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(R)-citryl-CoA + H2O
citrate + CoA
Clostridium acidi-urici
-
-
-
r
(R)-malyl-CoA + H2O
(R)-malate + CoA
Clostridium acidi-urici
-
-
-
r
acetyl-CoA + H2O + oxaloacetate
(R)-citrate + CoA
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
additional information
?
-
acetyl-CoA + H2O + oxaloacetate
(R)-citrate + CoA
-
specific substrates
-
-
?
acetyl-CoA + H2O + oxaloacetate
(R)-citrate + CoA
-
specific substrates
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
Clostridium acidi-urici
-
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
Clostridium acidi-urici
-
no activity with propionyl-CoA, glyoxylate, pyruvate, 2-oxobutyrate, 2-oxoglutarate, 2-oxoisovalerate and 2-oxoisocaproate
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
Clostridium acidi-urici
-
stereospecific for (R)-citrates, no change from (R)-type to (S)-type in the presence of 4-chloromercuribenzoate
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
Clostridium acidi-urici
-
enzyme has acetyl-CoA enolase activity that is induced by 2-oxoglutarate and Co2+
-
r
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
Clostridium acidi-urici
-
stereospecific for (R)-citrates
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
-
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
-
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
-
-
-
-
r
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
-
stereospecific for (R)-citrates, no change from (R)-type to (S)-type in the presence of 4-chloromercuribenzoate
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
-
stereospecificity of citrate synthase in extracts can be changed reversibly from the (R)-type to the (S)-type by treatment with 4-chloromercuribenzoate
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
-
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
-
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
-
-
-
-
?
additional information
?
-
the protein does not have homocitrate synthase activity
-
-
?
additional information
?
-
the protein does not have homocitrate synthase activity
-
-
?
additional information
?
-
-
no activity with propionyl-CoA, 2-oxoglutarate, pyruvate, and 2-oxo-3-methylbutanoate
-
-
?
additional information
?
-
-
no activity with propionyl-CoA, 2-oxoglutarate, pyruvate, and 2-oxo-3-methylbutanoate
-
-
?
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4-hydroxymercuribenzoate
-
complete inhibition at 0.1 mM
5,5'-dithiobis-2-nitrobenzoate
-
30% inhibition at 10 mM
aerobic conditions
-
50% inactivation in 24 h by aerobic conditions
-
Cd2+
Clostridium acidi-urici
-
complete inactivation
H2O2
Clostridium acidi-urici
-
-
Hg2+
Clostridium acidi-urici
-
complete inactivation
iodoacetamide
Clostridium acidi-urici
-
strong inhibition
L-lysine
about 80% residual activity at 0.5 mM
p-chloromercuribenzoate
-
0.002 mM, inactivation
Zn2+
Clostridium acidi-urici
-
above 0.02 mM, activation below
2-oxoglutarate
Clostridium acidi-urici
-
5 mM, 64% inhibition, competitive vs. oxaloacetate
2-oxoglutarate
-
40% inhibition at 10 mM
4-chloromercuribenzoate
Clostridium acidi-urici
-
strong inhibition
4-chloromercuribenzoate
Clostridium acidi-urici
-
0.04 mM, 73% inhibition
4-chloromercuribenzoate
-
0.04 mM, 27% inhibition
4-chloromercuribenzoate
-
1 mM and 5 mM, 35 and 42% inhibition in extracts of Barker strain, respectively
ATP
about 40% residual activity at 5 mM
ATP
-
30% inhibition at 10 mM
citrate
about 40% residual activity at 10 mM
citrate
-
40% inhibition at 10 mM
EDTA
-
0.05 mM, complete inhibition, reactivation by addition of Mg2+, Mn2+, or Co2+
EDTA
-
complete inhibition at 0.2 mM
additional information
Clostridium acidi-urici
-
not inhibited by 5,5'-dithiobis(2-nitrobenzoate)
-
additional information
-
citrate synthase in extracts is not inhibited by EDTA
-
additional information
-
citrate synthase in extracts is not inhibited by EDTA
-
additional information
not influenced by 2-oxoglutarate
-
additional information
-
not inhibited by 5 mM NADH
-
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Gottschalk, G.
Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici
Eur. J. Biochem.
7
301-106
1969
Clostridium acidi-urici
brenda
Goschalk, G.; Dittbrenner, S.
Properties of (R)-citrate synthase from Clostridium acici-urici
Hoppe-Seyler's Z. Physiol. chem.
351
1183-1190
1970
Clostridium acidi-urici
-
brenda
Dittbrenner, S.; Chowdhury, A.A.; Gottschalk, G.
The stereospecificity of the (R)-citrate synthase in the presence of p-chloromercuribenzoate
Biochem. Biophys. Res. Commun.
36
802-808
1969
Clostridium acidi-urici, Clostridium kluyveri
brenda
Stern, J.R.; O'brien, R.W.
Failure of ethylenediaminetetraacetate or manganese to affect (R)-citrate synthesis in Clostridium kluyveri and Clostridium cylndrosporum
FEBS Lett.
4
72-74
1969
Clostridium cylindrosporum, Clostridium kluyveri
brenda
O'Brien, R.W.; Stern, J.R.
Reversal of the stereospecificity of the citrate synthase of Clostridium kluyveri by p-chloromercuribenzoate
Biochem. Biophys. Res. Commun.
34
271-276
1969
Clostridium kluyveri
brenda
Wunderwald, P.; Buckel, W.; Lenz, H.; Buschmeier, V.; Eggerer, H.; Gottschalk, G.; Cornforth, J.W.; Redmond, J.W.; Mallaby, R.
Stereochemistry of the re-citrate-synthase reaction
Eur. J. Biochem.
24
216-221
1971
Clostridium acidi-urici
brenda
Gottschalk, G.; Dittbrenner, S.; Lenz, H.; Eggerer, H.
re-Citrate synthase reaction
Eur. J. Biochem.
26
455-461
1972
Clostridium acidi-urici
brenda
Li, F.; Hagemeier, C.H.; Seedorf, H.; Gottschalk, G.; Thauer, R.K.
Re-citrate synthase from Clostridium kluyveri is phylogenetically related to homocitrate synthase and isopropylmalate synthase rather than to Si-citrate synthase
J. Bacteriol.
189
4299-4304
2007
Clostridium kluyveri, Desulfovibrio desulfuricans, Desulfovibrio vulgaris
brenda
Marco-Urrea, E.; Paul, S.; Khodaverdi, V.; Seifert, J.; von Bergen, M.; Kretzschmar, U.; Adrian, L.
Identification and characterization of a Re-citrate synthase in Dehalococcoides strain CBDB1
J. Bacteriol.
193
5171-5178
2011
Dehalococcoides sp. (P0DO96), Dehalococcoides sp. CBDB1 (P0DO96)
brenda
Kim, M.; Le, H.M.; Xie, X.; Feng, X.; Tang, Y.J.; Mouttaki, H.; McInerney, M.J.; Buckel, W.
Two pathways for glutamate biosynthesis in the syntrophic bacterium Syntrophus aciditrophicus
Appl. Environ. Microbiol.
81
8434-8444
2015
Syntrophus aciditrophicus
brenda
Kim, M.; Le, H.; McInerney, M.J.; Buckel, W.
Identification and characterization of re-citrate synthase in Syntrophus aciditrophicus
J. Bacteriol.
195
1689-1696
2013
Syntrophus aciditrophicus, Syntrophus aciditrophicus ATCC 700169
brenda
Xiong, W.; Lo, J.; Chou, K.; Wu, C.; Magnusson, L.; Dong, T.; Maness, P.
Isotope-assisted metabolite analysis sheds light on central carbon metabolism of a model cellulolytic bacterium Clostridium thermocellum
Front. Microbiol.
9
1947
2018
Acetivibrio thermocellus
brenda