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Disease on EC 2.3.2.B11 - ubiquitin transferase RING E3 (calmodulin-selective)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Lung Injury
TRIM21 mitigates human lung microvascular endothelial cells inflammatory responses to lipopolysaccharide.
Adenocarcinoma
Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells.
Adenoviridae Infections
E1B 55k-independent dissociation of the DNA ligase IV/XRCC4 complex by E4 34k during adenovirus infection.
Alzheimer Disease
Tau phosphorylation, molecular chaperones, and ubiquitin E3 ligase: clinical relevance in Alzheimer's disease.
Angelman Syndrome
Aberrant expression of genes necessary for neuronal development and notch signaling in an epileptic mind bomb zebrafish.
Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome.
Another patient with MECP2 mutation without classic Rett syndrome phenotype.
Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome.
Human disorders of ubiquitination and proteasomal degradation.
Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways.
Loss of nuclear UBE3A activity is the predominant cause of Angelman syndrome in individuals carrying UBE3A missense mutations.
Molecular Evolution, Neurodevelopmental Roles and Clinical Significance of HECT-Type UBE3 E3 Ubiquitin Ligases.
Potential therapeutic approaches for Angelman syndrome.
Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10.
UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity.
Arthritis, Rheumatoid
Association of Cullin1 haplotype variants with rheumatoid arthritis and response to methotrexate.
Ataxia
Biallelic mutations in RNF220 cause laminopathies featuring leukodystrophy, ataxia and deafness.
WWOX modulates the ATR-mediated DNA damage checkpoint response.
Atherosclerosis
Smooth muscle cell-specific knockout of FBW7 exacerbates intracranial atherosclerotic stenosis.
The Role of Ubiquitin E3 Ligase in Atherosclerosis.
The SCFFBXO3 ubiquitin E3 ligase regulates inflammation in atherosclerosis.
Autoimmune Diseases
TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.
Bacterial Infections
M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila.
Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity.
Breast Neoplasms
"DNA Binding Region" of BRCA1 Affects Genetic Stability through modulating the Intra-S-Phase Checkpoint.
Ca2+ -activated K+ channel KCa 1.1 as a therapeutic target to overcome chemoresistance in three-dimensional sarcoma spheroid models.
Cullin-3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2-positive breast cancer cells.
Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer.
Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer.
Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer.
Regulation of metformin response by breast cancer associated gene 2.
Role of the BCA2 ubiquitin E3 ligase in hormone responsive breast cancer.
The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway.
The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis.
The WWP1 ubiquitin E3 ligase increases TRAIL resistance in breast cancer.
Transcriptional activation of breast cancer-associated gene 2 by estrogen receptor.
Ubiquitin ligase CHIP suppresses cancer stem cell properties in a population of breast cancer cells.
Carcinogenesis
A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1.
F-box protein FBXL2 inhibits gastric cancer proliferation by ubiquitin-mediated degradation of forkhead box M1.
MKRN2 inhibits migration and invasion of non-small-cell lung cancer by negatively regulating the PI3K/Akt pathway.
Overexpression of the human ubiquitin E3 ligase CUL4A alleviates hypoxia-reoxygenation injury in pheochromocytoma (PC12) cells.
Parkinson's disease-associated protein Parkin: an unusual player in cancer.
Carcinoma
Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells.
Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell Renal Cell Carcinoma.
Carcinoma, Hepatocellular
ASB3 knockdown promotes mitochondrial apoptosis via activating the interdependent cleavage of Beclin1 and caspase-8 in hepatocellular carcinoma.
Carcinoma, Renal Cell
Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell Renal Cell Carcinoma.
Cardiomegaly
HECT (Homologous to the E6-AP Carboxyl Terminus)-Type Ubiquitin E3 Ligase ITCH Attenuates Cardiac Hypertrophy by Suppressing the Wnt/?-Catenin Signaling Pathway.
The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling.
Cardiomyopathies
Biallelic mutations in RNF220 cause laminopathies featuring leukodystrophy, ataxia and deafness.
Cardiotoxicity
HECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species-Induced Cardiotoxicity.
Cerebellar Ataxia
Identification of CHIP as a novel causative gene for autosomal recessive cerebellar ataxia.
Colitis
A20 Restores Impaired Intestinal Permeability and Inhibits Th2 Response in Mice with Colitis.
pVAX1-A20 alleviates colitis in mice by promoting regulatory T cells.
Regulation of anergy-related ubiquitin E3 ligase, GRAIL, in murine models of colitis and patients with Crohn's disease.
Colorectal Neoplasms
A Propensity Score-adjusted Analysis of the Effects of Ubiquitin E3 Ligase Copy Number Variation in Peripheral Blood Leukocytes on Colorectal Cancer Risk.
Impact of loss-of-function mutations at the RNF43 locus on colorectal cancer development and progression.
Crohn Disease
Regulation of anergy-related ubiquitin E3 ligase, GRAIL, in murine models of colitis and patients with Crohn's disease.
Cysts
Arabidopsis miR827 mediates post-transcriptional gene silencing of its ubiquitin E3 ligase target gene in the syncytium of the cyst nematode Heterodera schachtii to enhance susceptibility.
Deafness
Biallelic mutations in RNF220 cause laminopathies featuring leukodystrophy, ataxia and deafness.
Epilepsy
Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease.
Eye Abnormalities
Expanding the clinical and mutational spectrum of Kaufman oculocerebrofacial syndrome with biallelic UBE3B mutations.
Fanconi Anemia
Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation.
Generation of mouse FANCL antibody and analysis of FANCL protein expression profile in mouse tissues.
Germ-cell specific protein gametogenetin protein 2 (GGN2), expression in the testis, and association with intracellular membrane.
Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex.
The Fanconi anemia ubiquitin E3 ligase complex as an anti-cancer target.
Herpes Simplex
A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7.
Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells.
Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7.
Hyperalgesia
The ubiquitin E3 ligase Nedd4-2 relieves mechanical allodynia through the ubiquitination of TRPA1 channel in db/db mice.
Hypertension
Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.
Hypogonadism
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.
Infections
A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7.
Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.
JAK3 restrains inflammatory responses and protects against periodontal disease through Wnt3a signaling.
Stabilization of p53 in influenza A virus-infected cells is associated with compromised MDM2-mediated ubiquitination of p53.
Infertility, Male
Parkin blushed by PINK1.
Intellectual Disability
Expanding the clinical and mutational spectrum of Kaufman oculocerebrofacial syndrome with biallelic UBE3B mutations.
Kaufman oculo-cerebro-facial syndrome in a child with small and absent terminal phalanges and absent nails.
RNF220/ZC4H2-mediated monoubiquitination of Phox2 is required for noradrenergic neuron development.
The ubiquitin ligase UBE3B, disrupted in intellectual disability and absent speech, regulates metabolic pathways by targeting BCKDK.
Ischemic Stroke
The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic Stroke by Ubiquitinating and Activating Rac1.
Lafora Disease
Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease.
Latent Infection
Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells.
Liver Neoplasms
Ubiquitin E3 ligase SCF(?-TRCP) regulates TRIB2 stability in liver cancer cells.
Lung Injury
Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4.
Lung Neoplasms
Cigarette smoke suppresses the ubiquitin-dependent degradation of OLC1.
Covalent ISG15 conjugation to CHIP promotes its ubiquitin E3 ligase activity and inhibits lung cancer cell growth in response to type I interferon.
Lymphoma
c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-? type II receptor.
c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis.
LGR4: Not Just for Wnt Anymore?
Myostatin Induces Insulin Resistance via Casitas B-Lineage Lymphoma b (Cblb)-mediated Degradation of Insulin Receptor Substrate 1 (IRS1) Protein in Response to High Calorie Diet Intake.
TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation.
UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells.
Lymphoma, Mantle-Cell
UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells.
Measles
Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
Megalencephaly
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.
Melanoma
K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.
Mental Retardation, X-Linked
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.
Microcephaly
Kaufman oculo-cerebro-facial syndrome in a child with small and absent terminal phalanges and absent nails.
Multiple Myeloma
pSILAC method coupled with two complementary digestion approaches reveals PRPF39 as a new E7070-dependent DCAF15 substrate.
Muscle Hypotonia
Expanding the clinical and mutational spectrum of Kaufman oculocerebrofacial syndrome with biallelic UBE3B mutations.
Muscular Atrophy
Dynamic Changes to the Skeletal Muscle Proteome and Ubiquitinome Induced by the E3 Ligase, ASB2?.
Fbxw7? is an inducing mediator of dexamethasone-induced skeletal muscle atrophy in vivo with the axis of Fbxw7?-myogenin-atrogenes.
Identification of essential sequences for cellular localization in the muscle-specific ubiquitin E3 ligase MAFbx/Atrogin 1.
Sulforaphane prevents dexamethasone-induced muscle atrophy via regulation of the Akt/Foxo1 axis in C2C12 myotubes.
Targeting the Ubiquitin E3 Ligase MuRF1 to Inhibit Muscle Atrophy.
The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene.
Upregulation of ubiquitinated proteins and their degradation pathway in muscle atrophy induced by cisplatin in mice.
Muscular Dystrophies
TRIM32 ubiquitin E3 ligase, one enzyme for several pathologies: From muscular dystrophy to tumours.
Neoplasm Metastasis
Parkinson's disease-associated protein Parkin: an unusual player in cancer.
The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis.
Neoplasms
5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2.
A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor.
Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.
C-Cbl negatively regulates TRAF6-mediated NF-?B activation by promoting K48-linked polyubiquitination of TRAF6.
Clinicopathological significance of somatic RNF43 mutation and aberrant expression of ring finger protein 43 in intraductal papillary mucinous neoplasms of the pancreas.
CUL4B regulates cancer stem-like traits of prostate cancer cells by targeting BMI1 via miR200b/c.
Cullin 4-DCAF Proteins in Tumorigenesis.
Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway.
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination.
DTL promotes cancer progression by PDCD4 ubiquitin-dependent degradation.
Escape, or Vanish: Control the Fate of p53 through MDM2-Mediated Ubiquitination.
Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.
Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy.
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.
Inverse association between MDM2 and HUWE1 protein expression levels in human breast cancer and liposarcoma.
Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.
Loss of fragile X protein FMRP impairs homeostatic synaptic downscaling through tumor suppressor p53 and ubiquitin E3 ligase Nedd4-2.
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.
Mdm2 links genotoxic stress and metabolism to p53.
miR-335 Targets SIAH2 and Confers Sensitivity to Anti-Cancer Drugs by Increasing the Expression of HDAC3.
Mutations of c-Cbl in myeloid malignancies.
Pharmacological Activation of p53 during Human Monocyte to Macrophage Differentiation Attenuates Their Pro-Inflammatory Activation by TLR4, TLR7 and TLR8 Agonists.
Prolyl isomerase Pin1 in cancer.
pSILAC method coupled with two complementary digestion approaches reveals PRPF39 as a new E7070-dependent DCAF15 substrate.
RAB40C regulates RACK1 stability via the ubiquitin-proteasome system.
Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance.
Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms.
Solution structure of the C4 zinc finger domain of HDM2.
Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice.
Synthesis of androstanopyridine and pyrimidine compounds as novel activators of the tumor suppressor protein p53.
Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies.
Ternary complex formation of pVHL, elongin B and elongin C visualized in living cells by a fluorescence resonance energy transfer-fluorescence lifetime imaging microscopy technique.
The amplified WWP1 gene is a potential molecular target in breast cancer.
The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular Locations.
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity.
The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.
The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.
The ubiquitin E3 ligase activity of BRCA1 and its biological functions.
The ubiquitin E3 ligase Cbl-b in T cells tolerance and tumor immunity.
The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway.
The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling.
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.
The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis.
Transcriptional dysregulation of TRIM29 promotes colorectal cancer carcinogenesis via pyruvate kinase-mediated glucose metabolism.
TRIAD1 Is a Novel Transcriptional Target of p53 and Regulates Nutlin-3a-Induced Cell Death.
TRIM32 ubiquitin E3 ligase, one enzyme for several pathologies: From muscular dystrophy to tumours.
Ubiquitin E3 Ligase CRL4CDT2/DCAF2 as a Potential Chemotherapeutic Target for Ovarian Surface Epithelial Cancer.
Ubiquitin E3 ligase Itch negatively regulates osteoclast formation by promoting deubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6.
Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth.
Ubiquitin E3 Ligase Pellino-1 Inhibits IL-10-mediated M2c Polarization of Macrophages, Thereby Suppressing Tumor Growth.
Ubiquitin ligase CHIP suppresses cancer stem cell properties in a population of breast cancer cells.
Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2.
Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment.
Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons.
Nervous System Diseases
UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity.
Neuroblastoma
Using Chemistry to Target Neuroblastoma.
Neurodegenerative Diseases
Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome.
Salubrinal, ER stress inhibitor, attenuates kainic acid-induced hippocampal cell death.
Neuronal Ceroid-Lipofuscinoses
Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components.
Obesity, Abdominal
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.
Ovarian Neoplasms
Interaction of E3 Ubiquitin Ligase MARCH7 with Long Noncoding RNA MALAT1 and Autophagy-Related Protein ATG7 Promotes Autophagy and Invasion in Ovarian Cancer.
Parkinson Disease
An autopsy case of PARK2 due to a homozygous exon 2 deletion of parkin and associated with ?-synucleinopathy.
Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A.
Parkin Regulates the Activity of Pyruvate Kinase M2.
Parkin uses the UPS to ship off dysfunctional mitochondria.
Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.
PINK1 and Parkin: emerging themes in mitochondrial homeostasis.
S-Nitrosylation of Critical Protein Thiols Mediates Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases.
Spatiotemporally controlled initiation of Parkin-mediated mitophagy within single cells.
Sulfhydration mediates neuroprotective actions of parkin.
Targeting Skp1, an Ubiquitin E3 Ligase Component Found Decreased in Sporadic Parkinson's Disease.
The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease.
The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration.
Parkinsonian Disorders
Human disorders of ubiquitination and proteasomal degradation.
Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.
Overexpression of Nrdp1/FLRF sensitizes cells to oxidative stress.
Pheochromocytoma
Overexpression of the human ubiquitin E3 ligase CUL4A alleviates hypoxia-reoxygenation injury in pheochromocytoma (PC12) cells.
Pneumonia
The proinflammatory role of HECTD2 in innate immunity and experimental lung injury.
TRIM65 E3 ligase targets VCAM-1 degradation to limit LPS-induced lung inflammation.
Polycythemia
Human disorders of ubiquitination and proteasomal degradation.
Polyendocrinopathies, Autoimmune
Human disorders of ubiquitination and proteasomal degradation.
Prostatic Neoplasms
gp78 is specifically expressed in human prostate cancer rather than normal prostate tissue.
Increased acid ceramidase expression depends on upregulation of androgen-dependent deubiquitinases, USP2, in a human prostate cancer cell line, LNCaP.
JS-K, a nitric oxide pro-drug, regulates growth and apoptosis through the ubiquitin-proteasome pathway in prostate cancer cells.
Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer.
Pseudohypoaldosteronism
Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.
Pulmonary Disease, Chronic Obstructive
Mitochondrial alterations during oxidative stress in chronic obstructive pulmonary disease.
Rett Syndrome
Another patient with MECP2 mutation without classic Rett syndrome phenotype.
Scleroderma, Systemic
Kelch-like protein 42 is a pro-fibrotic ubiquitin E3 ligase involved in in systemic sclerosis.
Seizures
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.
Spinocerebellar Ataxias
In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins.
Starvation
Regulatory factors controlling muscle mass: Competition between innate immune function and anabolic signals in regulation of atrogin-1 in Atlantic salmon.
Stomach Neoplasms
c-FLIP is a target of the E3 ligase deltex1 in gastric cancer.
Lycorine hydrochloride inhibits cell proliferation and induces apoptosis through promoting FBXW7-MCL1 axis in gastric cancer.
Never-in-mitosis A-related kinase 8, a novel target of von-Hippel-Lindau tumor suppressor protein, promotes gastric cancer cell proliferation.
Talipes Cavus
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.
Tremor
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.
ubiquitin transferase ring e3 (calmodulin-selective) deficiency
Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome.
Uterine Cervical Neoplasms
Ubiquitin E3 Ligase MARCH7 promotes proliferation and invasion of cervical cancer cells through VAV2-RAC1-CDC42 pathway.
Vascular Malformations
Clinicopathological and Genomic Characterization of a Simmental Calf with Generalized Bovine Juvenile Angiomatosis.
Virus Diseases
The ORF3 protein of porcine circovirus type 2 interacts with porcine ubiquitin E3 ligase Pirh2 and facilitates p53 expression in viral infection.
von Hippel-Lindau Disease
Human disorders of ubiquitination and proteasomal degradation.