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(11Z)-eicosenoyl-CoA + malonyl-CoA
?
-
-
-
-
?
(9Z)-hexadec-9-enoyl-CoA + malonyl-CoA
(11Z)-3-oxooctadec-11-enoyl-CoA + CO2 + coenzyme A
(9Z,12Z)-octadec-9,12-dienoyl-CoA + malonyl-CoA
(11Z,14Z)-3-oxoeicosa-11,14-dienoyl-CoA + CO2 + coenzyme A
(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl-CoA + malonyl-CoA
(11Z,14Z,17Z)-3-oxoeicosa-11,14,17-trienoyl-CoA + CO2 + coenzyme A
a very-long-chain acyl-CoA + malonyl-CoA
a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
a very-long-chain acyl-CoA + malonyl-CoA
a very-long-chain 3-oxoacyl-CoA + CO2 + coenzyme A
-
-
-
?
arachidoyl-CoA + malonyl-CoA
?
behenoyl-CoA + malonyl-CoA
?
cerotoyl-CoA + malonyl-CoA
?
decanoyl-CoA + malonyl-CoA
?
-
-
-
-
?
eicosenoyl-CoA + malonyl-CoA
?
22:1DELTA13
-
-
?
erucoyl-CoA + malonyl-CoA
?
lauroyl-CoA + malonyl-CoA
?
-
-
-
-
?
myristoyl-CoA + malonyl-CoA
?
-
best substrate
-
-
?
n-hexacosanoyl-CoA + malonyl-CoA
?
-
-
-
?
octanoyl-CoA + malonyl-CoA
?
-
-
-
-
?
oleoyl-CoA + malonyl-CoA
?
-
in contrast to stearic acid-CoA, oleic acid-CoA serves as a less suitable substrate for elongation
-
-
?
oleoyl-CoA + malonyl-CoA
CoA + 3-oxo-eicosenoyl-CoA + 3-oxo-erucoyl-CoA + CO2
-
preferred substrate
3-oxo-eicosenoyl-CoA is the major product
-
?
palmitoleoyl-CoA + malonyl-CoA
?
-
-
-
-
?
palmitoyl-CoA + malonyl-CoA
3-oxostearoyl-CoA + CO2 + CoA
-
-
-
?
palmitoyl-CoA + malonyl-CoA
?
stearoyl-CoA + malonyl-CoA
?
stearoyl-CoA + malonyl-CoA
CoA + 3-oxo-eicosanoyl-CoA + CO2
-
-
major product
-
?
very-long-chain acyl-CoA + malonyl-CoA
CoA + very-long-chain 3-oxoacyl-CoA + CO2
additional information
?
-
(9Z)-hexadec-9-enoyl-CoA + malonyl-CoA
(11Z)-3-oxooctadec-11-enoyl-CoA + CO2 + coenzyme A
-
-
-
ir
(9Z)-hexadec-9-enoyl-CoA + malonyl-CoA
(11Z)-3-oxooctadec-11-enoyl-CoA + CO2 + coenzyme A
-
-
-
ir
(9Z,12Z)-octadec-9,12-dienoyl-CoA + malonyl-CoA
(11Z,14Z)-3-oxoeicosa-11,14-dienoyl-CoA + CO2 + coenzyme A
-
-
-
ir
(9Z,12Z)-octadec-9,12-dienoyl-CoA + malonyl-CoA
(11Z,14Z)-3-oxoeicosa-11,14-dienoyl-CoA + CO2 + coenzyme A
-
-
-
ir
(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl-CoA + malonyl-CoA
(11Z,14Z,17Z)-3-oxoeicosa-11,14,17-trienoyl-CoA + CO2 + coenzyme A
-
-
-
?
(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl-CoA + malonyl-CoA
(11Z,14Z,17Z)-3-oxoeicosa-11,14,17-trienoyl-CoA + CO2 + coenzyme A
-
-
-
?
a very-long-chain acyl-CoA + malonyl-CoA
a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
-
-
-
-
?
a very-long-chain acyl-CoA + malonyl-CoA
a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
-
-
-
?
arachidoyl-CoA + malonyl-CoA
?
-
-
-
-
?
arachidoyl-CoA + malonyl-CoA
?
-
25% activity compared to oleoyl-CoA
-
-
?
arachidoyl-CoA + malonyl-CoA
?
-
best substrate for At4g34510
-
-
?
arachidoyl-CoA + malonyl-CoA
?
-
-
-
-
?
behenoyl-CoA + malonyl-CoA
?
-
-
-
-
?
behenoyl-CoA + malonyl-CoA
?
-
-
-
-
?
cerotoyl-CoA + malonyl-CoA
?
-
-
-
-
?
cerotoyl-CoA + malonyl-CoA
?
-
-
-
-
?
erucoyl-CoA + malonyl-CoA
?
-
22:1DELTA13
-
-
?
erucoyl-CoA + malonyl-CoA
?
20:1DELTA11
-
-
?
palmitoyl-CoA + malonyl-CoA
?
-
-
-
-
?
palmitoyl-CoA + malonyl-CoA
?
-
best substrate for KCS1
-
-
?
palmitoyl-CoA + malonyl-CoA
?
-
-
-
-
?
stearoyl-CoA + malonyl-CoA
?
-
-
-
-
?
stearoyl-CoA + malonyl-CoA
?
-
best substrate for At2g26640 and FAE1
-
-
?
very-long-chain acyl-CoA + malonyl-CoA
CoA + very-long-chain 3-oxoacyl-CoA + CO2
-
-
-
-
?
very-long-chain acyl-CoA + malonyl-CoA
CoA + very-long-chain 3-oxoacyl-CoA + CO2
-
-
-
-
?
very-long-chain acyl-CoA + malonyl-CoA
CoA + very-long-chain 3-oxoacyl-CoA + CO2
-
-
-
-
?
very-long-chain acyl-CoA + malonyl-CoA
CoA + very-long-chain 3-oxoacyl-CoA + CO2
-
-
-
-
?
additional information
?
-
-
At1g01120 (KCS1) and At2g26640 have broad substrate specificities when assayed with saturated and monounsaturated C16 to C24 acyl-CoAs while At4g34510 is specific for saturated fatty acyl-CoA substrates. KCS1 is most active with palmitic acid, palmitoleic acid, stearic acid, and arachidic acid but has very little activity with oleic acid and acyl chains longer than C20. At4g34510 is specific for saturated acyl-CoAs up to C22. FAE1 uses palmitic acid, palmitoleic acid, stearic acid, oleic acid, arachidic acid, 20:1, behenic acid, erucic acid, and lignoceric acid as substratesis and is specific for acyl-CoAs of 16 and 18 carbons in length
-
-
?
additional information
?
-
-
the enzyme shows highest activity towards saturated and monounsaturated C16 and C18. In the absence of an acyl-CoA substrate, the enzyme is unable to carry out decarboxylation of malonyl-CoA
-
-
?
additional information
?
-
-
the enzyme shows no activity with polyunsaturated linoleic acid and alpha-linolenic acid and little or no activity with acyl-CoAs having 22 carbons or longer in chain length
-
-
?
additional information
?
-
the effect of CER2-LIKE1 and CER2-LIKE2 proteins on fatty acid elongation is limited to specific condensing enzyme partners, and CER2-LIKE proteins either have their own unique substrate specificity, or a unique effect on the substrate specificity of the condensing enzyme with which they function
-
-
?
additional information
?
-
the effect of CER2-LIKE1 and CER2-LIKE2 proteins on fatty acid elongation is limited to specific condensing enzyme partners, and CER2-LIKE proteins either have their own unique substrate specificity, or a unique effect on the substrate specificity of the condensing enzyme with which they function
-
-
?
additional information
?
-
almost no activity with palmitic acid and 17:1DELTA9
-
-
?
additional information
?
-
-
almost no activity with palmitic acid and 17:1DELTA9
-
-
?
additional information
?
-
almost no activity with palmitic acid and 17:1DELTA9
-
-
?
additional information
?
-
the enzyme is able to elongate the C16-acyl-CoA up to C26-acyl-CoA
-
-
?
additional information
?
-
-
the enzyme is able to elongate the C16-acyl-CoA up to C26-acyl-CoA
-
-
?
additional information
?
-
no activity with saturated and unsaturated fatty acids longer than C16
-
-
?
additional information
?
-
-
the enzyme is specific for acyl chain lengths between 16 and 20 carbons
-
-
-
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Acanthosis Nigricans
De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy.
Adrenoleukodystrophy
Bezafibrate for x-linked adrenoleukodystrophy.
Adrenoleukodystrophy
Enzymatic characterization of ELOVL1, a key enzyme in very long-chain fatty acid synthesis.
Adrenoleukodystrophy
The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy.
Breast Neoplasms
Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ER? in Breast Cancer Cells.
Breast Neoplasms
Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression.
Corneal Opacity
Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice.
Deafness
De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy.
Deafness
Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1.
Demyelinating Diseases
Dicer ablation in oligodendrocytes provokes neuronal impairment in mice.
Dermatitis
IFN-? Reduces Epidermal Barrier Function by Affecting Fatty Acid Composition of Ceramide in a Mouse Atopic Dermatitis Model.
Dry Eye Syndromes
Improvement of Evaporative Dry Eye With Meibomian Gland Dysfunction in Model Mice by Treatment With Ophthalmic Solution Containing Mineral Oil.
Dry Eye Syndromes
Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice.
Fatty Liver
Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice.
Fatty Liver
Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
Hyperglycemia
Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration.
Hyperkeratosis, Epidermolytic
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Ichthyosis
De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy.
Ichthyosis
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Ichthyosis
Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1.
Infections
Fatty Acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication.
Infections
Weighted Gene Co-Expression Network Analysis Identifies Key Modules and Hub Genes Associated with Mycobacterial Infection of Human Macrophages.
Insulin Resistance
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Insulin Resistance
Dysregulation of microRNA-125a contributes to obesity-associated insulin resistance and dysregulates lipid metabolism in mice.
Insulin Resistance
Macrophage elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Insulin Resistance
Mouse Elovl-6 promoter is an SREBP target.
Insulin Resistance
Role of fatty acid elongase Elovl6 in the regulation of energy metabolism and pathophysiological significance in diabetes.
Macular Degeneration
Loss of ER retention and sequestration of the wild-type ELOVL4 by Stargardt disease dominant negative mutants.
Multiple Myeloma
The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma.
Multiple System Atrophy
Analysis of GWAS-linked variants in multiple system atrophy.
Multiple System Atrophy
Investigating ELOVL7 coding variants in multiple system atrophy.
Neoplasms
Differences in elongation of very long chain fatty acids and fatty acid metabolism between triple-negative and hormone receptor-positive breast cancer.
Neoplasms
Identification of hub genes and key pathways associated with the progression of gynecological cancer.
Neoplasms
Novel Lipogenic Enzyme ELOVL7 Is Involved in Prostate Cancer Growth through Saturated Long-Chain Fatty Acid Metabolism.
Neoplasms
Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer.
Neoplasms
Signatures of Adverse Pathological Features, Androgen Insensitivity and Metastatic Potential in Prostate Cancer.
Neoplasms
Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells.
Neurocutaneous Syndromes
Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1.
Non-alcoholic Fatty Liver Disease
The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis.
Obesity
Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity.
Obesity
Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice.
Obesity
Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.
Optic Atrophy
De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy.
Paraplegia
De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy.
Paraplegia
Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1.
Parkinson Disease
Association of GALC, ZNF184, IL1R2 and ELOVL7 With Parkinson's Disease in Southern Chinese.
Parkinson Disease
Transcriptomic signatures of brain regional vulnerability to Parkinson's disease.
Prostatic Neoplasms
ELOVL5 is a critical and targetable fatty acid elongase in prostate cancer.
Prostatic Neoplasms
Novel Lipogenic Enzyme ELOVL7 Is Involved in Prostate Cancer Growth through Saturated Long-Chain Fatty Acid Metabolism.
Prostatic Neoplasms
The chromatin remodeling protein BRG1 links ELOVL3 trans-activation to prostate cancer metastasis.
Protein Deficiency
Enzymatic characterization of ELOVL1, a key enzyme in very long-chain fatty acid synthesis.
Rubella
Regulation of FATTY ACID ELONGATION1 expression and production in Brassica oleracea and Capsella rubella.
Starvation
Identification of a ?6 fatty acid elongase gene for arachidonic acid biosynthesis localized to the endoplasmic reticulum in the green microalga Myrmecia incisa Reisigl.
very-long-chain 3-oxoacyl-coa synthase deficiency
Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1.
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malfunction
-
complete loss of isoform KCS20 and KCS2 genes decreases the total wax content in stems and leaves by 20% and 15%, respectively. Kcs20 kcs2/daisy-1 double mutants exhibit significant reduction of C22 and C24 very-long-chain fatty acid derivatives but accumulation of C20 very-long-chain fatty acid derivatives in aliphatic suberin
malfunction
-
complete loss of KCS1 expression results in decreases of up to 80% in the levels of C26 to C30 wax alcohols and aldehydes, while smaller effects are observed on the major wax components, i.e. the C29 alkanes and C29 ketones on leaves, stems and siliques. The loss of KCS1 expression does not result in complete loss of any individual wax component or significantly decrease the total wax load
malfunction
-
FAE1 misexpression plants are similar to the wild type but display an essentially glabrous phenotype, owing to the selective death of trichome cells. Nuclei of arrested trichome cells in FAE1 misexpression plants cell-autonomously accumulate high levels of DNA damage, including double-strand breaks characteristic of lipoapoptosis
malfunction
-
null mutations in ELO3 result in accumulation of labeled precursors into inositol phosphoceramide, with little labeling in the more complex mannosylated sphingolipids, whereas disruption of ELO2 results in reduced levels of all sphingolipids. Mutations in ELO3 lead to elevated levels of C20 and C22 fatty acids (most abundant species is behenic acid which averages 3.1% of the total fatty acyl mass, a 10fold increase over wild type levels). ELO3 disruption results in an approximate 20% increase in the total levels of very long chain species. Sharply reduced levels of cerotic acid (approximately 20% wild type levels) and hydroxy-cerotic acid (approximately 40% of wild type levels) are found in an elo2 mutant strain
malfunction
-
suppression of CUT1 in transgenic Arabidopsis plants results in waxless (eceriferum) stems and siliques as well as conditional male sterility. In CUT1-suppressed plants, the C24 chain-length wax components predominate. Both decarbonylation and acyl reduction pathways are down-regulated in cut1-suppressed plants
malfunction
-
enzyme mutations reduce the amount of wax, but not the total load of cutin in leaf blades, and result in an increased rate of water loss. Enzyme defects affect cuticle structure, water barrier properties of the cuticle and infection by the powdery mildew fungus
metabolism
the enzyme is involved in the fatty acid elongation cycle consisting of the reaction steps of condensation, reduction, dehydration, and reduction
metabolism
the enzyme is involved in docosahexaenoic acid synthesis pathway in the teleost Solea senegalensis
metabolism
the enzyme is involved in very-long-chain fatty acid elongation beyond C22. Elongation beyond C24 requires the participation of CER2
physiological function
a MALCE1 gene-silenced strain exhibits a low content of octadecanoic acid and a high content of hexadecanoic acid
physiological function
-
Elo2p is involved in the elongation of fatty acids up to 24 carbons and has the highest affinity for substrates with chain lengths less than 22 carbons. Elo3p has a broader substrate specificity and is essential for the conversion of 24-carbon acids to 26-carbon species
physiological function
-
enzymic activity of FAE1 is required to suppress trichome development. The enzyme plays a role in the biosynthesis of cutin
physiological function
-
FAE1 is the rate-limiting enzyme for very-long-chain fatty acid biosynthesis in Arabidopsis seed
physiological function
-
isoforms KCS20 and KCS2/DAISY are functionally redundant in the two-carbon elongation to C22 very-long-chain fatty acid that is required for cuticular wax and root suberin biosynthesis
physiological function
-
the CUT1 enzyme is required for cuticular wax biosynthesis and pollen fertility
physiological function
the enzyme has strong capability for improving the erucic acid content
physiological function
-
the enzyme is required for epicuticular wax in bolting stems
physiological function
the enzyme plays a role in the production of epicuticular and pollen coat lipids more than 28 carbons long
physiological function
-
the enzyme plays a role in wax biosynthesis and is involved in both, the decarbonylation and acyl-reduction wax synthesis pathways
physiological function
3-ketoacyl-CoA reductase, KAR, regulates enzyme ELOVL6 via two modes: in the first mode, KAR may induce conformational changes in ELOVL6 to become a structure that can undergo catalysis. In the second mode, conversion of 3-oxoacyl-CoA to 3-hydroxyacyl-CoA by KAR may facilitate release of the product from the presumed ELOVL6-KAR complex
physiological function
-
elongase Onion2 mutants produce very small shoots in which leaves are fused to each other, and cease growing after germination. The midrib of Onion2 mutant leaf blades is not developed correctly. The amount of saturated very-long-chain fatty acids of C = 20, 24, 26, 28 and 30 is reduced in the mutant shoots
physiological function
-
Elovl1 knockout mice die shortly after birth due to epidermal barrier defects. The lipid lamellae in the stratum corneum are largely diminished in these mice. In the epidermis of the Elovl1-null mice, the levels of Cers with more than C26 fatty acids are decreased, while those of Cers with less than C24 fatty acids are increased. The levels of C24 sphingomyelin are reduced, accompanied by an increase in C20 sphingomyelin levels. Ceramide synthases, CerS2 and CerS3, expressed in an epidermal layer-specific manner, regulate Elovl1 to produce acyl coenzyme As with different chain lengths
physiological function
in rice lines in which the gene encoding a fatty acid elongase, CUT1L, is silenced, both 1-aminocyclopropane-1-carboxylic acid synthase ACS1 expression and aerenchyma formation are reduced. The expression of ACS1, CUT1L, and ATP-binding cassette transporter RCN1/OsABCG5 is induced predominantly in the outer part of roots under stagnant conditions. In rice under oxygen-deficient conditions, very-long-chain fatty acids increase ethylene production by promoting 1-aminocyclopropane-1-carboxylic acid biosynthesis in the outer part of roots, which, in turn, induces aerenchyma formation in the root cortex
physiological function
rosette leafs of CER2-LIKE1 mutant plants show increased levels of C30-derived waxes and less C32-derived C31 alkane. Transferase CER2 and CER2-LIKE1-1 have redundant functions in elongation past C28 in leaves. CER2-LIKE1 partially rescues the stem wax-deficient phenotype of cer2-5. Yeast cells coexpressing condensing enzyme CER6 and CER2-LIKE1 synthesize C28, C30, C32, and C34 very-long-chain fatty acids
physiological function
transferase CER2 and CER2-LIKE2 have semiredundant functions required for male fertility
physiological function
enzyme overexpression increases the cuticular wax load and the quantity of C30-C34 fatty acids in rice leaves. The enzyme is involved in reproductive and vegetative organ development processes as well as epicuticular wax formation in rice
physiological function
-
a MALCE1 gene-silenced strain exhibits a low content of octadecanoic acid and a high content of hexadecanoic acid
-
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Dittrich, F.; Zajonc, D.; Huhne, K.; Hoja, U.; Ekici, A.; Greiner, E.; Klein, H.; Hofmann, J.; Bessoule, J.J.; Sperling, P.; Schweizer, E.
Fatty acid elongation in yeast. Biochemical characteristics of the enzyme system and isolation of elongation-defective mutants
Eur. J. Biochem.
252
477-485
1998
Saccharomyces cerevisiae, Saccharomyces cerevisiae X2180-1A
brenda
Blacklock, B.J.; Kelley, D.; Patel, S.
A fatty acid elongase ELO with novel activity from Dictyostelium discoideum
Biochem. Biophys. Res. Commun.
374
226-230
2008
Dictyostelium discoideum (Q54CJ4), Dictyostelium discoideum, Dictyostelium discoideum AX3 (Q54CJ4)
brenda
Sakuradani, E.; Nojiri, M.; Suzuki, H.; Shimizu, S.
Identification of a novel fatty acid elongase with a wide substrate specificity from arachidonic acid-producing fungus Mortierella alpina 1S-4
Appl. Microbiol. Biotechnol.
84
709-716
2009
Mortierella alpina (C8KHM6), Mortierella alpina, Mortierella alpina 1S-4 (C8KHM6), Mortierella alpina 1S-4
brenda
Fujisawa, M.; Watanabe, M.; Choi, S.K.; Teramoto, M.; Ohyama, K.; Misawa, N.
Enrichment of carotenoids in flaxseed (Linum usitatissimum) by metabolic engineering with introduction of bacterial phytoene synthase gene crtB
J. Biosci. Bioeng.
105
636-641
2008
Crambe hispanica subsp. abyssinica (Q32VC2)
brenda
Blacklock, B.; Jaworski, J.
Substrate specificity of Arabidopsis 3-ketoacyl-CoA synthases
Biochem. Biophys. Res. Commun.
346
583-590
2006
Arabidopsis thaliana
brenda
Kunst, L.; Clemens, S.; Hooker, T.
Expression of the wax-specific condensing enzyme CUT1 in Arabidopsis
Biochem. Soc. Trans.
28
651-654
2000
Arabidopsis thaliana
brenda
Ghanevati, M.; Jaworski, J.
Engineering and mechanistic studies of the Arabidopsis FAE1 beta-ketoacyl-CoA synthase, FAE1 KCS
Eur. J. Biochem.
269
3531-3539
2002
Arabidopsis thaliana
brenda
Katavic, V.; Barton, D.; Giblin, E.; Reed, D.; Kumar, A.; Taylor, D.
Gaining insight into the role of serine 282 in B. napus FAE1 condensing enzyme
FEBS Lett.
562
118-124
2004
Brassica napus
brenda
Toke, D.; Martin, C.
Isolation and characterization of a gene affecting fatty acid elongation in Saccharomyces cerevisiae
J. Biol. Chem.
271
18413-18422
1996
Saccharomyces cerevisiae, Saccharomyces cerevisiae W3031B
brenda
Oh, C.; Toke, D.; Mandala, S.; Martin, C.
ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation
J. Biol. Chem.
272
17376-17384
1997
Saccharomyces cerevisiae
brenda
Qin, Y.; Pujol, F.; Hu, C.; Feng, J.; Kastaniotis, A.; Hiltunen, J.; Zhu, Y.
Genetic and biochemical studies in yeast reveal that the cotton fibre-specific GhCER6 gene functions in fatty acid elongation
J. Exp. Bot.
58
473-481
2007
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Arabidopsis thaliana
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Arabidopsis thaliana (Q9XF43)
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Arabidopsis thaliana
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Homo sapiens (Q9H5J4)
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Solea senegalensis (G8IIS1)
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Oryza sativa Japonica Group (Q10PV5)
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