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Information on EC 2.3.2.36 - RING-type E3 ubiquitin transferase (cysteine targeting)

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EC Tree
IUBMB Comments
This relatively rare subpopulation of RING-type E3 ubiquitin transferases (cf. EC 2.3.2.27), found in mammals and herpes viruses, can transfer ubiquitin to a cysteine residue in target proteins. Additional ubiquitin molecules are polymerized on top of the initial ubiquitin molecule by formation of an isopeptide linkage with lysine48 in the pre-attached ubiquitin .
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Word Map
  • 2.3.2.36
  • monoubiquitination
  • nedd8
  • ccr4-not
  • neddylation
  • cereblon
The enzyme appears in viruses and cellular organisms
Reaction Schemes
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-cysteine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-S-ubiquitinyl-L-cysteine
Synonyms
ring e3 ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine
show the reaction diagram
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