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UDP-alpha-D-galactose + 1-O-(11-phenoxyundecyl-diphosphoryl)-alpha-D-glucopyranoside
UDP + 1-O-(11-phenoxyundecyl-diphosphoryl)-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside
UDP-alpha-D-galactose + 1-O-(16-phenoxyhexadecyl-diphosphoryl)-alpha-D-glucopyranoside
UDP + 1-O-(16-phenoxyhexadecyl-diphosphoryl)-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside
UDP-alpha-D-galactose + 1-O-(6-phenoxyhex-1-yl-diphosphoryl)-alpha-D-glucopyranoside
UDP + 1-O-(6-phenoxyhexadecyl-diphosphoryl)-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside
synthetic substrate, which is an analog of N-acetyl-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol. The enzyme does not require a specific length of the lipid chain but can act on GlcNAc-alpha-PO3-PO3-(CH2)R-OPh substrates where R can be 6, 11 or 16 carbons
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?
UDP-alpha-D-galactose + GlcNAc-alpha-PO3-PO3-(CH2)11-O-phenyl
UDP + D-Gal-beta-(1->3)-GlcNAc-alpha-PO3-PO3-(CH2)11-O-phenyl
UDP-alpha-D-galactose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-beta-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol
additional information
?
-
UDP-alpha-D-galactose + 1-O-(11-phenoxyundecyl-diphosphoryl)-alpha-D-glucopyranoside
UDP + 1-O-(11-phenoxyundecyl-diphosphoryl)-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside
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synthetic substrate, which is an analog of N-acetyl-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol
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-
?
UDP-alpha-D-galactose + 1-O-(11-phenoxyundecyl-diphosphoryl)-alpha-D-glucopyranoside
UDP + 1-O-(11-phenoxyundecyl-diphosphoryl)-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside
synthetic substrate, which is an analog of N-acetyl-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol. The enzyme does not require a specific length of the lipid chain but can act on GlcNAc-alpha-PO3-PO3-(CH2)R-OPh substrates where R can be 6, 11 or 16 carbons
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?
UDP-alpha-D-galactose + 1-O-(11-phenoxyundecyl-diphosphoryl)-alpha-D-glucopyranoside
UDP + 1-O-(11-phenoxyundecyl-diphosphoryl)-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside
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synthetic substrate, which is an analog of N-acetyl-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol
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-
?
UDP-alpha-D-galactose + 1-O-(11-phenoxyundecyl-diphosphoryl)-alpha-D-glucopyranoside
UDP + 1-O-(11-phenoxyundecyl-diphosphoryl)-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside
synthetic substrate, which is an analog of N-acetyl-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol. The enzyme does not require a specific length of the lipid chain but can act on GlcNAc-alpha-PO3-PO3-(CH2)R-OPh substrates where R can be 6, 11 or 16 carbons
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-
?
UDP-alpha-D-galactose + 1-O-(16-phenoxyhexadecyl-diphosphoryl)-alpha-D-glucopyranoside
UDP + 1-O-(16-phenoxyhexadecyl-diphosphoryl)-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside
synthetic substrate, which is an analog of N-acetyl-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol. The enzyme does not require a specific length of the lipid chain but can act on GlcNAc-alpha-PO3-PO3-(CH2)R-OPh substrates where R can be 6, 11 or 16 carbons
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-
?
UDP-alpha-D-galactose + 1-O-(16-phenoxyhexadecyl-diphosphoryl)-alpha-D-glucopyranoside
UDP + 1-O-(16-phenoxyhexadecyl-diphosphoryl)-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside
synthetic substrate, which is an analog of N-acetyl-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol. The enzyme does not require a specific length of the lipid chain but can act on GlcNAc-alpha-PO3-PO3-(CH2)R-OPh substrates where R can be 6, 11 or 16 carbons
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-
?
UDP-alpha-D-galactose + GlcNAc-alpha-PO3-PO3-(CH2)11-O-phenyl
UDP + D-Gal-beta-(1->3)-GlcNAc-alpha-PO3-PO3-(CH2)11-O-phenyl
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synthetic substrate, which is an analog of N-acetyl-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol
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-
?
UDP-alpha-D-galactose + GlcNAc-alpha-PO3-PO3-(CH2)11-O-phenyl
UDP + D-Gal-beta-(1->3)-GlcNAc-alpha-PO3-PO3-(CH2)11-O-phenyl
-
synthetic substrate, which is an analog of N-acetyl-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol
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-
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-beta-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol
the enzyme is involved O7 lipopolysaccharide biosynthesis
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?
UDP-alpha-D-galactose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-beta-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol
the enzyme is specific for UDP-galactose as donor substrate
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?
UDP-alpha-D-galactose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-beta-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol
the enzyme is involved O7 lipopolysaccharide biosynthesis
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-
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-beta-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol
the enzyme is specific for UDP-galactose as donor substrate
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-
?
additional information
?
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WbbD require at least one phosphate in the acceptor substrate which has to be directly linked to GlcNAc, and ise optimally active when GlcNAc is linked to diphosphate. No glycosyl transfer is observed with cytidine-monophosphate N-acetylneuraminic acid, UDP-GalNAc, GDP-Man or UDP-GlcNAc. WbbD does not recognize GlcNAc linked to a glycopeptide
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?
additional information
?
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WbbD require at least one phosphate in the acceptor substrate which has to be directly linked to GlcNAc, and ise optimally active when GlcNAc is linked to diphosphate. No glycosyl transfer is observed with cytidine-monophosphate N-acetylneuraminic acid, UDP-GalNAc, GDP-Man or UDP-GlcNAc. WbbD does not recognize GlcNAc linked to a glycopeptide
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Montoya-Peleaz, P.J.; Riley, J.G.; Szarek, W.A.; Valvano, M.A.; Schutzbach, J.S.; Brockhausen, I.
Identification of a UDP-Gal: GlcNAc-R galactosyltransferase activity in Escherichia coli VW187
Bioorg. Med. Chem. Lett.
15
1205-1211
2005
Escherichia coli, Escherichia coli VW187
brenda
Riley, J.G.; Menggad, M.; Montoya-Peleaz, P.J.; Szarek, W.A.; Marolda, C.L.; Valvano, M.A.; Schutzbach, J.S.; Brockhausen, I.
The wbbD gene of E. coli strain VW187 (O7:K1) encodes a UDP-Gal: GlcNAcalpha-pyrophosphate-R beta1,3-galactosyltransferase involved in the biosynthesis of O7-specific lipopolysaccharide
Glycobiology
15
605-613
2005
Escherichia coli, Escherichia coli VW187
brenda
Brockhausen, I.; Riley, J.G.; Joynt, M.; Yang, X.; Szarek, W.A.
Acceptor substrate specificity of UDP-Gal:GlcNAc-R beta1,3-galactosyltransferase (WbbD) from Escherichia coli O7:K1
Glycoconj. J.
25
663-673
2008
Escherichia coli (Q03084), Escherichia coli VW187 (O7:K1) (Q03084)
brenda
Brockhausen, I.; Szarek, W.A.; Riley, J.G.; Vlahakis, J.Z.
Assay for a galactosyltransferase involved in the assembly of the O7-antigen repeat unit of Escherichia coli
Methods Mol. Biol.
347
253-264
2006
Escherichia coli, Escherichia coli VW187
brenda