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IUBMB CommentsInvolved in the synthesis of aerobactin from lysine in a strain of Escherichia coli.
The enzyme appears in viruses and cellular organisms
Synonyms
acetyltransferase, nepsilon-hydroxylysine, nepsilon-hydroxylysine acetylase, nepsilon-hydroxylysine:acetyl CoA nepsilon-transacetylase,
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acetyltransferase, nepsilon-hydroxylysine
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nepsilon-hydroxylysine acetylase
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nepsilon-hydroxylysine:acetyl CoA nepsilon-transacetylase
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acetyl-CoA + N6-hydroxy-L-lysine = CoA + N6-acetyl-N6-hydroxy-L-lysine
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Acyl group transfer
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acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase
Involved in the synthesis of aerobactin from lysine in a strain of Escherichia coli.
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acetyl-CoA + (5-hydroxyamine)pentan-1-amine
CoA + N-(5-aminopentyl)-N-hydroxyacetamide
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acetyl-CoA + DL-N6-hydroxylysine
CoA + N6-acetyl-N6-hydroxylysine
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acetyl-CoA + hydroxylamine
CoA + N-acetylhydroxylamine
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acetyl-CoA + L-N5-hydroxyornithine
CoA + N5-acetyl-N5-hydroxyornithine
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acetyl-CoA + L-N6-hydroxylysine
CoA + N6-acetyl-N6-hydroxylysine
acetyl-CoA + N-methylhydroxylamine
CoA + N-acetyl-N-methylhydroxylamine
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acetyl-CoA + N5-hydroxyornithine
CoA + N5-acetyl-N5-hydroxyornithine
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r
additional information
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acetyl-CoA + L-N6-hydroxylysine
CoA + N6-acetyl-N6-hydroxylysine
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acetyl-CoA + L-N6-hydroxylysine
CoA + N6-acetyl-N6-hydroxylysine
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preferred substrate
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additional information
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propionyl-CoA has 5% of activity compared to acetyl-CoA
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additional information
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enzyme is involved in the biosynthesis of aerobactin in E. coli
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acetyl-CoA + L-N6-hydroxylysine
CoA + N6-acetyl-N6-hydroxylysine
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additional information
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enzyme is involved in the biosynthesis of aerobactin in E. coli
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Coomassie brilliant blue
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mixed inhibitor
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0.33
1-amino-5-(hydroxyamino)pentane
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0.317
L-N5-hydroxyornithine
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0.055
L-N6-hydroxylysine
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0.396
N-Methylhydroxylamine
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0.043
acetyl-CoA
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+ L-N6-hydroxylysine
0.079
acetyl-CoA
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+ L-N5-hydroxyornithine
0.099
acetyl-CoA
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+ 1-amino-5-(hydroxyamino)pentane
0.101
acetyl-CoA
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+ N-methylhydroxylamine
1.81
acetyl-CoA
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+ hydroxylamine
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0.0000797
1-amino-5(hydroxyamino)pentane
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0.00177
hydroxylamine
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0.0000385
N-Methylhydroxylamine
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0.000112
N5-hydroxyornithine
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0.0000477
N6-hydroxylysine
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0.00071
Coomassie brilliant blue
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294, with plasmid pABN11
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150000 - 200000
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gel filtration, native enzyme
33000
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SDS-PAGE, calculated from DNA sequence
33000
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x * 33000, SDS-PAGE
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20°C, stable for several days
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4°C, stable for several months
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Coy, M.; Paw, B.H.; Bindereif, A.; Neilands, J.B.
Isolation and properties of N epsilon-hydroxylysine:acetyl coenzyme A nepsilon-transacetylase from Escherichia coli pABN11
Biochemistry
25
2485-2489
1986
Escherichia coli
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Lorenzo de, V.; Bindereif, A.; Paw, B.H.; Neilands, J.B.
Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12
J. Bacteriol.
165
570-578
1986
Escherichia coli
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