluble phospholipase A2 activity.
EPIDERMAL GROWTH FACTOR INCREASES LYSOPHOSPHATIDIC ACID PRODUCTION IN HUMAN OVARIAN CANCER CELLS: ROLES FOR PHOSPHOLIPASE D2 AND RECEPTOR TRANSACTIVATION.
Epidermal growth factor inhibits bombesin-induced activation of phospholipase C-beta1 in rat pancreatic acinar cells.
Epidermal growth factor receptor transactivation mediates substance P-induced mitogenic responses in U-373 MG cells.
Epidermal growth factor stimulates hydrolysis of phosphatidylinositol 4,5-bisphosphate, generation of diacylglycerol and exocytosis in mouse spermatozoa.
Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells.
Epidermal growth factor-induced activation and translocation of phospholipase C-gamma 1 to the cytoskeleton in rat hepatocytes.
Epidermal growth factor-induced phosphoinositide hydrolysis in permeabilized 3T3 cells: lack of guanosine triphosphate dependence and inhibition by tyrosine-containing peptides.
Epidermal growth factor-mediated signaling of G(i)-protein to activation of phospholipases in rat-cultured hepatocytes.
Epidermal growth factor-stimulated phosphoinositide hydrolysis in cultured rat inner medullary collecting tubule cells. Regulation by G protein, calcium, and protein kinase C.
Epidermal micro-perforation potentiates the efficacy of epicutaneous vaccination.
Epidermal-growth-factor-induced formation of inositol phosphates in human A431 cells. Differences from the effect of bradykinin.
Epigenetic activation of Gi-2 protein, the product of a putative protooncogene, mediates tumor promotion in vitro.
Epileptogenesis reduces the sensitivity of presynaptic gamma-aminobutyric acidB receptors on glutamatergic afferents in the amygdala.
Epinephrine activates both Gs and Gi pathways, but norepinephrine activates only the Gs pathway through human beta2-adrenoceptors overexpressed in mouse heart.
Epinephrine impairs insulin release by a mechanism distal to calcium mobilization. Similarity to lipoxygenase inhibitors.
Epinephrine induces changes in the subcellular distribution of the inhibitory GTP-binding protein Gi alpha-2 and a 38-kDa phosphorylated protein in the human platelet.
Epinephrine-induced hyperpolarization of islet cells without KATP channels.
Epithelial anion transporter pendrin contributes to inflammatory lung pathology in mouse models of Bordetella pertussis infection.
Epithelial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway.
Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGFbeta signal transduction mechanisms.
Epitope specificity of three anti-pertussis toxin monoclonal antibodies with dissimilar effects in assays of toxin neutralizing activity.
Epitopes on the S1 subunit of pertussis toxin recognized by monoclonal antibodies.
Epoxyeicosatrienoic acid stimulates ADP-ribosylation of a 52 kDa protein in rat liver cytosol.
Epstein-Barr Virus Induced Gene 2 (EBI2) Mediates Allergen-induced, Leukocyte Migration into Airways.
Equol-Stimulated Mitochondrial Reactive Oxygen Species Activate Endothelial Nitric Oxide Synthase and Redox Signaling in Endothelial Cells: Roles for F-Actin and GPR30.
ER-resident G(i2) protein controls Sar1 translocation onto the ER during budding of transport vesicles.
Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptors.
ERK2 mediates oxytocin-stimulated PGE2 synthesis.
Essential role for extracellular Ca(2+) in JNK activation by mechanical stretch in bladder smooth muscle cells.
Essential role for G proteins in prostate cancer cell growth and signaling.
Essential role of EP3 subtype in prostaglandin E2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix.
Essential role of G protein-gated inwardly rectifying potassium channels in gonadotropin-induced regulation of GnRH neuronal firing and pulsatile neurosecretion.
Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis.
Essential role of the consensus nucleotide-binding site of PtlH in secretion of pertussis toxin from Bordetella pertussis.
Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury.
Establishment and application of a multiple cross displacement amplification combined with nanoparticles-based biosensor method for the detection of Bordetella pertussis.
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
Establishment of diagnostic cutoff points for levels of serum antibodies to pertussis toxin, filamentous hemagglutinin, and fimbriae in adolescents and adults in the United States.
Establishment of Pertussis toxin BRP batch 2 for CHO clustering assay.
Estimated and reported incidence of pertussis in Estonian adults: A seroepidemiological study.
Estimating Bordetella pertussis seroprevalence in adolescents and young adults in Mexico using the 2012 National Health and Nutrition Survey (ENSANUT).
Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15.
Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism.
Estradiol increases cyclic adenosine monophosphate in rat pulmonary vascular smooth muscle cells by a nongenomic mechanism.
Estradiol signaling via sequestrable surface receptors.
Estradiol up-regulates the stimulatory GTP-binding protein expression in the MCF-7 human mammary carcinoma cell line.
Estradiol-stimulated increases in uterine eosinophils and nuclear type II estrogen-binding sites are prevented by pertussis toxin.
Estrogen inhibits D2S receptor-regulated Gi3 and Gs protein interactions to stimulate prolactin production and cell proliferation in lactotropic cells.
Estrogen mediated inhibition of dopamine transport in the striatum: regulation by G alpha i/o.
Estrogen modulates in vitro atrial bradycardia induced by Indian red scorpion venom via G-protein coupled mechanisms.
Estrogen Receptor Activation Protects Against TNF-?-Induced Endothelial Dysfunction.
Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors.
Estrogen uncouples beta-adrenergic receptor from the stimulatory guanine nucleotide-binding protein in female rat hypothalamus.
Estrogens promote human testicular germ cell cancer through a membrane-mediated activation of extracellular regulated kinase and protein kinase A.
ET-1 cooperates with EGF to induce mitogenesis via a PTX-sensitive pathway in airway smooth muscle cells.
ET-1 induced Elevation of intracellular calcium in clonal neuronal and embryonic kidney cells involves endogenous endothelin-A receptors linked to phospholipase C through G?(q/11).
ET-1 stimulates Ca2+ currents in cardiac cells.
ET-1 stimulates ERK signaling pathway through sequential activation of PKC and Src in rat myometrial cells.
ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species.
ET-1-associated vasomotion and vasospasm in lymphatic vessels of the guinea-pig mesentery.
ETA and ETB receptors cooperate in DNA synthesis via opposing regulations of cAMP in human lung cell line.
Ethanol acts synergistically with a D2 dopamine agonist to cause translocation of protein kinase C.
Ethanol alters angiotensin II stimulated mitogen activated protein kinase in hepatocytes: agonist selectivity and ethanol metabolic independence.
Ethanol differentially increases alpha 2-adrenergic and muscarinic acetylcholine receptor gene expression in NG108-15 cells.
Ethanol enhances basal and flow-stimulated nitric oxide synthase activity in vitro by activating an inhibitory guanine nucleotide binding protein.
Ethanol extract of Glycyrrhizae Radix modulates the responses of antigen-specific splenocytes in experimental autoimmune encephalomyelitis.
Ethanol inhibits zymosan-stimulated eicosanoid production in mouse peritoneal macrophages.
Ethanol triggers neural crest apoptosis through the selective activation of a pertussis toxin-sensitive G protein and a phospholipase Cbeta-dependent Ca2+ transient.
Etorphine elicits anomalous excitatory opioid effects on sensory neurons treated with GM1 ganglioside or pertussis toxin in contrast to its potent inhibitory effects on naive or chronic morphine-treated cells.
Etorphine inhibits cell growth and induces apoptosis in SK-N-SH cells: involvement of pertussis toxin-sensitive G proteins.
Eukaryotic mono(ADP-ribosyl)transferase that ADP-ribosylates GTP-binding regulatory Gi protein.
European Sero-Epidemiology Network 2: standardisation of immunoassay results for pertussis requires homogeneity in the antigenic preparations.
European Sero-Epidemiology Network: standardisation of the assay results for pertussis.
EUVAC.NET collaborative study: Evaluation and standardisation of serology for diagnosis of pertussis.
Evading the proteasome: absence of lysine residues contributes to pertussis toxin activity by evasion of proteasome degradation.
Evaluation of a commercial loop-mediated isothermal amplification assay for diagnosis of Bordetella pertussis infection.
Evaluation of a guinea pig model to assess interference in the immunogenicity of different components of a combination vaccine comprising diphtheria, tetanus and acellular pertussis (DTaP) vaccine and haemophilus influenzae type b capsular polysaccharide conjugate vaccine.
Evaluation of a multitarget real-time PCR assay for detection of Bordetella species during a pertussis outbreak in New Hampshire in 2011.
Evaluation of a single-sample serological technique for diagnosing pertussis in unvaccinated children.
Evaluation of a tetraplex microsphere assay for Bordetella pertussis antibodies.
Evaluation of activation of G proteins in response to thyroid stimulating hormone in thyroid gland cells from euthyroid and hyperthyroid cats.
Evaluation of an immunoglobulin G enzyme-linked immunosorbent assay for pertussis toxin and filamentous hemagglutinin in diagnosis of pertussis in Senegal.
Evaluation of Anti-PT Antibody Response after Pertussis Vaccination and Infection: The Importance of Both Quantity and Quality.
Evaluation of antibodies elicited by immunization with pertussis toxin.
Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release.
Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection.
Evaluation of experimental autoimmune uveitis in mice treated with FTY720.
Evaluation of IL-17 Serum Level, Brain Inflammation and Demyelination in Experimental Autoimmune Encephalomyelitis C57BL/6 Mice Model with Different Doses of Myelin Oligodendrocyte Glycoprotein.
Evaluation of inactivated Bordetella pertussis as a delivery system for the immunization of mice with Pneumococcal Surface Antigen A.
Evaluation of novel cyclic analogues of apelin.
Evaluation of PCR for diagnosis of Bordetella pertussis and Bordetella parapertussis infections.
Evaluation of pertussis in U.S. Marine Corps trainees.
Evaluation of Pertussis Toxin Expression in B2 and THIJS Media.
Evaluation of pooled and individual components of Bordetella pertussis as antigens in an enzyme immunoassay for diagnosis of pertussis.
Evaluation of real-time PCR for diagnosis of Bordetella pertussis infection.
Evaluation of serologic assays for diagnosis of whooping cough.
Evaluation of serology and nasopharyngeal cultures for diagnosis of pertussis in a vaccine efficacy trial.
Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells.
Evaluation of the role of second messenger systems in tumor necrosis factor-stimulated resorption of fetal rat limb bones.
Evaluation of two serological methods for potency testing of whole cell pertussis vaccines.
Evidence against a role for a pertussis toxin-sensitive G protein in Ca2+ mobilization in rat parotid acinar cells.
Evidence against a role of a pertussis toxin-sensitive guanine nucleotide-binding protein in the alpha 1-adrenoceptor-mediated positive inotropic effect in the heart.
Evidence against roles for pertussis toxin sensitive G proteins or diacylglycerol generation in insulin-like growth factor-1 stimulated DNA synthesis in MG-63 osteosarcoma cells.
Evidence for a beta2-adrenergic/arachidonic acid pathway in ventricular cardiomyocytes. Regulation by the beta1-adrenergic/camp pathway.
Evidence for a catalytic role of glutamic acid 129 in the NAD-glycohydrolase activity of the pertussis toxin S1 subunit.
Evidence for a cyclic AMP-dependent pathway in angiotensin AT1-receptor activation of human omental arteries.
Evidence for a direct negative coupling between dopamine-D2 receptors and PLC by heterotrimeric Gi1/2 proteins in rat anterior pituitary cell membranes.
Evidence for a discrete UTP receptor in cardiac endothelial cells.
Evidence for a dual control of macroautophagic sequestration and intracellular trafficking of N-linked glycoproteins by the trimeric G(i3) protein in HT-29 cells.
Evidence for a functionally active inhibitory guanine nucleotide-binding regulatory protein in the swine ovary.
Evidence for a GTP-binding protein involved in interferon-gamma transduction signal.
Evidence for a ninth gene, ptlI, in the locus encoding the pertussis toxin secretion system of Bordetella pertussis and formation of a PtlI-PtlF complex.
Evidence for a pertussis toxin sensitive calcium entry pathway in thyroid FRTL-5 cells.
Evidence for a pertussis toxin-sensitive G protein involved in the control of meiotic reinitiation of Xenopus laevis oocytes.
Evidence for a pertussis toxin-sensitive signalling pathway in the dual action of angiotensin II on growth hormone release in pituitary cell aggregates.
Evidence for a role of G protein beta gamma subunits in the enhancement of cAMP accumulation and DNA synthesis by adenosine in human cells.
Evidence for a Role of Opioids in Epoxyeicosatrienoic Acid (EET)-induced Cardioprotection in Rat Hearts.
Evidence for an intracellular niche for Bordetella pertussis in broncho-alveolar lavage cells of mice.
Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes.
Evidence for cocaine and methylecgonidine stimulation of M(2) muscarinic receptors in cultured human embryonic lung cells.
Evidence for coupling of bradykinin receptors to a guanine-nucleotide binding protein to stimulate arachidonate liberation in the osteoblast-like cell line, MC3T3-E1.
Evidence for cross-talk between M2 and M3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal-regulated kinase signalling pathways in Chinese hamster ovary cells.
Evidence for deactivation of both ectosolic and cytosolic 5'-nucleotidase by adenosine A1 receptor activation in the rat cardiomyocytes.
Evidence for expression of a Ras-like and a stage specific GTP binding homologous protein by Plasmodium falciparum.
Evidence for G beta gamma-mediated cross-talk in primary cultures of lung alveolar cells. Pertussis toxin-sensitive production of cAMP.
Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons.
Evidence for G protein modulation of experimental-generalized absence seizures in rat.
Evidence for G proteins in rat parotid plasma membranes and secretory granule membranes.
Evidence for G-Protein Regulation of Inward K+ Channel Current in Guard Cells of Fava Bean.
Evidence for guanosine triphosphate--binding proteins in Trypanosoma cruzi.
Evidence for inhibition by protein kinase A of receptor/G alpha(q)/phospholipase C (PLC) coupling by a mechanism not involving PLCbeta2.
Evidence for involvement of a GTP-binding protein in activation of Ca2+ influx by epidermal growth factor in A431 cells: effects of fluoride and bacterial toxins.
Evidence for involvement of guanine nucleotide-binding regulatory proteins in the activation of phospholipases by hormones.
Evidence for kinetic disparity among pertussis toxin substrate G-proteins coupled to opiate receptors.
Evidence for m2 and m3 muscarinic receptor involvement in cholinergic excitatory junction potentials through synergistic activation of cation channels in the longitudinal muscle of mouse ileum.
Evidence for paracrine modulation of voltage-dependent calcium channels by amperometric analysis in cultured porcine adrenal chromaffin cells.
Evidence for paracrine signaling between macrophages and bovine adrenal chromaffin cell Ca(2+) channels.
Evidence for participation of calcineurin in potentiation of agonist-stimulated cyclic AMP formation by the calcium-mobilizing hormone, angiotensin II.
Evidence for pharmacologically distinct subsets of GABAB receptors.
Evidence for PI3K-dependent CXCR3 agonist-induced degranulation of human cord blood-derived mast cells.
Evidence for pleiotropic signaling at the mouse beta3-adrenoceptor revealed by SR59230A [3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate].
Evidence for receptor-mediated inhibition of intrinsic activity of GTP-binding protein, Gi1 and Gi2, but not G0 in reconstitution experiments.
Evidence for the dual coupling of the rat neurotensin receptor with pertussis toxin-sensitive and insensitive G-proteins.
Evidence for the implication of phosphoinositol signal transduction in mu-opioid inhibition of DNA synthesis.
Evidence for the inhibitory subunit of adenylate cyclase (Ni) in nervous and heart tissue of Aplysia.
Evidence for the interaction of mast cell-degranulating peptide with pertussis toxin-sensitive G proteins in mast cells.
Evidence for the involvement of a pertussis toxin-insensitive G-protein in egg activation of the frog, Xenopus laevis.
Evidence for the involvement of Gi2 in activation of extracellular signal-regulated kinases in hepatocytes.
Evidence for the involvement of multiple signalling pathways in C5a-induced actin polymerization and nucleation in human monocyte-like cells.
Evidence for the presence of cholinergic muscarinic receptors negatively linked to adenylate cyclase in the iris-ciliary body.
Evidence for the presence of G-proteins, adenylyl cyclase and phospholipase C activities in lymphatic smooth muscle cell membranes.
Evidence for the presence of P2-purinoceptors at the surface of human articular chondrocytes in monolayer culture.
Evidence for the presence of serotonin receptors negatively coupled to adenylate cyclase in the rabbit iris-ciliary body.
Evidence for the role of heterotrimeric guanine nucleotide-binding regulatory proteins in the regulation of the mouse sperm adenylyl cyclase by the egg's zona pellucida.
Evidence for tight coupling of Gi protein-mediated lysophosphatidic acid receptor to stimulated cytokine production in ovarian cancer cell.
Evidence for transduction of mu but not kappa opioid modulation of extracellular signal-regulated kinase activity by G(z) and G(12) proteins.
Evidence for two atypical conformations of beta-adrenoceptors and their interaction with Gi proteins.
Evidence for two different stimulatory adenylate cyclase coupling mechanisms in rat renal papilla.
Evidence for two GTPases activated by thrombin in membranes of human platelets.
Evidence from studies with hepatocyte suspensions that store-operated Ca2+ inflow requires a pertussis toxin-sensitive trimeric G-protein.
Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children.
Evidence of endogenous mono-ADP-ribosylation of cardiac proteins via anti-ADP-ribosylarginine immunoreactivity.
Evidence of heterotrimeric G-protein involvement in regulated exocytosis from permeabilized pancreatic acini.
Evidence of increased circulation of Bordetella pertussis in the Italian adult population from seroprevalence data (2012-2013).
Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the G?q protein-coupled and PI3K signaling pathways.
Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate.
Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor.
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.
Evidence that a guanine nucleotide-binding protein linked to a muscarinic receptor inhibits directly phospholipase C.
Evidence that a pertussis-toxin-sensitive substrate is involved in the stimulation by epidermal growth factor and vasopressin of plasma-membrane Ca2+ inflow in hepatocytes.
Evidence that a receptor-operated event on the neutrophil mediates neutrophil accumulation in vivo. Pretreatment of 111In-neutrophils with pertussis toxin in vitro inhibits their accumulation in vivo.
Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms.
Evidence that angiotensin II and lipoxygenase products activate c-Jun NH2-terminal kinase.
Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors.
Evidence that Arg-295, Glu-378, and Glu-380 are active-site residues of the ADP-ribosyltransferase activity of iota toxin.
Evidence that conditionally immortalized human osteoblasts express an osteocalcin receptor.
Evidence that G(z)-proteins couple to hypothalamic 5-HT(1A) receptors in vivo.
Evidence that guanosine triphosphate (GTP)-binding proteins control a synaptic response in brain: effect of pertussis toxin and GTP gamma S on the late inhibitory postsynaptic potential of hippocampal CA3 neurons.
Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism.
Evidence that lipopolysaccharide and pertussis toxin bind to different domains on the same p73 receptor on murine splenocytes.
Evidence that M3 muscarinic receptors in rat parotid gland couple to two second messenger systems.
Evidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems.
Evidence that myocardial pertussis toxin substrates are uniquely altered in acute murine Chagas' disease in a manner unrelated to myocardial dysfunction.
Evidence that receptor-linked G protein inhibits exocytosis by a post-second-messenger mechanism in AtT-20 cells.
Evidence that separate PGE2 receptors modulate water and sodium transport in rabbit cortical collecting duct.
Evidence that the action of calcitonin on rat osteoclasts is mediated by two G proteins acting via separate post-receptor pathways.
Evidence that the appressorial development in barley powdery mildew is controlled by MAP kinase activity in conjunction with the cAMP pathway.
Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A2.
Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways.
Evidence that the substance P-induced enhancement of pacemaking in lymphatics of the guinea-pig mesentery occurs through endothelial release of thromboxane A2.
Evidence that thrombin-stimulated DNA synthesis in pulmonary arterial fibroblasts involves phosphatidylinositol 3-kinase-dependent p70 ribosomal S6 kinase activation.
Evidence that thyrotropin-releasing hormone-induced increases in GTPase activity and phosphoinositide metabolism in GH3 cells are mediated by a guanine nucleotide-binding protein other than Gs or Gi.
Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells.
Evidence that v-Src-induced phospholipase D activity is mediated by a G protein.
Evolution of Bordetella pertussis over a 23-year period in France, 1996 to 2018.
Evolutionary relationships in the genus Bordetella.
Evolutionary trees for the genus Bordetella.
Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins.
Examination of the signal transduction pathways leading to activation of extracellular signal-regulated kinase by formyl-methionyl-leucyl-phenylalanine in rat neutrophils.
Excitation of locus coeruleus neurons by vasoactive intestinal peptide: evidence for a G-protein-mediated inward current.
Excitatory amino acid receptor-stimulated phosphoinositide turnover in primary cerebrocortical cultures.
Excitatory amino acids inhibit stimulated phosphoinositide hydrolysis in the rat prefrontal cortex.
Existence of GPR40 functioning in a human breast cancer cell line, MCF-7.
Exocytosis from permeabilized bovine adrenal chromaffin cells is differently modulated by guanosine 5'-[gamma-thio]triphosphate and guanosine 5'-[beta gamma-imido]triphosphate. Evidence for the involvement of various guanine nucleotide-binding proteins.
Exocytosis in chromaffin cells: evidence for a MgATP-independent step that requires a pertussis toxin-sensitive GTP-binding protein.
Exocytosis in electropermeabilized neutrophils. Responsiveness to calcium and guanosine 5'-[gamma-thio]triphosphate.
Exocytosis in mast cells by basic secretagogues: evidence for direct activation of GTP-binding proteins.
Exocytotic enzyme release from rabbit polymorphonuclear leukocytes after treatment with fluoride and calcium.
Exotoxin-insensitive G proteins mediate synaptically evoked muscarinic sodium current in rabbit sympathetic neurones.
Experience with monocomponent acellular pertussis combination vaccines for infants, children, adolescents and adults-A review of safety, immunogenicity, efficacy and effectiveness studies and 15 years of field experience.
Experimental allergic neuritis in the SJL/J mouse: induction of severe and reproducible disease with bovine peripheral nerve myelin and pertussis toxin with or without interleukin-12.
Experimental and clinical aspects of melatonin and clock genes in diabetes.
Experimental arthritis and uveitis in rats associated with Mycobacterium butyricum.
Experimental autoimmune anterior uveitis (EAAU). II. Dose-dependent induction and adoptive transfer using a melanin-bound antigen of the retinal pigment epithelium.
Experimental autoimmune anterior uveitis. Induction with melanin-associated antigen from the iris and ciliary body.
Experimental autoimmune anterior uveitis. The preparation of uveitogenic ocular melanin.
Experimental autoimmune encephalomyelitis (EAE) induced by antigen pulsed dendritic cells in the C57BL/6 mouse: influence of injection route.
Experimental Autoimmune Encephalomyelitis (EAE) Model of Cynomolgus Macaques Induced by Recombinant Human MOG1-125 (rhMOG1-125) Protein and MOG34-56 Peptide.
Experimental autoimmune encephalomyelitis accelerates remyelination after lysophosphatidylcholine-induced demyelination in the corpus callosum.
Experimental Autoimmune Encephalomyelitis Develops in CC Chemokine Receptor 7-deficient Mice with Altered T-cell Responses.
Experimental autoimmune encephalomyelitis in cynomolgus monkeys.
Experimental autoimmune encephalomyelitis in the Wistar rat: dependence of MBP-specific T cell responsiveness on B7 costimulation.
Experimental autoimmune posterior uveitis accompanied by epitheloid cell accumulations (EAPU). A new type of experimental ocular disease induced by immunization with PEP-65, a pigment epithelial polypeptide preparation.
Experimental autoimmune uveoretinitis (EAU) in rats: abrogation of resistance to the induction and augmentation of the inflammation by pertussis toxin.
Experimental autoimmune uveoretinitis in mice. Induction by a single eliciting event and dependence on quantitative parameters of immunization.
Experimental autoimmune uveoretinitis in the rat and mouse.
Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis.
Experimental melanin-protein induced uveitis (EMIU) is the sole type of uveitis evoked by a diversity of ocular melanin preparations and melanin-derived soluble polypeptides.
Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1? production by myeloid cells.
Experimental researches on the role of phosphoinositide-specific phospholipase C in 4-hydroxynonenal induced exocytosis.
Experimental studies on the mechanism of phospholipase C activation by the lipid peroxidation products 4-hydroxynonenal and 2-nonenal.
Exploring cargo transport mechanics in the type IV secretion systems.
Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5.
Expression and a role of functionally coupled P2Y receptors in human dendritic cells.
Expression and activation of matrix metalloproteinase-9 and NADPH oxidase in tissues and plasma of experimental autoimmune encephalomyelitis in mice.
Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes.
Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils.
Expression and characterization of the bovine histamine H1 receptor in cDNA-transfected C6 astroglioma cells.
Expression and function of adenosine receptors in human dendritic cells.
Expression and function of umami receptors T1R1/T1R3 in gastric smooth muscle.
Expression and functional characterization of a melatonin-sensitive receptor in Xenopus oocytes.
Expression and functional role of formyl peptide receptor in human bone marrow-derived mesenchymal stem cells.
Expression and immunogenicity of pertussis toxin S1 subunit-tetanus toxin fragment C fusions in Salmonella typhi vaccine strain CVD 908.
Expression and immunological properties of the five subunits of pertussis toxin.
Expression and modulation of 5-hydroxytryptamine1A receptors in P11 cells.
Expression and molecular pharmacology of the mouse CRTH2 receptor.
Expression and muscarinic receptor coupling of Lyn kinase in cultured human airway smooth muscle cells.
Expression and mutagenesis of recombinant cholera toxin A subunit.
Expression and pharmacological characterization of a stimulatory subtype of adenosine receptor in fetal chick ventricular myocytes.
Expression and potential functions of G-protein alpha subunits in embryos of Xenopus laevis.
Expression and purification of a trivalent pertussis toxin-diphtheria toxin-tetanus toxin fusion protein in Escherichia coli.
Expression and purification of functional G protein alpha subunits using a baculovirus expression system.
Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.
Expression and secretion of beta-glucuronidase and Pertussis toxin S1 by Streptomyces lividans.
Expression and secretion of pertussis toxin subunit S1 in Bacillus subtilis.
Expression and secretion of the S-1 subunit and C180 peptide of pertussis toxin in Escherichia coli.
Expression and secretion of the S2 subunit of pertussis toxin in Bacillus brevis.
Expression and Signaling of Formyl-Peptide Receptors in the Brain.
Expression and Signaling of G Protein-Coupled Estrogen Receptor (GPER) in Rat Sertoli Cells.
Expression of a C terminally truncated form of pertussis toxin S1 subunit effectively induces protection against pertussis toxin following DNA-based immunization.
Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.
Expression of a functional endothelin (ETA) receptor in human meningiomas.
Expression of a G protein subunit, alpha i-1, in Balb/c 3T3 cells leads to agonist-specific changes in growth regulation.
Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation.
Expression of a pertussis toxin S1 fragment by inducible promoters in oral Streptococcus and the induction of immune responses during oral colonization in mice.
Expression of a synthetic pertussis toxin operon in Escherichia coli.
Expression of adenylyl cyclase isoforms in neutrophils.
Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells.
Expression of alpha 2-receptor-mediated responses by insulin in primary culture of rat hepatocytes.
Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes.
Expression of Astrocytic Type 2 Angiotensin Receptor in Central Nervous System Inflammation Correlates With Blood-Brain Barrier Breakdown.
Expression of bacterial cytotoxin genes in mammalian target cells.
Expression of Bordetella pertussis Antigens Fused to Different Vectors and Their Effectiveness as Vaccines.
Expression of Ca(2+)-mobilizing endothelin(A) receptors and their role in the control of Ca(2+) influx and growth hormone secretion in pituitary somatotrophs.
Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP.
Expression of cytokines by human astrocytomas following stimulation by C3a and C5a anaphylatoxins: specific increase in interleukin-6 mRNA expression.
Expression of DP2 (CRTh2), a prostaglandin D? receptor, in human mast cells.
Expression of functional chemokine receptors by rat cerebellar neurons.
Expression of functional GPR35 in human iNKT cells.
Expression of functional Y1 receptors for neuropeptide Y in human Ewing's sarcoma cell lines.
Expression of GTP-binding proteins and protein kinase C isozymes in platelet-like particles derived from megakaryoblastic leukemia cells (MEG-01).
Expression of Histamine HReceptors in Xenopus Oocytes Injected with Messenger Ribonucleic Acid from Bovine Adrenal Medulla: Pertussis Toxin Insensitive Activation of Membrane Chloride Currents.
Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation.
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines.
Expression of membrane progesterone receptors (mPRs) in rat peripheral glial cell membranes and their potential role in the modulation of cell migration and protein expression.
Expression of muscarinic M2 receptors in cultured human airway smooth muscle cells.
Expression of opioid receptors during heart ontogeny in normotensive and hypertensive rats.
Expression of P2Y receptors in cell lines derived from the human lung.
Expression of pertussis toxin adenosine diphosphate-ribosyltransferase in a T-cell hybridoma reduces metastatic capacity.
Expression of pertussis toxin correlates with pathogenesis in Bordetella species.
Expression of pertussis toxin in Bordetella bronchiseptica and Bordetella parapertussis carrying recombinant plasmids.
Expression of pertussis toxin subunit S4 as an intracytoplasmic protein in Bacillus subtilis.
Expression of protease-activated receptors (PARs) in OLN-93 oligodendroglial cells and mechanism of PAR-1-induced calcium signaling.
Expression of RGS2 alters the coupling of metabotropic glutamate receptor 1a to M-type K+ and N-type Ca2+ channels.
Expression of somatostatin receptor genes and their role in inhibiting Cl- secretion in HT-29cl.19A colonocytes.
Expression of the C-C chemokine receptor CCR3 in human airway epithelial cells.
Expression of the mammalian calcium signaling response to Trypanosoma cruzi in Xenopus laevis oocytes.
Expression of the mu-opioid receptor in CHO cells: ability of mu-opioid ligands to promote alpha-azidoanilido[32P]GTP labeling of multiple G protein alpha subunits.
Expression of the nerve growth factor gene is controlled by the microtubule network.
Expression of the S-1 catalytic subunit of pertussis toxin in Escherichia coli.
Expression of the S1 sub-unit of pertussis toxin using a recombinant baculovirus.
Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R.
Expression of the type-II phospholipase A2 in alveolar macrophages. Down-regulation by an inflammatory signal.
Expression of val-12 mutant ras p21 in an IL-3-dependent murine myeloid cell line is associated with loss of serum-dependence and increases in membrane PIP2-specific phospholipase C activity.
Expression, activity and cytotoxicity of pertussis toxin S1 subunit in transfected mammalian cells.
Extensive swelling after booster doses of acellular pertussis-tetanus-diphtheria vaccines.
External quality assessment of pertussis serology in Germany.
External support modulates G protein expression and receptor coupling in experimental vein grafts.
Extra Virgin Olive Oil Phenols Vasodilate Rat MesentericResistance Artery via Phospholipase C (PLC)-CalciumMicrodomains-Potassium Channels (BKCa) Signals.
Extracellular ATP activates different signalling pathways in rat Sertoli cells.
Extracellular ATP and ADP stimulate proliferation of porcine aortic smooth muscle cells.
Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells.
Extracellular ATP augments mesangial cell growth induced by multiple growth factors.
Extracellular ATP elevates cytoplasmatic free Ca2+ in HeLa cells by the interaction with a 5'-nucleotide receptor.
Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes.
Extracellular ATP increases [CA(2+)](i) in distal tubule cells. I. Evidence for a P2Y2 purinoceptor.
Extracellular ATP itself elicits superoxide generation in guinea pig peritoneal macrophages.
Extracellular ATP mediates Ca2+ signaling in cultured myenteric neurons via a PLC-dependent mechanism.
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors.
Extracellular ATP stimulates increases in Na+/K+ pump activity, intracellular pH and uridine uptake in cultures of mammalian cells.
Extracellular ATP stimulates polyphosphoinositide hydrolysis and prostaglandin synthesis in rat renal mesangial cells. Involvement of a pertussis toxin-sensitive guanine nucleotide binding protein and feedback inhibition by protein kinase C.
Extracellular ATP-mediated phospholipase A(2) activation in rat thyroid FRTL-5 cells: regulation by a G(i)/G(o) protein, Ca(2+), and mitogen-activated protein kinase.
Extracellular calcium and platelet-derived growth factor promote receptor-mediated chemotaxis in osteoblasts through different signaling pathways.
Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis.
Extracellular lipid-mediated signaling in tumor-cell activation and pseudopod protrusion.
Extracellular matrix proteins are potent agonists of human smooth muscle cell migration.
Extracellular mRNA induces dendritic cell activation by stimulating tumor necrosis factor-alpha secretion and signaling through a nucleotide receptor.
Extracellular nucleotide-induced [Ca2+]i elevation in rat basilar smooth muscle cells.
Extracellular nucleotides act through P2U purinoceptors to elevate [Ca2+]i and enhance basic fibroblast growth factor-induced proliferation in sheep chondrocytes.
Extracellular signal-regulated kinase 1/2 activation by myometrial oxytocin receptor involves Galpha(q)Gbetagamma and epidermal growth factor receptor tyrosine kinase activation.
Extracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle.
Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells.
Extracellular signal-regulated kinase-1 and -2 respond differently to mitogenic and differentiative signaling pathways in myoblasts.
Extracellular signal-regulated kinases and g protein-coupled receptors in megakaryocytic human erythroleukemia cells: selective activation, differential regulation, and dissociation from mitogenesis.
F11 neuroblastoma x DRG neuron hybrid cells express inhibitory mu- and delta-opioid receptors which increase voltage-dependent K+ currents upon activation.
Facilitation and inhibition of G-protein regulated protein secretion by melatonin.
Facilitation of T-type calcium current in bullfrog atrial cells: voltage-dependent relief of a G protein inhibitory tone.
Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y(1) receptors.
Facilitative actions of the protein kinase-C effector system on hormonally stimulated adenosine 3',5'-monophosphate production by swine luteal cells.
Facilitative interactions between vasoactive intestinal polypeptide and receptor type-selective opioids: implications for sensory afferent regulation of spinal opioid action.
Facilitatory coupling between a glutamate metabotropic receptor and dihydropyridine-sensitive calcium channels in cultured cerebellar granule cells.
Facilitatory effects of diltiazem on dopamine release in the central nervous system. Focus on interactions with D2 autoreceptors and guanosine triphosphate binding proteins.
Factors affecting prostacyclin receptor agonist efficacy in different cell types.
Factors determining specificity of signal transduction by G-protein-coupled receptors. Regulation of signal transfer from receptor to G-protein.
Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. I. Coupling of alpha 2-adrenergic receptor subtypes to distinct G-proteins.
Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. III. Coupling of alpha 2-adrenergic receptor subtypes in a cell type-specific manner.
Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. Integration of stimulatory and inhibitory input to the effector adenylyl cyclase.
Failure of pertussis toxin to inhibit activation of guanylate cyclase by the heat-stable enterotoxin of Escherichia coli (STa) in the T84 cell line.
Failure of [32P]ADP-ribosylation by pertussis toxin to determine Gi alpha content in membranes from various human tissues. Improved radioimmunological quantification using the 125I-labelled C-terminal decapeptide of retinal transducin.
Fast, antigen-saving multiplex immunoassay to determine levels and avidity of mouse serum antibodies to pertussis, diphtheria, and tetanus antigens.
Fast, local signal transduction between the mu opioid receptor and Ca2+ channels.
Fat cell adenylate cyclase system. Enhanced inhibition by adenosine and GTP in the hypothyroid rat.
Fatal pertussis in the neonatal mouse model is associated with pertussis toxin-mediated pathology beyond the airways.
Fc gamma receptor activation of neutrophils in cryoglobulin-induced leukocytoclastic vasculitis.
Fc gamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy. A1 receptors are stimulatory and A2 receptors are inhibitory.
FcepsilonRI-mediated mast cell migration: signaling pathways and dependence on cytosolic free Ca2+ concentration.
Fear-potentiated startle: a neural and pharmacological analysis.
Feasibility study of a combined diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine, and comparison of clinical reactions and immune responses with diphtheria-tetanus-acellular pertussis (DTPa) and hepatitis B vaccines applied as mixed or injected into separate limbs.
Feasible improvements in vaccines in the Expanded Programme on Immunization.
Features of the translocation of protein kinase C in neutrophils stimulated with the chemotactic peptide f-Met-Leu-Phe.
Fed-batch cultivation of Bordetella pertussis: metabolism and Pertussis Toxin production.
Fertilization promoting peptide and adenosine, acting as first messengers, regulate cAMP production and consequent protein tyrosine phosphorylation in a capacitation-dependent manner.
FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells.
Fibroblast growth factor potentiates receptor- and nonreceptor-mediated stimulation of adenylate cyclase in hamster fibroblasts.
Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism.
Fibronectin increases RhoA activity through inhibition of PKA in the human gastric cancer cell line SGC-7901.
Fibronectin promotes calcium signaling by interferon-gamma in human neutrophils via G-protein and sphingosine kinase-dependent mechanisms.
Fibronectin upregulates gelatinase B (MMP-9) and induces coordinated expression of gelatinase A (MMP-2) and its activator MT1-MMP (MMP-14) by human T lymphocyte cell lines. A process repressed through RAS/MAP kinase signaling pathways.
Filamentous hemagglutinin and pertussis toxin from Bordetella pertussis modulate immune responses to unrelated antigens.
Filamentous hemagglutinin and pertussis toxin promote adherence of Bordetella pertussis to cilia.
Filamentous hemagglutinin has a major role in mediating adherence of Bordetella pertussis to human WiDr cells.
Filamentous hemagglutinin of Bordetella bronchiseptica is required for efficient establishment of tracheal colonization.
Fimbrial phase variation in Bordetella pertussis: a novel mechanism for transcriptional regulation.
Fingolimod inhibits glutamate release through activation of S1P1 receptors and the G protein ?? subunit-dependent pathway in rat cerebrocortical nerve terminals.
Fingolimod protects cultured cortical neurons against excitotoxic death.
First report and detailed characterization of B. pertussis isolates not expressing Pertussis Toxin or Pertactin.
Fish somatostatin sst3 receptor: comparison of radioligand and GTPgammaS binding, adenylate cyclase and phospholipase C activities reveals different agonist-dependent pharmacological signatures.
Fixation traps formyl peptide receptors in high and low affinity forms that can be regulated by GTP[S] in the absence of ligand.
FK506 and pertussis toxin distinguish growth-induced locomotor activation from attractant-stimulated locomotion in human blood lymphocytes.
Flow-induced prostacyclin production is mediated by a pertussis toxin-sensitive G protein.
Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1.
Fluorescence correlation spectroscopy detects galanin receptor diversity on insulinoma cells.
Fluorescence spectroscopy studies of HEK293 cells expressing DOR-G(i)1? fusion protein; the effect of cholesterol depletion.
Fluorescent labeling of signal-transducing G-proteins. Pertussis toxin-catalyzed etheno-ADP ribosylation of transducin.
Fluoride activation of neutrophils: similarities to formylmethionyl-leucyl-phenylalanine.
Fluoride can activate the respiratory burst independently of Ca2+, stimulation of phosphoinositide turnover and protein kinase C translocation in primed human neutrophils.
Fluoride mobilizes intracellular calcium and promotes Ca2+ influx in rat proximal tubules.
Fluoride produces endothelium-dependent relaxation and endothelium-independent contraction in coronary artery.
Fluoride-mediated activation of guinea pig neutrophils.
Fluoride-mediated activation of the respiratory burst in electropermeabilized neutrophils.
Fluoroaluminate induces pertussis toxin-sensitive protein phosphorylation: differences in MC3T3-E1 osteoblastic and NIH3T3 fibroblastic cells.
Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells.
Fluoroaluminates mimic muscarinic- and oxytocin-receptor-mediated generation of inositol phosphates and contraction in the intact guinea-pig myometrium. Role for a pertussis/cholera-toxin-insensitive G protein.
Fluprostenol activates phospholipase C and Ca2+ mobilization in human myometrial cells.
FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase.
FMLP- and TNF-stimulated monoclonal Lym-1 antibody-dependent lysis of B lymphoblastoid tumour targets by neutrophils.
fMLP-induced in vitro nitric oxide production and its regulation in murine peritoneal macrophages.
FMRFamide modulation of secretory machinery underlying presynaptic inhibition of synaptic transmission requires a pertussis toxin-sensitive G-protein.
FMS*Calciumfluor increases alkaline phosphatase expression during osteogenesis in vitro of tibia-derived rat osteoblasts by activation of G alpha 0/G alpha i proteins.
FMS*Calciumfluor specifically increases mRNA levels and induces signaling via MAPK 42,44 and not FAK in differentiating rat osteoblasts.
Foetal-calf serum stimulates a pertussis-toxin-sensitive high-affinity GTPase activity in rat glioma C6 BU1 cells.
Follicle-stimulating hormone evokes an increase in intracellular free calcium ion concentrations in single ovarian (granulosa) cells.
Follicle-stimulating hormone receptor-mediated uptake of 45Ca2+ by cultured rat Sertoli cells does not require activation of cholera toxin- or pertussis toxin-sensitive guanine nucleotide binding proteins or adenylate cyclase.
Follicular Fluid High-Density Lipoprotein (FF-HDL)-Associated Sphingosine 1-Phosphate (S1P) Promotes Human Granulosa Lutein Cell Migration via S1P Receptor Type 3 (S1PR3) and Small G Protein RAC1.
Food allergens are protected from degradation during CD23-mediated transepithelial transport.
Formation and function of eicosanoids in the central nervous system.
Formation of inositol (1,4,5) trisphosphate and increase of cytosolic Ca2+ mediated by Fc receptors in human neutrophils.
Formyl peptide receptor expression in birds.
Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase.
Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-kappaB kinase in human U87 astrocytoma cells.
Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production.
Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils.
Forskolin-induced homologous desensitization via an adenosine 3',5'-monophosphate-dependent mechanism(s) in human osteoblast-like SaOS-2 cells.
Forskolin-resistant Y1 mutants harbor defects associated with the guanyl nucleotide-binding regulatory protein, Gs.
Four single-basepair mutations in the ptx promoter of Bordetella bronchiseptica are sufficient to activate the expression of pertussis toxin.
FPRL1-mediated induction of superoxide in LL-37-stimulated IMR90 human fibroblast.
Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway.
Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow.
Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation.
Fractalkine stimulates angiogenesis by activating the Raf-1/MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways.
Fractalkine-mediated endothelial cell injury by NK cells.
Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon.
Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice.
Frequency of pertussis in children with prolongued cough.
Frequency of serological evidence of Bordetella infections and mixed infections with other respiratory pathogens in university students with cough illnesses.
FSH directly regulates chondrocyte dedifferentiation and cartilage development.
FSH mediated cAMP signalling upregulates the expression of G? subunits in pubertal rat Sertoli cells.
Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms.
Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2.
Functional activation of human neutrophils by recombinant monocyte-derived neutrophil chemotactic factor/IL-8.
Functional alpha 2-adrenergic receptor-Gs coupling undergoes agonist-promoted desensitization in a subtype-selective manner.
Functional alpha 2-adrenoceptors in rat adipocytes: inhibition of cyclic AMP accumulation.
Functional alpha2C-adrenoceptors in human neuroblastoma SH-SY5Y cells.
Functional analysis of a dominant negative mutant of G alpha i2.
Functional analysis of a human A(1) adenosine receptor/green fluorescent protein/G(i1)alpha fusion protein following stable expression in CHO cells.
Functional analysis of guinea pig ?1-adrenoceptor.
Functional analysis of the D2L dopamine receptor expressed in a cAMP-responsive luciferase reporter cell line.
Functional analysis of the pertussis toxin promoter.
Functional and molecular characterization of CCK receptors in the rat pancreatic acinar cell line AR 4-2J.
Functional and molecular characterization of VIP receptor--effector system in rat developing immunocompetent cells: G protein involvement.
Functional and molecular evidence for P2X receptors in LLC-PK1 cells.
Functional and molecular properties of the human recombinant Y4 receptor: resistance to agonist-promoted desensitization.
Functional and structural consequences of chemokine (C-X-C motif) receptor 4 activation with cognate and non-cognate agonists.
Functional annotation of the putative orphan Caenorhabditis elegans G-protein-coupled receptor C10C6.2 as a FLP15 peptide receptor.
Functional assessment of recombinant human alpha(2)-adrenoceptor subtypes with cytosensor microphysiometry.
Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes.
Functional characterization and mRNA expression of pituitary adenylate cyclase activating polypeptide (PACAP) type I receptors in rat peritoneal macrophages.
Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay.
Functional characterization of a human receptor for neuropeptide FF and related peptides.
Functional characterization of a rat dopamine D-2 receptor cDNA expressed in a mammalian cell line.
Functional characterization of alpha1-adrenergic receptors in experimental vein grafts.
Functional characterization of an endogenous Xenopus oocyte adenosine receptor.
Functional characterization of P2Y and P2X receptors in human eosinophils.
Functional characterization of the Na(+)-H+ exchanger in rat mast cells: crosstalks between different kinase pathways.
Functional characterization of three mutations of the endothelin B receptor gene in patients with Hirschsprung's disease: evidence for selective loss of Gi coupling.
Functional compartmentalization of ATP is involved in angiotensin II-mediated closure of cardiac ATP-sensitive K+ channels.
Functional compartments in rat mast cells for cAMP and calcium on histamine release.
Functional coupling between endothelin receptors and multiple G-proteins in rat heart myocytes.
Functional coupling between heterologously expressed dopamine D(2) receptors and KCNQ channels.
Functional coupling between human E-type Ca2+ channels and mu opioid receptors expressed in Xenopus oocytes.
Functional coupling of cerebral ?-aminobutyric acid (GABA)(B) receptor with adenylate cyclase system: effect of phaclofen.
Functional coupling of human L-type Ca2+ channels and angiotensin AT1A receptors coexpressed in xenopus laevis oocytes: involvement of the carboxyl-terminal Ca2+ sensors.
Functional coupling of human metabotropic glutamate receptor hmGlu1d: comparison to splice variants hmGlu1a and -1b.
Functional coupling of mu-receptor-Galphai-tethered proteins in AtT20 cells.
Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade.
Functional coupling of the alpha 2-adrenergic receptor-adenylate cyclase complex in the pregnant human myometrium.
Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes.
Functional coupling of the delta-, mu-, and kappa-opioid receptors to mitogen-activated protein kinase and arachidonate release in Chinese hamster ovary cells.
Functional coupling of the human dopamine D3 receptor in a transfected NG 108-15 neuroblastoma-glioma hybrid cell line.
Functional coupling of the NK1 tachykinin receptor to phospholipase D in chinese hamster ovary cells and astrocytoma cells.
Functional coupling of the nociceptin/orphanin FQ receptor in dog brain membranes.
Functional cross-talk between endothelial muscarinic and alpha2-adrenergic receptors in rabbit cerebral arteries.
Functional differences and interactions between phenotypic subpopulations of olfactory ensheathing cells in promoting CNS axonal regeneration.
Functional differences between monocyte chemotactic protein-1 receptor A and monocyte chemotactic protein-1 receptor B expressed in a Jurkat T cell.
Functional domains of delta- and mu-opioid receptors responsible for adenylyl cyclase inhibition.
Functional domains of the mouse beta3-adrenoceptor associated with differential G protein coupling.
Functional evidence for biased inhibition of G protein signaling by YM-254890 in human coronary artery endothelial cells.
Functional expression and characterization of human D2 and D3 dopamine receptors.
Functional expression and FRET analysis of green fluorescent proteins fused to G-protein subunits in rat sympathetic neurons.
Functional expression of a novel ginsenoside Rf binding protein from rat brain mRNA in Xenopus laevis oocytes.
Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.
Functional expression of formyl peptide receptor family in human NK cells.
Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells.
Functional expression of human D3 dopamine receptors in differentiated neuroblastoma x glioma NG108-15 cells.
Functional expression of metabotropic GABA(B) receptors in primary cultures of astrocytes from rat cerebral cortex.
Functional expression of N-formyl peptide receptors in human bone marrow-derived mesenchymal stem cells.
Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes.
Functional expression of the GABAB receptor in human airway smooth muscle.
Functional expression of the human receptor for colony-stimulating factor 1 (CSF-1) in hamster fibroblasts: CSF-1 stimulates Na+/H+ exchange and DNA-synthesis in the absence of phosphoinositide breakdown.
Functional expression of the macrophage colony-stimulating factor receptor in human THP-1 monocytic leukemia cells.
Functional expression of the murine D2, D3, and D4 dopamine receptors in Xenopus laevis oocytes.
Functional expression of the P2Y14 receptor in human neutrophils.
Functional expression of the P2Y14 receptor in murine T-lymphocytes.
Functional expression, activation and desensitization of opioid receptor-like receptor ORL1 in neuroblastoma x glioma NG108-15 hybrid cells.
Functional high efficiency expression of cloned leukocyte chemoattractant receptor cDNAs.
Functional interaction of melatonin receptors and D1 dopamine receptors in cultured chick retinal neurons.
Functional interaction of prostaglandin E receptor EP3 subtype with guanine nucleotide-binding proteins, showing low-affinity ligand binding.
Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
Functional interactions between colony-stimulating factors and the insulin family hormones for human myeloid leukemic cells.
Functional maturation of human T lymphocytes is accompanied by changes in the G-protein pattern.
Functional maturation of somatostatin neurons and somatostatin receptors during development of mouse hypothalamus in vivo and in vitro.
Functional modification by cholera-toxin-catalyzed ADP-ribosylation of a guanine-nucleotide-binding regulatory protein serving as the substrate of pertussis toxin.
Functional platelet-activating factor receptors linked to inositol lipid hydrolysis, calcium mobilization and tyrosine kinase activity in the human endometrial HEC-1B cell line.
Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors.
Functional reconstitution of detergent-solubilized bovine calf testis luteinizing hormone/chorionic gonadotropin receptor into phospholipid vesicles.
Functional reconstitution of prostaglandin E receptor from bovine adrenal medulla with guanine nucleotide binding proteins.
Functional regulation of GTP-binding protein coupled to insulin-like growth factor-I receptor by lithium during G1 phase of the rat thyroid cell cycle.
Functional remodeling in post-myocardial infarcted rats: focus on beta-adrenoceptor subtypes.
Functional responses of cloned muscarinic receptors expressed in CHO-K1 cells.
Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp.
Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling.
Functional role of M2 muscarinic receptors in the guinea pig ileum.
Functional SDF1 alpha/CXCR4 signaling in the developing spinal cord.
Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.
Functional somatostatin receptors on a rat pancreatic acinar cell line.
Functional specialization of fibronectin-binding beta 1-integrins in T lymphocyte migration.
Functional studies in the human submandibular duct cell line, HSG-PA, suggest a second salivary gland receptor subtype for nucleotides.
Functional trans-inactivation of insulin receptor kinase by growth-inhibitory angiotensin II AT2 receptor.
Functional uncoupling between the receptor and G-protein as the result of PKC activation, observed in Aplysia neurons.
Functional uncoupling of muscarinic receptors from adenylate cyclase in rat cardiac membranes by the active component of islet-activating protein, pertussis toxin.
Functional uncoupling of the inhibitory alpha 1-adrenergic response from a G-protein in innervated cultured cardiac cells by K+ depolarization.
Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell.
Functionally distinct muscarinic receptors on gastric somatostatin cells.
Functionally Selective Inhibition of the Oxytocin Receptor by Retosiban in Human Myometrial Smooth Muscle.
Further analyses of mechanisms underlying the antinociceptive effect of the triterpene 3?, 6?, 16?-trihydroxylup-20(29)-ene in mice.
Further analysis of ATP-mediated activation of K+ channels in renal epithelioid Madin Darby canine kidney (MDCK) cells.
Further analysis of the sequence of the S1 subunit of pertussis toxin.
Further characterization of 5-HT- and 5-HT3 receptor agonists'-stimulated phosphoinositol phosphates accumulation.
Further characterization of alpha N-acetyl beta-endorphin-(1-31) regulatory activity, I: Effect on opioid- and alpha 2-mediated supraspinal antinociception in mice.
Further characterization of Japanese acellular pertussis vaccine prepared in 1988 by 6 Japanese manufacturers.
Further characterization of the D2 dopamine receptor expressed in MMQ cells.
Further contributions to an improved pertussis vaccine: I. Molecular mechanisms of pertussis toxin.
Further Elucidation of a Pertussis Toxin-Sensitive Transmembrane Signaling Mechanism Involved in Central alpha(2)-Adrenoceptor Activation in the Rat.
Further evaluation of the pertussis component vaccine produced by apoceruloplasmin affinity chromatography.
Further evidence for a phospholipase C-coupled G protein in hamster fibroblasts. Induction of inositol phosphate formation by fluoroaluminate and vanadate and inhibition by pertussis toxin.
Further evidence for the involvement of a phosphoprotein in the respiratory burst oxidase of human neutrophils.
Further evidence that the CCK2 receptor is coupled to two transduction pathways using site-directed mutagenesis.
Fusion expression and immunogenicity of Bordetella pertussis PTS1-FHA protein: implications for the vaccine development.
Future vaccine development at NICHD.
Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells.
G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits.
G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells.
G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions.
G alpha q/11 mediates neurotensin excitation of substantia nigra dopaminergic neurons.
G alpha(i-2) mediates renal LLC-PK1 growth by a Raf-independent activation of p42/p44 MAP kinase.
G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor.
G protein activation and cyclic AMP modulation by naloxone benzoylhydrazone in distinct layers of rat olfactory bulb.
G protein activation by human dopamine D3 receptors in high-expressing Chinese hamster ovary cells: A guanosine-5'-O-(3-[35S]thio)- triphosphate binding and antibody study.
G protein activation inhibits amiloride-blockable highly selective sodium channels in A6 cells.
G Protein Activation Stimulates Phospholipase D Signaling in Plants.
G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides.
G protein beta 5 subunit interactions with alpha subunits and effectors.
G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha.
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
G protein beta2 subunit interacts directly with neuropathy target esterase and regulates its activity.
G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation.
G protein betagamma11 complex translocation is induced by Gi, Gq and Gs coupling receptors and is regulated by the alpha subunit type.
G protein control of inositol lipids in intact vascular smooth muscle.
G protein control of potassium channel activity in a mast cell line.
G protein coupled receptor signaled apoptosis is associated with activation of a cation insensitive acidic endonuclease and intracellular acidification.
G protein coupling of antigen receptor-stimulated polyphosphoinositide hydrolysis in B cells.
G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A2A receptors.
G protein coupling of the rat A1-adenosine receptor--partial purification of a protein which stabilizes the receptor-G protein association.
G protein coupling profile of mGluR6 and expression of G alpha proteins in retinal ON bipolar cells.
G protein coupling to M1 and M3 muscarinic receptors in sublingual glands.
G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.
G protein expression and adenylate cyclase regulation in ventricular cardiomyocytes from STZ-diabetic rats.
G protein expression and second messenger formation in human granulosa cells.
G protein function in the ischaemic myocardium.
G protein G alpha i-2 inhibits outwardly rectifying chloride channels in human airway epithelial cells.
G protein G alpha q/11 and G alpha i1,2 are activated by pancreastatin receptors in rat liver: studies with GTP-gamma 35S and azido-GTP-alpha-32P.
G protein in stimulation of PI hydrolysis by CCK in isolated rat pancreatic acinar cells.
G Protein independent phosphorylation and internalization of the delta-opioid receptor.
G protein is coupled to presynaptic glutamate and GABA receptors in lobster neuromuscular synapse.
G protein modulates thyroid hormone-induced Na(+) channel activation in ventricular myocytes.
G protein modulation of omega-conotoxin binding sites in neuroblastoma x glioma NG 108-15 hybrid cells.
G protein preferences for dopamine D2 inhibition of prolactin secretion and DNA synthesis in GH4 pituitary cells.
G protein specificity of the muscarine-induced increase in an inward rectifier potassium current in AtT-20 cells.
G protein specificity: traffic direction required.
G protein subunit, alpha i-3, activates a pertussis toxin-sensitive Na+ channel from the epithelial cell line, A6.
G protein subunits and the stimulation of phospholipase C by Gs-and Gi-coupled receptors: Lack of receptor selectivity of Galpha(16) and evidence for a synergic interaction between Gbeta gamma and the alpha subunit of a receptor activated G protein.
G protein threshold behavior in the human neutrophil oxidant response: measurement of G proteins available for signaling in responding and nonresponding subpopulations.
G protein {beta}{gamma} subunits mediate presynaptic inhibition of transmitter release from rat superior cervical ganglion neurones in culture.
G protein-activated K+ channels: a reporter for rapid activation of G proteins by lysophosphatidic acid in Xenopus oocytes.
G protein-adrenergic interactions in the heart.
G protein-associated, specific membrane binding sites mediate the neuroprotective effect of dehydroepiandrosterone.
G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility.
G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current.
G protein-coupled estrogen receptor 1 (GPER1)/GPR30 increases ERK1/2 activity through PDZ motif-dependent and -independent mechanisms.
G protein-coupled inward rectifier modulated by dopamine agonists in cultured substantia nigra neurons.
G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells.
G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning.
G protein-coupled receptor-induced sensitization of phospholipase C stimulation by receptor tyrosine kinases.
G protein-coupled receptors mediate a fast excitatory postsynaptic current in CA3 pyramidal neurons in hippocampal slices.
G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases.
G protein-dependent activation of smooth muscle eNOS via natriuretic peptide clearance receptor.
G protein-independent activation of an inward Na(+) current by muscarinic receptors in mouse pancreatic beta-cells.
G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation.
G protein-mediated activation of a nonspecific cation current in cultured rat retinal pigment epithelial cells.
G protein-mediated FMRFamidergic modulation of calcium influx in dissociated heart muscle cells from squid, Loligo forbesii.
G protein-mediated inhibition of inwardly rectifying K+ channels in guinea pig chromaffin cells.
G protein-mediated inhibition of phospholipase C activity in a solubilized membrane preparation.
G protein-mediated inhibitory effect of a nitric oxide donor on the L-type Ca2+ current in rat ventricular myocytes.
G protein-mediated mitogen-activated protein kinase activation by two dopamine D2 receptors.
G protein-mediated suppression of L-type Ca2+ current by interleukin-1 beta in cultured rat ventricular myocytes.
G proteins and endothelium-dependent relaxations.
G proteins and phospholipase C mediate thrombin-induced generation of plasminogen activator inhibitor-1 from vascular smooth muscle cells.
G proteins and regulation of pyruvate dehydrogenase activity by insulin in human circulating lymphocytes.
G proteins couple alpha-adrenergic and GABAb receptors to inhibition of peptide secretion from peripheral sensory neurons.
G proteins G?i1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization.
G proteins in adipocytes and preadipocytes: characterization, subcellular distribution, and potential roles for Gi2 and/or Gi3 in the control of cell proliferation.
G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide.
G proteins in Aplysia: biochemical characterization and regional and subcellular distribution.
G proteins in carotid body chemoreception.
G proteins mediate suppression of Ca2+-activated K current by acetylcholine in smooth muscle cells.
G proteins of the Gq family couple the H2 histamine receptor to phospholipase C.
G proteins regulate calcium channels in the luminal membranes of the rabbit nephron.
G proteins subserve relaxations mediated by adenosine receptors in human coronary artery.
G regulatory proteins and muscarinic receptor signal transduction in mucous acini of rat submandibular gland.
G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling.
G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies.
G(i)-dependent suppression of beta(1)-adrenoceptor effects in ventricular myocytes from NE-treated guinea pigs.
G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways.
G(i-1)/G(i-2)-dependent signaling by single-transmembrane natriuretic peptide clearance receptor.
G(i/o) Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX).
G(o) activation is required for both appetitive and aversive memory acquisition in Drosophila.
G(o) protein does not regulate ATP-stimulated [Ca2+]i elevation or noradrenaline release in PC12 cells.
G(o) signaling is required for Drosophila associative learning.
G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.
G(o)2 and Gi3 proteins mediate the action of somatostatin on membrane Ca2+ and K+ currents in ovine pituitary somatotrophs.
G(s) protein dysfunction in allergen-challenged human isolated passively sensitized bronchi.
G(z alpha) deficient mice: enzyme levels in the autonomic nervous system, neuronal survival and effect of genetic background.
G(z) can mediate the acute actions of mu- and kappa-opioids but is not involved in opioid-induced adenylyl cyclase supersensitization.
G(z) signaling: emerging divergence from G(i) signaling.
G-protein activation by putative antagonists at mutant Thr373Lys alpha2A adrenergic receptors.
G-protein activation decreases isoflurane inhibition of N-type Ba2+ currents.
G-protein activation mediates prepulse facilitation of Ca2+ channel currents in bovine chromaffin cells.
G-protein activators induce a potassium conductance in murine macrophages.
G-protein activity requirement for polymethylmethacrylate and titanium particle-induced fibroblast interleukin-6 and monocyte chemoattractant protein-1 release in vitro.
G-protein alpha subunit Gi(alpha)2 mediates erythropoietin signal transduction in human erythroid precursors.
G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils.
G-protein beta gamma subunits mediate specific phosphorylation of the protein-tyrosine phosphatase SH-PTP1 induced by lysophosphatidic acid.
G-protein control of cardiac potassium channels.
G-protein coupled activation of potassium channels by endogenous neuropeptides in snail neurons.
G-protein coupled progesterone receptors in the plasma membrane of fungus Rhizopus nigricans.
G-Protein coupled progesterone receptors in the plasma membrane of fungus Rhizopus nigricans.
G-protein coupling and signalling of Y1-like neuropeptide Y receptors in SK-N-MC cells.
G-protein dependent potentiation of calcium release from sarcoplasmic reticulum of skeletal muscle.
G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe.
G-protein distribution in canine cardiac sarcoplasmic reticulum and sarcolemma: comparison to rabbit skeletal muscle membranes and to brain and erythrocyte G-proteins.
G-protein expression and intimal hyperplasia after arterial injury: a role for Galpha(i) proteins.
G-protein from Medicago sativa: functional association to photoreceptors.
G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones.
G-protein involvement in muscarinic receptor-stimulation of inositol phosphates in longitudinal smooth muscle from the small intestine of the guinea-pig.
G-protein level quantification in platelets and leukocytes from patients with panic disorder.
G-protein mediated responses to localized serotonin application in an invertebrate photoreceptor.
G-protein mediates voltage regulation of agonist binding to muscarinic receptors: effects on receptor-Na+ channel interaction.
G-protein mediation of cannabinoid-induced phospholipase activation.
G-protein modulation of alpha 1A (P/Q) type calcium channel expressed in GH3 cells.
G-protein modulation of neuronal class E (alpha 1E) calcium channel expressed in GH3 cells.
G-protein modulators alter the swimming behavior and calcium influx of Paramecium tetraurelia.
G-protein mRNA levels during adipocyte differentiation.
G-protein regulation of an L-type calcium channel current in canine jejunal circular smooth muscle.
G-protein regulation of outwardly rectified epithelial chloride channels incorporated into planar bilayer membranes.
G-protein regulation of the solubilized human zona pellucida-mediated acrosome reaction and zona pellucida binding.
G-Protein types involved in calcium channel inhibition at a presynaptic nerve terminal.
G-protein-coupled glucocorticoid receptors on the pituitary cell membrane.
G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate.
G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9.
G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway.
G-Protein-coupled receptors and Fcgamma-receptors mediate activation of Akt/protein kinase B in human phagocytes.
G-protein-coupled receptors in HL-60 human leukemia cells.
G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells.
G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes.
G-protein-mediated epidermal growth factor signal transduction in a human breast cancer cell line. Evidence for two intracellular pathways distinguishable by pertussis toxin.
G-protein-mediated regulation of the insulin-responsive glucose transporter in isolated cardiac myocytes.
G-protein-mediated signal transduction for meiosis reinitiation in starfish oocyte.
G-protein-mediated signaling in cholesterol-enriched arterial smooth muscle cells. 2. Role of protein kinase C-delta in the regulation of eicosanoid production.
G-protein-sensitive guanylyl cyclase activity associated with plasma membranes.
G-proteins and adenylyl cyclase in ovarian granulosa cells of amago salmon (Oncorhynchus rhodurus).
G-proteins and egg activation.
G-proteins and endothelial responses.
G-proteins and phospholipase activation in endothelial cells.
G-proteins are involved in 5-HT receptor-mediated modulation of N- and P/Q- but not T-type Ca2+ channels.
G-proteins are involved in contractile responses of isolated mesenteric resistance arteries to agonists.
G-proteins are involved in riluzole inhibition of high voltage-activated calcium channels in rat dorsal root ganglion neurons.
G-proteins as targets for non-immunological histamine releasers.
G-proteins coupled to phosphoinositide hydrolysis in the cochlear and vestibular sensory epithelia of the rat are insensitive to cholera and pertussis toxins.
G-proteins in alpha 1-adrenoceptor mediated prostatic smooth muscle contraction.
G-proteins in guinea pig airway smooth muscle: identification and functional involvement.
G-proteins in rat blood vessels--I. Identification.
G-proteins in rat blood vessels--II. Assessment of functional involvement.
G-proteins in skeletal muscle. Evidence for a 40 kDa pertussis-toxin substrate in purified transverse tubules.
G-proteins in Torpedo marmorata electric organ. Differential distribution in pre- and post-synaptic membranes and synaptic vesicles.
G-proteins mediate inhibition and activation of Ca(2+)-induced exocytosis from SLO-permeabilized peptidergic nerve endings.
G-proteins modulate amiloride-sensitive sodium channels.
G-proteins modulate prolactin- and interleukin-2-stimulated mitogenesis in rat Nb2 lymphoma cells.
G-proteins of fat-cells. Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate.
G-proteins, the inositol lipid signalling pathway, and secretion.
G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.
G?(i2) signaling: friend or foe in cardiac injury and heart failure?
G?14 subunit-mediated inhibition of voltage-gated Ca2+ and K+ channels via neurokinin-1 receptors in rat celiac-superior mesenteric ganglion neurons.
G?i)- and G?i3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes.
G?i-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats.
G?o represses insulin secretion by reducing vesicular docking in pancreatic beta-cells.
G?s proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-?v?3 and CD44-CD44 interactions.
G?s signalling of the CB1 receptor and the influence of receptor number.
GABA and Gi/o differentially control circadian rhythms and synchrony in clock neurons.
GABA is toxic for mouse striatal neurones through a transporter-mediated process.
GABA mediates autoreceptor feedback inhibition in the rat carotid body via presynaptic GABAB receptors and TASK-1.
GABA mediation of the dual effects of somatostatin on guinea pig ileal myenteric cholinergic transmission.
GABA(B) heterodimeric receptors promote Ca(2+) influx via store-operated channels in rat cortical neurons and transfected chinese hamster ovary cells.
GABA(B) presynaptically modulates suprachiasmatic input to hypothalamic paraventricular magnocellular neurons.
GABA(B) receptor activation inhibits N- and P/Q-type calcium channels in cultured lamprey sensory neurons.
GABA(B) receptor activation protects GABA(A) receptor from cyclic AMP-dependent down-regulation in rat cerebellar granule cells.
GABA(B) receptor-mediated stimulation of adenylyl cyclase activity in membranes of rat olfactory bulb.
GABA(B) receptors in anterior pituitary cells. Mechanism of action coupled to endocrine effects.
GABA-induced motility of spinal neuroblasts develops along a ventrodorsal gradient and can be mimicked by agonists of GABAA and GABAB receptors.
GABA-induced potassium channels in cultured neurons.
GABAB receptor activation inhibits Ca2(+)-activated 86Rb-efflux in cultured spinal cord neurons via G-protein mechanism.
GABAB receptor activation inhibits Ca2+-activated potassium channels in synaptosomes: involvement of G-proteins.
GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin.
GABAB receptor-mediated inhibition of Ca2+ currents and synaptic transmission in cultured rat hippocampal neurones.
GABAB receptor-mediated inhibition of spontaneous inhibitory synaptic currents in rat midbrain culture.
GABAB receptor-mediated presynaptic potentiation of ATP ionotropic receptors in rat midbrain synaptosomes.
GABAB receptor-mediated regulation of glutamate-activated calcium transients in hypothalamic and cortical neuron development.
GABAB receptors are expressed in human aortic smooth muscle cells and regulate the intracellular Ca(2+) concentration.
GABAB receptors expressed in Xenopus oocytes by guinea pig cerebral mRNA are functionally coupled with Ca2(+)-dependent Cl- channels and with K+ channels, through GTP-binding proteins.
GABAB receptors inhibit low-voltage activated and high-voltage activated Ca(2+) channels in sensory neurons via distinct mechanisms.
GABAB receptors modulate catecholamine secretion in chromaffin cells by a mechanism involving cyclic AMP formation.
GABAB receptors-associated proteins: potential drug targets in neurological disorders?
GABAB-mediated upregulation of the high-voltage-activated Ca2+ channels in rat dorsal root ganglia.
GABAB1 and GABAB2 receptor subunits co-expressed in cultured human RPE cells regulate intracellular Ca2+ via Gi/o-protein and phospholipase C pathways.
GABAergic transmission to gonadotropin-releasing hormone (GnRH) neurons is regulated by GnRH in a concentration-dependent manner engaging multiple signaling pathways.
Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression.
Gadolinium inhibits prostate cancer PC3 cell migration and suppresses osteoclast differentiation in vitro.
Galanin activates an inwardly rectifying potassium conductance and inhibits a voltage-dependent calcium conductance in mudpuppy parasympathetic neurons.
Galanin activates nucleotide-dependent K+ channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein.
Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells: activation of the extracellular signal regulated kinase pathway and induction of cyclin-dependent kinase inhibitors.
Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase.
Galanin induces opposite effects via different intracellular pathways in smooth muscle cells from dog colon.
Galanin inhibition of enteric cholinergic neurotransmission: guanosine triphosphate-binding protein interactions with adenylate cyclase.
Galanin inhibition of enterochromaffin-like cell function.
Galanin inhibits dopamine secretion and activates a potassium channel in pheochromocytoma cells.
Galanin inhibits glucagon-like peptide-1 secretion through pertussis toxin-sensitive G protein and ATP-dependent potassium channels in rat ileal L-cells.
Galanin inhibits insulin secretion by direct interference with exocytosis.
Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells.
Galanin inhibits somatostatin release by the rat islet cell tumor in culture, Rin-m.
Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neurons.
Galanin receptor 2 utilizes distinct signaling pathways to suppress cell proliferation and induce apoptosis in HNSCC.
Galanin receptor in the rat pancreatic beta cell line Rin m 5F. Molecular characterization by chemical cross-linking.
Galanin stimulates Ca2+ mobilization, inositol phosphate accumulation, and clonal growth in small cell lung cancer cells.
Galanin stimulates cortisol secretion from human adrenocortical cells through the activation of galanin receptor subtype 1 coupled to the adenylate cyclase-dependent signaling cascade.
Galanin suppresses calcium conductance and activates inwardly rectifying potassium channels in myenteric neurones from guinea-pig small intestine.
Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a Pertussis toxin sensitive pathway.
Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction.
Galectin-3 stimulates uptake of extracellular Ca2+ in human Jurkat T-cells.
Galparan induces in vivo acetylcholine release in the frontal cortex.
Galparan: a powerful insulin-releasing chimeric peptide acting at a novel site.
Galpha i2 enhances in vivo activation of and insulin signaling to GLUT4.
Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy.
Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B.
Galpha(i2), Galpha(i3)and Galpha(o) are all required for normal muscarinic inhibition of the cardiac calcium channels in nodal/atrial-like cultured cardiocytes.
Galpha(q/11) and gbetagamma proteins and membrane signaling of calcitriol and estradiol.
Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac.
Galphai is not required for chemotaxis mediated by Gi-coupled receptors.
Galphai protein-dependant extracellular signal-regulated kinase-1/2 activation is required for HIV-1 reverse transcription.
GalphaL1 (Galpha14) couples the opioid receptor-like1 receptor to stimulation of phospholipase C.
Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart.
Gamma aminobutyric acid B receptor-mediated inhibition of adenylate cyclase in cultured cerebellar granule cells: blockade by islet-activating protein.
gamma-aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes.
gamma-Aminobutyric acid-B receptors inhibit glutamate release from cerebellar granule cells: consequences of inhibiting cyclic AMP formation and calcium influx.
gamma-Hydroxybutyrate receptor binding in rat brain is inhibited by guanyl nucleotides and pertussis toxin.
Ganglioside modulation of neural cell adhesion molecule and N-cadherin-dependent neurite outgrowth.
Gangliosides GM1 and GM2 induce vascular smooth muscle cell proliferation via extracellular signal-regulated kinase 1/2 pathway.
Gap junction assembly: PTX-sensitive G proteins regulate the distribution of connexin43 within cells.
GAP-43 amino terminal peptides modulate growth cone morphology and neurite outgrowth.
Gastric somatostatin: a paracrine regulator of acid secretion.
Gastrin induces IP3 formation through phospholipase C gamma 1 and pp60c-src kinase.
Gastrin stimulation of histamine synthesis in enterochromaffin-like cells from rabbit fundic mucosa.
Gastrin-releasing peptide-induced expression of prostaglandin synthase-2 in Swiss 3T3 cells.
Gating properties of GIRK channels activated by Galpha(o)- and Galpha(i)-coupled muscarinic m2 receptors in Xenopus oocytes: the role of receptor precoupling in RGS modulation.
Gbeta gamma -independent constitutive association of Galpha s with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-1.
Gbeta gamma mediate differentiation of vascular smooth muscle cells.
Gbetagamma dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells.
Gbetagamma signaling promotes breast cancer cell migration and invasion.
Gbetagamma-activated inwardly rectifying K(+) (GIRK) channel activation kinetics via Galphai and Galphao-coupled receptors are determined by Galpha-specific interdomain interactions that affect GDP release rates.
Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy.
GCP-2-induced internalization of IL-8 receptors: hierarchical relationships between GCP-2 and other ELR(+)-CXC chemokines and mechanisms regulating CXCR2 internalization and recycling.
Gene Polymorphism in Toll-like Receptor 4: Effect on Antibody Production and Persistence After Acellular Pertussis Vaccination During Adolescence.
Gene replacement in Bordetella pertussis by transformation with linear DNA.
Generation of a constitutive Na+-dependent inward-rectifier current in rat adult atrial myocytes by overexpression of Kir3.4.
Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccines.
Generation of human monoclonal antibodies that confer protection against pertussis toxin.
Generation of inositol phosphates in bitter taste transduction.
Generation of inositol phosphates, cytosolic Ca2+, and ionic fluxes in PC12 cells treated with bradykinin.
Generation of plant-derived recombinant DTP subunit vaccine.
Genes coding for proteins in central nervous system myelin.
Genes for two homologous G-protein alpha subunits map to different human chromosomes.
Genetic analysis of a region of the Bordetella pertussis chromosome encoding filamentous hemagglutinin and the pleiotropic regulatory locus vir.
Genetic analysis of Bordetella pertussis in Ontario, Canada reveals one predominant clone.
Genetic analysis of pertussis toxin promoter activation in Bordetella pertussis.
Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints.
Genetic and antigenic analysis of Bordetella pertussis isolates recovered from clinical cases in Ontario, Canada, before and after the introduction of the acellular pertussis vaccine.
Genetic and biochemical analyses of BvgA interaction with the secondary binding region of the fha promoter of Bordetella pertussis.
Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis.
Genetic disruption of G proteins, G(i2)alpha or G(o)alpha, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium.
Genetic diversity and population dynamics of Bordetella pertussis in China between 1950-2007.
Genetic exchange of the S2 and S3 subunits in pertussis toxin.
Genetic stability of the live attenuated Bordetella pertussis vaccine candidate BPZE1.
Genetic studies of the molecular basis of whooping cough.
Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response.
Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice.
Genetic Variation of Bordetella pertussis in Austria.
Genetically derived toxoids for use as vaccines and adjuvants.
Genetically detoxified pertussis toxin (PT-9K/129G): implications for immunization and vaccines.
Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity.
Genetically detoxified pertussis toxin induces superior antigen specific CD4 T cell responses compared to chemically detoxified pertussis toxin.
Genetically detoxified pertussis toxin induces Th1/Th17 immune response through MAPKs and IL-10-dependent mechanisms.
Genetically modified pertussis toxin: a quantum leap?
Genetics of pertussis toxin.
Genital antibody responses in mice after intranasal infection with an attenuated candidate vector strain of Bordetella pertussis.
Genome diversity and evolutionary characteristics of clinical isolates of Bordetella pertussis circulating in Iran.
Genome-Wide Association Mapping of the Antibody Response to Diphtheria, Tetanus and Acellular Pertussis Vaccine in Mice.
Genome-wide gene expression analysis of Bordetella pertussis isolates associated with a resurgence in pertussis: elucidation of factors involved in the increased fitness of epidemic strains.
Genomic dissection of Australian Bordetella pertussis isolates from the 2008-2012 epidemic.
Genomics of Bordetella pertussis toxins.
Genotypic variation in the Bordetella pertussis virulence factors pertactin and pertussis toxin in historical and recent clinical isolates in the United Kingdom.
Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues.
Ghrelin Attenuates Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis Involving NLRP3 Inflammasome Signaling Pathway and Pyroptosis.
Ghrelin signaling in human mesenteric arteries.
Ghrelin signalling in guinea-pig femoral artery smooth muscle cells.
Ghrelin suppresses Purkinje neuron P-type Ca(2+) channels via growth hormone secretagogue type 1a receptor, the ?? subunits of Go-protein, and protein kinase a pathway.
Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin.
Gi affects the agonist-binding properties of beta-adrenoceptors in the presence of Gs.
Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.
Gi alpha and Gi beta are part of a signalling complex in Balb/c3T3 cells: phosphorylation of Gi beta in growth-factor-activated fibroblasts.
Gi and Gq/11 proteins are involved in dissemination of myeloid leukemia cells to the liver and spleen, whereas bone marrow colonization involves Gq/11 but not Gi.
Gi is involved in ethanol inhibition of L-type calcium channels in undifferentiated but not differentiated PC-12 cells.
Gi protein activation of gonadotropin-releasing hormone-mediated protein dephosphorylation in human endometrial carcinoma.
Gi protein mediates adenylate cyclase inhibition by neurohypophyseal hormones in fish gill.
Gi protein-mediated translocation of serine/threonine phosphatase to the plasma membrane and apoptosis of ovarian cancer cell in response to gonadotropin-releasing hormone antagonist cetrorelix.
Gi proteins and calcium in dynorphin-induced hypothermia and behaviour.
Gi proteins regulate adenylyl cyclase activity independent of receptor activation.
Gi proteins regulate lipopolysaccharide and Staphylococcus aureus induced cytokine production but not (1--> 3)-beta-D-glucan induced cytokine suppression.
Gi proteins use a novel beta gamma- and Ras-independent pathway to activate extracellular signal-regulated kinase and mobilize AP-1 transcription factors in Jurkat T lymphocytes.
Gi- and protein kinase C-mediated heterologous potentiation of phospholipase C signaling by G protein-coupled receptors.
Gi-coupled GABAB Receptors Cross-Regulate Phospholipase C and Calcium in Airway Smooth Muscle.
Gi-coupled P2Y-ADP receptor mediates GSK-3 phosphorylation and beta-catenin nuclear translocation in granule neurons.
Gi-dependent cell signaling responses of the human P2Y14-receptor in model cell systems.
Gi-mediated activation of mitogen-activated protein kinase (MAPK) pathway by receptor mimetic basic secretagogues of connective tissue-type mast cells: bifurcation of arachidonic acid-induced release upstream of MAPK.
Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.
Gi-mediated activation of the p42/p44 mitogen-activated protein kinases by receptor mimetic basic secretagogues is abrogated by inhibitors of endocytosis.
Gi-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc.
Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase.
Gi-mediated tyrosine phosphorylation of Grb2 (growth-factor-receptor-bound protein 2)-bound dynamin-II by lysophosphatidic acid.
Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming.
Gi/Go couple met-enkephalin to inhibition of cholinergic and beta-adrenergic stimulation of lacrimal secretion.
Gi2 and Gi3 proteins mediate the inhibition of adenylyl cyclase by galanin in the RINm5F cell.
Gi2 and protein kinase C are required for thyrotropin-releasing hormone-induced stimulation of voltage-dependent Ca2+ channels in rat pituitary GH3 cells.
Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells.
Gi2 signaling enhances proliferation of neural progenitor cells in the developing brain.
Gi2-mediated activation of the MAP kinase cascade.
Gialpha3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event.
Ginseng and ginsenoside Rg3, a newly identified active ingredient of ginseng, modulate Ca2+ channel currents in rat sensory neurons.
Ginseng root extract inhibits calcium channels in rat sensory neurons through a similar path, but different receptor, as mu-type opioids.
Ginsenoside Rb1 Enhances Keratinocyte Migration by a Sphingosine-1-Phosphate-Dependent Mechanism.
Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells.
Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity.
GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation.
GIPC participates in G protein signaling downstream of insulin-like growth factor 1 receptor.
Glial receptors and their intervention in astrocyto-astrocytic and astrocyto-neuronal interactions.
Glicentin and oxyntomodulin modulate both the phosphoinositide and cyclic adenosine monophosphate signaling pathways in gastric myocytes.
Global population structure and evolution of Bordetella pertussis and their relationship with vaccination.
GLP-1-(7-36) amide, -(1-37), and -(1-36) amide: potent cAMP-dependent stimuli of rat parietal cell function.
Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon.
Glucagon increases contractility in ventricle but not in atrium of the rat heart.
Glucagon receptor mediates calcium signaling by coupling to G alpha q/11 and G alpha i/o in HEK293 cells.
Glucagon release is regulated by tyrosine phosphatase and PI3-kinase activity.
Glucagon-(19-29) exerts a biphasic action on the liver plasma membrane Ca2+ pump which is mediated by G proteins.
Glucagon-induced heterologous desensitization of the MDCK cell adenylyl cyclase. Increases in the apparent levels of the inhibitory regulator (Ni).
Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes.
Glucagon-mediated Ca2+ signaling in BHK cells expressing cloned human glucagon receptors.
Glucocorticoid receptor activation leads to up-regulation of adenosine A1 receptors and down-regulation of adenosine A2 responses in DDT1 MF-2 smooth muscle cells.
Glucocorticoid treatment reduces prostacyclin synthesis in response to limited stimuli.
Glucocorticoids and dopamine-1 receptors on vascular smooth muscle cells.
Glucose activates the carboxyl methylation of gamma subunits of trimeric GTP-binding proteins in pancreatic beta cells. Modulation in vivo by calcium, GTP, and pertussis toxin.
Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets.
Glucose regulates the expression of Gi-proteins in cultured BC3H-1 myocytes.
Glucose sensing in the intestinal epithelium.
Glucose stimulates islet beta-cell mitogenesis through GTP-binding proteins and by protein kinase C-dependent mechanisms.
Glucose transport stimulation by bradykinin in Swiss 3T3 fibroblasts: a pertussis toxin-sensitive mechanism operates without involvement of arachidonic acid and cyclic AMP.
Glucose uptake by C6 glioma cells is mediated by G(q alpha).
GluK1 inhibits calcium dependent and independent transmitter release at associational/commissural synapses in area CA3 of the hippocampus.
Glutamate activates a K+ conductance increase in Aplysia neurons that appears to be independent of G proteins.
Glutamate elicits an outward K+ current which is normally suppressed by a Ca2+/calmodulin-dependent protein kinase II.
Glutamate inhibits adenylate cyclase activity in dispersed rat hippocampal cells directly via an N-methyl-D-aspartate-like metabotropic receptor.
Glutamate metabotropic receptor inhibition of voltage-gated calcium currents in visceral sensory neurons.
Glutamate receptors activate Ca2+ mobilization and Ca2+ influx into astrocytes.
Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex.
Glutamate stimulates the phosphorylation of glial fibrillary acidic protein in slices of immature rat hippocampus via a metabotropic receptor.
Glutamate-induced swelling of single astroglial cells in primary culture.
Glutamate-stimulated activation of DNA synthesis via mitogen-activated protein kinase in primary astrocytes: involvement of protein kinase C and related adhesion focal tyrosine kinase.
Glutaraldehyde in whole-cell Bordetella pertussis vaccine.
Glutaraldehyde inactivated pertussis vaccine: a less histamine sensitizing vaccine.
Glutathione-induced enhancement of neutrophil locomotion.
Glycochenodeoxycholic acid promotes proliferation of intestinal epithelia via reduction of cyclic AMP and increase in H2AX phosphorylation after exposure to ?-rays.
Glycogenolytic and antiglycogenolytic prostaglandin E2 actions in rat hepatocytes are mediated via different signalling pathways.
GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain.
GnRH-associated peptide decreases cyclic AMP accumulation in the GH3 pituitary cell line.
Go contributes to olfactory reception in Drosophila melanogaster.
Go G-proteins mediate rapid heterologous desensitization of G-protein coupled receptors in Xenopus oocytes.
Go is required for the release of IL-8 and TNF-?, but not degranulation in human mast cells.
Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems.
Go, a major brain GTP binding protein in search of a function: purification, immunological and biochemical characteristics.
Gonadotropin-releasing hormone (GnRH)-receptor coupling to inositol phosphate and prolactin production in GH3 cells stably transfected with rat GnRH receptor complementary deoxyribonucleic acid.
Gonadotropin-releasing hormone activates a rapid Ca2+-independent phosphodiester hydrolysis of polyphosphoinositides in pituitary gonadotrophs.
Gonadotropin-releasing hormone receptor couples to multiple G proteins in rat gonadotrophs and in GGH3 cells: evidence from palmitoylation and overexpression of G proteins.
gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5.
Gp120-induced Bob/GPR15 activation: a possible cause of human immunodeficiency virus enteropathy.
GP55 inhibits both cell adhesion and growth of neurons, but not non-neuronal cells, via a G-protein-coupled receptor.
GPR35 is a functional receptor in rat dorsal root ganglion neurons.
GPR55 and the vascular receptors for cannabinoids.
GPRC6A Mediates Responses to Osteocalcin in ?-Cells In Vitro and Pancreas In Vivo.
Gq/11-coupled receptors and protein synthesis in rat cardiomyocytes: role of Gi-proteins and protein kinase C-isozymes.
Graded G-protein uncoupling by pertussis toxin treatment of human polymorphonuclear leukocytes.
Granulocyte colony-stimulating factor promotes adhesion of neutrophils.
Granulocyte-macrophage colony stimulating factor activates proteoglycan, type II collagen, and cAMP production by rat articular chondrocytes through specific binding sites.
Granulocyte-macrophage colony-stimulating factor and human neutrophils: role of guanine nucleotide regulatory proteins.
Granulocyte-macrophage colony-stimulating factor DNA prime-protein boost strategy to enhance efficacy of a recombinant pertussis DNA vaccine.
Granulocyte-macrophage colony-stimulating factor induces human melanoma-cell migration.
Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover.
Granulocyte-macrophage colony-stimulating factor primes phospholipase D activity in human neutrophils in vitro: role of calcium, G-proteins and tyrosine kinases.
Granulysin, a cytolytic molecule, is also a chemoattractant and proinflammatory activator.
Granzyme B mediates neurotoxicity through a G-protein-coupled receptor.
GRIN1 regulates mu-opioid receptor activities by tethering the receptor and G protein in the lipid raft.
GRK2 contributes to glucose mediated calcium responses and insulin secretion in pancreatic islet cells.
GRK2-mediated trans-phosphorylation contributes to the loss of function of mu opioid receptors induced by neuropeptide FF (NPFF2) receptors.
GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization.
GRO is Chemotactic for Human Intestinal Intraepithelial Lymphocytes.
Group 1 mGlu receptors elevate [Ca2+]i in rat cultured cortical type 2 astrocytes: [Ca2+]i synergy with adenosine A1 receptors.
Group I secreted PLA2 and arachidonic acid metabolites in the maintenance of cat LES tone.
Group I secreted PLA2 in the maintenance of human lower esophageal sphincter tone.
Group-I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal-regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways.
Growth and cell cycle abnormalities of fibroblasts from Tangier disease patients.
Growth and protein phosphorylation in the Nb2 lymphoma: effect of prolactin, cAMP, and agents that activate adenylate cyclase.
Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes.
Growth factor-induced cell division is paralleled by translocation of Gi alpha to the nucleus.
Growth factor-like action of lysophosphatidic acid on human B lymphoblasts.
Growth factor-like action of lysophosphatidic acid: mitogenic signalling mediated by G proteins.
Growth factors, signaling pathways, and the regulation of proliferation and differentiation in BC3H1 muscle cells. I. A pertussis toxin-sensitive pathway is involved.
Growth factors, signaling pathways, and the regulation of proliferation and differentiation in BC3H1 muscle cells. II. Two signaling pathways distinguished by pertussis toxin and a potential role for the ras oncogene.
Growth hormone and dexamethasone stimulate lipolysis and activate adenylyl cyclase in rat adipocytes by selectively shifting Gi alpha2 to lower density membrane fractions.
Growth hormone inhibits activation of phosphatidylinositol phospholipase C in adipose plasma membranes: evidence for a growth hormone-induced change in G protein function.
Growth hormone-induced diacylglycerol and ceramide formation via Galpha i3 and Gbeta gamma in GH4 pituitary cells. Potentiation by dopamine-D2 receptor activation.
Growth regulation of multi-factor-dependent myeloid cell lines: IL-4, TGF-beta and pertussis toxin modulate IL-3- or GM-CSF-induced growth by controlling cell cycle length.
Growth regulation of primary human keratinocytes by prostaglandin E receptor EP2 and EP3 subtypes.
Growth response of human coronary smooth muscle cells to angiotensin II and influence of angiotensin AT1 receptor blockade.
Growth responses to angiotensin II in bovine adrenal glomerulosa cells.
Growth-inhibitory effect of a streptococcal antitumor glycoprotein on human epidermoid carcinoma A431 cells: involvement of dephosphorylation of epidermal growth factor receptor.
Gs and Gi coupling of adrenomedullin in adult rat ventricular myocytes.
Gs and Gq/11 couple vasoactive intestinal peptide and cholinergic stimulation to lacrimal secretion.
GTP analogues promote release of the alpha subunit of the guanine nucleotide binding protein, Gi2, from membranes of rat glioma C6 BU1 cells.
GTP binding regulatory proteins of adenylate cyclase in Schistosoma mansoni at different stages of development.
GTP gamma S causes contraction of skinned frog skeletal muscle via the DHP-sensitive Ca2+ channels of sealed T-tubules.
GTP gamma S increases thrombin-mediated inositol trisphosphate accumulation in permeabilized human endothelial cells.
GTP gamma S-induced solubilization of actin and myosin from rabbit peritoneal neutrophil membrane.
GTP-binding protein couples with metabotropic glutamate receptor in bovine retinal on-bipolar cell.
GTP-binding protein G alpha Z: its down-regulation by dexamethasone and its credentials as a mediator of antigen-induced responses in RBL-2H3 cells.
GTP-binding protein gamma12 subunit phosphorylation by protein kinase C--identification of the phosphorylation site and factors involved in cultured cells and rat tissues in vivo.
GTP-binding protein involvement in membrane currents evoked by carbachol and histamine in guinea-pig ileal muscle.
GTP-binding protein mediated phospholipase A2 activation in rat liver during the progression of sepsis.
GTP-binding proteins and adenylate cyclase activity in v-Ki-ras transformed NIH/3T3 fibroblast cells.
GTP-binding proteins associated with serotonin-activated adenylate cyclase in Fasciola hepatica.
GTP-binding proteins associated with the human placental syncytiotrophoblast plasma membrane.
GTP-binding proteins Gi and Go transplanted onto Xenopus oocyte by rat brain messenger RNA.
GTP-binding proteins in a cyanobacterium Anabaena cylindrica.
GTP-binding proteins in bovine brain nuclear membranes.
GTP-binding proteins in etiolated epicotyls of Pisum sativum (Alaska) seedlings.
GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin.
GTP-binding proteins in luminal and basolateral membranes from pars convoluta and pars recta of rabbit kidney proximal tubule.
GTP-binding proteins inhibit cAMP activation of chloride channels in cystic fibrosis airway epithelial cells.
GTP-binding proteins mediate acetylcholine inhibition of voltage dependent calcium channels in hippocampal neurons.
GTP-binding proteins mediate noradrenaline effects on calcium and chloride currents in rat portal vein myocytes.
GTP-binding proteins mediate the M2-muscarinic effect on the action potential in isolated sympathetic neurons of rabbits.
GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels.
GTP-binding proteins regulate high conductance anion channels in rat bile duct epithelial cells.
GTP-binding proteins transduce signals generated via human FC gamma receptor IIIA (CD16).
GTP-dependent hydrolysis of phosphatidylinositol-4,5-bisphosphate by soluble phospholipase C from adult human epidermis.
GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. Lack of correlation between insulin secretion and cyclic AMP levels.
GTPgammaS-induced actin polymerisation in vitro: ATP- and phosphoinositide-independent signalling via Rho-family proteins and a plasma membrane-associated guanine nucleotide exchange factor.
GTP[S] stimulates migration of electropermeabilized neutrophils via a pertussis toxin-sensitive G-protein.
Guanine nucleotide activation and inhibition of adenylate cyclase as modified by islet-activating protein, pertussis toxin, in mouse 3T3 fibroblasts.
Guanine nucleotide binding protein involvement in early steps of phytochrome-regulated gene expression.
Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors.
Guanine nucleotide binding proteins in cultured renal epithelia: studies with pertussis toxin and aldosterone.
Guanine nucleotide binding proteins in opioid-dependent patients.
Guanine nucleotide binding proteins in the dual regulation of lacrimal function.
Guanine nucleotide binding proteins mediate D2 dopamine receptor activation of a potassium channel in rat lactotrophs.
Guanine nucleotide binding proteins mediate the chemotactic signal of transforming growth factor-beta 1 in rat IL-2 activated natural killer cells.
Guanine nucleotide effects on catecholamine secretion from digitonin-permeabilized adrenal chromaffin cells.
Guanine nucleotide regulation of phospholipase C activity in permeabilized rabbit neutrophils. Inhibition by pertussis toxin and sensitization to submicromolar calcium concentrations.
Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells.
Guanine nucleotide regulatory proteins, Gq and Gi1/2, mediate platelet-activating factor-stimulated phosphoinositide metabolism in immortalized hippocampal cells.
Guanine nucleotide- and muscarinic agonist-dependent phosphoinositide metabolism in synaptoneurosomes from cerebral cortex of immature rats.
Guanine nucleotide-binding inhibitory protein-mediated inhibition of adenylyl cyclase is enhanced in spontaneously hypertensive rat preglomerular arteriolar smooth muscle cells.
Guanine nucleotide-binding protein Go-induced coupling of neuropeptide Y receptors to Ca2+ channels in sensory neurons.
Guanine nucleotide-binding protein in sea urchin eggs serving as the specific substrate of islet-activating protein, pertussis toxin.
Guanine nucleotide-binding protein regulation of microsomal phospholipase D activity of canine cerebral cortex.
Guanine nucleotide-binding protein, alpha i-3, directly activates a cation channel in rat renal inner medullary collecting duct cells.
Guanine nucleotide-binding proteins involved in transmembrane signaling.
Guanine nucleotide-binding proteins modulate desmethoxyverapamil binding to calcium channels in vascular smooth muscle.
Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.
Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells.
Guanine nucleotide-dependent, pertussis toxin-insensitive regulation of phosphoinositide turnover by bradykinin in bovine pulmonary artery endothelial cells.
Guanine nucleotide-induced polymerization of actin in electropermeabilized human neutrophils.
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.
Guanine nucleotides and pertussis toxin alter agonist binding to rat septal V(1)-vasopressin receptors.
Guanine nucleotides and pertussis toxin reduce the affinity of histamine H3 receptors on AtT-20 cells.
Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.
Guanine nucleotides inhibit poly-L-arginine-induced membrane damage in polymorphonuclear leukocytes.
Guanine nucleotides reduce the free calcium requirement for secretion of granule constituents from permeabilized human neutrophils.
Guanine-induced inhibition of renal Na(+)-ATPase activity: Evidence for the involvement of the Gi protein-coupled receptor.
Guanine-nucleotide-binding proteins Gi and Gs in fat-cells from normal, hypothyroid and obese human subjects.
Guanosine 5'-(gamma-thio) triphosphate (GTP gamma S) inhibits phosphorylation of insulin receptor and a novel GTP-binding protein, Gir, from human placenta.
Guanosine 5'-O-(3-thiotriphosphate) and cations regulate melatonin receptors, and melatonin inhibits cyclic AMP production in the spinal cord.
Guanosine 5'-O-(3-thiotriphosphate) and guanosine 5'-O-(2-thiodiphosphate) activate G proteins and potentiate fibroblast growth factor-induced DNA synthesis in hamster fibroblasts.
Guanosine 5'-O-(3-thiotriphosphate) causes endothelium-dependent, pertussis toxin-sensitive relaxations in porcine coronary arteries.
Guanosine 5'-O-(3-thiotriphosphate) reduces ADP-ribosylation of the inhibitory guanine nucleotide-binding regulatory protein of adenylyl cyclase (Ni) by pertussis toxin without causing dissociation of the subunits of Ni. Evidence of existence of heterotrimeric pt+ and pt- conformations of Ni.
Guanosine 5'-O-(3-thiotrisphosphate) potentiates both thrombin- and platelet-derived growth factor-induced inositol phosphate release in permeabilized vascular smooth muscle cells. Signaling mechanisms distinguished by sensitivity to pertussis toxin and phorbol esters.
Guanosine 5'-triphosphate binding protein (Gi) and two additional pertussis toxin substrates associated with muscarinic receptors in rat heart myocytes: characterization and age dependency.
Guanosine triphosphate can directly regulate cortisol production by activating Ca(2+)-messenger systems in bovine adrenal fasciculata cells.
Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells.
Guidance of CNS growth cones by substratum grooves and ridges: effects of inhibitors of the cytoskeleton, calcium channels and signal transduction pathways.
Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4.
Guinea pig hepatocyte alpha 1A-adrenoceptors: characterization, signal transduction and regulation.
Guinea pig histamine H1 receptor. II. Stable expression in Chinese hamster ovary cells reveals the interaction with three major signal transduction pathways.
Guinea-pig treatment with pertussis toxin suppresses macrophage-dependent bronchoconstriction by fMLP and fails to inhibit the effects of PAF.
Gx/z and Gi2 transducer proteins on mu/delta opioid-mediated supraspinal antinociception.
Gz coupling to the rat kappa-opioid receptor.
Gz, a guanine nucleotide-binding protein with unique biochemical properties.
Gz- and not Gi-proteins are coupled to pre-junctional ?-opioid receptors in bovine airways.
Gz-mediated hormonal inhibition of cyclic AMP accumulation.
Göttingen Minipigs as a Model to Evaluate Longevity, Functionality, and Memory of Immune Response Induced by Pertussis Vaccines.
H-Ras signals to cytoskeletal machinery in induction of integrin-mediated adhesion of T cells.
H1-histamine receptors on human astrocytoma cells.
H3 autoreceptors modulate histamine synthesis through calcium/calmodulin- and cAMP-dependent protein kinase pathways.
H3 receptor-mediated inhibition of intestinal acetylcholine release: pharmacological characterization of signal transduction pathways.
Haemodynamic characterization of young normotensive men carrying the 825T-allele of the G-protein beta3 subunit.
Halothane and pertussis toxin-sensitive G proteins in airway smooth muscle.
Halothane inhibits bradykinin-stimulated prostacyclin production in endothelial cells.
Halothane inhibits spontaneous calcium oscillations via adenosine A1 receptors.
Halothane interaction with guanine nucleotide binding proteins in mouse heart.
Halothane myocardial depression: interactions with the adenylate cyclase system.
HDL and sphingosine-1-phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion.
Head-activator induced mitosis of NH15-CA2 cells requires calcium influx and hyperpolarization.
Heart contains two substrates (Mr = 40,000 and 41,000) for pertussis toxin-catalyzed ADP-ribosylation that co-purify with Ns.
Heart/Cardiac Muscle: Cocaine- and amphetamine-regulated transcript (CART) peptide as an in vivo regulator of cardiac function in Rana ridibunda frog.
Heat shock increases cytosolic free Ca2+ concentration via Na(+)-Ca2+ exchange in human epidermoid A 431 cells.
Heat stress stimulates high affinity GTPase in cervical carcinoma cells.
Heat treatment induces an increase in intracellular cyclic AMP content in human epidermoid A-431 cells.
Heat-aggregated IgA prepared from patients with IgA nephropathy increases priming of human neutrophils to produce inositol triphosphate following FMet-Leu-Phe stimulation in vitro.
Helicobacter pylori neutrophil-activating protein induces release of histamine and interleukin-6 through G protein-mediated MAPKs and PI3K/Akt pathways in HMC-1 cells.
Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells.
Helicobacter pylori-induced prostaglandin E(2) synthesis involves activation of cytosolic phospholipase A(2) in epithelial cells.
Helminth-conditioned dendritic cells prime CD4+ T cells to IL-4 production in vivo.
Hemagglutination activities of purified pertussis toxin and filamentous hemagglutinin against erythrocytes from various animals.
Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors.
Hemoglobin causes release of inositol trisphosphate from vascular smooth muscle.
Hemolysis induced by Bacillus cereus sphingomyelinase.
Hemolytically inactive C5b67 complex: an agonist of polymorphonuclear leukocytes.
Heparan sulfate proteoglycan on endothelium efficiently induces integrin-mediated T cell adhesion by immobilizing chemokines in patients with rheumatoid synovitis.
Hepoxilin A3 induces changes in cytosolic calcium, intracellular pH and membrane potential in human neutrophils.
Hesperidin, a Citrus Flavonoid, Has the Ameliorative Effects Against Experimental Autoimmune Encephalomyelitis (EAE) in a C57BL/J6 Mouse Model.
Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions.
Heterogeneity of angiotensin II AT2 receptors in the rat brain.
Heterogeneity of ATP receptors in aortic endothelial cells. Involvement of P2y and P2u receptors in inositol phosphate response.
Heterogeneity of P2u- and P2y-purinergic receptor regulation of phospholipases in MDCK cells.
Heterogeneity of the motility responses in malignant tumor cells: a biological basis for the diversity and homing of metastatic cells.
Heterologous desensitization and reduced G protein ADP-ribosylation following exposure to alpha 2-adrenoceptor and muscarinic receptor agonists.
Heterologous desensitization of adenylate cyclase with prostaglandin E1 alters sensitivity to inhibitory as well as stimulatory agonists.
Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes. Regulation of both Ns and Ni.
Heterologous desensitization of the liver adenylyl cyclase: analysis of the role of G-proteins.
Heterologous expression and coupling of G protein-gated inwardly rectifying K+ channels in adult rat sympathetic neurons.
Heterologous expression of a green fluorescent protein-pertussis toxin S1 subunit fusion construct disrupts calcium channel modulation in rat superior cervical ganglion neurons.
Heterologous regulations of cAMP responses in pregnant rat myometrium. Evolution from a stimulatory to an inhibitory prostaglandin E2 and prostacyclin effect.
Heteromeric association creates a P2Y-like adenosine receptor.
Heterotrimeric G protein activation rapidly inhibits outgrowth of optic axons from adult and embryonic mouse, and goldfish retinal explants.
Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.
Heterotrimeric G protein Gi is involved in a signal transduction pathway for ATP release from erythrocytes.
Heterotrimeric G proteins and the platelet-derived growth factor receptor-beta contribute to hypoxic proliferation of smooth muscle cells.
Heterotrimeric G proteins are implicated in gibberellin induction of a-amylase gene expression in wild oat aleurone
Heterotrimeric G proteins containing G alpha i3 regulate multiple effector enzymes in the same cell. Activation of phospholipases C and A2 and inhibition of adenylyl cyclase.
Heterotrimeric G-protein and signal transduction in the nematode-trapping fungus Arthrobotrys dactyloides.
Heterotrimeric G-protein candidates for Ge in the ACTH secretory pathway.
Heterotrimeric G-proteins activate Cl- channels through stimulation of a cyclooxygenase-dependent pathway in a model liver cell line.
Heterotrimeric G-proteins are implicated in the regulation of apoptosis in pancreatic beta-cells.
Heterotrimeric G?(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis.
Heterotrimeric Gi protein is associated with the inositol 1,4,5-trisphosphate receptor complex and modulates calcium flux.
Heterotrimeric Gi/Go proteins modulate endothelial TLR signaling independent of the MyD88-dependent pathway.
Heterotrimeric guanosine triphosphate-binding protein-coupled modulatory actions of motilin on K+ channels and postsynaptic ?-aminobutyric acid receptors in mouse medial vestibular nuclear neurons.
Higenamine, a Dual Agonist for ? 1- and ? 2-Adrenergic Receptors Identified by Screening a Traditional Chinese Medicine Library.
High affinity binding of 125I-neurotensin to dispersed cells from chicken liver and brain.
High carbachol increases the electrically induced [Ca2+]i transient in the single isolated ventricular myocyte of rats.
High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells.
High concentrations of adrenergic antagonists prolong sciatic nerve blockade by tetrodotoxin.
High concentrations of histamine stimulate equine polymorphonuclear neutrophils to produce reactive oxygen species.
High constitutive activity of the human formyl peptide receptor.
High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists.
High density lipoprotein-associated lysosphingolipids reduce E-selectin expression in human endothelial cells.
High density lipoprotein-associated sphingosine 1-phosphate promotes endothelial barrier function.
High density lipoprotein-induced angiogenesis requires the activation of Ras/MAP kinase in human coronary artery endothelial cells.
High density lipoprotein-induced signaling of the MAPK pathway involves scavenger receptor type BI-mediated activation of Ras.
High density lipoproteins induce cell cycle entry in vascular smooth muscle cells via mitogen activated protein kinase-dependent pathway.
High dose combination pertussis toxin induces autoimmune inner ear disease in Sprague-Dawley rats.
High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation.
High extracellular calcium attenuates adipogenesis in 3T3-L1 preadipocytes.
High glucose concentration causes a rise in [Ca2+]i of cardiac myocytes.
High glucose inhibits fructose uptake in renal proximal tubule cells: involvement of cAMP, PLC/PKC, p44/42 MAPK, and cPLA2.
High glucose stimulates Ca2+ uptake via cAMP and PLC/PKC pathways in primary cultured renal proximal tubule cells.
HIGH GLUCOSE-INDUCED INHIBITION OF 2-DEOXYGLUCOSE UPTAKE IS MEDIATED BY cAMP, PROTEIN KINASE C, OXIDATIVE STRESS AND MITOGEN-ACTIVATED PROTEIN KINASES IN MOUSE EMBRYONIC STEM CELLS.
High IFN-alpha expression is associated with the induction of experimental autoimmune uveitis (EAU) in Fischer 344 rat.
High levels of antibody in adults three years after vaccination with a reduced antigen content diphtheria-tetanus-acellular pertussis vaccine.
High prevalence of Bordetella pertussis in children under 5 years old hospitalized with acute respiratory infections in Lima, Peru.
High rate of vaccine failure after administration of acellular pertussis vaccine pre- and post-liver transplantation in children at a children's hospital in Japan.
High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate.
High-density lipoprotein increases intracellular calcium levels by releasing calcium from internal stores in human endothelial cells.
High-density lipoprotein induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through sphingosine kinase-2.
High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors.
High-density lipoprotein stimulates endothelial cell movement by a mechanism distinct from basic fibroblast growth factor.
High-glucose incubation of human umbilical-vein endothelial cells does not alter expression and function either of G-protein alpha-subunits or of endothelial NO synthase.
High-intensity p38 kinase activity is critical for p21(cip1) induction and the antiproliferative function of G(i) protein-coupled receptors.
High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists.
Highly sensitive histamine-sensitization test for residual activity of pertussis toxin in acellular pertussis vaccine.
Histamine activates Cl- and K+ currents in guinea-pig tracheal myocytes: convergence with muscarinic signalling pathway.
Histamine activates phospholipase C in human airway epithelial cells via a phorbol ester-sensitive pathway.
Histamine activates phosphorylase and inositol phosphate production in guinea pig hepatocytes.
Histamine and bradykinin stimulate the phosphoinositide turnover in human umbilical vein endothelial cells via different G-proteins.
Histamine H(3) receptor-mediated inhibition of endogenous acetylcholine release from the isolated, vascularly perfused rat stomach.
Histamine H(3) receptors mediate inhibition of noradrenaline release from intestinal sympathetic nerves.
Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells.
Histamine H1 receptors in C6 glial cells are coupled to calcium-dependent potassium channels via release of calcium from internal stores.
Histamine H1-receptor-mediated inositol phospholipid hydrolysis in DDT1MF-2 cells: agonist and antagonist properties.
Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores.
Histamine H1-receptors on astrocytes in primary cultures: a possible target for histaminergic neurones.
Histamine H2 receptor signaling x environment interactions determine susceptibility to experimental allergic encephalomyelitis.
Histamine H3 receptor activation inhibits dopamine D1 receptor-induced cAMP accumulation in rat striatal slices.
Histamine H3-receptor activation augments voltage-dependent Ca2+ current via GTP hydrolysis in rabbit saphenous artery.
Histamine H3-receptor-induced attenuation of norepinephrine exocytosis: a decreased protein kinase a activity mediates a reduction in intracellular calcium.
Histamine H3-receptor-induced inhibition of duodenal cholinergic transmission is independent of intracellular cyclic AMP and GMP.
Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells.
Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue.
Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor.
Histamine modulates high-voltage-activated calcium channels in neurons dissociated from the rat tuberomammillary nucleus.
Histamine provokes turnover of inositol phospholipids in guinea pig and human airway epithelial cells via an H1-receptor/G protein-dependent mechanism.
Histamine receptor-dependent and/or -independent activation of guanine nucleotide-binding proteins by histamine and 2-substituted histamine derivatives in human leukemia (HL-60) and human erythroleukemia (HEL) cells.
Histamine release from basophils in childhood: age dependency and inhibition by pertussis infection and pertussis toxin.
Histamine release, an undesired effect of thrombin inhibitors with basic character, is mediated through direct activation of G(i) proteins.
Histamine stimulates human lung fibroblast migration.
Histamine-induced microvascular leakage in pial venules: differences between the SJL/J and BALB/c inbred strains of mice.
Histamine-stimulated and GTP-binding proteins-mediated phospholipase A2 activation in rabbit platelets.
Histamine-stimulated phospholipase C signalling in the adrenal chromaffin cell: effects on inositol phospholipid metabolism and tyrosine hydroxylase phosphorylation.
Histidine regulation of cyclic AMP metabolism in cultured renal epithelial LLC-PK1 cells.
Histone H4 directly stimulates neutrophil activation through membrane permeabilization.
Histopathological analysis of rat mesentery as a method for evaluating neutrophil migration: differential effects of dexamethasone and pertussis toxin.
History of whooping cough in nonvaccinated Swedish children, related to serum antibodies to pertussis toxin and filamentous hemagglutinin.
HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication.
HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation.
HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling.
HIV-1 Tat protein attenuates the clinical course of experimental autoimmune encephalomyelitis (EAE).
HIV-1 Tat protein mimicry of chemokines.
HIV-1 Tat triggers TGF-beta production and NK cell apoptosis that is prevented by pertussis toxin B.
HIV-specific T cell cytotoxicity mediated by RANTES via the chemokine receptor CCR3.
HL-1 cells express an inwardly rectifying K(+) current activated via muscarinic receptors comparable to that in mouse atrial myocytes.
HOCl production by human neutrophils activated by surface-associated IgG: requirement for influx of extracellular calcium.
Holo-APP and G-protein-mediated signaling are required for sAPP?-induced activation of the Akt survival pathway.
Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons.
Homocysteine effects classical pathway of GPCR down regulation: Galpha(q/11), Galpha (12/13), G (i/o).
Homocysteine inhibits arterial endothelial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation.
Homologous and heterologous beta-adrenergic desensitization in hepatocytes. Additivity and effect of pertussis toxin.
Homologous and heterologous desensitisation of somatostatin-induced increases in intracellular Ca2+ and inositol 1,4,5-trisphosphate in CHO-K1 cells expressing human recombinant somatostatin sst5 receptors.
Homologous and heterologous protection after single intranasal administration of live attenuated recombinant Bordetella pertussis.
Homologous sensitisation of embryonic chick atrial myocytes to adenosine: mediation by adenosine A1 receptor and guanine nucleotide binding protein.
Homotypic lysosome fusion in macrophages: analysis using an in vitro assay.
Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes.
Hormonal regulation of MAP kinase in cultured rat inner medullary collecting tubule cells.
Hormonal regulation of mitogen-activated protein kinase activity in bovine adrenocortical cells: cross-talk between phosphoinositides, adenosine 3',5'-monophosphate, and tyrosine kinase receptor pathways.
Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins.
Hormonal regulation of rat renal proximal tubule brush-border membrane ionic permeability.
Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits.
Hormone-defined cell system for studying G-protein coupled receptor agonist-activated growth modulation: delta-opioid and serotonin-5HT2C receptor activation show opposite mitogenic effects.
Hormone-sensitive adenylate cyclase of prolactin-producing rat pituitary adenoma (GH4C1) cells: molecular organization.
House dust mite allergen activates human eosinophils via formyl peptide receptor and formyl peptide receptor-like 1.
How common is whooping cough in a nonvaccinating country?
How does the G protein, Gi2, transduce mitogenic signals?
How to make sense of pertussis immunogenicity data.
HSP-72 synthesis is promoted by increase in [Ca2+]i or activation of G proteins but not pHi or cAMP.
Human 5-HT1A receptor expressed in insect cells activates endogenous G(o)-like G protein(s).
Human adenosine A1 receptor and P2Y2-purinoceptor-mediated activation of the mitogen-activated protein kinase cascade in transfected CHO cells.
Human airway epithelial monolayers promote selective transmigration of memory T cells: a transepithelial model of lymphocyte migration into the airways.
Human and rat cutaneous mast cells: involvement of a G protein in the response to peptidergic stimuli.
Human angiotensin II type-2 receptor inhibition of insulin-mediated ERK-2 activity via a G-protein coupled signaling pathway.
Human antibody response to the B oligomer of pertussis toxin.
Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1.
Human B cells express the orphan chemokine receptor CRAM-A/B in a maturation-stage-dependent and CCL5-modulated manner.
Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils.
Human bone marrow endothelial cells elaborate non-stromal-cell-derived factor-1 (SDF-1)-dependent chemoattraction and SDF-1-dependent transmigration of haematopoietic progenitors.
Human bronchial epithelial cells express PAR-2 with different sensitivity to thermolysin.
Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes.
Human CC chemokine CCL23, a ligand for CCR1, induces endothelial cell migration and promotes angiogenesis.
Human cellular immune responses to Bordetella pertussis infection.
Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines.
Human chymase stimulates Ca2+ signaling in human polymorphonuclear cells.
Human dendritic cell maturation and cytokine secretion upon stimulation with Bordetella pertussis filamentous haemagglutinin.
Human eosinophils induce histamine release from antigen-activated rat peritoneal mast cells: a possible role for mast cells in late-phase allergic reactions.
Human eotaxin represents a potent activator of the respiratory burst of human eosinophils.
Human epidermoid A431 cells express functional nicotinic acid receptor HM74a.
Human fat cell lipolysis is primarily regulated by inhibitory modulators acting through distinct mechanisms.
Human fetal skin fibroblast migration stimulated by the autocrine growth factor bFGF is mediated by phospholipase A(2) via arachidonic acid without the involvement of pertussis toxin-sensitive G-protein.
Human fractalkine mediates leukocyte adhesion but not capture under physiological shear conditions; a mechanism for selective monocyte recruitment.
Human galectin-3 is a novel chemoattractant for monocytes and macrophages.
Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA.
Human granulocyte-macrophage colony-stimulating factor and other cytokines prime human neutrophils for enhanced arachidonic acid release and leukotriene B4 synthesis.
Human growth hormone increases cytosolic free calcium in cultured human IM-9 lymphocytes: a novel mechanism of growth hormone transmembrane signalling.
Human H9 cells proliferation is differently controlled by vasoactive intestinal peptide or peptide histidine methionine: implication of a GTP-insensitive form of VPAC1 receptor.
Human immunodeficiency virus type 1 Tat and methamphetamine affect the release and activation of matrix-degrading proteinases.
Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.
Human immunodeficiency virus-1 infection requires pertussis toxin sensitive G-protein-coupled signalling and mediates cAMP downregulation.
Human immunodeficiency virus-induced apoptosis of human breast cancer cells via CXCR4 is mediated by the viral envelope protein but does not require CD4.
Human kidney-2 cells harbor functional dopamine D1 receptors that require Gi? for Gq/11? signaling.
Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation.
Human metabotropic glutamate receptor 2 couples to the MAP kinase cascade in chinese hamster ovary cells.
Human monocytes respond to leukotriene B4 with a transient increase in cytosolic calcium.
Human mu-opioid receptor overexpressed in Sf9 insect cells functionally coupled to endogenous Gi/o proteins.
Human neutrophil stimulation by influenza virus: relationship of cytoplasmic pH changes to cell activation.
Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.
Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release.
Human P2Y2 receptor polymorphism: identification and pharmacological characterization of two allelic variants.
Human pancreatic tumor growth hormone (GH) - releasing factor and cyclic adenosine 3',5'- monophosphate evoke GH release from anterior pituitary cells: the effects of pertussis toxin, cholera toxin, forskolin, and cycloheximide.
Human Peptides ?-Defensin-1 and -5 Inhibit Pertussis Toxin.
Human plasmin induces a receptor-mediated arachidonate release coupled with G proteins in endothelial cells.
Human platelets exhibit chemotaxis using functional N-formyl peptide receptors.
Human polymorphonuclear leukocyte activating factor isolated from Aleurites Fordii Hemsl. (Euphorbiaceae) seed.
Human recombinant chromogranin A-derived vasostatin-1 mimics preconditioning via an adenosine/nitric oxide signaling mechanism.
Human recombinant histamine-releasing factor activates human eosinophils and the eosinophilic cell line, AML14-3D10.
Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance.
Human Rhinovirus Infection of Epithelial Cells Modulates Airway Smooth Muscle Migration.
Human Salivary Histatin-1 Promotes Osteogenic Cell Spreading on Both Bio-Inert Substrates and Titanium SLA Surfaces.
Human serum antibody responses to Bordetella pertussis infection and pertussis vaccination.
Human T cell clones define S1 subunit as the most immunogenic moiety of pertussis toxin and determine its epitope map.
Human T lymphocyte mitogenesis in response to the B oligomer of pertussis toxin is associated with an early elevation in cytosolic calcium concentrations.
Humanised monoclonal antibodies neutralise pertussis toxin by receptor blockade and reduced retrograde trafficking.
Humoral and cellular immune responses in mice immunized with recombinant Mycobacterium bovis Bacillus Calmette-Guérin producing a pertussis toxin-tetanus toxin hybrid protein.
Humoral immunity of dTap-IPV vaccine (REPEVAX(®)) administered one month after dT-IPV vaccine (REVAXIS(®)) in adults with unknown vaccination history.
Hydrodynamic properties of adenosine Ri receptors solubilized from rat cerebral-cortical membranes.
Hydrogen peroxide signaling mediates DHEA-induced vascular endothelial cell proliferation.
Hydrophobic binding of pertussis toxin is enhanced by oligosaccharide receptors.
Hydrophobic photolabelling of pertussis toxin subunits interacting with lipids.
Hydrophobicity and subunit interactions of rod outer segment proteins investigated using Triton X-114 phase partitioning.
Hydrophobicity of residue351 of the G protein Gi1 alpha determines the extent of activation by the alpha 2A-adrenoceptor.
Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways.
Hyperactivation of phospholipase C does not support the enhanced proliferation of aortic smooth muscle cells from spontaneously hypertensive rats.
Hyperosmolar solution effects in guinea pig airways. III. Studies on the identity of epithelium-derived relaxing factor in isolated perfused trachea using pharmacological agents.
Hyperpolarization is not responsible for the acetylcholine-induced negative chronotropic action in the presence of isoproterenol.
Hyperpolarizing muscarinic responses of freshly dissociated rat hippocampal CA1 neurones.
Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716.
Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes.
Hypertrophic effect of selective beta(1)-adrenoceptor stimulation on ventricular cardiomyocytes from adult rat.
Hypocretin (orexin) receptor subtypes differentially enhance acetylcholine release and activate g protein subtypes in rat pontine reticular formation.
Hypocretin/orexin suppresses corticotroph responsiveness in vitro.
Hypoglycaemia and acute stress-induced hyperinsulinaemia in mice infected with Bordetella pertussis or treated with pertussis toxin.
Hyposmotic stress causes ATP release and stimulates Na, K-ATPase activity in porcine lens.
Hypothalamic administration of cAMP agonist/PKA activator inhibits both schedule feeding and NPY-induced feeding in rats.
Hypotonic stimulation induced Ca2+ release from IP3-sensitive internal stores in a green monkey kidney cell line.
Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts.
Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular cAMP levels.
Hypoxia-induced Mitogenic Factor/FIZZ1 Induces Intracellular Calcium Release Through the PLC-IP3 Pathway.
Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinases.
Hypoxic preconditioning in isolated rat hearts: non-involvement of activation of adenosine A1 receptor, Gi protein, and ATP-sensitive K+ channel.
I-309/T cell activation gene-3 chemokine protects murine T cell lymphomas against dexamethasone-induced apoptosis.
Idazoxan down-regulates beta-adrenoceptors on C6 glioma cells in vitro.
Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor.
Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8.
Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.
Identification and characterization of autocrine-motility-factor-like activity in oral squamous-cell-carcinoma cells.
Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells.
Identification and characterization of human surfactant protein A binding protein of Mycoplasma pneumoniae.
Identification and characterization of multiple subtypes of muscarinic acetylcholine receptors and their physiological functions in canine hearts.
Identification and characterization of muscarinic receptors potentiating the stimulation of adenylyl cyclase activity by corticotropin-releasing hormone in membranes of rat frontal cortex.
Identification and characterization of P2Y2 nucleotide receptors in human retinal pigment epithelial cells.
Identification and characterization of PtlC, an essential component of the pertussis toxin secretion system.
Identification and characterization of the carbohydrate ligands recognized by pertussis toxin via a glycan microarray and surface plasmon resonance.
Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity.
Identification and Characterization of ZEL-H16 as a Novel Agonist of the Histamine H(3) Receptor.
Identification and functional characterization of adenylate cyclase-linked receptors for parathyroid hormone-like peptides on immortalized human keratinocytes.
Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to inhibition of adenylyl cyclase and stimulation of phospholipase A2.
Identification and partial characterization of genes that are transactivated by different pathways in quiescent mouse cells stimulated with serum.
Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go.
Identification and purification of a novel G protein from neutrophils.
Identification of a 43-kilodalton human T lymphocyte membrane protein as a receptor for pertussis toxin.
Identification of a Bordetella pertussis regulatory factor required for transcription of the pertussis toxin operon in Escherichia coli.
Identification of a botulinum C3-like enzyme in bovine brain that catalyzes ADP-ribosylation of GTP-binding proteins.
Identification of a cis-regulatory element mediating somatostatin inhibition of epidermal growth factor-stimulated gastrin gene transcription.
Identification of a compound that directly stimulates phospholipase C activity.
Identification of a DNA fragment in the genome of Bordetella pertussis carrying repeated DNA sequences also present in other Bordetella species.
Identification of a G protein alpha subunit from Neurospora crassa that is a member of the Gi family.
Identification of a G protein in rough endoplasmic reticulum of canine pancreas.
Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin.
Identification of a guanine nucleotide-binding protein G(o) in human neuroblastoma.
Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.
Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes.
Identification of a neuronal cell surface receptor for a growth inhibitory chondroitin sulfate proteoglycan (NG2).
Identification of a new GTP-binding protein. A Mr = 43,000 substrate for pertussis toxin.
Identification of a novel extracellular cation-sensing G-protein-coupled receptor.
Identification of a novel human eicosanoid receptor coupled to G(i/o).
Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase.
Identification of a potent inverse agonist at a constitutively active mutant of human P2Y12 receptor.
Identification of a potent serum factor that causes desensitization of the receptor for C-Type natriuretic peptide.
Identification of a protein hydrolysate responsive G protein-coupled receptor in enterocytes.
Identification of a region in the S1 subunit of pertussis toxin that is required for enzymatic activity and that contributes to the formation of a neutralizing antigenic determinant.
Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes.
Identification of a structural element in phospholipase C beta2 that interacts with G protein betagamma subunits.
Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C.
Identification of A1 adenosine receptors in rat cochlea coupled to inhibition of adenylyl cyclase.
Identification of alpha-subunits of trimeric GTP-binding proteins in human platelets by RT-PCR.
Identification of amino acid residues essential for the enzymatic activities of pertussis toxin.
Identification of amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1.
Identification of an active-site residue in subunit S1 of pertussis toxin by photocrosslinking to NAD.
Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine.
Identification of an essential signaling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. Possible requirement of Gq-mediated p21ras activation coupled to a Ca2+/calmodulin-sensitive tyrosine kinase.
Identification of B-cell epitopes on the S4 subunit of pertussis toxin.
Identification of B16-F1 melanoma autocrine motility-like factor receptor.
Identification of binding proteins for pertussis toxin on pancreatic beta cell-derived insulin-secreting cells.
Identification of biomarkers to detect residual pertussis toxin using microarray analysis of dendritic cells.
Identification of Bordetella pertussis infection by shared-primer PCR.
Identification of Bphs, an autoimmune disease locus, as histamine receptor H1.
Identification of cannabinoid receptors in cultures of rat cerebellar granule cells.
Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3.
Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.
Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines.
Identification of CXCR4 domains that support coreceptor and chemokine receptor functions.
Identification of distinct signalling pathways for somatostatin receptors SSTR1 and SSTR2 as revealed by microphysiometry.
Identification of endothelin receptors in cultured cerebellar neurons.
Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor.
Identification of G protein subtypes in peripheral nerve and cultured Schwann cells.
Identification of G protein-coupled receptors potently stimulating migration of human transitional-cell carcinoma cells.
Identification of G-protein alpha-subunits during distinct stages of lens cell differentiation.
Identification of G-proteins in rat parotid gland plasma membranes and granule membranes: presence of distinct components in granule membranes.
Identification of gangliosides as inhibitors of ADP-ribosyltransferases of pertussis toxin and exoenzyme C3 from Clostridium botulinum.
Identification of heterotrimeric and low molecular weight GTP-binding proteins in rabbit skeletal muscle longitudinal sarcoplasmic reticulum.
Identification of human neutrophil-derived cathepsin G and azurocidin/CAP37 as chemoattractants for mononuclear cells and neutrophils.
Identification of human T-cell epitopes on the S4 subunit of pertussis toxin.
Identification of linear B-cell determinants of pertussis toxin associated with the receptor recognition site of the S3 subunit.
Identification of murine T-cell epitopes on the S4 subunit of pertussis toxin.
Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors.
Identification of NCAM-binding peptides promoting neurite outgrowth via a heterotrimeric G-protein-coupled pathway.
Identification of neuropeptide Y receptors in cultured astrocytes from neonatal rat brain.
Identification of Novel Competing ?(2)AR Phospho-Extracellular Signal Regulated Kinase 1/2 Signaling Pathways in Human Trabecular Meshwork Cells.
Identification of novel GTP-binding proteins in the human neutrophil.
Identification of novel phytocannabinoids from Ganoderma by label-free dynamic mass redistribution assay.
Identification of novel synthetic peptide showing angiogenic activity in human endothelial cells.
Identification of peptides that mimic the pertussis toxin binding site on bovine fetuin.
Identification of pertussis-specific effector memory T cells in preschool children.
Identification of proteins resembling G-protein alpha subunits in locust muscle.
Identification of Salmonella typhi promoters activated by invasion of eukaryotic cells.
Identification of single C motif-1/lymphotactin receptor XCR1.
Identification of somatostatin receptors by covalent labeling with a novel photoreactive somatostatin analog.
Identification of T- and B-cell epitopes of the S2 and S3 subunits of pertussis toxin by use of synthetic peptides.
Identification of the border between fibronectin type III homologous repeats 2 and 3 of the neural cell adhesion molecule L1 as a neurite outgrowth promoting and signal transducing domain.
Identification of the C3a Receptor (C3AR1) as the Target of the VGF-derived Peptide TLQP-21 in Rodent Cells.
Identification of the functional region on the superantigen Yersinia pseudotuberculosis-derived mitogen responsible for induction of lymphocyte proliferation by using synthetic peptides.
Identification of the G-protein alpha-subunit encoded by alpha o2 cDNA as a 39 kDa pertussis toxin substrate.
Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries.
Identification of the pertussis and cholera toxin substrates in normal and N-ras transformed NIH3T3 fibroblasts and an assessment of their involvement in bombesin-stimulation of inositol phospholipid metabolism.
Identification of the pertussis toxin-sensitive G proteins in platelets, megakaryocytes, and human erythroleukemia cells.
Identification of the vasodilatory endothelial cannabinoid receptor in the human pulmonary artery.
Identification of three pertussis toxin substrates (41, 40 and 39 kDa proteins) in mammalian brain. Comparison of predicted amino acid sequences from G-protein alpha-subunit genes and cDNAs with partial amino acid sequences from purified proteins.
Identification of three separate guanine nucleotide-binding proteins that interact with the delta-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells.
Identification of two isoforms of mouse neuropeptide Y-Y1 receptor generated by alternative splicing. Isolation, genomic structure, and functional expression of the receptors.
Identification of two novel GTP-binding protein alpha-subunits that lack apparent ADP-ribosylation sites for pertussis toxin.
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.
Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.
Identifying long-term memory B-cells in vaccinated children despite waning antibody levels specific for Bordetella pertussis proteins.
Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis.
Identifying the G protein, Gz alpha, and its associated proteins in nervous tissue using mass spectrometry and microsequencing techniques.
Identity of adenylyl cyclase isoform determines the G protein mediating chronic opioid-induced adenylyl cyclase supersensitivity.
Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21.
IFN-gamma up-regulates the human C5a receptor (CD88) in myeloblastic U937 cells and related cell lines.
IFN-gamma-induced chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system.
IFN-gamma-mediated protection against intracerebral challenge with Bordetella pertussis in mice.
IFNgamma induces functional chemokine receptor expression in human mesangial cells.
IgE-Independent Activation of Human Mast Cells Indicates their Role in the Late Phase Reaction of Allergic Inflammation.
IGF-I and insulin induce different intracellular calcium signals in skeletal muscle cells.
IgG responses after booster vaccination with different pertussis vaccines in Dutch children 4 years of age: Effect of vaccine antigen content.
iGIST-A Kinetic Bioassay for Pertussis Toxin Based on Its Effect on Inhibitory GPCR Signaling.
IL-1 beta alters beta-adrenergic receptor adenylyl cyclase system function in human airway epithelial cells.
IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF+ Th17 cells.
IL-1 stimulates a diverging signaling pathway in EL4 6.1 thymoma cells. IL-2 release, but not IL-2 receptor expression, is sensitive to pertussis toxin.
IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation.
IL-10 enhances CCL2 release and chemotaxis induced by CCL16 in human monocytes.
IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice.
IL-15 induces mast cell migration via a pertussis toxin-sensitive receptor.
IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling.
IL-1beta activates p44/42 and p38 mitogen-activated protein kinases via different pathways in cat esophageal smooth muscle cells.
IL-1R signaling is required to overcome the effects of pertussis toxin and for efficient infection or vaccination induced immunity against Bordetella pertussis.
IL-2 secretion is pertussis toxin sensitive in a T lymphocyte hybridoma.
IL-3 Primes and Evokes Histamine Release from Human Basophils but not Mast Cells.
IL-3 stimulated haemopoietic stem cell proliferation: evidence for G protein independent mitogenic signalling events.
IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids.
IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways.
IL-8 induces a transient arrest of rolling eosinophils on human endothelial cells.
IL-8 induces the locomotion of human IL-2-activated natural killer cells. Involvement of a guanine nucleotide binding (Go) protein.
IL-8 production by human polymorphonuclear leukocytes. The chemoattractant formyl-methionyl-leucyl-phenylalanine induces the gene expression and release of IL-8 through a pertussis toxin-sensitive pathway.
IL1 induces proliferation and IL6 mRNA expression in a human astrocytoma cell line: positive and negative modulation by chorela toxin and cAMP.
Imipramine's selective suppression of an L-type calcium channel in neurons of murine dorsal root ganglia involves G proteins.
Immediate and neurotoxic effects of HIV protein gp120 act through CXCR4 receptor.
Immobilization Stress With ?2-Adrenergic Stimulation Induces Regional and Transient Reduction of Cardiac Contraction Through Gi Coupling in Rats.
Immortalized schwann cells express endothelin receptors coupled to adenylyl cyclase and phospholipase C.
Immune effector cells induced by complete Freund's adjuvant exert an inhibitory effect on antigen-specific type 2 T helper responses.
Immune response to a Tdap booster in vertically HIV-infected adolescents.
Immune response to dimeric subunits of the pertussis toxin B oligomer.
Immune response to the B oligomer of pertussis toxin.
Immune responses and antibody decay after immunization of adolescents and adults with an acellular pertussis vaccine: the APERT Study.
Immune responses to Bordetella pertussis infection and vaccination.
Immune suppression and induction of gamma interferon by pertussis toxin.
Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015.
Immunity to pertussis 5 years after booster immunization during adolescence.
Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019.
Immunization of Teenagers with a Fifth Dose of Reduced DTaP-IPV Induces High Levels of Pertussis Antibodies with a Significant Increase in Opsonophagocytic Activity.
Immuno-affinity purification and characterization of the alpha subunits of G0 type G proteins from various bovine tissues.
Immunochemical and electrophoretic characterization of the major pertussis toxin substrate of the RAW264 macrophage cell line.
Immunochemical comparison of pertussis toxin substrates in brain and peripheral tissues.
Immunochemical detection of GTP-binding protein in cephalopod photoreceptors by anti-peptide antibodies.
Immunochemical detection of guanine nucleotide binding proteins mono-ADP-ribosylated by bacterial toxins.
Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils.
Immunocytochemical and biochemical characterization of guanine nucleotide-binding regulatory proteins in mammalian spermatozoa.
Immunocytochemical localization of the guanine nucleotide-binding protein Go in primary cultures of neuronal and glial cells.
Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate.
Immunoelectron microscopy of antigens of Bordetella pertussis using monoclonal antibodies to agglutinogens 2 and 3, filamentous haemagglutinin, pertussis toxin, pertactin and adenylate cyclase toxin.
Immunogenicity after one, two or three doses and impact on the antibody response to coadministered antigens of a nonavalent pneumococcal conjugate vaccine in infants of Soweto, South Africa.
Immunogenicity and protective efficacy of a newly developed tri-component diphtheria, tetanus, and acellular pertussis vaccine in a murine model.
Immunogenicity and protective efficacy of neonatal vaccination against Bordetella pertussis in a murine model: evidence for early control of pertussis.
Immunogenicity and protective efficacy of pertussis toxin subunit S1 produced by Bacillus subtilis.
Immunogenicity and reactogenicity of a combined adsorbed tetanus toxoid, low dose diphtheria toxoid, five component acellular pertussis and inactivated polio vaccine in six-year-old children.
Immunogenicity and reactogenicity of a reduced-antigen-content diphtheria-tetanus-acellular pertussis vaccine as a single-dose booster in Singaporean adults.
Immunogenicity and reactogenicity of a single dose of a diphtheria--tetanus--acellular pertussis component vaccine (DTaP) compared to a diphtheria--tetanus toxoid (Td) and a diphtheria toxoid vaccine (d) in adults.
Immunogenicity and reactogenicity of diphtheria, tetanus and pertussis toxoids combined with inactivated polio vaccine, when administered concomitantly with or as a diluent for a Hib conjugate vaccine.
Immunogenicity and reactogenicity of the component acellular pertussis vaccine produced by a combination of column purified pertussis toxin and filamentous haemagglutinin.
Immunogenicity and safety after booster vaccination of diphtheria, tetanus, and acellular pertussis in young adults: an open randomized controlled trial in Japan.
Immunogenicity and safety of a monovalent, multicomponent acellular pertussis vaccine in 15 month-6-year-old German children. Monovalent Acellular Pertussis Vaccine Study Group.
Immunogenicity and safety of a pertussis vaccine composed of pertussis toxin inactivated by hydrogen peroxide, in 18- to 23-month-old children.
Immunogenicity and safety of a tetravalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine.
Immunogenicity and Safety of Monovalent Acellular Pertussis Vaccine at Birth: A Randomized Clinical Trial.
Immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type B conjugate vaccine (PRP-T) for primary and booster vaccinations.
Immunogenicity of a hexavalent combination vaccine in rhesus monkeys.
Immunogenicity of a three-component acellular pertussis vaccine administered at birth.
Immunogenicity of an acellular pertussis vaccine composed of genetically inactivated pertussis toxin combined with filamentous hemagglutinin and pertactin in infants and children.
Immunogenicity of combined diphtheria, tetanus, and pertussis vaccine given at 2, 3, and 4 months versus 3, 5, and 9 months of age.
Immunogenicity of glutaraldehyde inactivated pertussis vaccine.
Immunogenicity of primary DPT vaccination.
Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life.
Immunoglobulin A antibodies to pertussis toxin and filamentous hemagglutinin in saliva from patients with pertussis.
Immunoglobulin A with protease activity secreted in human milk activates PAR-2 receptors, of intestinal epithelial cells HT-29, and promotes beta-defensin-2 expression.
Immunoglobulin E and G responses to pertussis toxin after booster immunization in relation to atopy, local reactions and aluminium content of the vaccines.
Immunoglobulin E and G responses to pertussis toxin in children immunised with adsorbed and non-adsorbed whole cell pertussis vaccines.
Immunoglobulin E response to pertussis toxin in whooping cough and after immunization with a whole-cell and an acellular pertussis vaccine.
Immunohistochemical studies on melanin associated antigen (MAA) induced experimental autoimmune anterior uveitis (EAAU).
Immunologic and epidemiologic experience of vaccination with a monocomponent pertussis toxoid vaccine.
Immunological and biochemical differentiation of guanyl nucleotide binding proteins: interaction of Go alpha with rhodopsin, anti-Go alpha polyclonal antibodies, and a monoclonal antibody against transducin alpha subunit and Gi alpha.
Immunological and molecular characterization of Go alpha-like proteins in the Drosophila central nervous system.
Immunological characterization of guanine nucleotide-binding proteins: effects of a monoclonal antibody against the gamma subunit of transducin on guanine nucleotide-binding protein-receptor interactions.
Immunological localization of the GTP-binding protein Go in different tissues of vertebrates and invertebrates.
Immunological persistence in 5 y olds previously vaccinated with hexavalent DTPa-HBV-IPV/Hib at 3, 5, and 11 months of age.
Immunomagnetic separation and solid-phase detection of Bordetella pertussis.
Immunomodulation By Subchronic Low Dose 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin.
Immunomodulation of murine experimental autoimmune encephalomyelitis by pertussis toxin: the protective activity, but not the disease-enhancing activity, can be attributed to the nontoxic B-oligomer.
Immunomodulatory effects of recombinant BCG expressing pertussis toxin on TNF-alpha and IL-10 in a bladder cancer model.
Immunoprecipitation of a pertussis toxin substrate of the G(o) family from rat islets of Langerhans.
Impact of a pertussis booster vaccination program in adolescents and adults on the epidemiology of pertussis in Austria.
Impact of hypercholesterolemia on acidosis-induced coronary microvascular dilation.
Impact of infant and preschool pertussis vaccinations on memory B-cell responses in children at 4 years of age.
Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting.
Impact of pertussis-specific IgA, IgM, and IgG antibodies in mother's own breast milk and donor breast milk during preterm infant digestion.
Impaired 3',5'-cyclic adenosine monophosphate-mediated signaling in immediate early responsive gene X-1-deficient vascular smooth muscle cells.
Impaired cardiac muscarinic receptor function in dogs with heart failure.
Impaired formation of the second messenger cAMP in mononuclear blood cells of children with pertussis.
Impaired G protein function in gallbladder muscle from progesterone-treated guinea pigs.
Impaired G-proteins and cyclic nucleotide phosphodiesterase activity in T-lymphocytes from patients with sarcoidosis.
Impaired inhibitory G-protein function contributes to increased calcium currents in rats with diabetic neuropathy.
Impaired long-term maintenance and function of Bordetella pertussis specific B cell memory.
Impaired substance P release from renal sensory nerves in SHR involves a pertussis toxin-sensitive mechanism.
Impairment of beta-adrenergic signaling in healthy peripheral blood mononuclear cells exposed to serum from patients with septic shock: involvement of the inhibitory pathway of adenylyl cyclase stimulation.
Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production.
Implication of matrix metalloproteinases 2 and 9 in ceramide 1-phosphate-stimulated macrophage migration.
Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome.
Importance of ADP-ribosylation in the morphological changes of PC12 cells induced by cholera toxin.
Importance of CCL2-CCR2A/2B signaling for monocyte migration into spheroids of breast cancer-derived fibroblasts.
Importance of holotoxin assembly in Ptl-mediated secretion of pertussis toxin from Bordetella pertussis.
Improved pertussis toxin production by Bordetella pertussis through adjusting the growth medium's ionic composition.
Improved protocols for histamine sensitization testing of acellular pertussis vaccines.
Improved purification of transducin subunits from bovine retinal rod outer segments.
In human macrophages the complement component C5a induces the expression of oncostatin M via AP-1 activation.
In the developing hippocampus kainate receptors control the release of GABA from mossy fiber terminals via a metabotropic type of action.
In the developing rat hippocampus, endogenous activation of presynaptic kainate receptors reduces GABA release from mossy fiber terminals.
In vitro activation of murine DRG neurons by CGRP-mediated mucosal mast cell degranulation.
In vitro activation of murine peritoneal macrophages by monocyte chemoattractant protein-1: upregulation of CD11b, production of proinflammatory cytokines, and the signal transduction pathway.
In vitro activation of murine peritoneal macrophages by ultraviolet B radiation: upregulation of CD18, production of NO, proinflammatory cytokines and a signal transduction pathway.
In vitro and in vivo induction of nitric oxide by murine macrophages stimulated with Bordetella pertussis.
In vitro complement activation favoring soluble C5b-9 complex formation alters myocellular sodium homeostasis.
In vitro effect of chlorpyrifos oxon on muscarinic receptors and adenylate cyclase.
In vitro effects of 17 beta-oestradiol on the sensitivity of receptors coupled to adenylate cyclase on striatal neurons in primary culture.
In vitro Evidence of Human Immune Responsiveness Shows the Improved Potential of a Recombinant BCG Strain for Bladder Cancer Treatment.
In vitro formation and expansion of cysts derived from human renal cortex epithelial cells.
In vitro hypoxia impairs beta2-adrenergic receptor signaling in primary rat alveolar epithelial cells.
In vitro induction of antigen specific antibody synthesis and proliferation of T lymphocytes with acellular pertussis vaccines, pertussis toxin and filamentous haemagglutinin in humans.
In vitro model of angiogenesis using a human endothelium-derived permanent cell line: contributions of induced gene expression, G-proteins, and integrins.
In vitro modulation of growth hormone (GH) secretion from early to midgestation human fetal pituitaries by GH-releasing factor and somatostatin: role of Gs-adenylate cyclase-Gi complex and Ca2+ channels.
In vitro studies on responses to pentoxifylline and aminophylline of rat mesenteric resistance vessels.
In vivo anti-LAP mAb enhances IL-17/IFN-? responses and abrogates anti-CD3-induced oral tolerance.
In Vivo Dissection of Two Intracellular Pathways Involved in the Spinal Oxytocin-Induced Antinociception in the Rat.
In vivo evidence that lithium inactivates Gi modulation of adenylate cyclase in brain.
In vivo IL-1beta-induced modulation of G-protein alphaO subunit subclass in the hypothalamic ventromedial nucleus: implications to IL-1beta-associated anorexia.
In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity.
In Vivo Neutralization of Pertussis Toxin with Pertussis Antitoxin.
In vivo pertussis toxin administration: effects on the function and levels of Gi alpha proteins and their messenger ribonucleic acids.
In vivo pertussis toxin treatment attenuates some, but not all, adenosine A1 effects in slices of the rat hippocampus.
In vivo pertussis toxin treatment reduces contraction of rat resistance arteries but not that of mouse trachea.
In vivo pharmacology of butylthio[2.2.2] (LY297802 / NNC11-1053), an orally acting antinociceptive muscarinic agonist.
In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins.
Inactivation of (Gialpha) proteins increases arrhythmogenic effects of beta-adrenergic stimulation in the heart.
Inactivation of enhanced expression of G(i) proteins by pertussis toxin attenuates the development of high blood pressure in spontaneously hypertensive rats.
Inactivation of G(i) proteins by pertussis toxin diminishes the effectiveness of adrenergic stimuli in conduit arteries from spontaneously hypertensive rats.
Inactivation of Gi and G(o) proteins in nucleus accumbens reduces both cocaine and heroin reinforcement.
Inactivation of Gi proteins induces an antidepressant-like effect in the mouse forced-swimming test.
Inactivation of pertussis toxin-sensitive guanyl nucleotide-binding proteins increase parathyroid hormone receptors and reverse agonist-induced receptor down-regulation in ROS 17/2.8 cells.
Inactivation of raf-1 by a protein-tyrosine phosphatase stimulated by GTP and reconstituted by Galphai/o subunits.
Incidence and reproduction numbers of pertussis: estimates from serological and social contact data in five European countries.
Incidence of pertussis in persons < or =15 years of age in Valencia, Spain: seroprevalence of antibodies to pertussis toxin (PT) in children, adolescents and adults.
Incidence of pertussis infection in healthcare workers.
Incidence of seropositivity to bordetella pertussis and mycoplasma pneumoniae infection in patients with chronic laryngotracheitis.
Incomplete functional differentiation of HL-60 leukemic cells by synthetic lipopeptides. Partial inhibition by pertussis toxin of enhanced superoxide formation.
Increase in cytosolic free Ca2+ in corticotropin-stimulated white adipocytes.
Increase in functional activity rather than in amount of Gi-alpha in failing human heart with dilated cardiomyopathy.
Increase in Gs and cyclic AMP generation in HIT cells. Evidence that the 45-kDa alpha-subunit of Gs has greater functional activity than the 52-kDa alpha-subunit.
Increase in intradermal vascular permeability caused by pertussis toxin from Bordetella pertussis.
Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice.
Increase in [Ca2+]i by CCh in adult rat sympathetic neurons are not dependent on intracellular Ca2+ pools.
Increase of Gi alpha in human hearts with dilated but not ischemic cardiomyopathy.
Increase of myocardial inhibitory G-proteins in catecholamine-refractory septic shock or in septic multiorgan failure.
Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.
Increase of [Ca(2+)]i and release of arachidonic acid via activation of M2 receptor coupled to Gi and rho proteins in oesophageal muscle.
Increased Agonist Affinity at the ?-Opioid Receptor Induced by Prolonged Agonist Exposure.
Increased cAMP Signaling Can Ameliorate the Hypertensive Condition in Spontaneously Hypertensive Rats.
Increased cytosolic Ca2+ inhibits AVP-stimulated adenylyl cyclase activity in rat IMCT cells by activation of PKC.
Increased incorporation of arachidonic acid into phospholipids in zymosan-stimulated mouse peritoneal macrophages.
Increased intracellular cyclic adenosine monophosphate inhibits T lymphocyte-mediated cytolysis by two distinct mechanisms.
Increased levels of active pertussis toxin may aid a pertussis vaccine to pass the mouse body weight gain test.
Increased nociceptive input rapidly modulates spinal GABAergic transmission through endogenously released glutamate.
Increased plasma corticosterone, aggressiveness and brain monoamine changes induced by central injection of pertussis toxin.
Increased population prevalence of low pertussis toxin antibody levels in young children preceding a record pertussis epidemic in Australia.
Increased production of nitric oxide in coronary arteries during congestive heart failure.
Increased sensitivity of fat cell adenylate cyclase to stimulatory agonists during fasting is not related to impaired inhibitory coupling system.
Increased sensitivity of neonate atrial myocytes to adenosine A1 receptor stimulation in regulation of the L-type Ca2+ current.
Incubation of bovine thyroid slices with thyrotropin is associated with a decrease in the ability of pertussis toxin to adenosine diphosphate-ribosylate guanine nucleotide regulatory component(s).
Independence of, and interactions between, cannabinoid and opioid signal transduction pathways in N18TG2 cells.
Independent activation of endogenous p21-activated protein kinase-3 (PAK3) and JNK by thrombin in CCL39 fibroblasts.
Independent coupling of the human tachykinin NK2 receptor to phospholipases C and A2 in transfected Chinese hamster ovary cells.
Indications from Mn-quenching of Fura-2 fluorescence in melanotrophs that dopamine and baclofen close Ca channels that are spontaneously open but not those opened by high [K+]O; and that Cd preferentially blocks the latter.
Indirect inhibition by bradykinin of cyclic AMP generation in isolated rat glomeruli and mesangial cells.
Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils.
Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine.
Induction by chemokines of lipid mediator synthesis in granulocyte-macrophage colony-stimulating factor-treated human neutrophils.
Induction of a novel morphological response in Chinese hamster ovary cells by pertussis toxin.
Induction of a specific antibody response to Bordetella pertussis antigens in cultures of human peripheral blood mononuclear cells.
Induction of actin polymerization in permeabilized neutrophils. Role of ATP.
Induction of adenosine A1 receptor expression by pertussis toxin via an adenosine 5'-diphosphate ribosylation-independent pathway.
Induction of adherent activity in mastocytoma P-815 cells by the cooperation of two prostaglandin E2 receptor subtypes, EP3 and EP4.
Induction of antigen-specific T cell responses in human volunteers after intranasal immunization with a whole-cell pertussis vaccine.
Induction of Autoimmunity by Expansion of Autoreactive CD4+CD62Llow Cells In Vivo.
Induction of c-fos proto-oncogene by a chemotactic peptide in human peripheral granulocytes.
Induction of c-jun independent of PKC, pertussis toxin-sensitive G protein, and polyamines in quiescent SV40-transformed 3T3 T cells.
Induction of CD4(+) and CD8(+) Bordetella pertussis toxin subunit S1 specific T cells by immunization with synthetic peptides.
Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling.
Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.
Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination.
Induction of eosinophil cytokine generation by chemoattractants.
Induction of Experimental Allergic Encephalomyelitis in C57/BL6 Mice: An Animal Model for Multiple Sclerosis, Hossein Mostafavi, and Bahman Zeynali.
Induction of experimental autoimmune neuritis in CD4-8-C57BL/6J mice.
Induction of helper T cells by pertussis toxin during in vivo priming to insulin.
Induction of human neutrophil chemotaxis by Candida albicans-derived beta-1,6-long glycoside side-chain-branched beta-glucan.
Induction of humoral immunity in response to immunization with recombinant Mycobacterium bovis BCG expressing the S1 subunit of Bordetella pertussis toxin.
Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors.
Induction of macrophage apoptosis by Bordetella pertussis adenylate cyclase-hemolysin.
Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2.
Induction of microvascular leakage and histamine release by promutoxin, an Arg49 phospholipase A2.
Induction of muscarinic cholinergic responsiveness in Xenopus oocytes by mRNA isolated from rat brain.
Induction of natural killer cell migration by monocyte chemotactic protein-1, -2 and -3.
Induction of nitric oxide synthase mRNA by shear stress requires intracellular calcium and G-protein signals and is modulated by PI 3 kinase.
Induction of polyclonal antibodies to the S1 subunit of pertussis toxin by synthetic peptides coupled to PPD: effect of conjugation method, adjuvant, priming and animal species.
Induction of polyclonal CD8+ T cell activation and effector function by Pertussis toxin.
Induction of promiscuous G protein coupling of the follicle-stimulating hormone (FSH) receptor: a novel mechanism for transducing pleiotropic actions of FSH isoforms.
Induction of signal transduction in human neutrophils by Candida albicans hyphae: the role of pertussis toxin-sensitive guanosine triphosphate-binding proteins.
Induction of the fibrinogen receptor on human platelets by intracellular mediators.
Induction of tryptase and histamine release from human colon mast cells by IgE dependent or independent mechanisms.
Induction of type 1 immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12.
Infection of L6E9 myoblasts with Trypanosoma cruzi alters adenylate cyclase activity and guanine nucleotide binding proteins.
Infection of newborn piglets with Bordetella pertussis: a new model for pertussis.
Infiltration of tumors by systemically transferred tumor-reactive T lymphocytes is required for antitumor efficacy.
Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.
Inflammation- and ischemia-induced shedding of venular glycocalyx.
Inflammatory activation of neutrophils by Helicobacter pylori; a mechanism insensitive to pertussis toxin.
Inflammatory and contractile agents sensitize specific adenylyl cyclase isoforms in human airway smooth muscle.
Inflammatory effects of resistin on human smooth muscle cells: up-regulation of fractalkine and its receptor, CX3CR1 expression by TLR4 and Gi-protein pathways.
Inflammatory Responses Induced by Lipopolysaccharide Are Amplified in Primary Human Monocytes but Suppressed in Macrophages by Complement Protein C5a.
Influence of aluminum on the regulation of PTH- and 1,25(OH)2D3-dependent pathways in the rat osteosarcoma cell line ROS 17/2.8.
Influence of anti-beta-receptor antibodies on cardiac adenylate cyclase in patients with idiopathic dilated cardiomyopathy.
Influence of bacterial toxins and forskolin upon vasopressin-induced inositol phosphate accumulation in WRK 1 cells.
Influence of C-peptide on early glomerular changes in diabetic mice.
Influence of CR3 (CD11b/CD18) expression on phagocytosis of Bordetella pertussis by human neutrophils.
Influence of dietary omega-3 fatty acids on transmembrane signalling in rat submandibular salivary gland.
Influence of flupirtine on a G-protein coupled inwardly rectifying potassium current in hippocampal neurones.
Influence of G protein type on agonist efficacy.
Influence of Hesperidin on the Systemic and Intestinal Rat Immune Response.
Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression.
Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium.
Influence of pertussis toxin on CD1a isoform expression in human dendritic cells.
Influence of pertussis toxin on parathyroid hormone stimulated cyclic AMP production and phosphate transport in opossum kidney cells.
Influence of pertussis toxin on superficial bladder carcinoma in rats.
Influence of pertussis toxin on the calcitonin-opioid interaction in isolated tissues.
Influence of pertussis toxin on the effects of guanine nucleotide on adenylate cyclase in rat striatal membranes.
Influence of pertussis toxin on thermic responses to morphine and neurotensin in rats.
Influence of pertussis toxin pretreatment on the development of L-NAME-induced hypertension.
Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity.
Influence of the Adjuvants and Genetic Background on the Asthma Model Using Recombinant Der f 2 in Mice.
Influences of pertussis toxin, guanine nucleotides and forskolin on adenylate cyclase in striatal membranes of infant, adult and senescent rats.
Inhaled Bordetella pertussis vaccine decreases airway responsiveness in guinea pigs.
Inhibition and activation of interleukin 2 synthesis by direct modification of guanosine triphosphate-binding proteins.
Inhibition and superactivation of the calcium-stimulated isoforms of adenylyl cyclase: role of Gbetagamma dimers.
Inhibition by 5-hydroxytryptamine of the beta adrenoceptor-mediated positive inotropic responses to catecholamines in rabbit papillary muscles: direct interaction with beta adrenoceptors.
Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes.
Inhibition by brimonidine of forskolin-induced nitrite production in isolated pig ciliary processes.
Inhibition by CTLA4Ig of experimental allergic encephalomyelitis.
Inhibition by fluoxetine of voltage-activated ion channels in rat PC12 cells.
Inhibition by galanin and by high K+ of human basophil histamine release triggered by calcium ionophores but not responses induced by anti-IgE, chemotactic peptide or phorbol ester.
Inhibition by glucagon of the cGMP-inhibited low-Km cAMP phosphodiesterase in heart is mediated by a pertussis toxin-sensitive G-protein.
Inhibition by islet-activating protein of a chemotactic peptide-induced early breakdown of inositol phospholipids and Ca2+ mobilization in guinea pig neutrophils.
Inhibition by islet-activating protein, pertussis toxin, of P2-purinergic receptor-mediated iodide efflux and phosphoinositide turnover in FRTL-5 cells.
Inhibition by islet-activating protein, pertussis toxin, of retinoic acid-induced differentiation of human leukemic (HL-60) cells.
Inhibition by pertussis toxin of fibroblast growth factor-stimulated hexose transport in Swiss 3T3 cells.
Inhibition by pertussis toxin of guanyl nucleotides exchange on transducin in bovine rod cell membranes.
Inhibition by pertussis toxin of the activation of Na(+)-dependent uridine transport in dimethyl-sulphoxide-induced HL-60 leukaemia cells.
Inhibition by pertussis toxin of the soporific effects induced by stimulation of dopamine D2 autoreceptors in the ventral tegmental area in rats.
Inhibition by PGE2 of glucagon-induced increase in phosphoenolpyruvate carboxykinase mRNA and acceleration of mRNA degradation in cultured rat hepatocytes.
Inhibition by somatostatin of amylase secretion induced by calcium and cyclic AMP in rat pancreatic acini.
Inhibition by SR 59119A of isoprenaline-, forskolin- and VIP-induced relaxation of human isolated bronchi.
Inhibition by Wnt-1 or Wnt-3a of nerve growth factor-induced differentiation of PC12 cells is reversed by bisindolylmaleimide-I but not by several other PKC inhibitors.
Inhibition of a TREK-like K+ channel current by noradrenaline requires both ?1- and ?2-adrenoceptors in rat atrial myocytes.
Inhibition of acetylcholine release from guinea pig myenteric neurons by neuropeptide Y: GTP-binding protein mediation.
Inhibition of acid secretion by bombesin is partly mediated by release of fundic somatostatin.
Inhibition of ACTH secretion in mouse pituitary tumor cells by activation of muscarinic cholinergic receptors.
Inhibition of adenylate cyclase activity in the goldfish melanophore is mediated by alpha2-adrenoceptors and a pertussis toxin-sensitive GTP-binding protein.
Inhibition of adenylate cyclase from luteinized rat ovary by monovalent cations: roles of the stimulatory guanine nucleotide-binding regulatory component and stimulatory hormone receptor.
Inhibition of adenylate cyclase in bovine ciliary process and rabbit iris ciliary body to alpha 2-adrenergic agonists.
Inhibition of adenylyl cyclase activity by a homogeneous population of dopamine receptors: selective blockade by antisera directed against Gi1 and/or Gi2.
Inhibition of adenylyl cyclase activity in brain membrane fractions by arachidonic acid and related unsaturated fatty acids.
Inhibition of adenylyl cyclase by alpha chemokines IL-8 and GRO-alpha in Chinese hamster ovary cells expressing R1 and R2 receptors.
Inhibition of adenylyl cyclase by neuronal P2Y receptors.
Inhibition of adenylyl cyclases by 12(S)-hydroxyeicosatetraenoic acid.
Inhibition of alpha(1)-adrenergic-mediated responses in rat ventricular myocytes by adenosine A(1) receptor activation: role of the K(ATP) channel.
Inhibition of AMPA receptor-stimulated 57Co2+ influx by D- and L-2-amino-4-phosphonobutanoic acid (D- and L-AP4) and L-serine-O-phosphate (L-SOP) in cultured cerebellar granule cells.
Inhibition of angiotensin II-stimulated inositol phosphate production by D2-dopamine receptor is calcium-dependent in human trophoblastic cells.
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.
Inhibition of ATP-induced cAMP formation by 5'-p-fluorosulfonylbenzoyladenosine in NG108-15 cells.
Inhibition of basal and corticotropin-releasing hormone-stimulated adenylate cyclase activity and cytosolic Ca2+ levels by somatostatin in human corticotropin-secreting pituitary adenomas.
Inhibition of bombesin-induced mitogenesis by pertussis toxin: dissociation from phospholipase C pathway.
Inhibition of bovine rod outer segment GTPase by Bordetella pertussis toxin.
Inhibition of Ca(2+) entry caused by depolarization in acetylcholine-stimulated antral mucous cells of guinea pig: G protein regulation of Ca(2+) permeable channels.
Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1).
Inhibition of Ca(2+)-induced calcitonin secretion by somatostatin: roles of voltage dependent Ca2+ channels and G-proteins.
Inhibition of Ca2+ channels via alpha 2-adrenergic and muscarinic receptors in pheochromocytoma (PC-12) cells.
Inhibition of calcium currents by noradrenaline, somatostatin and opioids in guinea-pig submucosal neurones.
Inhibition of calcium currents in cultured myenteric neurons by neuropeptide Y: evidence for direct receptor/channel coupling.
Inhibition of calcium currents in rat colon sensory neurons by K- but not mu- or delta-opioids.
Inhibition of calcium spikes by gamma-amino-butyric acid in the neurons of Lymnaea stagnalis L.
Inhibition of calcium transients in cultured vascular smooth muscle cells by pertussis toxin.
Inhibition of cAMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA.
Inhibition of cAMP production by alpha 2-adrenoceptor stimulation in rabbit retina.
Inhibition of chemokine (C-X-C motif) ligand 12/chemokine (C-X-C motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells.
Inhibition of cholinergic transmission by opiates in ileal myenteric plexus is mediated by kappa receptor. Involvement of regulatory inhibitory G protein and calcium N-channels.
Inhibition of cyclic AMP accumulation by endothelin is pertussis toxin sensitive and calcium independent in isolated adult feline cardiac myocytes.
Inhibition of delayed rectifier K+ conductance in cultured rat cerebellar granule neurons by activation of calcium-permeable AMPA receptors.
Inhibition of dopamine release by prostaglandin EP3 receptor via pertussis toxin-sensitive and -insensitive pathways in PC12 cells.
Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways.
Inhibition of endothelin-mediated topoisomerase I activation by pertussis toxin.
Inhibition of endothelium-dependent relaxations by phorbol myristate acetate in canine coronary arteries: role of a pertussis toxin-sensitive G-protein.
Inhibition of epithelial Na+ transport by atriopeptin, protein kinase c, and pertussis toxin.
Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acids.
Inhibition of fetal rat pancreatic beta-cell replication by interleukin-1 beta in vitro is not mediated through pertussis toxin-sensitive G-proteins, a decrease in cyclic AMP, or protease activation.
Inhibition of formation of cyclic AMP and cyclic GMP by vasopressin in smooth-muscle cells is insensitive to pertussis toxin.
Inhibition of FSH-stimulated cAMP accumulation by mono(2-ethylhexyl) phthalate in primary rat Sertoli cell cultures.
Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling.
Inhibition of G protein in human sperm and its influence on acrosome reaction and zona pellucida binding.
Inhibition of G-protein betagamma-subunit functions by phosducin-like protein.
Inhibition of Gi proteins by low density lipoprotein attenuates bradykinin-stimulated release of endothelial-derived nitric oxide.
Inhibition of glucagon-signaling and downstream actions by interleukin 1beta and tumor necrosis factor alpha in cultured primary rat hepatocytes.
Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells.
Inhibition of glycogen synthesis by epidermal growth factor in hepatocytes. The role of cell density and pertussis toxin-sensitive GTP-binding proteins.
Inhibition of GTPase activity of Gi proteins and decreased agonist affinity at M2 muscarinic acetylcholine receptors by spermine and methoctramine.
Inhibition of hepatic adenylate cyclase by NADH.
Inhibition of hormonally induced inositol trisphosphate production in Transfected GH4C1 cells: A novel role for the D5 subtype of the dopamine receptor.
Inhibition of human thyroid adenylyl cyclase by 2-iodoaldehydes.
Inhibition of immunoglobulin E production by Poncirus trifoliata fruit extract.
Inhibition of inositol phosphate production is a late, Ca2+-dependent effect of D2 dopaminergic receptor activation in rat lactotroph cells.
Inhibition of insulin secretion from rat pancreatic islets by dexmedetomidine and medetomidine, two sedatives frequently used in clinical settings.
Inhibition of interleukin 3 and colony-stimulating factor 1-stimulated marrow cell proliferation by pertussis toxin.
Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function.
Inhibition of intra- and extra-cellular Tat function and HIV expression by pertussis toxin B-oligomer.
Inhibition of inward rectifier K+ currents by angiotensin II in rat atrial myocytes: lack of effects in cells from spontaneously hypertensive rats.
Inhibition of inwardly rectifying K+ current by external Ca2+ ions in freshly isolated rabbit osteoclasts.
Inhibition of isoproterenol-induced lipolysis in rat inguinal adipocytes in vitro by physiological melatonin via a receptor-mediated mechanism.
Inhibition of L-type Ca(2+) current by ginsenoside Rd in rat ventricular myocytes.
Inhibition of L-type calcium channels by internal GTP [gamma S] in mouse pancreatic beta cells.
Inhibition of L-type calcium currents in guinea pig ventricular myocytes by the kappa-opioid agonist U50488H does not involve binding to opiate receptors.
Inhibition of lipid phosphate phosphatase activity by VPC32183 suppresses the ability of diacylglycerol pyrophosphate to activate ERK(1/2) MAP kinases.
Inhibition of lipolysis by agents acting via adenylate cyclase in fat cells from infants and adults.
Inhibition of lymphocyte and neutrophil chemotaxis by pertussis toxin.
Inhibition of lymphocyte circulation in mice by pertussis toxin.
Inhibition of lymphoma invasion and liver metastasis formation by pertussis toxin.
Inhibition of M-type K+ and N-type Ca2+ channels by the human gonadotropin-releasing-hormone receptor heterologously expressed in adult neurons.
Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive G i -proteins in murine BV-2 microglia cells.
Inhibition of mink lung epithelial cell proliferation by transforming growth factor-beta is coupled through a pertussis-toxin-sensitive substrate.
Inhibition of monocyte oxidative responses by Bordetella pertussis adenylate cyclase toxin.
Inhibition of muscle cell relaxation by somatostatin: tissue-specific, cAMP-dependent, pertussis toxin-sensitive.
Inhibition of N- and P/Q-type calcium channels by postsynaptic GABAB receptor activation in rat supraoptic neurones.
Inhibition of N-type Ca2+ channel currents in human neuroblastoma (SH-SY5Y) cells by muscarine via stimulation of M3 receptors.
Inhibition of N-type calcium channels by activation of GPR35, an orphan receptor, heterologously expressed in rat sympathetic neurons.
Inhibition of NAD+ glycohydrolase and ADP-ribosyl cyclase activities of leukocyte cell surface antigen CD38 by gangliosides.
Inhibition of noradrenaline release by neuropeptide Y in mouse atria does not involve inhibition of adenylate cyclase or a pertussis toxin-susceptible G protein.
Inhibition of oxytocin-stimulated phosphoinositide turnover in rat myometrium by pertussis and cholera toxins may involve protein kinase A activation.
Inhibition of parathyroid hormone release by maitotoxin, a calcium channel activator.
Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor.
Inhibition of parietal cell H+ secretion by transforming growth factor alpha: a possible autocrine regulatory mechanism.
Inhibition of pertussis toxin binding to model receptors by antipeptide antibodies directed at an antigenic domain of the S2 subunit.
Inhibition of pertussis toxin catalyzed ADP-ribosylation of G-proteins by membrane depolarization in rat brain synaptoneurosomes.
Inhibition of platelet-activating factor-induced retinal impairments by cholera and pertussis toxins.
Inhibition of potassium and calcium currents in neurones by molecularly-defined P2Y receptors.
Inhibition of prolactin release by gonadotropin-releasing hormone-associated Peptide in benign, dopamine-sensitive and in malignant, dopamine-resistant pituitary tumors.
Inhibition of prolactin secretion by endothelin-3 is pertussis toxin-sensitive.
Inhibition of protein phosphatase 2A (PP2A) mimics suckling-induced sensitization of mammotropes: involvement of a pertussis toxin (PTX) sensitive G-protein and the adenylate cyclase (AC).
Inhibition of quantal transmitter release in the absence of calcium influx by a G protein-linked adenosine receptor at hippocampal synapses.
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin.
Inhibition of renal Na+-ATPase activity by inosine is mediated by A1 receptor-induced inhibition of the cAMP signaling pathway.
Inhibition of Rho-Kinase Abrogates Migration of Human Transitional Cell Carcinoma Cells: Results of an in vitro Study.
Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.
Inhibition of stimulated amylase secretion by adrenomedullin in rat pancreatic acini.
Inhibition of striatal GABA release by the adenosine A2a receptor is not mediated by increases in cyclic AMP.
Inhibition of swine microglial cell phagocytosis of Cryptococcus neoformans by femtomolar concentrations of morphine.
Inhibition of T cell homing by down-regulation of CD62L and the induction of a Th-2 response as a method to prevent acute allograft rejection in mice.
Inhibition of the cAMP signaling cascade via cannabinoid receptors: a putative mechanism of immune modulation by cannabinoid compounds.
Inhibition of the effects of adenosine on force of contraction and the slow calcium inward current by pertussis toxin is associated with myocardial lesions.
Inhibition of the GTPase activity of transducin by an NAD+:arginine ADP-ribosyltransferase from turkey erythrocytes.
Inhibition of the hyperpolarization-activated current (if) of rabbit SA node myocytes by niflumic acid.
Inhibition of the L-type calcium channel by the five muscarinic receptors (m1-m5) expressed in NIH 3T3 cells.
Inhibition of the magnesium-sensitive TRPM7-like channel in cardiac myocytes by nonhydrolysable GTP analogs: involvement of phosphoinositide metabolism.
Inhibition of the omega-conotoxin-sensitive calcium current by distinct G proteins.
Inhibition of the T-type Ca2+ current by the dopamine D1 receptor in rat adrenal glomerulosa cells: requirement of the combined action of the G betagamma protein subunit and cyclic adenosine 3',5'-monophosphate.
Inhibition of thyrotropin-stimulated adenosine 3',5'-monophosphate formation in rat thyroid cells by an adenosine analog. Evidence that the inhibition is mediated by the putative inhibitory guanine nucleotide regulatory protein.
Inhibition of transmitter release from rat sympathetic neurons via presynaptic M(1) muscarinic acetylcholine receptors.
Inhibition of tumor necrosis factor-induced p42/p44 mitogen-activated protein kinase activation by sodium salicylate.
Inhibition of tumour necrosis factor and reversal of endotoxin-induced shock by U-83836E, a 'second generation' lazaroid in rats.
Inhibition of vasopressin-stimulated cyclic AMP accumulation by alpha-2 adrenoceptor agonists in isolated papillary collecting ducts.
Inhibition of voltage-dependent Ca(2+)-current by alpha-adrenoceptor agonists in smooth muscle cells.
Inhibition of voltage-dependent Ca2+ channels via alpha 2-adrenergic and opioid receptors in cultured bovine adrenal chromaffin cells.
Inhibition of voltage-dependent Ca2+ currents and activation of pertussis toxin-sensitive G-proteins via muscarinic receptors in GH3 cells.
Inhibition of voltage-dependent calcium channels by prostaglandin E2 in rat melanotrophs.
Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states.
Inhibitors of diacylglycerol metabolism reduce time to the onset of glutamate release potentation by mGlu7 receptors.
Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release.
Inhibitory action of forskolin on adenylate cyclase activity and cyclic AMP generation.
Inhibitory action of pertussis toxin on parathyroid hormone and prostaglandin E2-stimulated bone resorption in cultured neonatal mouse calvaria.
Inhibitory action of somatostatin on cAMP dependent pepsinogen secretion from rat gastric chief cells: involvement of pertussis toxin-sensitive G-protein.
Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes.
Inhibitory actions of somatostatin on cyclic AMP and aldosterone production in agonist-stimulated adrenal glomerulosa cells.
Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform.
Inhibitory effect of ?-hydroxybutyric acid on L-type Ca(2+) current under ?-adrenergic stimulation in guinea pig cardiac ventricular myocytes.
Inhibitory effect of adenosine on electrical activity of frog melanotrophs mediated through A1 purinergic receptors.
Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced nonselective cation current in Guinea pig ventricular myocytes.
Inhibitory effect of hypochlorous acid on lower esophageal sphincter tone relaxation by vasoactive intestinal peptide.
Inhibitory effect of melatonin on gonadotropin-releasing hormone-induced Ca2+ oscillations in pituitary cells of newborn rats.
Inhibitory effect of muscarinic receptor activation on Ca2+ channel current in smooth muscle cells of guinea-pig ileum.
Inhibitory effect of neuropeptide Y and its analogues on inositol 1,4,5-trisphosphate level in rat cardiomyocytes.
Inhibitory effect of octopamine on the release of endogenous acetylcholine from isolated myenteric synaptosomes of guinea-pig.
Inhibitory effect of somatostatin on cAMP accumulation and calcitonin secretion in C-cells: involvement of pertussis toxin-sensitive G-proteins.
Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens.
Inhibitory effects of C4a on chemoattractant and secretagogue functions of the other anaphylatoxins via Gi protein-adenylyl cyclase inhibition pathway in mast cells.
Inhibitory effects of glibenclamide and pertussis toxin on the attenuation of ischemia-induced myocardial acidosis following ischemic preconditioning in dogs.
Inhibitory effects of opioids on voltage-dependent Ca(2+) channels and catecholamine secretion in cultured porcine adrenal chromaffin cells.
Inhibitory effects of pertussis toxin on a depolarization-evoked Ca2+ influx in NG108-15 cells.
Inhibitory effects of pertussis toxin on the cAMP generating system in human mononuclear leucocytes.
Inhibitory G protein-mediated modulation of slow delayed rectifier potassium channels contributes to increased susceptibility to arrhythmogenesis in aging heart.
Inhibitory glutamate response on cyclic AMP formation in cultured astrocytes.
Inhibitory GTP-binding regulatory protein Gi3 can couple angiotensin II receptors to inhibition of adenylyl cyclase in hepatocytes.
Inhibitory guanine nucleotide regulatory protein activation of mitogen-activated protein kinase in experimental hepatocellular carcinoma in vitro.
Inhibitory guanine-nucleotide-binding-regulatory protein alpha subunits in medaka (Oryzias latipes) oocytes--cDNA cloning and decreased expression of proteins during oocyte maturation.
Inhibitory guanosine triphosphate-binding protein-mediated regulation of vasopressin action in isolated single medullary tubules of mouse kidney.
Inhibitory interaction of cannabinoid CB1 receptor and dopamine D2 receptor agonists on voltage-gated currents of goldfish cones.
Inhibitory modulation of fast and slow Ca(2+)-currents in neuroblastoma x glioma cells during differentiation.
Inhibitory phosphorylation of soluble guanylyl cyclase by muscarinic m2 receptors via Gbetagamma-dependent activation of c-Src kinase.
Inhibitory prejunctional muscarinic receptors at sympathetic nerves do not operate through a cyclic AMP dependent pathway.
Inhibitory role of the somatostatin receptor SST2 on the intracrine-regulated cell proliferation induced by the 210-amino acid fibroblast growth factor-2 isoform: implication of JAK2.
Inhibitory signaling by CB1 receptors in smooth muscle mediated by GRK5/?-arrestin activation of ERK1/2 and Src kinase.
Initiation and regulation of CNS autoimmunity.
Initiation of immune responses in brain is promoted by local dendritic cells.
Initiation of RVD response in human platelets: mechanical-biochemical transduction involves pertussis-toxin-sensitive G protein and phospholipase A2.
Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-?B-sensitive pathways.
Inosine stimulates chemotaxis, Ca2+-transients and actin polymerization in immature human dendritic cells via a pertussis toxin-sensitive mechanism independent of adenosine receptors.
Inositol 1,4,5-triphosphate-induced granule secretion in platelets. Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein-dependent mechanism distinct from that of thrombin.
Inositol 1,4,5-trisphosphate formation and ryanodine-sensitive oscillations of cytosolic free Ca2+ concentrations in neuroblastoma x fibroblast hybrid NL308 cells expressing m2 and m4 muscarinic acetylcholine receptor subtypes.
Inositol 1,4,5-trisphosphate-independent Ca(2+) mobilization triggered by a lipid factor isolated from vitreous body.
Inositol 1-,4-,5-trisphosphate-dependent Ca2+ signaling by the recombinant human PTH/PTHrP receptor stably expressed in a human kidney cell line.
Inositol phosphate formation and chloride current responses induced by acetylcholine and serotonin through GTP-binding proteins in Xenopus oocyte after injection of rat brain messenger RNA.
Inositol phosphate metabolism in bradykinin-stimulated human A431 carcinoma cells. Relationship to calcium signalling.
Inositol phosphates modulate human red blood cell Ca(2+)-adenosine triphosphatase activity in vitro by a guanine nucleotide regulatory protein.
Inositol phospholipid turnover in PAF transmembrane signalling.
Inositol trisphosphate mediates cloned muscarinic receptor-activated conductances in transfected mouse fibroblast A9 L cells.
Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine m1-m4 receptors in neuroblastoma-derived hybrid cells.
Inositol-1,4,5-trisphosphate accumulation induced by urinary pheromones in female rat vomeronasal epithelium.
Inotropic changes induced by fluoroaluminates in rabbit left atrial muscles: possible involvement of G proteins.
Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin.
Insoluble immune complex-stimulated neutrophil leukotriene B4 production is dependent on Fc gamma RII and Fc gamma RIII and independent of pertussis toxin-sensitive signal transduction pathways.
Insulin activates G alpha il,2 protein in rat hepatoma (HTC) cell membranes.
Insulin activates glycerol-3-phosphate acyltransferase (de novo phosphatidic acid synthesis) through a phospholipid-derived mediator. Apparent involvement of Gi alpha and activation of a phospholipase C.
Insulin activates GTP binding to a 40 kDa protein in fat cells.
Insulin activation of cyclic AMP phosphodiesterase in intact ureteral segments.
Insulin affects the ability of Gi to be ADP-ribosylated but does not elicit its phosphorylation in intact hepatocytes.
Insulin enhances endothelial alpha2-adrenergic vasorelaxation by a pertussis toxin mechanism.
Insulin enhances vascular endothelial growth factor, interleukin-8, and plasminogen activator inhibitor 1 but not interleukin-6 release by human adipocytes.
Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins.
Insulin releasing effects of mastoparan and amphiphilic substance P receptor antagonists on RINm5F insulinoma cells.
Insulin secretion and action.
Insulin secretion is stimulated by ethanol extract of Anemarrhena asphodeloides in isolated islet of healthy Wistar and diabetic Goto-Kakizaki Rats.
Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on G?(i2).
Insulin sensitizes a cultured rat osteogenic sarcoma cell line to hormones which activate adenylate cyclase.
Insulin stimulates a novel GTPase activity in human platelets.
Insulin stimulates the release of a subset of GPI-anchored proteins in a G-protein independent manner.
Insulin stimulation of cyclic AMP phosphodiesterase is independent from the G-protein pathways involved in adenylate cyclase regulation.
Insulin stimulation of Na/H antiport in L-6 cells: a different mechanism in myoblasts and myotubes.
Insulin-dependent release of 5'-nucleotidase and alkaline phosphatase from liver plasma membranes.
Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2.
Insulin-induced expression of prostacyclin receptors on platelets is mediated through ADP-ribosylation of Gi alpha protein.
Insulin-like growth factor binding protein-3 stimulates phosphatidylinositol 3-kinase in MCF-7 breast carcinoma cells.
Insulin-like Growth Factor Binding Protein-5 Stimulates Growth of Human Intestinal Muscle Cells by Activation of G{alpha}i3.
Insulin-like growth factor binding proteins increase intracellular calcium levels in two different cell lines.
Insulin-like growth factor II inhibits glucose-induced insulin exocytosis.
Insulin-like growth factor II signaling through the insulin-like growth factor II/mannose-6-phosphate receptor promotes exocytosis in insulin-secreting cells.
Insulin-like growth factor II stimulates calcium influx in competent BALB/c 3T3 cells primed with epidermal growth factor. Characteristics of calcium influx and involvement of GTP-binding protein.
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes.
Insulin-like growth factor-I induces alpha(1B)-adrenergic receptor phosphorylation through G beta gamma and epidermal growth factor receptor transactivation.
Insulin-like growth factor-I potentiates thyrotropin stimulation of adenylyl cyclase in FRTL-5 cells.
Insulin-like growth factor-II/mannose 6-phosphate receptor is incapable of activating GTP-binding proteins in response to mannose 6-phosphate, but capable in response to insulin-like growth factor-II.
Insulin-like growth factors enhance phagocytosis by human neutrophils in vitro.
Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.
Insulin-like growth factors stimulate chemotaxis in human melanoma cells.
Insulin-stimulated NADH/NAD+ redox state increases NAD(P)H oxidase activity in cultured rat vascular smooth muscle cells.
Insulin-stimulated phosphatidylcholine hydrolysis, diacylglycerol/protein kinase C signalling, and hexose transport in pertussis toxin-treated BC3H-1 myocytes.
Insulinotropic toxins as molecular probes for analysis of glucagon-likepeptide-1 receptor-mediated signal transduction in pancreatic beta-cells.
Integration of G-protein coupled receptor signaling pathways for activation of a transcription factor (EGR-3).
Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase.
Integrin alpha v beta 3 and phospholipase C regulate prostacyclin formation of endothelial cells caused by ancrod-generated fibrin.
Integrin alphavbeta3 mediates chemotactic and haptotactic motility in human melanoma cells through different signaling pathways.
Integrin-associated protein stimulates alpha2beta1-dependent chemotaxis via Gi-mediated inhibition of adenylate cyclase and extracellular-regulated kinases.
Integrin-dependence of lymphocyte entry into the splenic white pulp.
Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway.
Integrin-mediated localization of Bordetella pertussis within macrophages: role in pulmonary colonization.
Interaction between calcium channel ligands and guanine nucleotides in cultured rat sensory and sympathetic neurones.
Interaction between mGluR8 and calcium channels in photoreceptors is sensitive to pertussis toxin and occurs via G protein betagamma subunit signaling.
Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice.
Interaction between Src homology 2 domain bearing protein tyrosine phosphatase substrate-1 and CD47 mediates the adhesion of human B lymphocytes to nonactivated endothelial cells.
Interaction between the RGS domain of RGS4 with G protein alpha subunits mediates the voltage-dependent relaxation of the G protein-gated potassium channel.
Interaction of adenosine with vasopressin in the inner medullary collecting duct.
Interaction of agonists and selective antagonists with gastric smooth muscle muscarinic receptors.
Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel.
Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells.
Interaction of Bordetella pertussis virulence components with neutrophils: effect on chemiluminescence induced by a chemotactic peptide and by intact bacteria.
Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin.
Interaction of D2-dopamine receptor with two pertussis toxin sensitive G proteins in human placenta.
Interaction of GTP-binding proteins with calmodulin.
Interaction of GTP-binding regulatory proteins with chemosensory receptors.
Interaction of guanine-nucleotide-binding regulatory proteins with chemotactic peptide receptors in differentiated human leukemic HL-60 cells.
Interaction of halothane with inhibitory G-proteins in the human myocardium.
Interaction of human Tamm-Horsfall glycoprotein with Bordetella pertussis toxin.
Interaction of monoclonal antibodies with pertussis toxin and its subunits.
Interaction of pertussis toxin with cells and model membranes.
Interaction of pertussis toxin with human T lymphocytes.
Interaction of purified bovine brain A1-adenosine receptors with guanine nucleotide-binding proteins of human platelet membranes following reconstitution.
Interaction of substance P, compound 48/80 and mastoparan with the alpha-subunit C-terminus of G protein.
Interaction of the alpha-2 adrenergic- and opioid receptor with the cGMP system in the mouse cerebellum.
Interaction of the frog brain kainate receptor expressed in Chinese hamster ovary cells with a GTP-binding protein.
Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions.
Interaction of the inhibitory GTP regulatory component with soluble cerebral cortical adenylate cyclase.
Interaction of the pertussis toxin peptide containing residues 30-42 with DR1 and the T-cell receptors of 12 human T-cell clones.
Interaction of vascular alpha-1 adrenoceptors with multiple signal transduction pathways.
Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling.
Interaction of [3H]spiperone with rat striatal dopamine D-2 receptors: kinetic evidence for antagonist-induced formation of ternary complex.
Interaction with caveolin-1 modulates G protein coupling of mouse ?3-adrenoceptor.
Interactions between a lymphoma membrane-associated guanosine 5'-triphosphate-binding protein and the cytoskeleton during receptor patching and capping.
Interactions between adenylate cyclase inhibitors and beta-adrenoceptors in isolated human fat cells.
Interactions between the amyloid precursor protein C-terminal domain and G proteins mediate calcium dysregulation and amyloid beta toxicity in Alzheimer's disease.
Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase.
Interactions of alpha-melanotropin and agouti on B16 melanoma cells: evidence for inverse agonism of agouti.
Interactions of bradykinin, calcium, G-protein and protein kinase in the activation of phospholipase A2 in bovine pulmonary artery endothelial cells.
Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue.
Interactions of intracerebroventricular pertussis toxin treatment with the ataxic and hypothermic effects of ethanol.
Interactions of lithium and drugs that affect signal transduction on behaviour in rats.
Interactions of multiple signaling pathways in neuropeptide Y-mediated bimodal vascular smooth muscle cell growth.
Interactions of phosducin with defined G protein beta gamma-subunits.
Interactions of the alpha2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants.
Interactive effects of pertussis toxin and the phorbol ester tumour promotor, phorbol dibutyrate, on T-lymphocyte mitogenesis and the expression of phenotypic determinants.
Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule.
Interchangeability of two diphtheria and tetanus toxoids, acellular pertussis, inactivated poliovirus, Haemophilus influenzae type b conjugate vaccines as a fourth dose in 15-20-month-old toddlers.
Interferon-gamma and lipopolysaccharide reduce cAMP responses in cultured glial cells: reversal by a type IV phosphodiesterase inhibitor.
Interferon-gamma elicits a G-protein-dependent Ca2+ signal in human neutrophils after depletion of intracellular Ca2+ stores.
Interferon-gamma levels in serum and bronchoalveolar lavage fluid of mice infected with Bordetella pertussis.
Interferon-gamma-stimulated and GTP-binding-proteins-mediated phospholipase A2 activation in human neuroblasts.
Interferon-inducible protein-10 and lymphotactin induce the chemotaxis and mobilization of intracellular calcium in natural killer cells through pertussis toxin-sensitive and -insensitive heterotrimeric G-proteins.
Interleukin (IL)-8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C.
Interleukin 1 and tumor necrosis factor stimulate human vascular endothelial cells to promote transendothelial neutrophil passage.
Interleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways.
Interleukin 1b and anaphylatoxins exert a synergistic effect on NGF expression by astrocytes.
Interleukin 3-stimulated proliferation is sensitive to pertussis toxin: evidence for a guanyl nucleotide regulatory protein-mediated signal transduction mechanism.
Interleukin-1 beta inhibition of insulin release in rat pancreatic islets: possible involvement of G-proteins in the signal transduction pathway.
Interleukin-1 beta inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C.
Interleukin-1 beta stimulation of 45Ca2+ release from rat striatal slices.
Interleukin-1 induces a pertussis toxin-sensitive increase in diacylglycerol accumulation in mouse thymoma cells.
Interleukin-1 inhibits voltage-dependent P/Q-type Ca2+ channel associated with the inhibition of the rise of intracellular free Ca2+ concentration and catecholamine release in adrenal chromaffin cells.
Interleukin-1 is a motility factor for human breast carcinoma cells in vitro: additive effect with interleukin-6.
Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4).
Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA.
Interleukin-1 stimulates the release of interleukin-6 from cultured human pituitary adenoma cells.
Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting induction of Th1 cells.
Interleukin-13 is a monocyte chemoattractant.
Interleukin-1beta-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine.
Interleukin-1beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP.
Interleukin-1beta-induced prostaglandin E2 production in human myometrial cells: role of a pertussis toxin-sensitive component.
Interleukin-36? is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis.
Interleukin-37 (IL-37) Suppresses Pertussis Toxin-Induced Inflammatory Myopathy in a Rat Model.
Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-gamma in primary pig adipocytes.
Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alpha.
Interleukin-6 synthesis induced by prostaglandin E2: cross-talk regulation by protein kinase C.
Interleukin-8 production induced by the endozepine triakontatetraneuropeptide in human neutrophils: role of calcium and pharmacological investigation of signal transduction pathways.
Interleukin-8 receptors R1 and R2 activate mitogen-activated protein kinases and induce c-fos, independent of Ras and Raf-1 in Chinese hamster ovary cells.
Interleukin-8 secreted by endothelial cells induces chemotaxis of melanoma cells through the chemokine receptor CXCR1.
Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation.
Interleukin-8: An autocrine inflammatory mediator.
Internalization and recycling of human mu opioid receptors expressed in Sf9 insect cells.
Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3.
Internalization of the radioiodinated somatostatin analog [125I-Tyr3]octreotide by mouse and human pituitary tumor cells: increase by unlabeled octreotide.
Internalization of [DOTA degrees,125I-Tyr3]Octreotide by somatostatin receptor-positive cells in vitro and in vivo: implications for somatostatin receptor-targeted radio-guided surgery.
Internalization pathway of C3b receptors in human neutrophils and its transmodulation by chemoattractant receptors stimulation.
International Bordetella pertussis assay standardization and harmonization meeting report. Centers for Disease Control and Prevention, Atlanta, Georgia, United States, 19-20 July 2007.
International Union of Pharmacology LVII: Recommendations for the Nomenclature of Receptors for Relaxin Family Peptides.
Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: role of interleukin 1beta.
Intra-accumbens pertussis toxin sensitizes rats to the locomotor activating effects of a single cocaine challenge.
Intracellular acidification, guanine-nucleotide binding proteins, and cytoskeletal actin.
Intracellular beta-blockade: overexpression of Galpha(i2) depresses the beta-adrenergic response in intact myocardium.
Intracellular Ca(2+) signaling in endothelial cells by the angiogenesis inhibitors endostatin and angiostatin.
Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional signalling in the stimulation by platelet-activating factor of prostaglandin E2 formation in P388D1 macrophage-like cells.
Intracellular calcium ion responses to somatostatin in cells from human somatotroph adenomas.
Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells.
Intracellular calcium mobilization in response to the activation of human wild-type and chimeric gonadotropin receptors.
Intracellular calcium mobilization triggered by a glutamate receptor in rat cultured hippocampal cells.
Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: role of protein kinase C.
Intracellular Cl- modulates Ca2+-induced exocytosis from rat melanotrophs through GTP-binding proteins.
Intracellular control of calcium and potassium currents in cardiac cells.
Intracellular coupling of prostaglandin inhibition of acid secretion in isolated rabbit gastric parietal cells.
Intracellular cross-talk between receptors coupled to phospholipase C via pertussis toxin sensitive and insensitive G-proteins.
Intracellular cross-talk between receptors coupled to phospholipase C via pertussis toxin-sensitive and insensitive G-proteins in DDT1MF-2 cells.
Intracellular cross-talk between thyrotropin receptor and A1 adenosine receptor in regulation of phospholipase C and adenylate cyclase in COS-7 cells transfected with their receptor genes.
Intracellular delivery of a cytolytic T-lymphocyte epitope peptide by pertussis toxin to major histocompatibility complex class I without involvement of the cytosolic class I antigen processing pathway.
Intracellular disassembly and activity of pertussis toxin require interaction with ATP.
Intracellular dynamics of alkaline phosphatase-containing granules in electropermeabilized human neutrophils.
Intracellular elevations of free calcium induced by activation of histamine H1 receptors in interphase and mitotic HeLa cells: hormone signal transduction is altered during mitosis.
Intracellular GTP gamma S restores the ability of morphine to hyperpolarize rat locus coeruleus neurons after blockade by pertussis toxin.
Intracellular mechanisms for alpha 1-adrenergic regulation of the transient outward current in rabbit atrial myocytes.
Intracellular mechanisms involved in leukotriene C4-stimulated adhesion of U-937 cells.
Intracellular pathways triggered by galanin to induce contraction of pig ileum smooth muscle cells.
Intracellular regulation of enzyme secretion from rat osteoclasts and evidence for a functional role in bone resorption.
Intracellular retention of the two isoforms of the D(2) dopamine receptor promotes endoplasmic reticulum disruption.
Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem.
Intracellular signal transduction by the extracellular calcium-sensing receptor of Xenopus melanotrope cells.
Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation.
Intracellular Signal-transducing elements involved in transendothelial migration of lymphoma cells.
Intracellular signaling leads to the hypertrophic effect of neuropeptide Y.
Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor.
Intracellular signaling pathway of FGF-2-modulated corneal endothelial cell migration during wound healing in vitro.
Intracellular signalling by binding sites for the antipsoriatic agent monomethylfumarate on human granulocytes.
Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function.
Intracellular trafficking and membrane translocation of pertussis toxin into host cells.
Intracellular Trafficking and Translocation of Pertussis Toxin.
Intracerebroventricular injection of antibodies directed against Gs alpha enhances the supraspinal antinociception induced by morphine, beta-endorphin and clonidine in mice.
Intracerebroventricular pertussis toxin enhances sensitivity to chemical convulsants and decreases the protective efficacy of carbamazepine in mice.
Intracerebroventricular pertussis toxin enhances sensitivity to N-methyl-D-aspartate-induced seizures in mice.
Intracerebroventricular treatment of mice with pertussis toxin induces hyperalgesia and enhances 3H-nitrendipine binding to synaptic membranes: similarity with morphine tolerance.
Intracerebroventricularly administered pertussis toxin blocks the central vasopressor action of neuropeptide Y(13-36) in the awake unrestrained male rat.
Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion.
Intradermal application of nociceptin increases vascular permeability in rats: the possible involvement of histamine release from mast cells.
Intrahippocampal injection of pertussis toxin blocks adenosine suppression of synaptic responses.
Intranasal murine model of Bordetella pertussis infection: II. Sequence variation and protection induced by a tricomponent acellular vaccine.
Intrathecal administration of low-dose nociceptin/orphanin FQ induces allodynia via c-Jun N-terminal kinase and monocyte chemoattractant protein-1.
Intrathecal pertussis toxin attenuates the morphine withdrawal syndrome in normal but not in arthritic rats.
Intrathecal pertussis toxin but not cyclic AMP blocks kappa opioid-induced antinociception in rat.
Intrathecal pertussis toxin induces thermal hyperalgesia: involvement of excitatory and inhibitory amino acids.
Intrathecal pertussis toxin produces hyperalgesia and allodynia in mice.
Intrathecal pertussis toxin treatment attenuates opioid antinociception and reduces high-affinity state of opioid receptors.
Intravesical therapy with pertussis toxin before radical cystectomy in patients with bladder cancer: a Phase I study.
Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice.
Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells.
Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.
Invasion of HeLa 229 cells by virulent Bordetella pertussis.
Invasiveness in hepatocyte and fibroblast monolayers and metastatic potential of T-cell hybridomas in mice.
Inverse agonism at adrenergic and opioid receptors: studies with wild type and constitutively active mutant receptors.
Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor.
Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: role of G protein and adenylyl cyclase activation.
Inverse regulation of leptin mRNA expression by short- and long-chain fatty acids in cultured bovine adipocytes.
Inversion of Ca2+ current modulation during recovery of neuroblastoma cells from pertussis toxin pretreatment.
Investigating pertussis toxin and its impact on vaccination.
Investigation in a murine model of possible mechanisms of enhanced local reactions to post-primary diphtheria-tetanus toxoid boosters in recipients of acellular pertussis-diphtheria-tetanus vaccine.
Investigation of a pertussis outbreak and comparison of two acellular booster pertussis vaccines in a junior school in South East England, 2019.
Investigation of brain sites mediating cannabinoid-induced antinociception in rats: evidence supporting periaqueductal gray involvement.
Investigation of cellular and humoral immune responses to whole cell and acellular pertussis vaccines.
Investigation of effects of different commercial source of bovine serum albumin on the binding of pertussis toxin to the glycoprotein fetuin.
Investigation of G protein-initiated, Ca2+-dependent release of ATP from endothelial cells.
Investigation of presumptive mobilization pathways for calcium in the steroidogenic action of big prothoracicotropic hormone.
Investigation of the Cellular Immune Response to Recombinant Fragments of Filamentous Hemagglutinin and Pertactin of Bordetella pertussis in BALB/c Mice.
Investigation of the lectin-like binding domains in pertussis toxin using synthetic peptide sequences. Identification of a sialic acid binding site in the S2 subunit of the toxin.
Investigations into neuropeptide Y-mediated presynaptic inhibition in cultured hippocampal neurones of the rat.
Involvement of 5-HT1B and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery.
Involvement of a botulinum toxin-sensitive 22-kDa G protein in stimulated exocytosis of human neutrophils.
Involvement of a Gardos-type potassium channel in head activator-induced mitosis of BON cells.
Involvement of a GTP-binding protein in mediation of serotonin and acetylcholine responses in Xenopus oocytes injected with rat brain messenger RNA.
Involvement of a GTP-binding protein in stimulating action of angiotensin II on calcium channels in vascular smooth muscle cells.
Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown.
Involvement of a guanine-nucleotide-binding protein-mediated mechanism in the enhancement of arachidonic acid liberation by phorbol 12-myristate 13-acetate and Ca2+ in saponin-permeabilized platelets.
Involvement of A pertussis Toxin Sensitive G-Protein in the Inhibition of Inwardly Rectifying K Currents by Platelet-Activating Factor in Guinea-Pig Atrial Cardiomyocytes.
Involvement of a pertussis toxin-sensitive G protein in the action of gastrin on gastric parietal cells.
Involvement of a pertussis toxin-sensitive G protein in the mitogenic signaling pathways of sphingosine 1-phosphate.
Involvement of a pertussis toxin-sensitive G protein in the regulation of angiotensinogen production by an angiotensin II analog in HepG2 cells.
Involvement of a pertussis toxin-sensitive G-protein in the pharmacological properties of septo-hippocampal neurones.
Involvement of a pertussis toxin-sensitive G-protein-coupled phospholipase A2 in lipopolysaccharide-stimulated prostaglandin E2 synthesis in cultured rat mesangial cells.
Involvement of a pertussis-toxin sensitive G protein in the induction of gene expression by insulin.
Involvement of a putative G-protein-coupled receptor and a branching pathway in argipressin (4-8) signal transduction in rat hippocampus.
Involvement of a signal transduction mechanism in ATP-induced mucin release from cultured airway goblet cells.
Involvement of a specific guanine nucleotide binding protein in receptor immunoglobulin stimulated inositol phospholipid hydrolysis.
Involvement of an inhibitory G-protein in the signal transduction pathway of maturation-inducing hormone (17 alpha,20 beta-dihydroxy-4-pregnen-3-one) action in rainbow trout (Oncorhynchus mykiss) oocytes.
Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells.
Involvement of both inhibitory and stimulatory guanine nucleotide binding proteins in the expression of chronic opiate regulation of adenylate cyclase activity in NG108-15 cells.
Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death.
Involvement of calcium and G proteins in the acute release of tissue-type plasminogen activator and von Willebrand factor from cultured human endothelial cells.
Involvement of calyculin A inhibitable protein phosphatases in the cyclic AMP signal transduction pathway of mouse corticotroph tumour (AtT20) cells.
Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line.
Involvement of cAMP-dependent protein kinase in mu-opioid modulation of NMDA-mediated synaptic currents.
Involvement of chemical mediators in nasal allergic responses of HDC-KO mice.
Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice.
Involvement of dihydropyridine-sensitive calcium channels in the GABAA potentiation of TRH-induced TSH release.
Involvement of distinct G-proteins in the action of vasopressin on rat glomerulosa cells.
Involvement of G i/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC-12 cells and cortical neurons.
Involvement of G protein betagamma-subunits in diverse signaling induced by G(i/o)-coupled receptors: study using the Xenopus oocyte expression system.
Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons.
Involvement of G proteins in the effect of carbachol and cholecystokinin in rat pancreatic islets.
Involvement of G proteins in the effect of insulin-like growth factor I on gonadotropin-induced rat granulosa cell differentiation.
Involvement of G(i) proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus.
Involvement of G(i/o) in the PAR-4-induced NO production in endothelial cells.
Involvement of G-protein alpha il subunits in activation of G-protein gated inward rectifying K+ channels (GIRK1) by human NPY1 receptors.
Involvement of G-protein betagamma subunits on the influence of inhibitory alpha2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens.
Involvement of G-proteins and adenylate cyclase in the action of gonad-stimulating substance on starfish ovarian follicle cells.
Involvement of G-proteins in chitosan-induced Anthraquinone synthesis in Rubia tinctorum
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
Involvement of Gi protein-dependent BKCa channel activation in ?2-adrenoceptor-mediated dilation of retinal arterioles in rats.
Involvement of Gi/o proteins and GIRK channels in the potentiation of morphine-induced spinal analgesia in acutely inflamed mice.
Involvement of Gialpha2 in sodium butyrate-induced erythroblastic differentiation of K562 cells.
Involvement of glutamate neurotransmission and N-methyl-d-aspartate receptor in the activation of midbrain dopamine neurons by 5-HT1A receptor agonists: an electrophysiological study in the rat.
Involvement of Gq/11 in both integrin signal-dependent and -independent pathways regulating endothelin-induced neural progenitor proliferation.
Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C.
Involvement of GTP-binding proteins in actin polymerization in human neutrophils.
Involvement of guanine nucleotide binding proteins in neutrophil activation and priming by GM-CSF.
Involvement of heterotrimeric G proteins in phagocytosis and recycling from the phagosomal compartment.
Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.
Involvement of intermediary metabolites in the pathway of extracellular Ca2+-induced mitogen-activated protein kinase activation in human fibroblasts.
Involvement of intracellular Ca2+ release mechanism in adenosine-induced cardiac Ca2+ current inhibition.
Involvement of kappa-opioids in the mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination.
Involvement of KCNQ2 subunits in [3H]dopamine release triggered by depolarization and pre-synaptic muscarinic receptor activation from rat striatal synaptosomes.
Involvement of MAP kinase and c-fos signaling in the inhibition of cell growth by somatostatin.
Involvement of MAP kinase signal transduction pathway in UVB-induced activation of macrophages in vitro.
Involvement of MAP kinases in the control of cPLA(2) and arachidonic acid release in endothelial cells.
Involvement of mitogen-activated protein kinases in the signal transduction pathway of bone marrow-derived macrophage activation in response to in vitro treatment with thymosin alpha 1.
Involvement of multiple P2Y receptors and signaling pathways in the action of adenine nucleotides diphosphates on human monocyte-derived dendritic cells.
Involvement of Ni protein in the functional coupling of the atrial natriuretic factor (ANF) receptor to adenylate cyclase in rat lung plasma membranes.
Involvement of nitric oxide and peptides in the inhibitory non-adrenergic, non-cholinergic (NANC) response in bovine mesenteric artery.
Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells.
Involvement of pertussis toxin sensitive G-proteins in conditioned fear-potentiated startle: possible involvement of the amygdala.
Involvement of pertussis toxin sensitive GTP binding protein in adenosine triphosphate and thrombin-mediated responses in vascular smooth muscle cells.
Involvement of pertussis toxin-sensitive and -insensitive G proteins in alpha-thrombin signalling on cultured human vascular smooth muscle cells.
Involvement of pertussis toxin-sensitive and -insensitive GTP-binding proteins in luteinizing hormone exocytosis distal to second messenger generation.
Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F).
Involvement of pertussis toxin-sensitive GTP-binding protein in prostaglandin F2 alpha- induced phosphoinositide hydrolysis in osteoblast-like cells.
Involvement of pertussis toxin-sensitive GTP-binding proteins in sphingosine 1-phosphate-induced activation of phospholipase C-Ca2+ system in HL60 leukemia cells.
Involvement of pertussis toxin-sensitive mechanism in retinoic acid-induced differentiation of human leukemic HL-60 cells.
Involvement of pertussis-toxin-sensitive G protein in muscarinic-receptor-mediated inhibition of K(+)-activated 4-nitrophenylphosphatase activity of cardiac sarcolemma.
Involvement of phosphoinositide turnover in tracheary element differentiation in Zinnia elegans L. cells.
Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells.
Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells.
Involvement of postsynaptic alpha 2-adrenoceptors and guanine nucleotide-binding protein in guanabenz-induced cardiovascular suppressant effects in the rat.
Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells.
Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injury.
Involvement of protein kinase A in the regulation of intracellular free calcium and phosphoinositide turnover in rat myometrium.
Involvement of protein kinase and G proteins in the signal transduction of benzophenanthridine alkaloid biosynthesis.
Involvement of protein kinase C activation in alpha 2-adrenoceptor-mediated contractions of rabbit saphenous vein.
Involvement of protein kinase C and RhoA in protease-activated receptor 1-mediated F-actin reorganization and cell growth in rat cardiomyocytes.
Involvement of Protein Kinase C and RhoA in Protease-Activated Receptor 1-Mediated F-Actin Reorganization and Cell Growth in Rat Cardiomyocytes.
Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium.
Involvement of protein kinase C in the UTP-mediated potentiation of cyclic AMP accumulation in mouse J774 macrophages.
Involvement of protein kinase-C in the effect of angiotensin-II on adenosine 3',5'-monophosphate production in lactotroph cells.
Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.
Involvement of Rho and p38 MAPK in endothelin-1-induced expression of PGHS-2 mRNA in osteoblast-like cells.
Involvement of Rho and tyrosine kinase in angiotensin II-induced actin reorganization in mesothelial cells.
Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells.
Involvement of signal transducing GTP-binding proteins in renal artery alpha 1-adrenoceptor mediated smooth muscle contraction.
Involvement of signaling pathways in bovine sperm motility, and effect of ergot alkaloids.
Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes.
Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P.
Involvement of the 90-kDa Heat Shock Protein (Hsp-90) in CB2 Cannabinoid Receptor-Mediated Cell Migration: A New Role of Hsp-90 in Migration Signaling of a G Protein-Coupled Receptor.
Involvement of the beta gamma subunits of inhibitory GTP-binding protein in chemoattractant receptor-mediated potentiation of cyclic AMP formation in guinea pig neutrophils.
Involvement of the betagamma subunits of G proteins in the cAMP response induced by stimulation of the histamine H1 receptor.
Involvement of the carboxyl terminus of the third intracellular loop of the cannabinoid CB1 receptor in constitutive activation of Gs.
Involvement of the extracellular signal regulated kinase pathway in hydrocarbon-induced reactive oxygen species formation in human neutrophil granulocytes.
Involvement of the Gi/o/cGMP/PKG pathway in the AT2-mediated inhibition of outer cortex proximal tubule Na+-ATPase by Ang-(1-7).
Involvement of the M2 muscarinic receptor in contractions of the guinea pig trachea, guinea pig esophagus, and rat fundus.
Involvement of the mu-opiate receptor in peripheral analgesia.
Involvement of the peroxisome proliferator-activated receptor (PPAR) alpha in vascular response of endocannabinoids in the bovine ophthalmic artery.
Involvement of the pertussis toxin-sensitive GTP-binding protein in regulation of expression and function of granulocyte complement receptor type 1 and type 3.
Involvement of the Rho-kinase/myosin light chain kinase pathway on human monocyte chemotaxis induced by ATL-1, an aspirin-triggered lipoxin A4 synthetic analog.
Involvement of tyrosine kinase in capacitative Ca2+ entry pathway in rat glioma C6 cells.
Involvement of tyrosine kinase in growth factor-induced phospholipase C activation in NIH3T3 cells.
Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.
Ion fluxes through the progesterone-activated channel of the sperm plasma membrane.
Ionizing Radiation Increases Adhesiveness of Human Aortic Endothelial Cells via a Chemokine-Dependent Mechanism.
Ionomycin induces prostaglandin E2 formation in murine osteoblastic MC3T3-E1 cells via mechanisms independent of its ionophoric nature.
Ionotropic histamine receptors and H2 receptors modulate supraoptic oxytocin neuronal excitability and dye coupling.
Is a guanine nucleotide-binding protein involved in excitation-contraction coupling in skeletal muscle?
Is a rise in intracellular concentration of free calcium necessary or sufficient for stimulated cytoskeletal-associated actin?
Is autism a G-alpha protein defect reversible with natural vitamin A?
Is the heterologous expression of metabotropic glutamate receptors (mGluRs) an appropriate method to study the mGluR function? Experience with human embryonic kidney 293 cells transfected with mGluR1.
Is the inhibitory effect of somatostatin on the heart due to K+ channel activation?
Ischemia of rat brain decreases pertussis toxin-catalyzed [32P]ADP ribosylation of GTP-binding proteins (Gi1 and G0) in membranes.
Ischemic preconditioning is associated with a delay in ischemia-induced reduction of beta-adrenergic signal transduction in rabbit hearts.
Islet amyloid polypeptide regulates multiple steps in stimulus-secretion coupling of beta cells in rat pancreatic islets.
Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase.
Islet-activating protein inhibits leukotriene D4- and leukotriene C4- but not bradykinin- or calcium ionophore-induced prostacyclin synthesis in bovine endothelial cells.
Islet-activating protein inhibits the beta-adrenergic receptor facilitation elicited by gamma-aminobutyric acidB receptors.
Islet-activating protein prevents nicotinic acid-induced GTPase stimulation and GTP but not GTP gamma S-induced adenylate cyclase inhibition in rat adipocytes.
Islet-activating protein, pertussis toxin, inhibits Ca2+-induced and guanine nucleotide-dependent releases of histamine and arachidonic acid from rat mast cells.
Islet-activating protein, pertussis toxin: a specific uncoupler of receptor-mediated inhibition of adenylate cyclase.
Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi.
Isoflurane preconditioning decreases glutamate receptor overactivation-induced Purkinje neuronal injury in rat cerebellar slices.
Isoflurane preconditions myocardium against infarction via activation of inhibitory guanine nucleotide binding proteins.
Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals.
Isolation and characterization of natural human IgG with a morphine-like activity.
Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides.
Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates.
Isolation of pertussis toxin subunit proteins by reverse-phase high-performance liquid chromatography and reconstitution of the holotoxin molecule.
Isolation of three types of Gi from bovine spleen.
Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum.
Isomorphous binding of mercury-substituted thiosaccharides to pertussis toxin crystals yields crystallographic phases.
Isoprenaline can activate the acetylcholine-induced K+ current in canine atrial myocytes via Gs-derived betagamma subunits.
Isoprenaline-induced increase in the 40/41 kDa pertussis toxin substrates and functional consequences on contractile response in rat heart.
Isoproterenol and cAMP regulation of the human brain natriuretic peptide gene involves Src and Rac.
Isoproterenol and GTP gamma S inhibit L-type calcium channels of differentiating rat skeletal muscle cells.
Isoproterenol enhances a calcium-independent potassium current in mouse anterior pituitary tumor cells.
Isoproterenol modulates the calcium channels through two different mechanisms in smooth-muscle cells from rabbit portal vein.
Isovaleric acid ameliorates ovariectomy-induced osteoporosis by inhibiting osteoclast differentiation.
Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits.
Juxtaglomerular cell CaSR stimulation decreases renin release via activation of the PLC/IP(3) pathway and the ryanodine receptor.
K+ channel and adenylate cyclase involvement in regulation of Ca2+-evoked release of [3H]dopamine from synaptosomes.
K+ channel involvement in induction of synaptic enhancement by mast cell degranulating (MCD) peptide.
K-ras transformation greatly increases the toxin-dependent ADP-ribosylation of GTP binding proteins in thyroid cells. Involvement of an inhibitor of the ADP-ribosylation reaction.
Kainate receptor modulation of GABA release involves a metabotropic function.
Kainate receptor modulation of glutamatergic synaptic transmission in the CA2 region of the hippocampus.
Kainate Receptor-Mediated Depression of Glutamate Release Involves Protein Kinase A in the Cerebellum.
Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus.
Kainate receptors depress excitatory synaptic transmission at CA3-->CA1 synapses in the hippocampus via a direct presynaptic action.
Kaposi sarcoma-associated herpes virus (KSHV) G protein-coupled receptor (vGPCR) activates the ORF50 lytic switch promoter: a potential positive feedback loop for sustained ORF50 gene expression.
Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor signals through multiple pathways in endothelial cells.
Kappa opiate agonists inhibit Ca2+ influx in rat spinal cord-dorsal root ganglion cocultures. Involvement of a GTP-binding protein.
kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins.
Kappa opioid receptor-mediated suppression of voltage-activated potassium current in a catecholaminergic neuronal cell line.
Kappa- and delta-opioids block sympathetically dependent hyperalgesia.
kappa-Opioid agonist modulation of [3H]thymidine incorporation into DNA: evidence for the involvement of pertussis toxin-sensitive G protein-coupled phosphoinositide turnover.
kappa-Opioid inhibits catecholamine biosynthesis in PC12 rat pheochromocytoma cell.
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
kappa-opioid receptor stimulation inhibits cardiac hypertrophy induced by beta1-adrenoceptor stimulation in the rat.
kappa-Opioid receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments.
kappa-Opioid tolerance and dependence in cultures of dopaminergic midbrain neurons.
KATP channels in the nodose ganglia mediate the orexigenic actions of ghrelin.
Khellin, but not 8-methoxypsoralen, inhibits adenylyl cyclase system in HeLa cells.
Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells.
Kinetic basis for the voltage-dependent inhibition of N-type calcium current by somatostatin and norepinephrine in chick sympathetic neurons.
Kinetic isotope effect characterization of the transition state for oxidized nicotinamide adenine dinucleotide hydrolysis by pertussis toxin.
Kinetics and reversibility of thyrotropin-releasing hormone-stimulated guanine nucleotide exchange in membranes from GH4C1 cells.
Kinetics of asthma- and allergy-associated immune response gene expression in peripheral blood mononuclear cells from vaccinated infants after in vitro re-stimulation with vaccine antigen.
Kinetics of IL-17- and interferon-gamma-producing PLPp-specific CD4 T cells in EAE induced by coinjection of PLPp/IFA with pertussis toxin in SJL mice.
Kinetics of maternal pertussis-specific antibodies in infants of mothers vaccinated with tetanus, diphtheria and acellular pertussis (Tdap) during pregnancy.
Kinetics of the IgG antibody response to pertussis toxin after infection with B. pertussis.
Knockdown of Inhibitory Guanine Nucleotide Binding Protein Gi?-2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats.
Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the ?1-adrenoceptor-mediated inotropic response.
Kombucha ameliorates experimental autoimmune encephalomyelitis through activation of Treg and Th2 cells.
KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation.
Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35.
Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions.
L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation.
L-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor.
L-channel modulation by alpha-1 adrenoceptor activation in neonatal rat ventricular cells: intracellular mechanisms.
L-glutamate and acetylcholine mobilise Ca2+ from the same intracellular pool in cerebellar granule cells using transduction mechanisms with different Ca2+ sensitivities.
L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration.
Label-free detection and identification of protein ligands captured by receptors in a polymerized planar lipid bilayer using MALDI-TOF MS.
Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with G(i)-protein pathway activation.
Label-free versus conventional cellular assays: Functional investigations on the human histamine H1 receptor.
Laboratory diagnosis of pertussis infections: the role of PCR and serology.
Lack of effect of pertussis toxin on TNF-alpha-induced formation of reactive oxygen intermediates by human neutrophils.
Lack of endogenous adenosine receptor activation explains the insensitivity of neonatal rat Leydig cells to treatment with pertussis toxin.
Lack of involvement of G proteins in the activation of cardiac CFTR Cl- current by genistein.
Lack of involvement of pertussis toxin-sensitive G-proteins in norepinephrine-induced vasoconstriction of rat aorta smooth muscle.
Lack of stereospecificity in lysophosphatidic acid enantiomer-induced calcium mobilization in human erythroleukemia cells.
Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells.
Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway.
Lamellipod extension and K+ current in osteoclasts are regulated by different types of G proteins.
Laminin enhances beta(2)-adrenergic receptor stimulation of L-type Ca(2+) current via cytosolic phospholipase A(2) signalling in cat atrial myocytes.
Lanthanum enhances in vitro osteoblast differentiation via pertussis toxin-sensitive gi protein and ERK signaling pathway.
Lanthanum suppresses osteoblastic differentiation via pertussis toxin-sensitive G protein signaling in rat vascular smooth muscle cells.
Latrophilin-2 is a novel component of the epithelial-mesenchymal transition within the atrioventricular canal of the embryonic chicken heart.
Latrotoxin stimulates secretion in permeabilized cells by regulating an intracellular Ca2+ - and ATP-dependent event: a role for protein kinase C.
LDL increases (CA++)i in human endothelial cells and augments thrombin-induced cell signalling.
LDL stimulates mitogen-activated protein kinase phosphatase-1 expression, independent of LDL receptors, in vascular smooth muscle cells.
Lectin domains in the toxin of Bordetella pertussis: selectin mimicry linked to microbial pathogenesis.
Lectin-like binding of pertussis toxin to a 165-kilodalton Chinese hamster ovary cell glycoprotein.
Lectinlike properties of pertussis toxin.
Leptin Elicits LTC4 Synthesis by Eosinophils Mediated by Sequential Two-Step Autocrine Activation of CCR3 and PGD2 Receptors.
Lethal infection by Bordetella pertussis mutants in the infant mouse model.
Letter to the Editor: An Alternative Temperature-based Histamine-sensitisation Test for Absence of Residual Pertussis Toxin in Acellular Pertussis Vaccines.
Leu27 insulin-like growth factor-II, an insulin-like growth factor-II analog, attenuates depolarization-evoked GABA release from adult rat hippocampal and cortical slices.
Leucine Facilitates Insulin Signaling through a G?i Protein-dependent Signaling Pathway in Hepatocytes.
Leucine-2-alanine enkephalin induced delta opioid receptors internalization expressed stably in CHO cells.
Leukocyte infiltration, but not neurodegeneration, in the CNS of transgenic mice with astrocyte production of the CXC chemokine ligand 10.
Leukotactin-1-induced ERK activation is mediated via Gi/Go protein/PLC/PKC delta/Ras cascades in HOS cells.
Leukotactin-1/CCL15 induces cell migration and differentiation of human eosinophilic leukemia EoL-1 cells through PKCdelta activation.
Leukotriene B(4) enhances tumour necrosis factor-alpha-induced CCL27 production in human keratinocytes.
Leukotriene B4 activates the NADPH oxidase in eosinophils by a pertussis toxin-sensitive mechanism that is largely independent of arachidonic acid mobilization.
Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis.
Leukotriene B4 mediates vascular smooth muscle cell migration through ?v?3 integrin transactivation.
Leukotriene B4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation.
Leukotriene B4 stimulates human monocyte-derived dendritic cell chemotaxis.
Leukotriene B4 stimulation of phagocytes results in the formation of inositol 1,4,5-trisphosphate. A second messenger for Ca2+ mobilization.
Leukotriene B4 stimulation of phosphatidylinositol turnover in macrophages and inhibition by pertussis toxin.
Leukotriene D(4) activates MAPK through a Ras-independent but PKCepsilon-dependent pathway in intestinal epithelial cells.
Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor.
Leukotriene D(4)-induced Rho-mediated actin reorganization in human bronchial smooth muscle cells.
Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells.
Leukotriene D4 and E4 induce transmembrane signaling in human epithelial cells. Single cell analysis reveals diverse pathways at the G-protein level for the influx and the intracellular mobilization of Ca2+.
Leukotriene D4 induced calcium changes in U937 cells may utilize mechanisms additional to inositol phosphate production that are pertussis toxin insensitive but are blocked by phorbol myristate acetate.
Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane.
Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts.
Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle.
Leukotriene D4-induced proliferation of glomerular epithelial cells: PKC- and Na+-H+ exchanger-mediated response.
Leukotriene-D4 induced cell shrinkage in Ehrlich ascites tumor cells.
Levels of anti-pertussis antibodies related to protection after household exposure to Bordetella pertussis.
LH action in the Leydig cell: modulation by angiotensin II and corticotropin releasing hormone, and regulation of P450(17) alpha mRNA.
LH release is facilitated by agents that alter cyclic AMP-generating system.
Lidocaine enhances Galphai protein function.
Ligand binding and functional characterization of muscarinic acetylcholine receptors on the TE671/RD human cell line.
Ligand Binding and Functional Properties of the Rat Somatostatin Receptor SSTR4 Stably Expressed in Chinese Hamster Ovary Cells.
Ligand binding and G protein coupling of muscarinic receptors in airway smooth muscle.
Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance.
Ligand-dependent autophosphorylation of the insulin receptor is positively regulated by Gi-proteins.
Ligand-independent activation of peroxisome proliferator-activated receptor-gamma by insulin and C-peptide in kidney proximal tubular cells: dependent on phosphatidylinositol 3-kinase activity.
Ligand-induced adhesion to activated endothelium and to vascular cell adhesion molecule-1 in lymphocytes transfected with the N-formyl peptide receptor.
Ligand-induced alpha2-adrenoceptor endocytosis: relationship to Gi protein activation.
Ligand-induced changes in surface mu-opioid receptor number: relationship to G protein activation?
Ligand-induced formation of the leukotriene B4 receptor-G protein complex of human polymorphonuclear leukocytes.
Ligand-receptor dynamics and signal amplification in the neutrophil.
Ligand-specific stimulation/inhibition of cAMP formation by a novel endothelin receptor subtype.
Ligation of CD23 triggers cyclic AMP generation in human B lymphocytes.
Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages.
Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor.
Light activation of phosphatidylethanolamine N-methyltransferase in rod outer segments and its modulation by association states of transducin.
Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins.
Light and norepinephrine similarly prevent damping of the melatonin rhythm in cultured chick pineal cells: regulation of coupling between the pacemaker and overt rhythms?
Light transduction in invertebrate hyperpolarizing photoreceptors: possible involvement of a Go-regulated guanylate cyclase.
Light-dependent GTP-binding proteins in squid photoreceptors.
Light-induced changes in the content of inositol phosphates in squid (Loligo pealei) retina.
Light-induced, GTP-binding protein mediated membrane currents of Xenopus oocytes injected with rhodopsin of cephalopods.
Limited distribution of pertussis toxin in rat brain after injection into the lateral cerebral ventricles.
Linkage between somatostatin and acid secretion: evidence from use of pertussis toxin.
Lipid and membrane interactions of neuropeptide Y.
Lipid modification at the N terminus of photoreceptor G-protein alpha-subunit.
Lipid peroxidation product 4-hydroxy-2-nonenal acts synergistically with serotonin in inducing vascular smooth muscle cell proliferation.
Lipocortin 1 and the control of cPLA2 activity in A549 cells. Glucocorticoids block EGF stimulation of cPLA2 phosphorylation.
Lipocortin-1 and the control of arachidonic acid release in cell signalling. Glucocorticoids (changed from glucorticoids) inhibit G protein-dependent activation of cPLA2 activity.
Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells.
Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins.
Lipopolysaccharide induces autotaxin expression in human monocytic THP-1 cells.
Lipopolysaccharide induces interleukin-6 release from rat peritoneal macrophages in vitro: evidence for a novel mechanism.
Lipopolysaccharide interaction with S2 subunit of pertussis toxin.
Lipopolysaccharide priming of human neutrophils for an enhanced respiratory burst. Role of intracellular free calcium.
Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937.
Lipopolysaccharide structure-function relationship in activation versus reprogramming of mouse peritoneal macrophages.
Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis differently modulate human dendritic cell functions resulting in divergent prevalence of Th17-polarized responses.
Lipopolysaccharides in a traditional pertussis vaccine.
Lipoprotein(a) stimulates growth of human mesangial cells and induces activation of phospholipase C via pertussis toxin-sensitive G proteins.
Lipoprotein-stimulated surfactant secretion in alveolar type II cells: mediation by heterotrimeric G proteins.
Lipoteichoic acid-stimulated p42/p44 MAPK activation via Toll-like receptor 2 in tracheal smooth muscle cells.
Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion.
Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors.
Lipoxin A4 induces hyperadhesiveness in human endothelial cells for neutrophils.
Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor.
Lipoxin A4 stimulates a cytosolic Ca2+ increase in human bronchial epithelium.
Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation.
Lipoxins are potential endogenous antiinflammatory mediators in asthma.
Lithium activates mammalian Na+/H+ exchangers: isoform specificity and inhibition by genistein.
Lithium administration modulates platelet Gi in humans.
Lithium does not alter ADP-ribosylation of Gi/Go catalyzed by pertussis toxin in rat brain.
Lithium stimulation of rat pancreatic beta-cell replication is mediated through pertussis toxin-sensitive GTP-binding proteins and occurs independently of Ca2+ influx, cAMP, or protein kinase C activation.
Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver.
Local anesthetic effects on priming and activation of human neutrophils.
Local injection of pertussis toxin attenuates morphine withdrawal excitation of rat supraoptic nucleus neurones.
Local massage after vaccination enhances the immunogenicity of diphtheria-tetanus-pertussis vaccine.
Local reactions and IgE antibodies to pertussis toxin after acellular diphtheria-tetanus-pertussis immunization.
Localisation of a receptor-recognition domain on the S3 subunit of pertussis toxin by peptide mapping.
Localization and characterization of the subtypes(s) of muscarinic receptor involved in prostacyclin synthesis in rabbit heart.
Localization of a region of the S1 subunit of pertussis toxin required for efficient ADP-ribosyltransferase activity.
Localization of G alpha 0 to growth cones in PC12 cells: role of G alpha 0 association with receptors and G beta gamma.
Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.
Localization of IP in rabbit kidney and functional role of the PGI(2)/IP system in cortical collecting duct.
Localization of marginal zone macrophages is regulated by C-C chemokine ligands 21/19.
Localization of several G-protein subunits to the apical and basolateral membranes of cortical tubular cells from the rat kidney.
Localization of the GTP-binding protein Gi alpha in myelomonocytic progenitor cells is regulated by proliferation (GM-CSF, IL-3) and differentiation (TNF) signals.
Localization of the promoter for the ptl genes of Bordetella pertussis, which encode proteins essential for secretion of pertussis toxin.
Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6.
Long lasting inhibition of adenylyl cyclase selectively mediated by inositol 1,4,5-trisphosphate-evoked calcium release.
Long term beta-adrenoceptor-mediated up-regulation of Gi alpha and G(o) alpha mRNA levels and pertussis toxin-sensitive guanine nucleotide-binding proteins in rat heart.
Long term serologic follow-up after pertussis immunization.
Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors.
Long-term depression of a sympathetic ganglionic response to opioids by prolonged synaptic activity and by phorbol esters.
Long-term functional impairment of hemopoietic progenitor cells engineered to express the S1 catalytic subunit of pertussis toxin.
Long-term human serum antibody responses after immunization with whole-cell pertussis vaccine in France.
Long-term neuroleptic treatments counteract dopamine D2 agonist inhibition of adenylate cyclase but do not affect pertussis toxin ADP-ribosylation in the rat brain.
Losartan-sensitive AII receptors linked to depolarization-dependent cortisol secretion through a novel signaling pathway.
Loss of activation of Gs but not Gi following expression of an alpha2A-adrenoceptor-Gi1alpha fusion protein.
Loss of beta-adrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger.
Loss of dendritic cell migration and impaired resistance to Leishmania donovani infection in mice deficient in CCL19 and CCL21.
Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries.
Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.
Loss of microglial ramification in microglia-astrocyte cocultures: involvement of adenylate cyclase, calcium, phosphatase, and Gi-protein systems.
Loss of multi-epitope specificity in memory CD4(+) T cell responses to B. Pertussis with age.
Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.
Loss of vascular adenosine A1 receptors with age in the rat heart.
Low density lipoprotein and apoprotein B induce increases in inositol trisphosphate and cytosolic free Ca2+ via pertussis toxin-sensitive GTP-binding protein in vascular smooth muscle cells.
Low Detection Rate of Bordetella pertussis Using the BioFire FilmArray Respiratory Panel 2plus.
Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans.
Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor.
Low levels of antipertussis antibodies plus lack of history of pertussis correlate with susceptibility after household exposure to Bordetella pertussis.
Low levels of pertussis toxin adenosine diphosphate ribosylation in the schizophrenic brain.
Low pertussis antibody levels in maternal and umbilical cord blood samples in Turkey.
Low pertussis toxin antibody levels in two regional cohorts of Canadian pregnant women.
Low-affinity receptor-mediated induction of superoxide by N-formyl-methionyl-leucyl-phenylalanine and WKYMVm in IMR90 human fibroblasts.
Low-density lipoprotein (LDL) binds to a G-protein coupled receptor in human platelets. Evidence that the proaggregatory effect induced by LDL is modulated by down-regulation of binding sites and desensitization of its mediated signaling.
Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription.
Low-Density Lipoprotein Induced Expression of Connective Tissue Growth Factor via Transactivation of Sphingosine 1-Phosphate Receptors in Mesangial Cells.
LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance.
LPA is a novel lipid regulator of mesangial cell hexokinase activity and HKII isoform expression.
LPA modulates monocyte migration directly and via LPA-stimulated endothelial cells.
LPA protects intestinal epithelial cells from apoptosis by inhibiting the mitochondrial pathway.
LPA(1) -induced migration requires nonmuscle myosin II light chain phosphorylation in breast cancer cells.
LPA1 mediates antidepressant-induced ERK1/2 signalling and protection from oxidative stress in glial cells.
LPA1 receptor-mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction.
LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.
LPA2 receptor mediates mitogenic signals in human colon cancer cells.
LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Gi? dependent PI-3kinase signalling.
LPS induces eosinophil migration via CCR3 signaling through a mechanism independent of RANTES and Eotaxin.
Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct.
Lupinus mutabilis Extract Exerts an Anti-Diabetic Effect by Improving Insulin Release in Type 2 Diabetic Goto-Kakizaki Rats.
Luteinizing hormone (LH) drives diverse intracellular calcium second messenger signals in isolated porcine ovarian thecal cells: preferential recruitment of intracellular Ca2+ oscillatory cells by higher concentrations of LH.
Luteinizing hormone secretion is enhanced by pertussis toxin, cholera toxin, and forskolin. Evidence for the involvement of the cyclic AMP-generating system.
Luteinizing hormone-releasing hormone (LHRH) attenuates morphine-induced inhibition of cyclic AMP (cAMP) in opioid-responsive SK-N-SH cells.
Luteinizing hormone/choriogonadotropin-dependent, cholera toxin-catalyzed adenosine 5'-diphosphate (ADP)-ribosylation of the long and short forms of Gs alpha and pertussis toxin-catalyzed ADP-ribosylation of Gi alpha*.
LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation.
Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet.
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.
Lymphocyte proliferation induced by pertussis toxin utilizes a pathway parallel to transforming growth factor-beta-sensitive growth.
Lymphocyte receptors for pertussis toxin.
Lymphocyte trafficking through the blood-brain barrier is dependent on endothelial cell heterotrimeric G-protein signaling.
Lymphokine secretion and cytotoxic activity of human CD4+ T-cell clones against Bordetella pertussis.
Lymphotoxin induces secretion of granule proteins from adherent neutrophils: possible role of intracellular free calcium.
Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins.
Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors.
Lysophosphatidic acid accelerates the development of human mast cells.
Lysophosphatidic acid activates ?-catenin/T cell factor signaling, which contributes to the suppression of apoptosis in H19-7 cells.
Lysophosphatidic acid activates NF-kappaB in fibroblasts. A requirement for multiple inputs.
Lysophosphatidic acid activates nuclear factor kappa B and induces proinflammatory gene expression in endothelial cells.
Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism.
Lysophosphatidic acid alters cerebrovascular reactivity in piglets.
Lysophosphatidic acid and bFGF control different modes in proliferating myoblasts.
Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells.
Lysophosphatidic acid and intracellular signalling in vascular smooth muscle cells.
Lysophosphatidic acid and receptor-mediated activation of endothelial nitric-oxide synthase.
Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing.
Lysophosphatidic acid as a mediator for proinflammatory agonists in a human corneal epithelial cell line.
Lysophosphatidic acid as a novel cell survival/apoptotic factor.
Lysophosphatidic acid as a regulator of endothelial/leukocyte interaction.
Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gels.
Lysophosphatidic acid cooperates with 1alpha,25(OH)2D3 in stimulating human MG63 osteoblast maturation.
Lysophosphatidic acid enhanced the angiogenic capability of human chondrocytes by regulating Gi/NF-kB-dependent angiogenic factor expression.
Lysophosphatidic acid in malignant ascites stimulates migration of human mesenchymal stem cells.
Lysophosphatidic acid increases soluble ST2 expression in mouse lung and human bronchial epithelial cells.
Lysophosphatidic acid induced nuclear translocation of nuclear factor-kappaB in Panc-1 cells by mobilizing cytosolic free calcium.
Lysophosphatidic acid induces a pertussis toxin-sensitive Ca(2+)-activated Cl- current in Xenopus laevis oocytes.
Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells.
Lysophosphatidic acid induces chemotaxis, oxygen radical production, CD11b up-regulation, Ca2+ mobilization, and actin reorganization in human eosinophils via pertussis toxin-sensitive G proteins.
Lysophosphatidic acid induces human natural killer cell chemotaxis and intracellular calcium mobilization.
Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho.
Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells.
Lysophosphatidic acid induces osteocyte dendrite outgrowth.
Lysophosphatidic acid induces rapid and sustained decreases in epidermal growth factor receptor binding via different signaling pathways in BEAS-2B airway epithelial cells.
Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes.
Lysophosphatidic acid induction of tissue factor expression in aortic smooth muscle cells.
Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells.
Lysophosphatidic acid is a mediator of Trp-Lys-Tyr-Met-Val-d-Met-induced calcium influx.
Lysophosphatidic acid is an osteoblast mitogen whose proliferative actions involve G(i) proteins and protein kinase C, but not P42/44 mitogen-activated protein kinases.
Lysophosphatidic acid mimics serum-induced sensitization of cyclic AMP accumulation.
Lysophosphatidic acid modulates alpha(1b)-adrenoceptor phosphorylation and function: roles of Gi and phosphoinositide 3-kinase.
Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin.
Lysophosphatidic acid possesses dual action in cell proliferation.
Lysophosphatidic acid potentiates ACh receptor currents by G-protein-mediated activation of protein kinase C.
Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase.
Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemotherapy-induced apoptosis.
Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.
Lysophosphatidic acid rapidly induces protein kinase D activation through a pertussis toxin-sensitive pathway.
Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells.
Lysophosphatidic acid receptor-2 (LPA2)-mediated signaling enhances chemoresistance in melanoma cells treated with anticancer drugs.
Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake.
Lysophosphatidic acid regulation of cyclic AMP accumulation in cultured human airway smooth muscle cells.
Lysophosphatidic acid sensitizes mechanical stress-induced Ca2+ response via activation of phospholipase C and tyrosine kinase in cultured smooth muscle cells.
Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway?
Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival.
Lysophosphatidic acid stimulates calcium transients in enteric glia.
Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes.
Lysophosphatidic acid stimulates intestinal restitution via cytoskeletal activation and remodeling.
Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i/o) pathway.
Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway.
Lysophosphatidic acid stimulates p21-activated kinase in vascular smooth muscle cells.
Lysophosphatidic acid stimulates phospholipase D activity and cell proliferation in PC-3 human prostate cancer cells.
Lysophosphatidic acid stimulates protein kinase C isoforms alpha, beta, epsilon, and zeta in a pertussis toxin sensitive pathway in vascular smooth muscle cells.
Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells.
Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21.
Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils.
Lysophosphatidic acid triggers cathepsin B-mediated invasiveness of human endometriotic cells.
Lysophosphatidic acid-induced activation of protein Ser/Thr kinases in cultured rat 3Y1 fibroblasts. Possible involvement in rho p21-mediated signalling.
Lysophosphatidic acid-induced association of SHP-2 with SHPS-1: roles of RHO, FAK, and a SRC family kinase.
Lysophosphatidic acid-induced Ca(2+) mobilization in the neural retina of chick embryo.
Lysophosphatidic acid-induced calcium mobilization and proliferation in kidney proximal tubular cells.
Lysophosphatidic acid-induced changes in cAMP profiles in young and senescent human fibroblasts as a clue to the ageing process.
Lysophosphatidic acid-induced membrane ruffling and brain-derived neurotrophic factor gene expression are mediated by ATP release in primary microglia.
Lysophosphatidic acid-induced neurite retraction in PC12 cells: neurite-protective effects of cyclic AMP signaling.
Lysophosphatidic acid-induced oxidized low-density lipoprotein uptake is class A scavenger receptor-dependent in macrophages.
Lysophosphatidic acid-induced proliferation-related signals in astrocytes.
Lysophosphatidic acid-induced, pertussis toxin-sensitive nociception through a substance P release from peripheral nerve endings in mice.
Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation.
Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and Egr-1: a critical role for the mitogen-activated protein kinase p38 and for Rho proteins.
Lysophosphatidylcholine activates mesangial cell PKC and MAP kinase by PLCgamma-1 and tyrosine kinase-Ras pathways.
Lysophosphatidylcholine activates p38 and p42/44 mitogen-activated protein kinases in monocytic THP-1 cells, but only p38 activation is involved in its stimulated chemotaxis.
Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes.
Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance.
Lysophosphatidylcholine induces changes in physicochemical, morphological, and functional properties of mouse zona pellucida: a possible role of phospholipase A2 in sperm-zona pellucida interaction.
Lysophosphatidylcholine induces mast cell secretion and protein kinase C activation.
Lysophosphatidylcholine is a regulator of tyrosine kinase activity and intracellular Ca(2+) level in Jurkat T cell line.
Lysophosphatidylcholine modifies G protein-dependent signaling in porcine endothelial cells.
Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines.
Lysophosphatidylcholine stimulates MAP kinase activity in rat vascular smooth muscle cells.
Lysophosphatidylcholine- and MCP-1-induced chemotaxis of monocytes requires potassium channel activity.
Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK.
Lysophosphatidylethanolamine stimulates chemotactic migration and cellular invasion in SK-OV3 human ovarian cancer cells: involvement of pertussis toxin-sensitive G-protein coupled receptor.
Lysophosphatidylethanolamine utilizes LPA1 and CD97 in MDA-MB-231 breast cancer cells.
Lysophosphatidylglycerol stimulates chemotactic migration and tube formation in human umbilical vein endothelial cells.
Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells.
Lysophosphatidylserine increases membrane potentials in rat C6 glioma cells.
Lysophosphatidylserine induces calcium signaling through Ki16425/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells.
Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells.
Lysophosphatidylserine Stimulates L2071 Mouse Fibroblast Chemotactic Migration via a Process Involving Pertussis Toxin-Sensitive Trimeric G-Proteins.
Lysophosphatidylserine stimulates leukemic cells but not normal leukocytes.
Lysophospholipids and chemokines activate distinct signal transduction pathways in T helper 1 and T helper 2 cells.
Lysophospholipids control integrin-dependent adhesion in splenic B cells through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11).
Lysophospholipids elevate [Ca2+]i and trigger exocytosis in bovine chromaffin cells.
Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism.
Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A.
LysoPtdOH Enhances CXCL16 Production Stimulated by LPS from Macrophages and Regulates T cell Migration.
Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized rats.
Lysozyme, a mediator of sepsis, impairs the cardiac neural adrenergic response by nonendothelial release of NO and inhibitory G protein signaling.
M(2) and M(3) muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice.
m-chlorophenylpiperazine and m-trifluoromethylphenylpiperazine are partial agonists at cloned 5-HT2A receptors expressed in fibroblasts.
M-current suppression in PC12 cells by bradykinin is mediated by a pertussis toxin-insensitive G-protein and modulated by intracellular calcium.
M1 acetylcholine receptor-mediated phosphatidylinositol turnover in adult and senescent rat brain slices.
M1 muscarinic receptors increase calcium current and phosphoinositide turnover in guinea-pig ventricular cardiocytes.
M1, M3 and M5 muscarinic receptors stimulate mitogen-activated protein kinase.
M2 muscarinic autoreceptors modulate acetylcholine release in prefrontal cortex of C57BL/6J mouse.
M2 muscarinic receptor-mediated inhibition of the Ca2+ current in rat magnocellular cholinergic basal forebrain neurones.
M2 muscarinic receptors in pontine reticular formation of C57BL/6J mouse contribute to rapid eye movement sleep generation.
M2 muscarinic receptors induce airway smooth muscle activation via a dual, Gbetagamma-mediated inhibition of large conductance Ca2+-activated K+ channel activity.
M2, M3, and M4 receptor subtypes contribute to muscarinic potentiation of GABAergic inputs to spinal dorsal horn neurons.
m3 Muscarinic receptor-induced and Gi-mediated heterologous potentiation of phospholipase C stimulation: role of phosphoinositide synthesis.
M3 muscarinic receptors on murine HSDM1C1 cells: further functional, regulatory, and receptor binding studies.
M4 muscarinic receptor activation modulates calcium channel currents in rat intracardiac neurons.
m4 muscarinic receptor subtype activates an inwardly rectifying potassium conductance in AtT20 cells.
Macaque trophoblast migration is regulated by RANTES.
Macrophage colony-stimulating factor rapidly enhances beta-migrating very low density lipoprotein metabolism in macrophages through activation of a Gi/o protein signaling pathway.
Macrophage depletion prevents leukocyte adhesion and disease induction in experimental melanin-protein induced uveitis.
Macrophages and dendritic cells in IRBP-induced experimental autoimmune uveoretinitis in B10RIII mice.
Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation.
mADP-RTs: versatile virulence factors from bacterial pathogens of plants and mammals.
Magnetic bead isolation of neutrophil plasma membranes and quantification of membrane-associated guanine nucleotide binding proteins.
Magnolol induces cytosolic-free Ca2+ elevation in rat neutrophils primarily via inositol trisphosphate signalling pathway.
Maintained L-type Ca2+ channel activity in excised patches of PTX-treated granule cells of the cerebellum.
Maintenance of biological activity of pertussis toxin radioiodinated while bound to fetuin-agarose.
Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers.
Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells.
Maitotoxin induces phosphoinositide turnover and modulates glutamatergic and muscarinic cholinergic receptor function in cultured cerebellar neurons.
Maitotoxin, a potent, general activator of phosphoinositide breakdown.
Maitotoxin-induced intracellular calcium rise in PC12 cells: involvement of dihydropyridine-sensitive and omega-conotoxin-sensitive calcium channels and phosphoinositide breakdown.
Major pertussis-toxin-sensitive GTP-binding protein of bovine lung. Purification, characterization and production of specific antibodies.
Manganese stimulates stellation of cultured rat cortical astrocytes.
Manipulation of olfactory ensheathing cell signaling mechanisms: effects on their support for neurite regrowth from adult CNS neurons in coculture.
Mannose 6-phosphate/insulin-like growth factor II receptor fails to interact with G-proteins. Analysis of mutant cytoplasmic receptor domains.
Mannosylated self-peptide inhibits the development of experimental autoimmune encephalomyelitis via expansion of nonencephalitogenic T cells.
MAPK activation via 5-hydroxytryptamine 1A receptor is involved in the neuroprotective effects of xaliproden.
MAPkinase: a second site of G-protein regulation of B-cell activation via the antigen receptors.
Mapping of linear B-cell epitopes of the S2 subunit of pertussis toxin.
Mapping of the carboxyl terminus within the tertiary structure of transducin's alpha subunit using the heterobifunctional cross-linking reagent, 125I-N-(3-iodo-4-azidophenylpropionamido-S-(2-thiopyridyl) cysteine.
Maraviroc attenuates the pathogenesis of experimental autoimmune encephalitis.
Marked increase in L-selectin-negative T cells in neonatal pertussis. The lymphocytosis explained?
Marrow engraftment of hematopoietic stem and progenitor cells is independent of Galphai-coupled chemokine receptors.
Masked excitatory action of noradrenaline on rat islet beta-cells via activation of phospholipase C.
Mass spectrometric analysis of multiple pertussis toxins and toxoids.
Mast cell activation by pedicellarial toxin of sea urchin, Toxopneustes pileolus.
Mast cell adenosine induced calcium mobilization via Gi3 and Gq proteins.
Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils.
Mast cell degranulating (MCD) peptide and its optical isomer activate GTP binding protein in rat mast cells.
Mast cell migration to Th2 stimulated airway smooth muscle from asthmatics.
Mast cell tryptase is a mitogen for cultured fibroblasts.
Mastoparan elicits prostaglandin E2 generation and inhibits inositol phosphate accumulation via different mechanisms in rabbit astrocytes.
Mastoparan inhibits beta-adrenoceptor-G(s) signaling by changing the localization of Galpha(s) in lipid rafts.
Mastoparan inhibits phosphoinositide hydrolysis via pertussis toxin-insensitive [corrected] G-protein in human astrocytoma cells.
Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase.
Mastoparan selectively activates phospholipase D2 in cell membranes.
Mastoparan stimulates exocytosis at a Ca(2+)-independent late site in stimulus-secretion coupling. Studies with the RINm5F beta-cell line.
Mastoparan transiently permeabilizes Swiss 3T3 cells and induces c-fos proto-oncogene expression. Role of calcium and G protein activation.
Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulation.
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).
Mastoparan, a wasp venom peptide, identifies two discrete mechanisms for elevating cytosolic calcium and inositol trisphosphates in human polymorphonuclear leukocytes.
Mastoparan, a wasp venom peptide, stimulates release of prolactin from cultured rat anterior pituitary cells.
Mastoparan, a wasp venom, activates platelets via pertussis toxin-sensitive GTP-binding proteins.
Mastoparan, a wasp venom, stimulates insulin release by pancreatic islets through pertussis toxin sensitive GTP-binding protein.
Mastoparan-induced apoptosis of cultured cerebellar granule neurons is initiated by calcium release from intracellular stores.
Mastoparan-induced hormone release from rat pancreatic islets.
Mastoparan-induced phosphatidylcholine hydrolysis by phospholipase D activation in human astrocytoma cells.
Mastoparan-stimulated prolactin secretion in rat pituitary GH3 cells involves activation of Gq/11 proteins.
Maternal allergen immunisation to prevent sensitisation in offspring: Th2-polarising adjuvants are more efficient than a Th1-polarising adjuvant in mice.
Maternal Immunization Earlier in Pregnancy Maximizes Antibody Transfer and Expected Infant Seropositivity Against Pertussis.
Maternal pertussis vaccination and its effects on the immune response of infants aged up to 12 months in the Netherlands: an open-label, parallel, randomised controlled trial.
Maternally derived antibodies against Bordetella pertussis antigens pertussis toxin and filamentous hemagglutinin in preterm and full term newborns.
Matrix metalloproteinase-1 activates a pertussis toxin-sensitive signaling pathway that stimulates the release of matrix metalloproteinase-9.
Matrix metalloproteinase-9 release from human leukocytes.
Maturation and insulin-like immunoreactivity in rat submandibular salivary glands: possible implication of G regulatory proteins.
MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor-kappaB and activating protein-1.
MCP-1 is selectively expressed in the late phase by cytokine-stimulated human neutrophils: TNF-alpha plays a role in maximal MCP-1 mRNA expression.
MCP-1 receptor binding affinity is up-regulated by pre-stimulation with MCP-1 in an actin polymerization-dependent manner.
MCP-1-dependent signaling in CCR2(-/-) aortic smooth muscle cells.
MCP-1-mediated chemotaxis requires activation of non-overlapping signal transduction pathways.
Measurement of agonist efficacy using an alpha2A-adrenoceptor-Gi1alpha fusion protein.
Measurement of free cytosolic calcium in single cells: method and application.
Measures to control an outbreak of pertussis in a neonatal intermediate care nursery after exposure to a healthcare worker.
Measuring immunoglobulin g antibodies to tetanus toxin, diphtheria toxin, and pertussis toxin with single-antigen enzyme-linked immunosorbent assays and a bead-based multiplex assay.
Mechanical hypernociception in experimental autoimmune encephalomyelitis.
Mechanical regulation of native and the recombinant calcium channel.
Mechanical stimulation induces Ca2+i transients and membrane depolarization in cultured endothelial cells. Effects on Ca2+i in co-perfused smooth muscle cells.
Mechanical stimulation of skeletal muscle increases prostaglandin F2 alpha production, cyclooxygenase activity, and cell growth by a pertussis toxin sensitive mechanism.
Mechanical stimulation regulates voltage-gated potassium currents in cardiac microvascular endothelial cells.
Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways.
Mechanical stress and human aortic smooth muscle cell proliferation.
Mechanism and regulation of neutrophil priming by platelet-activating factor.
Mechanism by which pertussis toxin breaks unresponsiveness of delayed-type hypersensitivity to sheep red blood cells in mice.
Mechanism for increase of gastrin release by secretin in Zollinger-Ellison syndrome.
Mechanism for the antitumor and anticachectic effects of n-3 fatty acids.
Mechanism for the gastrokinetic action of domperidone. In vitro studies in guinea pigs.
Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate.
Mechanism of acetylcholine-induced inhibition of Ca current in bullfrog atrial myocytes.
Mechanism of action of ATP on canine pulmonary vagal C fibre nerve terminals.
Mechanism of action of endothelin-1 in the canine pulmonary circulation.
Mechanism of action of gamma-aminobutyric acid on frog melanotrophs.
Mechanism of action of GTP in the induction of Ca2+ release from hepatic microsomes.
Mechanism of action of maternal serum on the interleukin2 receptor expression.
Mechanism of action of peptide YY to inhibit gastric motility.
Mechanism of activation of ERK and H-K-ATPase by isoproterenol in rat cortical collecting duct.
Mechanism of activation of lymphocyte Na+/H+ exchange by concanavalin A. A calcium- and protein kinase C-independent pathway.
Mechanism of adenosine receptor-induced renal vasoconstriction in rats.
Mechanism of alpha 2-adrenoceptor agonist-induced diuresis.
Mechanism of arachidonic acid liberation in platelet-activating factor-stimulated human polymorphonuclear neutrophils.
Mechanism of association of adenylate cyclase toxin with the surface of Bordetella pertussis: a role for toxin-filamentous haemagglutinin interaction.
Mechanism of bradykinin-induced Ca(2+) mobilization in MG63 human osteosarcoma cells.
Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase.
Mechanism of cytokine inhibition of beta-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Impairment of signal transduction.
Mechanism of cytokine-induced modulation of beta-adrenoceptor responsiveness in airway smooth muscle.
Mechanism of D(2) agonist-induced inhibition of GH secretion from human GH-secreting adenoma cells.
Mechanism of down-regulation of alpha-2 adrenergic receptor subtypes.
Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta.
Mechanism of enhanced sensitivity to bradykinin in pertussis toxin-treated fibroblasts: toxin increases bradykinin-stimulated prostaglandin formation.
Mechanism of epinephrine-induced dysrhythmias in rat involves local cholinergic activation.
Mechanism of ET(A)-receptor stimulation-induced increases in intracellular Ca2+ in SK-N-MC cells.
Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells.
Mechanism of galanin-induced contraction of longitudinal smooth muscle of the rat jejunum.
Mechanism of galanin-inhibited insulin release. Occurrence of a pertussis-toxin-sensitive inhibition of adenylate cyclase.
Mechanism of histamine release induced by levofloxacin, a fluoroquinolone antibacterial agent.
Mechanism of impaired beta-adrenoceptor responsiveness in atopic sensitized airway smooth muscle.
Mechanism of induction of prostaglandin E2 production by endothelin 1 in cultured rat mesangial cells.
Mechanism of inhibition of a tumor lipid-mobilizing factor by eicosapentaenoic acid.
Mechanism of inhibition of adenylate cyclase by phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Involvement of a pertussis toxin-sensitive G protein and protein kinase C.
Mechanism of inhibition of calcium channels in rat nucleus tractus solitarius by neurotransmitters.
Mechanism of inhibition of transducin GTPase activity by fluoride and aluminum.
Mechanism of inhibition of transducin guanosine triphosphatase activity by vanadate.
Mechanism of isoproterenol-induced heterologous desensitization of mucin secretion from rat submandibular glands. Regulation of phosphorylation of Gi proteins controls the cell response to the subsequent stimulation.
Mechanism of isoproterenol-induced RGS2 up-regulation in astrocytes.
Mechanism of Li inhibition of vasopressin-sensitive adenylate cyclase in cultured renal epithelial cells.
Mechanism of lipid mobilization associated with cancer cachexia: interaction between the polyunsaturated fatty acid, eicosapentaenoic acid, and inhibitory guanine nucleotide-regulatory protein.
Mechanism of macrophage injury following traumatic hemorrhagic shock: through PTX-sensitive G-protein-mediated signal transduction pathway.
Mechanism of mu-opioid receptor-mediated presynaptic inhibition in the rat hippocampus in vitro.
Mechanism of muscarinic control of the high-threshold calcium current in rabbit sino-atrial node myocytes.
Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: involvement of a GTP-binding protein and role of protein kinase A and protein kinase C.
Mechanism of Na+/Ca2+ exchanger activation by hydrogen peroxide in guinea-pig ventricular myocytes.
Mechanism of neuropeptide Y inhibition of vasopressin action in rat cortical collecting tubule.
Mechanism of neutrophil activation by an unopsonized inflammatory particulate. Monosodium urate crystals induce pertussis toxin-insensitive hydrolysis of phosphatidylinositol 4,5-bisphosphate.
Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist.
Mechanism of noradrenaline-induced heterologous desensitization of adenylate cyclase stimulation in rat heart muscle cells: increase in the level of inhibitory G-protein alpha-subunits.
Mechanism of peptide-induced mast cell degranulation. Translocation and patch-clamp studies.
Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory site.
Mechanism of pertussis toxin B oligomer-mediated protection against Bordetella pertussis respiratory infection.
Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1.
Mechanism of prejunctional muscarinic receptor-mediated inhibition of neurogenic vasodilation in cerebral arteries.
Mechanism of prostaglandin E2-induced arachidonic acid release in osteoblast-like cells: independence from phosphoinositide hydrolysis.
Mechanism of release of Ca2+ from intracellular stores in response to ionomycin in oocytes of the frog Xenopus laevis.
Mechanism of retinoic acid induced attenuation of PTH action in UMR 106-01 cells.
Mechanism of rhinovirus-induced changes in airway smooth muscle responsiveness.
Mechanism of sodium transport inhibition by epidermal growth factor in cortical collecting ducts.
Mechanism of stress-induced attenuation of the testicular response to gonadotropin: possible involvement of testicular opioids, a pertussis toxin-sensitive G-protein, and phosphodiesterase.
Mechanism of synaptic inhibition by noradrenaline acting at alpha 2-adrenoceptors.
Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat.
Mechanism of the effects of acetylcholine on the contractile properties and Ca2+ transients in ferret ventricular muscles.
Mechanism of the mitogenic effect of fluoride on osteoblast-like cells: evidences for a G protein-dependent tyrosine phosphorylation process.
Mechanism of the prolactin rebound after dopamine withdrawal in rat pituitary cells.
Mechanism of thrombin-induced vasodilation in human coronary arterioles.
Mechanism of toxic action of fluoride in dental fluorosis: whether trimeric G proteins participate in the disturbance of intracellular transport of secretory ameloblast exposed to fluoride.
Mechanism underlying histamine-induced desensitization of amylase secretion in rat parotid glands.
Mechanism(s) of activation of secretory phospholipase A(2)s in mouse keratinocytes.
Mechanisms and modulation of pituitary adenylate cyclase-activating protein-induced calcium mobilization in human neutrophils.
Mechanisms contributing to fluid-flow-induced Ca2+ mobilization in articular chondrocytes.
Mechanisms for direct inhibition of canine gastric parietal cells by somatostatin.
Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.
Mechanisms for lipoxin A4-induced neutrophil-dependent cytotoxicity for human endothelial cells.
Mechanisms for muscarinic inhibition of somatostatin release from canine fundic D cells.
Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells.
Mechanisms for the inhibition of amiloride-sensitive Na+ absorption by extracellular nucleotides in mouse trachea.
Mechanisms for the stimulatory and inhibitory effects of carbamoylcholine on canine gastric D-cells.
Mechanisms for vagal modulation of ventricular repolarization and of coronary occlusion-induced lethal arrhythmias in cats.
Mechanisms in bradykinin stimulated arachidonate release and synthesis of prostaglandin and platelet activating factor.
Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.
Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones.
Mechanisms involved in activation of human eosinophil exocytosis by substance P: an in vitro model of sensory neuroimmunomodulation.
Mechanisms involved in morphine-induced activation of synaptosomal Na+,K+-ATPase.
Mechanisms involved in stimulation of human immunodeficiency virus type 1 replication by aminooxypentane RANTES.
Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice.
Mechanisms involved in the interaction of dopamine with angiotensin II on aldosterone secretion in isolated and cultured rat adrenal glomerulosa cells.
Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord.
Mechanisms leading to adenosine-stimulated proliferation of microvascular endothelial cells.
Mechanisms linking adenosine A1 receptors and extracellular signal-regulated kinase 1/2 activation in human trabecular meshwork cells.
Mechanisms mediating cholinergic antral circular smooth muscle contraction in rats.
Mechanisms of action of angiotensin II on mammalian sperm function.
Mechanisms of action of antisecretory drugs. Studies on isolated canine fundic mucosal cells.
Mechanisms of action of cyclosporin A on islet alpha- and beta-cells. Effects on cAMP- and calcium-dependent pathways.
Mechanisms of action of long-acting analogs of somatostatin.
Mechanisms of adenosine 5'-triphosphate-induced dopamine release in the rat nucleus accumbens in vivo.
Mechanisms of alpha,beta-methylene atp-induced inhibition in rat ileal smooth muscle: involvement of intracellular Ca2+ stores in purinergic inhibition.
Mechanisms of ANG II-induced mitogenic responses: role of 12-lipoxygenase and biphasic MAP kinase.
Mechanisms of biomaterial-induced superoxide release by neutrophils.
Mechanisms of Bordetella pathogenesis.
Mechanisms of bradykinin-induced glucagon release in clonal alpha-cells In-R1-G9: involvement of Ca(2+)-dependent and -independent pathways.
Mechanisms of bradykinin-induced insulin secretion in clonal beta cell line RINm5F.
Mechanisms of bradykinin-mediated Ca(2+) signalling in canine cultured corneal epithelial cells.
Mechanisms of C5a and C3a complement fragment-induced [Ca2+]i signaling in mouse microglia.
Mechanisms of calcium mobilization and phosphoinositide hydrolysis in human bronchial smooth muscle cells by endothelin 1.
Mechanisms of cell transformation in the embryonic heart.
Mechanisms of cocaine-induced sensitization.
Mechanisms of coronary microvascular dilation induced by the activation of pertussis toxin-sensitive G proteins are vessel-size dependent. Heterogeneous involvement of nitric oxide pathway and ATP-sensitive K+ channels.
Mechanisms of desensitization to parathyroid hormone in human osteoblast-like SaOS-2 cells.
Mechanisms of diethylstilbestrol-induced relaxation in rat aorta smooth muscle.
Mechanisms of glucagon-induced homologous and heterologous desensitization of adenylate cyclase in membranes and whole Sertoli cells of the rat.
Mechanisms of glutamate induced swelling in astroglial cells.
Mechanisms of human eosinophil activation by complement protein C5a and platelet-activating factor: similar functional responses are accompanied by different morphologic alterations.
Mechanisms of IL-8-induced Ca2+ signaling in human neutrophil granulocytes.
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction.
Mechanisms of impaired beta-adrenoceptor-induced airway relaxation by interleukin-1beta in vivo in the rat.
Mechanisms of inhibition of insulin release.
Mechanisms of interaction between human skin fibroblasts and elastin: differences between elastin fibres and derived peptides.
Mechanisms of ischemic preconditioning in rat hearts. Involvement of alpha 1B-adrenoceptors, pertussis toxin-sensitive G proteins, and protein kinase C.
Mechanisms of kringle fragment of urokinase-induced vascular smooth muscle cell migration.
Mechanisms of L-NG nitroarginine/indomethacin-resistant relaxation in bovine and porcine coronary arteries.
Mechanisms of leptin secretion from white adipocytes.
Mechanisms of lithium-vasopressin interaction in rabbit cortical collecting tubule.
Mechanisms of mastoparan-stimulated surfactant secretion from isolated pulmonary alveolar type 2 cells.
Mechanisms of mitogen-activated protein kinase activation by nicotine in small-cell lung carcinoma cells.
Mechanisms of NE-induced reduction of Ca current in single smooth muscle cells from guinea pig vas deferens.
Mechanisms of nonopsonic phagocytosis of Pseudomonas aeruginosa.
Mechanisms of norepinephrine mediated corticotropin-releasing factor-41 release from cultured fetal hypothalamic cells.
Mechanisms of opioid actions on neurons of the locus coeruleus.
Mechanisms of opioid delta (delta) and kappa ( kappa) receptors' cardioprotection in ischaemic preconditioning in a rat model of myocardial infarction.
Mechanisms of P2 receptor-evoked DNA synthesis in thyroid FRTL-5 cells.
Mechanisms of pertussis toxin inhibition of lymphocyte-HEV interactions. I. Analysis of lymphocyte homing receptor-mediated binding mechanisms.
Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of CD14 and urokinase receptor.
Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87).
Mechanisms of phospholipase C activation by the vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating polypeptide type 2 receptor.
Mechanisms of platelet activation: thromboxane A2 as an amplifying signal for other agonists.
Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids.
Mechanisms of PTH-induced rise in cytosolic calcium in adult rat hepatocytes.
Mechanisms of rapid desensitization to arginine vasopressin in vascular smooth muscle cells.
Mechanisms of recovery from mechanical injury of cultured rat hepatocytes.
Mechanisms of serotonin-induced Ca2+ responses in mesangial cells.
Mechanisms of signal transduction for adenosine and ATP in pulmonary vascular bed.
Mechanisms of somatostatin action in RINm5F cells in culture: preliminary evidence for possible altered G protein function.
Mechanisms of the antilipolytic response of human adipocytes to tyramine, a trace amine present in food.
Mechanisms of the lysophosphatidic acid-induced increase in [Ca(2+)](i) in skeletal muscle cells.
Mechanisms of the palmitoylcarnitine-induced response in vascular endothelial cells.
Mechanisms of the thapsigargin-induced Ca(2+) entry in in situ endothelial cells of the porcine aortic valve and the endothelium-dependent relaxation in the porcine coronary artery.
Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells.
Mechanisms of vasorelaxation induced by oleoylethanolamide in the rat small mesenteric artery.
Mechanisms regulating oxytocin receptor coupling to phospholipase C in rat and human myometrium.
Mechanisms underlying attenuated contractile response of aortic rings to noradrenaline in fructose-fed mice.
Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5.
Mechanisms underlying intracellular signal transduction of the slow IPSP in submucous neurones of the guinea-pig caecum.
Mechanisms underlying presynaptic inhibition through alpha 2-adrenoceptors in guinea-pig submucosal neurones.
Mechanisms Underlying the Inhibition of Soman on NMDA-stimulated [(3)H]Norepinephrine Release from Rat Cortical Slices, Role of Phospholipase C and Protein Kinase C.
Mechanisms underlying the riluzole inhibition of glutamate release from rat cerebral cortex nerve terminals (synaptosomes).
Mechanistic insight into pertussis toxin and lectin signaling using T cells engineered to express a CD8?/CD3? chimeric receptor.
Mechanistic insights into ?-opioid-induced cardioprotection: Involvement of caveolin translocation to the mitochondria.
Mechanistic investigation of N,N-diethyl-4-(phenyl-piperidin-4-ylidenemethyl)-benzamide-induced insulin depletion in the rat and RINm5F cells.
Mediation by G proteins of signals that cause collapse of growth cones.
Mediation by protein kinases C and A of Go-linked slow responses of enteric neurons to 5-HT.
Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3.
Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2.
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
Meibomian gland dysfunction is suppressed via selective inhibition of immune responses by topical LFA-1/ICAM antagonism with lifitegrast in the allergic eye disease (AED) model.
Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte.
Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus.
Melanin-concentrating hormone depresses L-, N-, and P/Q-type voltage-dependent calcium channels in rat lateral hypothalamic neurons.
Melanin-concentrating hormone reduces somatolactin release from cultured goldfish pituitary cells.
Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells.
Melanocortin type 4 receptor-mediated inhibition of A-type K+ current enhances sensory neuronal excitability and mechanical pain sensitivity in rats.
Melanocortin-3 receptor activates MAP kinase via PI3 kinase.
Melanoma growth stimulatory activity enhances the phosphorylation of the class II interleukin-8 receptor in non-hematopoietic cells.
Melanostatin (NPY) inhibited electrical activity in frog melanotrophs through modulation of K+, Na+ and Ca2+ currents.
Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn.
Melatonin agonists induce phosphoinositide hydrolysis in Xenopus laevis melanophores.
Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells.
Melatonin directly constricts rat cerebral arteries through modulation of potassium channels.
Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade.
Melatonin enhances leptin expression by rat adipocytes in the presence of insulin.
Melatonin generates an outward potassium current in rat suprachiasmatic nucleus neurones in vitro independent of their circadian rhythm.
Melatonin increases proliferation of cultured neural stem cells obtained from adult mouse subventricular zone.
Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events.
Melatonin inhibition of nicotine-stimulated dopamine release in PC12 cells.
Melatonin inhibits fatty acid transport in inguinal fat pads of hepatoma 7288CTC-bearing and normal Buffalo rats via receptor-mediated signal transduction.
Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells.
Melatonin inhibits insulin secretion in rat insulinoma ?-cells (INS-1) heterologously expressing the human melatonin receptor isoform MT2.
Melatonin modulates diacylglycerol and arachidonic acid metabolism in the anterior pituitary of immature rats.
Melatonin modulates intercellular communication among cultured chick astrocytes.
Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins.
Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
Melatonin prevents apoptosis and enhances HSP27 mRNA expression induced by heat shock in HL-60 cells: possible involvement of the MT2 receptor.
Melatonin promotes osteoblast differentiation and bone formation.
Melatonin receptor agonist ramelteon activates the extracellular signal-regulated kinase 1/2 in mouse cerebellar granule cells.
Melatonin Receptor MT1 Signals to Extracellular Signal-Regulated Kinase 1 and 2 via Gi and Gs Dually Coupled Pathways in HEK-293 Cells.
Melatonin receptor potentiation of cyclic AMP and the cystic fibrosis transmembrane conductance regulator ion channel.
Melatonin receptor signaling in pregnant and nonpregnant rat uterine myocytes as probed by large conductance Ca2+-activated K+ channel activity.
Melatonin receptors activate heteromeric G-protein coupled Kir3 channels.
Melatonin receptors are present in adult rat Leydig cells and are coupled through a pertussis toxin-sensitive G-protein.
Melatonin receptors in benign prostate epithelial cells: evidence for the involvement of cholera and pertussis toxins-sensitive G proteins in their signal transduction pathways.
Melatonin receptors in PC3 human prostate tumor cells.
Melatonin receptors in the chicken kidney are up-regulated by pinealectomy and linked to adenylate cyclase.
Melatonin receptors in the spinal cord.
Melatonin signal transduction and mechanism of action in the central nervous system: using the rabbit cortex as a model.
Melatonin signal transduction in hamster brain: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein.
Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice.
Melatonin-induced organelle movement in melanophores is coupled to tyrosine phosphorylation of a high molecular weight protein.
Melatonin-induced suppression of PC12 cell growth is mediated by its Gi coupled transmembrane receptors.
Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells.
Melatonin-mediated inhibition of Purkinje neuron P-type Ca(2+) channels in vitro induces neuronal hyperexcitability through the phosphatidylinositol 3-kinase-dependent protein kinase C delta pathway.
Membrane anchored synthetic peptides as a tool for structure-function analysis of pertussis toxin and its target proteins.
Membrane androgen receptor characteristics of human ZIP9 (SLC39A) zinc transporter in prostate cancer cells: Androgen-specific activation and involvement of an inhibitory G protein in zinc and MAP kinase signaling.
Membrane electrical activity elicits inositol 1,4,5-trisphosphate-dependent slow Ca2+ signals through a Gbetagamma/phosphatidylinositol 3-kinase gamma pathway in skeletal myotubes.
Membrane gangliosides modulate interleukin-2-stimulated T-lymphocyte proliferation.
Membrane localization of the S1 subunit of pertussis toxin in Bordetella pertussis and implications for pertussis toxin secretion.
Membrane signaling and progesterone in female and male osteoblasts. II. Direct involvement of G alpha q/11 coupled to PLC-beta 1 and PLC-beta 3.
Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation.
Membrane-associated 41-kDa GTP-binding protein in collagen-induced platelet activation.
Membrane-bound form of ADP-ribosyl cyclase in rat cortical astrocytes in culture.
Membrane-delimited G protein-mediated coupling between V1a vasopressin receptor and dihydropyridine binding sites in rat glomerulosa cells.
Membrane-impermeable estrogen is involved in regulation of calbindin-D9k expression via non-genomic pathways in a rat pituitary cell line, GH3 cells.
MENTHOL INHIBITS 5-HT3 RECEPTOR-MEDIATED CURRENTS.
Mepyramine but not cimetidine or clobenpropit blocks pertussis toxin-induced histamine sensitization in rats.
Messengers mediating long-term desensitization in cerebellar Purkinje cells.
Metabolic activation of A549 human airway epithelial cells by organic dust: a study based on microphysiometry.
Metabolic stimulation of mouse spleen lymphocytes by low doses of delta9-tetrahydrocannabinol.
Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT-9K/129G.
Metabolism and biologic effects of 5-oxoeicosanoids on human neutrophils.
Metabolite-Induced Protein Expression Guided by Metabolomics and Systems Biology.
Metabotropic ?-aminobutyric acid (GABA(B) ) receptors modulate feeding behavior in the calcisponge Leucandra aspera.
Metabotropic ?-aminobutyric acid (GABA(B)) receptors modulate feeding behavior in the calcisponge Leucandra aspera.
Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes.
Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes.
Metabotropic glutamate receptor activation modulates kainate and serotonin calcium response in astrocytes.
Metabotropic glutamate receptor agonist-induced hyperpolarizations in rat basolateral amygdala neurons: receptor characterization and ion channels.
Metabotropic glutamate receptor agonists potentiate cyclic AMP formation induced by forskolin or beta-adrenergic receptor activation in cerebral cortical astrocytes in culture.
Metabotropic glutamate receptor analogues inhibit p[NH]ppG-stimulated phospholipase C activity in bovine brain coated vesicles: involvement of a pertussis toxin-sensitive G-protein.
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Metabotropic glutamate receptor modulation of glutamate responses in the suprachiasmatic nucleus.
Metabotropic glutamate receptor modulation of synaptic transmission in corticostriatal co-cultures: role of calcium influx.
Metabotropic glutamate receptor modulation of voltage-gated Ca2+ channels involves multiple receptor subtypes in cortical neurons.
Metabotropic glutamate receptor subtype 1A activates adenylate cyclase when expressed in baby hamster kidney cells.
Metabotropic glutamate receptor type 4 is involved in autoinhibitory cascade for glucagon secretion by alpha-cells of islet of Langerhans.
Metabotropic glutamate receptors activate G-protein-coupled inwardly rectifying potassium channels in Xenopus oocytes.
Metabotropic glutamate receptors modulate [(3)H]acetylcholine release from cultured amacrine-like neurons.
Metabotropic glutamate receptors negatively regulate melatonin synthesis in rat pinealocytes.
Metabotropic glutamate response in acutely dissociated hippocampal CA1 pyramidal neurones of the rat.
Metabotropic neurosteroid/sigma-receptor involved in stimulation of nociceptor endings of mice.
Metabotropic P2Y1 receptors inhibit P2X3 receptor-channels in rat dorsal root ganglion neurons.
Metabotropic signal transduction for bradykinin in submucosal neurons of guinea pig small intestine.
Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system.
Metallothionein mediates leukocyte chemotaxis.
Metronidazole Attenuates the Intensity of Inflammation in Experimental Autoimmune Uveitis.
Mg(++)-induced endothelial cell migration: substratum selectivity and receptor-involvement.
mGluR7 inhibits glutamate release through a PKC-independent decrease in the activity of P/Q-type Ca2+ channels and by diminishing cAMP in hippocampal nerve terminals.
mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons.
MHC-restricted recognition of immunogenic T cell epitopes of pertussis toxin reveals determinants in man distinct from the ADP-ribosylase active site.
Mice lacking the IFN-gamma receptor or fyn develop severe experimental autoimmune uveoretinitis characterized by different immune responses.
Microbial products trigger autoimmune ocular inflammation.
Microbiological and serological diagnosis of pertussis.
Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease.
Microfilament assembly is required for antigen-receptor-mediated activation of human B lymphocytes.
Microinjection of the alpha-subunit of the G protein Go2, but not Go1, reduces a voltage-sensitive calcium current.
Microsomal and cytosolic fractions of guinea pig hepatocytes contain 100-kilodalton GTP-binding proteins reactive with antisera against alpha subunits of stimulatory and inhibitory heterotrimeric GTP-binding proteins.
Microsomal prostaglandin E synthase-1 contributes to ischaemic excitotoxicity through prostaglandin E2 EP3 receptors.
Microtubule-dependent regulation of alpha(2B) adrenergic receptors in polarized MDCKII cells requires the third intracellular loop but not G protein coupling.
Microtubule-disruption-induced and chemotactic-peptide-induced migration of human neutrophils: implications for differential sets of signalling pathways.
Midkine induces histamine release from mast cells and the immediate cutaneous response.
Midkine, a retinoic acid-inducible heparin-binding cytokine, is a novel regulator of intracellular calcium in human neutrophils.
Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120.
Migration of intestinal intraepithelial lymphocytes into a polarized epithelial monolayer.
Mimicking of discontinuous epitopes by phage-displayed peptides, II. Selection of clones recognized by a protective monoclonal antibody against the Bordetella pertussis toxin from phage peptide libraries.
Mimicry of a G protein mutation by pertussis toxin expression in transgenic Caenorhabditis elegans.
Mini-dystrophin Expression Down-regulates Overactivation of G Protein-mediated IP3 Signaling Pathway in Dystrophin-deficient Muscle Cells.
Miniglucagon (glucagon 19-29), a potent and efficient inhibitor of secretagogue-induced insulin release through a Ca2+ pathway.
Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate.
Mitigation of beta 1- and/or beta 2-adrenoceptor function in human heart failure.
Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1.
Mitocryptide-2: purification, identification, and characterization of a novel cryptide that activates neutrophils.
Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.
Mitogen-activated protein kinase cascade is involved in endothelin-1-induced rat puerperal uterine contraction.
Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway.
Mitogen-induced activation of Na+/H+ exchange in vascular smooth muscle cells involves janus kinase 2 and Ca2+/calmodulin.
Mitogen-induced tyrosine phosphorylation of 41 kDa and 43 kDa proteins. Potential role in integrating multiple mitogenic signalling pathways.
Mitogenic action of lysophosphatidic acid in proximal tubular epithelial cells obtained from voided human urine.
Mitogenic activity of endothelin on human cultured prostatic smooth muscle cells.
Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway.
Mitogenic effect of serotonin on vascular endothelial cells.
Mitogenic effects of fibroblast growth factors in cultured fibroblasts. Interaction with the G-protein-mediated signaling pathways.
Mitogenic effects of pertussis toxin-sensitive G-protein alpha subunits: the mitogenic action of alpha i2 in NIH 3T3 cells is mimicked by alpha i1, but not alpha i3.
Mitogenic functions of endocrine gland-derived vascular endothelial growth factor and Bombina variegata 8 on steroidogenic adrenocortical cells.
Mitogenic signaling mechanisms of human cementum-derived growth factors.
Mitogenic signaling pathways of growth factors can be distinguished by the involvement of pertussis toxin-sensitive guanosine triphosphate-binding protein and of protein kinase C.
Mitogenic signalling by delta opioid receptors expressed in rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase.
Mitoxantrone induces nonimmunological histamine release from rat mast cells.
Mivazerol prevents the tachycardia caused by emergence from halothane anesthesia partly through activation of spinal alpha 2-adrenoceptors.
Mixture model analysis for establishing a diagnostic cut-off point for pertussis antibody levels.
MLCK and PKC Involvements via Gi and Rho A Protein in Contraction by the Electrical Field Stimulation in Feline Esophageal Smooth Muscle.
Mobilisation of intracellular calcium by P2Y2 receptors in cultured, non-transformed bovine ciliary epithelial cells.
Mobilization of intracellular Ca2+ and stimulation of cyclic AMP production by kappa opioid receptors expressed in Xenopus oocytes.
Mobilization of intracellular Ca2+ and suppression of inward currents in a neuronal hybrid cell line triggered by bradykinin.
Mobilization of intracellular calcium in cultured vascular smooth muscle cells by uridine triphosphate and the calcium ionophore A23187.
Mode of inhibition of renin release by angiotensin II.
Modeling rates of infection with transient maternal antibodies and waning active immunity: application to Bordetella pertussis in Sweden.
Moderate hypothermia attenuates ?(1)-adrenoceptor-mediated contraction in isolated rat aorta: the role of the endothelium.
Modification by pertussis toxin of the responses of bovine anterior pituitary cells to acetylcholine and dopamine: effects on hormone secretion and 86Rb efflux.
Modification of biological responses to interleukin-1 by agents that perturb signal transduction pathways.
Modification of cholinergic-mediated cellular transmembrane signals by the interaction of human chagasic IgG with cardiac muscarinic receptors.
Modification of chromaffin cells with pertussis toxin or N-ethylmaleimide lowers cytoskeletal F-actin and enhances Ca(2+)-dependent secretion.
Modification of cysteine residues within G(o) and other neuronal proteins by exposure to nitric oxide.
Modification of morphine-induced analgesia and toxicity by pertussis toxin.
Modification of morphine-induced locomotor activity by pertussis toxin: biochemical and behavioral studies in mice.
Modification of opioid agonist binding by pertussis toxin.
Modification of plasma membrane protein cysteine residues by ADP-ribose in vivo.
Modification of serotonin responses in rat dorsolateral septal nucleus neurons by acute and chronic cocaine.
Modification of the amounts of G proteins and of the activity of adenylyl cyclase in human benign thyroid tumours.
Modification of the function of pertussis toxin substrate GTP-binding protein by cholera toxin-catalyzed ADP-ribosylation.
Modifications of the catalytic and binding subunits of pertussis toxin by formaldehyde: effects on toxicity and immunogenicity.
Modified binding assay for improved sensitivity and specificity in the detection of residual pertussis toxin in vaccine preparations.
Modulation by 1,25(OH)2-vitamin D3 of the adenylyl cyclase/cyclic AMP pathway in rat and chick myoblasts.
Modulation by angiotensin II of isoproterenol-induced cAMP production in preglomerular microvascular smooth muscle cells from normotensive and genetically hypertensive rats.
Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.
Modulation by neurotransmitters of catecholamine secretion from sympathetic ganglion neurons detected by amperometry.
Modulation by pertussis toxin of salbutamol- and arecoline-induced effects in the isolated heart and aorta of the rat.
Modulation by protein kinase C of the enhanced responsiveness to tachykinins in ovalbumin-sensitized guinea pig alveolar macrophages.
Modulation by sigma ligands of N-methyl-D-aspartate-induced [3H]noradrenaline release in the rat hippocampus: G-protein dependency.
Modulation by somatostatin of glutamate sensitivity during development of mouse hypothalamic neurons in vitro.
Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein.
Modulation of ?-opioid receptor signaling by RGS19 in SH-SY5Y cells.
Modulation of a delayed-rectifier K+ current by angiotensin II in rat sympathetic neurons.
Modulation of adenylate cyclase activity of mouse spinal cord-ganglion explants by opioids, serotonin and pertussis toxin.
Modulation of adenylate cyclase in human keratinocytes by protein kinase C.
Modulation of adenylyl cyclase by FPP and adenosine involves stimulatory and inhibitory adenosine receptors and g proteins.
Modulation of agonist binding to recombinant human alpha2-adrenoceptors by sodium ions.
Modulation of ATP-sensitive K+ channels in rabbit ventricular myocytes by adenosine A1 receptor activation.
Modulation of basal L-type Ca2+ current by adenosine in ferret isolated right ventricular myocytes.
Modulation of big K+ channel activity by ryanodine receptors and L-type Ca2+ channels in neurons.
Modulation of bombesin-induced phosphatidylinositol hydrolysis in a small-cell lung-cancer cell line.
Modulation of Bordetella pertussis infection with monoclonal antibodies to pertussis toxin.
Modulation of bradykinin-induced inositol trisphosphate release in a novel neuroblastoma x dorsal root ganglion sensory neuron cell line (F-11).
Modulation of brain Na+ channels by a G-protein-coupled pathway.
Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a.
Modulation of Ca(2+)-channel currents by protein kinase C in adult rat sympathetic neurons.
Modulation of Ca2+ channel currents of acutely dissociated rat periaqueductal grey neurons.
Modulation of Ca2+ channels by heterologously expressed wild-type and mutant human micro-opioid receptors (hMORs) containing the A118G single-nucleotide polymorphism.
Modulation of Ca2+ channels by intracellular Mg2+ ions and GTP in frog ventricular myocytes.
Modulation of Ca2+ channels by opioid receptor-like 1 receptors natively expressed in rat stellate ganglion neurons innervating cardiac muscle.
Modulation of Ca2+ channels by PTX-sensitive G-proteins is blocked by N-ethylmaleimide in rat sympathetic neurons.
Modulation of Ca2+ currents by various G protein-coupled receptors in sympathetic neurons of male rat pelvic ganglia.
Modulation of calcium channels by metabotropic glutamate receptors in cerebellar granule cells.
Modulation of calcium currents by a metabotropic glutamate receptor involves fast and slow kinetic components in cultured hippocampal neurons.
Modulation of calcium signalling and proliferation in monoblastoid U-937 cells.
Modulation of cannabinoid-induced antinociception after intracerebroventricular versus intrathecal administration to mice: possible mechanisms for interaction with morphine.
Modulation of cardiac cell Ca2+ currents by PAF.
Modulation of cardiac cyclic AMP metabolism by adenosine receptor agonists and antagonists.
Modulation of cardiac L-type Ca2+ channels by GTP gamma S in response to isoprenaline, forskolin and photoreleased nucleotides.
Modulation of cardiac sodium channels by cAMP receptors on the myocyte surface.
Modulation of carrier-induced epitopic suppression by Bordetella pertussis components and muramyl peptide.
Modulation of CD4 Th cell differentiation by ganglioside GD1a in vitro.
Modulation of Central Control of Hypotensive Effects by Neuropeptide Y is Mediated through RSK Induced Activation of Endothelial Nitric Oxide Synthase.
Modulation of cyclic AMP accumulation in glial cells by exogenous phospholipase C.
Modulation of dihydropyridine-sensitive calcium channels: a role for G proteins.
Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptor.
Modulation of excitatory synaptic transmission by low concentrations of glutamate in cultured rat hippocampal neurons.
Modulation of gastric emptying and gastrointestinal transit in rats through intestinal cannabinoid CB(1) receptors.
Modulation of GH4 cell cycle via A1 adenosine receptors.
Modulation of growth cone calcium current is mediated by a PTX-sensitive G protein.
Modulation of high-voltage activated Ca2+ channels in the rat periaqueductal gray neurons by mu-type opioid agonist.
Modulation of hippocampal excitability via the hydroxycarboxylic acid receptor 1.
Modulation of hypothalamic norepinephrine release by atrial natriuretic peptide: involvement of cyclic GMP.
Modulation of IL-1-induced collagenase production in articular chondrocytes by pertussis toxin.
Modulation of interleukin 1 production by endotoxin, pertussis toxin, and indomethacin.
Modulation of intracellular calcium transients and dopamine release by neuropeptide Y in PC-12 cells.
Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons.
Modulation of islet G-proteins, alpha-glucosidehydrolase inhibition and insulin release stimulated by various secretagogues.
Modulation of keratin intermediate filament distribution in vivo by induced changes in cyclic AMP-dependent phosphorylation.
Modulation of L-type Ca current by denopamine, a nonparenteral partial beta 1 stimulant, in rabbit ventricular cells.
Modulation of L-type Ca2+ current by extracellular ATP in ferret isolated right ventricular myocytes.
Modulation of leukotriene B4 and platelet-activating factor binding to neutrophils.
Modulation of leukotriene generation by pertussis toxin.
Modulation of ligand responses by coupling of alpha(2A)-adrenoceptors to diverse G(alpha)-proteins.
Modulation of meiotic arrest in mouse oocytes by guanyl nucleotides and modifiers of G-proteins.
Modulation of melatonin receptors and G-protein function by microtubules.
Modulation of muscarinic receptor-mediated adenylate cyclase and phospholipase C responses in rat retina.
Modulation of myocardial contractility by lysophosphatidic acid (LPA).
Modulation of N-type Ca2+ currents by A1-adenosine receptor activation in male rat pelvic ganglion neurons.
Modulation of N-type calcium currents by presynaptic imidazoline receptor activation in rat superior cervical ganglion neurons.
Modulation of N-type Ca²? currents by moxonidine via imidazoline I? receptor activation in rat superior cervical ganglion neurons.
Modulation of neuronal T-type calcium channel currents by photoactivation of intracellular guanosine 5'-O(3-thio) triphosphate.
Modulation of neuropeptide Y expression in rat brain neuronal cultures.
Modulation of neurotransmitter release via histamine H3 heteroreceptors.
Modulation of neutrophil apoptosis by beta-amyloid proteins.
Modulation of neutrophil migration by captopril.
Modulation of NO and endothelin by chronic increases in blood flow in canine femoral arteries.
Modulation of norepinephrine release by galanin in rat medulla oblongata.
Modulation of octopamine-mediated production of cyclic AMP by phorbol-ester-sensitive protein kinase C in an insect cell line.
Modulation of Pertussis and Adenylate Cyclase Toxins by Sigma Factor RpoE in Bordetella pertussis.
Modulation of phospholipase C pathway and level of Gq alpha/G11 alpha in rat myometrium during gestation.
Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1.
Modulation of prolactin-stimulated Nb2 lymphoma cell mitogenesis by cholera toxin and pertussis toxin.
Modulation of prostaglandin E2 synthesis in rat skeletal muscle.
Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid.
Modulation of protein kinase C by adenosine: involvement of adenosine A1 receptor-pertussis toxin sensitive nucleotide binding protein system.
Modulation of protein phosphatase 2a by adenosine A1 receptors in cardiomyocytes: role for p38 MAPK.
Modulation of respiratory rhythm in vitro: role of Gi/o protein-mediated mechanisms.
Modulation of responsiveness of the adenylate cyclase system in avian chondroprogenitor cells by pertussis toxin, PTH, and PGE2.
Modulation of responsiveness to cAMP stimulating agonists by phorbol ester in fetal rat osteoblasts.
Modulation of sensory neuron potassium conductances by anandamide indicates roles for metabolites.
Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons.
Modulation of sperm acrosomal exocytosis by guanyl nucleotides and G-protein-modifier agents.
Modulation of the accumulation of inositol phosphates and the mobilization of calcium in aortic myocytes.
Modulation of the beta-adrenergic receptor-coupled adenylate cyclase by chemical inducers of differentiation: effects on beta receptors and the inhibitory regulatory protein Gi.
Modulation of the cardiac pacemaker of Drosophila: cellular mechanisms.
Modulation of the delayed rectifier K+ current in neurons by an angiotensin II type 2 receptor fragment.
Modulation of the infant immune responses by the first pertussis vaccine administrations.
Modulation of the muscarinic K+ channel by P2-purinoceptors in guinea-pig atrial myocytes.
Modulation of the neuronal nicotinic acetylcholine receptor-channel by the nootropic drug nefiracetam.
Modulation of the pacemaker current If by beta-adrenoceptor subtypes in ventricular myocytes isolated from hypertensive and normotensive rats.
Modulation of the priming effects of platelet-activating factor on the release of interleukin-1 from lipopolysaccharide-stimulated rat spleen macrophages.
Modulation of the voltage-dependent sodium channel by agents affecting G-proteins: a study in Xenopus oocytes injected with brain RNA.
Modulation of thymidine incorporation by kappa-opioid ligands in rat spinal cord-dorsal root ganglion co-cultures.
Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells.
Modulation of tryptase secretion from human colon mast cells by histamine.
Modulation of tumor necrosis factor-alpha cytotoxicity in L929 cells by bacterial toxins, hydrocortisone and inhibitors of arachidonic acid metabolism.
Modulation of vasopressin antidiuretic action by renal alpha 2-adrenoceptors.
Modulation of vertebrate neuronal calcium channels by transmitters.
Modulation of voltage-activated Ca currents by pain-inducing agents in a dorsal root ganglion neuronal line, F-11.
Modulation of voltage-dependent Ca2+ conductance by changing Cl- concentration in rat lactotrophs.
Modulation of voltage-dependent calcium currents by serotonin in acutely isolated rat amygdala neurons.
Modulation of voltage-gated calcium channels by orphanin FQ in freshly dissociated hippocampal neurons.
Modulation of [3H]acetylcholine release from cultured amacrine-like neurons by adenosine A1 receptors.
Modulation of [3H]dihydropyridine binding by activation of protein kinase C in vascular smooth muscle.
Modulation of [3H]dopamine release by neuropeptide Y in rat striatal slices.
Modulatory role of adenosine receptors in insect motor nerve terminals.
Moesin regulates neutrophil rolling velocity in vivo.
Molecular analysis of CCR-3 events in eosinophilic cells.
Molecular and cellular analyses of melatonin receptor-mediated cAMP signaling in rat corpus epididymis.
Molecular and pharmacological characterization of zebrafish 'contractile' and 'inhibitory' prostanoid receptors.
Molecular aspects of Bordetella pertussis pathogenesis.
Molecular basis for cellular effects of naturally occurring polyamines.
Molecular basis for somatostatin action: inhibition of c-fos expression and AP-1 binding.
Molecular basis for the insulinomimetic effects of C-peptide.
Molecular characterization of a G protein alpha-subunit-encoding gene from Mucor circinelloides.
Molecular characterization of an operon required for pertussis toxin secretion.
Molecular characterization of the in vitro activation of pertussis toxin by ATP.
Molecular characterization of two Bordetella bronchiseptica strains isolated from children with coughs.
Molecular cloning and analysis of P. 69, a vir-controlled protein from Bordetella pertussis.
Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid.
Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis.
Molecular cloning and characterization of RGA1 encoding a G protein alpha subunit from rice (Oryza sativa L. IR-36).
Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells.
Molecular cloning and expression of two melanin-concentrating hormone receptors in goldfish.
Molecular cloning and functional characterization of a rat somatostatin sst2(b) receptor splice variant.
Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein.
Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector.
Molecular cloning of heterotrimeric G-protein alpha-subunits in chicken pineal gland.
Molecular cloning of pertussis toxin genes.
Molecular cloning of prostaglandin EP3 receptors from canine sensory ganglia and their facilitatory action on bradykinin-induced mobilization of intracellular calcium.
Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis.
Molecular control of cardiac sodium homeostasis in health and disease.
Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock.
Molecular effects of proinsulin C-peptide.
Molecular epidemiology of Bordetella pertussis and analysis of vaccine antigen genes from clinical isolates from Shenzhen, China.
Molecular epidemiology of Bordetella pertussis in Cambodia determined by direct genotyping of clinical specimens.
Molecular epidemiology of Bordetella pertussis in the Philippines in 2012-2014.
Molecular Epidemiology of Bordetella pertussis.
Molecular mechanism for opioid dichotomy: bidirectional effect of ?-opioid receptors on P2X3 receptor currents in rat sensory neurones.
Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor.
Molecular mechanisms for alpha2-adrenoceptor-mediated regulation of synoviocyte populations.
Molecular mechanisms for somatostatin inhibition of c-fos gene expression.
Molecular mechanisms for the activation of Ca2+-permeable nonselective cation channels by endothelin-1 in C6 glioma cells.
Molecular mechanisms for the effect of mastoparan on G proteins in tissues of vertebrates and invertebrates.
Molecular mechanisms for the growth factor action of gastrin.
Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors.
Molecular mechanisms of adenylyl cyclase desensitization in pregnant rat myometrium following in vivo administration of the beta-adrenergic agonist, isoproterenol.
Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity.
Molecular mechanisms of corticotropin-releasing factor receptor-induced calcium signaling.
Molecular mechanisms of homologous desensitization and internalization of muscarinic receptors in primary cultures of neonatal corticostriatal neurons.
Molecular mechanisms of lymphocyte extravasation. III. The loss of lymphocyte extravasation potential induced by pertussis toxin is not mediated via the activation of protein kinase C.
Molecular mechanisms of lymphocyte homing to peripheral lymph nodes.
Molecular mechanisms that control initiation and termination of physiological depolarization-evoked transmitter release.
Molecular mechanisms underlying forskolin-mediated up-regulation of human dopamine D2L receptors.
Molecular model of the G protein alpha subunit based on the crystal structure of the HRAS protein.
Molecular pathways mediating activation by kainate of mitogen-activated protein kinase in oligodendrocyte progenitors.
Molecular regulation of phagocyte function. Evidence for involvement of a guanosine triphosphate-binding protein in opsonin-mediated phagocytosis by monocytes.
Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes.
Molecular typing of Bordetella pertussis isolates recovered from Belgian children and their household members.
Mono(ADP-ribosylation) in rat liver mitochondria.
Monoclonal anti-CD23 antibodies induce a rise in [Ca2+]i and polyphosphoinositide hydrolysis in human activated B cells. Involvement of a Gp protein.
Monoclonal antibodies against pertussis toxin. Biochemical characterization and biological activity.
Monoclonal antibodies against the enzymatic subunit of both pertussis and cholera toxins.
Monoclonal antibodies and toxins--a perspective on function and isotype.
Monoclonal antibodies that define neutralizing epitopes of pertussis toxin: conformational dependence and epitope mapping.
Monoclonal antibodies that inhibit ADP-ribosyltransferase but not NAD-glycohydrolase activity of pertussis toxin.
Monoclonal antibodies to pertussis toxin: utilization as probes of toxin function.
Monoclonal antibody against pertussis toxin: effect on toxin activity and pertussis infections.
Monoclonal antibody against pertussis toxin: relationship between toxin neutralization and mouse protection activities.
Monoclonal antibody that neutralizes pertussis toxin activities.
Monoclonal Lym-1 antibody-targeted lysis of B lymphoma cells by neutrophils. Evidence for two mechanisms of FcgammaRII-dependent cytolysis.
Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration.
Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1.
Monocyte chemoattractant protein-1 selectively inhibits the acquisition of CD40 ligand-dependent IL-12-producing capacity of monocyte-derived dendritic cells and modulates Th1 immune response.
Monocyte chemoattractant protein-1-induced activation of p42/44 MAPK and c-Jun in murine peritoneal macrophages: a potential pathway for macrophage activation.
Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smooth muscle cell proliferation.
Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells.
Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4+ and CD8+ T lymphocytes.
Monocyte migration: a novel effect and signaling pathways of catestatin.
Monocyte Trafficking to Hepatic Sites of Bacterial Infection Is Chemokine Independent and Directed by Focal Intercellular Adhesion Molecule-1 Expression.
Monomeric human IgE evokes a transient calcium rise in individual human neutrophils.
Morphine negatively regulates interferon-gamma promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathways.
Morphine stimulates phagocytosis of Mycobacterium tuberculosis by human microglial cells: involvement of a G protein-coupled opiate receptor.
Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons.
Morphine-induced chemotaxis and brain-derived neurotrophic factor expression in microglia.
Morphine-like opiates selectively antagonize receptor-arrestin interactions.
Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart.
Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal Ca2+ channels.
Most B cells in non-lymphoid tissues are naïve.
Motilin and OHM-11526 activate a calcium current in human and canine jejunal circular smooth muscle.
Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers.
Mouse and Human Eosinophils Degranulate in Response to Platelet-Activating Factor (PAF) and LysoPAF via a PAF-Receptor-Independent Mechanism: Evidence for a Novel Receptor.
Mouse astrocytes respond to the chemokines MCP-1 and KC, but reverse transcriptase-polymerase chain reaction does not detect mRNA for the KC or new MCP-1 receptor.
Mouse bone marrow-derived mast cells undergo exocytosis, prostanoid generation, and cytokine expression in response to G protein-activating polybasic compounds after coculture with fibroblasts in the presence of c-kit ligand.
Mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination: possible involvement of cAMP.
Mouse cerebellar GABAB participation in the expression of acute ethanol-induced ataxia and in its modulation by the cerebellar adenosinergic A1 system.
Mouse lymphoid tissue contains distinct subsets of langerin/CD207 dendritic cells, only one of which represents epidermal-derived Langerhans cells.
Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells.
Mouse retinal ganglion cell signalling is dynamically modulated through parallel anterograde activation of cannabinoid and vanilloid pathways.
MPP(+)-induced cytotoxicity in neuroblastoma cells: Antagonism and reversal by guanosine.
Mr 40,000 and Mr 39,000 pertussis toxin substrates are increased in surgically denervated dog ventricular myocardium.
MrgprX1 Mediates Neuronal Excitability and Itch Through Tetrodotoxin-Resistant Sodium Channels.
MrgX2?mediated internalization of LL?37 and degranulation of human LAD2 mast cells.
mt(1) Receptor-mediated antiproliferative effects of melatonin on the rat uterine antimesometrial stromal cells.
mu and delta opioid agonists at low concentrations decrease voltage-dependent K+ currents in F11 neuroblastoma x DRG neuron hybrid cells via cholera toxin-sensitive receptors.
Mu and delta opioid receptor activation inhibits omega-conotoxin-sensitive calcium channels in a voltage- and time-dependent mode in the human neuroblastoma cell line SH-SY5Y.
Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells.
mu and delta opioid receptors differentially couple to G protein subtypes in membranes of human neuroblastoma SH-SY5Y cells.
Mu and delta opioid receptors inhibit serotonin release in rat hippocampus.
Mu and delta opioids but not kappa opioid inhibit voltage-activated Ba2+ currents in neuronal F-11 cell.
Mu type opioid receptors in rat periaqueductal gray-enriched P2 membrane are coupled to G-protein-mediated inhibition of adenylyl cyclase.
Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect?
Mu-opioid agonist-induced activation of G-protein-coupled inwardly rectifying potassium current in rat periaqueductal gray neurons.
Mu-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via phosphatidylinositol 3-kinase.
Mu-opioid receptor down-regulation and tolerance are not equally dependent upon G-protein signaling.
mu-Opioid receptor forms a functional heterodimer with cannabinoid CB1 receptor: electrophysiological and FRET assay analysis.
mu-Opioid receptor stimulation of inositol (1,4,5)trisphosphate formation via a pertussis toxin-sensitive G protein.
mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G(o)-type GTP-binding protein.
mu-Opioid receptors and not kappa-opioid receptors are coupled to the adenylate cyclase in the cerebellum.
mu-Opioid receptors inhibit dopamine-stimulated activity of type V adenylyl cyclase but enhance dopamine-stimulated activity of type VII adenylyl cyclase.
Mu-type opioid receptors in rat periaqueductal gray-enriched P2 membrane are coupled to guanine nucleotide binding proteins.
Mucosal and systemic immune responses elicited by recombinant Lactococcus lactis expressing a fusion protein composed of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis.
Mucosal and systemic immunogenicity of a recombinant, non-ADP-ribosylating pertussis toxin: effects of formaldehyde treatment.
Mucosal immunization with a genetically engineered pertussis toxin S1 fragment-cholera toxin subunit B chimeric protein.
Mucosal vaccination approach against mosquito-borne Japanese encephalitis virus.
Multilocus sequence typing of Bordetella pertussis based on surface protein genes.
Multiple actions of anandamide on neonatal rat cultured sensory neurones.
Multiple actions of epidermal growth factor and TGF-alpha on rabbit gastric parietal cell function.
Multiple affinity binding states of the sigma receptor: effect of GTP-binding protein-modifying agents.
Multiple agonist-affinity states of opioid receptors: regulation of binding by guanyl nucleotides in guinea pig cortical, NG108-15, and 7315c cell membranes.
Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function.
Multiple discontinuity as a remarkable feature of the development of acellular pertussis vaccines.
Multiple effector coupling of somatostatin receptor subtype SSTR1.
Multiple effects of opiates on intracellular calcium level and on calcium uptake in three neuronal cell lines.
Multiple effects of phorbol ester on secretory activity in rabbit gastric glands and parietal cells.
Multiple G proteins and phospholipase C isoforms in human myometrial cells: implication for oxytocin action.
Multiple G-protein coupling of the dog thyrotropin receptor.
Multiple G-protein involvement in parathyroid hormone regulation of acid production by osteoclasts.
Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons.
Multiple G-protein-dependent pathways mediate the antisecretory effects of somatostatin and clonidine in the HT29-19A colonic cell line.
Multiple Gi protein subtypes regulate a single effector mechanism.
Multiple Gi proteins participate in nerve growth factor-induced activation of c-Jun N-terminal kinases in PC12 cells.
Multiple GTP-binding proteins from cholinergic synaptic vesicles.
Multiple hypothalamic factors regulate pyroglutamyl peptidase II in cultures of adenohypophyseal cells: role of the cAMP pathway.
Multiple isoforms of ADP-ribosylated G-like proteins from mammalian thyroid membranes.
Multiple mechanisms of arachidonic acid release in Chinese hamster ovary cells transfected with cDNA of substance P receptor.
Multiple mechanisms of bradykinin-induced contraction in rat and guinea pig smooth muscles in vitro.
Multiple mechanisms of somatostatin inhibition of adrenocorticotropin release from mouse anterior pituitary tumor cells.
Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein.
Multiple muscarinic pathways mediate the suppression of voltage-gated Ca2+ channels in mouse intestinal smooth muscle cells.
Multiple neurological abnormalities in mice deficient in the G protein Go.
Multiple pathways for signal transduction in the regulation of arachidonic acid metabolism in rat peritoneal macrophages.
Multiple pathways of apolipoprotein E signaling in primary neurons.
Multiple pertussis toxin substrates as candidates for regulatory G proteins of adenylate cyclase coupled to the somatostatin receptor in primary rat astrocytes.
Multiple pertussis toxin-sensitive G-proteins can couple receptors to GIRK channels in rat sympathetic neurons when expressed heterologously, but only native G(i)-proteins do so in situ.
Multiple polyphosphoinositide pathways regulate apoptotic signalling in a dorsal root ganglion derived cell line.
Multiple receptor activation elicits synergistic IP formation in nonpigmented ciliary body epithelial cells.
Multiple recurrences in melanin-protein-induced uveitis in the rat.
Multiple regulation by external ATP of nifedipine-insensitive, high voltage-activated Ca(2+) current in guinea-pig mesenteric terminal arteriole.
Multiple roles of Gi/o protein-coupled receptors in control of action potential secretion coupling in pituitary lactotrophs.
Multiple Sclerosis Gene Therapy with Recombinant Viral Vectors: Overexpression of IL-4, Leukemia Inhibitory Factor, and IL-10 in Wharton's Jelly Stem Cells Used in EAE Mice Model.
Multiple signal transduction pathways lead to extracellular ATP-stimulated mitogenesis in mammalian cells: I. Involvement of protein kinase C-dependent and -independent pathways.
Multiple signal transduction pathways lead to extracellular ATP-stimulated mitogenesis in mammalian cells: II. A pathway involving arachidonic acid release, prostaglandin synthesis, and cyclic AMP accumulation.
Multiple signal transduction pathways mediated by 5-HT receptors.
Multiple signal transduction pathways through two prostaglandin E receptor EP3 subtype isoforms expressed in human uterus.
Multiple Signaling Pathways Contribute to the Thrombin-induced Secretory Phenotype in Vascular Smooth Muscle Cells.
Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells.
Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells.
Multiple signalling pathways in the C5a-induced expression of adhesion receptor Mac-1.
Multiple species and isoforms of Bordetella pertussis toxin substrates.
Multiple T and B cell epitopes in the S1 subunit ("A"-monomer) of the pertussis toxin molecule.
Multiple Transduction Pathways Mediate Thyrotropin Receptor Signaling in Preosteoblast-Like Cells.
Multiple trimeric G-proteins on the trans-Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation.
Multiple weak interactions between BvgA~P and ptx promoter DNA strongly activate transcription of pertussis toxin genes in Bordetella pertussis.
Multiplex LightCycler PCR assay for detection and differentiation of Bordetella pertussis and Bordetella parapertussis in nasopharyngeal specimens.
Multiplex Point-of-Care Tests for the Determination of Antibodies after Acellular Pertussis Vaccination.
Multiplicative interaction between intrathecally and intracerebroventricularly administered morphine for antinociception in the mouse: effects of spinally and supraspinally injected 3-isobutyl-1-methylxanthine, cholera toxin, and pertussis toxin.
Multitarget PCR for diagnosis of pertussis and its clinical implications.
Murine astrocytes express a functional chemokine receptor.
Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2).
Murine Cytomegalovirus Spread Depends on the Infected Myeloid Cell Type.
Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin.
Murine model for pertussis vaccine encephalopathy: role of the major histocompatibility complex; antibody to albumin and to Bordetella pertussis and pertussis toxin.
Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction.
Muscarine activates a nonselective cation current through a M3 muscarinic receptor subtype in rat dorsolateral septal nucleus neurons.
Muscarine and t-LHRH suppress M-current by activating an IAP-insensitive G-protein.
Muscarine increases a voltage-independent potassium conductance through an M4 receptor in rat dorsolateral septal nucleus neurons.
Muscarine inhibits high-threshold calcium currents with two distinct modes in rat embryonic hippocampal neurons.
Muscarine inhibits omega-conotoxin-sensitive calcium channels in a voltage- and time-dependent mode in the human neuroblastoma cell line SH-SY5Y.
Muscarine modulates Ca2+ channel currents in rat sensorimotor pyramidal cells via two distinct pathways.
Muscarine modulation by a G-protein alpha-subunit of delayed rectifier K+ current in rat ventromedial hypothalamic neurones.
Muscarine receptors regulating electrically evoked release of acetylcholine in hippocampus are linked to pertussis toxin-sensitive G proteins but not to adenylate cyclase.
Muscarinic (M1) receptor-mediated inhibition of K(+)-evoked [3H]-noradrenaline release from human neuroblastoma (SH-SY5Y) cells via inhibition of L- and N-type Ca2+ channels.
Muscarinic (m2/m4) receptors reduce N- and P-type Ca2+ currents in rat neostriatal cholinergic interneurons through a fast, membrane-delimited, G-protein pathway.
Muscarinic acetylcholine and histamine-receptor mediated calcium mobilization and cell-growth in human ovarian-cancer cells.
Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex.
Muscarinic acetylcholine receptor produced in recombinant baculovirus infected Sf9 insect cells couples with endogenous G-proteins to activate ion channels.
Muscarinic acetylcholine receptor-mediated phosphoinositide turnover in cultured human retinal pigment epithelium cells.
Muscarinic acetylcholine receptor-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to guanine-nucleotide-binding proteins in cardiac membranes.
Muscarinic acetylcholine receptors in the sino-atrial node and right atrium of bovine heart.
Muscarinic acetylcholine response in pyramidal neurones of rat cerebral cortex.
Muscarinic activation of mitogen-activated protein kinase in PC12 cells.
Muscarinic and purinergic Ca2+ mobilizations in the neural retina of early embryonic chick.
Muscarinic and quisqualate receptor-induced phosphoinositide hydrolysis in primary cultures of striatal and hippocampal neurons. Evidence for differential mechanisms of activation.
Muscarinic Ca2+ responses resistant to muscarinic antagonists at perisynaptic Schwann cells of the frog neuromuscular junction.
Muscarinic cation current and suppression of Ca2+ current in guinea pig ileal smooth muscle cells.
Muscarinic cholinergic agonists stimulate arachidonic acid release from mouse striatal neurons in primary culture.
Muscarinic cholinergic induced secretin subsensitivity in rat isolated pancreatic acini. Effects on amylase release, cyclic adenosine monophosphate and inositol phosphate formation.
Muscarinic cholinergic inhibition of cyclic AMP accumulation in airway smooth muscle. Role of a pertussis toxin-sensitive protein.
Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin.
Muscarinic cholinergic receptor-mediated phosphoinositide metabolism in peripheral nerve.
Muscarinic cholinergic stimulation of inositol phosphate production in cultured embryonic chick atrial cells. Evidence for a role of two guanine-nucleotide-binding proteins.
Muscarinic cholinergic-receptor stimulation of specific GTP hydrolysis related to adenylate cyclase activity in canine cardiac sarcolemma.
Muscarinic control of the hyperpolarization-activated current (if) in rabbit sino-atrial node myocytes.
Muscarinic depression of synaptic transmission and blockade of norepinephrine-induced long-lasting potentiation in the dentate gyrus.
Muscarinic effects on action potential duration and its rate dependence in canine Purkinje fibers.
Muscarinic inhibition of calcium current and M current in Galpha q-deficient mice.
Muscarinic inhibition of L-type Ca2+ channels in guinea-pig tracheal smooth muscle cells.
Muscarinic inhibition of nicotinic transmission in rat sympathetic neurons and adrenal chromaffin cells.
Muscarinic inhibition of single KCa channels in smooth muscle cells by a pertussis-sensitive G protein.
Muscarinic m1 receptor-stimulated adenylate cyclase activity in Chinese hamster ovary cells is mediated by Gs alpha and is not a consequence of phosphoinositidase C activation.
Muscarinic M2 receptors inhibit Ca2+-activated K+ channels in rat bladder smooth muscle.
Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: evidence for M2/M3 receptor interactions.
Muscarinic modulation of calcium current in neurones from the interatrial septum of bull-frog heart.
Muscarinic modulation of TREK currents in mouse sympathetic superior cervical ganglion neurons.
Muscarinic receptor activation modulates Ca2+ channels in rat intracardiac neurons via a PTX- and voltage-sensitive pathway.
Muscarinic receptor activation of potassium channels in rat dentate gyrus neurons.
Muscarinic receptor heterogeneity in neonatal rat ventricular myocytes in culture.
Muscarinic receptor subclassification and G-proteins: significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics.
Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle.
Muscarinic receptor-dependent activation of phospholipase C in human fetal central nervous system organotypic tissue culture.
Muscarinic receptor-linked elevation of cAMP in SH-SY5Y neuroblastoma cells is mediated by Ca2+ and protein kinase C.
Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes.
Muscarinic receptor-mediated hydrolysis of phosphatidylinositols in human neuroblastoma (SH-SY5Y) cells is sensitive to pertussis toxin.
Muscarinic receptor-mediated increase in cAMP levels in SK-N-SH human neuroblastoma cells.
Muscarinic receptors and gastrointestinal tract smooth muscle function.
Muscarinic receptors controlling the carbachol-activated nonselective cationic current in guinea pig gastric smooth muscle cells.
Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways.
Muscarinic receptors in MDCK cells are coupled to multiple messenger systems.
Muscarinic receptors mediate carbachol-induced inhibition of maximal electroshock seizures in the nucleus reticularis pontis oralis.
Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts.
Muscarinic receptors mediate stimulation of human lung fibroblast proliferation.
Muscarinic receptors modulate intracellular calcium level in chick sensory neurons.
Muscarinic receptors stimulate Ca2+ influx via phospholipase A2 pathway in ileal smooth muscles.
Muscarinic receptors, phosphoinositide metabolism and intracellular calcium in neuronal cells.
Muscarinic regulation of basal versus thyrotropin-releasing hormone-induced prolactin secretion in rat anterior pituitary cells. differential roles of nitric oxide and intracellular calcium mobilization.
Muscarinic regulation of Ca2+ oscillation frequency in GH3 cells.
Muscarinic regulation of cyclic AMP in bovine trachealis cells.
Muscarinic regulation of intracellular signaling and neurosecretion in gonadotropin-releasing hormone neurons.
Muscarinic regulation of phospholipase A2 and iodide fluxes in FRTL-5 thyroid cells.
Muscarinic signaling pathway for calcium release and calcium-activated chloride current in smooth muscle.
Muscarinic stimulation of calcium influx and norepinephrine release in PC12 cells.
Muscarinic stimulation of gallbladder epithelium. III. Antagonism of cAMP-mediated effects.
Muscarinic-agonist and guanine nucleotide activation of polyphosphoinositide phosphodiesterase in isolated islet-cell membranes.
Muscarinic-agonist and guanine nucleotide stimulation of myo-inositol trisphosphate formation in membranes isolated from bovine iris sphincter smooth muscle: effects of short-term cholinergic desensitization.
Muscarinic-induced mucin secretion and intracellular signaling by hamster tracheal goblet cells.
Muscarinic-stimulated norepinephrine release and phosphoinositide hydrolysis in PC12 cells are independent events.
Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions.
Mutagenesis studies toward understanding the intracellular signaling mechanism of antithrombin.
Mutants in the ptlA-H genes of Bordetella pertussis are deficient for pertussis toxin secretion.
Mutants of pertussis toxin suitable for vaccine development.
Mutation analysis of pertussis toxin promoter.
Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association.
Mutation of Asp100 in the second transmembrane domain of the cholecystokinin B receptor increases antagonist binding and reduces signal transduction.
Mutational analysis of G protein alpha subunit G(o) alpha expressed in Escherichia coli.
Mutations in the bvgA gene of Bordetella pertussis that differentially affect regulation of virulence determinants.
Mutations in the S1 subunit of pertussis toxin that affect secretion.
Mutations in the third, but not the first or second, hypervariable regions of DR(beta 1*0101) eliminate DR1-restricted recognition of a pertussis toxin peptide.
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity.
Mycobacterium avium complex promotes recruitment of monocyte hosts for HIV-1 and bacteria.
Mycophenolate mofetil and cyclophosphamide treatments suppress inflammation intensity in an experimental model of autoimmune uveitis.
Mycoplasma hyopneumoniae increases intracellular calcium release in porcine ciliated tracheal cells.
Myelin basic protein binds GTP at a single site in the N-terminus.
Myelin oligodendrocyte glycoprotein (MOG35-55) induced experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice.
Myelin oligodendrocyte glycoprotein (MOG35-55)-induced experimental autoimmune encephalomyelitis is ameliorated in interleukin-32 alpha transgenic mice.
Myelin Protein Zero180-199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice.
Myelin/oligodendrocyte glycoprotein-specific T-cells induce severe optic neuritis in the C57BL/6 mouse.
Myeloid cell proliferation stimulated by Steel factor is pertussis toxin sensitive and enhanced by cholera toxin.
Myeloid cells migrate in response to IL-24.
Myenteric ganglionic 5-hydroxytryptamine(1P) signal transmission is mediated via Go protein.
Myocardial beta-adrenergic receptor expression and signal transduction after chronic volume-overload hypertrophy and circulatory congestion.
Myocardial beta-adrenoceptors and inhibitory G-proteins in myocardial biopsies and in explanted hearts from patients with dilated cardiomyopathy.
Myocardial Gi alpha-protein levels in patients with hypertensive cardiac hypertrophy, ischemic heart disease and cardiogenic shock.
Myogenic tone is coupled to phospholipase C and G protein activation in small cerebral arteries.
Myr+-Gi2 alpha and Go alpha subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice.
Mystixin-7 and mystixin-11 increase cytosolic free Ca2+ and inositol trisphosphates in human A-431 cells.
N-acetyl beta-endorphin-(1-31) and substance P regulate the supraspinal antinociception mediated by mu opioid and alpha-2 adrenoceptors but not by delta opioid receptors in the mouse.
N-acetylaspartylglutamate and beta-NAAG protect against injury induced by NMDA and hypoxia in primary spinal cord cultures.
N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells.
N-acetylated Proline-Glycine-Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release.
N-acetylation of serotonin is correlated with alpha 2- but not with beta-adrenergic regulation of cyclic AMP levels in cultured chick pineal cells.
N-arachidonoyl glycine induces macrophage apoptosis via GPR18.
N-arachidonoyl glycine, an endogenous lipid that acts as a vasorelaxant via nitric oxide and large conductance calcium-activated potassium channels.
N-ethylmaleimide blocks depolarization-induced suppression of inhibition and enhances GABA release in the rat hippocampal slice in vitro.
N-Ethylmaleimide differentiates between the M2- and M4-autoreceptor-mediated inhibition of acetylcholine release in the mouse brain.
N-ethylmaleimide diminishes alpha 2-adrenoceptor-mediated effects on norepinephrine release in rat tail arteries.
N-ethylmaleimide increases the L-type calcium current in guinea-pig ventricular myocytes.
N-Formyl peptide receptor ligation induces rac-dependent actin reorganization through Gbeta gamma subunits and class Ia phosphoinositide 3-kinases.
N-formyl-methionyl-leucyl-phenylalanine induces and modulates IL-1 and IL-6 in human PBMC.
N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures.
N-Methyl-d-aspartate receptor antagonist d-AP5 prevents pertussis toxin-induced alterations in rat spinal cords by inhibiting increase in concentrations of spinal CSF excitatory amino acids and downregulation of glutamate transporters.
N-methyl-N'-nitro-N-nitrosoguanidine: the effect on migration and cGMP level of neutrophils.
N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons.
N-terminal chromogranin-derived peptides as dilators of bovine coronary resistance arteries.
N-type Ca(2+) -channels in murine pancreatic beta-cells are inhibited by an exclusive coupling with somatostatin receptor subtype 1.
N1E-115 mouse neuroblastoma cells express MT1 melatonin receptors and produce neurites in response to melatonin.
N36, a synthetic N-terminal heptad repeat domain of the HIV-1 envelope protein gp41, is an activator of human phagocytes.
N6-isopentenyladenosine affects cAMP-dependent microfilament organization in FRTL-5 thyroid cells.
Na(+)-dependent metabolic coupling upon 5-HT1B receptor activation by sumatriptan and related agonists.
Na(+)-K(+)-ATPase-G protein coupling in myocardial sarcolemma: separation and reconstitution.
Na+ regulation of formyl peptide receptor-mediated signal transduction in HL 60 cells. Evidence that the cation prevents activation of the G-protein by unoccupied receptors.
Na+/H+ exchange and the regulation of intracellular pH in polymorphonuclear leukocytes.
Na+/H+ exchange in hypertension and in diabetes mellitus--facts and hypotheses.
NADP efficiently inhibits endogenous but not pertussis toxin-catalyzed covalent modification of membrane proteins incubated with NAD.
NADP+ enhances cholera and pertussis toxin-catalyzed ADP-ribosylation of membrane proteins.
NADPH-oxidase-dependent reactive oxygen species mediate EGFR transactivation by FPRL1 in WKYMVm-stimulated human lung cancer cells.
NaF and guanine nucleotides modulate adenylate cyclase activity in NG108-15 cells by interacting with both Gs and Gi.
Naïve T cells re-distribute to the lungs of selectin ligand deficient mice.
Naloxone in ultralow concentration restores endomorphin-1-evoked Ca(2+) signaling in lipopolysaccharide pretreated astrocytes.
NANC inhibitory neuromuscular transmission in the hamster distal colon.
Naphazoline-induced suppression of aqueous humor pressure and flow: involvement of central and peripheral alpha(2)/I(1) receptors.
Nasopharyngeal pertussis toxin IgA antibodies in the diagnosis of pertussis in Australian community patients.
Native 5-HT1B receptors expressed in OK cells display dual coupling to elevation of intracellular calcium concentrations and inhibition of adenylate cyclase.
Native and genetically inactivated pertussis toxins induce human dendritic cell maturation and synergize with lipopolysaccharide in promoting T helper type 1 responses.
Native low density lipoprotein-induced calcium transients trigger VCAM-1 and E-selectin expression in cultured human vascular endothelial cells.
Native, but not genetically inactivated, pertussis toxin protects mice against experimental allergic encephalomyelitis.
Natriuretic peptide receptor-C agonist attenuates the expression of cell cycle proteins and proliferation of vascular smooth muscle cells from spontaneously hypertensive rats: role of Gi proteins and MAPkinase/PI3kinase signaling.
NATRIURETIC PEPTIDE RECEPTOR-C UNDERPINS THE DISPARATE REGULATION OF ENDOTHELIAL AND VASCULAR SMOOTH MUSCLE CELL PROLIFERATION BY C-TYPE NATRIURETIC PEPTIDE.
Natriuretic peptides inhibit adenylyl cyclase activity in dispersed eel gill cells.
Natural competence for DNA transformation in Helicobacter pylori: identification and genetic characterization of the comB locus.
Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein.
Natural polyamines stimulate G-proteins.
Naturally occurring opioid receptor agonists stimulate adenylate cyclase activity in rat olfactory bulb.
Nature and functioning of the pertussis toxin-sensitive G protein of neutrophils.
Nature of DNA binding and RNA polymerase interaction of the Bordetella pertussis BvgA transcriptional activator at the fha promoter.
Nature of thrombin-induced sustained increase in cytosolic calcium concentration in cultured endothelial cells.
Needle-free and adjuvant-free epicutaneous boosting of pertussis immunity: Preclinical proof of concept.
Neferine, a bisbenzylisoquinoline alkaloid of Nelumbo nucifera, inhibits glutamate release in rat cerebrocortical nerve terminals through 5-HT1A receptors.
Negative and positive inotropic responses to muscarinic agonists in guinea pig and rat atria in vitro.
Negative chronotropic and inotropic effects of endothelin isopeptides in mammalian cardiac muscle.
Negative inotropic action of alpha-1a adrenoceptor blocking agents: role of adenosine and ATP-sensitive K+ channels.
Neomycin induces high-affinity agonist binding of G-protein-coupled receptors.
Neomycin is a potent secretagogue of mast cells that directly activates a GTP-binding protein involved in exocytosis.
Neomycin mimics the effects of high extracellular calcium concentrations on parathyroid function in dispersed bovine parathyroid cells.
Neonatal immunization with a single dose of recombinant BCG expressing subunit S1 from pertussis toxin induces complete protection against Bordetella pertussis intracerebral challenge.
Nerve growth factor changes G protein levels and localization in PC12 cells.
Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells.
Nerve growth factor stimulation of p42/p44 mitogen-activated protein kinase in PC12 cells: role of G(i/o), G protein-coupled receptor kinase 2, beta-arrestin I, and endocytic processing.
Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via G(i/o) proteins.
Nesfatin-1 increases intracellular calcium concentration by protein kinase C activation in cultured rat dorsal root ganglion neurons.
Nesfatin-1 Suppresses Cardiac L-type Ca²? Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway.
Nesfatin-1: distribution and interaction with a g protein-coupled receptor in the rat brain.
Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity.
Neural effects of parathyroid hormone: modulation of the calcium channel current and metabolism of monoamines in identified Helisoma snail neurons.
Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon.
Neurite outgrowth of spinal neurons on tissue sections of embryonic muscle is largely integrin dependent.
Neurite outgrowth-stimulating activities of beta-casomorphins in Neuro-2a mouse neuroblastoma cells.
Neuroblastoma differentiation involves the expression of two isoforms of the alpha-subunit of Go.
Neurochemical and behavioural evidence that dopamine D-2 receptors in striatum couple to the Ni regulatory protein and inhibition of cyclic AMP accumulation.
Neuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin.
Neuromedin U inhibits T-type Ca2+ channel currents and decreases membrane excitability in small dorsal root ganglia neurons in mice.
Neuromedin U uses G?i2 and G?o to suppress glucose-stimulated Ca2+ signaling and insulin secretion in pancreatic ? cells.
Neuromedin-B receptor transfected BALB/3T3 cells: signal transduction and effects of ectopic receptor expression on cell growth.
Neuromodulatory effect of the atrial natriuretic factor clearance receptor binding peptide, cANF(4-23)-NH2 in rabbit isolated vasa deferentia.
Neuromodulatory effects of atrial natriuretic factor are independent of guanylate cyclase in adrenergic neuronal pheochromocytoma cells.
Neuromodulatory effects of atrial natriuretic peptides correlate with an inhibition of adenylate cyclase but not an activation of guanylate cyclase.
Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases.
Neuronal cell apoptosis by a receptor-binding domain peptide of ApoE4, not through low-density lipoprotein receptor-related protein.
Neuronal platelet-activating factor receptor signal transduction involves a pertussis toxin-sensitive G-protein.
Neuropeptide FF receptors couple to a cholera toxin-sensitive G-protein in rat dorsal raphe neurones.
Neuropeptide FF receptors exhibit direct and anti-opioid effects on mice dorsal raphe nucleus neurons.
Neuropeptide Y (18-36) modulates chromaffin cell catecholamine secretion by blocking the nicotinic receptor ion channel.
Neuropeptide Y and hypertension.
Neuropeptide Y and pancreatic polypeptide reduce calcium currents in acutely dissociated neurons from adult rat superior cervical ganglia.
Neuropeptide Y and peptide YY inhibit lipolysis in human and dog fat cells through a pertussis toxin-sensitive G protein.
Neuropeptide Y and sigma ligand (JO 1784) act through a Gi protein to block the psychological stress and corticotropin-releasing factor-induced colonic motor activation in rats.
Neuropeptide Y and truncated neuropeptide Y analogs evoke histamine release from rat peritoneal mast cells. A direct effect on G proteins?
Neuropeptide Y depresses GABA-mediated calcium transients in developing suprachiasmatic nucleus neurons: a novel form of calcium long-term depression.
Neuropeptide Y Directly Inhibits Neuronal Activity in a Subpopulation of Gonadotropin-Releasing Hormone-1 Neurons via Y1 Receptors.
Neuropeptide Y enhances LHRH binding to rat gonadotrophs in primary culture.
Neuropeptide Y increases 4-aminopyridine-sensitive transient outward potassium current in rat ventricular myocytes.
Neuropeptide Y inhibition of calcium channels in PC-12 pheochromocytoma cells.
Neuropeptide Y inhibition of nicotinic receptor-mediated chromaffin cell secretion.
Neuropeptide Y inhibits alpha-MSH release from rat hypothalamic slices through a pertussis toxin-sensitive G protein.
Neuropeptide Y inhibits axonal transport of particles in neurites of cultured adult mouse dorsal root ganglion cells.
Neuropeptide Y inhibits beta-adrenergic agonist- and vasoactive intestinal peptide-induced cyclic AMP accumulation in rat pinealocytes through pertussis toxin-sensitive G protein.
Neuropeptide Y inhibits cardiac adenylate cyclase through a pertussis toxin-sensitive G protein.
Neuropeptide Y inhibits chromaffin cell nicotinic receptor-stimulated tyrosine hydroxylase activity through a receptor-linked G protein-mediated process.
Neuropeptide Y inhibits depolarization-stimulated catecholamine synthesis in rat pheochromocytoma cells.
Neuropeptide Y inhibits forskolin-stimulated adenylate cyclase in bovine adrenal chromaffin cells via a pertussis toxin-sensitive process.
Neuropeptide Y inhibits nicotinic cholinergic currents but not voltage-dependent calcium currents in bovine chromaffin cells.
Neuropeptide Y inhibits pertussis toxin-catalyzed ADP-ribosylation in bovine adrenal chromaffin cell membranes.
Neuropeptide Y inhibits renin release by a pertussis toxin-sensitive mechanism.
Neuropeptide Y inhibits spontaneous alpha-melanocyte-stimulating hormone (alpha-MSH) release via a Y(5) receptor and suppresses thyrotropin-releasing hormone-induced alpha-MSH secretion via a Y(1) receptor in frog melanotrope cells.
Neuropeptide Y inhibits vasoactive intestinal peptide- and dopamine-induced cyclic AMP formation in human Ewing's sarcoma WE-68 cells.
Neuropeptide Y inhibits vasoactive intestinal peptide-stimulated adenylyl cyclase in rat ventral prostate.
Neuropeptide Y mobilizes Ca2+ and inhibits adenylate cyclase in human erythroleukemia cells.
Neuropeptide Y modulates neurotransmitter release and Ca2+ currents in rat sensory neurons.
Neuropeptide Y receptor mediates activation of ERK1/2 via transactivation of the IGF receptor.
Neuropeptide Y receptor-mediated sensitization of ATP-stimulated inositol phosphate formation.
Neuropeptide Y reduces calcium current and inhibits acetylcholine release in nodose neurons via a pertussis toxin-sensitive mechanism.
Neuropeptide Y reduces macromolecule permeability of coronary endothelial monolayers.
Neuropeptide Y secretion from bovine chromaffin cells inhibits cyclic AMP accumulation.
Neuropeptide Y stimulates DNA synthesis in vascular smooth muscle cells.
Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from superfused hypothalamic GT1-7 cells.
Neuropeptide Y stimulates proliferation of human vascular smooth muscle cells: cooperation with noradrenaline and ATP.
Neuropeptide Y stimulation of myosin light chain phosphorylation in cultured aortic smooth muscle cells.
Neuropeptide Y Y1 and Y2 receptor-mediated stimulation of mitogen-activated protein kinase activity.
Neuropeptide Y Y2 receptor and somatostatin sst2 receptor coupling to mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells.
Neuropeptide Y Y2 receptor signalling mechanisms in the human glioblastoma cell line LN319.
Neuropeptide Y Y2 receptor-mediated attenuation of neurogenic plasma extravasation acting through pertussis toxin-sensitive mechanisms.
Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line.
Neuropeptide Y-induced intracellular Ca2+ increases in vascular smooth muscle cells.
Neuropeptide Y2 receptors on nerve endings from the rat neurohypophysis regulate vasopressin and oxytocin release.
Neuropeptide-Y stimulation of extracellular signal-regulated kinases in human erythroleukemia cells.
Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis.
Neuroprotective effects of riluzole on N-methyl-D-aspartate- or veratridine-induced neurotoxicity in rat hippocampal slices.
Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease.
Neuroprotective signal transduction in model motor neurons exposed to thrombin: G-protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis.
Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors.
Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism.
Neurosteroids stimulate G protein-coupled sigma receptors in mouse brain synaptic membrane.
Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.
Neurotensin and acetylcholine evoke common responses in frog oocytes injected with rat brain messenger ribonucleic acid.
Neurotensin and substance P inhibit low- and high-voltage-activated Ca2+ channels in cultured newborn rat nucleus basalis neurons.
Neurotensin decreases the affinity of dopamine D2 agonist binding by a G protein-independent mechanism.
Neurotensin excitation of rat ventral tegmental neurones.
Neurotensin increases the cationic conductance of rat substantia nigra dopaminergic neurons through the inositol 1,4,5-trisphosphate-calcium pathway.
Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn.
Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism.
Neurotensin modulates the electrical activity of frog pituitary melanotropes via activation of a G-protein-coupled receptor pharmacologically related to both the NTS1 and nts2 receptors of mammals.
Neurotensin stimulates inositol trisphosphate-mediated calcium mobilization but not protein kinase C activation in HT29 cells. Involvement of a G-protein.
Neurotensin stimulation of mast cell secretion is receptor-mediated, pertussis-toxin sensitive and requires activation of phospholipase C.
Neurotensin type 1 receptor-mediated activation of krox24, c-fos and Elk-1: preventing effect of the neurotensin antagonists SR 48692 and SR 142948.
Neurotensin, bradykinin and somatostatin inhibit cAMP production in neuroblastoma N1E115 cells via both pertussis toxin sensitive and insensitive mechanisms.
Neurotensin-mediated inhibition of cyclic AMP formation in neuroblastoma N1E115 cells: involvement of the inhibitory GTP-binding component of adenylate cyclase.
Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.
Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target.
Neurotoxicity of Bordetella pertussis.
Neurotransmitter modulation of calcium channels in rat sympathetic neurons.
Neutralization of pertussis toxin by a single antibody prevents clinical pertussis in neonatal baboons.
Neutralizing antibodies and immunoprotection against pertussis and tetanus obtained by use of a recombinant pertussis toxin-tetanus toxin fusion protein.
Neutralizing antibodies to pertussis toxin in whooping cough.
Neutralizing tumor necrosis factor-alpha activity suppresses activation of infiltrating macrophages in experimental autoimmune uveoretinitis.
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor.
Neutrophil activation by inflammatory microcrystals of monosodium urate monohydrate utilizes pertussis toxin-insensitive and -sensitive pathways.
Neutrophil activation by surface bound IgG is via a pertussis toxin insensitive G protein.
Neutrophil activation by surface bound IgG: pertussis toxin insensitive activation.
Neutrophil activation in response to immune complex-bearing endothelial cells depends on the functional cooperation of Fc gamma RII (CD32) and Fc gamma RIII (CD16).
Neutrophil activation induced by the lectin KM+ involves binding to CXCR2.
Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A).
Neutrophil chemotaxis by pathogen-associated molecular patterns--formylated peptides are crucial but not the sole neutrophil attractants produced by Staphylococcus aureus.
Neutrophil chemotaxis induced by the diacylglycerol kinase inhibitor R59022.
Neutrophil CR3 expression and specific granule exocytosis are controlled by different signal transduction pathways.
Neutrophil defensins induce histamine secretion from mast cells: mechanisms of action.
Neutrophil elastase and proteinase-3 trigger G-protein biased signaling through proteinase activated receptor-1 (PAR1).
Neutrophil Priming Mechanisms of Sulfolipid-I and N-Formyl-Methionyl-Leucyl-Phenylalanine.
Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit.
Neutrophil thrombospondin receptors are linked to GTP-binding proteins.
New actions of melatonin on tumor metabolism and growth.
New Data on Vaccine Antigen Deficient Bordetella pertussis Isolates.
New roles for RGS2, 5 and 8 on the ratio-dependent modulation of recombinant GIRK channels expressed in Xenopus oocytes.
New, practical approach to detecting antibody to pertussis toxin for public health and clinical laboratories.
Newly synthesized catalytic and regulatory components of adenylate cyclase are expressed in neurites of cultured sympathetic neurons.
NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells.
NG2/HMPG modulation of human articular chondrocyte adhesion to type VI collagen is lost in osteoarthritis.
Ni-mediated inhibition of human platelet adenylate cyclase by thrombin.
Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2.
Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways.
Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells.
Niacin stimulates adiponectin secretion through the GPR109A receptor.
Nicotine-induced antinociception in mice: role of G-proteins and adenylate cyclase.
Nicotinic acid increases adiponectin secretion from differentiated bovine preadipocytes through G-protein coupled receptor signaling.
Nicotinic Acid Inhibits Glucose-Stimulated Insulin Secretion Via the G Protein-Coupled Receptor PUMA-G in Murine Islet ? Cells.
Nicotinic and muscarinic acetylcholine responses in differentiated PC12 cells.
Nifedipine-sensitive vascular reactivity of femoral arteries in WKY: the effects of pertussis toxin pretreatment and endothelium removal.
NIH3T3 cells expressing the deleted in colorectal cancer tumor suppressor gene product stimulate neurite outgrowth in rat PC12 pheochromocytoma cells.
Nitric oxide and cyclic nucleotides participate in the relaxation of diclofenac on rat uterine smooth muscle.
Nitric oxide and G proteins mediate the response of bovine articular chondrocytes to fluid-induced shear.
Nitric oxide attenuates alpha(2)-adrenergic receptors by ADP-ribosylation of G(i)alpha in ciliary epithelium.
Nitric oxide induction by pertussis toxin in mouse spleen cells via gamma interferon.
Nitric oxide modulates ?-opioid receptor function in vitro.
Nitric oxide signaling mediates stimulation of L-type Ca2+ current elicited by withdrawal of acetylcholine in cat atrial myocytes.
Nitric oxide-independent, thiol-associated ADP-ribosylation inactivates aldehyde dehydrogenase.
Nitroimidazole derivatives inhibit anterior pituitary cell function apparently by a direct effect on the catalytic subunit of the adenylate cyclase holoenzyme.
Nitroxide stable radical suppresses autoimmune uveitis in rats.
NK Cells Regulate CD8+ T Cell Priming and Dendritic Cell Migration during Influenza A Infection by IFN-? and Perforin-Dependent Mechanisms.
NK-LAK induction with IL-2 is regulated by tyrosine phosphorylation of a 105-110 kDa protein.
NMR studies on the structure/function correlations of T-cell-epitope analogs from pertussis toxin.
No effect of pertussis toxin on peripheral prejunctional alpha 2-adrenoceptor-mediated responses and on endothelium-dependent relaxations in the rat.
Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.
Nociceptin (ORL-1) and mu-opioid receptors mediate mitogen-activated protein kinase activation in CHO cells through a Gi-coupled signaling pathway: evidence for distinct mechanisms of agonist-mediated desensitization.
Nociceptin Inhibits Uterine Contractions in Term-Pregnant Rats by Signaling Through Multiple Pathways.
Nociceptin is a potent inhibitor of N-type Ca(2+) channels in rat sympathetic ganglion neurons.
Nociceptin/orphanin FQ activates mitogen-activated protein kinase in Chinese hamster ovary cells expressing opioid receptor-like receptor.
Nociceptin/orphanin FQ activates protein kinase C, and this effect is mediated through phospholipase C/Ca2+ pathway.
Nociceptin/Orphanin FQ peptide receptor (NOP) mediates inhibition of N-type calcium currents in vestibular afferent neurons of the rat.
Nociception activates Elk-1 and Sap1a following expression of the ORL1 receptor in Chinese hamster ovary cells.
Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively.
Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic G(i/o) protein linked pathways.
Nod factors activate both heterotrimeric and monomeric G-proteins in Vigna unguiculata (L.) Walp.
Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 G(i/o) linked receptor.
Non-activated APJ suppresses the angiotensin II type 1 receptor, whereas apelin-activated APJ acts conversely.
Non-additive potentiation of glutamate release by phorbol esters and metabotropic mGlu7 receptor in cerebrocortical nerve terminals.
Non-anticoagulant heparin increases endothelial nitric oxide synthase activity: role of inhibitory guanine nucleotide proteins.
Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma.
Non-classical regulation of ?1- and ? 2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi.
Non-genomic action of the mineralocorticoid aldosterone on cytosolic sodium in cultured kidney cells.
Non-genomic effects of 17beta-estradiol in activation of the ERK1/ERK2 pathway induces cell proliferation through upregulation of cyclin D1 expression in bovine artery endothelial cells.
Non-genomic mechanisms of glucocorticoid inhibition of adrenocorticotropin secretion: possible involvement of GTP-binding protein.
Non-neuronal release of ATP and inositol 1,4,5-trisphosphate accumulation evoked by P2- and M-receptor stimulation in guinea pig ileal segments.
Non-phosphorylated FTY720 Induces Apoptosis of Human Microglia by Activating SREBP2.
Non-steady state kinetic analysis of the regulation of adenylate cyclase by GTP-binding proteins.
Non-steroidal anti-inflammatory drugs: effects on a GTP binding protein within the neutrophil plasma membrane.
Nonbiocompatible hemodialysis membranes induce apoptosis in mononuclear cells: the role of G-proteins.
Noncanonical signaling by ionotropic kainate receptors.
Noncoordinate regulation of alpha-1 adrenoreceptor coupling and reexpression of alpha skeletal actin in myocardial infarction-induced left ventricular failure in rats.
Nongenomic actions of 1,25-dihydroxyvitamin D3 in rat osteosarcoma cells: structure-function studies using ligand analogs.
Nongenomic aldosterone effects: the cell membrane as a specific target of mineralocorticoid action.
Nongenomic effect of testosterone on chloride secretion in cultured rat efferent duct epithelia.
Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes.
Nongenomic effects of androstenedione on human granulosa luteinizing cells.
Nongenomic mechanism of glucocorticoid inhibition of bradykinin-induced calcium influx in PC12 cells: possible involvement of protein kinase C.
Nongenomic mechanisms of glucocorticoid inhibition of nicotine-induced calcium influx in PC12 cells: involvement of protein kinase C.
Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1.
Nonpathogenic, environmental fungi induce activation and degranulation of human eosinophils.
Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells.
Nonrestricted differential intoxication of cells by pertussis toxin.
Nonselective cation channels activated by the stimulation of muscarinic receptors in mammalian gastric smooth muscle.
Nonselective cationic currents activated by acetylcholine in swine tracheal smooth muscle cells.
Nootropic drug modulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons.
NOP receptor pharmacological profile - A dynamic mass redistribution study.
Noradrenaline and alpha-adrenergic signaling induce the hsp70 gene promoter in mollusc immune cells.
Noradrenaline release enhanced by cholera toxin and pertussis toxin in rat cerebral cortical slices.
Noradrenaline release from rat sympathetic neurones triggered by activation of B2 bradykinin receptors.
Noradrenaline stimulates 5-hydroxytryptamine release from mouse ileal tissues via alpha(2)-adrenoceptors.
Noradrenaline- and Enkephalin-Induced Inhibition of Voltage-Sensitive Calcium Currents in NG108-15 Hybrid Cells.
Noradrenaline-induced cation currents in isolated rat paratracheal ganglion neurons.
Noradrenaline-mediated contractions of ovine uterine artery: role of inositol 1,4,5-trisphosphate.
Noradrenergic inhibition and voltage-dependent facilitation of omega-conotoxin-sensitive Ca channels in insulin-secreting RINm5F cells.
Noradrenergic modulation of synaptic transmission between olfactory bulb neurons in culture: implications to olfactory learning.
Noradrenergic potentiation of cerebellar Purkinje cell responses to GABA: cyclic AMP as intracellular intermediary.
Norepinephrine and neuropeptide Y increase intracellular Ca2+ in cultured porcine aortic smooth muscle cells.
Norepinephrine attenuates serotonin inhibition of pial venous tone.
Norepinephrine down-regulates the activity of protein S on endothelial cells.
Norepinephrine inhibits a Ca2+ current in rat sympathetic neurons via a G-protein.
Norepinephrine inhibits calcium currents and EPSPs via a G-protein-coupled mechanism in olfactory bulb neurons.
Norepinephrine modulates high voltage-activated calcium channels in freshly dissociated rat nucleus tractus solitarii neurons.
Norepinephrine release and neuropeptide Y in medulla oblongata of spontaneously hypertensive rats.
Norepinephrine, acting via adenylate cyclase, inhibits melatonin output but does not phase-shift the pacemaker in cultured chick pineal cells.
Norepinephrine-induced calcium mobilization in C6 glioma cells.
Norepinephrine-stimulated PI hydrolysis in oligodendrocytes is mediated by alpha 1A-adrenoceptors.
Normal autophagic activity in macrophages from mice lacking G?i3, AGS3, or RGS19.
Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice.
Nosocomial pertussis in healthcare workers from a pediatric emergency unit in France.
Novel bacterial ADP-ribosylating toxins: structure and function.
Novel biological property of pertussis toxin: chemotactic activity on human monocytes.
Novel bradykinin signalling events in PC-12 cells: stimulation of the cAMP pathway leads to cAMP-mediated translocation of protein kinase Cepsilon.
Novel CD47-dependent intercellular adhesion modulates cell migration.
Novel configurations of high molecular weight species of the pertussis toxin vaccine component.
Novel gamete receptors that facilitate sperm adhesion to the egg coat.
Novel GTP-binding proteins in plasma membranes of the fungus Metarhizium anisopliae.
Novel inhibition of gbetagamma-activated potassium currents induced by M(2) muscarinic receptors via a pertussis toxin-insensitive pathway.
Novel isoforms of Mel1c melatonin receptors modulating intracellular cyclic guanosine 3',5'-monophosphate levels.
Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells.
Novel mechanism for non-genomic action of 17 beta-oestradiol on kainate-induced currents in isolated rat CA1 hippocampal neurones.
Novel metabotropic glutamate receptor negatively coupled to adenylyl cyclase in cultured rat cerebellar astrocytes.
Novel method for following lymphocyte traffic in mice using [3H]glycerol labeling.
Novel mitogenic effect of adenosine on coronary artery smooth muscle cells: role for the A1 adenosine receptor.
Novel model of integration of signaling pathways in rat pancreatic acinar cells.
Novel modulatory effect of L-type calcium channels at newly formed neuromuscular junctions.
Novel molecular biology approaches to acellular vaccines.
Novel multitarget real-time PCR assay for rapid detection of Bordetella species in clinical specimens.
Novel regulatory properties of human type 9 adenylate cyclase.
Novel role of Gi?2 in cell migration: Downstream of PI3-kinase-AKT and Rac1 in prostate cancer cells.
Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion.
Novel Targeting to XCR1+ Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes.
NPY-(18-36) and pertussis toxin distinguish between the negative and positive contractile effects of neuropeptide Y (NPY) in ventricular cardiomyocytes.
NPY-stimulated Ca2+ mobilization in SK-N-MC cells is enhanced after isoproterenol treatment.
Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors.
Nuclear factor-kappaB activation regulates cyclooxygenase-2 induction in human astrocytes in response to CXCL12: role in neuronal toxicity.
Nuclear membrane R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells.
Nucleotide exchange and cGMP phosphodiesterase activation by pertussis toxin inactivated transducin.
Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.
Nucleotide responses of human neutrophils.
Nucleotide sequence homology to pertussis toxin gene in Bordetella bronchiseptica and Bordetella parapertussis.
Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells.
Nucleotide-independent modulation of Ca(2+)-dependent K+ channel current by a mu-type opioid receptor.
Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells.
Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors.
Obestatin-mediated proliferation of human retinal pigment epithelial cells: regulatory mechanisms.
Occurrence and biochemical characterization of GTP-binding proteins in Candida albicans.
Octreotide inhibition of serotonin-induced ileal chloride secretion.
Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression.
Oestradiol-induced relaxation of rabbit basilar artery by inhibition of voltage-dependent Ca channels through GTP-binding protein.
Oestrogen exerts anti-inflammation via p38 MAPK/NF-?B cascade in adipocytes.
Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors.
Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties.
Oligomerization of neuropeptide Y (NPY) Y2 receptors in CHO cells depends on functional pertussis toxin-sensitive G-proteins.
Omega-agatoxin IVA blocks spinal morphine/clonidine antinociceptive synergism.
On technological and immunological benefits of multivalent single-injection microsphere vaccines.
On the adaptation of endosteal stem cell niche function in response to stress.
On the mechanism of action of dexamethasone in a rat mast cell line (RBL-2H3 cells). Evidence for altered coupling of receptors and G-proteins.
On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins.
On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogen-activated protein kinase.
On the mechanism of G protein beta gamma subunit activation of the muscarinic K+ channel in guinea pig atrial cell membrane. Comparison with the ATP-sensitive K+ channel.
On the mechanism of M-current inhibition by muscarinic m1 receptors in DNA-transfected rodent neuroblastoma x glioma cells.
On the mechanism of muscarinic inhibition of the cardiac Ca current.
On the mechanism of the enhancement of delayed rectifier K+ current by extracellular ATP in guinea-pig ventricular myocytes.
On the mechanism of the interaction of ketamine and halothane in vitro.
On the mechanisms of the growth-promoting effect of prostaglandins in hepatocytes: the relationship between stimulation of DNA synthesis and signaling mediated by adenylyl cyclase and phosphoinositide-specific phospholipase C.
On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones.
On the presynaptic action of baclofen at inhibitory synapses between cultured rat hippocampal neurones.
On the selectivity of the G?q inhibitor UBO-QIC: A comparison with the G?i inhibitor pertussis toxin.
On the transduction mechanism for muscarine-induced inhibition of M-current in cultured rat sympathetic neurones.
Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras.
One-dimensional peptide mapping of the subunits of pertussis toxin.
Ontogenesis of alpha 2-adrenoceptor coupling with GTP-binding proteins in the rat telencephalon.
Ontogenetic and pharmacological studies on metabotropic glutamate receptors coupled to phospholipase D activation.
Ontogenic aspects of D1 receptor coupling to G proteins and regulation of rat jejunal Na+, K+ ATPase activity and electrolyte transport.
Ontogeny of pulmonary neuroendocrine cells which express the alpha-subunit of guanine nucleotide-binding protein Go.
Ontogeny of the inhibitory guanine nucleotide-binding regulatory protein in the rat testis: mRNA expression and modulation of LH and FSH action.
Oocyte adenylyl cyclase contains Ni, yet the guanine nucleotide-dependent inhibition by progesterone is not sensitive to pertussis toxin.
Opening of ATP-sensitive K+ channels responsible for adenosine A2 receptor-mediated vasodepression does not involve a pertussis toxin-sensitive G protein.
Operational characteristics of somatostatin receptors mediating inhibitory actions on rat locus coeruleus neurones.
Opiate and peptide inhibition of transmitter release in parasympathetic nerve terminals.
Opiate-dependent changes in the sensitivity of adenylate cyclase to stimulatory agonists and 5'-guanylylimidodiphosphate are independent of G protein abundance and eukaryotic ADP-ribosyltransferase activity in NG108-15 cells.
Opiate-inhibited adenylate cyclase in rat brain membranes depleted of Gs-stimulated adenylate cyclase.
Opiate-mediated inhibition of calcium signaling is decreased in dorsal root ganglion neurons from the diabetic BB/W rat.
Opioid analgesic-induced apoptosis and caspase-independent cell death in human lung carcinoma A549 cells.
Opioid and cannabinoid receptor inhibition of adenylyl cyclase in brain.
Opioid dependence prevents the action of pertussis toxin in the guinea-pig myenteric plexus.
Opioid effects on contractility, Ca(2+)-transients and intracellular pH in cultured cardiac myocytes.
Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor.
Opioid efficacy in a C6 glioma cell line stably expressing the human kappa opioid receptor.
Opioid inhibition and desensitization of calcium channel currents in rat dorsal root ganglion neurons.
Opioid inhibition of adenylyl cyclase in membranes from pertussis toxin-treated NG108-15 cells.
Opioid inhibition of Ca2+ channel subtypes in bovine chromaffin cells: selectivity of action and voltage-dependence.
Opioid modulation of calcium current in cultured sensory neurons: mu-modulation of baroreceptor input.
Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits.
Opioid peptide receptor stimulation reverses beta-adrenergic effects in rat heart cells.
Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (Gi) in membranes of neuroblastoma x glioma hybrid cells.
Opioid potentiation of N-type Ca2+ channel currents via pertussis-toxin-sensitive G proteins in NG108-15 cells.
Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma.
Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: Functional interactions with casein kinase Ialpha, Galpha(i) proteins, and ERK1/2 signaling.
Opioid receptor and calcium channel regulation of adenylyl cyclase, modulated by GM1, in NG108-15 cells: competitive interactions.
Opioid receptor-mediated effects of interleukin-2 on the [Ca2+]i transient and contraction in isolated ventricular myocytes of the rat.
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Opioid receptors are coupled tightly to G proteins but loosely to adenylate cyclase in NG108-15 cell membranes.
Opioid receptors in magnesium-digitonin-solubilized rat brain membranes are tightly coupled to a pertussis toxin-sensitive guanine nucleotide-binding protein.
Opioid receptors of neuroblastoma cells are in two domains of the plasma membrane that differ in content of G proteins.
Opioid signal transduction in intact and fragmented SH-SY5Y neural cells.
Opioid-induced adenylyl cyclase supersensitization in human embryonic kidney 293 cells requires pertussis toxin-sensitive G proteins other than G(i1) and G(i3).
Opioid-induced Down-Regulation of RGS4: ROLE OF UBIQUITINATION AND IMPLICATIONS FOR RECEPTOR CROSS-TALK.
Opioid-induced increase in [Ca2+]i in ND8-47 neuroblastoma x dorsal root ganglion hybrid cells is mediated through G protein-coupled delta-opioid receptors and desensitized by chronic exposure to opioid.
Opioid-Mediated Modulation of Acid-Sensing Ion Channel Currents in Adult Rat Sensory Neurons.
Opioids as modulators of cell death and survival--unraveling mechanisms and revealing new indications.
Opioids binding mu and delta receptors exhibit diverse efficacy in the activation of Gi2 and G(x/z) transducer proteins in mouse periaqueductal gray matter.
Opioids excite rather than inhibit sensory neurons after chronic opioid exposure of spinal cord-ganglion cultures.
Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells.
Opioids inhibit purinergic nociceptors in the sensory neurons and fibres of rat via a G protein-dependent mechanism.
Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells.
Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts.
Opposing effects of acetylcholine on the two classes of voltage-dependent calcium channels in hippocampal neurons.
Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein.
Opposing effects of fibroblast growth factor and pertussis toxin on alkaline phosphatase, osteopontin, osteocalcin, and type I collagen mRNA levels in ROS 17/2.8 cells.
Opposing influences of dexamethasone and retinoic acid on adenylate cyclase activity in ROS 17/2.8 cells.
Opposite action of beta1- and beta2-adrenergic receptors on Ca(V)1 L-channel current in rat adrenal chromaffin cells.
Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o).
Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate tetralithium and 2-methylthioadenosine-5'-diphosphate trisodium: mechanisms involved.
Opposite paracrine effects of 5-HT and dopamine on Na(+)-Pi cotransport in opossum kidney cells.
Opposite, phase-dependent effects of 3,4,5-trimethoxybenzoic acid 8-(diethylamino) octyl ester or tetracaine on islet function during three phases of glucose-stimulated insulin secretion.
Opsonophagocytic activity and other serological indications of Bordetella pertussis infection in military recruits in Norway.
Optical neuritis induced by different concentrations of myelin oligodendrocyte glycoprotein presents different profiles of the inflammatory process.
Optimal conditions for the toxoiding of pertussis toxin with 1-ethyl-3(3-dimethylaminopropyl) carbodiimide.HCl.
Optimization of rPDT fusion protein expression by Escherichia coli in pilot scale fermentation: a statistical experimental design approach.
Optimization of sample preparation for culture-independent sequencing of Bordetella pertussis.
Oral colonization and immune responses to Streptococcus gordonii expressing a pertussis toxin S1 fragment in mice.
Orexin (hypocretin) effects on constitutively active inward rectifier K+ channels in cultured nucleus basalis neurons.
Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins.
Orexin-A differentially modulates AMPA-preferring responses of ganglion cells and amacrine cells in rat retina.
Orexin-A protects against oxygen-glucose deprivation/reoxygenation-induced cell damage by inhibiting endoplasmic reticulum stress-mediated apoptosis via the Gi and PI3K signaling pathways.
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus.
Orexins/Hypocretins Acting at G(i) Protein-Coupled OX (2) Receptors Inhibit Cyclic AMP Synthesis in the Primary Neuronal Cultures.
Organophosphate-induced alterations in muscarinic receptor binding and phosphoinositide hydrolysis in the human SK-N-SH cell line.
Osteopontin expression in the brain triggers localized inflammation and cell death when immune cells are activated by pertussis toxin.
Outbreak of pertussis in a residential facility for handicapped people.
Outer membrane vesicles as acellular vaccine against pertussis.
Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate.
Outer Membrane Vesicles of Bordetella pertussis encapsulated into sodium alginate nanoparticles as novel vaccine delivery system.
Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer.
Overcoming Codon-Usage Bias in Heterologous Protein Expression in Streptococcus gordonii.
Overexpression of beta 1 and beta 2 adrenergic receptors in rat atrial myocytes. Differential coupling to G protein-gated inward rectifier K(+) channels via G(s) and G(i)/o.
Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury.
Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia.
Overexpression of the RNA polymerase alpha subunit reduces transcription of Bvg-activated virulence genes in Bordetella pertussis.
Overview of currently available Japanese acellular pertussis vaccines and future problems.
Overview of recent clinical trials of acellular pertussis vaccines.
OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms.
Oxidant-mediated activation of cytosolic phospholipase a(2) in pulmonary endothelium: role of protein kinase C alpha and a pertussis toxin-sensitive protein.
Oxidized lipids and lysophosphatidylcholine induce the chemotaxis and intracellular calcium influx in natural killer cells.
Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide.
Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids.
Oxidized low-density lipoprotein stimulates protein kinase C (PKC) and induces expression of PKC-isotypes via prostaglandin-H-synthase in P388D1 macrophage-like cells.
Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway.
OxLDL induces mitogen-activated protein kinase activation mediated via PI3-kinase/Akt in vascular smooth muscle cells.
OxLDL upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38 mitogen-activated protein kinase.
Oxygen alters caveolin-1 and nitric oxide synthase-3 functions in ovine fetal and neonatal lung microvascular endothelial cells.
Oxygen pressure-dependent control of carbonic anhydrase synthesis in chick embryonic erythrocytes.
Oxymetazoline inhibits adenylate cyclase by activation of serotonin-1 receptors in the OK cell, an established renal epithelial cell line.
Oxytocin activates mitogen-activated protein kinase and up-regulates cyclooxygenase-2 and prostaglandin production in human myometrial cells.
Oxytocin and lysophosphatidic acid induce stress fiber formation in human myometrial cells via a pathway involving Rho-kinase.
Oxytocin Downregulates the CaV1.2 L-Type Ca2+ Channel via Gi/cAMP/PKA/CREB Signaling Pathway in Cardiomyocytes.
Oxytocin induced a biphasic increase in the intracellular Ca2+ concentration of porcine myometrial cells: participation of a pertussis toxin-insensitive G-protein, inositol 1,4,5-trisphosphate-sensitive Ca2+ pool, and Ca2+ channels.
Oxytocin induces the migration of prostate cancer cells: involvement of the Gi-coupled signaling pathway.
Oxytocin signalling in human myometrium.
Oxytocin-stimulated insulin release in a clonal beta-cell line RINm5F: involvement of phospholipase C-dependent and -independent pathways.
Oxytocin-stimulated phosphoinositide hydrolysis in human myometrial cells: involvement of pertussis toxin-sensitive and -insensitive G-proteins.
P-selectin cross-links PSGL-1 and enhances neutrophil adhesion to fibrinogen and ICAM-1 in a Src kinase-dependent, but GPCR-independent mechanism.
P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice.
P0(106-125) is a neuritogenic epitope of the peripheral myelin protein P0 and induces autoimmune neuritis in C57BL/6 mice.
P2 purinergic agonists and 12-O-tetradecanoylphorbol-13-acetate, as well as protein kinase A activators, stimulate thyroglobulin secretion in FRTL-5 cells.
P2 purinoceptor stimulation attenuates PTH inhibition of phosphate uptake by a G protein-dependent mechanism.
P2 purinoceptor-mediated inhibition of cyclic AMP accumulation in NG108-15 cells.
P2 purinoceptors contribute to ATP-induced inhibition of L-type Ca2+ current in rabbit atrial myocytes.
P2 purinoceptors in cultured bovine middle cerebral artery endothelial cells.
P2 receptor-mediated inhibition of adenylyl cyclase in PC12 cells.
P2 Receptor-mediated Inhibition of Vasopressin-stimulated Fluid Transport and cAMP Responses in AQP2-transfected MDCK Cells.
P2-purigenic receptors regulate phospholipase C and adenylate cyclase activities in immortalized Schwann cells.
P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes.
P2-purinoceptor activation stimulates phosphoinositide hydrolysis and inhibits accumulation of cAMP in cultured ventricular myocytes.
P2-purinoceptor induced prostaglandin synthesis in primary rat astrocyte cultures.
P2-purinoceptor-mediated formation of inositol phosphates and intracellular Ca2+ transients in human coronary artery smooth muscle cells.
P2-purinoceptor-stimulated phosphoinositide turnover in chick myotubes. Calcium mobilization and the role of guanyl nucleotide-binding proteins.
P2U-purinergic receptor activation mediates inhibition of cAMP accumulation in cultured renal mesangial cells.
P2X receptor activation elicits transporter-mediated noradrenaline release from rat hippocampal slices.
P2X7 and P2Y13 purinergic receptors mediate intracellular calcium responses to BzATP in rat cerebellar astrocytes.
P2Y
P2Y purinergic receptor regulation of CFTR chloride channels in mouse cardiac myocytes.
P2Y purinoceptor activation mobilizes intracellular Ca2+ and induces a membrane current in rat intracardiac neurones.
P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells.
P2Y purinoceptors inhibit exocytosis in adrenal chromaffin cells via modulation of voltage-operated calcium channels.
P2Y receptor linked to phospholipase C: stimulation of neuro 2A cells by UTP and ATP and possible regulation by protein kinase C subtype epsilon.
P2Y receptor subtypes differentially couple to inwardly-rectifying potassium channels.
P2Y receptor-mediated Ca2+ signalling in cultured rat aortic smooth muscle cells.
P2Y receptor-mediated inhibition of tumor necrosis factor alpha -stimulated stress-activated protein kinase activity in EAhy926 endothelial cells.
P2Y receptor-mediated inhibition of voltage-activated Ca(2+) currents in PC12 cells.
P2Y receptors activate MAPK/ERK through a pathway involving PI3K/PDK1/PKC-zeta in human vein endothelial cells.
P2Y(13) receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells.
P2Y(2) receptor-mediated proliferation of C(6) glioma cells via activation of Ras/Raf/MEK/MAPK pathway.
P2Y-receptors mediating an inhibition of the evoked entry of calcium through N-type calcium channels at neuronal processes.
P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells.
P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B.
P2Y12 receptors in primary microglia activate nuclear factor of activated T-cell signaling to induce C-C chemokine 3 expression.
P2Y2 nucleotide receptors expressed heterologously in sympathetic neurons inhibit both N-type Ca2+ and M-type K+ currents.
P2Y5 is a G{alpha}i, G{alpha}12/13 G Protein Coupled Receptor Activated by Lysophosphatidic Acid that Reduces Intestinal Cell Adhesion.
p2y5/LPA6 attenuates LPA1-mediated VE-cadherin translocation and cell-cell dissociation through G12/13 protein-Src-Rap1.
p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta -adrenergic receptor-stimulated apoptosis. Evidence for Gi-dependent activation.
p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: use of pertussis toxin as a discrimination factor.
p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate.
PACAP and VIP stimulate Ca2+ oscillations in rat gonadotrophs through the PACAP/VIP type 1 receptor (PVR1) linked to a pertussis toxin-insensitive G-protein and the activation of phospholipase C-beta.
PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP.
PAF effects on transmembrane signaling pathways in rat Kupffer cells.
PAF receptors and G-proteins in human blood eosinophils and neutrophils.
Paired-pulse depression of the N-methyl-D-aspartate receptor-mediated synaptic potentials in the amygdala.
Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis.
Pancreastatin activates pertussis toxin-sensitive guanylate cyclase and pertussis toxin-insensitive phospholipase C in rat liver membranes.
Pancreastatin activates protein kinase C by stimulating the formation of 1,2-diacylglycerol in rat hepatocytes.
Pancreastatin increases free cytosolic Ca2+ in rat hepatocytes, involving both pertussis-toxin-sensitive and -insensitive mechanisms.
Pancreastatin inhibits insulin release from Rin m 5F cells: reversion by pertussis toxin.
Pancreastatin inhibits insulin secretion in RINm5F cells through obstruction of G-protein mediated, calcium-directed exocytosis.
Pancreastatin receptor is coupled to a guanosine triphosphate-binding protein of the G(q/11)alpha family in rat liver membranes.
Pancreastatin: a novel peptide inhibitor of parietal cell signal transduction.
Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells.
Pancreatic polypeptide inhibits calcium channels in rat sympathetic neurons via two signaling pathways.
Pancreatic polypeptide-fold peptide receptors and angiotensin II-induced renal vasoconstriction.
PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB, but not RANTES, IL-6, eotaxin or TARC expression in nasal epithelium.
PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology.
Paradoxes of pertussis toxin.
Paradoxical attenuation of {beta}2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase.
Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice.
Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor.
Parallel inactivation of Y2 receptor and G-proteins in CHO cells by pertussis toxin.
Parallel signaling pathways of melatonin in the pancreatic beta-cell.
Parapertussis and pertussis: differences and similarities in incidence, clinical course, and antibody responses.
Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells.
Parathyroid hormone increases cytosolic calcium concentration in adult rat cardiac myocytes.
Parathyroid hormone inhibits Na(+)-K(+)-ATPase through a cytochrome P-450 pathway.
Parathyroid hormone raises cytosolic calcium in pancreatic islets: study on mechanisms.
Parathyroid hormone-related protein inhibits indothelin-1 production.
Parathyroid hormone/adenylate cyclase coupling in vascular smooth muscle cells.
Parenteral immunization of mice with a genetically inactivated pertussis toxin DNA vaccine induces cell-mediated immunity and protection.
Parenteral medium-chain triglyceride-induced neutrophil activation is not mediated by a Pertussis Toxin sensitive receptor.
Parents as source of pertussis transmission in hospitalized young infants.
PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders.
Parstatin: a cryptic peptide involved in cardioprotection after ischemia and reperfusion injury.
Partial agonistic activity of naloxone on the opioid receptors expressed from complementary deoxyribonucleic acids in Chinese hamster ovary cells.
Partial characterization of GTP-binding proteins in Neurospora.
Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1.
Participation of cAMP in the facilitatory action of beta,gamma-methylene ATP on the noradrenaline release from rabbit ear artery.
Participation of G proteins in natriuretic peptide hormone secretion from heart atria.
Participation of membrane progesterone receptor ? in the inhibitory effect of progesterone on prolactin secretion.
Participation of pertussis toxin-sensitive GTP-binding regulatory proteins in the suppression of baroreceptor reflex by neurotensin in the rat.
Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation.
Parturition: activation of stimulatory pathways or loss of uterine quiescence?
Pasteurella (Mannheimia) haemolytica leukotoxin-induced cytolysis of bovine leukocytes: role of arachidonic acid and its regulation.
Pasteurella haemolytica A1-derived leukotoxin and endotoxin induce intracellular calcium elevation in bovine alveolar macrophages by different signaling pathways.
Pasteurella multocida toxin activates the inositol triphosphate signaling pathway in Xenopus oocytes via G(q)alpha-coupled phospholipase C-beta1.
Pasteurella multocida toxin as a tool for studying Gq signal transduction.
Pathogenesis and histopathology of pertussis: implications for immunization.
Pathways involved in PTH-induced rise in cytosolic Ca2+ concentration of rat renal proximal tubule.
Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors.
Pathways through which glucose induces a rise in [Ca2+]i of polymorphonuclear leukocytes of rats.
PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis.
PDGF-mediated activation of phosphatidylinositol 3 kinase in human mesangial cells.
PECAM-1 modulates thrombin-induced tissue factor expression on endothelial cells.
PEI6, a new basic secretagogue in rat peritoneal mast cells: characteristics of polyethylenimine PEI6 resemble those of compound 48/80.
Penetration of CD4 T cells by HIV-1. The CD4 receptor does not internalize with HIV, and CD4-related signal transduction events are not required for entry.
Peptide inhibitors of ADP-ribosylation by pertussis toxin are substrates with affinities comparable to those of the trimeric GTP-binding proteins.
Peptide mapping studies of the pertussis toxin substrate in human neutrophils, platelets and erythrocytes.
Peptide YY inhibition of rat gastric enterochromaffin-like cell function.
Peptide YY inhibits vasopressin-stimulated chloride secretion in inner medullary collecting duct cells.
Peptide YY receptors in the proximal tubule PKSV-PCT cell line derived from transgenic mice. Relation with cell growth.
Peptidergic modulation of G-protein coupled cyclic-AMP accumulation in the rat caudate nucleus.
Peptides from pertussis toxin interfere with neutrophil adherence in vitro and counteract inflammation in vivo.
Per- and Polyfluoroalkyl Substances Differentially Inhibit Placental Trophoblast Migration and Invasion In Vitro.
Performance of commercial enzyme-linked immunosorbent assays for the detection of antibodies to Bordetella pertussis.
Perinatal PTX-sensitive G-protein expression and regulation of conductive 22Na+ transport in lung apical membrane vesicles.
Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE.
Peripheral and central vascular smooth muscle cells from rat lung exhibit different cytoskeletal protein profiles but similar growth factor requirements.
Peripheral antinociceptive effect of pertussis toxin: activation of the arginine/NO/cGMP/PKG/ ATP-sensitive K channel pathway.
Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception.
Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat.
Peripheral non-opioid analgesic effects of kyotorphin in mice.
Peripheral pain is enhanced by insulin-like growth factor 1 through a G protein-mediated stimulation of T-type calcium channels.
Peripheral sensory neuron injury contributes to neuropathic pain in experimental autoimmune encephalomyelitis.
Permeabilization and calcium-dependent activation of rabbit polymorphonuclear leukocytes by poly-L-arginine.
Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP.
Permissive stimulation of Ca(2+)-induced phospholipase A2 by an adenosine receptor agonist in a pertussis toxin-sensitive manner in FRTL-5 thyroid cells: a new 'cross-talk' mechanism in Ca2+ signalling.
Persistence of Antibodies against Diphtheria, Tetanus, Pertussis, and Poliovirus Types I, II, and III Following Immunization with DTaP Combined with Inactivated Wild-Type Polio Vaccine (DTaP-wIPV).
Persistence of antibody after accelerated immunisation with diphtheria/tetanus/pertussis vaccine.
Persistence of T-cell immune response induced by two acellular pertussis vaccines in children five years after primary vaccination.
Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production.
Pertactin-deficient Bordetella pertussis isolates: evidence of increased circulation in Europe, 1998 to 2015.
Pertactin-negative Bordetella pertussis strains in Canada: characterization of a dozen isolates based on a survey of 224 samples collected in different parts of the country over the last 20 years.
Perturbation of regulated secretion in the pancreatic acinar cell line, AR42J.
Pertussis (whooping cough) toxin and Bordetella pertussis whole-cell antibody levels in a healthy New Zealand population.
Pertussis adjuvant prolongs intestinal hypersensitivity.
Pertussis and cholera toxin ADP-ribosylation in Dictyostelium discoideum membranes.
Pertussis and cholera toxins inhibit prostaglandin synthesis in rat astrocyte cultures at distinct metabolic steps.
Pertussis and cholera toxins modulate kappa-opioid receptor agonists-induced hypothermia and gut inhibition.
Pertussis antibodies in postpartum women and their newborns.
Pertussis antibodies, protection, and vaccine efficacy after household exposure.
Pertussis Antibody Concentrations in Infants Born Prematurely to Mothers Vaccinated in Pregnancy.
Pertussis antibody levels in infants and their mothers receiving combined tetanus-diphtheria toxoid and acellular pertussis vaccine during pregnancy in Turkey.
Pertussis Booster Vaccination in HIV-Infected Children Receiving Highly Active Antiretroviral Therapy.
Pertussis but not cholera toxin inhibits the stimulated increase in actin association with the cytoskeleton in rabbit neutrophils: role of the "G proteins" in stimulus-response coupling.
Pertussis encephalopathy in an adult: case report and review.
Pertussis encephalopathy with high cerebrospinal fluid antibody titers to pertussis toxin and filamentous hemagglutinin.
Pertussis holotoxoid formed in vitro with a genetically deactivated S1 subunit.
Pertussis IgE and atopic disease.
Pertussis immunization with acellular vaccines in Ghanaian children.
Pertussis in adults: possible use of booster doses for control.
Pertussis in infants less than 6 months of age and household contacts, Italy, April 2014.
Pertussis in infants, in their mothers and other contacts in Casablanca, Morocco.
Pertussis infection among adults during the 1993 outbreak in Chicago.
Pertussis infection in adults with persistent cough.
Pertussis is under diagnosed in infants hospitalized with lower respiratory tract infection in the pediatric intensive care unit.
Pertussis Leukocytosis: Mechanisms, Clinical Relevance and Treatment.
Pertussis of adults and infants.
Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines.
Pertussis resurgence: waning immunity and pathogen adaptation - two sides of the same coin.
Pertussis seroepidemiology in Taipei.
Pertussis seroepidemiology in women and their infants in Sarlahi District, Nepal.
Pertussis serology: assessment of IgG anti-PT ELISA for replacement of the CHO cell assay.
Pertussis Seronegativity in Pregnant Women in the City of Al Ain, United Arab Emirates.
Pertussis seroprevalence among adults of reproductive age (20-39 years) in fourteen European countries.
Pertussis seroprevalence in different age groups in Greece.
Pertussis seroprevalence in emergency department staff.
Pertussis serosurveillance study in izmir, Turkey.
Pertussis specific cell-mediated immune responses ten years after acellular pertussis booster vaccination in young adults.
Pertussis surveillance by small serosurveys of blood donors.
Pertussis toxin (IAP) enhances maitotoxin (a putative Ca2+ channel agonist)-induced Ca2+ entry into synaptosomes.
Pertussis toxin (PTX) B subunit and the nontoxic PTX mutant PT9K/129G inhibit Tat-induced TGF-beta production by NK cells and TGF-beta-mediated NK cell apoptosis.
Pertussis toxin abolishes angiotensin II-induced phosphoinositide hydrolysis and prostaglandin synthesis in rat renal mesangial cells.
Pertussis toxin abolishes mu- and delta-opioid agonist-induced place preference.
Pertussis toxin abolishes the antinociception mediated by opioid receptors in rat spinal cord.
Pertussis toxin abolishes the cardioprotective effect of ischemic preconditioning in intact rat heart.
Pertussis toxin abolishes the effect of neuropeptide Y on rat resistance arteriole contraction.
Pertussis toxin abolishes the inhibition of Ca2+ currents and of noradrenaline release via alpha 2-adrenoceptors in chick sympathetic neurons.
Pertussis toxin abolishes the inhibitory effects of prostaglandins E1, E2, I2 and F2 alpha on hormone-induced cAMP accumulation in cultured hepatocytes.
Pertussis toxin actions on the pituitary-derived 235-1 clone: effects of PGE1, cholera toxin, and forskolin on cyclic AMP metabolism and prolactin release.
Pertussis toxin activates adult and neonatal naive human CD4+ T lymphocytes.
Pertussis toxin activates L-arginine uptake in pulmonary endothelial cells through downregulation of PKC-alpha activity.
Pertussis toxin activates platelets through an interaction with platelet glycoprotein Ib.
Pertussis toxin activates protein kinase C and a tyrosine protein kinase in the human T cell line Jurkat.
Pertussis toxin activates tyrosine kinase signaling cascade in myelomonocytic cells: a mechanism for cell adhesion.
Pertussis toxin administered spinally induces a hypoglycemic effect on normal and diabetic mice.
Pertussis toxin administration increases the expression of proneurotensin and preproenkephalin A mRNAs in rat striatum.
Pertussis toxin alters the concentration and turnover of manganese superoxide dismutase in rat lung.
Pertussis toxin alters the growth characteristics of Swiss 3T3 cells.
Pertussis toxin alters the innate and the adaptive immune responses in a pertussis-dependent model of autoimmunity.
Pertussis Toxin Ameliorates Microglial Activation Associated With Ischemic Stroke.
Pertussis toxin analog with reduced enzymatic and biological activities is a protective immunogen.
Pertussis toxin and 4-aminopyridine differentially affect the hypnotic-anesthetic action of dexmedetomidine and pentobarbital.
Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract.
Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools.
Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis.
Pertussis toxin and H-7 distinguish mechanisms involved in eicosanoid release from lipopolysaccharide-primed macrophages. Eicosanoid release from lipopolysaccharide-primed macrophages.
Pertussis toxin and its binding unit inhibit HIV-1 infection of human cervical tissue and macrophages involving a CD14 pathway.
Pertussis toxin and lipopolysaccharide influence phagocytosis of Bordetella pertussis by human monocytes.
Pertussis toxin and N-ethylmaleimide inhibit histamine- but not calcium ionophore-induced endothelium-dependent relaxation.
Pertussis toxin and pre-junctional alpha 2-adrenoreceptors in rat heart and vas deferens.
Pertussis toxin and target eukaryotic cells: binding, entry, and activation.
Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathway.
Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neurons.
Pertussis toxin as a probe of neutrophil activation.
Pertussis toxin as an adjuvant suppresses the number and function of CD4(+)CD25(+) T regulatory cells.
Pertussis toxin attenuates 5-hydroxytryptamine1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes.
Pertussis toxin attenuates angiotensin II but not beta-adrenoceptor facilitation of noradrenaline release from rat kidney cortex.
Pertussis toxin attenuates angiotensin II-induced vasoconstriction and inhibition of renin release.
Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein.
Pertussis toxin attenuates clonidine inhibition of catecholamine release in adrenal chromaffin cells.
Pertussis toxin attenuates D2 inhibition and enhances D1 stimulation of adenylate cyclase by dopamine in rat striatum.
Pertussis toxin attenuates experimental autoimmune encephalomyelitis by upregulating neuronal vascular endothelial growth factor.
Pertussis toxin attenuates intracranial morphine self-administration.
Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs.
Pertussis toxin attenuates postsynaptic actions of neuropeptide Y on the guinea-pig uterine artery.
Pertussis toxin attenuates presynaptic inhibition of cholinergic but not nonadrenergic noncholinergic contraction in guinea pig airways.
Pertussis toxin augments beta-adrenergic relaxation of muscarinic contraction in canine trachealis.
Pertussis toxin B-oligomer dissociates T cell activation and HIV replication in CD4 T cells released from infected lymphoid tissue.
Pertussis toxin B-oligomer inhibits HIV infection and replication in hu-PBL-SCID mice.
Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C.
Pertussis toxin B-oligomer suppresses IL-6 induced HIV-1 and chemokine expression in chronically infected U1 cells via inhibition of activator protein 1.
Pertussis toxin B-pentamer mediates intercellular transfer of membrane proteins and lipids.
Pertussis toxin B-subunit-induced Ca2(+)-fluxes in Jurkat human lymphoma cells: the action of long-term pre-treatment with cholera and pertussis holotoxins.
Pertussis toxin blocks 5-HT1A and GABAB receptor-mediated inhibition of serotonergic neurons.
Pertussis toxin blocks a late inhibitory postsynaptic potential in hippocampal CA3 neurons.
Pertussis toxin blocks activin A-induced production of inositol phosphates in rat hepatocytes.
Pertussis toxin blocks adenosine A1 receptor mediated protection of the ischemic rat heart.
Pertussis toxin blocks an inhibition of hormone-stimulated glycogenolysis by prostaglandin E2 and its analogue in cultured hepatocytes.
Pertussis toxin blocks angiotensin II-induced calcium influx but not inositol trisphosphate production in adrenal glomerulosa cell.
Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra.
Pertussis toxin blocks both cyclic AMP-mediated and cyclic AMP-independent actions of somatostatin. Evidence for coupling of Ni to decreases in intracellular free calcium.
Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists on dorsal-horn network responses in spinal cord-ganglion cultures.
Pertussis toxin blocks M2 muscarinic receptor-mediated effects on contraction and cyclic AMP in the guinea pig ileum, but not M3-mediated contractions and phosphoinositide hydrolysis.
Pertussis toxin blocks melatonin-induced inhibition of forskolin-stimulated adenylate cyclase activity in the chick brain.
Pertussis toxin blocks melatonin-induced pigment aggregation in Xenopus dermal melanophores.
Pertussis toxin blocks presynaptic glutamate receptors--a novel 'glutamateB' receptor in the lobster neuromuscular synapse.
Pertussis toxin blocks somatostatin inhibition of calcium mobilization and reduces the affinity of somatostatin receptors for agonists.
Pertussis toxin blocks somatostatin's inhibition of stimulated cyclic AMP accumulation in anterior pituitary tumor cells.
Pertussis toxin blocks the action of morphine, norepinephrine and clonidine on isolated guinea-pig ileum.
Pertussis toxin blocks the dipsogenic actions of carbachol, but does not block the dipsogenic and pressor actions of angiotensin II.
Pertussis toxin blocks the effects of alpha 2-agonists and antagonists on locus coeruleus activity in vivo.
Pertussis toxin blocks the inhibitory effect of adenosine on rat cerebral cortical neurons.
Pertussis toxin blocks the inhibitory effect of muscarinic cholinergic agonists on cyclic AMP accumulation and prolactin secretion in GH3 anterior-pituitary tumour cells.
Pertussis toxin blocks the inhibitory effects of calcitonin on cyclic AMP accumulation in stimulated cultured human monocytes.
Pertussis toxin blocks the inhibitory effects of somatostatin on cAMP-dependent vasoactive intestinal peptide and cAMP-independent thyrotropin releasing hormone-stimulated prolactin secretion of GH3 cells.
Pertussis toxin blocks the outward currents evoked by opiate and alpha 2-agonists in locus coeruleus neurons.
Pertussis toxin blocks the somatostatin-induced inhibition of growth hormone release and adenosine 3',5'-monophosphate accumulation.
Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells.
Pertussis toxin can activate human platelets. Comparative effects of holotoxin and its ADP-ribosylating S1 subunit.
Pertussis toxin can distinguish the augmentary effect elicited by epidermal growth factor from that of phorbol ester on luteal adenylate cyclase activity.
Pertussis toxin can replace T cell receptor signals that induce positive selection of CD8 T cells.
Pertussis toxin catalyzed ADP-ribosylation of a 41 kDa G-protein impairs insulin-stimulated glucose metabolism in BC3H-1 myocytes.
Pertussis toxin catalyzes the ADP-ribosylation of two distinct peptides, 40 and 41 kDa, in rat fat cell membranes.
Pertussis toxin converts hyperpolarizations caused by alpha(2)-adrenoceptor agonists containing an imidazoline moiety into depolarizations in MIN 6 cells.
Pertussis toxin decreases absence seizures and GABA(B) receptor binding in thalamus of a genetically prone rat (GAERS).
Pertussis toxin decreases opiate receptor binding and adenylate inhibition in a neuroblastoma x glioma hybrid cell line.
Pertussis toxin differentially reduces the efficacy of opioids to produce supraspinal analgesia in the mouse.
Pertussis toxin differentiates between alpha 1- and alpha 2-adrenoceptor-mediated inhibition of noradrenaline release from rat kidney cortex.
Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors.
Pertussis toxin directly activates endothelial cell p42/p44 MAP kinases via a novel signaling pathway.
Pertussis toxin distinguishes between muscarinic receptor-mediated inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in Flow 9000 cells.
Pertussis toxin does not affect the adenosine-induced inhibition of the efferent function of cardiac capsaicin-sensitive nerves.
Pertussis toxin does not affect the time course of exocytosis in mast cells stimulated by intracellular application of GTP-gamma-S.
Pertussis toxin does not affect the time course of quantal release in crayfish and mouse muscle, but has other post- and presynaptic effects, especially on adenosine autoreceptors.
Pertussis toxin does not attenuate alpha 2-adrenoceptor mediated inhibition of noradrenaline release in mouse atria.
Pertussis toxin does not inhibit alpha 1-adrenergic potentiation of beta-adrenergic stimulation of cyclic AMP accumulation in rat pinealocytes.
Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization.
Pertussis toxin does not inhibit the alpha 1-adrenoceptor-mediated effect on inositol phosphate production in the heart.
Pertussis toxin does not prevent alpha adrenergic stimulated breakdown of phosphoinositides or respiration in brown adipocytes.
Pertussis toxin effects on adenylate cyclase activity, cyclic AMP accumulation and lipolysis in adipocytes from hypothyroid, euthyroid and hyperthyroid rats.
Pertussis toxin effects on chemoattractant-induced response heterogeneity in human PMNs utilizing Fluo-3 and flow cytometry.
Pertussis toxin effects on T lymphocytes are mediated through CD3 and not by pertussis toxin catalyzed modification of a G protein.
Pertussis toxin effects on transmitter release from perivascular nerve terminals.
Pertussis toxin enhanced IgG1 and IgE responses to primary tetanus immunization are mediated by interleukin-4 and persist during secondary responses to tetanus alone.
Pertussis toxin enhances colony organization of enzymatic-dissociated single human embryonic stem cells.
Pertussis toxin enhances fetal calf serum-induced alkaline phosphatase activity in osteoblast-like cells.
Pertussis toxin enhances follicle-stimulating hormone-stimulated cAMP production in rat seminiferous tubules in a stage-dependent manner.
Pertussis toxin enhances human immunodeficiency virus type 1 replication.
Pertussis toxin enhances proenkephalin synthesis in bovine chromaffin cells.
Pertussis toxin enhances Th1 responses by stimulation of dendritic cells.
Pertussis toxin enhances the beta-adrenergic and blocks the alpha 2-adrenergic regulation of renin secretion in renal cortical slices.
Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection.
Pertussis Toxin Exploits Host Cell Signaling Pathways Induced by Meningitis-Causing E. coli K1-RS218 and Enhances Adherence of Monocytic THP-1 Cells to Human Cerebral Endothelial Cells.
Pertussis Toxin Exploits Specific Host Cell Signaling Pathways for Promoting Invasion and Translocation of Escherichia coli K1 RS218 in Human Brain-derived Microvascular Endothelial Cells.
Pertussis toxin export genes are regulated by the ptx promoter and may be required for efficient translation of ptx mRNA in Bordetella pertussis.
Pertussis toxin export requires accessory genes located downstream from the pertussis toxin operon.
Pertussis toxin expression in Drosophila alters the visual response and blocks eating behaviour.
Pertussis toxin facilitates secretagogue-induced catecholamine release from cultured bovine adrenal chromaffin cells.
Pertussis toxin facilitates the progesterone-induced maturation of Xenopus oocyte. Possible role of protein phosphorylation.
Pertussis toxin from Bordetella pertussis blocks neutrophil migration and neutrophil-dependent edema in response to inflammation.
Pertussis toxin gene: nucleotide sequence and genetic organization.
Pertussis toxin has eukaryotic-like carbohydrate recognition domains.
Pertussis toxin IgA testing over-diagnoses recent pertussis infection.
Pertussis toxin improves immune responses to a combined pneumococcal antigen and leads to enhanced protection against Streptococcus pneumoniae.
Pertussis toxin in the A10 region increases dopamine synthesis and metabolism.
Pertussis toxin in the analysis of receptor mechanisms.
Pertussis toxin inactivates the presynaptic serotonin autoreceptor in the hippocampus.
Pertussis toxin increases isoproterenol induced relaxation in field-stimulated ileum.
Pertussis toxin increases sensitivity to the lethal effect of morphine in mice.
Pertussis toxin induces angiogenesis in brain microvascular endothelial cells.
Pertussis toxin induces bronchopulmonary hyperresponsiveness in guinea-pigs while antagonizing the effects of formyl-L-methionyl-L-leucyl-L-phenylalanine.
Pertussis toxin induces fatty liver, hyperlipemia and ketosis in hamsters.
Pertussis toxin induces lymphocytosis in rhesus macaques.
Pertussis toxin induces parallel loss of neuropeptide Y Y1 receptor dimers and Gi alpha subunit function in CHO cells.
Pertussis toxin induces structural changes in G alpha proteins independently of ADP-ribosylation.
Pertussis toxin inhibition of alpha 1-adrenergic or vasopressin-induced Ca2+ fluxes in rat liver. Selective inhibition of the alpha 1-adrenergic receptor-coupled metabolic activation.
Pertussis toxin inhibition of anti-immunoglobulin-stimulated proliferation and inositol phosphate formation.
Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide.
Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.
Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a membrane protein in a human-mouse hybrid cell line.
Pertussis toxin inhibition of T-cell hybridoma invasion is reversed by manganese-induced activation of LFA-1.
Pertussis toxin inhibits 1-methyladenine-induced maturation in starfish oocytes.
Pertussis toxin inhibits activation-induced cell death of human thymocytes, pre-B leukemia cells and monocytes.
Pertussis toxin inhibits alpha 2-adrenoceptor-mediated inhibition of adenylate cyclase without affecting muscarinic regulation of [Ca2+]i or inositol phosphate generation in SH-SY5Y human neuroblastoma cells.
Pertussis toxin inhibits angiotensin II-mediated phosphatidylinositol breakdown and ADP-ribosylates a 40 Kd protein in cultured smooth muscle cells.
Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen.
Pertussis toxin inhibits autophosphorylation and activation of the insulin receptor kinase.
Pertussis toxin inhibits cAMP surface receptor-stimulated binding of [35S]GTP gamma S to Dictyostelium discoideum membranes.
Pertussis toxin inhibits cAMP-induced desensitization of adenylate cyclase in Dictyostelium discoideum.
Pertussis toxin inhibits chemotactic factor-induced phospholipase C stimulation and lysosomal enzyme secretion in rabbit neutrophils.
Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells.
Pertussis toxin inhibits cholecystokinin- and epidermal growth factor-induced mitogen-activated protein kinase activation by disinhibition of the cAMP signaling pathway and inhibition of c-Raf-1.
Pertussis toxin inhibits contractions but not endothelium-dependent relaxations of rabbit pulmonary artery in response to acetylcholine and other agonists.
Pertussis toxin inhibits differentiation induced by retinoic acid in a human promyelocytic leukemia cell line HL-60.
Pertussis toxin inhibits early chemokine production to delay neutrophil recruitment in response to Bordetella pertussis respiratory tract infection in mice.
Pertussis toxin inhibits EGF-, phorbol ester- and insulin-stimulated DNA synthesis in BALB/c3T3 cells: evidence for post-receptor activation of Gi alpha.
Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE.
Pertussis toxin inhibits endothelium-dependent relaxations evoked by fluoride.
Pertussis toxin inhibits endothelium-dependent relaxations to certain agonists in porcine coronary arteries.
Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cells.
Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.
Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones.
Pertussis toxin inhibits human neutrophil responses mediated by the 42-kilodalton IgG Fc receptor.
Pertussis toxin inhibits induction of human immunodeficiency virus type 1 in infected monocytes.
Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals.
Pertussis toxin inhibits intracellular pH changes in human neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine.
Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords.
Pertussis toxin inhibits morphine analgesia and prevents opiate dependence.
Pertussis toxin inhibits morphine-induced release of adenosine from the spinal cord.
Pertussis toxin inhibits negative inotropic and negative chronotropic muscarinic cholinergic effects on the heart.
Pertussis toxin inhibits neuropeptide Y-induced feeding in rats.
Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis.
Pertussis toxin inhibits noradrenaline accumulation by bovine adrenal medullary chromaffin cells.
Pertussis toxin inhibits norepinephrine-stimulated inositol phosphate formation in primary brain cell cultures.
Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids.
Pertussis toxin inhibits retinoic acid-induced expression of tissue transglutaminase in macrophages.
Pertussis toxin inhibits signal transduction at a specific metabolotropic glutamate receptor in primary cultures of cerebellar granule cells.
Pertussis toxin inhibits somatostatin-induced K+ conductance in human pituitary tumor cells.
Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells.
Pertussis toxin inhibits the action of insulin-like growth factor-I.
Pertussis toxin inhibits the angiotensin II and serotonin-induced rise of free cytoplasmic calcium in cultured smooth muscle cells from rat aorta.
Pertussis toxin inhibits the antinociceptive action of morphine in the rat.
Pertussis toxin inhibits the behavioural and ECoG effects induced by clonidine and yohimbine after their microinfusion into the locus coeruleus.
Pertussis toxin inhibits the FMLP-induced membrane association of protein kinase C in human neutrophils.
Pertussis toxin inhibits the rise in the intracellular concentration of free calcium that is induced by chemotactic factors in rabbit neutrophils: possible role of the "G proteins" in calcium mobilization.
Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts.
Pertussis toxin interferes with superantigen-induced deletion of peripheral T cells without affecting T cell activation in vivo. Inhibition of deletion and associated programmed cell death depends on ADP-ribosyltransferase activity.
Pertussis Toxin Is a Robust and Selective Inhibitor of High Grade Glioma Cell Migration and Invasion.
Pertussis toxin is required for pertussis vaccine encephalopathy.
Pertussis toxin is superior to TLR ligands in enhancing pathogenic autoimmunity, targeted at a neo-self antigen, by triggering robust expansion of Th1 cells and their cytokine production.
Pertussis toxin lesioning of the nucleus caudate-putamen attenuates adenylate cyclase inhibition and alters neuronal electrophysiological activity.
Pertussis toxin lesions of the rat substantia nigra block the inhibitory effects of the gamma-hydroxybutyrate agent, S(-)HA-966 without affecting the basal firing properties of dopamine neurons.
Pertussis toxin mediates ADP-ribosylation of pituitary membrane proteins.
Pertussis toxin modification of PC12 cells inhibits a protein phosphatase 2A-like phosphatase.
Pertussis toxin modification of PC12 cells lowers cytoskeletal F-actin and enhances norepinephrine secretion: involvement of protein kinase C and protein phosphatases.
Pertussis toxin modifies the characteristics of both the inhibitory GTP binding proteins and the somatostatin receptor in anterior pituitary tumor cells.
Pertussis toxin modifies the effect of central morphine on rat intestinal motility.
Pertussis toxin modulates dopamine inhibition of Na,K-ATPase activity in rat proximal convoluted tubule segments.
Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis.
Pertussis toxin modulates the immune response to neuroantigens injected in incomplete Freund's adjuvant: induction of Th1 cells and experimental autoimmune encephalomyelitis in the presence of high frequencies of Th2 cells.
Pertussis toxin non-sensitive G protein mediates cholinergic stimulation for secretion of pancreastatin and somatostatin from QGP-1N cells.
Pertussis toxin normalizes enhanced renovascular responses to angiotensin II in spontaneously hypertensive rats.
Pertussis Toxin Nullifies the Depolarization of the Membrane Potential and the Stimulation of the Rapid Phase of Ca Entry Through L-type Calcium Channels that are Produced by Follicle Stimulating Hormone in 10- to 12-Day-Old Rat Sertoli Cells.
Pertussis toxin or 8-bromo-cAMP block inhibition of the acoustic startle response by the alpha 2-adrenergic agonist ST-91.
Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes.
Pertussis toxin partially inhibits phagocytosis of immunoglobulin G-opsonized Staphylococcus aureus by human granulocytes but does not affect intracellular killing.
Pertussis toxin permeabilization enhances the traversal of Escherichia coli K1, macrophages, and monocytes in a cerebral endothelial barrier model in vitro.
Pertussis toxin plays an early role in respiratory tract colonization by Bordetella pertussis.
Pertussis toxin potentiates anesthesia-induced renin secretion.
Pertussis toxin potentiates seizures induced by pilocarpine, kainic acid and N-methyl-D-aspartate.
Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28.
Pertussis toxin pretreatment abolishes dihydropyridine inhibition of calcium flux in the 235-1 pituitary cell line.
Pertussis toxin pretreatment abolishes the inhibitory effect of riluzole and carbachol on D-[3H]aspartate release from cultured cerebellar granule cells.
Pertussis toxin pretreatment affects opiate/nonopiate and stress-induced analgesia differently.
Pertussis toxin pretreatment alters agonist binding to beta-adrenoceptors in rabbit ventricular myocardium.
Pertussis toxin pretreatment alters the in vivo cell division behaviour and survival of B lymphocytes after intravenous transfer.
Pertussis toxin pretreatment antagonizes the actions of mu- and delta-opiate agonists in hippocampal slices.
Pertussis toxin pretreatment discriminates between pre- and postsynaptic actions of baclofen in rat dorsal raphe nucleus in vitro.
Pertussis toxin pretreatment enhances catecholamine secretion induced by pituitary adenylate cyclase-activating polypeptide in cultured porcine adrenal medullary chromaffin cells: a possible role of the inositol lipid cascade.
Pertussis toxin pretreatment reveals differential effects of adenosine analogs on IgE-dependent histamine and peptidoleukotriene release from RBL-2H3 cells.
Pertussis toxin prevents adenosine receptor- and m-cholinoceptor-mediated sinus rate slowing and AV conduction block in the guinea-pig heart.
Pertussis toxin prevents homologous desensitization of adenylate cyclase in cultured renal epithelial cells.
Pertussis toxin prevents induction of hippocampal long-term potentiation in the stratum radiatum and stratum oriens inputs to CA1 neurons.
Pertussis toxin prevents neomycin-induced calcium-dependent electrophysiological effects in rat hippocampal slices.
Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [(3)H]GABA release.
Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein.
Pertussis toxin prevents the inhibitory effect of adenosine and unmasks adenosine-induced excitation of mammalian motor nerve endings.
Pertussis toxin produces differential inhibitory effects on basal, P2-purinergic, and chemotactic peptide-stimulated inositol phospholipid breakdown in HL-60 cells and HL-60 cell membranes.
Pertussis toxin promoter sequences involved in modulation.
Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway.
Pertussis toxin promotes pulmonary hypertension in an infant mouse model of Bordetella pertussis infection.
Pertussis toxin promotes relapsing-remitting experimental autoimmune encephalomyelitis in Lewis rats.
Pertussis toxin provides evidence for two independent signalling pathways leading to the activation of the nerve growth factor gene.
Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model.
Pertussis toxin reduces endothelium-dependent and independent responses to alpha-2- adrenergic stimulation in systemic canine arteries and veins.
Pertussis toxin reduces the antiadrenergic effect of 2-chloroadenosine on papillary muscle and the direct negative inotropic effect of 2-chloroadenosine on atrium.
Pertussis toxin reduces the day-night rhythm of nociception and mu and kappa opioid peptide-mediated antinociception in the snail, Cepaea nemoralis.
Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells.
Pertussis toxin relaxes small arteries with no vascular lesions or vascular smooth muscle cell injury.
Pertussis toxin reversal of the antilipolytic action of insulin in rat adipocytes in the presence of forskolin does not involve cyclic AMP.
Pertussis toxin reverses adenosine inhibition of neuronal glutamate release.
Pertussis toxin reverses adenosine receptor-mediated inhibition of renin secretion in rat renal cortical slices.
Pertussis toxin reverses Gpp(NH)p inhibition of basal and forskolin activated adipocyte adenylate cyclase.
Pertussis toxin reverses prostaglandin E2- and somatostatin-induced inhibition of rat parietal cell H(+)-production.
Pertussis toxin reverses the inhibition of insulin secretion caused by [Arg8]vasopressin in rat pancreatic islets.
Pertussis toxin reverses the inhibition of the adenylyl cyclase system by khellin in HeLa cells.
Pertussis toxin S1 mutant with reduced enzyme activity and a conserved protective epitope.
Pertussis toxin selectively abolishes hormone induced lowering of cytosolic calcium in GH3 cells.
Pertussis toxin selectively interferes with the responses of the HL-60 human promyelocytic cell line to dimethylsulfoxide.
Pertussis toxin sensitive and insensitive effects of adenosine and carbachol in murine atria overexpressing A(1)-adenosine receptors.
Pertussis toxin sensitive effects of dipyridamole on rat atrial rate.
Pertussis toxin sensitive endothelin-1 coupling to inositol phosphate formation via a GTP-binding protein: comparison in SHR and WKY cultured aortic smooth muscle cells.
Pertussis toxin sensitive G-protein coupling of HDL receptor to phospholipase C in human platelets.
Pertussis toxin sensitive G-proteins are not involved in the mitogenic signaling pathway of insulin-like growth factor-I in normal rat kidney epithelial (NRKE) cells.
Pertussis toxin sensitive photoaggregation of pigment in isolated Xenopus tail-fin melanophores.
Pertussis toxin sensitivity of drug-induced potentials on the rat superior cervical ganglion.
Pertussis toxin sensitization alters the pathogenesis of subsequent respiratory syncytial virus infection.
Pertussis toxin separates two muscarinic receptor-effector mechanisms in the striatum.
Pertussis toxin shows distinct early signalling events in platelet-activating factor-, leukotriene B4-, and C5a-induced eosinophil homotypic aggregation in vitro and recruitment in vivo.
Pertussis toxin signals through the TCR to initiate cross-desensitization of the chemokine receptor CXCR4.
Pertussis toxin specifically inhibits growth cone guidance by a mechanism independent of direct G protein inactivation.
Pertussis toxin stimulates cholecystokinin-induced cyclic AMP formation but is without effect on secretagogue-induced calcium mobilization in exocrine pancreas.
Pertussis toxin stimulates delayed-onset, Ca2+-dependent catecholamine release and the ADP-ribosylation of a 40 kDa protein in bovine adrenal chromaffin cells.
Pertussis toxin stimulates hypersensitivity and enhances nerve-mediated antigen uptake in rat intestine.
Pertussis toxin stimulates IL-17 production in response to Bordetella pertussis infection in mice.
Pertussis toxin stimulates the secretion of [Met5]-enkephalin and the expression of proenkephalin A mRNA in bovine adrenal medullary chromaffin cells.
Pertussis toxin stimulation of catecholamine release from adrenal medullary chromaffin cells: mechanism may be by direct activation of L-type and G-type calcium channels.
Pertussis toxin substrate is a guanosine 5'-[beta-thio]diphosphate-, N-ethylmaleimide-, Mg2+- and temperature-sensitive GTP-binding protein.
Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.
Pertussis toxin suppresses carbachol-evoked cardiodepression but does not modify cardiostimulation mediated through beta1- and putative beta4-adrenoceptors in mouse left atria: no evidence for beta2- and beta3-adrenoreceptor function.
Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses.
Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract.
Pertussis toxin targets the innate immunity through DAP12, FcR?, and MyD88 adaptor proteins.
Pertussis toxin transiently affects barrier integrity, organelle organization and transmigration of monocytes in a human brain microvascular endothelial cell barrier model.
Pertussis toxin treatment alters manganese superoxide dismutase activity in lung. Evidence for lung oxygen toxicity in air-breathing rats.
Pertussis toxin treatment attenuates some effects of insulin in BC3H-1 murine myocytes.
Pertussis toxin treatment blocks hyperpolarization by muscarinic agonists in chick atrium.
Pertussis toxin treatment blocks the inhibition of somatostatin and increases the stimulation by forskolin of cyclic AMP accumulation and adrenocorticotropin secretion from mouse anterior pituitary tumor cells.
Pertussis toxin treatment counteracts intramembrane interactions between neuropeptide Y receptors and alpha 2-adrenoceptors.
Pertussis toxin treatment counteracts the cardiovascular effects of neuropeptide Y and clonidine in the awake unrestrained rat.
Pertussis toxin treatment differentially affects cholinergic and dopaminergic receptor stimulation of midbrain dopaminergic neurons.
Pertussis toxin treatment does not inhibit the effects of the potassium channel opener BRL 34915 on rat isolated vascular and cardiac tissues.
Pertussis toxin treatment in vivo is associated with a decline in G-protein beta-subunits.
Pertussis toxin treatment in vivo reduces surface expression of the adhesion integrin leukocyte function antigen-1 (LFA-1).
Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons.
Pertussis toxin treatment modifies opiate action in the rat brain striatum.
Pertussis toxin treatment of whole blood. A novel approach to assess G protein function in congestive heart failure.
Pertussis toxin treatment prevents 5-HT(5a) receptor-mediated inhibition of cyclic AMP accumulation in rat C6 glioma cells.
Pertussis toxin treatment results in tolerance to the depressant effects of opioid, monoaminergic, and muscarinic agonists on dorsal-horn network responses in mouse spinal cord-ganglion cultures.
Pertussis toxin triggers rapid second messenger production in human T lymphocytes.
Pertussis toxin uncouples dopamine agonist inhibition of prolactin release.
Pertussis toxin unmasks stimulatory myocardial A2-adenosine receptors on ventricular cardiomyocytes.
Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation.
Pertussis toxin utilizes proximal components of the T-cell receptor complex to initiate signal transduction events in T cells.
Pertussis Toxin, an Inhibitor of G(?i) PCR, Inhibits Bile Acid- and Cytokine-Induced Apoptosis in Primary Rat Hepatocytes.
Pertussis toxin, but not tyrosine kinase inhibitors, abolishes effects of U-50488H on [Ca2+]i in myocytes.
Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism.
Pertussis toxin-catalysed ADP-ribosylation of endometrial proteins in sheep.
Pertussis toxin-catalyzed ADP-ribosylation of a G protein in mouse oocytes, eggs, and preimplantation embryos: developmental changes and possible functional roles.
Pertussis toxin-catalyzed ADP-ribosylation of adenylate cyclase. Effects of guanyl nucleotides and rhodopsin.
Pertussis toxin-catalyzed ADP-ribosylation of G(o) alpha with mutations at the carboxyl terminus.
Pertussis toxin-catalyzed ADP-ribosylation of Gi-2 and Gi-3 in CHO cells is modulated by inhibitors of intracellular trafficking.
Pertussis toxin-catalyzed ADP-ribosylation of GTP-binding proteins with digoxigenin-conjugated NAD. Identification of the proteins in plasma membranes and nuclei.
Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site.
Pertussis toxin-catalyzed ADP-ribosylation: effects on the coupling of inhibitory receptors to the adenylate cyclase system.
Pertussis toxin-dependent and -independent hormonal effects on cultured renal epithelioid cells.
Pertussis toxin-induced ADP ribosylation of inhibitor G proteins alters vagal control of heart rate in vivo.
Pertussis toxin-induced alterations of murine hepatic drug metabolism following administration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed.
Pertussis toxin-induced cytokine differentiation and clonal expansion of T cells is mediated predominantly via costimulation.
Pertussis toxin-induced histamine sensitisation: an aspecific phenomenon independent from the nitric oxide system?
Pertussis toxin-induced hyperacute autoimmune encephalomyelitis in Lewis rats is correlated with increased expression of inducible nitric oxide synthase and tumor necrosis factor alpha.
Pertussis toxin-induced inflammatory response exacerbates intracerebral haemorrhage and ischaemic stroke in mice.
Pertussis toxin-induced lung edema. Role of manganese superoxide dismutase and protein kinase C.
Pertussis toxin-induced lymphocytosis is associated with alterations in thymocyte subpopulations.
Pertussis toxin-induced mitogenesis in human T lymphocytes.
Pertussis toxin-induced redistribution of cortical actomyosin and inhibition of phagocytosis in rat Kupffer cells.
Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice.
Pertussis toxin-insensitive activation of the heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein activator.
Pertussis toxin-insensitive effects of mastoparan, a wasp venom peptide, in PC12 cells.
Pertussis toxin-insensitive G protein mediates substance P-induced inhibition of potassium channels in brain neurons.
Pertussis toxin-insensitive phosphoinositide hydrolysis, membrane depolarization, and positive inotropic effect of carbachol in chick atria.
Pertussis toxin-insensitive regulation of phosphatidylinositol hydrolysis by vanadate in brain microvessels.
Pertussis toxin-insensitive signaling of the ORL1 receptor: coupling to Gz and G16 proteins.
Pertussis toxin-mediated ADP-ribosylation of rabbit luteal Gi uncouples enkephalin inhibition of adenylyl cyclase.
Pertussis toxin-mediated ADP-ribosylation of target proteins in Chinese hamster ovary cells involves a vesicle trafficking mechanism.
Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.
Pertussis toxin-sensitive activation of phospholipase A2 can be resolved from phosphoinositidase C in primary cultures of mouse osteoblasts using indomethacin.
Pertussis toxin-sensitive activation of phospholipase C by the C5a and fMet-Leu-Phe receptors.
Pertussis toxin-sensitive airway beta-adrenergic dysfunction by somatostatin.
Pertussis toxin-sensitive and -insensitive mechanisms for diacylglycerol-protein kinase C signalling during insulin action in BC3H-1 myocytes.
Pertussis toxin-sensitive and -insensitive mechanisms of alpha1-adrenoceptor-mediated inotropic responses in rat heart.
Pertussis toxin-sensitive and -insensitive thrombin stimulation of Shc phosphorylation and mitogenesis are mediated through distinct pathways.
Pertussis toxin-sensitive and insensitive intracellular signalling pathways in undifferentiated 3T3-L1 cells stimulated by insulin converge with phosphatidylinositol 3-kinase upstream of the Ras mitogen-activated protein kinase cascade.
Pertussis toxin-sensitive and pertussis toxin-insensitive inhibition of parietal cell response to GLP-1 and histamine.
Pertussis toxin-sensitive cholinergic inhibition of somatostatin release from canine D-cells.
Pertussis toxin-sensitive factor differentially regulates lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production in mouse peritoneal macrophages.
Pertussis toxin-sensitive G protein alpha-subunits: production of monoclonal antibodies and detection of differential increases on differentiation of PC12 and LA-N-5 cells.
Pertussis toxin-sensitive G protein but not NO/cGMP pathway mediates the negative inotropic effect of carbachol in adult rat cardiomyocytes.
Pertussis toxin-sensitive G protein mediates coronary microvascular control during autoregulation and ischemia in canine heart.
Pertussis toxin-sensitive G protein mediation of PGE2 inhibition of cAMP metabolism and phasic glucose-induced insulin secretion in HIT cells.
Pertussis toxin-sensitive G protein modulates the ability of histamine to stimulate cAMP production in the chick pineal gland.
Pertussis toxin-sensitive G protein that supports vitellogenin uptake by promoting patency.
Pertussis toxin-sensitive G proteins as mediators of stretch-induced decrease in nitric-oxide release of osteoblast-like cells.
Pertussis toxin-sensitive G proteins as mediators of the signal transduction pathways activated by cytomegalovirus infection of smooth muscle cells.
Pertussis toxin-sensitive G proteins in regenerated endothelial cells of porcine coronary artery.
Pertussis toxin-sensitive G proteins influence nitric oxide synthase III activity and protein levels in rat heart.
Pertussis toxin-sensitive G proteins mediate carbachol-induced REM sleep and respiratory depression.
Pertussis toxin-sensitive G proteins mediate the inhibition of basal phosphoinositide metabolism caused by adenosine A1 receptors in rat hippocampal slices.
Pertussis toxin-sensitive G(i)-proteins and intracellular calcium sensitivity of vasoconstriction in the intact rat tail artery.
Pertussis toxin-sensitive G-protein activation does not influence the response to Bay K 8644 in embryonic chick myocytes.
Pertussis toxin-sensitive G-protein and protein kinase C activity are involved in normal synapse elimination in the neonatal rat muscle.
Pertussis toxin-sensitive G-protein mediates galanin's inhibition of scopolamine-evoked acetylcholine release in vivo and carbachol-stimulated phosphoinositide turnover in rat ventral hippocampus.
Pertussis toxin-sensitive G-proteins and regulation of blood pressure in the spontaneously hypertensive rat.
Pertussis toxin-sensitive G-proteins are not involved in activation of T-lymphocytes.
Pertussis toxin-sensitive G-proteins in the sino-atrial node and right atrium of bovine heart.
Pertussis toxin-sensitive G-proteins inhibit fibroblast growth factor-induced signaling in pancreatic acini.
Pertussis toxin-sensitive G-proteins regulate lymphoid lineage specification in multipotent hematopoietic progenitors.
Pertussis toxin-sensitive Galphai protein and ERK-dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts.
Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes.
Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells.
Pertussis toxin-sensitive GTP-binding proteins characterized in synaptosomal fractions of embryonic avian cerebral cortex.
Pertussis toxin-sensitive GTP-binding proteins may regulate phospholipase A2 in response to thrombin in rabbit platelets.
Pertussis toxin-sensitive GTP-binding proteins regulate activation-induced apoptotic cell death of human natural killer cells.
Pertussis toxin-sensitive heterotrimeric G?i/o proteins mediate WNT/?-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A.
Pertussis toxin-sensitive inhibition of glucagon-like peptide 1-stimulated acid production by epidermal growth factor and transforming growth factor alpha in rat parietal cells.
Pertussis toxin-sensitive melatonin receptors negatively coupled to adenylate cyclase associated with cultured human and rat retinal pigment epithelial cells.
Pertussis toxin-sensitive modulation of glutamate transport by endothelin-1 type A receptors in glioma cells.
Pertussis toxin-sensitive muscarinic relaxation in the rat iris dilator muscle.
Pertussis toxin-sensitive pathway in the stimulation of c-myc expression and DNA synthesis by bombesin.
Pertussis toxin-sensitive pathway inhibits glucose-stimulated Ca2+ signals of rat islet beta-cells by affecting L-type Ca2+ channels and voltage-dependent K+ channels.
Pertussis toxin-sensitive secretory phospholipase A2 expression and motility in activated primary human keratinocytes.
Pertussis toxin-sensitive signal controls the trafficking of thymocytes across the corticomedullary junction in the thymus.
Pertussis toxin-treated dog: a whole animal model of impaired inhibitory regulation of adenylate cyclase.
Pertussis toxin. Affinity purification of a new ADP-ribosyltransferase.
Pertussis toxin. Entry into cells and enzymatic activity.
Pertussis Toxin: A Key Component in Pertussis Vaccines?
Pertussis toxin: a tool for studying the regulation of adenylate cyclase.
Pertussis toxin: lessons from biological and biochemical effects in different cells.
Pertussis toxin: the cause of the harmful effects and prolonged immunity of whooping cough. A hypothesis.
Pertussis toxin: transition state analysis for ADP-ribosylation of G-protein peptide alphai3C20.
Pertussis vaccination during pregnancy in Belgium: Follow-up of infants until 1 month after the fourth infant pertussis vaccination at 15 months of age.
Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study.
Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy.
Pertussis vaccine and pertussis toxin increase lithium levels in rats: possible role of G-proteins.
Pertussis vaccine: a critique.
Pertussis whole cell vaccine: relation between intracerebral protection in mice and antibody response to pertussis toxin, filamentous hemagglutinin and adenylate cyclase.
Pertussis-specific cell-mediated immunity in infants after vaccination with a tricomponent acellular pertussis vaccine.
Pertussis-toxin insensitive enkephalin inhibition of adenylyl cyclase in lacrimal acinar cells.
Pertussis-toxin-sensitive inhibition by (-) baclofen of Ca signals in bovine chromaffin cells.
Pertussis: an important target for maternal immunization.
Pertussis: current concepts of pathogenesis and prevention.
PGE2 increases the tetrodotoxin-resistant Nav1.9 sodium current in mouse DRG neurons via G-proteins.
PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosis.
PGE2 regulates cAMP production in cultured rabbit CCD cells: evidence for dual inhibitory mechanisms.
PGE2 reverses AVP inhibition of HCO3- absorption in rat MTAL by activation of protein kinase C.
PGE2-induced inhibition of AVP-dependent cAMP accumulation in the OMCD of the rat kidney is cumulative with respect to the effects of alpha 2-adrenergic and alpha 1-adenosine agonists, insensitive to pertussis toxin and dependent on extracellular calcium.
PGF2alpha-induced signaling events in glomerular mesangial cells.
Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation.
Pharmacologic control of histamine release from human basophils induced by platelet-activating factor.
Pharmacologic evidence for 5-HT1A receptors associated with human retinal pigment epithelial cells in culture.
Pharmacologic regulation of histamine release by the human recombinant histamine-releasing factor.
Pharmacologic reversal of pertussis toxin-induced thermal allodynia in mice.
Pharmacological actions of AH-9700 on micturition reflex in anesthetized rats.
Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes.
Pharmacological analysis of signal transduction pathways required for oxidative burst in chicken heterophils stimulated by a Toll-like receptor 2 agonist.
Pharmacological analysis of the contractile role of M2 and M3 muscarinic receptors in smooth muscle.
Pharmacological and biochemical characterization of dopamine receptors mediating stimulation of a high affinity GTPase in rat striatum.
Pharmacological and functional characterization of bradykinin receptors in rat cultured vascular smooth muscle cells.
Pharmacological and functional characterization of D2, D3 and D4 dopamine receptors in fibroblast and dopaminergic cell lines.
Pharmacological and functional characterization of muscarinic receptors in the frog pars intermedia.
Pharmacological and immunocytochemical characterization of metabotropic glutamate receptors in cultured Purkinje cells.
Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema.
Pharmacological and molecular evidence for dopamine D(1) receptor expression by striatal astrocytes in culture.
Pharmacological and signaling properties of endogenous P2Y1 receptors in cystic fibrosis transmembrane conductance regulator-expressing Chinese hamster ovary cells.
Pharmacological characterisation of melatonin mt1 receptor-mediated stimulation of [35S]-GTPgammaS binding.
Pharmacological characterisation of the goldfish somatostatin sst5 receptor.
Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia.
Pharmacological characterization of a UTP-sensitive P2Y nucleotide receptor in organ cultured coronary arteries.
Pharmacological characterization of A2-adenosine receptors in guinea-pig ventricular cardiomyocytes.
Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells.
Pharmacological characterization of alpha 2-adrenoceptor regulated serotonin release in the rat hippocampus.
Pharmacological characterization of alpha 2-adrenoceptors in isolated jejunum of rabbits.
Pharmacological characterization of endothelin-stimulated phosphoinositide breakdown and cytosolic free Ca2+ rise in rat C6 glioma cells.
Pharmacological characterization of extracellular acidification rate responses in human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells.
Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors.
Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes.
Pharmacological characterization of muscarinic receptors mediating inhibition of adenylate cyclase activity in the rat retina.
Pharmacological characterization of muscarinic responses in rat hippocampal pyramidal cells.
Pharmacological characterization of phosphoinositide-linked glutamate receptor excitation of hippocampal neurons.
Pharmacological characterization of rat retinal dopamine receptors.
Pharmacological characterization of regulation of phosphoinositide metabolism by recombinant 5-HT2 receptors of the rat.
Pharmacological characterization of the "silent" 5-hydroxytryptamine1B-like receptors of rabbit ear artery.
Pharmacological characterization of the adenylate cyclase-coupled adenosine receptor in isolated guinea pig atrial myocytes.
Pharmacological characterization of the contractile effects of galanin (1-29)-NH2, galantide and galanin (1-14)-(alpha-aminobutyric acid8)scyliorhinin-I in the rat gastric fundus.
Pharmacological characterization of the human P2Y4 receptor.
Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells.
Pharmacological characterization of type 1alpha metabotropic glutamate receptor-stimulated [35S]-GTPgammaS binding.
Pharmacological comparison of UTP- and thapsigargin-induced arachidonic acid release in mouse RAW 264.7 macrophages.
Pharmacological control of human basophil histamine release stimulated by eosinophil granule major basic protein.
Pharmacological Cyclophilin Inhibitors Prevent Intoxication of Mammalian Cells with Bordetella pertussis Toxin.
Pharmacological differentiation by pertussis toxin of the in vivo acute responses to fMLP and PAF in guinea-pig lungs.
Pharmacological differentiation of angiotensin effects in the rabbit isolated vas deferens with dithiothreitol and pertussis toxin.
Pharmacological discrimination between muscarinic receptor signal transduction cascades with bethanechol chloride.
Pharmacological effects mediated by UDP-glucose that are independent of P2Y14 receptor expression.
Pharmacological modulation of the hyperpolarization-activated current (I f) in human atrial myocytes: focus on G protein-coupled receptors.
Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies.
Pharmacological profiles of the novel analgesic M58996 in rat models of persistent and neuropathic pain.
Pharmacological properties of two cloned somatostatin receptors.
Pharmacological study of signal transduction during stimulation of prothoracic glands from Manduca sexta.
Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo.
Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro.
Pharmacologically distinct, pertussis toxin-resistant inward currents evoked by metabotropic glutamate receptor (mGluR) agonists in dorsolateral septal nucleus (DLSN) neurons.
Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture.
Pharmacology of Ca2+ channels in smooth muscle.
Pharmacology of pertussis toxin B-oligomer.
Phase I clinical trial of an acellular pertussis vaccine composed of genetically detoxified pertussis toxin combined with FHA and 69 kDa.
Phase II trial of whole-cell pertussis vaccine vs an acellular vaccine containing agglutinogens.
Phase variation in Bordetella pertussis by frameshift mutation in a gene for a novel two-component system.
Phenotypic and functional evidence for the expression of CXCR4 receptor during megakaryocytopoiesis.
Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic alpha -cells.
Phenylalanine-stimulated secretion of cholecystokinin is calcium dependent.
Phenylephrine acts via IP3-dependent intracellular NO release to stimulate L-type Ca2+ current in cat atrial myocytes.
Phorbol 12-myristate 13-acetate and vasopressin potentiate the effect of corticotropin-releasing factor on cyclic AMP production in rat anterior pituitary cells. Mechanisms of action.
Phorbol ester and phospholipase C-induced growth hormone secretion from pituitary somatotroph adenoma cells in culture: effects of somatostatin, bromocriptine, and pertussis toxin.
Phorbol ester dissociates endothelin-stimulated phosphoinositide hydrolysis and arachidonic acid release in vascular smooth muscle cells.
Phorbol ester modulates serotonin-stimulated phosphoinositide breakdown in cultured vascular smooth muscle cells.
Phorbol ester modulation of cyclic AMP accumulation in a primary culture of rat aortic smooth muscle cells.
Phorbol ester regulates stimulatory and inhibitory pathways of the hormone-sensitive adenylate cyclase system in rat reticulocytes.
Phorbol ester-induced augmentation and inhibition of epinephrine-stimulated adenylate cyclase in S49 lymphoma cells.
Phorbol ester-induced changes in cytoplasmic Ca2+ in human neutrophils. Involvement of a pertussis toxin-sensitive G protein.
Phorbol ester-induced inhibition of the beta-adrenergic system in pulmonary endothelium: role of a pertussis toxin-sensitive protein.
Phorbol esters and thyroliberin have distinct actions regarding stimulation of prolactin secretion and activation of adenylate cyclase in rat pituitary tumour cells (GH4C1 cells).
Phosphate-dependent stimulation of MGP and OPN expression in osteoblasts via the ERK1/2 pathway is modulated by calcium.
Phosphatidic acid and lysophosphatidic acid induce haptotactic migration of human monocytes.
Phosphatidic acid and phospholipase D both stimulate phosphoinositide turnover in cultured human keratinocytes.
Phosphatidic acid inhibits ceramide 1-phosphate-stimulated macrophage migration.
Phosphatidic Acid Stimulates Myoblast Proliferation through Interaction with LPA1 and LPA2 Receptors.
Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation.
Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones.
Phosphatidylinositol 3-kinase mediates inhibitory effect of angiotensin II on sodium/glucose cotransporter in renal epithelial cells.
Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.
Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.
Phosphatidylinositol transfer protein alpha regulates growth and apoptosis of NIH3T3 cells: involvement of a cannabinoid 1-like receptor.
Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance.
Phosphodiesterases inhibition unmask a positive inotropic effect mediated by beta2-adrenoceptors in rat ventricular myocardium.
Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils.
Phosphoinositide metabolism in a polyoma-BK-virus-transformed pancreatic islet cell line: evidence for constitutively activated phospholipase C.
Phosphoinositides and GTP binding proteins involved in muscarinic generation of hippocampal rhythmic slow activity.
Phospholipase A and Somatostatin Release are Activated in Response to N-Methyl-D-Aspartate Receptor Stimulation in Hypothalamic Neurons in Primary Culture.
Phospholipase A2 activation in chemotactic peptide-stimulated HL60 granulocytes: synergism between diacylglycerol and Ca2+ in a protein kinase C-independent mechanism.
Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.
Phospholipase C activation and Ca2+ mobilization by cloned human somatostatin receptor subtypes 1-5, in transfected COS-7 cells.
Phospholipase C activation by neurotensin and neuromedin N in Chinese hamster ovary cells expressing the rat neurotensin receptor.
Phospholipase C activation in rat pituitary adenoma (GH) cells.
Phospholipase C activity in NCB-20 cells is inhibited by protein kinase A-mediated phosphorylation of low molecular mass GTP-binding proteins.
Phospholipase C and phospholipase D are activated independently of each other in chemotactic peptide-stimulated human neutrophils.
Phospholipase C inhibitors attenuate arrhythmias induced by kappa-receptor stimulation in the isolated rat heart.
Phospholipase C isoforms in vascular smooth muscle and their regulation by G-proteins.
Phospholipase C, protein kinase C, Ca(2+)/calmodulin-dependent protein kinase II, and tyrosine phosphorylation are involved in carbachol-induced phospholipase D activation in Chinese hamster ovary cells expressing muscarinic acetylcholine receptor of Caenorhabditis elegans.
Phospholipase C-beta 1 is regulated by a pertussis toxin-insensitive G-protein.
Phospholipase C-beta3 mediates the thrombin-induced Ca2+ response in glial cells.
Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells.
Phospholipase D activity in PC12 cells. Effects of overexpression of alpha2A-adrenergic receptors.
Phospholipase D activity in the Tetrahymena pyriformis GL.
Phospholipase D from photoreceptor rod outer segments is a downstream effector of RhoA: evidence of a light-dependent mechanism.
Phospholipase D is activated by G protein and not by calcium ions in vascular smooth muscle.
Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells.
Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta.
Phospholipid metabolism induced by Clostridium perfringens alpha-toxin elicits a hot-cold type of hemolysis in rabbit erythrocytes.
Phospholipid metabolism is required for M1 muscarinic inhibition of N-type calcium current in sympathetic neurons.
Phospholipids regulate growth and function of MDCK cells in hormonally defined serum free medium.
Phosphorylated BvgA is sufficient for transcriptional activation of virulence-regulated genes in Bordetella pertussis.
Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors.
Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.
Phosphorylation, dephosphorylation, and recycling of the C5a receptor in differentiated HL60 cells.
Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I.
Phosphorylation- and voltage-dependent inhibition of neuronal calcium currents by activation of human D2(short) dopamine receptors.
Phosphorylation-dependent regulation of phospholipase A2 by G-proteins and Ca2+ in HL60 granulocytes.
Photolabeling of Glu-129 of the S-1 subunit of pertussis toxin with NAD.
Photolabelling of mutant forms of the S1 subunit of pertussis toxin with NAD+.
Photolysis of Caged Sphingosine-1-phosphate Induces Barrier Enhancement and Intracellular Activation of Lung Endothelial Cell Signaling Pathways.
Photosensitivity of the isolated pigment epithelium and arachidonic acid metabolism: preliminary results.
Photosensory transduction in ciliates. II. Possible role of G-protein and cGMP in Stentor coeruleus.
Photosensory transduction in ciliates. IV. Modulation of the photomovement response of Blepharisma japonicum by cGMP.
Phototransduction cascade and circadian oscillator in chicken pineal gland.
Phylogenetic approach for inferring the origin and functional evolution of bacterial ADP-ribosylation superfamily.
Physical and functional association of cytosolic inositolphospholipid-specific phospholipase C of calf thymocytes with a GTP-binding protein.
Physical and functional association of follitropin receptors with cholera toxin-sensitive guanine nucleotide-binding protein.
Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex.
Physical evidence of the coupling of solubilized 5-HT1A binding sites with G regulatory proteins.
Physico-chemical analysis of Bordetella pertussis antigens.
Physicochemical characterisation of the pertussis vaccine.
Physiological antagonism between ventricular beta 1-adrenoceptors and alpha 1-adrenoceptors but no evidence for beta 2- and beta 3-adrenoceptor function in murine heart.
Physiological effects and therapeutic potential of proinsulin C-peptide.
Physiological evidence for ?3-adrenoceptor in frog (Rana esculenta) heart.
Physiopathological roles of spontaneously released outer membrane vesicles of Bordetella pertussis.
Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins.
PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1).
PI3Kgamma differentially regulates FcepsilonRI-mediated degranulation and migration of mast cells by and toward antigen.
Pien Tze Huang Alleviates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Mice by Regulating Th1 and Th17 Cells.
Pineal muscarinic phosphoinositide response: pertussis toxin resistant signaling with very low receptor number.
Pinoresinol-4,4'-di-O-beta-D-glucoside from Valeriana officinalis root stimulates calcium mobilization and chemotactic migration of mouse embryo fibroblasts.
Pioglitazone is superior to quetiapine, clozapine and tamoxifen at alleviating experimental autoimmune encephalomyelitis in mice.
Pipette GTP is essential for receptor-mediated regulation of Cl- current in dialysed myocytes from guinea-pig ventricle.
Pituitary adenylate cyclase activating polypeptide induces degranulation of rat peritoneal mast cells via high-affinity PACAP receptor-independent activation of G proteins.
Pituitary adenylate cyclase activating polypeptide induces multiple signaling pathways in rat peritoneal mast cells.
Pituitary adenylate cyclase activating polypeptide stimulates rat Leydig cell steroidogenesis through a novel transduction pathway.
Pituitary adenylate cyclase polypeptide (PACAP) stimulates cyclic AMP formation in pituitary fibroblasts and 3T3 tumor fibroblasts: lack of enhancement by protein kinase C activation.
Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylyl cyclase and phospholipase C activity in rat cerebellar neuroblasts.
Pituitary cell line GH3 expresses two somatostatin receptor subtypes that inhibit adenylyl cyclase: functional expression of rat somatostatin receptor subtypes 1 and 2 in human embryonic kidney 293 cells.
Pituitary PRL secretion induced by tetraethylammonium is inhibited by dopamine through D2 receptors.
PK 11195 blockade of benzodiazepine-induced inhibition of forskolin-stimulated adenylate cyclase activity in the striatum.
PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching.
PKC modulation of inhibitory coupling of angiotensin II receptors with adenylate cyclase in lactotroph cells.
PKD in intestinal epithelial cells: rapid activation by phorbol esters, LPA, and angiotensin through PKC.
PLA2 and secondary metabolites of arachidonic acid control filopodial behavior in neuronal growth cones.
Plasma membrane associated phospholipase C from human platelets: synergistic stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by thrombin and guanosine 5'-O-(3-thiotriphosphate).
Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i).
Plasma Norepinephrine in Hypertensive Rats Reflects ?(2)-Adrenoceptor Release Control Only When Re-Uptake is Inhibited.
Plasmacytoid dendritic cells employ multiple cell adhesion molecules sequentially to interact with high endothelial venule cells molecular basis of their trafficking to lymph nodes.
Plasmin induces smooth muscle cell proliferation.
Plasmin is a potent and specific chemoattractant for human peripheral monocytes acting via a cyclic guanosine monophosphate-dependent pathway.
Platelet activating factor activates MAPK and increases in intracellular calcium via independent pathways in B lymphocytes.
Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils.
Platelet adenylate cyclase and phospholipase C are affected differentially by ADP-ribosylation. Effects on thrombin-mediated responses.
Platelet cytosolic 44-kDa protein is a substrate of cholera toxin-induced ADP-ribosylation and is not recognized by antisera against the alpha subunit of the stimulatory guanine nucleotide-binding regulatory protein.
Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.
Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8.
Platelet pertussis toxin-sensitive G proteins in affective disorders.
Platelet-activating factor (PAF) induces a contraction of isolated smooth muscle cells from guinea pig ileum: intracellular pathway involved.
Platelet-activating factor (PAF) stimulates phosphatidylinositol hydrolysis in human peripheral blood mononuclear leukocytes.
Platelet-activating factor activates mitogen-activated protein kinases through the activation of phosphatidylinositol 3-kinase and tyrosine kinase in human eosinophils.
Platelet-activating factor activates two distinct effector pathways in human eosinophils.
Platelet-activating factor both stimulates and "primes" human polymorphonuclear leukocyte actin filament assembly.
Platelet-activating factor exerts mitogenic activity and stimulates expression of interleukin 6 and interleukin 8 in human lung fibroblasts via binding to its functional receptor.
Platelet-activating factor increases pH(i) in bovine neutrophils through the PI3K-ERK1/2 pathway.
Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway.
Platelet-activating factor induces tyrosine phosphorylation in human neutrophils.
Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin.
Platelet-activating factor mediated potentiation of stimulation-evoked catecholamine release and the rise in intracellular free Ca2+ concentration in adrenal chromaffin cells.
Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line.
Platelet-activating factor stimulates multiple signaling pathways in cultured rat mesangial cells.
Platelet-activating factor stimulates phosphoinositide turnover in neurohybrid NCB-20 cells: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins and inhibition by protein kinase C.
Platelet-activating factor stimulates transcription of the heparin-binding epidermal growth factor-like growth factor in monocytes. Correlation with an increased kappa B binding activity.
Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages.
Platelet-activating factor-induced phosphoinositide metabolism in differentiated U-937 cells in culture.
Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells.
Platelet-activating factor: a putative neuromodulator and mediator in the pathophysiology of brain injury.
Platelet-activating factor: diminished acetylcholine release from rat brain slices is mediated by a Gi protein.
Platelet-conditioned medium increases endothelial electrical resistance independently of cAMP/PKA and cGMP/PKG.
Platelet-derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells.
Platelet-derived sphingosine 1-phosphate induces migration of Jurkat T cells.
Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase.
Platelets from spontaneously hypertensive rats exhibit decreased expression of inhibitory guanine nucleotide regulatory protein. Relation with adenylyl cyclase activity.
Pleiotropic effects of lysophosphatidic acid on striatal astrocytes.
Pleurocidin, a novel antimicrobial peptide, induces human mast cell activation through the FPRL1 receptor.
Pneumocystis carinii infection alters GTP-binding proteins in the lung.
Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis.
Polarized 86Rb+ effluxes in primary cultures of rabbit kidney proximal cells: role of calcium and hypotonicity.
Polarized rabbit type 1 angiotensin II receptors manifest differential rates of endocytosis and recycling.
Polyarginine, polylysine, and protamine mimic the effects of high extracellular calcium concentrations on dispersed bovine parathyroid cells.
Polymerase chain reaction for the detection of Bordetella pertussis in clinical nasopharyngeal aspirates.
Polymerase chain reaction identification of Bordetella pertussis infections in vaccinees and family members in a pertussis vaccine efficacy trial in Germany.
Polymerization of actin in RBL-2H3 cells can be triggered through either the IgE receptor or the adenosine receptor but different signaling pathways are used.
Polymorphism in Bordetella pertussis pertactin and pertussis toxin virulence factors in the United States, 1935-1999.
Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in The Netherlands: temporal trends and evidence for vaccine-driven evolution.
Polymorphism in the pertussis toxin promoter region affecting the DNA-based diagnosis of Bordetella infection.
Polymorphism of Bordetella pertussis isolates circulating for the last 10 years in France, where a single effective whole-cell vaccine has been used for more than 30 years.
Polymorphism of IL-10 gene promoter region: association with T cell proliferative responses after acellular pertussis vaccination in adults.
Polymorphisms in the pertussis toxin promoter in Bordetella bronchiseptica veterinary isolates from Argentina.
Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from that used by chemoattractants.
Polymorphonuclear leukocyte dysregulation during the systemic inflammatory response syndrome.
Polymorphonuclear leukocyte opsonic receptor expression after hypoxia/reoxygenation.
Polymorphonuclear leukocytes activation: in vitro modulation by 6-methoxy-2-naphthylacetic acid, the major active metabolite of nabumetone.
Polyphosphoinositide hydrolysis and protein kinase C activation in guinea pig tracheal smooth muscle cells in culture by leukotriene D4 involve a pertussis toxin sensitive G-protein.
Poor immune responses to a birth dose of diphtheria, tetanus, and acellular pertussis vaccine.
Population dynamics and antigenic drift of Bordetella pertussis following whole cell vaccine replacement, Barcelona, Spain, 1986-2015.
Population dynamics of Bordetella pertussis in Finland and Sweden, neighbouring countries with different vaccination histories.
Population-based incidence of pertussis among adolescents and adults, Minnesota, 1995-1996.
Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells.
Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose.
Positive and negative contractile effects of neuropeptide Y on ventricular cardiomyocytes.
Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes.
Positive and negative inotropic effects of muscarinic receptor stimulation in mouse left atria.
Positive chronotropic responses induced by alpha 1-adrenergic stimulation of normal and "ischemic" Purkinje fibers have different receptor-effector coupling mechanisms.
Positive inotropic effect of carbachol and inositol phosphate levels in mammalian atria after pretreatment with pertussis toxin.
Positive inotropism induced by androgens in isolated left atrium of rat: evidence for a cAMP-dependent transcriptional mechanism.
Positive regulation of human T cell activation by Gi2 proteins and interleukin-8.
Positive regulation of pertussis toxin expression.
Positive vs. negative inotropic effects of carbachol in avian atrial muscle: role of Ni-like protein.
Possible coupling of prostaglandin E2 receptor with pertussis toxin-sensitive guanine nucleotide-binding protein in osteoblast-like cells.
Possible direct linkage of insulin-like growth factor-II receptor with guanine nucleotide-binding proteins.
Possible existence of two subsets of platelet-activating factor receptor to mediate polyphosphoinositide breakdown and calcium influx in neuroblastoma x glioma hybrid NG 108-15 cells.
Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferation.
Possible involvement of a GTP-binding protein, the substrate of islet-activating protein, in receptor-mediated signaling responsible for cell proliferation.
Possible involvement of a pertussis toxin-sensitive GTP-binding protein in protein transport into nuclei isolated from rat liver.
Possible involvement of C-C chemokines in functional augmentation of adhesion molecules in asthmatic patients.
Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells.
Possible involvement of different GTP-binding proteins in noradrenaline- and thrombin-stimulated release of arachidonic acid in rabbit platelets.
Possible involvement of G(i3) protein in augmented contraction of bronchial smooth muscle from antigen-induced airway hyperresponsive rats.
Possible involvement of GTP-binding proteins in 1 alpha,25-dihydroxyvitamin D3 induction of tissue transglutaminase in mouse peritoneal macrophages.
Possible involvement of GTP-binding proteins in growth regulation of human epidermoid carcinoma cell line A431.
Possible involvement of M5 muscarinic receptor in the enhancing actions of the novel gastroprokinetic agent Z-338 on nifedipine-sensitive voltage-dependent Ca2+ currents in guinea pig stomach.
Possible involvement of pertussis toxin substrates (Gi, Go) in desipramine-induced refractoriness of adenylate cyclase in cerebral cortices of rats.
Possible involvement of pertussis toxin-sensitive G protein in hepatocyte growth factor-induced signal transduction in cultured rat hepatocytes: pertussis toxin treatment inhibits activation of phospholipid signaling, calcium oscillation, and mitogen-activated protein kinase.
Possible involvement of pertussis toxin-sensitive G proteins and D2 dopamine receptors in the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex.
Possible involvement of pertussis toxin-sensitive GTP-binding protein(s) in c-fos expression during differentiation of 3T3-L1 fibroblasts to adipocytes.
Possible involvement of phosphatidylinositol-specific phospholipase C related to pertussis toxin-sensitive GTP-binding proteins during adipocyte differentiation of 3T3-L1 fibroblasts: negative regulation of protein kinase C.
Possible involvement of protein kinase C and cyclic AMP-dependent protein kinase in the sodium fluoride-mediated inhibition of cyclic nucleotide accumulation in smooth muscle cells.
Possible involvement of protein kinase C and low molecular weight GTP-binding proteins in thrombin-induced histamine secretion in human platelets.
Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA Pathways in Adherence of Eosinophils to Pulmonary Endothelium.
Possible mechanism of CCL2-induced Akt activation in prostate cancer cells.
Possible mechanism of chrysotile asbestos-stimulated superoxide anion production in guinea pig alveolar macrophages.
Possible participation of an islet B-cell calcium-sensing receptor in insulin release.
Possible participation of histamine H3 receptors in the modulation of noradrenaline release from rat spinal cord slices.
Possible role for G-proteins in behavioral sensitization to cocaine.
Possible role of cGMP in excitatory amino acid induced cytotoxicity in cultured cerebral cortical neurons.
Possible role of striatal adenosine in the modulation of acute ethanol-induced motor incoordination in rats.
Possible roles of neuropeptide Y Y3-receptor subtype in rat aortic endothelial cell proliferation under hypoxia, and its specific signal transduction.
Post- and presynaptic GABA(B) receptor activation in neonatal rat rostral ventrolateral medulla neurons in vitro.
Post-receptor defect accounts for phosphorylase hypersensitivity in cultured diabetic cardiomyocytes.
Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells.
Post-stroke dementia. Nootropic drug modulation of neuronal nicotinic acetylcholine receptors.
Postnatal decrease in muscarinic cholinergic influence on Ca2+ currents of rabbit ventricular cells.
Postreceptor signal transduction mechanisms involved in octreotide-induced inhibition of angiogenesis.
Postsynaptic action mechanism of somatostatin on the membrane excitability in spinal substantia gelatinosa neurons of juvenile rats.
Postsynaptic kainate receptor recycling and surface expression are regulated by metabotropic autoreceptor signalling.
Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to nociceptin/orphanin FQ.
Potassium conductance increased by noradrenaline, opioids, somatostatin, and G-proteins: whole-cell recording from guinea pig submucous neurons.
Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cells.
Potent agonist action of 2-thioether derivatives of adenine nucleotides at adenylyl cyclase-linked P2Y-purinoceptors.
Potent and cooperative feedback inhibition of adenylate cyclase activity by calcium in pituitary-derived GH3 cells.
Potent histamine-releasing activity of atrahagin, a novel snake venom metalloproteinase.
Potential mechanisms involved in the negative coupling between serotonin 5-HT1A receptors and carbachol-stimulated phosphoinositide turnover in the rat hippocampus.
Potential role and mechanism of IFN-gamma inducible protein-10 on receptor activator of nuclear factor kappa-B ligand (RANKL) expression in rheumatoid arthritis.
Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes.
Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells.
Potentiation by adenosine of ATP-evoked dopamine release via a pertussis toxin-sensitive mechanism in rat phaeochromocytoma PC12 cells.
Potentiation by cholera toxin of bradykinin-induced inositol phosphate production in the osteoblast-like cell line MC3T3-E1.
Potentiation by higenamine of the aconitine-induced positive chronotropic effect in isolated right atria of mice: the effects of cholera toxin, forskolin and pertussis toxin.
Potentiation by insulin and insulin-like growth factor-1 of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes.
Potentiation of acetylcholine-induced responses in freshly isolated rabbit aortic endothelial cells.
Potentiation of chemotactic peptide-induced superoxide generation by CD38 ligation in human myeloid cell lines.
Potentiation of cyclic adenosine monophosphate production by thrombin in the human erythroleukemia cell line, HEL.
Potentiation of mitogen-activated protein kinase by ethanol in embryonic liver cells.
Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors.
Potentiation of nicotinic currents by bradykinin in the paratracheal ganglia neurons of rats.
Potentiation of NMDA receptor-mediated transmission in turtle cerebellar granule cells by activation of metabotropic glutamate receptors.
Potentiation of Sulfonylurea Action by an EPAC-selective cAMP Analog in INS-1 cells: comparison of Tolbutamide and Gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx.
Potentiation of the glycine-activated Cl- current by ethanol in cultured mouse spinal neurons.
Potentiation of thyrotropin-releasing hormone-stimulated prolactin mRNA levels in GH3 cells by acetylcholine.
Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids is mediated by N-type voltage-dependent calcium channels.
Poxvirus infection rapidly activates tyrosine kinase signal transduction.
Pre- and postsynaptic GABAB receptors in the hippocampus have different pharmacological properties.
Pre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro.
Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus.
Preactivation permits subsequent stimulation of phospholipase C by G(i)-coupled receptors.
Preconditioning against infarction in the rat heart does not involve a pertussis toxin sensitive G protein.
Preconditioning modulates susceptibility to ischemia-induced arrhythmias in the rat heart: the role of alpha-adrenergic stimulation and K(ATP) channels.
Precoupling of alpha-2B adrenergic receptors and G-proteins in transfected PC-12 cell membranes: influence of pertussis toxin and a lysine-directed cross-linker.
Predominance of alpha 2-adrenoceptors in porcine thyroid: biochemical and pharmacological correlations.
Predominant expression of type II vasoactive intestinal peptide receptors by human T lymphoblastoma cells: transduction of both Ca2+ and cyclic AMP signals.
Preferential involvement of Go and Gz proteins in mediating rat natural killer cell lysis of allogeneic and tumor target cells.
Preferential processing of the S1 subunit of pertussis toxin that is bound to eukaryotic cells.
Pregnancy enhances G protein activation and nitric oxide release from uterine arteries.
Pregnancy switches adrenergic signal transduction in rat and human uterine myocytes as probed by BKCa channel activity.
Pregnenolone sulfate acts through a G-protein-coupled sigma1-like receptor to enhance short term facilitation in adult hippocampal neurons.
Prejunctional alpha 2-adrenoceptors in mouse atria function through G-proteins which are sensitive to N-ethylmaleimide, but not pertussis toxin.
Prejunctional beta-adrenoceptors, angiotensin II and neuropeptide Y receptors on sympathetic nerves in mouse atria are linked to N-ethylmaleimide-susceptible G-proteins.
Prejunctional neuropeptide Y receptors in human kidney and atrium.
Preliminary data from a clinical trial (phase 2) of an acellular pertussis vaccine, J-NIH-6.
Preliminary studies on the development of IgA-loaded chitosan-dextran sulphate nanoparticles as a potential nasal delivery system for protein antigens.
Preliminary studies on the use of pertussis toxin for the modulation of intravaginal SIV transmission in rhesus macaques.
Preliminary X-ray crystallographic analysis of holotoxin from Bordetella pertussis.
Prenatal Stress Impairs Spinal Cord Oligodendrocyte Maturation via BDNF Signaling in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.
Preparation and characterization of Pertussis toxin subunits.
Preparation of filamentous hemagglutinin from Bordetella pertussis and assay for serum antibodies to filamentous hemagglutinin and pertussis toxin for clinical and public health laboratories.
Presence of a functional inhibitory GTP-binding regulatory component, Gi, linked to adenylate cyclase in adipocytes of ob/ob mice.
Presence of delta opioid receptors on a subset of hypothalamic gonadotropin releasing hormone (GnRH) neurons.
Presence of phospholipase C in coated vesicles from bovine brain. Dual regulatory effects of GTP-analogs.
Presence of three pertussis toxin substrates and Go alpha immunoreactivity in both plasma and granule membranes of chromaffin cells.
Pressor actions of arginine vasopressin in pithed Sprague-Dawley, Wistar-Kyoto and spontaneously hypertensive rats before and after treatment with nifedipine or pertussis toxin.
Presynaptic Cav2.1 and Cav2.2 differentially influence release dynamics at hippocampal excitatory synapses.
Presynaptic GABA(B) receptor modulation of glutamate exocytosis from rat cerebrocortical nerve terminals: receptor decoupling by protein kinase C.
Presynaptic GABAB autoreceptor modulation of P/Q-type calcium channels and GABA release in rat suprachiasmatic nucleus neurons.
Presynaptic inhibition and the participation of GABA(B) receptors at neuromuscular junctions of the crab Eriphia spinifrons.
Presynaptic inhibition by concanavalin A: are alpha-latrotoxin receptors involved in action potential-dependent transmitter release?
Presynaptic inhibition by neuropeptide Y and baclofen in hippocampus: insensitivity to pertussis toxin treatment.
Presynaptic inhibition of excitatory synaptic transmission mediated by alpha adrenergic receptors in area CA3 of the rat hippocampus in vitro.
Presynaptic inhibition of gamma lobe neurons is required for olfactory learning in Drosophila.
Presynaptic inhibition of spontaneous acetylcholine release mediated by P2Y receptors at the mouse neuromuscular junction.
Presynaptic inhibition of transmitter release from rat sympathetic neurons by bradykinin.
Presynaptic inhibitory effect of baclofen on hippocampal inhibitory synaptic transmission involves a pertussis toxin-sensitive G-protein.
Presynaptic kappa-opioid receptors on noradrenergic nerve terminals couple to G proteins and interact with the alpha 2-adrenoceptors.
Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons.
Presynaptic muscarinic M(2)-receptor-mediated inhibition of N-type Ca(2+) channels in cultured sphenopalatine ganglion: direct evidence for acetylcholine inhibition of cerebral nitrergic neurogenic vasodilation.
Presynaptic opioid receptors on dopaminergic nerves in the rabbit caudate nucleus: coupling to pertussis toxin-sensitive G-proteins and interaction with D2 autoreceptors?
Pretreatment of cerebellar granule cells with concanavalin A potentiates quisqualate-stimulated phosphoinositide hydrolysis.
Pretreatment of mouse striatal neurons in primary culture with 17 beta-estradiol enhances the pertussis toxin-catalyzed ADP-ribosylation of G alpha o,i protein subunits.
Pretreatment with cholera or pertussis toxin differentially modulates morphine- and beta-endorphin-induced antinociception in the mouse formalin test.
Pretreatment with pertussis toxin blocks morphine- but not beta-endorphin-induced antinociception in the mouse.
Pretreatment with pertussis toxin blocks the protective effects of preconditioning: evidence for a G-protein mechanism.
Pretreatment with pertussis toxin differentially modulates morphine- and beta-endorphin-induced antinociception in the mouse.
Pretreatment with pertussis toxin spinally, but not supraspinally, blocks the cold water swimming-induced antinociception in the mouse.
Prevalence and incidence of adult pertussis in an urban population.
Prevalence of antibody to Bordetella pertussis antigens in serum specimens obtained from 1793 adolescents and adults.
Prevalence of Bordetella pertussis and Bordetella parapertussis infections in Tunisian hospitalized infants: results of a 4-year prospective study.
Prevalence of markers of exposure to Bordetella pertussis among Italian young adults.
Prevalence of Pertussis Antibodies in Maternal Blood, Cord Serum, and Infants From Mothers With and Those Without Tdap Booster Vaccination During Pregnancy in Argentina.
Prevalence of pertussis antibodies in maternal delivery, cord, and infant serum.
Prevalence, diagnosis, and disease course of pertussis in adults with acute cough: a prospective, observational study in primary care.
Prevention of alpha 2-adrenergic inhibition on ADH action by pertussis toxin in rabbit CCT.
Prevention of experimental autoimmune uveoretinitis by intrathymic S-antigen injection.
Prevention of pertussis: An unresolved problem.
Prevention of the agonist binding to gamma-aminobutyric acid B receptors by guanine nucleotides and islet-activating protein, pertussis toxin, in bovine cerebral cortex. Possible coupling of the toxin-sensitive GTP-binding proteins to receptors.
Primary immunization of infants with an acellular pertussis vaccine in a double-blind randomized clinical trial.
Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor.
Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses.
Priming by grepafloxacin on respiratory burst of human neutrophils: its possible mechanism.
Priming effects of granulocyte-macrophage colony-stimulating factor are coupled to cholera toxin-sensitive guanine nucleotide binding protein in human T lymphocytes.
Priming of human neutrophils with N-formyl-methionyl-leucyl-phenylalanine by a calcium-independent, pertussis toxin-insensitive pathway.
Prior exposure to Bordetella species as an exclusion criterion in the baboon model of pertussis.
Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98.
Pro-collagen I COOH-terminal trimer induces directional migration and metalloproteinases in breast cancer cells.
Pro-fibrotic processes in human lung fibroblasts are driven by an autocrine/paracrine endothelinergic system.
Pro-inflammatory effector Th cells transmigrate through anti-inflammatory environments into the murine fetus.
Proadrenomedullin N-terminal 20 peptide (PAMP) inhibits proliferation of human neuroblastoma TGW cells.
Proadrenomedullin N-terminal 20 peptide hyperpolarizes the membrane by activating an inwardly rectifying K+ current in differentiated PC12 cells.
Proadrenomedullin NH2-terminal 20 peptide inhibits the voltage-gated Ca2+ channel current through a pertussis toxin-sensitive G protein in rat pheochromocytoma-derived PC 12 cells.
Probable occurrence of toxin-susceptible G proteins in the nematode Caenorhabditis elegans.
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.
Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants.
Probing the genome-scale metabolic landscape of Bordetella pertussis, the causative agent of whooping cough.
Probiotics and the immunological response to infant vaccinations; a double-blind randomized controlled trial.
Problem solved: a modified enzyme-linked immunosorbent assay for detection of human antibodies to pertussis toxin eliminates false-positive results occurring at analysis of heat-treated sera.
Production and purification of Bordetella pertussis toxin.
Production and release of tumor necrosis factor alfa, interleukin-1B and interleukin-6 by human mononuclear leukocytes stimulated with pertussis toxin.
Production and secretion of pertussis toxin subunits in Bacillus subtilis.
Production of a safe, potent and immunogenic partially purified acellular pertussis vaccine using simple indigenous techniques.
Production of beta-defensin-2 by human colonic epithelial cells induced by Salmonella enteritidis flagella filament structural protein.
Production of cell mass and pertussis toxin by Bordetella pertussis.
Production of nontypeable Haemophilus influenzae HtrA by recombinant Bordetella pertussis with the use of filamentous hemagglutinin as a carrier.
Production of stromal cell-derived factor-1 (SDF-1)and expression of CXCR4 in human bone marrow endothelial cells.
Production of tumor necrosis factors alpha and beta by human mononuclear leukocytes stimulated with mitogens, bacteria, and malarial parasites.
Progesterone and the zona pellucida activate different transducing pathways in the sequence of events leading to diacylglycerol generation during mouse sperm acrosomal exocytosis.
Progesterone induces relaxation of human umbilical cord vascular smooth muscle cells through mPR? (PAQR7).
Progesterone inhibition of Xenopus oocyte adenylate cyclase is not mediated via the Bordetella pertussis toxin substrate.
Progesterone inhibits K conductance in plasma membrane of cultured renal epitheloid MDCK cells.
Progesterone primes zona pellucida-induced activation of phospholipase A2 during acrosomal exocytosis in guinea pig spermatozoa.
PROGESTERONE RECEPTOR A (PRA) and PRB -INDEPENDENT EFFECTS OF PROGESTERONE ON GNRH RELEASE.
Progesterone triggers rapid transmembrane calcium influx and/or calcium mobilization from endoplasmic reticulum, via a pertussis-insensitive G-protein in granulosa cells in relation to luteinization process.
Progestin signaling through an olfactory G protein and membrane progestin receptor-alpha in Atlantic croaker sperm: potential role in induction of sperm hypermotility.
Progress towards the development of new vaccines against whooping cough.
Proinflammatory receptor switch from G?s to G?i signaling by ?-arrestin-mediated PDE4 recruitment in mixed RA synovial cells.
Proinsulin C-peptide and its analogues induce intracellular Ca2+ increases in human renal tubular cells.
Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein.
Prokaryotic peptides that block leukocyte adherence to selectins.
Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to ?-arrestin 2.
Prokineticin-1/endocrine gland-derived vascular endothelial growth factor is a survival factor for human multiple myeloma cells.
Prolactin induced production of cytokines in macrophages involves Ca++ and p42/44 MAP kinase signaling pathway.
Prolactin stimulates integrin-mediated adhesion of circulating mononuclear cells to endothelial cells.
Prolactin-releasing peptide activation of the prolactin promoter is differentially mediated by extracellular signal-regulated protein kinase and c-Jun N-terminal protein kinase.
Proliferation of bovine undifferentiated mammary epithelial cells in vitro is modulated by G-proteins.
Proliferative effect of PGD2 on osteoblast-like cells; independent activation of pertussis toxin-sensitive GTP-binding protein from PGE2 or PGF2 alpha.
Proliferative responses and gamma interferon and tumor necrosis factor production by lymphocytes isolated from tracheobroncheal lymph nodes and spleen of mice aerosol infected with Bordetella pertussis.
Proliferative responses to purified and fractionated Bordetella pertussis antigens in mice immunized with whole-cell pertussis vaccine.
Proliferin induces endothelial cell chemotaxis through a G protein-coupled, mitogen-activated protein kinase-dependent pathway.
Proline-rich tyrosine kinase 2 and Rac activation by chemokine and integrin receptors controls NK cell transendothelial migration.
Prolonged activation of extracellular signal-regulated kinase by a protein kinase C-dependent and N17Ras-insensitive mechanism mediates the proliferative response of G(i/o)-coupled somatostatin sst(4) receptors.
Prolonged activation of inhibitory somatostatin receptors increases adenylate cyclase activity in wild-type and Gs alpha-deficient (cyc-) S49 mouse lymphoma cells.
Prolonged elevation of intracellular cyclic AMP levels in U937 cells increases the number of receptors for and the responses to formylmethionyl-leucylphenylalanine, independently of the differentiation process.
Prolonged incubation with neuropeptide Y upregulates beta-adrenoceptors yet does not cause supersensitivity of beta-adrenoceptor signaling.
Prolonged pertussis toxin treatment affects morphine's action on tuberoinfundibular dopaminergic neuron activity and on prolactin secretion.
Promiscuous G-protein coupled receptor inhibition of transient receptor potential melastatin 3 ion channels by G?? subunits.
Promiscuous or heterogeneous muscarinic receptors in rat atria? I. Schild analysis with simple competitive antagonists.
Promiscuous or heterogeneous muscarinic receptors in rat atria? II. Antagonism of responses to carbachol by pirenzepine.
Promoter of the pertussis toxin operon and production of pertussis toxin.
Promotion of lipolysis in rat adipocytes by pertussis toxin: reversal of endogenous inhibition.
Pronounced direct inhibitory action mediated by adenosine A1 receptor and pertussis toxin-sensitive G protein on the ferret ventricular contraction.
Properties of 1-methyladenine receptors in starfish oocyte membranes: involvement of pertussis toxin-sensitive GTP-binding protein in the receptor-mediated signal transduction.
Properties of a novel GTP-binding protein which is associated with soluble phosphoinositides-specific phospholipase C.
Properties of AT1a and AT1b angiotensin receptors expressed in adrenocortical Y-1 cells.
Properties of Ca2+ currents in acutely dissociated neurons of the chick ciliary ganglion: inhibition by somatostatin-14 and somatostatin-28.
Properties of delta opioid receptor in neuroblastoma NS20Y: receptor activation and neuroblastoma proliferation.
Properties of diazoxide and cromakalim-induced activation of potassium channels in cultured rat and RINm5F insulin-secreting cells; effects of GTP.
Properties of membranous phospholipase C from WRK1 cell: sensitivity to guanylnucleotides and bacterial toxins.
Properties of muscarinic-stimulated adenylate cyclase activity in rat olfactory bulb.
Properties of pertussis toxin B oligomer assembled in vitro from recombinant polypeptides produced by Escherichia coli.
Properties of pertussis toxin mutant PT-9K/129G after formaldehyde treatment.
Properties of the B oligomer of pertussis toxin.
Property of receptor for vasoactive intestinal contractor (VIC) expressed in Xenopus oocytes injected with mRNA from rat intestine.
Propionate induces polymorphonuclear leukocyte activation and inhibits formylmethionyl-leucyl-phenylalanine-stimulated activation.
Propionic acid-induced calcium mobilization in human neutrophils.
Prosaposin receptor: evidence for a G-protein-associated receptor.
Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase.
Prosaposin upregulates AR and PSA expression and activity in prostate cancer cells (LNCaP).
Prosaposin: a new player in cell death prevention of U937 monocytic cells.
Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells.
Prosaptide D5 reverses hyperalgesia: inhibition of calcium channels through a pertussis toxin-sensitive G-protein mechanism in the rat.
Prospective evaluation of an Australian pertussis toxin IgG and IgA enzyme immunoassay.
Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: A mechanism requiring PTX-insensitive G proteins, ERK and JNK.
Prostacylin receptor activation inhibits proliferation of aortic smooth muscle cells by regulating cAMP response element-binding protein- and pocket protein-dependent cyclin a gene expression.
Prostaglandin D(2) Induces IL-8 and GM-CSF by Bronchial Epithelial Cells in a CRTH2-Independent Pathway.
Prostaglandin D2 induces the production of human beta-defensin-3 in human keratinocytes.
Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner.
Prostaglandin E receptors in myometrial cells.
Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons.
Prostaglandin E-prostanoid-3 receptor activation of cyclic AMP response element-mediated gene transcription.
Prostaglandin E2 activates phospholipase C and elevates intracellular calcium in cultured myometrial cells: involvement of EP1 and EP3 receptor subtypes.
Prostaglandin E2 and alpha 2 adrenoceptor agonists inhibit the pentose phosphate shunt in pancreatic islets.
Prostaglandin E2 can bimodally inhibit and stimulate the epididymal adipocyte adenylyl cyclase activity.
Prostaglandin E2 contracts vascular smooth muscle and inhibits potassium currents in vascular smooth muscle cells of rat tail artery.
Prostaglandin E2 inhibits sodium transport in rabbit cortical collecting duct by increasing intracellular calcium.
Prostaglandin E2 is an inhibitor of adenylate cyclase in rabbit proximal tubule.
Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors.
Prostaglandin E2 production in rat IMCD cells. I. Stimulation by dopamine.
Prostaglandin E2 receptors in the heart are coupled to inhibition of adenylyl cyclase via a pertussis toxin sensitive G protein.
Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1.
Prostaglandin E2 upregulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes.
Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation.
Prostaglandin E2-induced arachidonic acid release and catecholamine secretion from cultured bovine adrenal chromaffin cells.
Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner.
Prostaglandin F(2alpha) receptor-dependent regulation of prostaglandin transport.
Prostaglandin F2 alpha activates phospholipase D independently from activation of protein kinase C in osteoblast-like cells.
Prostaglandin F2 alpha and alpha-adrenergic agonists regulate parathyroid cell function via the inhibitory guanine nucleotide regulatory protein.
Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
Prostaglandin modulation of Ca2+ channels in rat sympathetic neurones is mediated by guanine nucleotide binding proteins.
Prostaglandin receptors in NIH 3T3 cells: coupling of one receptor to adenylate cyclase and of a second receptor to phospholipase C.
Prostaglandin-concentration-dependent desensitization of adenylate cyclase in human erythroleukaemia (HEL) cells is abolished by pertussis toxin and enhanced by induction by dimethyl sulphoxide.
Prostaglandin-sensitive adenylyl cyclase of cultured preadipocytes and mature adipocytes of the rat: probable role of Gi in determination of stimulatory or inhibitory action.
Prostaglandins and muscarinic agonists induce cyclic AMP attenuation by two distinct mechanisms in the pregnant-rat myometrium. Interaction between cyclic AMP and Ca2+ signals.
Prostaglandins and the urinary concentrating defect in potassium-depleted rabbits.
Prostaglandins induce calcium influx in human spermatozoa.
Prostaglandins induce proliferation of rat hepatocytes through a prostaglandin E2 receptor EP3 subtype.
Prostaglandins inhibit pancreatic beta-cell replication and long-term insulin secretion by pertussis toxin-insensitive mechanisms but do not mediate the actions of interleukin-1 beta.
Prostaglandins inhibit proliferation of the murine P815 mastocytoma by decreasing cytoplasmic free calcium levels [( Ca+2]i).
Prostaglandins inhibit secretion of histamine and pancreastatin from isolated rat stomach ECL cells.
Prostaglandins mediate the defect in AVP-stimulated cAMP generation in immature collecting duct.
Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression.
Prostanoid EP3 and TP receptors-mediated inhibition of noradrenaline release from the isolated rat stomach.
Prostanoid inhibition of canine parietal cells: mediation by the inhibitory guanosine triphosphate-binding protein of adenylate cyclase.
Prostanoid signaling, localization, and expression of IP receptors in rat thick ascending limb cells.
Prosurvival activity for airway neutrophils in severe asthma.
Protean agonism at alpha2A-adrenoceptors.
Protean effects of a natural peptide agonist of the G protein-coupled secretin receptor demonstrated by receptor mutagenesis.
Protease treatment of pertussis toxin identifies the preferential cleavage of the S1 subunit.
Protease-activated receptor (PAR)-independent growth and pro-inflammatory actions of thrombin on human cultured airway smooth muscle.
Protease-activated receptor-1-mediated DNA synthesis in cardiac fibroblast is via epidermal growth factor receptor transactivation: distinct PAR-1 signaling pathways in cardiac fibroblasts and cardiomyocytes.
Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis.
Protection and humoral immune responses against Bordetella pertussis infection in mice immunized with acellular or cellular pertussis immunogens.
Protection of mice inoculated with purified pertussis toxin and filamentous haemagglutinin against intracerebral challenge with live Bordetella pertussis.
Protective activities in mice of monoclonal antibodies against pertussis toxin.
Protective antigens of Bordetella pertussis mouse-protection test against intracerebral and aerosol challenge of B. pertussis.
Protective effect of acellular pertussis vaccines.
Protective effects of catalpol and rhein in murine experimental autoimmune encephalomyelitis via regulation of T helper (Th) 1, Th2, Th17, and regulatory T cell responses.
Protective effects of human gamma-globulin preparations against experimental aerosol infections of mice with Bordetella pertussis.
Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and phosphatidylinositol 3-kinase (PI3 kinase).
Protective effects of pertussis immunoglobulin (P-IGIV) in the aerosol challenge model.
Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019.
Protective effects of remote ischemic preconditioning in isolated rat hearts.
Protective immunity against Bordetella pertussis by a recombinant DNA vaccine and the effect of coinjection with a granulocyte-macrophage colony stimulating factor gene.
Protective immunogenicity of synthetic peptides selected from the amino acid sequence of Bordetella pertussis toxin subunit S1.
Protective immunogenicity of two synthetic peptides selected from the amino acid sequence of Bordetella pertussis toxin subunit S1.
Protective role of immunoglobulin G antibodies to filamentous hemagglutinin and pertactin of Bordetella pertussis in Bordetella parapertussis infection.
Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2.
Protein intake affects levels of G-protein subunits G alpha i2, G alpha i3, and G beta in rat glomerular membranes.
Protein kinase A phosphorylation and G protein regulation of purified renal Na+ channels in planar bilayer membranes.
Protein kinase A phosphorylation and G protein regulation of type II pneumocyte Na+ channels in lipid bilayers.
Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system.
Protein kinase and G-protein regulation of Ca2+ currents in Hermissenda photoreceptors by 5-HT and GABA.
Protein kinase C activates the non-selective cation channel in the rabbit portal vein.
Protein kinase C activation and positive and negative agonist regulation of 3',5'-cyclic adenosine monophosphate levels in cultured rat Sertoli cells.
Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin.
Protein kinase C activation generates superoxide and contributes to impairment of cerebrovasodilation induced by G protein activation after brain injury.
Protein kinase C activation mimics but does not mediate thyrotropin-induced desensitization of adenylyl cyclase in cultured dog thyroid cells.
Protein kinase C activation stimulates the phosphorylation and internalization of the sst2A somatostatin receptor.
Protein kinase C activator phorbol 12, 13-dibutyrate inhibits platelet activating factor-stimulated Ca2+ mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells.
Protein kinase C activators sensitize cyclic AMP accumulation by intact 1321N1 human astrocytoma cells.
Protein kinase C and G(i/o) proteins are involved in adenosine- and ischemic preconditioning-mediated renal protection.
Protein kinase C and Gi-protein mediated modulation of cAMP production in different stages of the rat seminiferous epithelium.
Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. Cross-talk between G protein-coupled receptors and pp60c-src.
Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase.
Protein kinase C differentially modulates PTH- and PGE2-sensitive adenylate cyclase in osteoblast-like cells.
Protein kinase C enhances growth hormone releasing factor (1-40)-stimulated cyclic AMP levels in anterior pituitary. Actions of somatostatin and pertussis toxin.
Protein kinase C inhibitor chelerythrine attenuates the morphine-induced excitatory amino acid release and reduction of the antinociceptive effect of morphine in rats injected intrathecally with pertussis toxin.
Protein kinase C inhibits arginine vasopressin-stimulated cAMP accumulation via a Gi-dependent mechanism.
Protein kinase C inhibits cyclic adenosine monophosphate generation by histamine and truncated glucagon like peptide 1 in the human gastric cancer cell line HGT-1.
Protein kinase C isoforms and A1 adenosine receptors in porcine coronary smooth muscle cells.
Protein kinase C mediates neurotensin inhibition of inwardly rectifying potassium currents in rat substantia nigra dopaminergic neurons.
Protein kinase C modulates parathyroid hormone- but not prostaglandin E2-mediated stimulation of cyclic AMP production via the inhibitory guanine nucleotide binding protein in UMR-106 osteosarcoma cells.
Protein kinase C potentiates isoproterenol-mediated cyclic AMP production without modifying the homologous desensitization process in J774 cells.
Protein kinase C regulates functional coupling of beta1-adrenergic receptors to Gi/o-mediated responses in cardiac myocytes.
Protein kinase C regulation of the adenylyl cyclase system in rat prostatic epithelium.
Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi.
Protein kinase C-dependent coupling of alpha(2A/D)-adrenergic receptors to phospholipase D.
Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1.
Protein kinase C-independent stimulation of activator protein-1 and c-Jun N-terminal kinase activity in human endometrial cancer cells by the LHRH agonist triptorelin.
Protein kinase C-mediated enhancement of glycine response in rat sacral dorsal commissural neurones by serotonin.
Protein kinase C? as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis.
Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts.
Protein phosphatase 1 and 2A inhibitors prolong the switch in the control of glutamate release by group I metabotropic glutamate receptors: characterization of the inhibitory pathway.
Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to Aroclor 1242, a mixture of polychlorinated biphenyls.
Protein tyrosine phosphatase inhibition by angiotensin II in rat pheochromocytoma cells through type 2 receptor, AT2.
Protein tyrosine phosphorylation and calcium signaling in thyroid FRTL-5 cells.
Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.
Protein-chemical analysis of pertussis toxin reveals homology between the subunits S2 and S3, between S1 and the A chains of enterotoxins of Vibrio cholerae and Escherichia coli and identifies S2 as the haptoglobin-binding subunit.
Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway.
Protein-tyrosine phosphorylations induced by concanavalin A and N-formyl-methionyl-leucyl-phenylalanine in human neutrophils.
Proteinase-activated receptor-1 regulation of macrophage elastase (MMP-12) secretion by serine proteinases.
Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts.
Proteolytic activation of protein kinase Calpha by peroxynitrite in stimulating cytosolic phospholipase A2 in pulmonary endothelium: involvement of a pertussis toxin sensitive protein.
Proteolytic cleavage of pertussis toxin S1 subunit is not essential for its activity in mammalian cells.
Proteolytic processing of the mosquitocidal toxin from Bacillus sphaericus SSII-1.
Prothrombin fragments containing kringle domains induce migration and activation of human neutrophils.
Proximal tubular epithelial cells possess a novel 42-kilodalton guanine nucleotide-binding regulatory protein.
Pseudopterosin A inhibits phagocytosis and alters intracellular calcium turnover in a pertussis toxin sensitive site in Tetrahymena thermophila.
PT pretreatment inhibits 48/80-induced activation of Ca(+)-permeable channels in rat peritoneal mast cells.
PTH and DA regulate Na-K ATPase through divergent pathways.
PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast-like cell line.
PTH-dependent adenylyl cyclase activation in SaOS-2 cells: passage dependent effects on G protein interactions.
PTX cruiser: driving autoimmunity via TLR4.
PTX-sensitive and -insensitive synaptic modulation at the frog neuromuscular junction.
PTX-sensitive G proteins and permissive action of prostacyclin in newborn pig cerebral circulation.
PTX-sensitive signals in bone marrow homing of fetal and adult hematopoietic progenitor cells.
Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts.
Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor.
Pulsatile flow-induced angiogenesis: role of G(i) subunits.
Pulsed-field gel electrophoresis analysis of Bordetella pertussis isolates circulating in Europe from 1998 to 2009.
Pulsed-field gel electrophoresis, pertactin, pertussis toxin S1 subunit polymorphisms, and surfaceome analysis of vaccine and clinical Bordetella pertussis strains.
Purification and characterization of a GTP-binding protein serving as pertussis toxin substrate in starfish oocytes.
Purification and characterization of G proteins from human brain: modification of GTPase activity upon phosphorylation.
Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.
Purification and characterization of predominant G-protein from bovine lung membranes. Biochemical and immunochemical comparison with Gi1 and Go purified from brain.
Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.
Purification and characterization of the heat-labile toxin of Bordetella pertussis.
Purification and characterization of transducin from capybara Hydrochoerus hydrochaeris.
Purification and G protein subunit regulation of a phospholipase C-beta from Xenopus laevis oocytes.
Purification and identification of two pertussis-toxin-sensitive GTP-binding proteins of bovine spleen.
Purification and immunochemical characterization of the major pertussis-toxin-sensitive guanine-nucleotide-binding protein of bovine-neutrophil membranes.
Purification and immunogenicity of a recombinant Bordetella pertussis S1S3FHA fusion protein expressed by Streptococcus gordonii.
Purification and immunological characterization of HPLC-purified pertussis toxin subunits.
Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.
Purification and some properties of GTP-binding proteins from pig heart plasma membranes.
Purification design and practice for pertactin, the third component of acellular pertussis vaccine, from Bordetella pertussis.
Purification from bovine liver membranes of a guanine nucleotide-dependent activator of phosphoinositide-specific phospholipase C. Immunologic identification as a novel G-protein alpha subunit.
Purification of a histamine H3 receptor negatively coupled to phosphoinositide turnover in the human gastric cell line HGT1.
Purification of a novel G-protein alpha 0-subtype from mammalian brain.
Purification of GTP-binding proteins from bovine brain membranes. Identification of heterogeneity of the alpha-subunit of Go proteins.
Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go.
Purification of pertussis toxin substrates from bovine heart membranes.
Purification of pertussis toxin.
Purification of the active C5a receptor from human polymorphonuclear leukocytes as a receptor-Gi complex.
Purification of unique alpha subunits of GTP-binding regulatory proteins (G proteins) by affinity chromatography with immobilized beta gamma subunits.
Purified epithelial Na+ channel complex contains the pertussis toxin-sensitive G alpha i-3 protein.
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.
Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins.
Purine metabolites suppress proliferation of human NK cells through a lineage-specific purine receptor.
Purinergic agonist ATP is a comitogen in thyroid FRTL-5 cells.
Purinergic agonists stimulate the secretion of endothelin-1 in rat thyroid FRTL-5 cells.
Purinergic P2Y receptors on astrocytes are directly coupled to phospholipase A2.
Purinergic P2Y1 receptor signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts.
Purinergic P2Y?? receptor modulates stress-induced hematopoietic stem/progenitor cell senescence.
Purinergic receptor-mediated morphological changes in microglia are transient and independent from inflammatory cytokine release.
Purinergic receptors activating rapid intracellular Ca increases in microglia.
Purinergic receptors on insulin-secreting cells.
Purines and pyrimidines are not involved in NANC relaxant responses in the rabbit vaginal wall.
Purinoceptor-stimulated phosphoinositide hydrolysis in Madin-Darby canine kidney (MDCK) cells.
Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by Gbetagamma-mediated activation of Ras and p38 MAPK.
Pyrimidine nucleotide-evoked inhibition of cyclic AMP accumulation in equine epithelial cells.
Pyrimidinoceptor-mediated activation of phospholipase C and phospholipase A2 in RAW 264.7 macrophages.
Quantification of cell-associated and free antigens in Bordetella pertussis suspensions by antigen binding ELISA.
Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium.
Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay.
Quantification of pertussis toxin, filamentous haemagglutinin, 69 kDa outer membrane protein, agglutinogens 2 and 3 and lipopolysaccharide in the Danish whole-cell pertussis vaccine.
Quantification of the alpha and beta subunits of the transducing elements (Gs and Gi) of adenylate cyclase in adipocyte membranes from lean and obese (ob/ob) mice.
Quantitation of actin polymerization in two human fibroblast sub-types responding to mechanical stretching.
Quantitation of pertussis toxin in an enzyme linked immunosorbent assay with improved specificity.
Quantitative determination of bioactive proteins in diphtheria tetanus acellular pertussis (DTaP) vaccine by liquid chromatography tandem mass spectrometry.
Quantitative determination of pertussis toxin-sensitive G proteins using [32P]ADP-ribosylation in human platelet membranes: negative correlation with ages.
Quantitative priming with inactivated pertussis toxoid vaccine in the aerosol challenge model.
Quantity and quality of antibodies after acellular versus whole cell pertussis vaccines in infants born to mothers who received Tdap during pregnancy: a randomised trial.
Quartz crystal microbalance investigation of the interaction of bacterial toxins with ganglioside containing solid supported membranes.
Quercetin sensitizes RBL-2H3 cells to polybasic mast cell secretagogues through increased expression of Gi GTP-binding proteins linked to a phospholipase C signaling pathway.
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.
R-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphtalenylmethanone (WIN-2) ameliorates experimental autoimmune encephalomyelitis and induces encephalitogenic T cell apoptosis: partial involvement of the CB(2) receptor.
rab3-peptide stimulates exocytosis from mast cells via a pertussis toxin-sensitive mechanism.
Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.
Rac-1-mediated O2- secretion requires Ca2+ influx in neutrophil-like HL-60 cells.
RACK1 regulates angiotensin II-induced contractions of SHR preglomerular vascular smooth muscle cells.
Radioimmunochemical quantification of Gi alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure.
Raf-1 kinase activation by angiotensin II in adrenal glomerulosa cells: roles of Gi, phosphatidylinositol 3-kinase, and Ca2+ influx.
Raf-1 kinase mediates adenylyl cyclase sensitization by TNF-alpha in human airway smooth muscle cells.
Rainbow trout somatostatin receptor subtypes SSTR1A, SSTR1B, and SSTR2 differentially activate the extracellular signal-regulated kinase and phosphatidylinositol 3-kinase signaling pathways in transfected cells.
Ranakinin, a naturally occurring tachykinin, stimulates phospholipase C activity in the frog adrenal gland.
Randomized clinical trial of the safety and immunogenicity of the Tdap vaccine in pregnant Mexican women.
Randomized controlled trial of acellular diphtheria, pertussis and tetanus vaccines in southern Ghana.
Rantes activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cells.
RANTES and platelet-activating factor open Ca2+-activated K+ channels in eosinophils.
RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors.
RANTES stimulates inflammatory cascades and receptor modulation in murine astrocytes.
RANTES, a monocyte and T lymphocyte chemotactic cytokine releases histamine from human basophils.
Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling.
Rapid action of oestrogen in luteinising hormone-releasing hormone neurones: the role of GPR30.
Rapid activation of endothelial NO synthase by estrogen: evidence for a steroid receptor fast-action complex (SRFC) in caveolae.
Rapid activation of phosphatidate phosphohydrolase in mesangial cells by lipid A.
Rapid activation of Ras by fluid flow is mediated by Galpha(q) and Gbetagamma subunits of heterotrimeric G proteins in human endothelial cells.
Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice.
Rapid and non-genomic reduction of intracellular [Ca(2+)] induced by aldosterone in human bronchial epithelium.
Rapid Ca2+ influx and diacylglycerol synthesis in growth hormone-mediated islet beta -cell mitogenesis.
Rapid degradation of NAD by retinoic acid-differentiated HL-60 granulocyte membranes prevents ADP ribosylation.
Rapid depletion of peripheral antigen-specific T cells in TCR-transgenic mice after oral administration of myelin basic protein.
Rapid desensitization of the metabotropic glutamate receptor that facilitates glutamate release in rat cerebrocortical nerve terminals.
Rapid detection of the recently emerged Bordetella pertussis strains with the ptxP3 pertussis toxin promoter allele by real-time PCR.
Rapid effects of androgens in macrophages.
Rapid effects of pesticides on human granulosa-lutein cells.
Rapid elevation of calcium concentration in cultured dorsal spinal cord astrocytes by corticosterone.
Rapid estrogenic regulation of extracellular signal- regulated kinase 1/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A.
Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing.
Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules.
Rapid high mass resolution mass spectrometry using matrix-assisted ionization.
Rapid induction of arachidonic acid release by monocyte chemotactic protein-1 and related chemokines. Role of Ca2+ influx, synergism with platelet-activating factor and significance for chemotaxis.
Rapid induction of Thy-1 antigenic markers on keratinocytes and epidermal immune cells in the skin of mice following topical treatment with common preservatives used in topical medications and in foods.
Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons.
Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor.
Rapid membrane responses to dihydrotestosterone are sex dependent in growth plate chondrocytes.
Rapid nongenomic E2 effects on p42/p44 MAPK, activator protein-1, and cAMP response element binding protein in rat white adipocytes.
Rapid purification of Bordetella pertussis toxin by alternating affinity and hydrophobic chromatography.
Rapid purification of pertussis toxin (PT) and filamentous hemagglutinin (FHA) by cation-exchange chromatography.
Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors. Correlation with increased enzymatic activity.
Rapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases.
Rapid signaling responses in Sertoli cell membranes induced by follicle stimulating hormone and testosterone: Calcium inflow and electrophysiological changes.
Rapid typing of Bordetella pertussis pertussis toxin gene variants by LightCycler real-time PCR and fluorescence resonance energy transfer hybridization probe melting curve analysis.
Ras activation in response to lysophosphatidic acid requires a permissive input from the epidermal growth factor receptor.
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
Ras-independent activation of Ral by a Ca(2+)-dependent pathway.
Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors.
Ras/Rac-Dependent activation of p38 mitogen-activated protein kinases in smooth muscle cells stimulated by cyclic strain stress
Ras/Raf1-dependent signal in sphingosine-1-phosphate-induced tube formation in human coronary artery endothelial cells.
Rat adipose tissue adenosine sensitivity and adenosine content after subcutaneous administration of N6-(phenylisopropyl)adenosine.
Rat brain cannabinoid receptor modulates N-type Ca2+ channels in a neuronal expression system.
Rat fat-cells have three types of adenosine receptors (Ra, Ri and P). Differential effects of pertussis toxin.
Rat group I metabotropic glutamate receptors inhibit neuronal Ca2+ channels via multiple signal transduction pathways in HEK 293 cells.
Rat heart cell membranes contain three substrates for cholera toxin-catalyzed ADP-ribosylation and a single substrate for pertussis toxin-catalyzed ADP-ribosylation.
Rat somatostatin receptor type 1 couples to G proteins and inhibition of cyclic AMP accumulation.
Rat somatostatin sst2(a) and sst2(b) receptor isoforms mediate opposite effects on cell proliferation.
Rat striatal adenosinergic modulation of ethanol-induced motor impairment: possible role of striatal cyclic AMP.
Rat white adipocytes activate p85/p110 PI3K and induce PM GLUT4 in response to adrenoceptor agonists or aluminum fluoride.
Ratiometric analysis of fura red by flow cytometry: a technique for monitoring intracellular calcium flux in primary cell subsets.
Rational medium design for Bordetella pertussis: basic metabolism.
Re-expression of alpha skeletal actin and regulation of alpha 1 adrenoceptor signalling in DOCA-salt hypertension in rats.
Reactivating Immunity Primed by Acellular Pertussis Vaccines in the Absence of Circulating Antibodies: Enhanced Bacterial Control by TLR9 Rather Than TLR4 Agonist-Including Formulation.
Reactive oxygen species contribute to the presynaptic action of extracellular ATP at the frog neuromuscular junction.
Reactive sulfhydryl groups of alpha 39, a guanine nucleotide-binding protein from brain. Location and function.
Reactogenicity and immunogenicity at preschool age of a booster dose of two three-component diphtheria-tetanus-acellular pertussis vaccines in children primed in infancy with acellular vaccines.
Reactogenicity and immunogenicity of a booster dose of a combined diphtheria, tetanus, and tricomponent acellular pertussis vaccine at fourteen to twenty-eight months of age.
Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women.
Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells.
Real-time analysis of very late antigen-4 affinity modulation by shear.
Real-time detection of G protein activation using monomolecular G? FRET sensors.
Reasons for instability of bacterial vaccines.
Rebound stimulation of the cAMP-regulated Cl- current by acetylcholine in guinea-pig ventricular myocytes.
Receptor and G protein-mediated responses to thrombin in HEL cells.
Receptor and mechanism that mediate endothelin- and big endothelin-1-induced phosphoinositide hydrolysis in the rat spinal cord.
Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes.
Receptor mechanisms mediating cyanide generation in PC12 cells and rat brain.
Receptor mechanisms of opioid tolerance in SH-SY5Y human neural cells.
Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase.
Receptor subtype involved and mechanism of norepinephrine-induced stimulation of glutamate uptake into primary cultures of rat brain astrocytes.
Receptor up-regulation, internalization, and interconverting receptor states. Critical components of a quantitative description of N-formyl peptide-receptor dynamics in the neutrophil.
Receptor-effector coupling pathway for alpha 1-adrenergic modulation of abnormal automaticity in 'ischemic' canine Purkinje fibers.
Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme.
Receptor-independent activation of atrial muscarinic potassium channels in the absence of nucleotides.
Receptor-independent activation of guanine nucleotide-binding regulatory proteins by terminal complement complexes.
Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro.
Receptor-independent G protein activation may account for the stimulatory effects of first-generation H1-receptor antagonists in HL-60 cells, basophils, and mast cells.
Receptor-linked early events induced by vasoactive intestinal contractor (VIC) on neuroblastoma and vascular smooth-muscle cells.
Receptor-mediated action of hepoxilin A3 releases diacylglycerol and arachidonic acid from human neutrophils.
Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects.
Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells.
Receptor-mediated activation of phospholipase D by sphingosine 1-phosphate in skeletal muscle C2C12 cells. A role for protein kinase C.
Receptor-mediated autocrine growth-stimulatory effect of 5-hydroxytryptamine on cultured human pancreatic carcinoid cells.
Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways.
Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.
Receptor-mediated internalization is critical for the inhibition of the expression of growth hormone by somatostatin in the pituitary cell line AtT-20.
Receptor-mediated modulation of recombinant neuronal class E calcium channels.
Receptor-mediated phagocytosis in human neutrophils is associated with increased formation of inositol phosphates and diacylglycerol. Elevation in cytosolic free calcium and formation of inositol phosphates can be dissociated from accumulation of diacylglycerol.
Receptor-mediated regulation of calcium channels and neurotransmitter release.
Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain.
Receptor-Mediated Vascular Smooth Muscle Migration Induced by LPA Involves p38 Mitogen-Activated Protein Kinase Pathway Activation.
Receptor-operated calcium influx in rat hepatocytes. Identification and characterization using manganese.
Receptor-regulated interaction of activator of G-protein signaling-4 and Galphai.
Receptor-stimulated dissociation of GTP[S] from Gi-proteins in membranes of HL-60 cells.
Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons.
Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1.
Receptors couple to L-type calcium channels via distinct Go proteins in rat neuroendocrine cell lines.
Receptors for bitter, sweet and umami taste couple to inhibitory G protein signaling pathways.
Receptors for pancreastatin in rat liver membranes: molecular identification and characterization by covalent cross-linking.
Reciprocal inhibition of voltage-gated potassium currents (I K(V)) by activation of cannabinoid CB1 and dopamine D1 receptors in ON bipolar cells of goldfish retina.
Reciprocal modulation of function between the D1 and D2 dopamine receptors and the Na+,K+-ATPase.
Reciprocal modulation of thyrotropin actions by P1-purinergic agonists in FRTL-5 thyroid cells. Inhibition of cAMP pathway and stimulation of phospholipase C-Ca2+ pathway.
Reciprocal protective immunity against Bordetella pertussis and Bordetella parapertussis in a murine model of respiratory infection.
Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis.
Recognition of pertussis toxin by antibodies to synthetic peptides.
Recombinant acellular pertussis vaccine--from the laboratory to the clinic: improving the quality of the immune response.
Recombinant alpha i-3 subunit of G protein activates Gk-gated K+ channels.
Recombinant human CXC-chemokine receptor-4 in melanophores are linked to Gi protein: seven transmembrane coreceptors for human immunodeficiency virus entry into cells.
Recombinant human eotaxin induces oxygen radical production, Ca(2+)-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein.
Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization.
Recombinant human G-CSF and GM-CSF prime human neutrophils for superoxide production through different signal transduction mechanisms.
Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways.
Recombinant interleukin-8 induces changes in cytosolic Ca2+ in human neutrophils.
Recombinant Mycobacterium bovis BCG expressing pertussis toxin subunit S1 induces protection against an intracerebral challenge with live Bordetella pertussis in mice.
Recombinant Production of a Novel Fusion Protein: Listeriolysin O Fragment Fused to S1 Subunit of Pertussis Toxin.
Reconstitution of chemokine-induced actin polymerization in undifferentiated human leukemia cells (HL-60) by heterologous expression of interleukin-8 receptors.
Reconstitution of muscarinic cholinergic inhibition of adenylate cyclase activity in homogenates of embryonic chick hearts by membranes of adult chick hearts.
Reconstitution of somatostatin and muscarinic receptor mediated stimulation of K+ channels by isolated GK protein in clonal rat anterior pituitary cell membranes.
Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein.
Reconstitution of the solubilized mu-opioid receptor coupled to a GTP-binding protein.
Recovery of deficient cholinergic calcium signaling by adenosine in cultured rat cortical astrocytes.
Recovery of endothelium-dependent relaxations four weeks after ischemia and progressive reperfusion in canine coronary arteries.
Recruitment and proliferation of T lymphocytes is supported by IFNgamma- and TNFalpha-activated human osteoblasts: Involvement of CD54 (ICAM-1) and CD106 (VCAM-1) adhesion molecules and CXCR3 chemokine receptor.
Recruitment of actin to the cytoskeletons of human monocyte-like cells activated by complement fragment C5a. Is protein kinase C involved?
Recruitment of individually (all-or-none) responding cells, rather than amplitude enhancement, is the single-cell mechanism subserving the dose-responsive activation of intracellular calcium second messenger signaling by the human luteinizing-hormone receptor.
Recruitment of pleckstrin and phosphoinositide 3-kinase gamma into the cell membranes, and their association with G beta gamma after activation of NK cells with chemokines.
Reduced adenylyl cyclase inhibition by carbachol and GTP during acute myocardial ischaemia.
Reduced concentrations of the alpha-subunit of GTP-binding protein Go in schizophrenic brain.
Reduced G(i) and G(o) protein function in the rat nucleus accumbens attenuates sensorimotor gating deficits.
Reduced glutathione is required for pertussis toxin secretion by Bordetella pertussis.
Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene.
Reduced-antigen, combined diphtheria, tetanus and acellular pertussis vaccine, adsorbed (boostrix®): a review of its properties and use as a single-dose booster immunization.
Reduced-antigen, combined diphtheria, tetanus, and acellular pertussis vaccine, adsorbed (boostrix(®)): a guide to its use as a single-dose booster immunization against pertussis.
Reducing agents and light break an S-S bond activating rhodopsin in vivo in Chlamydomonas.
Reduction of in vivo striatal 5-hydroxytryptamine release by 8-OH-DPAT after inactivation of Gi/G(o) proteins in dorsal raphe nucleus.
Reduction of Pertussis Inflammatory Pathology by Therapeutic Treatment With Sphingosine-1-Phosphate Receptor Ligands by a Pertussis Toxin-Insensitive Mechanism.
Reduction of Potassium Conductances Mediated by Metabotropic Glutamate Receptors in Rat CA3 Pyramidal Cells Does Not Require Protein Kinase C or Protein Kinase A.
Reduction of the same calcium current component by A and C kinases: differential pertussis toxin sensitivity.
Regeneration of entorhinal fibers in mouse slice cultures is age dependent and can be stimulated by NT-4, GDNF, and modulators of G-proteins and protein kinase C.
Regional characterization of G-protein subunits in glomeruli, cortices and medullas of the rat kidney.
Regional differences of the inhibition of GABAB ligand binding by the GTP analogue Gpp(NH)p.
Regional effects of pertussis toxin in vivo and in vitro on GABAB receptor binding in rat brain.
Regulation and functional characterization of a rat recombinant dopamine D3 receptor.
Regulation by bradykinin of phosphoinositide metabolism in the endothelial cells of the pulmonary artery.
Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells.
Regulation by GTP and its stable thiol derivatives of calcium current components in rat nodose ganglion neurons.
Regulation by GTP of a Ca(2+)-activated K+ channel in the apical membrane of rabbit cortical collecting duct cells.
Regulation of 1,2-diacylglycerol production by angiotensin-II in bovine adrenal glomerulosa cells.
Regulation of 5-hydroxytryptamine release from rat midbrain raphe nuclei by 5-hydroxytryptamine1D receptors: effect of tetrodotoxin, G protein inactivation and long-term antidepressant administration.
Regulation of a G protein-gated inwardly rectifying K+ channel by a Ca(2+)-independent protein kinase C.
Regulation of acetyl-CoA carboxylase by ADP-ribosylation.
Regulation of acetylated low density lipoprotein uptake in macrophages by pertussis toxin-sensitive G proteins.
Regulation of acetylcholine release by muscarinic receptors at the mouse neuromuscular junction depends on the activity of acetylcholinesterase.
Regulation of adenylyl cyclase type V/VI in smooth muscle: interplay of inhibitory G protein and Ca2+ influx.
Regulation of adenylyl cyclase, ERK1/2, and CREB by Gz following acute and chronic activation of the delta-opioid receptor.
Regulation of adipogenesis by ceramide 1-phosphate.
Regulation of adrenocortical function by vasopressin.
Regulation of alkaline phosphatase activity by p38 MAP kinase in response to activation of Gi protein-coupled receptors by epinephrine in osteoblast-like cells.
Regulation of alphaIIb beta3 function in human B lymphocytes.
Regulation of angiotensin II-induced G protein signaling by phosducin-like protein.
Regulation of arachidonic acid release and prostaglandin E2 production in thymic epithelial cells by ATPgammaS and transforming growth factor-alpha.
Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways.
Regulation of ATP-dependent surfactant secretion and activation of second-messenger systems in alveolar type II cells.
Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP.
Regulation of atrial natriuretic peptide-stimulated cGMP production in the inner medulla.
Regulation of Basal and stimulated prolactin release in prolactin-secreting rat pituitary tumors*.
Regulation of bradykinin receptor level by cholera toxin, pertussis toxin and forskolin in cultured human fibroblasts.
Regulation of bradykinin- and ATP-activated Ca(2+)-permeable channels in rat pheochromocytoma (PC12) cells.
Regulation of bradykinin-induced Ins(1,4,5)P3 formation by protein kinase C in human fibroblasts.
Regulation of bradykinin-induced phosphoinositide turnover in cultured cerebellar astrocytes: possible role of protein kinase C.
Regulation of Ca2+-sensitive adenylyl cyclase in gonadotropin-releasing hormone neurons.
Regulation of calcitonin secretion in vitro.
Regulation of calcium currents by chemokines and their receptors.
Regulation of calcium homeostasis in sensory neurons by bradykinin.
Regulation of cAMP metabolism by PGE2 in cortical and medullary thick ascending limb of Henle's loop.
Regulation of carbachol- and histamine-induced inositol phospholipid hydrolysis in a human oligodendroglioma.
Regulation of cardiac ?3-adrenergic receptors in hyperglycemia.
Regulation of chemokine-induced transendothelial migration of T lymphocytes by endothelial activation: differential effects on naive and memory T cells.
Regulation of cholecystokinin secretion by peptones and peptidomimetic antibiotics in STC-1 cells.
Regulation of cyclic adenosine 3',5'- monophosphate signaling and pulsatile neurosecretion by Gi-coupled plasma membrane estrogen receptors in immortalized gonadotrophin-releasing hormone neurons.
Regulation of cyclic adenosine 3',5'-monophosphate signaling and pulsatile neurosecretion by Gi-coupled plasma membrane estrogen receptors in immortalized gonadotropin-releasing hormone neurons.
Regulation of cyclic AMP accumulation in lymphoid cells.
Regulation of cyclic AMP formation in cultures of human foetal astrocytes by beta 2-adrenergic and adenosine receptors.
Regulation of cyclic AMP levels by phorbol esters in bovine adrenal medullary cells.
Regulation of cyclic AMP metabolism in rabbit cortical collecting tubule cells by prostaglandins.
Regulation of cytosolic calcium by angiotensins in vascular smooth muscle.
Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea.
Regulation of cytosolic pH in bovine parathyroid cells: effect of fluoride.
Regulation of delta opioid receptors by delta9-tetrahydrocannabinol in NG108-15 hybrid cells.
Regulation of DTH and IgE responses by IL-4 and IFN-gamma in immunized mice given pertussis toxin.
Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1.
Regulation of endothelin-1- and lysophosphatidic acid-stimulated tyrosine phosphorylation of focal adhesion kinase (pp125fak) in Rat-1 fibroblasts.
Regulation of eNOS expression in brain endothelial cells by perinuclear EP(3) receptors.
Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2).
Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodies.
Regulation of expression of early growth response transcription factors in rat primary cortical neurons by extracellular ATP.
Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors.
Regulation of F-actin and endoplasmic reticulum organization by the trimeric G-protein Gi2 in rat hepatocytes. Implication for the activation of store-operated Ca2+ inflow.
Regulation of fibroblast procollagen production. Transforming growth factor-beta 1 induces prostaglandin E2 but not procollagen synthesis via a pertussis toxin-sensitive G-protein.
Regulation of follicle-stimulating hormone binding to receptors on bovine calf testis membranes by cholera toxin-sensitive guanine nucleotide binding protein.
Regulation of formyl peptide receptor binding to rabbit neutrophil plasma membranes. Use of monovalent cations, guanine nucleotides, and bacterial toxins to discriminate among different states of the receptor.
Regulation of G protein activation and effector modulation by fusion proteins between the human 5-hydroxytryptamine(1A) receptor and the alpha subunit of G(i1): differences in receptor-constitutive activity imparted by single amino acid substitutions in G(i1)alpha.
Regulation of G protein-coupled receptor-adenylyl cyclase responsiveness in human airway smooth muscle by exogenous and autocrine adenosine.
Regulation of G proteins by adenosine receptor agonist in coronary artery.
Regulation of G proteins by chronic opiate and clonidine treatment in the guinea pig myenteric plexus.
Regulation of G(q/11)alpha by the gonadotropin-releasing hormone receptor.
Regulation of gadd153 mRNA expression by hypoxia in pulmonary artery smooth muscle cells.
Regulation of gap-junction protein connexin 43 by beta-adrenergic receptor stimulation in rat cardiomyocytes.
Regulation of GH3 pituitary tumour-cell adenylate cyclase activity by activators of protein kinase C.
Regulation of GH3-cell function via adenosine A1 receptors. Inhibition of prolactin release, cyclic AMP production and inositol phosphate generation.
Regulation of glucose carrier activity by AlCl3 and phospholipase C in fat-cells.
Regulation of glucose transport by insulin, bombesin, and bradykinin in Swiss 3T3 fibroblasts: involvement of protein kinase C-dependent and -independent mechanisms.
Regulation of glutamate release from primary afferents and interneurons in the spinal cord by muscarinic receptor subtypes.
Regulation of GTPase and adenylate cyclase activity by amyloid beta-peptide and its fragments in rat brain tissue.
Regulation of guanine nucleotide binding regulatory proteins in cultured adrenal cells by adrenocorticotropin and angiotensin-II.
Regulation of guanine nucleotide turnover on Gi/Go by agonist-stimulated and spontaneously active muscarinic receptors in cardiac membranes.
Regulation of heat-shock protein (hsp70) gene expression by hGH and IL2 in rat Nb2 lymphoma cells.
Regulation of high-conductance anion channels by G proteins and 5-HT1A receptors in CHO cells.
Regulation of homocysteine-induced MMP-9 by ERK1/2 pathway.
Regulation of HSP70 by PTH: a model of gene regulation not mediated by changes in cAMP levels.
Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions.
Regulation of I(Cl,swell) in neuroblastoma cells by G protein signaling pathways.
Regulation of IL-6 synthesis in human peripheral blood mononuclear cells by C3a and C3a(desArg).
Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes.
Regulation of integrin function by CD47 ligands. Differential effects on alpha vbeta 3 and alpha 4beta1 integrin-mediated adhesion.
Regulation of intestinal proglucagon-derived peptide secretion by intestinal regulatory peptides.
Regulation of intracellular calcium by extracellular nucleotides in pig tracheal submucosal gland cells.
Regulation of intracellular free calcium in human myometrial cells by prostaglandin F2 alpha: comparison with oxytocin.
Regulation of intracellular [Ca2+] and GABA release by presynaptic GABAB receptors in rat cerebrocortical synaptosomes.
Regulation of ion content in primary cultures from reabsorptive ducts of human sweat glands studied by X-ray microanalysis.
Regulation of K+ and Ca++ channels by a family of neuropeptide Y receptors.
Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling.
Regulation of kinesin expression and type IV collagenase secretion in invasive human prostate PC-3 tumor sublines.
Regulation of lens cyclic nucleotide metabolism by Ca2+ plus calmodulin.
Regulation of leptin release by insulin, glucocorticoids, G(i)-coupled receptor agonists, and pertussis toxin in adipocytes and adipose tissue explants from obese humans in primary culture.
Regulation of leukotriene-dependent induction of cyclooxygenase-2 and Bcl-2.
Regulation of ligand-receptor dynamics by guanine nucleotides. Real-time analysis of interconverting states for the neutrophil formyl peptide receptor.
Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors.
Regulation of lipolysis by somatotropin: functional alteration of adrenergic and adenosine signaling in bovine adipose tissue.
Regulation of luminol-dependent chemiluminescence and degranulation by bovine neutrophils stimulated with opsonized zymosan.
Regulation of lysophosphatidic acid receptor-stimulated response by G-protein-coupled receptor kinase-2 and beta-arrestin1 in FRTL-5 rat thyroid cells.
Regulation of lysophosphatidic acid-induced COX-2 expression by ERK1/2 activation in cultured feline esophageal epithelial cells.
Regulation of lysophosphatidic acid-stimulated tyrosine phosphorylation of mitogen-activated protein kinase by protein kinase C- and pertussis toxin-dependent pathways in the endothelial cell line EAhy 926.
Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells.
Regulation of melanoma cell adhesion stabilization to fibronectin.
Regulation of melanoma-cell motility by the lipoxygenase metabolite 12-(S)-HETE.
Regulation of membrane associated protein kinase C activity by guanine nucleotide in rabbit peritoneal neutrophils.
Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2).
Regulation of mitogen-activated protein kinase cascades by low density lipoprotein and lysophosphatidic acid.
Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells.
Regulation of mouse placental lactogen secretion by G proteins before midpregnancy.
Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cells.
Regulation of multiple effectors by the cloned delta-opioid receptor: stimulation of phospholipase C and type II adenylyl cyclase.
Regulation of myogenesis by fibroblast growth factors requires beta-gamma subunits of pertussis toxin-sensitive G proteins.
Regulation of Na(+)-pump activity by dopamine in rat tail arteries.
Regulation of Na+,K(+)-ATPase activity by dopamine in cultured rat aortic smooth muscle cells.
Regulation of Na+-K+-ATPase activity in kidney proximal tubules: involvement of GTP binding proteins.
Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein.
Regulation of neutrophil O2- production by neutrophil-endothelial cell interaction via CD11b: its modulation by tumor necrosis factor-alpha (TNF-alpha) and lipopolysaccharide (LPS).
Regulation of NHE3 activity by G protein subunits in renal brush-border membranes.
Regulation of NPY/NPY Y1 receptor/G protein system in rat brain cortex.
Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids.
Regulation of p42 and p44 MAP kinase isoforms in Rat-1 fibroblasts stably transfected with alpha 2C10 adrenoreceptors.
Regulation of p42/p44 MAPK and p38 MAPK by the adenosine A(1) receptor in DDT(1)MF-2 cells.
Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells.
Regulation of parathyroid hormone messenger RNA levels by protein kinase A and C in bovine parathyroid cells.
Regulation of phosphate transport by second messengers in capillaries of the blood-brain barrier.
Regulation of phosphoinositide and phosphatidylcholine phospholipases by G proteins.
Regulation of phospholipase D (PLD) in growth plate chondrocytes by 24R,25-(OH)2D3 is dependent on cell maturation state (resting zone cells) and is specific to the PLD2 isoform.
Regulation of phospholipase D and primary granule secretion by P2-purinergic- and chemotactic peptide-receptor agonists is induced during granulocytic differentiation of HL-60 cells.
Regulation of phospholipase D in human placental trophoblasts by the P(2) purinergic receptor.
Regulation of phosphorylation of Gi2 alpha protein controls the secretory response to isoproterenol in rat parotid tissues.
Regulation of PI hydrolysis and cAMP formation by muscarinic M3 receptor in guinea pig gallbladder.
Regulation of PI3K/Akt signaling by N-desmethylclozapine through activation of ?-opioid receptor.
Regulation of pinocytosis in murine macrophages by colony-stimulating factors and other agents.
Regulation of plasminogen activator inhibitor activity by plasmin in endothelial cells.
Regulation of porcine adipocyte metabolism by insulin and adenosine.
Regulation of prostatic smooth muscle contractility by intracellular second messengers: implications for the conservative treatment of benign prostatic hyperplasia.
Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreading.
Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras.
Regulation of rat hepatocyte function by P2Y receptors: focus on control of glycogen phosphorylase and cyclic AMP by 2-methylthioadenosine 5'-diphosphate.
Regulation of renal cortical Na-HCO3 cotransporter. II. Role of G proteins.
Regulation of renal epithelial sodium channels.
Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization.
Regulation of spontaneous activity of the delta-opioid receptor: studies of inverse agonism in intact cells.
Regulation of spontaneous Ca(2+) spikes by metabotropic glutamate receptors in primary cultures of rat cortical neurons.
Regulation of spontaneous opening of muscarinic K+ channels in rabbit atrium.
Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation.
Regulation of STAT3 by mu-opioid receptors in human neuroblastoma SH-SY5Y cells.
Regulation of striatal cyclic-3',5'-adenosine monophosphate accumulation and GABA release by glutamate metabotropic and dopamine D1 receptors.
Regulation of superoxide anion generation in bovine alveolar macrophages by bacterial lipopolysaccharide, serum proteins, and modulators of signal transduction.
Regulation of synaptic efficacy in hypocretin/orexin-containing neurons by melanin concentrating hormone in the lateral hypothalamus.
Regulation of the action of the novel cholecystokinin-releasing peptide diazepam binding inhibitor by inhibitory hormones and taurocholate.
Regulation of the affinity state of the N-formylated peptide receptor of neutrophils: role of guanine nucleotide-binding proteins and the cytoskeleton.
Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor.
Regulation of the amiloride-blockable sodium channel from epithelial tissue.
Regulation of the CHAPS-solubilized muscarinic receptors by an inhibitory GTP binding protein (Gi) in the brain of neonatal and adult rats.
Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cells.
Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors.
Regulation of the G protein Galphai2 by growth and development in fetal airway epithelium.
Regulation of the G-protein regulatory-G?i signaling complex by nonreceptor guanine nucleotide exchange factors.
Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by mannose 6-phosphate, insulin like growth factors and epidermal growth factor.
Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet activation and comparisons with the adenylate cyclase inhibitory protein, Gi.
Regulation of the phosphoinositide pathway in cultured Sertoli cells from immature rats: effects of follicle-stimulating hormone and fluoride.
Regulation of the potassium current and cytosolic Ca2+ release induced by 2-methylthio ATP in hippocampal neurons.
Regulation of the PRL promoter by Akt through cAMP response element binding protein.
Regulation of the renal Na-HCO3 cotransporter: IV. Mechanisms of the stimulatory effect of angiotensin II.
Regulation of the serum-activated Ca(2+)-dependent chloride channel in Xenopus oocytes.
Regulation of thrombin-induced endothelial cell activation by bacterial toxins.
Regulation of thyrotropin-releasing hormone receptor binding and phospholipase C activation by a single GTP-binding protein.
Regulation of transforming growth factor beta 1 action by multiple transducing pathways: evidence for both G protein-dependent and -independent signaling.
Regulation of transmembrane signal transduction of insulin-like growth factor II by competence type growth factors or viral ras p21.
Regulation of transmembrane signaling by ganglioside GM1: interaction of anti-GM1 with Neuro2a cells.
Regulation of tumour necrosis factor production by mouse peritoneal macrophages: the role of cellular cyclic AMP.
Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor.
Regulation of vascular angiotensin II receptors by EGF.
Regulation of vascular proteoglycan synthesis by angiotensin II type 1 and type 2 receptors.
Regulation of volume-sensitive osmolyte efflux from human SH-SY5Y neuroblastoma cells following activation of lysophospholipid receptors.
Regulation of Xenopus oocyte meiosis arrest by G protein betagamma subunits.
Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling.
Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and G?i-ERK Signaling.
Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity.
Regulator of G-protein signalling 3 redirects prototypical Gi-coupled receptors from Rac1 to RhoA activation.
Regulators involved in the electrically stimulated response of feline esophageal smooth muscle.
Regulators of G protein signaling (RGS) proteins constitutively activate Gbeta gamma-gated potassium channels.
Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells.
Regulatory factors that determine growth and phenotype of normal human melanocytes.
Regulatory mechanisms underlying the modulation of GIRK1/GIRK4 heteromeric channels by P2Y receptors.
Regulatory role of the GTP-binding protein, G(o), in the mechanism of exocytosis in adrenal chromaffin cells.
Relation of the [3H] gamma-hydroxybutyric acid (GHB) binding site to the gamma-aminobutyric acidB (GABAB) receptor in rat brain.
Relationship between increased cyclic AMP-phosphodiesterase activity and abnormal adenylyl cyclase regulation in leukocytes from patients with atopic dermatitis.
Relationship between membrane depolarization and extracellular calcium influx during neutrophil activation.
Relationship between NaF- and thapsigargin-induced endothelium-dependent hyperpolarization in rat mesenteric artery.
Relationship between pH, sodium, and shape changes in chemotactic-factor-stimulated human neutrophils.
Relationship between phospholipase C activation and prostaglandin E2 and cyclic adenosine monophosphate production in rabbit tubular epithelial cells. Effects of angiotensin, bradykinin, and arginine vasopressin.
Relationship between proliferation and cell cycle-dependent Ca2+ influx induced by a combination of thyrotropin and insulin-like growth factor-I in rat thyroid cells.
Relationship between structure and biological and protective activities of pertussis toxin.
Relationship between the inhibition of adenylate cyclase by pentobarbital and the functional coupling of Ns and the catalytic unit.
Relationship between the self-incompatibility and cAMP level in Lilium longiflorum.
Relationship of GTP-binding proteins, phospholipase C, and PGE2 synthesis in rat glomerular mesangial cells.
Relationship of immunogenicity to protective potency in acellular pertussis vaccines.
Relationship of molecular structure to the mechanism of lysophospholipid-induced smooth muscle cell proliferation.
Relationships between dopamine-induced changes in cytosolic free calcium concentration ([Ca2+]i) and rate of prolactin secretion. Elevated [Ca2+]i does not indicate prolactin release.
Relationships between functional assays and enzyme immunoassays as measurements of responses to acellular and whole-cell pertussis vaccines.
Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on the inhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells.
Relaxation of bovine mesenteric arteries by glyceryl trinitrate and other nitro-compounds: evidence for partly different mechanisms of action.
Relaxation of bovine mesenteric artery induced by glyceryl trinitrate is attenuated by pertussis toxin.
Relaxation of evoked contractile activity of isolated guinea-pig ileum by (+/-)-kavain.
Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma.
Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide.
Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor.
Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.
Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling.
Release of guanosine triphosphate binding protein alpha subunits from mouse myocardial membranes: basic properties and their alterations in acute murine Chagas disease.
Release of interleukin-6 by human thyroid epithelial cells immortalized by simian virus 40 DNA transfection.
Release of pertussis toxin and its interaction with outer-membrane antigens.
Release of serotonin from RBL-2H3 cells by the Escherichia coli peptide toxin STb.
Relief from glucose-induced over-stimulation sensitizes the adenylate cyclase-cAMP system of rat pancreatic islets.
Removal of endotoxin from culture supernatant of Bordetella pertussis with aminated poly(gamma-methyl L-glutamate) spherical beads.
Removal of partial agonism from parathyroid hormone (PTH)-related protein-(7-34)NH2 by substitution of PTH amino acids at positions 10 and 11.
Reorientation of macrophage mediator production in endotoxin tolerance.
Reovirus transport--studies using lymphocytosis promoting factor.
Reoxygenation after severe hypoxia induces cardiomyocyte hypertrophy in vitro: activation of CREB downstream of GSK3beta.
Repeated administration of whole-cell and acellular pertussis vaccines affects haemodynamics and autonomic responsiveness.
Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease.
Report on the international workshop on alternatives to the murine histamine sensitization test (HIST) for acellular pertussis vaccines: State of the science and the path forward.
Reporter cell lines for detection of pertussis toxin in acellular pertussis vaccines as a functional animal-free alternative to the in vivo histamine sensitization test.
Requirement for both choleragen and pertussis toxin to obtain maximal activation of adenylate cyclase in cultured cells.
Requirement for G proteins in insulin-like growth factor-I-induced growth of prostate cells.
Requirement for Rho-mediated myosin light chain phosphorylation in thrombin-stimulated cell rounding and its dissociation from mitogenesis.
Requirement of ADP-ribosylation for the pertussis toxin-induced alteration in electrophoretic mobility of G-proteins.
Requirement of Galphai in thymic homing and early T cell development.
Requirement of Gbetagamma and c-Src in D2 dopamine receptor-mediated nuclear factor-kappaB activation.
Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release.
Requirements for assembly of PtlH with the pertussis toxin transporter apparatus of Bordetella pertussis.
Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils.
Requirements for Langerhans' cell depletion following in vitro exposure of murine skin to ultraviolet-B.
Requirements for T lymphocyte migration in explanted lymph nodes.
Rescheduling Behavioral Subunits of a Fixed Action Pattern by Genetic Manipulation of Peptidergic Signaling.
Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15.
Resistance of the insulinotropic action of alpha-D-glucose and beta-L-glucose pentaacetates to cholera and pertussis toxins.
Resolution of a low molecular weight G protein in neutrophil cytosol required for NADPH oxidase activation and reconstitution by recombinant Krev-1 protein.
Resolvin D1 binds human phagocytes with evidence for proresolving receptors.
Resolving TRPV1- and TNF-?-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1.
Response and decline of serum IgG antibodies to pertussis toxin, filamentous hemagglutinin and pertactin in children with pertussis.
Response of human thalamic neurons to high-frequency stimulation.
Response to lysophosphatidic acid in Xenopus oocytes and its rapid desensitization: the role of Gq and Go G-protein families.
Response to prejunctional adenosine receptors is dependent on stimulus frequency.
Responses of pertussis toxin-treated microvascular endothelial cells to transforming growth factor beta 1. No evidence for pertussis-sensitive G-protein involvement in TGF-beta signal transduction.
Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults: A collaborative study in Finland, the Netherlands, and the United Kingdom.
Responses to Bordetella pertussis mutant strains and to vaccination in the coughing rat model of pertussis.
Responses to primary and a booster dose of acellular, component, and whole-cell pertussis vaccines initiated at 2 months of age.
Restoration of the transient outward potassium current by noradrenaline in chagasic canine epicardium.
Resumption of meiosis induced by meiosis-activating sterol has a different signal transduction pathway than spontaneous resumption of meiosis in denuded mouse oocytes cultured in vitro.
Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells.
Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma.
Reticulocyte cytosol activator protein: effects on the stimulatory and inhibitory regulatory proteins of adenylate cyclase.
Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice.
Retinoic acid-induced gene expression of tissue transglutaminase via protein kinase C-dependent pathway in mouse peritoneal macrophages.
Retraction: Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin.
Retrograde transport of pertussis toxin in the mammalian cell.
Reversal by pertussis toxin and N-ethylmaleimide of the facilitation of baroreceptor reflex response by somatostatin in the rat.
Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin.
Reversal of pertussis toxin-induced thermal allodynia by muscarinic cholinergic agonists in mice.
Reversal of somatostatin inhibition of AVP-induced cAMP by pertussis toxin.
Reversal of the CD4(+)/CD8(+) T-cell ratio in lymph node cells upon in vitro mitogenic stimulation by highly purified, water-soluble S3-S4 dimer of pertussis toxin.
Reversible modulation of opioid receptor binding in intact neural cells by endogenous guanosine triphosphate.
Review of the laboratory approaches to the detection of antibody and cell-mediated immunity to pertussis disease and vaccine.
Review of the neutrophil response to Bordetella pertussis infection.
RGS2 blocks slow muscarinic inhibition of N-type Ca(2+) channels reconstituted in a human cell line.
RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells.
RGS4 inhibits Gq-mediated activation of mitogen-activated protein kinase and phosphoinositide synthesis.
Rhes and AGS1/Dexras1 affect signaling by dopamine D1 receptors through adenylyl cyclase.
Rhizobium nod factor signaling. Evidence for a g protein-mediated transduction mechanism
Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells.
Rho GTPases mediated integrin alpha v beta 3 activation in sphingosine-1-phosphate stimulated chemotaxis of endothelial cells.
Rho-mediated cytoskeletal rearrangement in response to LPA is functionally antagonized by Rac1 and PIP2.
Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets.
RhoA- and RhoD-dependent regulatory switch of Galpha subunit signaling by PAR-1 receptors in cellular invasion.
Rhodopsin expressed in Chinese hamster ovary cells regulates adenylyl cyclase activity.
Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands.
Rhythmical bursting activity and GABAergic mechanisms in the medial septum of normal and pertussis toxin-pretreated rats.
Riboflavin: Inhibitory Effects on Receptors, G-Proteins, and Adenylate Cyclase.
Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.
Ric-8A-mediated stabilization of the trimeric G protein subunit G?i is inhibited by pertussis toxin-catalyzed ADP-ribosylation.
Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes.
Rimonabant, a CB1 Inverse Agonist, Inhibits Hepatocyte Lipogenesis by Activating LKB1 and AMPK Axis Downstream of G{alpha}i/o Inhibition.
Ring-deleted analogs of atrial natriuretic factor inhibit adenylate cyclase/cAMP system. Possible coupling of clearance atrial natriuretic factor receptors to adenylate cyclase/cAMP signal transduction system.
Rise in intracellular calcium via a nongenomic effect of allopregnanolone in fetal rat hypothalamic neurons.
Rod-type transducin alpha-subunit mediates a phototransduction pathway in the chicken pineal gland.
Role for cyclic AMP in the postreceptor control of cytokine-stimulated stromal cell growth factor production.
Role in host cell invasion of Trypanosoma cruzi-induced cytosolic-free Ca2+ transients.
Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants.
Role of a guanine nucleotide-binding protein in alpha 1-adrenergic receptor-mediated Ca2+ mobilization in DDT1 MF-2 cells.
Role of a pertussis toxin sensitive G-protein in mediating the effects of phorbol esters on receptor activated cyclic AMP accumulation in Jurkat cells.
Role of a pertussis toxin substrate in the control of lectin-induced cap formation in human neutrophils.
Role of a pertussis toxin-sensitive protein in the modulation of canine Purkinje fiber automaticity.
Role of a protein regulating guanine nucleotide binding in phosphoinositide breakdown and calcium mobilization by bradykinin in neuroblastoma X glioma hybrid NG108-15 cells: effects of pertussis toxin and cholera toxin on receptor-mediated signal transduction.
Role of adenosine A(1) receptors in modulating extracellular adenosine levels.
Role of adenosine on glucagon-induced cAMP in a human cortical collecting duct cell line.
Role of adhesins and toxins in invasion of human tracheal epithelial cells by Bordetella pertussis.
Role of ADP-ribosyltransferase activity of pertussis toxin in toxin-adhesin redundancy with filamentous hemagglutinin during Bordetella pertussis infection.
Role of alpha2-adrenergic receptors and cyclic adenosine monophosphate-dependent protein kinase in the regulation of norepinephrine release in the central nervous system of spontaneously hypertensive rats.
Role of altered G-protein expression in the regulation of myocardial adenylate cyclase activity and force of contraction in spontaneous hypertensive cardiomyopathy in rats.
Role of amino- and carboxyl-terminal regions of G(alphaZ) in the recognition of Gi-coupled receptors.
Role of an aprotinin-sensitive protease in protein kinase Calpha-mediated activation of cytosolic phospholipase A2 by calcium ionophore (A23187) in pulmonary endothelium.
Role of antibodies against Bordetella pertussis virulence factors in adherence of Bordetella pertussis and Bordetella parapertussis to human bronchial epithelial cells.
Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences.
Role of beta 1- and beta 2-adrenoceptors in hypertrophic and apoptotic effects of noradrenaline and adrenaline in adult rat ventricular cardiomyocytes.
Role of beta1- and beta2-adrenergic receptors in regulation of Cl- and Ca2+ channels in guinea pig ventricular myocytes.
Role of Bordetella pertussis virulence factors in adherence to epithelial cell lines derived from the human respiratory tract.
Role of calcium channels in parathyroid hormone secretion.
Role of calcium-sensitive tyrosine kinase Pyk2/CAKbeta/RAFTK in angiotensin II induced Ras/ERK signaling.
Role of cAMP in the functional interaction of carbachol with different cAMP elevating agents in rabbit atrium.
Role of cAMP in the promotion of colorectal cancer cell growth by prostaglandin E2.
Role of cannabinoid CB1 receptors and Gi/o protein activation in the modulation of synaptosomal Na+,K+-ATPase activity by WIN55,212-2 and triangle up9-THC.
Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila.
Role of carbohydrate recognition domains of pertussis toxin in adherence of Bordetella pertussis to human macrophages.
Role of cdk5 and tau phosphorylation in heterotrimeric G protein-mediated retinal growth cone collapse.
Role of ceramide in Ca2+-sensing receptor-induced apoptosis.
Role of chemokine signaling pathways in pancreatic islet rejection during allo- and xenotransplantation.
Role of cholinergic neurons in the motor effects of glucagon-like peptide-2 in mouse colon.
Role of cysteine 41 of the A subunit of pertussis toxin.
Role of D-alanylation of Streptococcus gordonii lipoteichoic acid in innate and adaptive immunity.
Role of dopamine and indolamine derivatives in the regulation of the sea urchin adenylate cyclase.
Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats.
Role of endothelin-1 in regulating proliferation of cultured human uterine smooth muscle cells.
Role of endothelin-1 in regulating proliferation of cultured rabbit airway smooth muscle cells.
Role of Evolutionary Selection Acting on Vaccine Antigens in the Re-Emergence of Bordetella Pertussis.
Role of G alpha q or G alpha o proteins in alpha 1-adrenoceptor subtype-mediated responses in Fischer 344 rat aorta.
Role of G proteins and KCa channels in the muscarinic and beta-adrenergic regulation of airway smooth muscle.
Role of G proteins in agonist-induced Ca2+ sensitization of tracheal smooth muscle.
Role of G proteins in mouse egg activation: stimulatory effects of acetylcholine on the ZP2 to ZP2f conversion and pronuclear formation in eggs expressing a functional m1 muscarinic receptor.
Role of G proteins in shear stress-mediated nitric oxide production by endothelial cells.
Role of G proteins in the acetylcholine-induced potassium current of canine atrial cells.
Role of G proteins in the vasodilator response to endothelin isopeptides in vivo.
Role of G(i)-proteins in norepinephrine-mediated vasoconstriction in rat tail artery smooth muscle.
Role of G-protein beta gamma subunits in the augmentation of P2Y2 (P2U)receptor-stimulated responses by neuropeptide Y Y1 Gi/o-coupled receptors.
Role of G-proteins and adenylate cyclase in antinociception produced by intrathecal purines.
Role of G-proteins in ciliary process adenylyl cyclase responses of the albino rabbit eye.
Role of G-proteins in the regulation of organic osmolyte efflux from isolated rat renal inner medullary collecting duct cells.
Role of GABAB receptors in intracellular Ca2+ homeostasis and possible interaction between GABAA and GABAB receptors in regulation of transmitter release in cerebellar granule neurons.
Role of gelsolin in actin depolymerization of adherent human neutrophils.
Role of Gi proteins in the antidepressant-like effect of amitriptyline and clomipramine.
Role of Go/i subgroup of G proteins in olfactory signaling of Drosophila melanogaster.
Role of Gq alpha in insulin-stimulated glucose uptake by C6 glioma cells.
Role of GTP-binding proteins in the polyunsaturated fatty acid stimulated proliferation of mouse mammary epithelial cells.
Role of GTP-binding proteins in the regulation of mammalian cardiac chloride conductance.
Role of guanine nucleotide binding protein, cytosolic calcium and cAMP in fluoride-induced suppression of PTH secretion.
Role of guanine nucleotide regulatory protein in polyphosphoinositide degradation and activation of phagocytic leukocytes by chemoattractants.
Role of guanine nucleotide regulatory proteins and inositol phosphates in the hormone induced mobilization of hepatocyte calcium.
Role of guanine nucleotide regulatory proteins in insulin stimulation of glucose transport in rat adipocytes. Influence of bacterial toxins.
Role of guanine nucleotide-binding protein and tyrosine kinase in platelet-activating factor activation of phospholipase C in A431 cells: proposal for dual mechanisms.
Role of guanine nucleotide-binding protein in the regulation by adenosine of cardiac potassium conductance and force of contraction. Evaluation with pertussis toxin.
Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle.
Role of heterotrimeric G protein and calcium in cardiomyocyte hypertrophy induced by IGF-1.
Role of histidine 35 of the S1 subunit of pertussis toxin in the ADP-ribosylation of transducin.
Role of intracellular Ca(2+)-stores in the 5-hydroxytryptamine-induced Ca(2+)-current inhibition in NG108-15 hybrid cells.
Role of intracellular Mg2+ in the activation of muscarinic K+ channel in cardiac atrial cell membrane.
Role of intracellular signalling pathways in hydrogen peroxide-induced injury to rat glomerular mesangial cells.
Role of kinases and G-proteins on arachidonate release induced by zymosan in mouse peritoneal macrophages.
Role of L-type Ca(2+) channels in pertussis toxin induced antagonism of U50,488H analgesia and hypothermia.
Role of lipoprotein-associated lysophospholipids in migratory activity of coronary artery smooth muscle cells.
Role of lysophosphatidic acid and rho in glioma cell motility.
Role of M2 muscarinic receptors in airway smooth muscle contraction.
Role of macrophage inflammatory protein-3alpha and its ligand CCR6 in rheumatoid arthritis.
Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis.
Role of mitogen-activated protein kinase in prostaglandin f(2alpha) action in human granulosa-luteal cells.
Role of mitogen-activated protein kinase pathway in prostaglandin F2alpha-induced rat puerperal uterine contraction.
Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line.
Role of MMP-2 in PKCdelta-mediated inhibition of Na+ dependent Ca2+ uptake in microsomes of pulmonary smooth muscle: involvement of a pertussis toxin sensitive protein.
Role of mPR? (PAQR7) in progesterone-induced Ca2+ decrease in human vascular smooth muscle cells.
Role of neutrophils in response to Bordetella pertussis infection in mice.
Role of Ni in coupling angiotensin receptors to inhibition of adenylate cyclase in hepatocytes.
Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin.
Role of NPR-C natriuretic receptor in nitric oxide system activation induced by atrial natriuretic peptide.
Role of nuclear factor-kappa B in the regulation of intercellular adhesion molecule 1 after infection of human bronchial epithelial cells by Bordetella pertussis.
Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice.
Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells.
Role of PCR in the diagnosis of pertussis infection in infants: 5 years' experience of provision of a same-day real-time PCR service in England and Wales from 2002 to 2007.
Role of pertussis toxin A subunit in neutrophil migration and vascular permeability.
Role of pertussis toxin in causing symptoms of Bordetella parapertussis infection.
Role of pertussis toxin sensitive G proteins in the alpha 1 adrenergic receptor but not in the thyrotropin receptor mediated activation of membrane phospholipases and iodide fluxes in FRTL-5 thyroid cells.
Role of pertussis toxin-sensitive G protein in metabolic vasodilation of coronary microcirculation.
Role of pertussis toxin-sensitive G proteins in stimulus-dependent human eosinophil degranulation.
Role of pertussis toxin-sensitive G-protein, K(+) channels, and voltage-gated Ca (2+) channels in the antinociceptive effect of inosine.
Role of pertussis toxin-sensitive G-proteins in intracellular Ca2+ release and apoptosis induced by inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels in HepG2 human hepatoblastoma cells.
Role of pertussis toxin-sensitive G-proteins in synaptic transmission and plasticity at corticostriatal synapses.
Role of pertussis toxin-sensitive G-proteins in the analgesic and anesthetic actions of alpha 2-adrenergic agonists in the rat.
Role of pertussis toxin-sensitive guanosine triphosphate-binding proteins in the response of erythroblasts to erythropoietin.
Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning.
Role of phospholipase A2 and G-proteins in the IgE-dependent activation of mast cells and macrophages.
Role of PKC-? in NADPH oxidase-PKC?-Gi? axis dependent inhibition of ?-adrenergic response by U46619 in pulmonary artery smooth muscle cells.
Role of PKC?-NADPH oxidase signaling axis in PKC?-mediated Gi?2 phosphorylation for inhibition of adenylate cyclase activity by angiotensin II in pulmonary artery smooth muscle cells.
Role of PKC?-p38 MAPK-Gi? axis in peroxynitrite-mediated inhibition of ?-adrenergic response in pulmonary artery smooth muscle cells.
Role of positive charges of neuropeptide Y fragments in mast cell activation.
Role of potassium channels in stretch-promoted atrial natriuretic factor secretion.
Role of potassium channels in the antinociception induced by agonists of alpha2-adrenoceptors.
Role of presynaptic 5-HT1A and 5-HT3 receptors in modulation of synaptic GABA transmission in dissociated rat basolateral amygdala neurons.
Role of prostaglandin E2 in regulation of low and high water osmotic permeability in frog urinary bladder.
Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI2 analogues in rat tail artery: Evidence for Gi/o modulation via EP3 receptors.
Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity.
Role of protein kinase C in ethanol-induced activation of adenylyl cyclase.
Role of protein kinase C in mediating alpha-1-adrenoceptor-induced negative inotropic response in rat ventricles.
Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells.
Role of protein kinase Calpha in signaling from the histamine H(1) receptor to the nucleus.
Role of receptor binding and gene transcription for both the stimulatory and inhibitory effects of interleukin-1 in pancreatic beta-cells.
Role of renal sympathetic nerves in regulating renovascular responses to angiotensin II in spontaneously hypertensive rats.
Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells.
Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells.
Role of secretory and cytosolic phospholipase A(2) enzymes in lysophosphatidylcholine-stimulated monocyte arachidonic acid release.
Role of sodium-hydrogen exchange in the proliferation of immortalised lymphoblasts from patients with essential hypertension and normotensive subjects.
Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome.
Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products.
Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis.
Role of the A subunit of pertussis toxin in alteration of Chinese hamster ovary cell morphology.
Role of the adrenal medulla in stress-induced hyperinsulinaemia in normal mice and in mice infected with Bordetella pertussis or treated with pertussis toxin.
Role of the cell wall microenvironment in expression of a heterologous SpaP-S1 fusion protein by Streptococcus gordonii.
Role of the D2 dopamine receptor in molecular adaptation to chronic hypoxia in PC12 cells.
Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development.
Role of the GTP-binding protein G(o) in the suppressant effect of ethanol on voltage-activated calcium channels of murine sensory neurons.
Role of the protein kinase C signaling pathway in high-density lipoprotein receptor-mediated efflux of intracellular cholesterol.
Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration.
Role of the third intracellular loop and of the cytoplasmic tail in the mitogenic signaling of the protease-activated receptor 1.
Role of tryptophan 26 in the NAD glycohydrolase reaction of the S-1 subunit of pertussis toxin.
Role of two different guanine nucleotide-binding proteins in the antagonistic modulation of the S-type K+ channel by cAMP and arachidonic acid metabolites in Aplysia sensory neurons.
Role of tyrosine kinase in insulin release in an insulin secreting cell line (INS-1).
Roles of atypical protein kinase C in lysophosphatidic acid-induced type II adenylyl cyclase activation in RAW 264.7 macrophages.
Roles of cyclic GMP and inositol trisphosphate in phototransduction of the molluscan extraocular photoreceptor.
Roles of dopamine 2 receptor isoforms and g proteins in ethanol regulated prolactin synthesis and lactotropic cell proliferation.
Roles of Gi and Gq/11 in mediating desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes.
Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.
Roles of heterotrimeric and monomeric G proteins in sperm-induced activation of mouse eggs.
Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studied with receptor knockout mice.
Roles of progesterone receptor membrane component 1 and membrane progestin receptor alpha in regulation of zebrafish oocyte maturation.
Roles of protein kinase C and G proteins in activation of murine resting B lymphocytes by endotoxin-associated protein.
Roles of the disulfide bond and the carboxy-terminal region of the S1 subunit in the assembly and biosynthesis of pertussis toxin.
RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a G?i2-Protein/PI3Kß/?/Nitric Oxide-Coupled Pathway.
S100 protein CP-10 stimulates myeloid cell chemotaxis without activation.
S100A8 Triggers Oxidation-sensitive Repulsion of Neutrophils.
S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine.
S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac.
S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells.
S1P1 and VEGFR-2 form a signaling complex with extracellularly regulated kinase 1/2 and protein kinase C-alpha regulating ML-1 thyroid carcinoma cell migration.
S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress.
S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate.
Saccharomyces boulardii inhibits secretagogue-mediated adenosine 3',5'-cyclic monophosphate induction in intestinal cells.
Safety and efficacy of DTaP-IPV vaccine use in healthcare workers for prevention of pertussis.
Safety and immunogenicity of a combined pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliovirus and Haemophilus influenzae type b-tetanus conjugate vaccine in infants, compared with a whole cell pertussis pentavalent vaccine.
Safety and immunogenicity of a combined Tetanus, Diphtheria, recombinant acellular Pertussis vaccine (TdaP) in healthy Thai adults.
Safety and immunogenicity of a measles, mumps, rubella and varicella vaccine given with combined Haemophilus influenzae type b conjugate/hepatitis B vaccines and combined diphtheria-tetanus-acellular pertussis vaccines.
Safety and immunogenicity of an acellular pertussis vaccine booster in 15- to 20-month-old children previously immunized with acellular or whole-cell pertussis vaccine as infants.
Safety and immunogenicity of Biken acellular pertussis vaccine in combination with diphtheria and tetanus toxoid as a fifth dose at four to six years of age. Munich Vaccine Study Group.
Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers.
Safety and immunogenicity of hydrogen peroxide-inactivated pertussis toxoid in 18-month-old children.
Safety and immunogenicity of six acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fifth dose in four- to six-year-old children.
Safety and immunogenicity of the epicutaneous reactivation of pertussis toxin immunity in healthy adults: a phase I, randomized, double-blind, placebo-controlled trial.
Safety testing of acellular pertussis vaccines: use of animals and 3Rs alternatives.
Safety, immunogenicity and an open, retrospective study of efficacy of a monocomponent pertussis toxoid vaccine in infants.
Salmonella enterica serotype Typhimurium DT104 ArtA-dependent modification of pertussis toxin-sensitive G proteins in the presence of [32P]NAD.
Salt intake and intestinal dopaminergic activity in adult and old Fischer 344 rats.
Salvinorin A exerts opposite presynaptic controls on neurotransmitter exocytosis from mouse brain nerve terminals.
Sar1 translocation onto the ER-membrane for vesicle budding has different pathways for promotion and suppression of ER-to-Golgi transport mediated through H89-sensitive kinase and ER-resident G protein.
Sarafotoxin-induced calcium mobilization in cultured dog tracheal smooth muscle cells.
Scavenger receptor A mediates H2O2 production and suppression of IL-12 release in murine macrophages.
SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor.
SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors.
Schizophrenia Plasma Autoantibodies Promote 'Biased Agonism' at the 5-Hydroxytryptamine 2A Receptor: Neurotoxicity is Positively Modulated by Metabotropic Glutamate 2/3 Receptor Agonism.
Screening of several H-2 congenic mouse strains identified H-2(q) mice as highly susceptible to MOG-induced EAE with minimal adjuvant requirement.
SDF-1 alpha induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells.
SDF-1 suppresses cytokine-induced adhesion of human haemopoietic progenitor cells to immobilized fibronectin.
SDF-1-induced activation of ERK enhances HIV-1 expression.
SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4.
SDF1alpha/CXCR4 signaling stimulates beta-catenin transcriptional activity in rat neural progenitors.
Second messenger pathways involved in up-regulation of an L-type calcium channel.
Second messenger regulation of lipoprotein uptake by an arterial wall model.
Second messengers associated with the action of AII and dopamine D2 receptors in anterior pituitary. Relationship with prolactin secretion.
Second messengers involved in genetic regulation of the number of calcium channels in bovine adrenal chromaffin cells in culture.
Second messengers involved in the control of renin secretion in cultured human nephroblastoma cells.
Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via PI3K/AKT, ERK, and pertussis toxin-sensitive pathways.
Second-messenger generation in PC12 cells. Interactions between cyclic AMP and Ca2+ signals.
Second-messenger regulation of receptor association with clathrin-coated pits: a novel and selective mechanism in the control of CD4 endocytosis.
Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow.
Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor.
Secretion of heterologous proteins in Bacillus subtilis can be improved by engineering cell components affecting post-translocational protein folding and degradation.
Secretion of Matrix Metalloproteinase-9 from Astrocytes by Inhibition of Tonic P2Y(14)-Receptor-Mediated Signal(s).
Secretion of Pertussis Toxin from Bordetella pertussis.
Secretion-stimulating and secretion-inhibiting hormones stimulate high-affinity pertussis-toxin-sensitive GTPases in membranes of a pituitary cell line.
Secretoneurin and chemoattractant receptor interactions.
Secretoneurin promotes pertussis toxin-sensitive neurite outgrowth in cerebellar granule cells.
Secretoneurin-induced in vitro chemotaxis of human monocytes is inhibited by pertussis toxin and an inhibitor of protein kinase C.
Secretory IgA against pertussis toxin and surface structures of Bordetella pertussis in saliva of children with culture proven pertussis.
Secretory IgA-mediated basophil activation. II. Roles of GTP-binding regulatory proteins and phosphatidylinositol 3-kinase.
Secretory phospholipase A2 activates the cascade of mitogen-activated protein kinases and cytosolic phospholipase A2 in the human astrocytoma cell line 1321N1.
Secretory phospholipase A2 induces phospholipase Cgamma-1 activation and Ca2+ mobilization in the human astrocytoma cell line 1321N1 by a mechanism independent of its catalytic activity.
Segment-dependent activation of muscarinic acetylcholine receptor-mediated [35S]Guanosine-5'-O-(gamma-thiotriphosphate) binding in airway tissue membranes.
Selection and emergence of pertussis toxin promoter ptxP3 allele in the evolution of Bordetella pertussis.
Selective ?1B- and ?1D-adrenoceptor antagonists suppress noradrenaline-induced activation, proliferation and ECM secretion of rat hepatic stellate cells in vitro.
Selective A2-adenosine receptor agonists do not alter action potential duration, twitch shortening, or cAMP accumulation in guinea pig, rat, or rabbit isolated ventricular myocytes.
Selective activation by atrial natriuretic factor of phosphatidylcholine-specific phospholipase activities in purified heart muscle plasma membranes.
Selective activation of a chimeric Gi1/Gs G protein alpha subunit by the human IP prostanoid receptor: analysis using agonist stimulation of high affinity GTPase activity and [35S]guanosine-5'-O-(3-thio)triphosphate binding.
Selective activation of Galphao by D2L dopamine receptors in NS20Y neuroblastoma cells.
Selective activation of Gi1 and Gi2 in mouse sperm by the zona pellucida, the egg's extracellular matrix.
Selective activation of heterologously expressed G protein-gated K+ channels by M2 muscarinic receptors in rat sympathetic neurones.
Selective activation of nuclear phospholipase D-1 by g protein-coupled receptor agonists in vascular smooth muscle cells.
Selective antagonism of the AT1 receptor inhibits the effect of angiotensin II on DNA and protein synthesis of rat proximal tubular cells.
Selective attraction of naive and memory B cells by dendritic cells.
Selective blockade of dopamine D-1 receptor by SCH 23390 affects dopamine agonist binding to 3H-spiperone labeled D-2 receptors in rat striatum.
Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons.
Selective blockage by islet-activating protein, pertussis toxin, of negative signal transduction from receptors to adenylate cyclase.
Selective changes in mu opioid receptor properties induced by chronic morphine exposure.
Selective coupling of alpha 2-adrenergic receptor subtypes to cyclic AMP-dependent reporter gene expression in transiently transfected JEG-3 cells.
Selective coupling of different muscarinic acetylcholine receptors to neuronal calcium currents in DNA-transfected cells.
Selective coupling of mouse brain metabotropic sigma receptor with recombinant Gi1.
Selective coupling of purified alpha-subunits of pertussis toxin-substrate GTP-binding proteins to endogenous receptors in rat brain membranes treated with N-ethylmaleimide.
Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection.
Selective decrease in the affinity of D2 dopamine receptor for agonist induced by islet-activating protein, pertussis toxin, associated with ADP-ribosylation of the specific membrane protein of bovine striatum.
Selective enhancement of antagonist ligand binding at muscarinic M2 receptors by heparin due to receptor uncoupling.
Selective enhancement of beta-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes.
Selective expression and cellular localization of pro-inflammatory chemokine ligand/receptor pairs in the sciatic nerves of a severe murine experimental autoimmune neuritis model of Guillain-Barré syndrome.
Selective G-protein regulation of neuronal calcium channels.
Selective inhibition of adenylyl cyclase by octopamine via a human cloned alpha 2A-adrenoceptor.
Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor.
Selective inhibition of beta(2)-adrenergic receptor-mediated cAMP generation by activation of the P2Y(2) receptor in mouse pineal gland tumor cells.
Selective inhibition of high voltage-activated L-type and Q-type Ca2+ currents by serotonin in rat melanotrophs.
Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor.
Selective loss of pertussis toxin-sensitive G-proteins from the plasma membrane after antibody-induced internalization of T-cell surface molecules.
Selective modulation by guanine nucleotides of the high affinity subset of plasma membrane receptors for leukotriene B4 on human polymorphonuclear leukocytes.
Selective mu and kappa Opioid Agonists Inhibit Voltage-Gated Ca2+ Entry in Isolated Neonatal Rat Carotid Body Type I Cells.
Selective parasympathectomy increases the quantity of inhibitory guanine nucleotide-binding proteins in canine cardiac ventricle.
Selective pharmacological inhibitors reveal the role of Syk tyrosine kinase, phospholipase C, phosphatidylinositol-3'-kinase, and p38 mitogen-activated protein kinase in Fc receptor-mediated signaling of chicken heterophil degranulation.
Selective protection of murine cerebral Gi/o-proteins from inactivation by parenterally injected pertussis toxin.
Selective regulation by pertussis toxin of insulin-induced activation of particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes.
Selective regulation of somatostatin receptor subtype signaling: evidence for constitutive receptor activation.
Selective suppression of antigen-specific Th2 cells by continuous micro-dose oral tolerance.
Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated.
Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels.
Selenazoles (selenium compounds) facilitate survival of cultured rat pheochromocytoma PC12 cells after serum-deprivation and stimulate their neuronal differentiation via activation of Akt and mitogen-activated protein kinase, respectively.
Seminal fluid factor increases the resistance of the tight junctional complex of cultured human cervical epithelium CaSki cells.
Semiquantitative polymerase chain reaction enzyme immunoassay for the diagnosis of pertussis.
Sensitivity of adipocyte lipolysis to stimulatory and inhibitory agonists in hypothyroidism and starvation.
Sensitivity of G-protein involved in endothelin-1-induced Ca2+ influx to pertussis toxin in porcine endothelial cells in situ.
Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP gamma[S] binding to pertussis toxin.
Sensitivity of norepinephrine-evoked vasoconstriction to pertussis toxin in the old rat.
Sensitization of adenylate cyclase by halothane in human myocardium and S49 lymphoma wild-type and cyc- cells: evidence for inactivation of the inhibitory G protein Gi alpha.
Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors.
Sensitization of adenylate cyclase induced by a dopamine D2 receptor mutant: inverse agonism by D2 receptor antagonists.
Sensitization of adrenocortical cell adenylate cyclase activity to ACTH by angiotensin II and activators of protein kinase C.
Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors.
Sensitization of human alpha 1- and alpha 2-adrenergic venous responses by guanadrel sulfate.
Sensitization of neuronal A2A adenosine receptors after persistent D2 dopamine receptor activation.
Sensitization of the adenylyl cyclase system in cloned kappa-opioid receptor-transfected cells following sustained agonist treatment: A chimeric study using G protein alpha(i)2/alpha(q) subunits.
Sensitization of the cardiac Na channel to alpha1-adrenergic stimulation by inhalation anesthetics: evidence for distinct modulatory pathways.
Sensitization of the histamine H1 receptor by increased ligand affinity.
Sensitization to cocaine produced by injection of pertussis toxin into the A10 dopamine region.
Sensitization to psychostimulants and stress after injection of pertussis toxin into the A10 dopamine region.
Sensitized heat shock protein 27 induces retinal ganglion cells apoptosis in rat glaucoma model.
Sepsis causes presynaptic histamine H3 and alpha2-adrenergic dysfunction in canine myocardium.
Sequence analysis of bovine retinal S-antigen. Relationships with alpha-transducin and G-proteins.
Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit.
Sequence and structural links between distant ADP-ribosyltransferase families.
Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors.
Sequence variation and conservation in virulence-related genes of Bordetella pertussis isolates from the UK.
Sequence variation in pertussis S1 subunit toxin and pertussis genes in Bordetella pertussis strains used for the whole-cell pertussis vaccine produced in Poland since 1960: efficiency of the DTwP vaccine-induced immunity against currently circulating B. pertussis isolates.
Sequential activation and environmental regulation of virulence genes in Bordetella pertussis.
Sequential activation of MAP kinase cascade by angiotensin II in opossum kidney cells.
Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids.
Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury.
Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch.
Sero epidemiology of Bordetella pertussis immune responses in a healthy population in northern Greece.
Sero-epidemiology of Bordetella pertussis in England and Wales.
Seroepidemiologic study on pertussis, diphtheria, and tetanus in the Fukuoka area of southern Japan: seroprevalence among persons 0-80 years old and vaccination program.
Seroepidemiology of Bordetella pertussis infections in the Spanish population: a cross-sectional study.
Seroepidemiology of diphtheria and pertussis in Beijing, China: A cross-sectional study.
Seroepidemiology of diphtheria and pertussis in Chongqing, China: serology-based evidence of Bordetella pertussis infection.
Seroepidemiology of pertussis in a cross-sectional study of an adult general population in Denmark.
Seroepidemiology of pertussis in China: A population-based, cross-sectional study.
Seroepidemiology of pertussis in Italy.
Seroepidemiology of pertussis infection in an urban childhood population in Cameroon.
Seroepidemiology of whooping cough in the Czech Republic: estimates of incidence of infection in adults.
Serologic diagnosis of pertussis: evaluation of pertussis toxin and other antigens in enzyme-linked immunosorbent assay.
Serologic evidence of subclinical pertussis in immunized children.
Serologic response and antibody-titer decay in adults with pertussis.
Serological correlates in whooping cough.
Serological diagnosis of pertussis: evaluation of IgA against whole cell and specific Bordetella pertussis antigens as markers of recent infection.
Serological responses to infection with B. pertussis.
Seroprevalence and placental transportation of maternal antibodies specific for Neisseria meningitidis serogroup C, Haemophilus influenzae type B, diphtheria, tetanus, and pertussis.
Seroprevalence of an antibody against diphtheria, tetanus, and pertussis among the elderly in Khon Kaen, Thailand.
Seroprevalence of antibodies against diphtheria, tetanus, and pertussis among healthy Thai adolescents.
Seroprevalence of antibodies for pertussis and diphtheria among people leaving or entering China: a cross-sectional study.
Seroprevalence of antibodies to diphtheria, tetanus and pertussis among healthy adolescents and adults in Iran.
Seroprevalence of antibodies to pertussis and diphtheria among healthy adults in China.
Seroprevalence of Antibodies to Pertussis Toxin among Different Age Groups in Thailand after 37 Years of Universal Whole-Cell Pertussis Vaccination.
Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires.
Seroprevalence of Bordetella pertussis antibodies in Flanders (Belgium).
Seroprevalence of Bordetella pertussis antibodies to pertussis toxin among healthy children.
Seroprevalence of Bordetella pertussis Antibody in Children and Adolescents in China.
Seroprevalence of Bordetella pertussis infection during pregnancy measured by IgG antibodies against pertussis toxin.
Seroprevalence of Bordetella pertussis specific Immunoglobulin G antibody levels among asymptomatic individuals aged 4 to 24 years: a descriptive cross sectional study from Sri Lanka.
Seroprevalence of Bordetella pertussis toxin antibodies in children and adolescents in Tunis, Tunisia.
Seroprevalence of IgG antibodies against Bordetella pertussis in healthy individuals aged 4-24 years in Turkey.
Seroprevalence of IgG antibodies to pertussis toxin in children and adolescents in Estonia.
Seroprevalence of IgG antibodies to pertussis toxin in the Slovene population.
Seroprevalence of Immunoglobulin G antibodies against pertussis toxin among asymptomatic medical students in the west of Iran: a cross sectional study.
Seroprevalence of pertussis among healthcare workers: A cross-sectional study from Tunisia.
Seroprevalence of pertussis antibodies among adolescents in Israel.
Seroprevalence of pertussis antitoxin (anti-PT) in Sweden before and 10 years after the introduction of a universal childhood pertussis vaccination program.
Seroprevalence of pertussis in China: Need to improve vaccination strategies.
Seroprevalence of pertussis in The Netherlands: evidence for increased circulation of Bordetella pertussis.
Seroprevalence study of B. pertussis infection in health care workers in Catalonia, Spain.
Serotonergic signalling between thyroid cells: protein kinase C and 5-HT2 receptors in the secretion and action of serotonin.
Serotonergic, 5-HT2, receptor-mediated phosphoinositide turnover and mobilization of calcium in cultured rat retinal pigment epithelium cells.
Serotonin 5-HT2C receptor stimulates cyclic GMP formation in choroid plexus.
Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia.
Serotonin as a major serum factor inducing the phospholipase C-mediated hydrolysis of phosphoinositides in normal rat kidney cells.
Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate.
Serotonin depresses excitatory synaptic transmission and depolarization-evoked Ca2+ influx in rat basolateral amygdala via 5-HT1A receptors.
Serotonin modulates high-voltage-activated Ca2+ channels in rat ventromedial hypothalamic neurons.
Serotonin potentiates angiotensin II--induced vascular smooth muscle cell proliferation.
Serotonin receptor activation leads to neurite outgrowth and neuronal survival.
Serotonin receptor heterogeneity and the role of potassium channels in neuronal excitability.
Serotonin receptor-mediated activation of adenylate cyclase in the neuroblastoma NCB.20: a novel 5-hydroxytryptamine receptor.
Serotonin stimulates a Ca2+ permeant nonspecific cation channel in hepatic endothelial cells.
Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein.
Serotonin stimulates rapid increase of inositol 1,4,5-trisphosphate in ovine uterine artery: correlation with contractile state.
Serotonin type-1D receptor stimulation of A-type K(+) channel decreases membrane excitability through the protein kinase A- and B-Raf-dependent p38 MAPK pathways in mouse trigeminal ganglion neurons.
Serotonin-2 receptors coupled to phosphoinositide hydrolysis in a clonal cell line.
Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway.
Serotonin-induced hypercontraction through 5-hydroxytryptamine 1B receptors in atherosclerotic rabbit coronary arteries.
Serotonin-operated potassium current in CA1 neurons dissociated from rat hippocampus.
Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway.
Serum amyloid A induces chemotaxis of human mast cells by activating a pertussis toxin-sensitive signal transduction pathway.
Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R.
Serum amyloid A induces WISH cell apoptosis.
Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1.
Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-stimulated cAMP Signaling in Murine Osteoblasts.
Serum antibodies against a 69-kilodalton outer-membrane protein, pertactin, from Bordetella pertussis in nonvaccinated children with and without a history of clinical pertussis.
Serum antibodies to diphtheria-tetanus-pertussis vaccine components in Argentine children.
Serum antibodies to the components of diphtheria-tetanus-pertussis vaccine in Polish children related to vaccination status.
Serum antibody response to B. pertussis Tn5 mutants, purified PT and FHA in two different mouse strains and passive protection in the murine intranasal infection model.
Serum antibody response to filamentous hemagglutinin in patients with clinical pertussis measured by an enzyme-linked immunosorbent assay.
Serum contains a potent factor that decreases beta-adrenergic receptor-stimulated L-type Ca2+ current in cardiac myocytes.
Serum factors involved in human microvascular endothelial cell morphogenesis.
Serum from diabetic BB/W rats enhances calcium currents in primary sensory neurons.
Serum IgG antibody response to pertussis toxin in persons for whom pertussis vaccination failed depends upon the number of antigens in the vaccine.
Serum IgG antibody responses to pertussis toxin and filamentous hemagglutinin in nonvaccinated and vaccinated children and adults with pertussis.
Serum IgG, IgA, and IgM responses to pertussis toxin, filamentous hemagglutinin, and agglutinogens 2 and 3 after infection with Bordetella pertussis and immunization with whole-cell pertussis vaccine.
Serum resistance in bvg-regulated mutants of Bordetella pertussis.
Serum uncouples elevation of cyclic adenosine monophosphate concentration from cyclic adenosine monophosphate dependent morphological changes exhibited by cultured pituicytes.
Serum-borne lipids amplify TLR-activated inflammatory responses.
Serum-induced sensitization of cyclic AMP accumulation in 1321N1 human astrocytoma cells.
Serum-induced sensitization of cyclic AMP accumulation in C62B rat glioma cells.
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.
Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying.
Sex differences in EAE reveal common and distinct cellular and molecular components.
Sf9 cells: A versatile model system to investigate the pharmacological properties of G protein-coupled receptors.
Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils.
Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor.
Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.
Shear-dependent eosinophil transmigration on interleukin 4-stimulated endothelial cells: a role for endothelium-associated eotaxin-3.
Shock wave application enhances pertussis toxin protein-sensitive bone formation of segmental femoral defect in rats.
Short Chain Fatty Acids Enhance Expression and Activity of the Umami Taste Receptor in Enteroendocrine Cells via a G?i/o Pathway.
Short- and long-term heterologous sensitization of adenylate cyclase by D4 dopamine receptors.
Short- and long-term regulation of adenylyl cyclase activity by delta-opioid receptor are mediated by Galphai2 in neuroblastoma N2A cells.
Short-chain fatty acid signaling pathways in bovine mammary epithelial cells.
Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E(2) and cytokines.
Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line.
Short-term inhibitory effect of somatostatin on gastric histamine synthesis.
Short-term inverse-agonist treatment induces reciprocal changes in delta-opioid agonist and inverse-agonist binding capacity.
Short-term regulation of Na+,K(+)-ATPase activity by dopamine.
Sigma ligands stimulate the electrical activity of frog pituitary melanotrope cells through a G-protein-dependent inhibition of potassium conductances.
Signal pathway involved in the development of hypoxic preconditioning in rat hepatocytes.
Signal pathway of mitogen-induced Ca2+-activated K+ currents in young and aged T-cell clones of C57BL/6 mice.
Signal pathway regulation of interleukin-8-induced actin polymerization in neutrophils.
Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells.
Signal transducing properties of the N-formyl peptide receptor expressed in undifferentiated HL60 cells.
Signal transduction alterations in GH(1)2C1 rat pituitary tumour cells following treatment with 5-azacytidine.
Signal transduction and glial cell modulation of cultured brain microvessel endothelial cell tight junctions.
Signal transduction and ligand specificity of the human monocyte chemoattractant protein-1 receptor in transfected embryonic kidney cells.
Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells.
Signal transduction by neutrophil immunoglobulin G Fc receptors. Dissociation of intracytoplasmic calcium concentration rise from inositol 1,4,5-trisphosphate.
Signal transduction by tumor necrosis factor alpha is mediated through a guanine nucleotide-binding protein in osteoblast-like cell line, MC3T3-E1.
Signal transduction during antibody-dependent cellular cytotoxicity mediated by U937 cells.
Signal transduction events in Chinese hamster ovary cells expressing human CD14; effect of endotoxin desensitization.
Signal transduction for chemotaxis and haptotaxis by matrix molecules in tumor cells.
Signal transduction for interleukin-3-dependent leukotriene synthesis in normal human basophils: opposing role of tyrosine kinase and protein kinase.
Signal transduction for melatonin in human lymphocytes: involvement of a pertussis toxin-sensitive G protein.
Signal transduction in activation of human eosinophils: G protein-dependent and -independent pathways.
Signal transduction in cells following binding of chemoattractants to membrane receptors.
Signal transduction in Coprinus congregatus: evidence for the involvement of G proteins in blue light photomorphogenesis.
Signal transduction in hamster fibroblasts overexpressing the human EGF receptor.
Signal transduction in human alveolar macrophages: diminished chemotactic response to FMLP correlates with a diminished density of Gi proteins and FMLP receptors.
Signal transduction in human myometrial cells.
Signal transduction in insulin secretion: comparison between fuel stimuli and receptor agonists.
Signal transduction in monocytes and granulocytes measured by multiparameter flow cytometry.
Signal transduction in N-formyl-methionyl-leucyl-phenylalanine and concanavalin A stimulated human neutrophils: superoxide production without a rise in intracellular free calcium.
Signal transduction involved in MCP-1-mediated monocytic transendothelial migration.
Signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils.
Signal transduction mechanism via adenosine A1 receptor in the cat esophageal smooth muscle cells.
Signal transduction mechanism(s) involved in prostacyclin production elicited by acetylcholine in coronary endothelial cells of rabbit heart.
Signal transduction mechanisms for leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils.
Signal transduction mechanisms of C1q-mediated superoxide production. Evidence for the involvement of temporally distinct staurosporine-insensitive and sensitive pathways.
Signal transduction modulation by lithium: cell culture, cerebral microdialysis and human studies.
Signal transduction of a tissue interaction during embryonic heart development.
Signal transduction of arginine vasopressin-induced arachidonic acid release in H9c2 cardiac myoblasts: role of Ca2+ and the protein kinase C-dependent activation of p42 mitogen-activated protein kinase.
Signal transduction of cannabinoid CB1 receptors in a smooth muscle cell line.
Signal transduction of somatostatin in human B lymphoblasts.
Signal transduction pathway for IL-1. Involvement of a pertussis toxin-sensitive GTP-binding protein in the activation of adenylate cyclase.
Signal transduction pathway of the muscarinic receptors mediating gallbladder contraction.
Signal transduction pathways activated by engaging immunoglobulin Fc receptors on chicken heterophils.
Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor.
Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.
Signal transduction pathways mediating CCK-induced gallbladder muscle contraction.
Signal transduction pathways of muscarinic receptors in circular smooth muscle from the rabbit caecum.
Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling.
Signal-dependent translocation of transducin, RGS9-1-Gbeta5L complex, and arrestin to detergent-resistant membrane rafts in photoreceptors.
Signal-transducing GTP-binding proteins of mammalian heart and lungs.
Signal-transduction pathways causing slow synaptic excitation in guinea pig myenteric AH neurons.
Signaling and growth responses of LLC-PK1/Cl4 cells transfected with the rabbit AT1 ANG II receptor.
Signaling characteristics and functional regulation of delta opioid-kappa opioid receptor (DOP-KOP) heteromers in peripheral sensory neurons.
Signaling cross-talk between cannabinoid and muscarinic systems actives Rho-kinase and increases the contractile responses of the bovine ciliary muscle.
Signaling cross-talk from Gbeta4 subunit to Elk-1 in the rapid action of androgens.
Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts.
Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection.
Signaling events initiated by transforming growth factor-beta 1 that require Gi alpha 1.
Signaling mechanisms of angiotensin II-induced attenuation of GABAergic input to hypothalamic presympathetic neurons.
Signaling mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of tyrosine phosphorylation.
Signaling mechanisms that mediate nitric oxide production induced by acetylcholine exposure and withdrawal in cat atrial myocytes.
Signaling mechanisms underlying muscarinic receptor-mediated increase in contraction rate in cultured heart cells.
Signaling networks from Gbeta1 subunit to transcription factors and actin remodeling via a membrane-located ERbeta-related protein in the rapid action of daidzein in osteoblasts.
Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP.
Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression.
Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2.
Signaling pathway of lysophosphatidic Acid-induced contraction in feline esophageal smooth muscle cells.
Signaling pathways downstream of P2 receptors in human neutrophils.
Signaling pathways for tissue factor expression in lipopolysaccharide-stimulated bovine alveolar macrophages.
Signaling pathways in the biphasic effect of angiotensin II on apical Na/H antiport activity in proximal tubule.
Signaling pathways involved in DNA synthesis and migration in response to lysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cells.
Signaling pathways leading to phosphorylation of Akt and GSK-3{beta} by activation of cloned human and cerebral rat D2 and D3 receptors.
Signaling pathways mediating induction of the early response genes prostaglandin G/H synthase-2 and egr-1 by serotonin via 5-HT2A receptors.
Signaling responses to alkyllysophosphatidic acid: the activation of phospholipases A2 and C and protein tyrosine phosphorylation in human platelets.
Signaling through delta opioid receptors on murine splenic T cells and stably transfected Jurkat cells.
Signaling via histamine receptors in cat duodenal smooth muscle cells.
Signalling by CXC-chemokine receptors 1 and 2 expressed in CHO cells: a comparison of calcium mobilization, inhibition of adenylyl cyclase and stimulation of GTPgammaS binding induced by IL-8 and GROalpha.
Signalling components involved in the coupling of alpha 1-adrenoceptors to phospholipase D in neonatal rat cardiac myocytes.
Signalling events mediating the activation of protein kinase C by interleukin-2 in cytotoxic T cells.
Signalling for increased cytoskeletal actin in neutrophils.
Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins.
Signalling mechanism coupled to 5-hydroxytryptamine4 receptor-mediated facilitation of fast synaptic transmission in the guinea-pig ileum myenteric plexus.
Signalling mechanism for somatostatin receptor 5-mediated suppression of AMPA responses in rat retinal ganglion cells.
Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation.
Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes.
Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2.
Signalling pathways activated by 5-HT(1B)/5-HT(1D) receptors in native smooth muscle and primary cultures of rabbit renal artery smooth muscle cells.
Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons.
Signalling pathways involved in the chemotactic activity of CXCL12 in cultured rat cerebellar neurons and CHP100 neuroepithelioma cells.
Signalling pathways involved in the mitogenic action of lysophosphatidylinositol.
Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2.
Signalling properties of lysophosphatidic acid in primary human skin fibroblasts: role of pertussis toxin-sensitive GTP-binding proteins.
Significant cholinergic role in secretin-stimulated exocrine secretion in isolated rat pancreas.
Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis.
Simple Algorithm for Identification of Bordetella pertussis Pertactin Gene Variants.
Simple, efficient purification of filamentous hemagglutinin and pertussis toxin from Bordetella pertussis by hydrophobic and affinity interaction.
Simple, speedy, sensitive, and specific serodiagnosis of pertussis by using a particle agglutination test.
Simulated Microgravity Disrupts Cytoskeleton Organization and Increases Apoptosis of Rat Neural Crest Stem Cells Via Upregulating CXCR4 Expression and RhoA-ROCK1-p38 MAPK-p53 Signaling.
Simulation of generation-collection experiments with homogeneous kinetics: application to electrochemical investigation of superoxide radical anion generation by osteoclasts on bone.
Simultaneous amplification of Bordetella repeated insertion sequences and toxin promoter region gene by polymerase chain reaction.
Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.
Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis.
Simultaneous determination of Bordetella pertussis toxin and filamentous haemagglutinin concentrations by hydroxyapatite high-performance liquid chromatography.
Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.
Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein.
Simvastatin potenciates PGI(2) release induced by HDL in human VSMC: effect on Cox-2 up-regulation and MAPK signalling pathways activated by HDL.
Single Amino Acid Polymorphisms of Pertussis Toxin Subunit S2 (PtxB) Affect Protein Function.
Single transmembrane domain insulin-like growth factor-II/mannose-6-phosphate receptor regulates central cholinergic function by activating a G-protein-sensitive, protein kinase C-dependent pathway.
Single-cell analysis of macrophage chemotactic protein-1-regulated cytosolic Ca2+ increase in human adherent monocytes.
Single-molecule imaging reveals dimerization/oligomerization of CXCR4 on plasma membrane closely related to its function.
Single-Peptide TR-FRET Detection Platform for Cysteine-Specific Post-Translational Modifications.
Single-step purification of pertussis toxin and its subunits by heat-treated fetuin-sepharose affinity chromatography.
Site of pertussis toxin-induced ADP-ribosylation on Gi is critical for receptor modulation of GDP interaction with Gi.
Site-directed mutations in the third intracellular loop of the serotonin 5-HT(1A) receptor alter G protein coupling from G(i) to G(s) in a ligand-dependent manner.
Site-selective homing of antigen-primed lymphocyte populations can play a crucial role in the efferent limb of cell-mediated immune responses in vivo.
Site-specific alterations in the B oligomer that affect receptor-binding activities and mitogenicity of pertussis toxin.
Site-specific antibodies directed against G protein beta and gamma subunits: effects on alpha and beta gamma subunit interaction.
Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity.
Sixteen-month follow-up of antibodies to pertussis toxin after primary immunization with acellular or whole cell vaccine.
Slight hyperinsulinaemia but no hypoglycaemia in pertussis patients.
Slow oscillations of free intracellular calcium ion concentration in human fibroblasts responding to mechanical stretch.
Slug is an essential target of TGFbeta2 signaling in the developing chicken heart.
Small mutations in Bordetella pertussis are associated with selective sweeps.
Small-conductance Cl- channels in rabbit parietal cells activated by prostaglandin E2 and inhibited by GTP gamma S.
Smooth muscle adenosine A1 receptors couple to disparate effectors by distinct G proteins in pregnant myometrium.
Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1).
Smoothened activates Galphai-mediated signaling in frog melanophores.
SNP-based typing: a useful tool to study Bordetella pertussis populations.
Sodium and potassium regulation of guanine nucleotide-stimulated adenylate cyclase in brain.
Sodium fluoride mimics the effect of prostaglandin E2 on catecholamine release from bovine adrenal chromaffin cells.
Sodium ions attenuate the inhibitory effects of neuropeptide Y on norepinephrine release in rat hypothalamus.
Sodium modulates opioid receptors through a membrane component different from G-proteins. Demonstration by target size analysis.
Sodium regulation of opioid agonist binding is potentiated by pertussis toxin.
Sodium saccharin inhibits adenylyl cyclase activity in non-taste cells.
Sodium, hydrogen antiporter activation by extracellular adenosine triphosphate in biliary epithelial cells.
Sodium-dependent calcium efflux from adrenal chromaffin cells following exocytosis. Possible role of secretory vesicle membranes.
Solid phase enzyme immunoassays of pertussis toxin using peroxidase or biotin labelled antibodies.
Solubilization and partial purification from mouse sperm membranes of the specific binding activity for 3-quinuclidinyl benzilate, a potent inhibitor of the zona pellucida-induced acrosome reaction.
Solubilization and reprecipitation from intestinal brush border membranes of a complex containing guanylate cyclase activatable by the heat-stable enterotoxin.
Solubilization from rat pancreatic plasma membranes of a cholecystokinin (CCK) agonist-receptor complex interacting with guanine nucleotide regulatory proteins coexisting in the same macromolecular system.
Solubilization of the vasopressin receptor from rat liver plasma membranes. Evidence for a receptor X GTP-binding protein complex.
Soluble and insoluble immune complexes activate human neutrophil NADPH oxidase by distinct Fc gamma receptor-specific mechanisms.
Soluble CD30 and lymphocyte activation gene-3 (CD223), as potential serological markers of T helper-type cytokine response induced by acellular pertussis vaccine.
Soluble vascular cell adhesion molecule 1 mediation of monocyte chemotaxis in rheumatoid arthritis.
Somatocrinin stimulates adenylate cyclase-Ns regulatory subunit in a GH3 cell-line: comparison with VIP.
Somatostatin activates an inwardly rectifying K+ channel in neonatal rat atrial cells.
Somatostatin activates glibenclamide-sensitive and ATP-regulated K+ channels in insulinoma cells via a G-protein.
Somatostatin activates Ras and ERK1/2 via a G protein ??-subunit-initiated pathway in thyroid cells.
Somatostatin activation of mitogen-activated protein kinase via somatostatin receptor 1 (SSTR1).
Somatostatin acts by inhibiting the cyclic 3',5'-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency.
Somatostatin acts through G-proteins on dopaminergic adenylate cyclase in the caudate-putamen of the rat.
Somatostatin acts via a pertussis toxin-sensitive mechanism on calcitonin secretion in C-cells.
Somatostatin and alpha 2-adrenergic agonists selectively inhibit vasopressin-induced cyclic AMP accumulation in MDCK cells.
Somatostatin and epinephrine decrease insulin messenger ribonucleic acid in HIT cells through a pertussis toxin-sensitive mechanism.
Somatostatin and muscarinic inhibition of canine enteric endocrine cells: cellular mechanisms.
Somatostatin antagonizes angiotensin II effects on mesangial cell contraction and glomerular filtration.
Somatostatin blocks Ca2+ action potential activity in prolactin-secreting pituitary tumor cells through coordinate actions on K+ and Ca2+ conductances.
Somatostatin coordinately regulates glucagon gene expression and exocytosis in HIT-T15 cells.
Somatostatin enhances nerve growth factor-induced neurite outgrowth in PC12 cells.
Somatostatin enhances neurite outgrowth in PC12 cells.
Somatostatin induced hyperpolarization of septal neurons is not blocked by pertussis toxin.
Somatostatin induces an inward rectification in rat locus coeruleus neurones through a pertussis toxin-sensitive mechanism.
Somatostatin induces hyperpolarization in pancreatic islet alpha cells by activating a G protein-gated K+ channel.
Somatostatin induces release of the alpha subunits of pertussis toxin-sensitive G proteins in native membranes and in intact GH4C1 rat pituitary cells.
Somatostatin inhibition of adenylate cyclase activity in different brain areas.
Somatostatin inhibition of anterior pituitary adenylate cyclase activity: different sensitivity between male and female rats.
Somatostatin inhibition of gastrin gene expression: involvement of pertussis toxin-sensitive and -insensitive pathways.
Somatostatin inhibition of phosphoinositides turnover in isolated rat acinar pancreatic cells: interaction with bombesin.
Somatostatin inhibits AP-1 function via multiple protein phosphatases.
Somatostatin inhibits bombesin-stimulated Gi-protein via its own receptor in rabbit colonic smooth muscle cells.
Somatostatin inhibits cAMP-dependent and cAMP-independent calcium influx in the clonal pituitary tumor cell line AtT-20 through the same receptor population.
Somatostatin inhibits cAMP-mediated cholinergic transmission in the myenteric plexus.
Somatostatin inhibits CCK release by inhibiting secretion and action of CCK-releasing peptide.
Somatostatin inhibits excitatory transmission at rat hippocampal synapses via presynaptic receptors.
Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules.
Somatostatin inhibits follicle-stimulating hormone-induced adenylyl cyclase activity and proliferation in immature porcine Sertoli cell via sst2 receptor.
Somatostatin inhibits insulin secretion by a G-protein-mediated decrease in Ca2+ entry through voltage-dependent Ca2+ channels in the beta cell.
Somatostatin inhibits interleukin 6 release from rat cortical type I astrocytes via the inhibition of adenylyl cyclase.
Somatostatin inhibits PDGF-stimulated Ras activation in human neuroblastoma cells.
Somatostatin inhibits stem cell factor messenger RNA expression by Sertoli cells and stem cell factor-induced DNA synthesis in isolated seminiferous tubules.
Somatostatin inhibits the norepinephrine-activated calcium channels in rMTC 6-23 cells: possible involvement of a pertussis toxin-sensitive G-protein.
Somatostatin inhibits vasopressin-stimulated phosphoinositide hydrolysis and influx of extracellular calcium in clonal hamster beta (HIT) cells.
Somatostatin modulates high-voltage-activated Ca2+ channels in freshly dissociated rat hippocampal neurons.
Somatostatin modulates voltage-dependent Ca2+ channels in GH3 cells via a specific G(o) splice variant.
Somatostatin modulates voltage-gated K(+) and Ca(2+) currents in rod and cone photoreceptors of the salamander retina.
Somatostatin modulation of adenosine receptor coupled G-protein subunits in the caudate nucleus of the rat.
Somatostatin peptides inhibit basolateral potassium channels in human colonic crypts.
Somatostatin peptides produce multiple effects on gating properties of native cone photoreceptor cGMP-gated channels that depend on circadian phase and previous illumination.
Somatostatin potentiates NMDA receptor function via activation of InsP(3) receptors and PKC leading to removal of the Mg(2+) block without depolarization.
Somatostatin potentiates the alpha 1-adrenergic activation of phospholipase C in striatal astrocytes through a mechanism involving arachidonic acid and glutamate.
Somatostatin prevents the desensitizing action of growth hormone-releasing factor on growth hormone release.
Somatostatin receptor subtype 4 modulates L-type calcium channels via G?? and PKC signaling in rat retinal ganglion cells.
Somatostatin receptor subtypes sst1 and sst2 elicit opposite effects on the response to glutamate of mouse hypothalamic neurones: an electrophysiological and single cell RT-PCR study.
Somatostatin receptor subtypes SSTR2 and SSTR5 couple negatively to an L-type Ca2+ current in the pituitary cell line AtT-20.
Somatostatin receptor-mediated arachidonic acid mobilization: evidence for partial agonism of synthetic peptides.
Somatostatin receptors (sst2) are coupled to Go and modulate GTPase activity in the rabbit retina.
Somatostatin receptors are expressed by immature cerebellar granule cells: evidence for a direct inhibitory effect of somatostatin on neuroblast activity.
Somatostatin receptors in Neuro2A neuroblastoma cells: ligand internalization.
Somatostatin receptors in Neuro2A neuroblastoma cells: operational characteristics.
Somatostatin receptors on canine fundic D-cells: evidence for autocrine regulation of gastric somatostatin.
Somatostatin receptors on pituitary somatotrophs, thyrotrophs, and lactotrophs: pharmacological evidence for loose coupling to adenylate cyclase.
Somatostatin sst5 inhibition of receptor mediated regeneration of rat aortic vascular smooth muscle cells.
Somatostatin stimulates BKCa channels in rat pituitary tumor cells through lipoxygenase metabolites of arachidonic acid.
Somatostatin, misoprostol and galanin inhibit gastrin- and PACAP-stimulated secretion of histamine and pancreastatin from ECL cells by blocking specific Ca2+ channels.
Somatostatin-14 and somatostatin-28 induce opposite effects on potassium currents in rat neocortical neurons.
Somatostatin-14 blocks the hepatotrophic effects of insulin in the rat.
Somatostatin-induced control of cytosolic free calcium in pituitary tumour cells.
Somatostatin-induced inhibition of neurotransmission in the mouse isolated vas deferens is resistant to pertussis toxin.
Somatostatin-induced paradoxical increase in intracellular Ca2+ concentration and insulin release in the presence of arginine vasopressin in clonal HIT-T15 beta-cells.
Somatostatin5 receptor-mediated [35S]guanosine-5'-O-(3-thio)triphosphate binding: agonist potencies and the influence of sodium chloride on intrinsic activity.
Some changes of receptor and postreceptor signal transduction regulated by somatostatin in pituitary hGH-secreting adenomas.
Some new insights into the effects of opioids in phasic and tonic nociceptive tests.
Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores.
Sonic hedgehog enhances calcium oscillations in hippocampal astrocytes.
Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase.
SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines.
Special AT-rich sequence binding protein 1 is required for maintenance of T cell receptor responsiveness and development of experimental autoimmune encephalomyelitis.
Species differences in actions of islet-activating protein, pertussis toxin.
Specific alpha 1-adrenergic receptor subtypes modulate catecholamine-induced increases and decreases in ventricular automaticity.
Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart.
Specific binding of proinsulin C-peptide to human cell membranes.
Specific Gq protein involvement in muscarinic M3 receptor-induced phosphatidylinositol hydrolysis and Ca2+ release in mouse duodenal myocytes.
Specific identification of Bordetella pertussis by the polymerase chain reaction.
Specific immunoglobulin A to Bordetella pertussis antigens in mucosal secretion for rapid diagnosis of whooping cough.
Specific inhibition of FSH-stimulated cAMP accumulation by delta 9-tetrahydrocannabinol in cultures of rat Sertoli cells.
Specific involvement of G(alphai2) with epidermal growth factor receptor signaling in rat hepatocytes, and the inhibitory effect of chronic ethanol.
Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions.
Specific lung mucosal and systemic immune responses after oral immunization of mice with Salmonella typhimurium aroA, Salmonella typhi Ty21a, and invasive Escherichia coli expressing recombinant pertussis toxin S1 subunit.
Specific receptor-guanine nucleotide binding protein interaction mediates the release of endothelium-derived relaxing factor.
Specific roles of Gi protein family members revealed by dissecting somatostatin receptor 5 (SST5) coupling in human pituitary cells.
Specific T cell deletion by transfected human monocytes expressing fas ligand and antigen.
Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.
Specificity and detection limit of a dermal temperature histamine sensitization test for absence of residual pertussis toxin in vaccines.
Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides.
Specificity and sensitivity of high levels of immunoglobulin G antibodies against pertussis toxin in a single serum sample for diagnosis of infection with Bordetella pertussis.
Specificity of coupling of muscarinic receptor isoforms to a novel chick inward-rectifying acetylcholine-sensitive K+ channel.
Specificity of metabotropic glutamate receptor 2 coupling to G proteins.
Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system.
Spermatozoa contain a guanine nucleotide-binding protein ADP-ribosylated by pertussis toxin.
Spheroid formation and invasion capacity are differentially influenced by co-cultures of fibroblast and macrophage cells in breast cancer.
Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility.
Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases.
Sphingosine 1-phosphate activates Erk-1/-2 by transactivating epidermal growth factor receptor in rat-2 cells.
Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet beta-cells.
Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells.
Sphingosine 1-phosphate and control of vascular tone.
Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63.
Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kinase.
Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation.
Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses.
Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors.
Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase.
Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells.
Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells.
Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells.
Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis.
Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII.
Sphingosine 1-phosphate inhibits nitric oxide production induced by interleukin-1beta in rat vascular smooth muscle cells.
Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.
Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation.
Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells.
Sphingosine 1-phosphate mobilizes sequestered calcium, activates calcium entry, and stimulates deoxyribonucleic acid synthesis in thyroid FRTL-5 cells.
Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive.
Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production.
Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism.
Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor.
Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation.
Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells.
Sphingosine 1-phosphate receptors mediate the lipid-induced cAMP accumulation through cyclooxygenase-2/prostaglandin I2 pathway in human coronary artery smooth muscle cells.
Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin-insensitive manner.
Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor.
SPHINGOSINE 1-PHOSPHATE REGULATION OF EXTRACELLULAR SIGNAL REGULATED KINASE-1/2 IN EMBYRONIC STEM CELLS.
Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis.
Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis.
Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration.
Sphingosine 1-phosphate stimulates hydrogen peroxide generation through activation of phospholipase C-Ca2+ system in FRTL-5 thyroid cells: possible involvement of guanosine triphosphate-binding proteins in the lipid signaling.
Sphingosine 1-phosphate stimulates insulin secretion in HIT-T 15 cells and mouse islets.
Sphingosine 1-phosphate stimulates Na+/H+ exchange in thyroid FRTL-5 cells.
Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3.
Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway.
Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase.
Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation.
Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts.
Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.
Sphingosine 1-phosphate-induced signal transduction in cat esophagus smooth muscle cells.
Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: Regulation of synovial proliferation and inflammatory gene expression.
Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion.
Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB.
Sphingosine Kinase 1/S1P Pathway Involvement in the GDNF-Induced GAP43 Transcription.
Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells.
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.
Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells.
Sphingosine kinase-dependent directional migration of leukocytes in response to phorbol ester.
Sphingosine mobilizes intracellular calcium in human neutrophils.
Sphingosine-1-phosphate activates BKCa channels independently of G protein-coupled receptor in human endothelial cells.
Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor.
Sphingosine-1-phosphate activates the AKT pathway to inhibit chemotherapy induced human granulosa cell apoptosis.
Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis.
Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene.
Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.
Sphingosine-1-phosphate and lysophosphatidic acid stimulate endothelial cell migration.
Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro.
Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E2 from human articular chondrocytes.
Sphingosine-1-phosphate effects on PKC isoform expression in human osteoblastic cells.
Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice.
Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis.
Sphingosine-1-phosphate induces early response gene expression in C6 glioma cells.
Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades.
Sphingosine-1-phosphate inhibition of apoptosis requires mitogen-activated protein kinase phosphatase-1 in mouse fibroblast C3H10T 1/2 cells.
Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a G(i)-coupled receptor response.
Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation.
Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway.
Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through G(i)-protein-coupled receptors.
Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytes.
Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways.
Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival.
Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner.
Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in vascular smooth muscle cells.
Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways.
Sphingosine-1-phosphate stimulates cortisol secretion.
Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta.
Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation.
Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation.
Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation.
Sphingosine-mediated phosphatidylinositol metabolism and calcium mobilization.
Sphingosylphosphorylcholine activates Gq, Gi-2, and Gi-3 in thyroid FRTL-5 cells: implications for the activation of calcium fluxes and Na+-H+ exchange.
Sphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein.
Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilize cytosolic calcium through different mechanisms in human airway epithelial cells.
Sphingosylphosphorylcholine blocks ovariectomy-induced bone loss by suppressing Ca2+ /calmodulin-mediated osteoclast differentiation.
Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C.
Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.
Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism.
Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK.
Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation.
Sphingosylphosphorylcholine stimulates contraction of fibroblast-embedded collagen gel.
Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway.
Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry.
Spider toxin and pertussis toxin differentiate post- and presynaptic glutamate receptors.
Spinal ?-adrenergic receptors' activation increases the blood glucose level in mice.
Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.
Spinal and supraspinal effects of pertussis toxin on opioid analgesia.
Spinal morphine/clonidine antinociceptive synergism: involvement of G proteins and N-type voltage-dependent calcium channels.
Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation.
Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.
Spontaneous activity in transgenic mouse heart: comparison of primary atrial tumor with cultured AT-1 atrial myocytes.
Spontaneous and drug-stimulated locomotor activity after the administration of pertussis toxin into the ventral tegmental area.
Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions.
Spontaneous cytosolic calcium pulsing detected in Xenopus melanotrophs: modulation by secreto-inhibitory and stimulant ligands.
Spontaneous induction of immunoregulation by an endogenous retinal antigen.
Spontaneous phase variation in Bordetella pertussis is a multistep non-random process.
Spotlight on Tdap? vaccine (Covaxis®) as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis: in children (aged ?4 years), adolescents, and adults.
Spp24 derivatives stimulate a gi -protein coupled receptor-erk1/2 signaling pathway and modulate gene expressions in w-20-17 cells.
SR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist.
SR144528 as inverse agonist of CB2 cannabinoid receptor.
Src kinase mediates angiotensin II-dependent increase in pulmonary endothelial nitric oxide synthase.
Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells.
Src-regulated extracellular signal-related kinase and Syk-regulated c-Jun N-terminal kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells.
Stability of antibodies to Bordetella antigens in German adults.
Stabilization of the pertussis toxin secretion apparatus by the C terminus of PtlD.
Stable expression of pertussis toxin in Bordetella bronchiseptica under the control of a tightly regulated promoter.
Stable guanosine 5'-triphosphate-analogues inhibit specific (+)-[3H]isradipine binding in rat hearts by a Ca(2+)-lowering, G protein-independent mechanism.
Stable inhibition of adenylate cyclase by muscarinic agonist in rat parotid gland: effects of neomycin and pertussis toxin.
Stable transfection of the rat follicle-stimulating hormone receptor complementary DNA into an immortalized murine Sertoli cell line.
Standardization of acellular pertussis vaccine by assay of serum neutralizing antibodies to pertussis toxin (antitoxin): analogy with diphtheria toxoid.
Staphylococcus albus-induced protein kinase C translocation in human neutrophils: the effect of opsonization, cytochalasin B, pertussis toxin, intra- and extracellular calcium, and R59022.
STAT5A interacts with and is phosphorylated upon activation of the mu-opioid receptor.
Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms.
Staurosporine clamps cytosolic free Ca2+ concentrations of human neutrophils.
Steady and transient fluid shear stress stimulate NO release in osteoblasts through distinct biochemical pathways.
Stearate inhibition of breast cancer cell proliferation. A mechanism involving epidermal growth factor receptor and G-proteins.
Stem cell factor influences neuro-immune interactions: the response of mast cells to pituitary adenylate cyclase activating polypeptide is altered by stem cell factor.
Stem cell factor potentiates histamine secretion by multiple mechanisms, but does not affect tumour necrosis factor-alpha release from rat mast cells.
Stepwise activation of the gonadotropic signal transduction pathway, and the ability of prostaglandin F2alpha to inhibit this activated pathway.
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes.
Steroid treatments in mice do not alter the number and function of regulatory T cells, but amplify cyclophosphamide-induced autoimmune disease.
Steroid-sensitivity of agonist binding to pituitary cell line histamine H3 receptors.
Stimulating properties of 5-oxo-eicosanoids for human monocytes: synergism with monocyte chemotactic protein-1 and -3.
Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins.
Stimulation and inhibition of cAMP accumulation by glucagon in canine hepatocytes.
Stimulation and inhibition of rat basophilic leukemia cell adenylate cyclase by forskolin.
Stimulation by endothelin-1 of mitogen-activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells.
Stimulation by extracellular ATP and UTP of the stress-activated protein kinase cascade in rat renal mesangial cells.
Stimulation by leukotriene D4 of increases in the cytosolic concentration of calcium in dimethylsulfoxide-differentiated HL-60 cells.
Stimulation by the nucleotides, ATP and UTP of mitogen-activated protein kinase in EAhy 926 endothelial cells.
Stimulation by tumor necrosis factor of HL-60 thymidine salvage pathway metabolism dissociated from proliferation.
Stimulation of a Gs-like G protein in the osteoclast inhibits bone resorption but enhances tartrate-resistant acid phosphatase secretion.
Stimulation of a histone H4 protein kinase in Triton X-100 lysates of rabbit peritoneal neutrophils pretreated with chemotactic factors: lack of requirements of calcium mobilization and protein kinase C activation.
Stimulation of adenosine A1 receptors and bradykinin receptors, which act via different G proteins, synergistically raises inositol 1,4,5-trisphosphate and intracellular free calcium in DDT1 MF-2 smooth muscle cells.
Stimulation of adenosine receptor enhances alpha 1-adrenergic receptor-mediated activation of phospholipase C and Ca2+ mobilization in a pertussis toxin-sensitive manner in FRTL-5 thyroid cells.
Stimulation of alpha 2 adrenoceptors dilates the rat middle cerebral artery.
Stimulation of arachidonic acid release by guanine nucleotide in saponin-permeabilized neutrophils: evidence for involvement of GTP-binding protein in phospholipase A2 activation.
Stimulation of beta(3)-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes.
Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins.
Stimulation of cannabinoid receptor agonist 2-arachidonylglycerol by chronic ethanol and its modulation by specific neuromodulators in cerebellar granule neurons.
Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells.
Stimulation of cardiac alpha receptors increases Na/K pump current and decreases gK via a pertussis toxin-sensitive pathway.
Stimulation of cell proliferation by calcium and a calcimimetic compound.
Stimulation of cortisol production through angiotensin AT2 receptors in bovine fasciculata cells.
Stimulation of cyclic adenosine 3',5'-monophosphate production enhances hypothalamic luteinizing hormone-releasing hormone release without increasing prostaglandin E2 synthesis: studies in prepubertal female rats.
Stimulation of cyclic AMP production by the Caenorhabditis elegans muscarinic acetylcholine receptor GAR-3 in Chinese hamster ovary cells.
Stimulation of DNA synthesis in Jurkat cells by synergistic action between adenine and guanine nucleotides.
Stimulation of early gene induction and cell proliferation by lysophosphatidic acid in human amnion-derived WISH cells: role of phospholipase D-mediated pathway.
Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin.
Stimulation of generation of inositol phosphates by carbamoylcholine and its inhibition by phorbol esters and iodide in dog thyroid cells.
Stimulation of glucose incorporation into glycogen by E-series prostaglandins in cultured rat hepatocytes.
Stimulation of glycogen degradation by prostaglandin E2 in primary cultured rat hepatocytes.
Stimulation of glycogenolysis by three locust adipokinetic hormones involves Gs and cAMP.
Stimulation of Gs and inhibition of Gi protein functions by minimally oxidized LDL.
Stimulation of guanosine 5'-O-(3-[35S] thiotriphosphate) binding by cholinergic muscarinic receptors in membranes of rat olfactory bulb.
Stimulation of high-affinity GTPase activity and cholera toxin-catalysed [32P]ADP-ribosylation of Gi by lysophosphatidic acid (LPA) in wild-type and alpha 2C10 adrenoceptor-transfected Rat 1 fibroblasts.
Stimulation of histamine H2- (and H1)-receptors activates Ca2+ influx in all-trans-retinoic acid-differentiated HL-60 cells independently of phospholipase C or adenylyl cyclase.
Stimulation of HIV gp120-specific cytolytic T lymphocyte responses in vitro and in vivo using a detoxified pertussis toxin vector.
Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase gamma.
Stimulation of human thyroid growth via the inhibitory guanine nucleotide binding (G) protein Gi: constitutive expression of the G-protein alpha subunit Gi alpha-1 in autonomous adenoma.
Stimulation of hypothalamic opioid peptide release by lithium is mediated by opioid autoreceptors: evidence from a combined in vitro, ex vivo study.
Stimulation of inositol phosphate formation in FRTL-5 rat thyroid cells by catecholamines and its relationship to changes in 45Ca2+ efflux and cyclic AMP accumulation.
Stimulation of inositol phosphate production by neurotensin in neuroblastoma N1E115 cells: implication of GTP-binding proteins and relationship with the cyclic GMP response.
Stimulation of intracellular calcium concentration by adenosine triphosphate and uridine 5'-triphosphate in human term placental cells: evidence for purinergic receptors.
Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors.
Stimulation of intracellular topoisomerase I activity by vasopressin and thrombin. Differential regulation by pertussis toxin.
Stimulation of luteinizing hormone (LH) release and phospholipid breakdown by guanosine triphosphate in permeabilized pituitary gonadotropes: antagonist action suggests association of a G protein and gonadotropin-releasing hormone receptor.
Stimulation of luteinizing hormone release by sodium fluoride is independent of protein kinase-C activity and unaffected by desensitization to gonadotropin-releasing hormone.
Stimulation of macrophage colony-stimulating factor synthesis by interleukin-1.
Stimulation of mitogen activated protein kinase by LDL and oxLDL in human U-937 macrophage-like cells.
Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone in human granulosa-luteal cells.
Stimulation of mitogen-activated protein kinase by thyrotropin in astrocytes.
Stimulation of mitogen-activated protein kinase by thyrotropin in primary cultured human thyroid follicles.
Stimulation of mono-ADP ribosylation in rat liver plasma membranes after long-term alcohol intake.
Stimulation of mu- and delta-opioid receptors enhances phosphoinositide metabolism in mouse spinal cord: evidence for subtypes of delta-receptors.
Stimulation of mucosal and systemic antibody responses against Bordetella pertussis filamentous haemagglutinin and recombinant pertussis toxin after nasal administration with chitosan in mice.
Stimulation of muscarinic M2 receptors inhibits atrial natriuretic peptide-mediated relaxation in bovine tracheal smooth muscle.
Stimulation of naïve T-cell adhesion and immunological synapse formation by chemokine-dependent and -independent mechanisms.
Stimulation of neutrophil leukocyte chemotaxis by a cloned cytolytic enterotoxin of Aeromonas hydrophila.
Stimulation of neutrophils with a chemoattractant activates several novel protein kinases that can catalyze the phosphorylation of peptides derived from the 47-kDa protein component of the phagocyte oxidase and myristoylated alanine-rich C kinase substrate.
Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils.
Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60.
Stimulation of peripheral nociceptor endings by low dose morphine and its signaling mechanism.
Stimulation of Phospholipase A(2) by Toxic Main Group Heavy Metals: Partly Dependent on G-proteins?
Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.
Stimulation of phospholipase C-mediated hydrolysis of phosphoinositides by adenosine 5'-triphosphate via P2-purinoceptors in cultured rat aortic vascular smooth muscle cells.
Stimulation of phospholipase D activity by oxidized LDL in mouse peritoneal macrophages.
Stimulation of protein kinase B and p70 S6 kinase by the histamine H1 receptor in DDT1MF-2 smooth muscle cells.
Stimulation of rat pancreatic tumoral AR4-2J cell proliferation by pituitary adenylate cyclase-activating peptide.
Stimulation of reactive oxidant production in neutrophils by soluble and insoluble immune complexes occurs via different receptors/signal transduction systems.
Stimulation of respiratory burst by cyclocommunin in rat neutrophils is associated with the increase in cellular Ca2+ and protein kinase C activity.
Stimulation of sodium-dependent inorganic phosphate transport by activation of Gi/o-protein-coupled receptors by epinephrine in MC3T3-E1 osteoblast-like cells.
Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation.
Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway.
Stimulation of T-Cell activation by CXCL12/stromal cell derived factor-1 involves a G-protein mediated signaling pathway.
Stimulation of the extracellular signal-regulated kinase 1/2 pathway by human beta-3 adrenergic receptor: new pharmacological profile and mechanism of activation.
Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells.
Stimulation of the T-cell receptors CD3 and CD2 with OKT3 and OKT11 antibodies activates a common pertussis toxin-insensitive G-protein.
Stimulation of the thiol-dependent ADP-ribosyltransferase and NAD glycohydrolase activities of Bordetella pertussis toxin by adenine nucleotides, phospholipids, and detergents.
Stimulation of type II adenylyl cyclase by chemoattractant formyl peptide and C5a receptors.
Stimulations of arachidonate release and inositol-1,4,5-triphosphate formation are mediated by distinct G-proteins in human platelets.
Stimulatory and inhibitory actions of carbachol on chloride secretory responses in human colonic cell line T84.
Stimulatory and inhibitory actions of lysophosphatidylcholine, depending on its fatty acid residue, on the phospholipase C/Ca2+ system in HL-60 leukaemia cells.
Stimulatory and inhibitory guanine-nucleotide-binding regulatory protein involvement in stimulation of arachidonic-acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea-pig alveolar macrophages. Differential receptor/G-protein interaction assessed by pertussis and cholera toxins.
Stimulatory effect of guanine nucleotides on prostaglandin E1 binding to murine renal outer medulla.
Stimulatory effect of insulin and insulin-like growth factor I on Gi proteins and angiotensin-II-induced phosphoinositide breakdown in cultured bovine adrenal cells.
Stimulatory effect of pertussis toxin on tissue cyclic AMP levels in canine thyroid slices.
Stimulatory effects of histamine on migration of nasal fibroblasts.
Stimulatory effects of lipoprotein(a) and low-density lipoprotein on human umbilical vein endothelial cell migration and proliferation are partially mediated by fibroblast growth factor-2.
Stimulatory effects of quinpirole hydrochloride, D2-dopamine receptor agonist, at low concentrations on prolactin release in female rats in vitro.
Stimulatory pathways of the Calcium-sensing receptor on acid secretion in freshly isolated human gastric glands.
Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells.
Stimulus-dependent transduction mechanisms for nitric oxide release in human polymorphonuclear neutrophil leukocytes.
Stimulus-induced dissociation of alpha subunits of heterotrimeric GTP-binding proteins from the cytoskeleton of human neutrophils.
Stimulus-response coupling in a cell-free platelet membrane system. GTP-dependent release of Ca2+ by thrombin, and inhibition by pertussis toxin and a monoclonal antibody that blocks calcium release by IP3.
Stimulus-response coupling in FMLP-stimulated U937 monocytes: effect of differentiation on Gi2 expression.
Stimulus-response coupling in monocytes infected with Leishmania. Attenuation of calcium transients is related to defective agonist-induced accumulation of inositol phosphates.
Stomatal Opening Is Induced in Epidermal Peels of Commelina communis L. by GTP Analogs or Pertussis Toxin.
Storage at -3 degrees C for 24 h alters the immunogenicity of pertussis vaccines.
Store-activated Ca2+ inflow in Xenopus laevis oocytes: inhibition by primaquine and evaluation of the role of membrane fusion.
Store-operated Ca(2+) inflow in Reuber hepatoma cells is inhibited by voltage-operated Ca(2+) channel antagonists and, in contrast to freshly isolated hepatocytes, does not require a pertussis toxin-sensitive trimeric GTP-binding protein.
Strain variation among Bordetella pertussis isolates in finland, where the whole-cell pertussis vaccine has been used for 50 years.
Strategies to alleviate original antigenic sin responses to influenza viruses.
Streptococcal glycoprotein-induced tumour cell growth inhibition involves the modulation of a pertussis toxin-sensitive G protein.
Stress and glucocorticoids impair memory retrieval via ?2-adrenergic, Gi/o-coupled suppression of cAMP signaling.
Stretch-induced inositol trisphosphate and tetrakisphosphate production in rat cardiomyocytes.
Stretching increases calcium influx and efflux in cultured pulmonary arterial smooth muscle cells.
Stromal Cell-Derived Factor 1 Increases Tetrodotoxin-Resistant Sodium Currents Nav1.8 and Nav1.9 in Rat Dorsal Root Ganglion Neurons via Different Mechanisms.
Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells.
Stromal cell-derived factor 1alpha activates LIM kinase 1 and induces cofilin phosphorylation for T-cell chemotaxis.
Stromal cell-derived factor-1 alpha and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis.
Stromal cell-derived factor-1/CXCL12 stimulates chemorepulsion of NOD/LtJ T-cell adhesion to islet microvascular endothelium.
Stromal cell-derived factor-1alpha directly modulates voltage-dependent currents of the action potential in mammalian neuronal cells.
Stromal cell-derived factor-1alpha induces astrocyte proliferation through the activation of extracellular signal-regulated kinases 1/2 pathway.
Stromal cell-derived factor-1alpha induces tube-like structure formation of endothelial cells through phosphoinositide 3-kinase.
Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine receptors.
Strontium and barium induce exocytosis in electropermeabilized neutrophils.
Structural and functional analysis of the S1 subunit of pertussis toxin using synthetic peptides.
Structural and functional attributes of zona pellucida glycoproteins.
Structural and functional relationships of guanosine triphosphate binding proteins.
Structural and functional studies of cross-linked Go protein subunits.
Structural and functional studies on the G(o) protein.
Structural basis of G protein specificity of human endothelin receptors. A study with endothelinA/B chimeras.
Structural characterization of pertussis toxin A subunit.
Structural evidence for the evolution of pyrogenic toxin superantigens.
Structural relationship between the S1 and S4 subunits of pertussis toxin.
Structural requirements for G(o) activation by receptor-derived peptides: activation and modulation domains of the alpha 2-adrenergic receptor i3c region.
Structural requirements for neuropeptide Y in mast cell and G protein activation.
Structural requirements of platelet chemokines for neutrophil activation.
Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades.
Structure and compositional analysis of aluminum oxyhydroxide adsorbed pertussis vaccine.
Structure and stability of pertussis toxin studied by in situ atomic force microscopy.
Structure of a pertussis toxin-sugar complex as a model for receptor binding.
Structure-activity analysis of the activation of pertussis toxin.
Structure-activity relationship and signal transduction of gamma-MSH peptides in GH3 cells: further evidence for a new melanocortin receptor.
Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells.
Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins.
Structure-function analysis of Frizzleds.
Structure-function relationship of islet-activating protein, pertussis toxin: biological activities of hybrid toxins reconstituted from native and methylated subunits.
Structure-function relationships among human cathelicidin peptides: dissociation of antimicrobial properties from host immunostimulatory activities.
Structure/function relationships of calcitonin analogues as agonists, antagonists, or inverse agonists in a constitutively activated receptor cell system.
Studies of melatonin effects on epithelia using the human embryonic kidney-293 (HEK-293) cell line.
Studies of signal transduction in the respiratory burst-associated stimulation of fMet-Leu-Phe-induced tubulin tyrosinolation and phorbol 12-myristate 13-acetate-induced posttranslational incorporation of tyrosine into multiple proteins in activated neutrophils and HL-60 cells.
Studies of the antigenic structure of two cross-reacting proteins, pertussis and cholera toxins, using synthetic peptides.
Studies of the cellular mechanisms underlying the vasorelaxant effects of rutaecarpine, a bioactive component extracted from an herbal drug.
Studies of the renal action of melatonin: evidence that the effects are mediated by 37 kDa receptors of the Mel1a subtype localized primarily to the basolateral membrane of the proximal tubule.
Studies on molecular regulation of phagocytosis in neutrophils. Con A-mediated ingestion and associated respiratory burst independent of phosphoinositide turnover, rise in [Ca2+]i, and arachidonic acid release.
Studies on nucleotide and receptor regulation of Gi proteins: effects of pertussis toxin.
Studies on opsonized zymozan, FMLP, carbachol, PMA and A23187 stimulated respiratory burst of human PMNLs.
STUDIES ON PERTUSSIS TOXIN.
Studies on phase variation in Bordetella pertussis.
Studies on primed precursors of effector T cells involved in delayed-type hypersensitivity to sheep red blood cells in mice.
Studies on prn variation in the mouse model and comparison with epidemiological data.
Studies on pyrazinoylguanidine. 3. Downregulation of lipolysis in isolated adipocytes.
Studies on the activation of human neutrophil 5-lipoxygenase induced by natural agonists and Ca2+ ionophore A23187.
Studies on the cell-cycle dependency of the actions of insulin-like growth factor-I in Balb/c 3T3 cells.
Studies on the characterization of the subtype(s) of muscarinic receptor involved in prostacyclin synthesis in rabbit cardiomyocytes.
Studies on the lymphocytosis induced by pertussis toxin.
Studies on the mechanism of desensitization of the cyclic AMP response to TSH stimulation in a cloned rat thyroid cell line.
Studies on the mechanism of uptake of low density lipoprotein-proteoglycan complex in macrophages.
Studies on the mechanisms of signalling and inhibition by pertussis toxin of fibroblast growth factor-stimulated mitogenesis in Balb/c 3T3 cells.
Study of the activation mechanism of adriamycin on rat mast cells.
Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release.
Study of the functional organization of a novel adenylate cyclase signaling mechanism of insulin action.
Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein.
Study protocol of the PIMPI-project, a cohort study on acceptance, tolerability and immunogenicity of second trimester maternal pertussis immunization in relation to term and preterm infants.
Subcellular distribution and characterization of GTP-binding proteins in human neutrophils.
Subcellular distribution and membrane association of human neutrophil substrates for ADP-ribosylation by pertussis toxin and cholera toxin.
Subcellular localization and kinetic characterization of guanine nucleotide binding proteins in normal rat and human pancreatic islets and transformed beta cells.
Subcellular localization and quantitation of the major neutrophil pertussis toxin substrate, Gn.
Subcellular localization of Gi alpha in human neutrophils.
Subcellular mechanisms of angiotensin II and arginine vasopressin activation of area postrema neurons.
Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors.
Subclass compositions of immunoglobulin G to pertussis toxin in patients with whooping cough, in healthy individuals, and in recipients of a pertussis toxoid vaccine.
Subclinical pertussis in incompletely vaccinated and unvaccinated infants.
Subcutaneous administration of a fusion protein composed of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis induces mucosal and systemic immune responses.
Subcutaneous Immunization with Recombinant Lactococcus lactis Expressing F1S1 Fusion Protein Induces Systemic and Mucosal Immune Responses in BALB/C Mice.
Submandibular enzymatic vasoconstrictor increases DNA and phosphoinositol synthesis by mesenchymal cells.
Substance P activates the release of histamine from human skin mast cells through a pertussis toxin-sensitive and protein kinase C-dependent mechanism.
Substance P and somatostatin inhibit calcium channels in rat sympathetic neurons via different G protein pathways.
Substance P modulates sensory action potentials in the lamprey via a protein kinase C-mediated reduction of a 4-aminopyridine-sensitive potassium conductance.
Substance P stimulation of polyphosphoinositide hydrolysis in rat anterior pituitary membranes involves a GTP-dependent mechanism.
Substance P suppresses GABAA receptor function via protein kinase C in primary sensory neurones of bullfrogs.
Substance P-induced activation of p42/44 mitogen-activated protein kinase associated with cell proliferation in human tracheal smooth muscle cells.
Substance P-related inhibitors of mast cell exocytosis act on G-proteins or on the cell surface.
Substantial gaps in knowledge of Bordetella pertussis antibody and T cell epitopes relevant for natural immunity and vaccine efficacy.
Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes.
Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells.
Subtype-specific increase in G-protein alpha-subunit mRNA by interleukin 1 beta.
Subtype-specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2.
Subtypes of adrenergic receptors and intracellular mechanisms involved in modulatory effects of noradrenaline on glutamate.
Subtypes of Guanine-Nucleotide-Binding Regulatory Proteins at the Locus coeruleus Involved in Fentanyl-Induced Muscular Rigidity in the Rat.
Subunit interactions of native and ADP-ribosylated alpha 39 and alpha 41, two guanine nucleotide-binding proteins from bovine cerebral cortex.
Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity.
Subunit structure and enzymic activity of pertussis toxin.
Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model.
Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C.
Succinate receptor GPR91, a G?(i) coupled receptor that increases intracellular calcium concentrations through PLC?.
Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-alpha and interleukin-8 mRNA in human neutrophils. Evidence for a role of L-selectin as a signaling molecule.
Sulfhydryl G proteins and phospholipase A(2)-associated G proteins are involved in adrenergic signal transduction in the rat pineal gland.
Sulfhydryl-alkylating reagents inactivate the NAD glycohydrolase activity of pertussis toxin.
Sulfite induces adherence of polymorphonuclear neutrophils to immobilized fibrinogen through activation of Mac-1 beta2-integrin (CD11b/CD18).
Superoxide production from human polymorphonuclear leukocytes by human mannan-binding protein (MBP).
Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways.
Supersensitivity of isolated atria from diabetic rats to adenosine and methacholine: modulation by pertussis toxin.
Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits.
Supersensitization of the adenylyl cyclase system in Chinese hamster ovary cells co-expressing cloned opioid receptors and Gz, a PTX-insensitive G protein.
Suppressing effect of pertussis toxin on clonidine-induced inhibition of noradrenaline release from cerebral cortical slices of rats.
Suppression of a nonselective cation conductance by substance P in cochlear outer hair cells.
Suppression of cAMP by phosphoinositol/Ca2+ pathway in the cardiac kappa-opioid receptor.
Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway.
Suppression of cytoskeletal rearrangement in activated human neutrophils by botulinum C2 toxin. Impact on cellular signal transduction.
Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration.
Suppression of kindled seizure following intraamygdaloid injection of pertussis toxin in rats.
Suppression of lymphocyte adenosine 3':5'-cyclic monophosphate (cAMP) by delta-9-tetrahydrocannabinol.
Suppression of passive cutaneous anaphylaxis by pertussis toxin, an islet-activating protein, as a result of inhibition of histamine release from mast cells.
Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein.
Suppression of the carbachol-activated nonselective cationic current by antibody against alpha subunit of Go protein in guinea-pig gastric myocytes.
Suppression of the cytotoxic T-lymphocyte response in mice by pertussis toxin.
Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism.
Suppression of the Peripheral Immune System Limits the Central Immune Response Following Cuprizone-Feeding: Relevance to Modelling Multiple Sclerosis.
Suppression of the voltage-gated K+ current of human megakaryocytes by thrombin and prostacyclin.
Suramin has adjuvant properties and promotes expansion of antigen-specific Th1 and Th2 cells in vivo.
Surface expression of a protective recombinant pertussis toxin S1 subunit fragment in Streptococcus gordonii.
Surface proteins of Bordetella pertussis.
Surface proteins of Bordetella pertussis: comparison of virulent and avirulent strains and effects of phenotypic modulation.
Survey of pertussis in patients with prolonged cough.
Sustained activation of phospholipase D via adenosine A3 receptors is associated with enhancement of antigen- and Ca(2+)-ionophore-induced secretion in a rat mast cell line.
Sustained efficacy during the first 6 years of life of 3-component acellular pertussis vaccines administered in infancy: the Italian experience.
Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells.
Swimming behavior regulation by GABAB receptors in Paramecium.
Sympathetic denervation-induced changes in G protein expression in enteric neurons of the guinea pig colon.
Sympathetic neural and alpha-adrenergic modulation of arrhythmias.
Sympathetic--parasympathetic interaction and sudden death.
Synergic effect of genotype changes in pertussis toxin and pertactin on adaptation to an acellular pertussis vaccine in the murine intranasal challenge model.
Synergism among lysophosphatidic acid, beta1A integrins, and epidermal growth factor or platelet-derived growth factor in mediation of cell migration.
Synergism in cytosolic Ca2+ mobilization between bradykinin and agonists for pertussis toxin-sensitive G-protein-coupled receptors in NG 108-15 cells.
Synergistic binding of RNA polymerase and BvgA phosphate to the pertussis toxin promoter of Bordetella pertussis.
Synergistic BM-DC activation and immune induction by the oral vaccine vector Streptococcus gordonii and exogenous tumor necrosis factor.
Synergistic effects of ATP on oxytocin-induced intracellular Ca2+ response in mouse mammary myoepithelial cells.
Synergistic increase in Ca2+ produced by A1 adenosine and muscarinic receptor activation via a pertussis-toxin-sensitive pathway in epithelial cells of the rabbit ciliary body.
Synergistic interaction of morphine and halothane in the guinea pig ileum: effects of pertussis toxin.
Synergistic interaction of muscarinic and opioid receptors with GS-linked neurotransmitter receptors to stimulate adenylyl cyclase activity of rat olfactory bulb.
Synergistic interaction of Y1-neuropeptide Y and alpha 1b-adrenergic receptors in the regulation of phospholipase C, protein kinase C, and arachidonic acid production.
Synergistic neutralization of pertussis toxin by a bispecific antibody in vitro and in vivo.
Synergistic regulation of cytosolic Ca2+ concentration in mouse astrocytes by NK1 tachykinin and adenosine agonists.
Synergistic rise in Ca2+ produced by somatostatin and acetylcholine in ciliary body epithelial cells.
Synergistic stimulation of airway smooth muscle cell mitogenesis.
Synergistic teratogenic effect produced in mice by whole cell pertussis vaccine.
Synergy between phorbol esters, 1-oleyl-2-acetylglycerol, urushiol, and calcium ionophore in eliciting aggregation of marine sponge cells.
Synergy between the inositol phosphate responses to transfected human adenosine A1-receptors and constitutive P2-purinoceptors in CHO-K1 cells.
Synthesis and characterization of a Pertussis toxin-biotin conjugate.
Synthesis and characterization of fluorescently labeled bovine brain G protein subunits.
Synthesis of a conjugate vaccine composed of pneumococcus type 14 capsular polysaccharide bound to pertussis toxin.
Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins.
Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin-Deficient Cells.
Systemic allergic reactions to gelatin included in vaccines as a stabilizer.
Systemic exposure to a single dose of ferucarbotran aggravates neuroinflammation in a murine model of experimental autoimmune encephalomyelitis.
Systemic Mesenchymal Stem Cell Treatment Mitigates Structural and Functional Retinal Ganglion Cell Degeneration in a Mouse Model of Multiple Sclerosis.
Systemic ocular antigen immunization leads only to a minor secondary immune response.
T cell activation via the T cell receptor: a comparison between WT31 (defining alpha/beta TcR)-induced and anti-CD3-induced activation of human T lymphocytes.
T cell and chemokine receptors differentially control CD8 T cell motility behavior in the infected airways immediately before and after virus clearance in a primary infection.
T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis.
T cell lines specific for an immunodominant epitope of human basic protein define an encephalitogenic determinant for experimental autoimmune encephalomyelitis-resistant LOU/M rats.
T cell mechanisms in experimental autoimmune uveoretinitis: susceptibility is a function of the cytokine response profile.
T cell-derived suppressive activity: evidence of autocrine noncytolytic control of HIV type 1 transcription and replication.
T-cell immune response assessment as a complement to serology and intranasal protection assays in determining the protective immunity induced by acellular pertussis vaccines in mice.
Tachykinins cause inward current through NK1 receptors in bullfrog sensory neurons.
TAN-67, a delta 1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels.
Tannin stimulates arachidonic acid release from bovine tracheal epithelial cells.
Targeted inactivation of alphai2 or alphai3 disrupts activation of the cardiac muscarinic K+ channel, IK+Ach, in intact cells.
Targeting CLA/E-selectin interactions prevents CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo.
Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy.
Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies.
Targets for TNF-alpha-induced lipolysis in human adipocytes.
Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein.
Tax-inducible production of CC chemokine ligand 22 by human T cell leukemia virus type 1 (HTLV-1)-infected T cells promotes preferential transmission of HTLV-1 to CCR4-expressing CD4+ T cells.
Tdap booster to adolescents with juvenile idiopathic arthritis on and off anti-TNF agents is safe and immunogenic.
Tdap(5) vaccine (covaxis®): a review of its use as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis in children (aged ?4 years), adolescents, and adults.
Temperature-dependent stimulation and inhibition of adenylate cyclase by Aplysia bag cell peptides.
Temporal expression of pertussis toxin and Ptl secretion proteins by Bordetella pertussis.
Temporal nucleotide changes in pertactin and pertussis toxin genes in Bordetella pertussis strains isolated from clinical cases in Poland.
Temporal trends in circulating Bordetella pertussis strains in Australia.
Temporally Coarse-Grained All-Atom Molecular Dynamics Achieved via Stochastic Padé Approximants.
Terminal serotonin autoreceptor function in the rat hippocampus is not modified by pertussis and cholera toxins.
Testicular expression of Adora3i2 in Adora3 knockout mice reveals a role of mouse A3Ri2 and human A3Ri3 adenosine receptors in sperm.
Testing implications of varying targets for Bordetella pertussis: comparison of the FilmArray Respiratory Panel and the Focus B. pertussis PCR assay.
Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes.
Testosterone modulates K(+)ATP channels in sertoli cell membrane via the PLC-PIP2 pathway.
Testosterone rapidly increases Ca(2+)-activated K(+) currents causing hyperpolarization in human coronary artery endothelial cells.
Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages.
Testosterone stimulates intracellular calcium release and mitogen-activated protein kinases via a G protein-coupled receptor in skeletal muscle cells.
Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.
Tetrahydrocannabinol-induced apoptosis of cultured cortical neurones is associated with cytochrome c release and caspase-3 activation.
Tetrahydrocannabinol-induced neurotoxicity depends on CB1 receptor-mediated c-Jun N-terminal kinase activation in cultured cortical neurons.
TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis.
TGF-beta-induced G2/M delay in proliferating rabbit articular chondrocytes is associated with an enhancement of replication rate and a cAMP decrease: possible involvement of pertussis toxin-sensitive pathway.
Thapsigargin activates univalent- and bivalent-cation entry in human neutrophils by a SK&F I3 96365- and Gd3+-sensitive pathway and is a partial secretagogue: involvement of pertussis-toxin-sensitive G-proteins and protein phosphatases 1/2A and 2B in the signal-transduction pathway.
Thapsigargin and receptor-mediated activation of Drosophila TRPL channels stably expressed in a Drosophila S2 cell line.
The 112-Year Odyssey of Pertussis and Pertussis Vaccines-Mistakes Made and Implications for the Future.
The 20 kDa C-terminally truncated form of pertussis toxin subunit S1 secreted from Bacillus subtilis.
The 5-HT1D receptor antagonist GR-127,935 prevents inhibitory effects of sumatriptan but not CP-122,288 and 5-CT on neurogenic plasma extravasation within guinea pig dura mater.
The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor.
The 70-kilodalton pertussis toxin-binding protein in Jurkat cells.
The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein.
The action is at the terminal.
The action mode of lysophosphatidylcholine in human monocytes.
The action of 5-HT on calcium-dependent potassium channels and on the spinal locomotor network in lamprey is mediated by 5-HT1A-like receptors.
The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes.
The action of pertussis toxin on heart adenylate cyclase and lipolysis in the parametrial adipose tissue of the rat.
The actions of Pasteurella multocida toxin on neuronal cells.
The activation of ?2-adrenergic receptor in the spinal cord lowers sepsis-induced mortality.
The activation of human platelets mediated by anti-human platelet p24/CD9 monoclonal antibodies.
The activity of purified Bordetella pertussis components in murine encephalopathy.
The acute and chronic stimulatory effects of endothelin-1 on glucose transport are mediated by distinct pathways in 3T3-L1 adipocytes.
The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively.
The adenylyl cyclase-cyclic AMP system modulates morphological and functional development of hypothalamic beta-endorphin neurons in culture.
The adipocyte Go alpha-immunoreactive polypeptide is different from the alpha subunit of the brain Go protein.
The agonist effect of Bay K 8644 on neuronal calcium channel currents is promoted by G-protein activation.
The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs.
The amino terminus of G protein alpha subunits is required for interaction with beta gamma.
The anaphylatoxin C3a primes model colonic epithelial cells for expression of inflammatory mediators through G?i.
The angiotensin II type 2 receptor primarily inhibits cell growth via pertussis toxin-sensitive G proteins.
The anti-adrenergic effect of adenosine and its blockade by pertussis toxin: a comparative study in myocytes isolated from guinea-pig, rat and failing human hearts.
The anti-apoptotic activity associated with phosphatidylinositol transfer protein alpha activates the MAPK and Akt/PKB pathway.
The anti-apoptotic activity of albumin for endothelium is mediated by a partially cryptic protein domain and reduced by inhibitors of G-coupled protein and PI-3 kinase, but is independent of radical scavenging or bound lipid.
The anti-infective peptide, innate defense-regulator peptide, stimulates neutrophil chemotaxis via a formyl peptide receptor.
The antiadrenergic effect of neuropeptide Y on the ventricular cardiomyocyte.
The antiapoptotic effect of guanosine is mediated by the activation of the PI 3-kinase/AKT/PKB pathway in cultured rat astrocytes.
The antiarrhythmic action of ischaemic preconditioning in rat hearts does not involve functional Gi proteins.
The antiarrhythmic effect of ischaemic preconditioning in isolated rat heart involves a pertussis toxin sensitive mechanism.
The antibodies against Bordetella pertussis in sera of patients with Parkinson's disease and other non-neurological diseases.
The antineoplastic drug vinorelbine activates non-immunological histamine release from rat mast cells.
The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome.
The association of heterotrimeric GTP-binding protein (Go) with microtubules.
The atherogenic actions of LPC on vascular smooth muscle cells and its LPA receptor mediated mechanism.
The autotaxin-LPA2 GPCR axis is modulated by ?-irradiation and facilitates DNA damage repair.
The B subunit of an AB5 toxin produced by Salmonella enterica serovar Typhi up-regulates chemokines, cytokines, and adhesion molecules in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines.
The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains.
The B-oligomer of pertussis toxin inhibits human immunodeficiency virus type 1 replication at multiple stages.
The beneficial effects of 18?-glycyrrhetinic acid on the experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mouse model.
The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase.
The beta-amyloid precursor protein controls a store-operated Ca2+ entry in cortical neurons.
The Beta-Arrestin-Biased Dopamine D2 Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation.
The beta1-adrenergic receptor mediates extracellular signal-regulated kinase activation via Galphas.
The beta2-adrenergic receptor specifically sequesters Gs but signals through both Gs and Gi/o in rat sympathetic neurons.
The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.
The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor.
The beta6/alpha5 regions of Galphai2 and GalphaoA increase the promiscuity of Galpha16 but are insufficient for pertussis toxin-catalyzed ADP-ribosylation.
The binding subunit of pertussis toxin inhibits HIV replication in human macrophages and virus expression in chronically infected promonocytic U1 cells.
The binding subunit of pertussis toxin inhibits IL-1 induction of IL-2 and prostaglandin production.
The biochemical effect of the naturally occurring Trp64-->Arg mutation on human beta3-adrenoceptor activity.
The biological activity of the corticotropin-releasing hormone receptor-adenylate cyclase complex in human myometrium is reduced at the end of pregnancy.
The bombesin receptor is coupled to a guanine nucleotide-binding protein which is insensitive to pertussis and cholera toxins.
The bradykinin B2 receptor couples less efficiently than the angiotensin AT1 receptor to the G protein Gq in transiently transfected COS-7 cells.
The bradykinin receptor--a putative receptor-operated channel in PC12 cells: studies of neurotransmitter release and inositol phosphate accumulation.
The brain specific Ras exchange factor CDC25 Mm: modulation of its activity through Gi-protein-mediated signals.
The Burden of Pertussis in Patients with and without Recurrent Ischaemic Vascular Events.
The Bvg accessory factor (Baf) enhances pertussis toxin expression in Escherichia coli and is essential for Bordetella pertussis viability.
The bvgA gene of Bordetella pertussis encodes a transcriptional activator required for coordinate regulation of several virulence genes.
The C terminus of the human C5a receptor (CD88) is required for normal ligand-dependent receptor internalization.
The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells.
The C-terminal domain of the Gs-coupled EP4 receptor confers agonist-dependent coupling control to Gi but no coupling to Gs in a receptor hybrid with the Gi-coupled EP3 receptor.
The C-Type Natriuretic Peptide Induces Thermal Hyperalgesia through a Noncanonical G??-dependent Modulation of TRPV1 Channel.
The Ca(2+)-dependent activation by fluoride of human red cell membrane sodium permeability: evidence for a chemically activated tetrodotoxin-sensitive Na+ channel.
The Ca2+ influx induced by beta-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation.
The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway.
The Ca2+-sensing receptor couples to Galpha12/13 to activate phospholipase D in Madin-Darby canine kidney cells.
The calcitonin receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation. Involvement of Gi, protein kinase C, and calcium.
The calcium-sensing receptor regulates calcium absorption in MDCK cells by inhibition of PMCA.
The calcium-sensing receptor stimulates JNK in MDCK cells.
The cAMP assay: a functional in vitro alternative to the in vivo Histamine Sensitization test.
The canine mast cell activation via CRP.
The cannabinoid agonist DALN positively modulates L-type voltage-dependent calcium-channels in N18TG2 neuroblastoma cells.
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.
The cannabinoid receptor: biochemical and cellular properties in neuroblastoma cells.
The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin.
The carboxyl terminus of the S1 subunit of pertussis toxin confers high affinity binding to transducin.
The CART receptors: background and recent advances.
The CB(1) cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase.
The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan.
The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt.
The CB1 endocannabinoid system modulates adipocyte insulin sensitivity.
The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha.
The cell mediated and humoral immune response to vaccination with acellular and whole cell pertussis vaccine in adult humans.
The cellular and molecular basis of bitter tastant-induced bronchodilation.
The central analgesia induced by antimigraine drugs is independent from Gi proteins: superiority of a fixed combination of indomethacin, prochlorperazine and caffeine, compared to sumatriptan, in an in vivo model.
The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells.
The CGRP receptor can couple via pertussis toxin sensitive and insensitive G proteins.
The chemokine CCL2 increases Nav1.8 sodium channel activity in primary sensory neurons through a G??-dependent mechanism.
The chemokine CX3CL1 reduces migration and increases adhesion of neurons with mechanisms dependent on the beta1 integrin subunit.
The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis.
The chemokine CXCL14 (BRAK) stimulates activated NK cell migration: implications for the downregulation of CXCL14 in malignancy.
The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium.
The chemokine RANTES is more than a chemoattractant: characterization of its effect on human eosinophil oxidative metabolism and morphology in comparison with IL-5 and GM-CSF.
The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium.
The chemokine receptor CXCR4 enhances integrin-mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow.
The chemokine receptor CXCR4 is expressed within the mast cell lineage and its ligand stromal cell-derived factor-1alpha acts as a mast cell chemotaxin.
The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases.
The chemokine receptor CXCR6 and its ligand CXCL16 are expressed in carcinomas and inhibit proliferation.
The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood.
The chemokine stromal cell-derived factor-1 alpha modulates alpha 4 beta 7 integrin-mediated lymphocyte adhesion to mucosal addressin cell adhesion molecule-1 and fibronectin.
The chemokines CXCL9, CXCL10, and CXCL11 differentially stimulate G alpha i-independent signaling and actin responses in human intestinal myofibroblasts.
The chemotactic cytokine eotaxin acts as a granulocyte-macrophage colony-stimulating factor during lung inflammation.
The chromogranin A peptide vasostatin-I inhibits gap formation and signal transduction mediated by inflammatory agents in cultured bovine pulmonary and coronary arterial endothelial cells.
The chromogranin A-derived peptides vasostatin-I and catestatin as regulatory peptides for cardiovascular functions.
The chromosomal nature of LT-II enterotoxins solved: a lambdoid prophage encodes both LT-II and one of two novel pertussis-toxin-like toxin family members in type II enterotoxigenic Escherichia coli.
The class III antiarrhythmic drug amiodarone directly activates pertussis toxin-sensitive G proteins.
The cloned human 5-HT1E receptor couples to inhibition and activation of adenylyl cyclase via two distinct pathways in transfected BS-C-1 cells.
The cloned kappa opioid receptor couples to an N-type calcium current in undifferentiated PC-12 cells.
The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.
The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice.
The combined 5-HT2 receptor and calcium channel inhibitor LU49938 restores endothelium dependent responses in the regenerated endothelium of the porcine coronary artery.
The comparative analysis of proenkephalin mRNA expression induced by cholera toxin and pertussis toxin in primary cultured rat cortical astrocytes.
The complement component C5a induces the expression of plasminogen activator inhibitor-1 in human macrophages via NF-kappaB activation.
The complex interaction of ATP and UTP with isolated hepatocytes. How many receptors?
The concept of pertussis as a toxin-mediated disease.
The construction of a cloning vector designed for gene replacement in Bordetella pertussis.
The contractile action of platelet-activating factor on gallbladder smooth muscle.
The contribution of Gi/o protein to opioid antinociception in an oxaliplatin-induced neuropathy rat model.
The coupling of 5-oxo-eicosanoid receptors to heterotrimeric G proteins.
The critical points in induction of experimental autoimmune uveitis.
The crystal structure of pertussis toxin.
The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity.
The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes.
The CXCR4 agonist ligand stromal derived factor-1 maintains high affinity for receptors in both Galpha(i)-coupled and uncoupled states.
The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling.
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.
The D(3) dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK1, and Cdk-5.
The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus.
The D2 dopamine receptor isoforms signal through distinct Gi alpha proteins to inhibit adenylyl cyclase. A study with site-directed mutant Gi alpha proteins.
The D2 dopamine receptor mediates inhibition of growth in GH4ZR7 cells: involvement of protein kinase-C epsilon.
The D2 receptor: blocked transcription in GH3 cells and cellular pathways employed by D2A to regulate prolactin promoter activity.
The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein.
The D2S and D2L dopamine receptor isoforms are differentially regulated in Chinese hamster ovary cells.
The D2s dopamine receptor stimulates phospholipase D activity: a novel signaling pathway for dopamine.
The Decline of Pertussis-Specific Antibodies After Tetanus, Diphtheria, and Acellular Pertussis Immunization in Late Pregnancy.
The delta2-opioid receptor subtype stimulates phosphoinositide metabolism in mouse periaqueductal gray matter.
The development of hemopoietic cells in response to stromal cells or growth factors is modified by agents that influence ADP-ribosylation.
The development of physiologic responsiveness to muscarinic stimulation in embryonic chick heart. Relationship to increased levels of pertussis toxin substrates.
The differential effects of a selective kappa-opioid receptor agonist, U50488, in guinea pig heart tissues.
The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle.
The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins.
The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons.
The effect of 24R,25-(OH)(2)D(3) on protein kinase C activity in chondrocytes is mediated by phospholipase D whereas the effect of 1alpha,25-(OH)(2)D(3) is mediated by phospholipase C.
The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: signaling pathway.
The effect of amphiphilic polymers on growth of Bordetella pertussis and production of B. pertussis haemagglutinins.
The effect of C-terminal truncation of the recombinant delta-opioid receptor on Ca2+i signaling.
The effect of cholecystokinin on intracellular Ca2+, membrane-associated protein kinase-C activity, and progesterone production in chicken granulosa cells.
The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding.
The effect of CNTF on glutamate-induced increases in intracellular free Ca2+ in hippocampal neurons.
The effect of cyclic AMP elevating agents on bradykinin- and carbachol-induced signal transduction in canine cultured tracheal smooth muscle cells.
The effect of cyclodextrin on lipopolysaccharide production in cultures of Bordetella pertussis.
The effect of formaldehyde, hydrogen peroxide and genetic detoxification of pertussis toxin on epitope recognition by murine monoclonal antibodies.
The effect of Gi-protein inactivation on basal, and beta(1)- and beta(2)AR-stimulated contraction of myocytes from transgenic mice overexpressing the beta(2)-adrenoceptor.
The effect of glycosyl inositol-phosphate on cAMP production in isolated rat fat-cells is transduced by a pertussis toxin sensitive G-protein.
The effect of investigator compliance (observer bias) on calculated efficacy in a pertussis vaccine trial.
The effect of islet-activating protein (IAP) of pertussis toxin on the spontaneous diabetic syndrome in the rat.
The effect of maternal antibody on the serologic response and the incidence of adverse reactions after primary immunization with acellular and whole-cell pertussis vaccines combined with diphtheria and tetanus toxoids.
The Effect of Maternal Pertussis Immunization on Infant Vaccine Responses to a Booster Pertussis-Containing Vaccine in Vietnam.
The effect of nociceptin on Ca2+ channel current and intracellular Ca2+ in the SH-SY5Y human neuroblastoma cell line.
The effect of oxiferriscorbone on striatal adenylate cyclase of the rat.
The effect of pertussis toxin and whole-cell pertussis vaccine on haemodynamics and autonomic responsiveness in the rat depends on route of administration and age.
The effect of pertussis toxin on alpha 1-adrenoceptor-mediated vasoconstriction by the full agonist, cirazoline, and the partial agonist, (-)-dobutamine, in pithed rats.
The effect of pertussis toxin on alpha-2-adrenoceptor-mediated pigment migration in fish melanophores.
The effect of pertussis toxin on beta-adrenoceptor responses in isolated cardiac myocytes from noradrenaline-treated guinea-pigs and patients with cardiac failure.
The effect of pertussis toxin on mediator release from human basophils.
The effect of pertussis toxin on the growth of vascular smooth muscle cells stimulated by serum or platelet-derived growth factor.
The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in hedgehog signaling.
The effect of pertussis toxin treatment on alpha-1-adrenoceptor-mediated pressor responses in the pithed rat: dependence on agonist efficacy but not chemical class.
The effect of PGF2 alpha on parathyroid hormone-stimulated cyclic AMP production in mouse osteoblastic cell, MC3T3E1.
The effect of pH on the production of pertussis toxin by Bordetella pertussis.
The effect of site-directed mutagenesis of two transmembrane serine residues on agonist-specific coupling of a cloned human alpha2A-adrenoceptor to adenylyl cyclase.
The Effect of Tetanus-Diphtheria-Acellular-Pertussis Immunization During Pregnancy on Infant Antibody Responses: Individual-Participant Data Meta-Analysis.
The effect of timing of maternal tetanus, diphtheria, and acellular pertussis (Tdap) immunization during pregnancy on newborn pertussis antibody levels - a prospective study.
The effect of vasoactive intestinal polypeptide (VIP) on forskolin stimulated adenylate cyclase in the caudate-putamen of the rat.
The effect of vasoactive intestinal polypeptide on gastric acid secretion is predominantly mediated by somatostatin.
The effects of ageing on prejunctional 5-hydroxytryptamine receptors in the rat vas deferens.
The effects of amylin on insulin secretion from Rin m5F cells and glycogen synthesis and lipogenesis in rat primary cultured hepatocytes.
The effects of baclofen and pertussis toxin on epileptiform activity induced in the hippocampal slice by magnesium depletion.
The effects of cholera toxin, pertussis toxin, sodium fluoride and alpha-interferon on prostaglandin production by the guinea-pig endometrium.
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
The effects of endothelin on vascular tonus.
The effects of endothelin-1 on the PKA-dependent Cl- current in the heart.
The effects of endothelins on the secretion of prolactin, luteinizing hormone, and follicle-stimulating hormone are mediated by different guanine nucleotide-binding proteins.
The effects of extracellular calcium and epinephrine on cytosolic-free calcium in single rat adipocytes.
The effects of female sexual hormones on the expression and function of ?1A- and ?1D-adrenoceptor subtypes in the late-pregnant rat myometrium.
The effects of GH-releasing hormone/somatostatin on the 5'-promoter activity of the GH gene in vitro.
The effects of hydrostatic pressure on pertussis toxin-catalyzed ribosylation of G proteins from deep-living macrourid fishes.
The effects of in vitro and in vivo exposure to insulin upon prostaglandin E1 stimulation of platelet adenylate cyclase activity in healthy subjects.
The effects of interfering with GTP-binding proteins on the activation mechanism of calcium release-activated calcium current.
The effects of manufacture processes on post-translational modifications of bioactive proteins in pertussis vaccine.
The effects of pertussis toxin and cholera toxin on mitogen-induced interleukin-2 production: evidence for G protein involvement in signal transduction.
The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum.
The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve.
The effects of pertussis toxin on human T lymphocytes.
The effects of pertussis toxin on the induction and transfer of experimental autoimmune uveoretinitis.
The effects of pertussis toxin on vasoconstrictor and vasodilator agents in the pithed rat may not be an indicator of G-protein receptor coupling.
The effects of pertussis toxin-treatment on integrated vasoactive response of vascular system in spontaneously hypertensive rats.
The effects of phorbol 12-myristate 13-acetate, cholera toxin, prostaglandin E2 and norepinephrine on inducible nitric oxide synthase activation induced by lipopolysaccharide in C6 cells.
The effects of phorbol myristate acetate and chemotactic peptide on transmembrane potentials and cytosolic free calcium in mature granulocytes evolve sequentially as the cells differentiate.
The effects of purified pertussis components and lipopolysaccharide on the results of the mouse weight gain test.
The effects of recombinant rat mu-opioid receptor activation in CHO cells on phospholipase C, [Ca2+]i and adenylyl cyclase.
The effects of sigma ligands and of neuropeptide Y on N-methyl-D-aspartate-induced neuronal activation of CA3 dorsal hippocampus neurones are differentially affected by pertussin toxin.
The efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in a respiratory mouse model.
The efficiency of R5 HIV-1 infection is determined by CD4 T-cell surface CCR5 density through G alpha i-protein signalling.
The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors.
The endocrine-disrupting compound, nonylphenol, inhibits neurotrophin-dependent neurite outgrowth.
The endogenous benzodiazepine receptor ligand ODN increases cytosolic calcium in cultured rat astrocytes.
The endogenous cannabinoid anandamide inhibits alpha7 nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes.
The endogenous cannabinoid anandamide inhibits cromakalim-activated k+ currents in follicle-enclosed Xenopus oocytes.
The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines.
The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism.
The endozepine ODN stimulates polyphosphoinositide metabolism in rat astrocytes.
The enhanced antigen-specific production of cytokines induced by pertussis toxin is due to clonal expansion of T cells and not to altered effector functions of long-term memory cells.
The enhancement of dopamine D1 receptor desensitization by adenosine A1 receptor activation.
The epidermal growth factor receptor is coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rat hepatocytes.
The epidermal growth factor receptor is coupled to a phospholipase A2-specific pertussis toxin-inhibitable guanine nucleotide-binding regulatory protein in cultured rat inner medullary collecting tubule cells.
The epithelial phenotype of human neuroblastoma cells express bradykinin, endothelin, and angiotensin II receptors that stimulate phosphoinositide hydrolysis.
The Epstein-Barr virus BILF1 gene encodes a G protein-coupled receptor that inhibits phosphorylation of RNA-dependent protein kinase.
The Essential Role of Gi?2 in Prostate Cancer Cell Migration.
The evolving nature of Bordetella pertussis in Ontario, Canada, 2009-2017: strains with shifting genotypes and pertactin deficiency.
The excitatory effect of cholecystokinin on rat neostriatal neurons: ionic and molecular mechanisms.
The experimental power of FR900359 to study Gq-regulated biological processes.
The expression and function of G-proteins in experimental intimal hyperplasia.
The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration.
The failure of whooping-cough and adult sera to neutralise pertussis toxin.
The formation of skeletal muscle myotubes requires functional membrane receptors activated by extracellular ATP.
The formyl peptide chemoattractant receptor is encoded by a 2 kilobase messenger RNA. Expression in Xenopus oocytes.
The formylpeptide chemoattractant receptor copurifies with a GTP-binding protein containing a distinct 40-kDa pertussis toxin substrate.
The function but not the expression of rat liver inhibitory guanine nucleotide binding protein is altered in streptozotocin-induced diabetes.
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle.
The G protein beta3 subunit splice variant Gbeta3-s causes enhanced chemotaxis of human neutrophils in response to interleukin-8.
The G protein G13 mediates inhibition of voltage-dependent calcium current by bradykinin.
The G protein-activating peptide, mastoparan, and the synthetic NH2-terminal ARF peptide, ARFp13, inhibit in vitro Golgi transport by irreversibly damaging membranes.
The G Protein-coupled Receptor CysLT1 Mediates Chemokine-like Effects and Prolongs Survival in Chronic Lymphocytic Leukemia.
The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium-derived relaxing factor.
The G-protein G(i) regulates mitosis but not DNA synthesis in growth factor-activated fibroblasts: a role for the nuclear translocation of G(i).
The G-protein G(o) in mammalian cardiac muscle: localization and coupling to A1 adenosine receptors.
The G-protein inhibitor, pertussis toxin, inhibits the secretion of brain-derived neurotrophic factor.
The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain.
The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration.
The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.
The gene encoding the 17-kDa antigen of Bartonella henselae is located within a cluster of genes homologous to the virB virulence operon.
The glucocorticoid hormone dexamethasone reverses the growth hormone-releasing properties of the cholinomimetic carbachol.
The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive.
The glycosylphosphatidylinositol-linked Fc gamma receptor III represents the dominant receptor structure for immune complex activation of neutrophils.
The GTP-binding protein G(ialpha) translocates to kinetochores and regulates the M-G(1) cell cycle transition of Swiss 3T3 cells.
The GTP-binding protein Gi alpha 2 is directly linked to and substrate of a serine kinase in Balb/c3T3 cells.
The GTP-binding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells.
The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No.
The GTP-binding regulatory proteins, Gs and G(i), are altered in erythrocyte membranes of patients with ischemic heart disease resulting from coronary atherosclerosis.
The guanine-nucleotide-binding protein subunit G alpha i2 is involved in calcium activation of phospholipase A2. Effects of the dominant negative G alpha i2 mutant, [G203T]G alpha i2, on activation of phospholipase A2 in Chinese hamster ovary cells.
The H-L subgroup of guinea-pig cardiac M2 receptors (M2 beta) regulates inositol phosphate formation.
The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes.
The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways.
The heterotrimeric G protein G alpha i2 mediates lysophosphatidic acid-stimulated induction of the c-fos gene in mouse fibroblasts.
The heterotrimeric G protein Go2 regulates catecholamine uptake by secretory vesicles.
The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis.
The heterotrimeric GTP-binding protein, GS, modulates the Cl- conductance of rat parotid acinar secretory granules.
The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells.
The homophilic binding site of the neural cell adhesion molecule NCAM is directly involved in promoting neurite outgrowth from cultured neural retinal cells.
The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C.
The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells.
The human and dog 5-HT1D receptors can both activate and inhibit adenylate cyclase in transfected cells.
The human antimicrobial peptide dermcidin activates normal human keratinocytes.
The human chemoattractant complement C5a receptor inhibits cyclic AMP accumulation through Gi and Gz proteins.
The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells.
The human delta opioid receptor activates G(i1)alpha more efficiently than G(o1)alpha.
The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors.
The human galanin receptor: ligand-binding and functional characteristics in the Bowes melanoma cell line.
The human genome encodes at least three non-allellic G proteins with alpha i-type subunits.
The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils.
The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.
The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways.
The Identification and Localization of the Guanine Nucleotide Binding Protein G0 in the Auditory System.
The imidazoline NNC77-0020 affects glucose-dependent insulin, glucagon and somatostatin secretion in mouse pancreatic islets.
The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells.
The immunomodulator vasoactive intestinal peptide (VIP) does not affect experimental autoimmune uveitis (EAU) in B10.RIII mice.
The immunomodulatory effects of measles-mumps-rubella (MMR) vaccination on persistence of heterologous vaccine responses.
The impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: Secondary analysis of a randomised controlled trial.
The impact of RGS and other G-protein regulatory proteins on G?i-mediated signaling in immunity.
The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling.
The importance of Bordetella pertussis strains which do not produce virulence factors in the epidemiology of pertussis.
The in vitro invasive behavior of human myelomonocytic cell lines is modulated by HuIFN-gamma and pertussis toxin.
The incidence of Bordetella pertussis infections estimated in the population from a combination of serological surveys.
The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.
The induction of breast milk pertussis specific antibodies following gestational tetanus-diphtheria-acellular pertussis vaccination.
The inflammasome pyrin contributes to pertussis toxin-induced IL-1? synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis.
The inflammatory effects of UDP-glucose in N9 microglia are not mediated by P2Y14 receptor activation.
The inflammatory mediator leukotriene D4 triggers a rapid reorganisation of the actin cytoskeleton in human intestinal epithelial cells.
The influence of detergents on the availability of pertussis toxin substrates.
The influence of hypotonicity on large-conductance calcium-activated potassium channels in human retinal pigment epithelial cells.
The influence of K(+)-induced membrane depolarization on insulin secretion in islets of lean and obese (ob/ob) mice.
The influences of g proteins, ca, and k channels on electrical field stimulation in cat esophageal smooth muscle.
The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells.
The inhibition of alpha 1-adrenoceptor-mediated contractions of rabbit pulmonary artery by Ca2+-withdrawal, pertussis toxin and N-ethylmaleimide is dependent on agonist intrinsic efficacy.
The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP: evidence for a strong reduction of Ca2+ entry in single nerve terminals.
The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.
The inhibition of motility that results from contact between two oligodendrocytes in vitro can be blocked by pertussis toxin.
The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin.
The inhibition of stimulus-secretion coupling in pancreatic islets by volatile anaesthetics does not involve pertussis toxin sensitive G-proteins.
The inhibitory G protein G(i) identified as pertussis toxin-catalyzed ADP-ribosylation.
The inhibitory GTP-binding protein (Gi) occurs in rat Leydig cells and is differentially modified by lutropin and 12-O-tetradecanoylphorbol 13-acetate.
The inhibitory guanine nucleotide regulatory protein modulates agonist-stimulated cAMP production in rat osteosarcoma cells.
The inhibitory guanine nucleotide-binding protein (Ni) purified from bovine brain is a high affinity GTPase.
The inhibitory guanine nucleotide-binding regulatory subunit of adenylate cyclase has an adenylate cyclase-independent modulatory effect on ACTH secretion from mouse pituitary tumor cells.
The injury-induced myokine insulin-like 6 is protective in experimental autoimmune myositis.
The inositol phosphate response to thrombin in rat right atria differs from the response to noradrenaline.
The ins and outs of pertussis toxin.
The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells.
The insulin-secreting cell line, RINm5F, expresses an alpha-2D adrenoceptor and nonadrenergic idazoxan-binding sites.
The interaction between pertussis toxin and 10 monoclonal antibodies.
The interaction of a kainate receptor from goldfish brain with a pertussis toxin-sensitive GTP-binding protein.
The interaction of adenosine analogues with cAMP-generating and cAMP-independent positive inotropic agents in rabbit left atrium.
The interaction of nucleotides with pertussis toxin. Direct evidence for a nucleotide binding site on the toxin regulating the rate of ADP-ribosylation of Ni, the inhibitory regulatory component of adenylyl cyclase.
The interactions between the activatory guanine nucleotide binding protein and the catalytic subunit of adenylate cyclase in rat liver plasma membranes.
The interleukin-8 receptor B and CXC chemokines can mediate transendothelial migration of human skin homing T cells.
The involvement of GABAB receptors and coupled G-proteins in spinal GABAergic presynaptic inhibition.
The involvement of inositol phosphoglycan mediators in the modulation of steroidogenesis by insulin and insulin-like growth factor-I.
The involvement of K+ channels and Gi/o protein in the antinociceptive action of the gallic acid ethyl ester.
The involvement of pertussis toxin-sensitive G proteins in the post receptor mechanism of central I1-imidazoline receptors.
The involvement of products of the phospholipase pathway in the acute release of tissue-type plasminogen activator from perfused rat hindlegs.
The involvement of VEGF receptors and MAPK in the cannabinoid potentiation of Ca2+ flux into N18TG2 neuroblastoma cells.
The isoflavone Equol mediates rapid vascular relaxation: Ca2+-independent activation of endothelial nitric-oxide synthase/Hsp90 involving ERK1/2 and Akt phosphorylation in human endothelial cells.
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein.
The kyotorphin (tyrosine-arginine) receptor and a selective reconstitution with purified Gi, measured with GTPase and phospholipase C assays.
The location of filamentous hemagglutinin and pertussis toxin antigens of Bordetella pertussis by immunoelectron microscopy.
The longevity of the immune response to filamentous hemagglutinin and pertussis toxin in patients with pertussis in a semiclosed community.
The luteinizing hormone-releasing hormone receptor in human prostate cancer cells: messenger ribonucleic acid expression, molecular size, and signal transduction pathway.
The lymphocytosis promoting action of pertussis toxin can be mimicked in vitro. Holotoxin but not the B subunit inhibits invasion of human T lymphoma cells through fibroblast monolayers.
The lymphocytosis-promoting agent pertussis toxin affects virus burden and lymphocyte distribution in the SIV-infected rhesus macaque.
The lymphoma transmembrane glycoprotein GP85 (CD44) is a novel guanine nucleotide-binding protein which regulates GP85 (CD44)-ankyrin interaction.
The m2 muscarinic acetylcholine receptors are coupled to multiple signaling pathways via pertussis toxin-sensitive guanine nucleotide regulatory proteins.
The M2 muscarinic G-protein-coupled receptor is voltage-sensitive.
The M2 muscarinic receptor antagonist methoctramine activates mast cells via pertussis toxin-sensitive G proteins.
The M3 receptor-mediated K(+) current (IKM3), a G(q) protein-coupled K(+) channel.
The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism.
The macrophage-derived lectin, MNCF, activates neutrophil migration through a pertussis toxin-sensitive pathway.
The macrophage-derived neutrophil chemotactic factor, MNCF: A lectin with TNF-alpha-like activities on neutrophils.
The Major Leukocyte Chemotactic and Activating Factors in the Mouse Gut Lumen Are Not N-Formylpeptide Receptor 1 Agonists.
The mechanism for the rapid desensitization in bradykinin-stimulated inositol monophosphate production in NG108-15 cells involves interaction of a single receptor with multiple signaling pathways.
The mechanism of action of alpha 2-adrenoceptors in human isolated subcutaneous resistance arteries.
The mechanism of calcium channel facilitation in bovine chromaffin cells.
The mechanism of CD47-dependent killing of T cells: heterotrimeric Gi-dependent inhibition of protein kinase A.
The mechanism of contraction by 2-chloroadenosine in cat detrusor muscle cells.
The mechanism of MAP kinase activation under acidic condition in feline esophageal smooth muscle cells.
The mechanism of positive inotropy induced by adenosine triphosphate in rat heart.
The mechanisms of alpha(2)-adrenoceptor agonist-induced contraction in longitudinal muscle of the porcine uterus.
The Mel1a melatonin receptor is coupled to parallel signal transduction pathways.
The melanophore aggregating response of isolated fish scales: a very rapid and sensitive diagnosis of whooping cough.
The membrane-bound spermatozoal adenylyl cyclase system does not share coupling characteristics with somatic cell adenylyl cyclases.
The metabolism of sphingo(glyco)lipids is correlated with the differentiation-dependent autophagic pathway in HT-29 cells.
The metabotropic glutamate receptor MGLU7, activates PLC, translocates MUNC-13-1 protein and potentiates glutamate release at cerebrocortical nerve terminals.
The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.
The mineralocorticoid aldosterone activates a proton conductance in cultured kidney cells.
The modulation of placental lactogen release by opioids: a role for extracellular calcium.
The modulation of rat hippocampal synaptic conductances by baclofen and gamma-aminobutyric acid.
The molecular engineering of pertussis toxoid.
The monocyte chemotactic protein-4 induces oxygen radical production, actin reorganization, and CD11b up-regulation via a pertussis toxin-sensitive G-protein in human eosinophils.
The monomeric G proteins AGS1 and Rhes selectively influence Galphai-dependent signaling to modulate N-type (CaV2.2) calcium channels.
The morphologic change of endothelial cells by ancrod-generated fibrin is triggered by alpha v beta 3 integrin binding and the subsequent activation of a G-protein coupled phospholipase C.
The mouse as a model of experimental autoimmune uveoretinitis (EAU).
The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
The mouse putative pheromone receptor was specifically activated by stimulation with male mouse urine.
The mu opioid agonist DAMGO stimulates cAMP production in SK-N-SH cells through a PLC-PKC-Ca++ pathway.
The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation.
The myocardial depressant effect of volatile anesthetics does not involve arachidonic acid metabolites or pertussis toxin-sensitive G proteins.
The NAD-glycohydrolase activity of the pertussis toxin S1 subunit. Involvement of the catalytic HIS-35 residue.
The nature and origin of spontaneous noise in G protein-gated ion channels.
The negative inotropic effect of neuropeptide Y on the ventricular cardiomyocyte.
The neuropeptide FMRFa both inhibits and enhances the Ca2+ current in dissociated Helix neurons via independent mechanisms.
The neuropeptide pituitary adenylate cyclase activating polypeptide modulates Ca2+ and pro-inflammatory functions in human monocytes through the G protein-coupled receptors VPAC-1 and formyl peptide receptor-like 1.
The neuropeptide pituitary adenylate cyclase activating protein stimulates human monocytes by transactivation of the Trk/NGF pathway.
The neuropeptide Y/peptide YY Y1 receptor is coupled to MAP kinase via PKC and Ras in CHO cells.
The neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) modulate several biochemical pathways in human leukemic myeloid cells.
The neurotoxic prion peptide fragment PrP(106-126) is a chemotactic agonist for the G protein-coupled receptor formyl peptide receptor-like 1.
THE NEUTRALIZATION OF B. PERTUSSIS TOXIN IN A TISSUE CULTURE.
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells.
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor.
The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils.
The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi.
The new positive inotrope sulmazole inhibits the function of guanine nucleotide regulatory proteins by affecting GTP turnover.
The new strategy for allele identification of the genes coding for pertussis toxin subunit S1 (ptx S1) and pertactin (prn) in Bordetella pertussis.
The non-genomic rapid acidification in peripheral T cells by progesterone depends on intracellular calcium increase and not on Na+/H+-exchange inhibition.
The nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine3A receptor-mediated currents in Xenopus laevis oocytes.
The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways.
The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases.
The opioid peptide dynorphin modulates AMPA and kainate responses in acutely isolated neurons from the dorsal horn.
The opposing effects of calmodulin, adenosine 5'-triphosphate, and pertussis toxin on phorbol ester induced inhibition of atrial natriuretic factor stimulated guanylate cyclase in SK-NEP-1 cells.
The optimal gestation for pertussis vaccination during pregnancy: a prospective cohort study.
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
The oxime HGG-12 as a muscarinic acetylcholine receptor antagonist without intrinsic activity in cardiac membranes.
The P2U purinoceptor obligatorily engages the heterotrimeric G protein G16 to mobilize intracellular Ca2+ in human erythroleukemia cells.
The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase.
The P2Y purinoceptor-operated potassium channel is possibly regulated by the beta gamma subunits of a pertussis toxin-insensitive G-protein in cultured rat inferior colliculus neurons.
The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues.
The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion.
The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration.
The palmitoylation status of the G-protein G(o)1 alpha regulates its activity of interaction with the plasma membrane.
The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes.
The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling.
The pertussis hypothesis: Bordetella pertussis colonization in the etiology of asthma and diseases of allergic sensitization.
The pertussis toxin liberation genes of Bordetella pertussis are transcriptionally linked to the pertussis toxin operon.
The pertussis toxin S1 subunit is a thermally unstable protein susceptible to degradation by the 20S proteasome.
The phorbol ester TPA potentiates cholera toxin- and isoproterenol-stimulated cyclic AMP-synthesis in primary astrocyte cultures.
The phospholipase C activating P2U purinoceptor also inhibits cyclicAMP formation in DDT1 MF-2 smooth muscle cells.
The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase.
The phosphotyrosine phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2.
The photoactivatable NAD+ analogue [32P]2-azido-NAD+ defines intra- and inter-molecular interactions of the C-terminal domain of the G-protein G alpha t.
The pituitary adenylate cyclase activating polypeptide (PACAP I) and VIP (PACAP II VIP1) receptors stimulate inositol phosphate synthesis in transfected CHO cells through interaction with different G proteins.
The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice.
The PLPp-specific T-cell population promoted by pertussis toxin is characterized by high frequencies of IL-17-producing cells.
The possible mechanisms by which phanoside stimulates insulin secretion from rat islets.
The potential of adjuvants to improve immune responses against TdaP vaccines: A preclinical evaluation of MF59 and monophosphoryl lipid A.
The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis.
The potentiating effects of phorbol ester on ACTH-, cholera toxin-, and forskolin-induced cAMP production by cultured bovine adrenal cells is not mediated by the inactivation of alpha subunit of Gi protein.
The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling.
The presence of a heterotrimeric G protein and its role in signal transduction of extracellular calmodulin in pollen germination and tube growth
The presence of atrial-natriuretic-factor receptors of ANF-R2 subtype in rat platelets. Coupling to adenylate cyclase/cyclic AMP signal-transduction system.
The presumed atypical chemokine receptor CXCR7 signals through G(i/o) proteins in primary rodent astrocytes and human glioma cells.
The prevention of severe pertussis and pertussis deaths in young infants.
The primary and secondary cellular immune responses to whole cell Bordetella pertussis vaccine and its components.
The primary structure of the alpha subunit of a starfish guanosine-nucleotide-binding regulatory protein involved in 1-methyladenine-induced oocyte maturation.
The priming effect of 12(S)-hydroxyeicosatetraenoic acid on lymphocyte phospholipase D involves specific binding sites.
The product of a novel growth factor-activated gene, fic, is a biologically active "C-C"-type cytokine.
The proliferative effect of vascular endothelial growth factor requires protein kinase C-alpha and protein kinase C-zeta.
The proline residue at position 319 of BvgS is essential for BvgAS activation in Bordetella pertussis.
The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins.
The prostaglandin E series modulates high-voltage-activated calcium channels probably through the EP3 receptor in rat paratracheal ganglia.
The protective effect of atrial natriuretic peptide (ANP) on cells damaged by oxygen radicals is mediated through elevated CGMP-levels, reduction of calcium-inflow and probably G-proteins.
The protective effect of immunisation against diphtheria, pertussis and tetanus (DPT) in relation to sudden infant death syndrome.
The protein kinase C activator 1-oleoyl-2-acetylglycerol inhibits voltage-dependent Ca2+ current in the pituitary cell line AtT-20.
The proteinase-activated receptor-2 mediates phagocytosis in a Rho-dependent manner in human keratinocytes.
The proximal portion of the COOH terminus of the oxytocin receptor is required for coupling to g(q), but not g(i). Independent mechanisms for elevating intracellular calcium concentrations from intracellular stores.
The PtlE protein of Bordetella pertussis has peptidoglycanase activity required for Ptl-mediated pertussis toxin secretion.
The purification and characterization of an acellular pertussis vaccine.
The purification and protective capacity of Bordetella pertussis outer membrane proteins.
The purification of a cysteine-dependent NAD+ glycohydrolase activity from bovine erythrocytes and evidence that it exhibits a novel ADP-ribosyltransferase activity.
The purification of a guanine nucleotide regulatory protein from rat brain membrane and the measurement of its GTPase.
The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death.
The putative <> 5-HT(1A) receptor antagonist, WAY 100635, has inverse agonist properties at cloned human 5-HT(1A) receptors.
The putative melatonin receptor antagonist GR128107 is a partial agonist on Xenopus laevis melanophores.
The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines.
The rabbit neutrophil N-formyl peptide receptor. cDNA cloning, expression, and structure/function implications.
The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion.
The Rate of CD4 T Cell Entry into the Lungs during Mycobacterium tuberculosis Infection Is Determined by Partial and Opposing Effects of Multiple Chemokine Receptors.
The reaction of bacterial toxins with formaldehyde and its use for antigen stabilization.
The receptor attributable to C-type natriuretic peptide-induced differentiation of osteoblasts is switched from type B- to type C-natriuretic peptide receptor with aging.
The receptor mechanism mediating the contractile response to adenosine on lung parenchymal strips from actively sensitised, allergen-challenged Brown Norway rats.
The receptors for ATP and fMetLeuPhe are independently coupled to phospholipases C and A2 via G-protein(s). Relationship between phospholipase C and A2 activation and exocytosis in HL60 cells and human neutrophils.
The reduction of neuronal calcium currents by ATP-gamma-S is mediated by a G protein and occurs independently of cyclic AMP-dependent protein kinase.
The reemergence of pertussis in immunized populations: a case study.
The regulation of adenylate cyclase by guanine nucleotides in Dictyostelium discoideum membranes.
The regulation of adenylate cyclase in liver membranes of lean and obese mice.
The regulation of neutrophil phospholipase A2 by granulocyte-macrophage colony-stimulating factor and its role in priming superoxide production.
The regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha.
The regulator of G-protein signaling RGS16 promotes insulin secretion and ?-cell proliferation in rodent and human islets.
The regulatory effect of liuwei dihuang pills on cytokines in mice with experimental autoimmune encephalomyelitis.
The relationship between 3',5'-cyclic adenosine monophosphate and calcium in mediating follicle-stimulating hormone signal transduction in Sertoli cells.
The relationship between Bordetella pertussis genotype and clinical severity in Australian children with pertussis.
The relationship between motility factor receptor internalization and the lung colonization capacity of murine melanoma cells.
The relationship between pertussis-toxin-induced ADP-ribosylation of a plasma-membrane protein and reversal of muscarinic inhibition of prolactin secretion in GH3 cells.
The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens {alpha}-toxin.
The release of endothelium-derived relaxing factor via alpha 2-adrenergic receptor activation is specifically mediated by Gi alpha 2.
The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment.
The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin.
The Rho/Rho-kinase and the phosphatidylinositol 3-kinase pathways are essential for spontaneous locomotion of Walker 256 carcinosarcoma cells.
The rise in pertussis cases urges replacement of chemically-inactivated with genetically-inactivated toxoid for DTP.
The RNA Chaperone Hfq is Required for Virulence of Bordetella pertussis.
The role of A3 adenosine receptors in central regulation of arterial blood pressure.
The role of autotaxin and other motility stimulating factors in the regulation of tumor cell motility.
The role of beta-adrenergic receptor signaling in cardioprotection.
The role of beta-arrestins in the formyl peptide receptor-like 1 internalization and signaling.
The role of calcium in modulating the reactivity of the smooth muscle cells during ischemia/reperfusion. Part 1.
The role of cyclic nucleotides in atrial natriuretic peptide-mediated inhibition of aldosterone secretion.
The role of cysteine 41 in the enzymatic activities of the pertussis toxin S1 subunit as investigated by site-directed mutagenesis.
The role of cytosolic free calcium in the generation of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in HL-60 cells. Differential effects of chemotactic peptide receptor stimulation at distinct Ca2+ levels.
The role of G protein in muscarinic depolarization near resting potential in cultured hippocampal neurons.
The role of G protein methylation in the function of a geranylgeranylated beta gamma isoform.
The role of G proteins in the activity and mercury modulation of GABA-induced currents in rat neurons.
The role of G proteins in thromospondin-1-induced vascular smooth muscle cell migration.
The role of G-protein in matrix-mediated motility of highly and poorly invasive melanoma cells.
The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization.
The role of G-proteins in the activation of human leukocytes by particulate stimuli to produce reactive oxygen metabolites.
The role of G-proteins in the dimerisation of human somatostatin receptor types 2 and 5.
The role of G-proteins in the mitogenesis of rat lactogen-dependent and lactogen-independent Nb2 lymphoma cells.
The role of Gi and the membrane-fluidizing agent benzyl alcohol in modulating the hysteretic activation of human platelet adenylate cyclase by guanylyl 5'-imidodiphosphate.
The role of Gi proteins in reduced vasorelaxation response to beta-adrenoceptor agonists in rat aorta during maturation.
The role of Gi-proteins and beta-adrenoceptors in the age-related decline of contraction in guinea-pig ventricular myocytes.
The role of glial cells in influencing neurite extension by dorsal root ganglion cells.
The role of GTP binding proteins in ischemic brain damage: autoradiographic and histopathological study.
The role of guanyl nucleotide binding proteins in the formation of inositol phosphates in adrenal glomerulosa cells.
The role of intracellular acidification in calcium mobilization in human neutrophils.
The role of lysophosphatidic acid receptors in phenotypic modulation of vascular smooth muscle cells.
The Role of M. leprae Hsp65 Protein and Peptides in the Pathogenesis of Uveitis.
The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel.
The role of mitogen-activated protein kinases in eotaxin-induced cytokine production from bronchial epithelial cells.
The role of N-, Q- and R-type Ca2+ channels in feedback inhibition of ACh release from rat basal forebrain neurones.
The role of neutrophils in tissue localized cell-mediated immunologic responses: I. The intensity of contact-type and delayed-type hypersensitivity responses may be influenced by the extent of extracellular matrix degradation by neutrophil proteases.
The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
The role of pertussis toxin and betamethasone on lymphocyte accumulation in the lungs of mice.
The role of potassium channels in antihistamine analgesia.
The role of protein kinase C in alpha-adrenergic regulation of NaCl(K) cotransport in human airway epithelial cells.
The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation.
The role of spinally located dopamine D2 receptors in the regulation of the blood glucose level in mice.
The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse.
The role of the cytosolic free Ca2+ transient for fMet-Leu-Phe induced actin polymerization in human neutrophils.
The role of the GPR91 ligand succinate in hematopoiesis.
The role of the nucleus accumbens in sensitization to drugs of abuse.
The role of the S-1 and B-oligomer components of pertussis toxin in its adjuvant properties for Th1 and Th2 cells.
The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system.
The role of Toll-like receptor-4 in pertussis vaccine-induced immunity.
The roles of alpha2-adrenoceptor subtypes in the control of cervical resistance in the late-pregnant rat.
The seroepidemiology of B. pertussis infection in Catalonia, Spain.
The seroepidemiology of Bordetella pertussis in Israel--Estimate of incidence of infection.
The seroepidemiology of Bordetella pertussis infection in Western Europe.
The seroepidemiology of Bordetella pertussis infections: a study of persons ages 1-65 years.
The seroepidemiology of Immunoglobulin G antibodies against pertussis toxin in China: a cross sectional study.
The seroepidemiology of pertussis in Australia during an epidemic period.
The seroepidemiology of pertussis in NSW: fluctuating immunity profiles related to changes in vaccination schedules.
The short-chain free fatty acid receptor FFAR3 is expressed and potentiates contraction in human airway smooth muscle.
The signal transduction of endothelin-1-induced circular smooth muscle cell contraction in cat esophagus.
The signal transduction pathway causing the synergistic hypertrophic effects of neuropeptide Y and norepinephrine on primary cardiomyocyte.
The signal transduction pathway involved in the migration induced by a monocyte chemotactic cytokine.
The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells.
The signaling pathway in photoresponses that may be mediated by visual pigments in erythrophores of Nile tilapia.
The signaling pathways linking to lysophosphatidic acid-promoted meiotic maturation in mice.
The signaling signature of the neurotensin type 1 receptor with endogenous ligands.
The somatostatin receptor family.
The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells.
The somatostatin receptors SSTR1 and SSTR2 are coupled to inhibition of adenylyl cyclase in Chinese hamster ovary cells via pertussis toxin-sensitive pathways.
The specific activation of TRPC4 by Gi protein subtype.
The specific GTP requirement for inositol 1,4,5-trisphosphate-induced Ca2+ release from skinned vascular smooth muscle.
The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator.
The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen.
The spleen is a major site of megakaryopoiesis following transplantation of murine hematopoietic stem cells.
The standardization of an assay for pertussis toxin and antitoxin in microplate culture of Chinese hamster ovary cells.
The steroidal Na+/K+ ATPase inhibitor 3-[(R)-3-pyrrolidinyl]oxime derivative (3-R-POD) induces potent pro-apoptotic responses in colonic tumor cells.
The stimulation of beta(3)-adrenoceptor causes phosphorylation of extracellular signal-regulated kinases 1 and 2 through a G(s)- but not G(i)-dependent pathway in 3T3-L1 adipocytes.
The stimulation of human neutrophil migration by angiotensin IL: its dependence on Ca2+ and the involvement of cyclic GMP.
The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme.
The stimulation of lymphocyte motility by cultured high endothelial cells and its inhibition by pertussis toxin.
The stimulatory and inhibitory effects of dopamine on prolactin secretion involve different G-proteins.
The stimulatory and inhibitory effects of quinpirole hydrochloride, D2-dopamine receptor agonist, on secretion of prolactin as assessed by the reverse hemolytic plaque assay.
The stimulatory and inhibitory guanine nucleotide-binding proteins of adenylate cyclase in erythrocytes from patients with pseudohypoparathyroidism type I.
The stimulatory effect of cannabinoids on calcium uptake is mediated by Gs GTP-binding proteins and cAMP formation.
The stimulatory effect of insulin on diacylglycerol generation in adipocyte membranes from ob/ob mice is impaired by growth hormone.
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.
The stimuli releasing histamine from murine bone marrow-derived mast cells. 2. Mechanisms involved in histamine release induced by extracellular ATP and its metabolites.
The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques.
The subcellular localization of the G-protein Gi alpha in the basal ganglia reveals its potential role in both signal transduction and vesicle trafficking.
The subunit S1 is important for pertussis toxin secretion.
The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner.
The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met is a potent chemotactic agonist for mouse formyl peptide receptor.
The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells.
The tachykinin NK1 receptor. Part I: ligands and mechanisms of cellular activation.
The terminal complement complex C5b-9 stimulates interleukin-6 production in human smooth muscle cells through activation of transcription factors NF-kappa B and AP-1.
The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor.
The third signal in T cell-mediated autoimmune disease?
The thrombin receptor in adrenal medullary microvascular endothelial cells is negatively coupled to adenylyl cyclase through a Gi protein.
The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways.
The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi.
The thromboxane A2 receptor activates mitogen-activated protein kinase via protein kinase C-dependent Gi coupling and Src-dependent phosphorylation of the epidermal growth factor receptor.
The thyrotropin receptor is not involved in the activation of p42/p44 mitogen-activated protein kinases by thyrotropin preparations in Chinese hamster ovary cells expressing the human thyrotropin receptor.
The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies.
The transduction signalling protein Go during embryonic development of Drosophila melanogaster.
The type I insulin-like growth factor receptor is a motility receptor in human melanoma cells.
The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling.
The use of Haemophilus influenzae type b-tetanus toxoid conjugate vaccine mixed with diphtheria-tetanus-pertussis vaccine in Gambian infants.
The use of microcalorimetry to characterize tetanus neurotoxin, pertussis toxin and filamentous haemagglutinin.
The use of the potential-sensitive fluorescent probe bisoxonol in mast cells.
The uterotonic action of the aqueous extract of Bridelia atroviridis in the rat.
The utility of seroepidemiology for tracking trends in pertussis infection.
The vaccine containing recombinant pertussis toxin induces early and long-lasting protection.
The Virulence Factors of Bordetella pertussis: Talented Modulators of Host Immune Response.
Theileria parva sporozoite entry into bovine lymphocytes involves both parasite and host cell signal transduction processes.
Therapeutic approach by Aloe vera in experimental model of multiple sclerosis.
Therapeutic effect of EDTA in experimental model of multiple sclerosis.
Thermal injury induces macrophage hyperactivity through pertussis toxin-sensitive and -insensitive pathways.
Thermal Unfolding of the Pertussis Toxin S1 Subunit Facilitates Toxin Translocation to the Cytosol by the Mechanism of Endoplasmic Reticulum-Associated Degradation.
Thimerosal-induced Ca2+ mobilization in isolated guinea pig cochlear outer hair cells.
Thioaryl naphthylmethanone oxime ether analogs as novel anticancer agents.
Thiol reagents are substrates for the ADP-ribosyltransferase activity of pertussis toxin.
Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells.
Third prize: Prostaglandin E(2)-3 receptor is involved in ureteral contractility in obstruction.
Third-Trimester Maternal Vaccination Against Pertussis and Pertussis Antibody Concentrations.
Three distinct G protein pathways mediate inhibition of neuronal calcium current by bradykinin.
Three states for the formyl peptide receptor on intact cells.
Threshold and graded response behavior in human neutrophils: effect of varying G-protein or ligand concentrations.
Threshold-dependent DNA synthesis by pure pressure in human aortic smooth muscle cells: Gialpha-dependent and -independent pathways.
Thrombin activates mitogen-activated protein kinase in primary astrocyte cultures.
Thrombin activation of the Na+/H+ exchanger in vascular smooth muscle cells. Evidence for a kinase C-independent pathway which is Ca2+-dependent and pertussis toxin-sensitive.
Thrombin and phorbol esters cause the selective phosphorylation of a G protein other than Gi in human platelets.
Thrombin and trypsin induce granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes.
Thrombin Ca(2+)-dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells.
Thrombin induces c-fos expression in cultured human endothelial cells by a Ca2(+)-dependent mechanism.
Thrombin induces mast cell adhesion to fibronectin: evidence for involvement of protease-activated receptor-1.
Thrombin induces neoangiogenesis in the chick chorioallantoic membrane.
Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis.
Thrombin induces proteinase-activated receptor-1 gene expression in endothelial cells via activation of Gi-linked Ras/mitogen-activated protein kinase pathway.
Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1.
Thrombin is a novel regulator of hexokinase activity in mesangial cells.
Thrombin modulates phosphoinositide metabolism, cytosolic calcium, and impulse initiation in the heart.
Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells.
Thrombin receptor activating peptide (TRAP) stimulates mitogenesis, c-fos and PDGF-A gene expression in human vascular smooth muscle cells.
Thrombin receptor activation by thrombin and receptor-derived peptides in platelet and CHRF-288 cell membranes: receptor-stimulated GTPase and evaluation of agonists and partial agonists.
Thrombin receptor agonist peptide induction of mitogenesis in CCL39 cells.
Thrombin receptor on rat primary hippocampal neurons: coupled calcium and cAMP responses.
Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes.
Thrombin signal transduction of the fibrinolytic system in human adult venous endothelium in vitro.
Thrombin signalling in U937 human monocytic cells is coupled to inositol phosphate formation but not to thromboxane B2 synthesis nor to inhibition of adenylate cyclase: distinct differences in thrombin signalling between U937 cells and platelets.
Thrombin stimulates inositol phosphate formation, intracellular calcium fluxes and DNA synthesis in cultured fetal human non-pigmented ciliary epithelial cells.
Thrombin stimulates inositol phosphate production and intracellular free calcium by a pertussis toxin-insensitive mechanism in osteosarcoma cells.
Thrombin stimulates pertussis toxin-sensitive and -insensitive GTPase activities and ADP-ribosylation of G(i) in human neuroblastoma SH-EP.
Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets.
Thrombin-induced activation of cultured rodent microglia.
Thrombin-induced Ca2+ mobilization in vascular smooth muscle utilizes a slowly ribosylating pertussis toxin-sensitive G protein. Evidence for the involvement of a G protein in inositol trisphosphate-dependent Ca2+ release.
Thrombin-induced proliferation and expression of platelet-derived growth factor-A chain gene in human vascular smooth muscle cells.
Thrombin-induced prostacyclin biosynthesis in human endothelium: role of guanine nucleotide regulatory proteins in stimulus/coupling responses.
Thrombin-mediated phosphoinositide hydrolysis in Chinese hamster ovary cells overexpressing phospholipase C-delta 1.
Thrombin-promoted release of UDP-glucose from human astrocytoma cells.
Thrombin-stimulated cell proliferation mediated through activation of Ras/Raf/MEK/MAPK pathway in canine cultured tracheal smooth muscle cells.
Thrombin-stimulated proliferation of cultured human synovial fibroblasts through proteolytic activation of proteinase-activated receptor-1.
Thrombospondin modulates alpha v beta 3 function through integrin-associated protein.
Thrombospondin promotes chemotaxis and haptotaxis of human peripheral blood monocytes.
Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation.
Thrombospondin-1 differentially induces chemotaxis and DNA synthesis of human venous smooth muscle cells at the receptor-binding level.
Thromboxane A(2) receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells.
Thromboxane A2 activates phospholipase C in astrocytoma cells via pertussis toxin-insensitive G-protein.
Thromboxane A2 agonist modulation of excitatory synaptic transmission in the rat hippocampal slice.
Thromboxane A2 analogue U 46619 enhances tumour cell proliferation in HeLa cells via specific receptors which are apparently distinct from TXA2 receptors on human platelets.
Thromboxane A2 and vascular smooth muscle cell proliferation.
Thromboxane A2 mediates the stimulation of inositol 1,4,5-trisphosphate production and intracellular calcium mobilization by bradykinin in neonatal rat ventricular cardiomyocytes.
Thromboxane A2 receptor activates a rock/LKB1/Pten pathway to attenuate endothelium insulin signaling.
Thromboxane A2 receptor-mediated signal transduction in rabbit aortic smooth muscle cells.
Thromboxane prostanoid receptor in human airway smooth muscle cells: a relevant role in proliferation.
Thromboxane prostanoid receptor signals through Gi protein to rapidly activate extracellular signal-regulated kinase in human airways.
Thromboxane receptor signalling in human myometrial cells.
Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3.
Thy-1 antibody-triggered neurite outgrowth requires an influx of calcium into neurons via N- and L-type calcium channels.
Thymic emigrants isolated by a new method possess unique phenotypic and functional properties.
Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.
Thymoquinone-induced Neu4 sialidase activates NF?B in macrophage cells and pro-inflammatory cytokines in vivo.
Thymoquinone-induced platelet apoptosis.
Thyroliberin action in pituitary cells is not inhibited by pertussis toxin.
Thyrotropin Causes Dose-dependent Biphasic Regulation of cAMP Production Mediated by Gs and Gi/o Proteins.
Thyrotropin effect on the availability of Ni regulatory protein in FRTL-5 rat thyroid cells to ADP-ribosylation by pertussis toxin.
Thyrotropin stimulates invasion and growth of follicular thyroid cancer cells via PKC- rather than PKA-activation.
Thyrotropin-releasing hormone activates a Ca2+-dependent polyphosphoinositide phosphodiesterase in permeable GH3 cells. GTP gamma S potentiation by a cholera and pertussis toxin-insensitive mechanism.
Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to the guanosine triphosphate-binding proteins Gq and G11.
Thyrotropin-releasing hormone and gonadotropin-releasing hormone-associated peptide modulation of [Ca2+]i in human lactotrophs.
Thyrotropin-releasing hormone induces opposite effects on Ca2+ channel currents in pituitary cells by two pathways.
Thyrotropin-releasing hormone stimulation of polyphosphoinositide hydrolysis in GH3 cell membranes is GTP dependent but insensitive to cholera or pertussis toxin.
Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity.
Time course of action of pertussis toxin to block the inhibition of stimulated insulin release by norepinephrine.
Time-course of infection and responses in a coughing rat model of pertussis.
Time-dependent effects of in vivo pertussis toxin on morphine analgesia and G-proteins in mice.
Time-dependent reversal of long-term potentiation by low-frequency stimulation at the hippocampal mossy fiber-CA3 synapses.
Time-dependent vascular actions of cannabidiol in the rat aorta.
TIMP-1 inhibits apoptosis in breast carcinoma cells via a pathway involving pertussis toxin-sensitive G protein and c-Src.
Tiopronin (2-mercaptopropionylglycine) has chemokinetic and chemotactic properties for polymorphonuclear leukocytes.
Tissue factor is induced by monocyte chemoattractant protein-1 in human aortic smooth muscle and THP-1 cells.
Tissue plasminogen activator increases canine endothelial cell proliferation rate through a plasmin-independent, receptor-mediated mechanism.
Tissue- and subunit-specific regulation of G-protein expression by hypo- and hyperthyroidism.
Titration of myelin oligodendrocyte glycoprotein (MOG) - Induced experimental autoimmune encephalomyelitis (EAE) model.
TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae.
TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease.
Tn5-induced mutations affecting virulence factors of Bordetella pertussis.
TNF alpha-induced activation of eosinophil oxidative metabolism and morphology--comparison with IL-5.
TNF-alpha rapidly antagonizes the beta-adrenergic responses of the chloride current in guinea-pig ventricular myocytes.
TNF-alpha stimulates increased plasma membrane guanine nucleotide binding protein activity in polymorphonuclear leukocytes.
TNF-alpha stimulates monocyte adhesion to glomerular mesangial cells. The role of intercellular adhesion molecule-1 gene expression and protein kinases.
TNF-[alpha] modulates murine tracheal rings responsiveness to G-protein-coupled receptor agonists and KCl.
TNF-{alpha} potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts.
Tofacitinib inhibits the development of experimental autoimmune uveitis and reduces the proportions of Th1 but not of Th17 cells.
Tolerance induction by acylated peptides: suppression of EAE in the mouse with palmitoylated PLP peptides.
Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NFkappaB activation.
Tonic inhibition and rebound facilitation of a neuronal calcium channel by a GTP-binding protein.
Tonic inhibition of adenylate cyclase in cultured hamster Sertoli cells.
Tonic inhibition of renal response to vasopressin by a pertussis toxin substrate.
Toosendanin induces outgrowth of neuronal processes and apoptosis in PC12 cells.
Topographic analysis of antigenic determinants recognized by monoclonal antibodies to the photoreceptor guanyl nucleotide-binding protein, transducin.
Topological mimicry and epitope duplication in the guanylyl cyclase C receptor.
Total body irradiation causes profound changes in endothelial traffic molecules for hematopoietic progenitor cell recruitment to bone marrow.
Toward a mechanism-based in vitro safety test for pertussis toxin.
Toward an Alum Free Mono-Component Monovalent Pertussis Vaccine: A Cytokine Response Assay.
Towards better pertussis vaccines.
Towards replacement of the acellular pertussis vaccine safety test: Comparison of in vitro cytotoxic activity and in vivo activity in mice.
Towards third-generation whooping cough vaccines.
Toxicity of the specific antimuscarinic agent methoctramine and other non-specific anticholinergic drugs in human neuroblastoma cell lines in vitro.
Toxin-neutralizing antibodies in patients with pertussis, as determined by an assay using Chinese hamster ovary cells.
Toxins which activate adenylate cyclase.
Toxins-useful biochemical tools for leukocyte research.
Toxoplasma gondii triggers Gi-dependent PI 3-kinase signaling required for inhibition of host cell apoptosis.
TPA induction of EL4 resistance to macrophage-released TNF: role of ADP-ribosylation in tumoricidal activities of TNF and other factors.
Trafficking of neutrophils across airway epithelium is dependent upon both thioredoxin- and pertussis toxin-sensitive signaling mechanisms.
Trans-ACPD inhibits cAMP formation via a pertussis toxin-sensitive G-protein.
Trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons.
Trans-cinnamic acid increases adiponectin and the phosphorylation of AMP-activated protein kinase through G-protein-coupled receptor signaling in 3T3-L1 adipocytes.
Transactivation of CXCR4 by the insulin-like growth factor-1 receptor (IGF-1R) in human MDA-MB-231 breast cancer epithelial cells.
Transcription mediated by a cAMP-responsive promoter element is reduced upon activation of dopamine D2 receptors.
Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins.
Transcriptional activation of gonadotropin-releasing hormone (GnRH) receptor gene by GnRH and cyclic adenosine monophosphate.
Transcriptional regulation of Na/K-ATPase by corticosteroids, glycyrrhetinic acid and second messenger pathways in rat kidney epithelial cells.
Transducin and the cyclic GMP phosphodiesterase: amplifier proteins in vision.
Transduction mechanism involving the presynaptic adenosine receptor at mouse motor nerve terminals.
Transduction mechanisms involved in thrombin receptor-induced nerve growth factor secretion and cell division in primary cultures of astrocytes.
Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors.
Transduction of the chemotactic signal to the actin cytoskeleton of Dictyostelium discoideum.
Transduction of the modulatory effect of catecholamines at the mammalian motor neuron terminal.
Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation.
Transfected adenosine A1 receptor-mediated modulation of thrombin-stimulated phospholipase C and phospholipase A2 activity in CHO cells.
Transfected D2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells.
Transfected D2 short dopamine receptors inhibit voltage-dependent potassium current in neuroblastoma x glioma hybrid (NG108-15) cells.
Transfected human somatostatin receptor type 2, SSTR2, not only inhibits adenylate cyclase but also stimulates phospholipase C and Ca2+ mobilization.
Transfected m2 muscarinic acetylcholine receptors couple to G alpha i2 and G alpha i3 in Chinese hamster ovary cells. Activation and desensitization of the phospholipase C signaling pathway.
Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells.
Transfection of NG108-15 cells with antisense opioid-binding cell adhesion molecule cDNA alters opioid receptor-G-protein interaction.
Transfer of a pertussis toxin expression locus to isogenic bvg-positive and bvg-negative strains of Bordetella bronchiseptica using an in vivo technique.
Transfer of thyroiditis, with syngeneic spleen cells sensitized with the human thyrotropin receptor, to naive BALB/c and NOD mice.
Transferability of dermal temperature histamine sensitisation test for estimation of pertussis toxin activity in vaccines.
Transferability study of CHO cell clustering assays for monitoring of pertussis toxin activity in acellular pertussis vaccines.
Transformation by a nucleotide-activated P2Y receptor is mediated by activation of Galphai, Galphaq and Rho-dependent signaling pathways.
Transforming growth factor ?2 (TGF-?2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells.
Transforming growth factor beta 1 treatment of AKR-2B cells is coupled through a pertussis-toxin-sensitive G-protein(s).
Transforming growth factor beta enhances parathyroid hormone stimulation of adenylate cyclase in clonal osteoblast-like cells.
Transforming growth factor-beta 1 has both promoting and inhibiting effects on induction of DNA synthesis in human fibroblasts.
Transforming growth factor-beta 1 regulation of signal transduction in two renal epithelial cell lines.
Transforming growth factor-beta up-regulates low density lipoprotein receptor-mediated cholesterol metabolism in vascular smooth muscle cells.
Transforming growth factor-beta-mediated proliferation of renal tubular epithelial cells involves pertussis toxin-sensitive G protein-and protein kinase C-dependent pathways.
Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways.
Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo.
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity.
Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling.
Transient Ca2+ changes in endothelial cells induced by low doses of reactive oxygen species: role of hydrogen peroxide.
Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils.
Transient inhibition of capacitative calcium entry in human neutrophils by a monoclonal antibody directed against a 19-kDa antigen.
Transition-state structure for the ADP-ribosylation of recombinant Gialpha1 subunits by pertussis toxin.
Translocation of activated heterotrimeric G protein Galpha(o) to ganglioside-enriched detergent-resistant membrane rafts in developing cerebellum.
Translocation of Activator of G-protein Signaling 3 to the Golgi Apparatus in Response to Receptor Activation and Its Effect on the trans-Golgi Network.
Transmembrane mechanochemical coupling in cardiac myocytes: novel activation of Gi by hyposmotic swelling.
Transmembrane signaling pathways involved in phagocytosis and associated activation of NADPH oxidase mediated by Fc gamma Rs in human neutrophils.
Transmembrane signalling by the N-formyl peptide receptor in stably transfected fibroblasts.
Transmembrane signalling of atrial natriuretic peptide in rat renal juxtaglomerular cells.
Transmembrane signalling pathways initiating cell growth in fibroblasts.
Treatment in hypertensive cardiac hypertrophy, II. Postreceptor events.
Treatment of bone-derived ROS 17/2.8 cells with dexamethasone and pertussis toxin enables detection of partial agonist activity for parathyroid hormone antagonists.
Treatment of human platelets with trypsin, thrombin, or collagen inhibits the pertussis toxin-induced ADP-ribosylation of a 41-kDa protein.
Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein Gi.
Treatment of intact striatal neurones with cholera toxin or 8-bromoadenosine 3',5'-(cyclic)phosphate decreases the ability of pertussis toxin to ADP-ribosylate the alpha-subunits of inhibitory and other guanine-nucleotide-binding regulatory proteins, Gi and Go. Evidence for two distinct mechanisms.
Treatment of rabbit neutrophils with phorbol esters results in increased ADP-ribosylation catalyzed by pertussis toxin and inhibition of the GTPase stimulated by fMet-Leu-Phe.
Treatment of severe pertussis: a study of the safety and pharmacology of intravenous pertussis immunoglobulin.
Treatment with pertussis toxin does not prevent central effects of eel calcitonin.
Treatment with Vitamin D/MOG Association Suppresses Experimental Autoimmune Encephalomyelitis.
Trends in Hospital Admissions for Pertussis Infection: A Nationwide Retrospective Observational Study in Italy, 2002-2016.
TRH raises cytosolic Ca2+ in human adenomatous lactotrophs.
Trial of a new acellular pertussis vaccine in healthy adult volunteers.
Trichinella spiralis: histamine secretion induced by TSL-1 antigens from unsensitized mast cells.
Tricyclic Antidepressant Amitriptyline-induced Glial Cell Line-derived Neurotrophic Factor Production Involves Pertussis Toxin-sensitive G?i/o Activation in Astroglial Cells.
Tricyclic antidepressants inhibit Ca(2+)-activated K(+)-efflux in cultured spinal cord neurons.
Triggering by ATP of product release by mucous granules of the land slug Ariolimax columbianus.
Triggering of degranulation in mast cells by exogenous type II phospholipase A2.
Triggers of autoimmune disease in a murine TCR-transgenic model for multiple sclerosis.
Triglyceride modulation by acifran analogs: activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74.
Trimer carboxyl propeptide of collagen I produced by mature osteoblasts is chemotactic for endothelial cells.
Trimeric G proteins regulate the cytosol-induced redistribution of Golgi enzymes into the endoplasmic reticulum.
Triplex real-time PCR assay for detection and differentiation of Bordetella pertussis and Bordetella parapertussis.
Trophic effect of angiotensin II in neonatal rat cardiomyocytes: role of endothelin-1 and non-myocyte cells.
Trp-Lys-Tyr-Met-Val-D-Met is a chemoattractant for human phagocytic cells.
Trp-Lys-Tyr-Met-Val-Met activates mitogen-activated protein kinase via a PI-3 kinase-mediated pathway independent of PKC.
Truncation of the carboxyl-terminal region of the rat parathyroid hormone (PTH)/PTH-related peptide receptor enhances PTH stimulation of adenylyl cyclase but not phospholipase C.
Trypanosoma brucei: characterisation of a life cycle stage-specific G-protein.
Trypanosoma cruzi: infection of cultured human endothelial cells alters inositol phosphate synthesis.
Trypsin stimulates integrin alpha(5)beta(1)-dependent adhesion to fibronectin and proliferation of human gastric carcinoma cells through activation of proteinase-activated receptor-2.
Trypsin stimulates the phosphorylation of p42,44 mitogen-activated protein kinases via the proteinase-activated receptor-2 and protein kinase C epsilon in human cultured prostate stromal cells.
Tryptamine induces phosphoinositide turnover and modulates adrenergic and muscarinic cholinergic receptor function in cultured cerebellar granule cells.
Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells.
Tryptase enhances release of vascular endothelial growth factor from human osteoarthritic chondrocytes.
Tryptase inhibits motility of human spermatozoa mainly by activation of the mitogen-activated protein kinase pathway.
TSH Activates Macrophage Inflammation by G13- and G15-dependent Pathways.
TSH Receptor Homodimerization in Regulation of cAMP Production in Human Thyrocytes in vitro.
TSH/IGF-1 Receptor Cross-talk Rapidly Activates Extracellular Signal-regulated Kinases in Multiple Cell Types.
Tumor cell autocrine motility factor receptor.
Tumor cell motility.
Tumor necrosis factor alpha 'primes' the platelet-activating factor-induced superoxide production by human neutrophils: possible involvement of G proteins.
Tumor necrosis factor alpha inhibits collagen alpha 1(I) gene expression in rat hepatic stellate cells through a G protein.
Tumor necrosis factor alpha modulates parathyroid hormone action in UMR-106-01 osteoblastic cells.
Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors.
Tumor necrosis factor induced release of endothelial cell lipoprotein lipase.
Tumor necrosis factor inhibits K+ current expression in cultured oligodendrocytes.
Tumor necrosis factor reduces cAMP production in rat microglia.
Tumor necrosis factor-alpha inhibits the cardiac delayed rectifier K current via the asphingomyelin pathway.
Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression.
Tumor necrosis factor-alpha/cachectin activates the O2(-)-generating system of human neutrophils independently of the hydrolysis of phosphoinositides and the release of arachidonic acid.
Tumor necrosis factor-mediated biological activities involve a G-protein-dependent mechanism.
Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins.
Tumour necrosis factor (cachectin) induces phospholipase A2 activity and synthesis of a phospholipase A2-activating protein in endothelial cells.
Tumour necrosis factor-alpha stimulates invasiveness of T-cell hybridomas and cytotoxic T-cell clones by a pertussis toxin-insensitive mechanism.
Tumour necrosis factor-alpha- and interleukin-1beta-stimulated cell proliferation through activation of mitogen-activated protein kinase in canine tracheal smooth muscle cells.
Tungstate-targeting of BK??1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle.
Two basic amino acids in the second inner loop of the interleukin-8 receptor are essential for Galpha16 coupling.
Two C-terminal peptides of human CKLF1 interact with the chemokine receptor CCR4.
Two different G-proteins mediate neuropeptide Y and bradykinin-stimulated phospholipid breakdown in cultured rat sensory neurons.
Two different ionotropic receptors are activated by ATP in rat microglia.
Two different P2Y receptors linked to steroidogenesis in bovine adrenocortical cells.
Two different signal transductions of neuropeptide Y1 receptor in SK-N-MC cells.
Two different signaling mechanisms involved in the excitation of rat sympathetic neurons by uridine nucleotides.
Two distinct Gi-proteins mediate formyl peptide receptor signal transduction in human leukemia (HL-60) cells.
Two distinct light regulated G-proteins in octopus photoreceptors.
Two distinct P2 purinergic receptors, P2Y and P2U, are coupled to phospholipase C in mouse pineal gland tumor cells.
Two distinct pathways in the down-regulation of type-1 angiotension II receptor gene in rat glomerular mesangial cells.
Two distinct pathways of platelet-activating factor-induced hydrolysis of phosphoinositides in primary cultures of rat Kupffer cells.
Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin.
Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.
Two human alpha 2-adrenoceptor subtypes alpha 2A-C10 and alpha 2B-C2 expressed in Sf9 cells couple to transduction pathway resulting in opposite effects on cAMP production.
Two intracellular signaling pathways for activation of protein kinase C are involved in oxidized low-density lipoprotein-induced macrophage growth.
Two isoforms of prostaglandin EP3 receptor exhibiting constitutive activity and agonist-dependent activity in Rho-mediated stress fiber formation.
Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins.
Two mechanisms of photoendocrine transduction in cultured chick pineal cells: pertussis toxin blocks the acute but not the phase-shifting effects of light on the melatonin rhythm.
Two opposite signal transducing mechanisms regulate a G-protein-coupled guanylyl cyclase.
Two phases of pseudopod protrusion in tumor cells revealed by a micropipette.
Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells.
Two types of G proteins involved in regulation of phosphoinositide turnover in pulmonary endothelial cells.
Two types of voltage-dependent calcium current in rat somatotrophs are reduced by somatostatin.
Two-Component Cluster Analysis of a Large Serodiagnostic Database for Specificity of Increases of IgG Antibodies against Pertussis Toxin in Paired Serum Samples and of Absolute Values in Single Serum Samples.
Two-pore potassium ion channels are inhibited by both G(q/11)- and G(i)-coupled P2Y receptors.
Two-step activation of T cells, clonal expansion and subsequent Th1 cytokine production, is essential for the development of clinical autoimmune encephalomyelitis.
TXA2 agonists inhibit high-voltage-activated calcium channels in rat hippocampal CA1 neurons.
Type 1 angiotensin receptor (AT1-R)-mediated decrease in type 2 angiotensin receptor mRNA level is dependent on Gq and extracellular signal-regulated kinase 1//2 in AT1-R-transfected PC12 cells.
Type 2 lysophosphatidic acid receptor in gastric surface mucous cells: Possible implication of prostaglandin E2 production.
Type A allatostatins from Drosophila melanogaster and Diplotera puncata activate two Drosophila allatostatin receptors, DAR-1 and DAR-2, expressed in CHO cells.
Type II phospholipase A2 recombinant overexpression enhances stimulated arachidonic acid release.
Type IV collagen stimulates an increase in intracellular calcium. Potential role in tumor cell motility.
Tyramine receptor (SER-2) isoforms are involved in the regulation of pharyngeal pumping and foraging behavior in Caenorhabditis elegans.
Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of ?2-adrenoceptor.
Tyrosine kinase activation by Newcastle disease virus is required for TNF-alpha gene induction in astrocytes.
Tyrosine kinase-activating growth factors potentiate thrombin- and AIF4- -induced phosphoinositide breakdown in hamster fibroblasts. Evidence for positive cross-talk between the two mitogenic signaling pathways.
Tyrosine phosphorylation and activation of Janus kinase 1 and STAT3 by sublytic C5b-9 complement complex in aortic endothelial cells.
Tyrosine phosphorylation and oxygen consumption induced by G proteins in neutrophils.
Tyrosine phosphorylation in activated human neutrophils. Comparison of the effects of different classes of agonists and identification of the signaling pathways involved.
Tyrosine phosphorylation in human neutrophil.
Tyrosine phosphorylation induced by cross-linking of Fc gamma-receptor type II in human neutrophils.
Tyrosine phosphorylation is an obligatory event in IL-2 secretion.
Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation.
Tyrosine phosphorylation is required for eosinophil degranulation induced by immobilized immunoglobulins.
Tyrosine phosphorylation of a 34-kDa protein induced by cross-linking a novel glycosylphosphatidylinositol-anchored glycoprotein (GPI-80) on human neutrophils that may regulate their adherence and migration.
Tyrosine phosphorylation of a 58 kDa protein induced by morphine in SK-N-SH cells.
Tyrosine phosphorylation of a low molecular weight protein induced by RANTES in T-lymphocytes.
Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein.
U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells.
U50,488H inhibits effects of norepinephrine in rat cardiomyocytes-cross-talk between kappa-opioid and beta-adrenergic receptors.
U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation.
UDP-glucose acting at P2Y14 receptors is a mediator of mast cell degranulation.
Ultra-low dose naloxone restores the antinocicepitve effect of morphine in PTX-treated rats: Association of IL-10 upregulation in the spinal cord.
Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway.
Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein.
Ultra-low-dose naloxone enhances the antinociceptive effect of morphine in PTX-treated rats: regulation on global histone methylation.
Ultra-low-dose naloxone restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in PTX-treated rats.
Unbinding forces of single pertussis toxin-antibody complexes measured by atomic force spectroscopy correlate with their dissociation rates determined by surface plasmon resonance.
Unchanged efficacy of a pertussis toxoid vaccine throughout the two years after the third vaccination of infants.
Uncoupling of gamma-aminobutyric acid B receptors from GTP-binding proteins by N-ethylmaleimide: effect of N-ethylmaleimide on purified GTP-binding proteins.
Undifferentiated U937 cells transfected with chemoattractant receptors: a model system to investigate chemotactic mechanisms and receptor structure/function relationships.
Unidirectional, heterologous desensitization of the pertussis toxin receptor by the CD3/TCR complex.
Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester.
Unique monoclonal antibody recognizing the third extracellular loop of CXCR4 induces lymphocyte agglutination and enhances human immunodeficiency virus type 1-mediated syncytium formation and productive infection.
Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling.
Unmasking of LPA(1) receptor-mediated migration response to lysophosphatidic acid by interleukin-1?-induced attenuation of Rho signaling pathways in rat astrocytes.
Unopposed matrix metalloproteinase-9 expression in human tuberculous granuloma and the role of TNF-alpha-dependent monocyte networks.
Unrecognized pertussis infection in adolescents.
Unsaturated fatty acids mobilize intracellular calcium independent of IP3 generation and VIA insertion at the plasma membrane.
Untangling the genetic link between type 1 and type 2 diabetes using functional genomics.
Up-regulation in late pregnancy of both Go1 alpha and Go2 alpha isoforms in human myometrium.
Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathway.
Up-regulation of human neutrophil receptors for Neisseria gonorrhoeae expressing PII outer membrane proteins.
Up-regulation of interleukin-6 in human ovarian cancer cell via a Gi/PI3K-Akt/NF-kappaB pathway by lysophosphatidic acid, an ovarian cancer-activating factor.
Up-regulation of RGS4 mRNA by opioid receptor agonists in PC12 cells expressing cloned mu- or kappa-opioid receptors.
Up-regulation of the alpha2-macroglobulin signaling receptor on rheumatoid synovial fibroblasts.
Upregulation of Na(+)-dependent alanine transport in vascular endothelial cells by serum: role of intracellular Ca2+.
Upregulation of TNF-alpha-induced ICAM-1 surface expression by adenylate cyclase-dependent pathway in human endothelial cells.
Uptake and intracellular survival of Bordetella pertussis in human macrophages.
Urinary pheromones promote ERK/Akt phosphorylation, regeneration and survival of vomeronasal (V2R) neurons.
Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons.
Urokinase potentiates PDGF-induced chemotaxis of human airway smooth muscle cells.
Urokinase-induced smooth muscle cell responses require distinct signaling pathways: a role for the epidermal growth factor receptor.
Urokinase/urokinase receptor and vitronectin/alpha(v)beta(3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways.
Urotensin-II receptor stimulation of cardiac L-type Ca2+ channels requires the ?? subunits of Gi/o-protein and phosphatidylinositol 3-kinase-dependent protein kinase C beta 1 isoform.
Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway.
Use of a Chinese hamster ovary cell cytotoxicity assay for the rapid diagnosis of pertussis.
Use of biotinylated NAD to label and purify ADP-ribosylated proteins.
Use of chemokine receptors by poxviruses.
Use of constitutive G protein-coupled receptor activity for drug discovery.
Use of cyclodextrin as an agent to induce excretion of Bordetella pertussis antigens.
Use of erythromycin to prevent pertussis in newborns of mothers with pertussis.
Use of fluoride ion as a probe for the guanine nucleotide-binding protein involved in the phosphoinositide-dependent neutrophil transduction pathway.
Use of G-protein coupled and uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants.
Use of glycosyltransferases to restore pertussis toxin receptor activity to asialoagalactofetuin.
Use of implantable intraperitoneal diffusion chambers to study Bordetella pertussis pathogenesis: growth and toxin production in vivo.
Use of pertussis toxin encoded by ptx genes from Bordetella bronchiseptica to model the effects of antigenic drift of pertussis toxin on antibody neutralization.
Use of pertussis toxin to investigate the mechanism of action of prostaglandin F2 alpha on the corpus luteum in sheep.
Use of replication-deficient adenoviruses to study signal transduction pathways. Muscarinic responses in HSG and HT29 epithelial cell lines are mediated by G protein betagamma-subunits.
Use of RGS-insensitive Galpha subunits to study endogenous RGS protein action on G-protein modulation of N-type calcium channels in sympathetic neurons.
Use of synthetic peptides to map antigenic sites of Bordetella pertussis toxin subunit S1.
Use of the Membrane Invasion Culture System (MICS) as a screen for anti-invasive agents.
Use of the promoter fusion transposon Tn5 lac to identify mutations in Bordetella pertussis vir-regulated genes.
Use of type I and type IV hypersensitivity responses to define the immunopharmacological profile of drugs.
Usefulness of laboratory methods in diagnosis of pertussis in adult with paroxysmal cough.
Utilization of sialic acid-binding synthetic peptide sequences derived from pertussis toxin as novel anti-inflammatory agents.
V642I APP-inducible neuronal cells: a model system for investigating Alzheimer's disorders.
Vaccination against the gastrointestinal nematode, Haemonchus contortus, using a purified larval surface antigen.
Vaccination of infants with a four-dose and a three-dose vaccination schedule.
Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice.
Vaccination with pertussis toxin alters the antibody response to simultaneous respiratory syncytial virus challenge.
Vaccine acquired pertussis immunity was weakened at 4 years of age and asymptomatic pertussis infection was suspected based on serological surveillance.
Vaccine- and antigen-dependent type 1 and type 2 cytokine induction after primary vaccination of infants with whole-cell or acellular pertussis vaccines.
Vaccines, emerging viruses, and how to avoid disaster.
Vacuolation Activity and Intracellular Trafficking of ArtB, the Binding Subunit of an AB5 Toxin Produced by Salmonella enterica Serovar Typhi.
Validation of nested Bordetella PCR in pertussis vaccine trial.
Validation of the toxin-binding inhibition (ToBI) test for the estimation of the potency of the tetanus toxoïd component in vaccines.
Valproic Acid Attenuates Disease Symptoms and Increases Endogenous Myelin Repair by Recruiting Neural Stem Cells and Oligodendrocyte Progenitors in Experimental Autoimmune Encephalomyelitis.
Vanadate causes synthesis of endothelium-derived NO via pertussis toxin-sensitive G protein in pigs.
Vanadate changes Ca2+ influx pathway properties in human red blood cells.
Vanadate-induced oscillatory inward Cl- currents in Xenopus laevis oocytes.
Variation in the Bordetella pertussis virulence factors pertussis toxin and pertactin in vaccine strains and clinical isolates in Finland.
Variations in guanine-binding proteins (Gs, Gi) in cultured bovine adrenal cells. Consequences on the effects of phorbol ester and angiotensin II on adrenocorticotropin-induced and cholera-toxin-induced cAMP production.
Varying expression of opioid receptors and GTP-binding proteins in human pheochromocytomas.
Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis.
Vascular beta-adrenoceptor blocking activity of endotoxin and pertussis toxin from Bordetella pertussis in rats.
Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta.
Vascular endothelial growth factor production in human prostate cancer cells is stimulated by overexpression of platelet 12-lipoxygenase.
Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme.
Vascular insulin/insulin-like growth factor-1 resistance in female obese Zucker rats.
Vascular smooth muscle migration and proliferation in response to lysophosphatidic acid (LPA) is mediated by LPA receptors coupling to Gq.
Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling.
Vascular smooth muscle proliferation: synergistic interaction between serotonin and low density lipoproteins.
Vascular smooth muscle: availability of calcium through alpha-adrenoceptor stimulation.
Vascular vasopressin receptors mediate phosphatidylinositol turnover and calcium efflux in an established smooth muscle cell line.
Vasoactive intestinal peptide and epidermal growth factor: co-mitogens or inhibitors of keratinocyte proliferation in vitro?
Vasoactive intestinal peptide is a secretagogue in bovine chromaffin cells pretreated with pertussis toxin.
Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2.
Vasoactive intestinal polypeptide modulates GABAA receptor function through activation of cyclic AMP.
Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones.
Vasodilator signals from the ischemic myocardium are transduced to the coronary vascular wall by pertussis toxin-sensitive G proteins: a new experimental method for the analysis of the interaction between the myocardium and coronary vessels.
Vasopressin activates phospholipase D through pertussis toxin-insensitive GTP-binding protein in aortic smooth muscle cells: function of Ca2+/calmodulin.
Vasopressin and amastatin induce V(1)-receptor-mediated suppression of excitatory transmission in the rat parabrachial nucleus.
Vasopressin and protein kinase A activate G protein-sensitive epithelial Na+ channels.
Vasopressin induces arachidonic acid release through pertussis toxin-sensitive GTP-binding protein in aortic smooth muscle cells: independence from phosphoinositide hydrolysis.
Vasopressin induces breakdown of phosphoinositides in adrenal tumor Y-1 cells without a steroidogenic effect.
Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10.
Vasopressin rapidly stimulates protein kinase C in digitonin-permeabilized Swiss 3T3 cells: involvement of a pertussis toxin-insensitive guanine nucleotide binding protein.
Vasopressin regulates adrenal functions by acting through different vasopressin receptor subtypes.
Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA.
Vasopressin V1 receptors on the principal cells of the rabbit cortical collecting tubule. Stimulation of cytosolic free calcium and inositol phosphate production via coupling to a pertussis toxin substrate.
Vasopressin-induced currents in rat neonatal spinal lateral horn neurons are G-protein mediated and involve two conductances.
Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor.
Vectors to achieve selective expression of vaccine antigens within eukaryotic cells using Salmonella spp. as carrier strains.
Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.
Verapamil has antiarrhythmic effects that are mediated in brain through endogenous opioids.
Violet Light Down-Regulates the Expression of Specific Differentiation Markers through Rhodopsin in Normal Human Epidermal Keratinocytes.
VIP activates G(s) and G(i3) in rat alveolar macrophages and G(s) in HEK293 cells transfected with the human VPAC(1) receptor.
VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation.
VIP inhibits N-type Ca2+ channels of sympathetic neurons via a pertussis toxin-insensitive but cholera toxin-sensitive pathway.
Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells.
Virulence factor secretion and translocation by Bordetella species.
Virulence factors of Bordetella pertussis.
Virulence of Bordetella bronchiseptica: role of adenylate cyclase-hemolysin.
Virus stimulation of human mast cells results in the recruitment of CD56+ T cells by a mechanism dependent on CCR5 ligands.
Visible light exposure induces VEGF gene expression through activation of retinoic acid receptor-alpha in retinoblastoma Y79 cells.
Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.
Visualization of muscarinic cholinergic receptors on chick cardiomyocytes and their involvement in phosphatidylcholine hydrolysis.
Vitamin D receptor-dependent 1 alpha,25(OH)2 vitamin D3-induced anti-apoptotic PI3K/AKT signaling in osteoblasts.
Voltage- and ligand-activated inwardly rectifying currents in dorsal raphe neurons in vitro.
Voltage- and time-dependent inhibition of neuronal calcium channels by a GTP-binding protein in a mammalian cell line.
Voltage-dependent calcium channels and Gi regulatory protein mediate the human sperm acrosomal exocytosis induced by N-acetylglucosaminyl/mannosyl neoglycoproteins.
Voltage-Dependent Dopamine Potency at D1-Like Dopamine Receptors.
Voltage-dependent inhibition of Ca2+ channels in GH3 cells by cloned mu- and delta-opioid receptors.
Voltage-dependent noradrenergic modulation of omega-conotoxin-sensitive Ca2+ channels in human neuroblastoma IMR32 cells.
Voltage-dependent, pertussis toxin insensitive inhibition of calcium currents by histamine in bovine adrenal chromaffin cells.
Voltage-Gated R-Type Calcium Channel Inhibition via Human ?-, ?-, and ?-opioid Receptors Is Voltage-Independently Mediated by G?? Protein Subunits.
Voltage-independent autocrine modulation of L-type channels mediated by ATP, opioids and catecholamines in rat chromaffin cells.
Volume-activated taurine transport is differentially activated in human cervical cancer HT-3 cells but not in human papillomavirus-immortalized Z183A and normal cervical epithelial cells.
Voluntary exercise-induced changes in beta2-adrenoceptor signalling in rat ventricular myocytes.
Waning vaccine immunity and vaccination responses in children treated for acute lymphoblastic leukemia: A Canadian Immunization Research Network Study.
WAY208466 inhibits glutamate release at hippocampal nerve terminals.
Western blot analysis of antibody responses of young infants to pertussis infection.
What to do and what not to do in serological diagnosis of pertussis: recommendations from EU reference laboratories.
Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination.
Whole-cell calcium current in guinea-pig ventricular myocytes dialysed with guanine nucleotides.
Whole-cell Cl- currents in a human peripheral airway epithelial cell line.
Whole-cell recordings of inwardly rectifying K+ currents activated by 5-HT1A receptors on dorsal raphe neurones of the adult rat.
Whooping cough and Parkinson's disease. The Europarkinson Preparatory Activity Research Group.
Whooping Cough in Adults: A Series of Severe Cases.
Why are several inhibitory transmitters present in the innervation of pituitary melanotrophs? Actions and interactions of dopamine, GABA and neuropeptide Y on secretion from neurointermediate lobes of Xenopus laevis.
Widespread distribution of Gq alpha/G11 alpha detected immunologically by an antipeptide antiserum directed against the predicted C-terminal decapeptide.
Widespread silent transmission of pertussis in families: antibody correlates of infection and symptomatology.
Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model.
Withdrawal of somatostatin augments L-type Ca2+ current in primary cultured rat somatotrophs.
WNT-3A-induced ?-catenin signaling does not require signaling through heterotrimeric G proteins.
Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion.
WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.
Wnt3a stimulation elicits G-protein-coupled receptor properties of mammalian Frizzled proteins.
Workshop on Animal free Detection of Pertussis Toxin in Vaccines--Alternatives to the Histamine Sensitisation Test.
Wortmannin-sensitive activation of p70s6k by endogenous and heterologously expressed Gi-coupled receptors.
Xaliproden (SR57746A) induces 5-HT1A receptor-mediated MAP kinase activation in PC12 cells.
Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled ?2-adrenergic signaling.
Y2 receptors for neuropeptide Y are coupled to three intracellular signal transduction pathways in a human neuroblastoma cell line.
YtxR, a conserved LysR-like regulator that induces expression of genes encoding a putative ADP-ribosyltransferase toxin homologue in Yersinia enterocolitica.
Zebrafish Mir antagonizes Frizzled 7-induced gastrulation defects.
Zinc hydroxide induced respiratory burst in rat neutrophils.
Zinc hydroxide stimulates superoxide production by rat alveolar macrophages.
Zona pellucida induces activation of phospholipase A2 during acrosomal exocytosis in guinea pig spermatozoa.
[3H]-BIBP3226 and [3H]-NPY binding to intact SK-N-MC cells and CHO cells expressing the human Y1 receptor.
[3H]GDP release from rat and hamster adipocyte membranes independently linked to receptors involved in activation or inhibition of adenylate cyclase. Differential susceptibility to two bacterial toxins.
[A field survey carried out on the confirmation of a pertussis case in a village of Kirikkale Province, Turkey]
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment]
[A polyvalent complex of Bordetella pertussis antigens as the basis for an acellular pertussis vaccine]
[A study of the ability of Bordetella pertussis toxin to induce the formation of B-suppressors]
[Abnormalities in the beta-adrenergic receptor-adenylate cyclase system in the ventricular myocardium of spontaneously hypertensive rats]
[Acellular pertussis vaccines--safe alternative]
[Activation mechanisms by thrombin and vasopressin of fibroblasts in spontaneously hypertensive rats]
[Activation of p38 and c-Jun NH2-terminal kinase mitogen-activated protein kinases in human prostate carcinoma cell lines with different metastatic potentials]
[Analysis of the nature of responses of neurons of rat spinal ganglia evoked by the activation of GABA-B receptors]
[Antigenic composition and serologic characteristics of domestic acellular pertussis vaccine]
[Antigenic variability of Bordetella pertussis strains isolated in 1967-2010 in the Czech Republic--possible explanation for the rise in cases of pertussis?].
[Biological behavior of SDF-1/CXCR4 in patients with myelodysplastic syndrome].
[Bordetella pertussis lipooligosaccharide-derived neoglycoconjugates - new components of pertussis vaccine].
[Ca2+]i oscillations induced by high [K+]o in acetylcholine-stimulated rat submandibular acinar cells: regulation by depolarization, cAMP and pertussis toxin.
[Ca2+]i rises via G protein during regulatory volume decrease in rabbit proximal tubule cells.
[Ca2+]i-transients and actin polymerization in human neutrophils under stimulation with GRO alpha and complement fragment C5a.
[Calcium-independent inhibition of the spontaneous release of GABA by baclofen in the rat hippocampus]
[Can the determination of IgG antibodies to the pertussis toxin help the diagnosis of the disease?]
[Cellular and acellular anti-pertussis vaccines]
[Characterization of adrenal medullary opioid receptors. II. Coupling of adrenal medullary opioid receptors to GTP binding proteins]
[Chemoattractive effects of chemokine-like factor 1 on human arterial smooth muscle cells.]
[Chemotactic and mitogenic effect of rat chemokine-like factor 1 on aortic smooth muscle cells.]
[Cloning and expression of subunit genes of pertussis toxin and its immunological evaluation]
[Cloning and gene expression of the leukocytosis (lymphocytosis) stimulating factor of Bordatella pertussis in Escherichia coli by bringing the PT genes close to the lactose promoter of plasmid pUC19]
[Comparison of routine serological investigations performed in three different laboratories in Poland for the diagnosis of pertussis]
[Construction of the genetically attenuated bacteria Aordetella pertussis devoid of dermonecrotic toxin activity and producing modified nontoxic pertussis toxin form]
[Contents of antibodies to Bordetella pertussis antigens in patients with rheumatic diseases]
[Coupling of GTP-binding protein to inositol phospholipid metabolism in chemoattractant-stimulated guinea pig peritoneal exudate macrophages]
[Coupling of guanine nucleotide inhibitory protein to somatostatin receptors on rat pancreatic acinar membranes]
[Cytomorphological and enzymocytochemical studies of tissue cultures treated with pertussis toxin]
[Demonstration of the immunostimulating component(s) in Bordetella pertussis (Phase I, strain Tohama), other than cell wall peptidoglycan, endotoxic lipopolysaccharide and pertussis toxin]
[Detection of the gene sequences of the leukocytosis (lymphocytosis)-stimulating factor of Bordetella pertussis in Bordetella parapertussis and Bordetella bronchiseptica by using molecular hybridization]
[Determination of tracheal cytotoxin in pertussis and diphtheria tetanus acellular pertussis vaccines using liquid chromatography-tandem mass spectrometry].
[Development and optimization of an in-house PCR method for molecular diagnosis of pertussis].
[Development of a method for the quantitative determination of Bordetella pertussis toxin and the prospects of its use for diagnosis]
[Development of a time-resolved fluoroimmunoassay for detecting S1 subunit of pertussis toxin and its application].
[Diagnosis of whooping cough by serology and real-time PCR].
[Diagnostic value of IgG, IgA, and IgM to Bordetella pertussis antigens in patients with pertussis]
[Domestic acellular pertussis vaccine]
[Effect of bacterial toxins on the GTPase activity of transducin from bovine rod outer segments]
[Effect of bacterial toxins on the mitogen-induced increase of the Ca2+ concentration in the cytoplasm of rat thymocytes. The role of N proteins]
[Effect of ET-1 on intracellular free calcium in cultured neonatal myocardial cells]
[Effect of interleukin-2 on intracellular calcium transients in rat ventricular myocytes]
[Effect of interleukin-2 on the activity of Ca(2+)ATPase and Na(+)/K(+)ATPase of sarcoplasmic reticulum and sarcolemma]
[Effect of pertussis toxin on cells cultivated in vitro.]
[Effect of solution environment on the purification of pertussis toxin]
[Effects of G-Protein Regulators and Stylar S-RNase on the Growth and Ca(2+) Concentration of Pyrus pyrifolia Pollen Tube.]
[Effects of lithium and antidepressants on monoaminergic receptors and receptor-coupled adenylate cyclase system in rat brain]
[Effects of matrix metalloproteinase-9 inhibitor in Lewis rats with experimental autoimmune myocarditis.]
[Effects of praeruptorin C on cell hypertrophy, intracellular [Ca2+]i, nitric oxide and signal transduction in isolated hypertrophied rat smooth muscle cells induced by angiotensin II]
[Effects of sphingosine-1-phosphate, a lipid mediator, in cardiovascular tissues]
[Endothelial dysfunction and atherosclerosis]
[Engineering of attenuated Bordetella pertussis bacteria producing immunogenic non-toxic form of pertussis toxin]
[Eosinophil and neutrophil degranulation in allergic inflammation: immunohistochemical localization of granule proteins in fatal asthma and stimulus-dependent degranulation in vitro]
[Evaluation of Bordetella pertussis strains toxicity in vitro using CHO cell lines].
[Evaluation of G(i/o) protein signal transduction pathway in cardioprotection of hypoxic preconditioning]
[Evaluation of the usefulness of Bordetella pertussis toxins for serodiagnosis of whooping cough]
[Evaluation of whole-cell and acellular pertussis vaccines effectiveness in clearance of experimental B. pertussis infection in mice]
[Facilitatory actions of the cognitive enhancer nefiracetam on neuronal Ca2+ channels and nicotinic ACh receptors: their intracellular signal transduction pathways]
[Features of Bordetella pertussis, Bordetella spp. infection and whopping cough in Córdoba province, Argentina].
[Features of expression of the pertussis toxin operon under the control of its own and heterologous promotors in Bordetella bronchiseptica cells]
[Functional characteristics of nucleotide-receptors in human neutrophils]
[Functional guanine nucleotide-binding proteins in receptor-mediated modulation of voltage-dependent ion channels]
[G(i) proteins in regulation of water permeability of the rat kidney collecting tube epithelium cell membrane]
[Genetic variability of Bordetella pertussis strains. Part I. Current knowledge]
[Genetic variability of Bordetella pertussis strains. Part II. Perspectives]
[Goniodomin A induces modulation of actomyosin ATPase activity mediated through conformational change of actin]
[Growth and invasion of differentiated thyroid gland carcinoma: importance of signal transduction]
[Health Council of the Netherlands advisory report 'Vaccination against pertussis'--time for a new vaccine]
[Hormone-like action of blood plasma lipoproteins on human platelets and smooth vascular muscle cells]
[Humoral imunity to pertussis in children with diabetes of type 1]
[Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. I. Antibody level for B pertussis antigens in children without respiratory tract infection symptoms]
[Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. II. Occurence and level of B. pertussis antigens in children with suspected whooping cough]
[Humoral response to the injection of acellular Pertussis vaccine]
[Hybridomas synthesizing monoclonal antibodies to Bordetella pertussis toxins]
[Identification and isolation of GTP-binding regulator protein from plasma membranes of oocytes from the starfish Asterias amurensis]
[Identification and purification of GTP-binding regulatory proteins from plasma membranes of swine heart]
[Immunobiologic activity of Bordetella pertussis strains defective in various virulence factors]
[Immunogenicity and safety of Di-Te-Ki-Pol vaccine "SSI" in Danish infants]
[Immunogenicity and safety of vaccine preparations based on circulating Bordetella pertussis strains].
[Immunological effect of systemically administered allopurinol in experimental autoimmune uveitis]
[Impairment of atypical beta-adrenergic-mediated relaxation in spontaneously hypertensive rats before and during the development of arterial hypertension]
[In vitro study of endothelium-dependent relaxation and contraction of human atherosclerotic femoral artery]
[Inactivation and toxoiding of biologically-active components of Bordetella pertussis by tea catechins]
[Increase of intradermal vascular permeability by pertussis toxin]
[Induction of protective immunity for Bordetella pertussis by nasal inoculation of pertussis vaccine in mice]
[Influence of pertussis toxin on GPER-mediated activation of phosphatidylinositol 3-kinase/protein kinase B signaling induced by 17?-estradiol in endometrial carcinoma cells].
[Inhibiting effect of ADP-ribosylation by pertussis toxin on passive transport of Ca2+ into the cell membrane of porcine myometrium]
[Inhibitory effect of pertussis toxin on the metabolism of guanine nucleotides in transducin from bovine outer rod segments]
[Intracellular messengers in the regulation of renin secretion]
[Intracellular signal transmission of low density lipoprotein receptors in human monocytes]
[Involvement of G proteins between receptors and KCa channels in the regulation of airway tone by the autonomic nervous system]
[Isolation of hemolytic cultures of Bordetella pertussis intended for the production of acellular pertussis preparations and the characterization of their biological properties]
[Isoproterenol, denopamine, and atenolol-induced alterations in beta-adrenergic receptor-adenylate cyclase system of rat myocardium]
[Kainate receptors. Their function in the regulation of GABAergic synaptic transmission in the hippocampus]
[Laboratory diagnosis of pertussis. Role of serology]
[Localization of segments in the Gs protein interacting with adenylate cyclase using a Gs/G0-chimera]
[Macrophage depletion inhibits leukocyte recruitment in experimental melanin-induced uveitis (EMIU)]
[Mechanism of carbachol and adenosine action on spontaneous quantal mediator release at frog neuromuscular junction]
[Mechanism of the activation of extracellular signal-regulated kinase (ERK) in prostate cancer cell lines with different metastatic potential]
[Mechanisms of opioid receptor-induced elevation in intracellular calcium by confocal laser scanning microscopy]
[Membrane receptors and coupling proteins in adenohypophyseal cells]
[Metabolic and ionic dependence of neuronal responses evoked by serotonin in the rat sensory ganglia]
[Modern strains of Bordetella pertussis: immunobiological properties and vaccine improvement]
[Modulation of the action of interferon-gamma by protein G]
[Molecular genetic characteristics of the B. pertussis strains isolated in different periods of the pertussis epidemic process]
[Multispecific monoclonal antibodies]
[Noradrenaline-induced alterations in beta-adrenergic receptor-adenylate cyclase system of rat myocardium]
[Novel approaches to control the rise in pertussis cases].
[Pathogenetic significance of Bordetella pertussis toxin]
[Pathways of signal transduction of intracellular Ca2+ increase mediated by three subtypes of alpha 1-adrenoceptor in HEK293 cells]
[Pertussis outbreak in a poorly immunized community]
[Pertussis seroprevalence and vaccination status in three selected province of Turkey]
[Pertussis toxin and cross-reactive antigens in dynamics of Bordetella pertussis cultivation]
[Pertussis toxin stimulates brain adenyl cyclase and induces ADP ribosylation of a 40,000 dalton membrane protein]
[Pharmacological characterization of alpha 2-adrenoceptor regulated 5-HT release in the rat hippocampus]
[Physicochemical and biological characteristics of preparations of an antigenic complex isolated from the cultivation medium of Bordetella pertussis]
[Physiopathological role of low affinity IgE receptor (CD23) in hematopoietic cells]
[Production of pertussis toxin by Bordetella pertussis strains isolated from patients with whooping cough].
[Prophylaxis of pertussis: development and use of acellular pertussis vaccine]
[Prostaglandin E2 receptor and GTP binding protein in the normal and nephrotic rat kidney]
[Protection and its mechanism of catechin morphon on hypoxia-reoxynation induced injury in myocardial cells]
[Protective activity of tea and catechins against Bordetella pertussis]
[Purification and properties of Bordetella pertussis toxin]
[Receptor-mediated signal transduction]
[Regulation by cations of adenylate cyclase activity in chicken tissues]
[Regulation mechanisms of receptors mediated activation of phospholipase c and inositol-1,4,5-triphosphate sensitive Ca2+ release and Ca2+ uptake in exocrine glandular cells]
[Regulation of adenylyl cyclase signaling system by insulin, biogenic amines, and glucagon at their separate and combined action in the muscle membranes of the mollusc Anodonta cygnea].
[Regulation of inositol-1,4,5-triphosphate receptor by G(i)-protein]
[Reorganization of microtubule system in pulmonary endothelial cells in response to thrombin treatment]
[Role of a guanine nucleotide regulatory protein in exocrine pancreatic secretion--effects of cholera toxin and pertussis toxin on cholecystokinin action]
[Role of sphingosine 1-phosphate receptor signaling in hematopoietic stem/progenitor cell transmigration.]
[ROLE PHOSPHOINOSITID SIGNALING PATHWAY IN OPIOIDS CONTROL OF P2X3 RECEPTORS IN THE PRIMARY SENSORY NEURONS].
[Seroepidemiological Studies on Pertussis, Diphtheria and Tetanus among Nursing Students Enrolled between 1994 and 2011 in the Kitakyushu District].
[Seroepidemiology of pertussis in 10-15 years old healthy children in Isparta province, Turkey].
[Seroprevalence of pertussis toxin antibody in Manisa province of Turkey, after six years implementation of acellular pertussis vaccine].
[Serum immunoglobulin IgG subclass distribution of antibody responses to pertussis toxin and filamentous hemagglutinin of Bordetella pertussis in patients with whooping cough].
[Signal transduction of prostaglandin E2 and thromboxane A2]
[Structural organization of a segment of chromosome, containing the vir gene of Bordetella pertussis]
[Studies of the reaction of the living body to pertussis vaccine, with special reference to electromyographic experiments with the intercostal muscles. II. Electromyogram of the intercostal muscles by inoculation with Hemophilus pertussis type I and Hemophilus pertussis toxin after Hemophilus pertussis vaccination.]
[Studies on the toxins of Bordetella pertussis. 7. Investigation by sedimentation analysis of some methods of detoxication of pertussis toxin.]
[Studies on the toxins of Bordetella pertussis. 8. Pathohistologic studies on all organs of mice inoculated with pertussis toxin.]
[Study on pertussis using nerve tissue culture. 2. Study on the influence of pertussis toxin on cultured nerve elements]
[Suppression of platelet activating factor effects (PAF) on the retina by G-proteins inhibitors]
[Synthesis of monoclonal antibodies to tissue-specific antigens of human skin and thymus epithelium in polyclonal activation by pertussis toxin]
[The Clinical Signs of Experimental Autoimmune Uveitis].
[The development of a new generation of pertussis vaccine]
[The development of a process for culturing Bordetella pertussis immobilized on a polyurethane carrier]
[The discovery of neuromedin U and its pivotal role in the central regulation of energy homeostasis].
[The effect of cortisol and pertussis toxin on the cyclic AMP level in human lymphocytes]
[The effect of G protein regulator on pollen germination and [Ca2+]i variation in Pyrus serotina Rehd. pollen.]
[The effect of methylated cyclodextrin on pertussis toxin accumulation in a Bordetella pertussis culture in a bioreactor]
[The elastin-laminin receptor]
[The frequency of detection of IgA, IgG and IgM antibodies to pertussis toxin in patients with respiratory tract infections in Poland]
[The involvement of muscarinic M1 receptor in the regulation of action potentials in mouse isolated right atria]
[The phenotypic properties of freshly isolated strains of Bordetella]
[The risk of pertussis and diphtheria infections among pediatric healthcare workers in Japan]
[The role of a GTP-binding protein in coupling of a muscarinic cholinergic receptor and Na,K-ATPase in myocardial sarcolemma]
[The role of different subtypes of G protein in the secretory function of macrophages stimulated by activated complement following severe burn injury]
[The role of G protein, protein kinase C and Na(+)-H+ exchanger in endothelin-1-induced cardiomyocyte hypertrophic responses]
[The standardization of the in-vitro tetanus toxin neutralization test on Chinese hamster ovary cells]
[Thiol reagent thimerosal-induced Ca2+ mobilization in isolated guinea pig cochlear outer hair cells]
[Trial of pertussis toxin activity in vitro on CHO cells]
[Use of an immunoblotting method for identifying the individual proteins in the antigenic complexes of Bordetella pertussis]
{beta}-adrenergic activation of electrogenic K+ and Cl- secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways.
{delta} Opioid Receptors Stimulate Akt-Dependent Phosphorylation of c-jun in T Cells.
Wound Infection
Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections.
Pseudomonas aeruginosa strains obtained from patients with tracheal, urinary tract and wound infection: variations in virulence factors and virulence genes.
Xeroderma Pigmentosum
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.
Kinetics and thermodynamics of zinc(II) and arsenic(III) binding to XPA and PARP-1 zinc finger peptides.
PARP10 deficiency manifests by severe developmental delay and DNA repair defect.
Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair.
Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair.
Xeroderma Pigmentosum Group A Promotes Autophagy to Facilitate Cisplatin Resistance in Melanoma Cells through the Activation of PARP1.
Zika Virus Infection
ADP-ribosyltransferase PARP11 suppresses Zika virus in synergy with PARP12.
PARP-1 mediated cell death is directly activated by ZIKV infection.