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IUBMB CommentsThe enzyme catalyses the transfer of a carboxyl group carried on a biotinylated biotin carboxyl carrier protein (BCCP) to acetyl-CoA, forming malonyl-CoA. In some organisms this activity is part of a multi-domain polypeptide that includes the carrier protein and EC 6.3.4.14, biotin carboxylase (see EC 6.4.1.2, acetyl-CoA carboxylase). Some enzymes can also carboxylate propanonyl-CoA and butanoyl-CoA (cf. EC 6.4.1.3, propionyl-CoA carboxylase).
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Acetyl CoA carboxylase
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acetyl-CoA carboxylase carboxyltransferase domain
CT-alphabeta subcomplex
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ACC
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ACCase
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accD5
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gene name, encoding a functional acetyl-CoA carboxylase subunit
accD5
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gene name, encoding a functional acetyl-CoA carboxylase subunit
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accD6
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gene name, encoding a functional acetyl-CoA carboxylase subunit
accD6
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gene name, encoding a functional acetyl-CoA carboxylase subunit
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accD6
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gene name, encoding a functional acetyl-CoA carboxylase subunit
accD6
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gene name, encoding a functional acetyl-CoA carboxylase subunit
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acetyl-CoA carboxylase
the enzyme consists of four catalytic subunits: biotin carboxylase, carboxyltransferase-alpha, carboxyltransferase-beta, and biotin carboxyl carrier protein
acetyl-CoA carboxylase
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acetyl-CoA carboxylase
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the enzyme consists of a biotin carboxylase activity, a biotin carboxyl carrier protein, and a carboxyltransferase activity
acetyl-CoA carboxylase
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the enzyme is composed of three proteins: biotin carboxylase, a biotin carboxyl carrier protein, and carboxyltransferase
acetyl-CoA carboxylase
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acetyl-CoA carboxylase
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acetyl-CoA carboxylase
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acetyl-CoA carboxylase
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acetyl-CoA carboxylase
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acetyl-CoA carboxylase
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acetyl-CoA carboxylase carboxyltransferase domain
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acetyl-CoA carboxylase carboxyltransferase domain
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carboxyltransferase
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carboxyltransferase
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component of acetyl-CoA carboxylase
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[biotin carboxyl-carrier protein 87]-N6-biotinyl-L-lysine + malonyl-CoA
[biotin carboxyl-carrier protein 87]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
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[biotin carboxyl-carrier protein 87]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein 87]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
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(3S)-beta-phenylalanine-L-valine-(4S)-methyl-2,5-pyrrolidinedione
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(3S)-L-valine-(4S)-methyl-2,5-pyrrolidinedione
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(3S)-methyl-2,5-pyrrolidinedione
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled soraphen A
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malonyl-CoA
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product inhibition
oleic acid
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irreversible enzyme inhibition
palmitoyl-acyl carrier protein
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allosteric, time-dependent, competitive inhibition
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pantothenic acid
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potent inhibitor
Tween 80
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reversible enzyme inhibition at 10 mM
additional information
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incorporation of biotin attachment domain-containing proteins (inactive analogs of biotin carboxyl transfer proteins that lack biotin) into the enzyme down-regulates its activity by displacing active (biotin-containing) biotin carboxyltransferase protein subunits
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Tuberculosis
AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strain.
Tuberculosis
AccD6, a member of the Fas II locus, is a functional carboxyltransferase subunit of the acyl-coenzyme A carboxylase in Mycobacterium tuberculosis.
Tuberculosis
Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis.
Tuberculosis
Pleiotropic effect of AccD5 and AccE5 depletion in acyl-coenzyme A carboxylase activity and in lipid biosynthesis in mycobacteria.
Tuberculosis
Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis.
Tuberculosis
Structure, activity, and inhibition of the Carboxyltransferase ?-subunit of acetyl coenzyme A carboxylase (AccD6) from Mycobacterium tuberculosis.
Tuberculosis
Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis.
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Evans, A.; Ribble, W.; Schexnaydre, E.; Waldrop, G.L.
Acetyl-CoA carboxylase from Escherichia coli exhibits a pronounced hysteresis when inhibited by palmitoyl-acyl carrier protein
Arch. Biochem. Biophys.
636
100-109
2017
Escherichia coli
brenda
Bilder, P.; Lightle, S.; Bainbridge, G.; Ohren, J.; Finzel, B.; Sun, F.; Holley, S.; Al-Kassim, L.; Spessard, C.; Melnick, M.; Newcomer, M.; Waldrop, G.
The structure of the carboxyltransferase component of acetyl-CoA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme
Biochemistry
45
1712-1722
2006
Staphylococcus aureus, Escherichia coli (P0ABD5)
brenda
Broussard, T.C.; Pakhomova, S.; Neau, D.B.; Bonnot, R.; Waldrop, G.L.
Structural analysis of substrate, reaction intermediate, and product binding in Haemophilus influenzae biotin carboxylase
Biochemistry
54
3860-3870
2015
Haemophilus influenzae
brenda
Raymer, B.; Kavana, M.; Price, A.; Wang, B.; Corcoran, L.; Kulathila, R.; Groarke, J.; Mann, T.
Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase
Bioorg. Med. Chem. Lett.
19
2804-2807
2009
Homo sapiens
brenda
Blanchard, C.; Chapman-Smith, A.; Wallace, J.; Waldrop, G.
The biotin domain peptide from the biotin carboxyl carrier protein of Escherichia coli acetyl-CoA carboxylase causes a marked increase in the catalytic efficiency of biotin carboxylase and carboxyltransferase relative to free biotin
J. Biol. Chem.
274
31767-31769
1999
Escherichia coli
brenda
Silvers, M.A.; Pakhomova, S.; Neau, D.B.; Silvers, W.C.; Anzalone, N.; Taylor, C.M.; Waldrop, G.L.
Crystal structure of carboxyltransferase from Staphylococcus aureus bound to the antibacterial agent moiramide B
Biochemistry
55
4666-4674
2016
Staphylococcus aureus
brenda
Keereetaweep, J.; Liu, H.; Zhai, Z.; Shanklin, J.
Biotin attachment domain-containing proteins irreversibly inhibit acetyl CoA carboxylase
Plant Physiol.
177
208-215
2018
Arabidopsis thaliana
brenda
Shivaiah, K.K.; Ding, G.; Upton, B.; Nikolau, B.J.
Non-catalytic subunits facilitate quaternary organization of plastidic acetyl-CoA carboxylase
Plant Physiol.
182
756-775
2020
Arabidopsis thaliana (Q9LD43 and P56765)
brenda
Pawelczyk, J.; Viljoen, A.; Kremer, L.; Dziadek, J.
The influence of AccD5 on AccD6 carboxyltransferase essentiality in pathogenic and non-pathogenic Mycobacterium
Sci. Rep.
7
42692
2017
Mycobacterium tuberculosis, Mycolicibacterium smegmatis, Mycobacterium tuberculosis H37Rv, Mycolicibacterium smegmatis mc(2)155
brenda