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3 S-adenosyl-L-methionine + phosphoethanolamine
3 S-adenosyl-L-homocysteine + phosphocholine
ethanolamine phosphate + S-adenosyl-L-methionine
N-methylethanolamine phosphate + S-adenosyl-L-homocysteine
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
choline phosphate + S-adenosyl-L-homocysteine
N-methylethanolamine phosphate + S-adenosyl-L-methionine
N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
S-adenosyl-L-methionine + N,N-dimethylethanolamine phosphate
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + phosphomonomethylethanolamine
S-adenosyl-L-methionine + phosphomonomethylethanolamine
S-adenosyl-L-homocysteine + phosphodimethylethanolamine
additional information
?
-
3 S-adenosyl-L-methionine + phosphoethanolamine
3 S-adenosyl-L-homocysteine + phosphocholine
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + phosphoethanolamine
3 S-adenosyl-L-homocysteine + phosphocholine
-
-
-
-
?
3 S-adenosyl-L-methionine + phosphoethanolamine
3 S-adenosyl-L-homocysteine + phosphocholine
overall reaction
-
-
?
ethanolamine phosphate + S-adenosyl-L-methionine
N-methylethanolamine phosphate + S-adenosyl-L-homocysteine
-
-
-
?
ethanolamine phosphate + S-adenosyl-L-methionine
N-methylethanolamine phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
choline phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
choline phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
choline phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
choline phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N-methylethanolamine phosphate + S-adenosyl-L-methionine
N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N-methylethanolamine phosphate + S-adenosyl-L-methionine
N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N-methylethanolamine phosphate + S-adenosyl-L-methionine
N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N-methylethanolamine phosphate + S-adenosyl-L-methionine
N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in production of free choline
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
main step in phosphocholine biosynthesis. Inhibition of phosphocholine biosynthesis in xpl1 mutants not only alters several root developmental traits but also induces cell death in root epidermal cells
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
first reaction of a pathway for phosphocholine biosynthesis. PMT-1 functions at a step before monomethylethanolamine enters the plant-like phosphobase methylation pathway
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
the enzyme plays an important role in the biosynthetic pathway of phosphatidylcholine by providing the precursor phosphocholine via a three step S-adenosyl-L-methionine-dependent methylation of phosphoethanolamine. The enzyme function is directly coupled to the Kennedy pathway
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
plays a critical role in the synthesis of phosphatidylcholine via the serine decarboxylase-phosphoethanolamine methyltransferase pathway
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
B3L8G9
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in production of free choline
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in production of free choline
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in production of free choline
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
reaction catalyzed by isozyme PMT2
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
reaction not catalyzed by phosphoethanolamine N-methyltransferase but by another enzyme
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
reaction not catalyzed by phosphoethanolamine N-methyltransferase but by another enzyme
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
poor substrate
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
first step in the PEAMTpathway, i.e. S-adenosyl-L-methionine:phosphoethanolamine N-methyltransferases pathway, the enzyme pmt-1 is required for worm growth and development
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
Plasmodium falciparum PMT plays a critical role in the synthesis of phosphatidylcholine via a plant-like pathway involving serine decarboxylation and phosphoethanolamine methylation
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
the enzyme catalyzes one step of the the three-step methylation of phosphoethanolamine to phosphocholine
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
the phosphoethanolamine methyltransferase is a critical enzyme in the the plant-like serine decarboxylase-phosphoethanolamine methyltransferase, SDPM, pathway, and is downregulated at the transcriptional level as well as targeted for degradation by the proteasome in the presence of choline
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
amino acids Asp61, Gly83, and Asp128 play a critical role in enzyme activity. Asp-61 is located within the VLDIGSGLG motif I of PfPMT conserved in all PMTs, mutational analysis of PfPMT substrate binding, overview
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
ZmPEAMT1 maybe involved in maize root development and stress resistance
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + phosphomonomethylethanolamine
-
reaction catalyzed by isozyme PMT1
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + phosphomonomethylethanolamine
-
-
-
?
S-adenosyl-L-methionine + phosphomonomethylethanolamine
S-adenosyl-L-homocysteine + phosphodimethylethanolamine
-
reaction catalyzed by isozyme PMT2
-
-
?
S-adenosyl-L-methionine + phosphomonomethylethanolamine
S-adenosyl-L-homocysteine + phosphodimethylethanolamine
-
-
-
?
additional information
?
-
-
PMEAMT cannot use phosphoethanolamine as a substrate, but assays using phosphomethylethanolamine as a substrate result in both phosphodimethylethanolamine and phosphocholine as products. PMEAMT is inhibited by the reaction products PCho and S-adenosyl-L-homocysteine
-
-
?
additional information
?
-
PMEAMT cannot use phosphoethanolamine as a substrate, but assays using phosphomethylethanolamine as a substrate result in both phosphodimethylethanolamine and phosphocholine as products. PMEAMT is inhibited by the reaction products PCho and S-adenosyl-L-homocysteine
-
-
?
additional information
?
-
-
the enzyme cannot use phosphoethanolamine as substrate
-
-
?
additional information
?
-
the enzyme cannot use phosphoethanolamine as substrate
-
-
?
additional information
?
-
the two NMT2 isoforms have the in vitro capacity to catalyze the triple methylation of phosphoethanolamine to produce choline phosphate, but with different efficiencies
-
-
-
additional information
?
-
-
the two NMT2 isoforms have the in vitro capacity to catalyze the triple methylation of phosphoethanolamine to produce choline phosphate, but with different efficiencies
-
-
-
additional information
?
-
-
the transcript levels of S-adenosyl-L-methionine synthetase are coregulated with those of phosphoethanolamine N-methyltransferase and choline monooxygenase to supply S-adenosyl-L-methionine for betaine synthesis in the leaves
-
-
?
additional information
?
-
no substrate: phosphomonomethylethanolamine
-
-
-
additional information
?
-
the enzyme shows no methyltransferase activity with phosphomonomethylethanolamine
-
-
-
additional information
?
-
no substrate: phosphomonomethylethanolamine
-
-
-
additional information
?
-
the enzyme shows no methyltransferase activity with phosphomonomethylethanolamine
-
-
-
additional information
?
-
no substrate: phosphomonomethylethanolamine
-
-
-
additional information
?
-
the enzyme shows no methyltransferase activity with phosphomonomethylethanolamine
-
-
-
additional information
?
-
no substrate: phosphomonomethylethanolamine
-
-
-
additional information
?
-
the enzyme shows no methyltransferase activity with phosphomonomethylethanolamine
-
-
-
additional information
?
-
-
no activity with phosphomethylethanolamine and phosphodimethylethanolamine
-
-
?
additional information
?
-
-
no activity with phosphomethylethanolamine and phosphodimethylethanolamine
-
-
?
additional information
?
-
-
isozyme PMT2 does not accept phosphoethanolamine as substrate
-
-
?
additional information
?
-
isoform PMT1 catalyzes the first step of the reactions, leading to the formation of phosphomonomethylethanolamine and the release of S-adenosylhomocysteine
-
-
-
additional information
?
-
isoform PMT1 catalyzes the first step of the reactions, leading to the formation of phosphomonomethylethanolamine and the release of S-adenosylhomocysteine
-
-
-
additional information
?
-
isoform PMT2 catalyzes the methylation of N-methylethanolamine phosphate to phosphodimethylethanolamine and subsequent methylation of phosphodimethylethanolamine to phosphocholine, releasing S-adenosyl-L-homocysteine at each methylation step
-
-
-
additional information
?
-
isoform PMT2 catalyzes the methylation of N-methylethanolamine phosphate to phosphodimethylethanolamine and subsequent methylation of phosphodimethylethanolamine to phosphocholine, releasing S-adenosyl-L-homocysteine at each methylation step
-
-
-
additional information
?
-
-
no activity with ethanolamine, methylethanolamine and dimethylethanolamine
-
-
?
additional information
?
-
-
no activity with phosphomethylethanolamine and phosphodimethylethanolamine
-
-
?
additional information
?
-
-
enzyme is directly coupled to the Kennedy pathway for the de novo synthesis of phosphatidylcholine
-
-
?
additional information
?
-
enzyme is directly coupled to the Kennedy pathway for the de novo synthesis of phosphatidylcholine
-
-
?
additional information
?
-
enzyme is involved in biosynthesis of phosphatidylcholine via phosphoethanolamine methylation. Model of pathway
-
-
?
additional information
?
-
-
enzyme is involved in biosynthesis of phosphatidylcholine via phosphoethanolamine methylation. Model of pathway
-
-
?
additional information
?
-
-
no substrate: phosphatidyl ethanolamine
-
-
?
additional information
?
-
no substrate: phosphatidyl ethanolamine
-
-
?
additional information
?
-
-
the transmethylation of phosphatidylethanolamine plays a role in the biosynthesis of phosphatidylcholine via the serine-decarboxylase phosphoethanolamine-methyltransferase pathway, which is important in the parasite's growth and survival, overview
-
-
?
additional information
?
-
-
no activity with phosphodimethylethanolamine
-
-
?
additional information
?
-
-
no activity with phosphodimethylethanolamine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
additional information
?
-
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in production of free choline
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
main step in phosphocholine biosynthesis. Inhibition of phosphocholine biosynthesis in xpl1 mutants not only alters several root developmental traits but also induces cell death in root epidermal cells
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
first reaction of a pathway for phosphocholine biosynthesis. PMT-1 functions at a step before monomethylethanolamine enters the plant-like phosphobase methylation pathway
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
the enzyme plays an important role in the biosynthetic pathway of phosphatidylcholine by providing the precursor phosphocholine via a three step S-adenosyl-L-methionine-dependent methylation of phosphoethanolamine. The enzyme function is directly coupled to the Kennedy pathway
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
plays a critical role in the synthesis of phosphatidylcholine via the serine decarboxylase-phosphoethanolamine methyltransferase pathway
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
B3L8G9
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in production of free choline
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in production of free choline
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in production of free choline
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
first step in the PEAMTpathway, i.e. S-adenosyl-L-methionine:phosphoethanolamine N-methyltransferases pathway, the enzyme pmt-1 is required for worm growth and development
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
Plasmodium falciparum PMT plays a critical role in the synthesis of phosphatidylcholine via a plant-like pathway involving serine decarboxylation and phosphoethanolamine methylation
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
the enzyme catalyzes one step of the the three-step methylation of phosphoethanolamine to phosphocholine
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
the phosphoethanolamine methyltransferase is a critical enzyme in the the plant-like serine decarboxylase-phosphoethanolamine methyltransferase, SDPM, pathway, and is downregulated at the transcriptional level as well as targeted for degradation by the proteasome in the presence of choline
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
ZmPEAMT1 maybe involved in maize root development and stress resistance
-
-
?
additional information
?
-
-
the transcript levels of S-adenosyl-L-methionine synthetase are coregulated with those of phosphoethanolamine N-methyltransferase and choline monooxygenase to supply S-adenosyl-L-methionine for betaine synthesis in the leaves
-
-
?
additional information
?
-
-
enzyme is directly coupled to the Kennedy pathway for the de novo synthesis of phosphatidylcholine
-
-
?
additional information
?
-
enzyme is directly coupled to the Kennedy pathway for the de novo synthesis of phosphatidylcholine
-
-
?
additional information
?
-
enzyme is involved in biosynthesis of phosphatidylcholine via phosphoethanolamine methylation. Model of pathway
-
-
?
additional information
?
-
-
enzyme is involved in biosynthesis of phosphatidylcholine via phosphoethanolamine methylation. Model of pathway
-
-
?
additional information
?
-
-
the transmethylation of phosphatidylethanolamine plays a role in the biosynthesis of phosphatidylcholine via the serine-decarboxylase phosphoethanolamine-methyltransferase pathway, which is important in the parasite's growth and survival, overview
-
-
?
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Datko, A.H.; Mudd, H.S.
Enzymes of phosphatidylcholine synthesis in lemna, soybean, and carrot
Plant Physiol.
88
1338-1348
1988
Daucus carota, Glycine max, Lemna aequinoctialis
brenda
Andriamampandry, C.; Massarelli, R.; Freysz, L.; Kanfer, J.N.
A rat brain cytosolic N-methyltransferase(s) activity converting phosphorylethanolamine into phosphorylcholine
Biochem. Biophys. Res. Commun.
171
758-763
1990
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Andriamampandry, C.; Massarelli, R.; Kanfer, J.N.
Properties of a partially purified phosphodimethylethanolamine methyltransferase from rat brain cytosol
Biochem. J.
288
267-272
1992
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Weretilnyk, E.A.; Smith, D.D.; Wilch, G.A.; Summers, P.S.
Enzymes of choline synthesis in spinach. Response of phospho-base N-methyltransferase activities to light and salinity
Plant Physiol.
109
1085-1091
1995
Spinacia oleracea
brenda
Nuccio, M.L.; Ziemak, M.J.; Henry, S.A.; Weretilnyk, E.A.; Hanson, A.D.
cDNA cloning of phosphoethanolamine N-methyltransferase from spinach by complementation in Schizosaccharomyces pombe and characterization of the recombinant enzyme
J. Biol. Chem.
275
14095-14101
2000
Spinacia oleracea (Q9M571), Spinacia oleracea
brenda
Bolognese, C.P.; McGraw, P.
The isolation and characterization in yeast of a gene for Arabidopsis S-adenosylmethionine:phospho-ethanolamine N-methyltransferase
Plant Physiol.
124
1800-1813
2000
Arabidopsis thaliana (Q9FR44)
brenda
Lorenzin, D.; Webb, C.; Summers, P.S.; Weretilnyk, E.A.
Enzymes of choline synthesis in diverse plants: Variation in phospho-base N-methyltransferase activities
Can. J. Bot.
79
897-904
2001
Amaranthus caudatus, Beta vulgaris, Glycine max, Gossypium hirsutum, Limonium perezii, Pisum sativum, Spinacia oleracea
brenda
McNeil, S.D.; Nuccio, M.L.; Ziemak, M.J.; Hanson, A.D.
Enhanced synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N-methyltransferase
Proc. Natl. Acad. Sci. USA
98
10001-10005
2001
Nicotiana tabacum
brenda
Mou, Z.; Wang, X.; Fu, Z.; Dai, Y.; Han, C.; Ouyang, J.; Bao, F.; Hu, Y.; Li, J.
Silencing of phosphoethanolamine N-methyltransferase results in temperature-sensitive male sterility and salt hypersensitivity in Arabidopsis
Plant Cell
14
2031-2043
2002
Arabidopsis thaliana (Q9FR44)
brenda
Charron, J.B.F.; Breton, G.; Danyluk, J.; Muzac, I.; Ibrahim, R.K.; Sarhan, F.
Molecular and biochemical characterization of a cold-regulated phosphoethanolamine N-methyltransferase from wheat
Plant Physiol.
129
363-373
2002
Triticum aestivum (Q8VYX1), Triticum aestivum
brenda
Smith, D.D.; Summers, P.S.; Weretilnyk, E.A.
Phosphocholine synthesis in spinach: characterization of phosphoethanolamine N-methyltransferase
Physiol. Plant.
108
286-294
2000
Spinacia oleracea
-
brenda
Pessi, G.; Choi, J.Y.; Reynolds, J.M.; Voelker, D.R.; Mamoun, C.B.
In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway
J. Biol. Chem.
280
12461-12466
2005
Plasmodium falciparum, Plasmodium falciparum (Q6T755)
brenda
Cruz-Ramirez, A.; Lopez-Bucio, J.; Ramirez-Pimentel, G.; Zurita-Silva, A.; Sanchez-Calderon, L.; Ramirez-Chavez, E.; Gonzalez-Ortega, E.; Herrera-Estrella, L.
The xipotl mutant of Arabidopsis reveals a critical role for phospholipid metabolism in root system development and epidermal cell integrity
Plant Cell
16
2020-2034
2004
Arabidopsis thaliana
brenda
Tabuchi, T.; Kawaguchi, Y.; Azuma, T.; Nanmori, T.; Yasuda, T.
Similar regulation patterns of choline monooxygenase, phosphoethanolamine N-methyltransferase and S-adenosyl-L-methionine synthetase in leaves of the halophyte Atriplex nummularia L
Plant Cell Physiol.
46
505-513
2005
Atriplex nummularia
brenda
Pessi, G.; Kociubinski, G.; Mamoun, C.B.
A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation
Proc. Natl. Acad. Sci. USA
101
6206-6211
2004
Plasmodium falciparum (Q6T755), Plasmodium falciparum
brenda
Brendza, K.M.; Haakenson, W.; Cahoon, R.E.; Hicks, L.M.; Palavalli, L.H.; Chiapelli, B.J.; McLaird, M.; McCarter, J.P.; Williams, D.J.; Hresko, M.C.; Jez, J.M.
Phosphoethanolamine N-methyltransferase (PMT-1) catalyzes the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans
Biochem. J.
404
439-448
2007
Caenorhabditis elegans
brenda
Tabuchi, T.; Okada, T.; Azuma, T.; Nanmori, T.; Yasuda, T.
Posttranscriptional regulation by the upstream open reading frame of the phosphoethanolamine N-methyltransferase gene
Biosci. Biotechnol. Biochem.
70
2330-2334
2006
Arabidopsis sp., Spinacia oleracea (Q9M571)
brenda
Witola, W.H.; Pessi, G.; El Bissati, K.; Reynolds, J.M.; Mamoun, C.B.
Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus
J. Biol. Chem.
281
21305-21311
2006
Plasmodium falciparum
brenda
Witola, W.H.; Ben Mamoun, C.
Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase
Eukaryot. Cell
6
1618-1624
2007
Plasmodium falciparum
brenda
Witola, W.H.; El Bissati, K.; Pessi, G.; Xie, C.; Roepe, P.D.; Ben Mamoun, C.
Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the SDPM pathway and severe growth and survival defects
J. Biol. Chem.
283
27636-27643
2008
Plasmodium falciparum
brenda
Reynolds, J.M.; Takebe, S.; Choi, J.Y.; El Bissati, K.; Witola, W.H.; Bobenchik, A.M.; Hoch, J.C.; Voelker, D.R.; Mamoun, C.B.
Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum
J. Biol. Chem.
283
7894-7900
2008
Plasmodium falciparum (Q6T755), Plasmodium falciparum
brenda
Wu, S.; Yu, Z.; Wang, F.; Li, W.; Ye, C.; Li, J.; Tang, J.; Ding, J.; Zhao, J.; Wang, B.
Cloning, characterization, and transformation of the phosphoethanolamine N-methyltransferase gene (ZmPEAMT1) in maize (Zea mays L.)
Mol. Biotechnol.
36
102-112
2007
Zea mays (Q5SDQ0), Zea mays
brenda
Bezsonova, I.; Rujan, I.; Bobenchik, A.M.; Gorbatyuk, V.; Maciejewski, M.W.; Gorbatyuk, O.; Hao, B.; Arthanari, H.; Mamoun, C.B.; Hoch, J.C.
1H, 13C, and 15N chemical shift assignments for PfPMT, a phosphoethanolamine methyltransferase from Plasmodium falciparum
Biomol. NMR Assign.
7
17-20
2013
Plasmodium falciparum
brenda
Bobenchik, A.M.; Choi, J.Y.; Mishra, A.; Rujan, I.N.; Hao, B.; Voelker, D.R.; Hoch, J.C.; Mamoun, C.B.
Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay
BMC Biochem.
11
4-4
2010
Plasmodium falciparum
brenda
BeGora, M.D.; Macleod, M.J.; McCarry, B.E.; Summers, P.S.; Weretilnyk, E.A.
Identification of phosphomethylethanolamine N-methyltransferase from Arabidopsis and its role in choline and phospholipid metabolism
J. Biol. Chem.
285
29147-29155
2010
Arabidopsis thaliana, Arabidopsis thaliana (Q944H0)
brenda
Lee, S.G.; Haakenson, W.; McCarter, J.P.; Williams, D.J.; Hresko, M.C.; Jez, J.M.
Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortus
J. Biol. Chem.
286
38060-38068
2011
Haemonchus contortus
brenda
Lee, S.G.; Kim, Y.; Alpert, T.D.; Nagata, A.; Jez, J.M.
Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target
J. Biol. Chem.
287
1426-1434
2012
Plasmodium falciparum (Q6T755), Plasmodium falciparum
brenda
Lee, S.G.; Alpert, T.D.; Jez, J.M.
Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine
Bioorg. Med. Chem. Lett.
22
4990-4993
2012
Plasmodium falciparum (Q6T755), Plasmodium falciparum
brenda
Yuan, Y.; Qi, L.; Yu, J.; Wang, X.; Huang, L.
Transcriptome-wide analysis of SAMe superfamily to novelty phosphoethanolamine N-methyltransferase copy in Lonicera japonica
Int. J. Mol. Sci.
16
521-534
2015
Lonicera japonica
brenda
Saen-Oon, S.; Lee, S.G.; Jez, J.M.; Guallar, V.
An alternative mechanism for the methylation of phosphoethanolamine catalyzed by Plasmodium falciparum phosphoethanolamine methyltransferase
J. Biol. Chem.
289
33815-33825
2014
Plasmodium falciparum (Q6T755), Plasmodium falciparum
brenda
Bobenchik, A.M.; Witola, W.H.; Augagneur, Y.; Nic Lochlainn, L.; Garg, A.; Pachikara, N.; Choi, J.Y.; Zhao, Y.O.; Usmani-Brown, S.; Lee, A.; Adjalley, S.H.; Samanta, S.; Fidock, D.A.; Voelker, D.R.; Fikrig, E.; Ben Mamoun, C.
Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission
Proc. Natl. Acad. Sci. USA
110
18262-18267
2013
Plasmodium falciparum (Q8IDQ9), Plasmodium falciparum
brenda
Garg, A.; Lukk, T.; Kumar, V.; Choi, J.Y.; Augagneur, Y.; Voelker, D.R.; Nair, S.; Ben Mamoun, C.
Structure, function and inhibition of the phosphoethanolamine methyltransferases of the human malaria parasites Plasmodium vivax and Plasmodium knowlesi
Sci. Rep.
5
9064
2015
Plasmodium knowlesi (B3L8G9), Plasmodium knowlesi, Plasmodium vivax (A5K867), Plasmodium vivax
brenda
Li, Q.; Xie, J.; Ma, X.; Li, D.
Molecular cloning of phosphoethanolamine N-methyltransferase (PEAMT) gene and its promoter from the halophyte Suaeda liaotungensis and their response to salt stress
Acta Physiol. Plant.
38
39
2016
Suaeda liaotungensis (A0N067)
-
brenda
Hirashima, T.; Toyoshima, M.; Moriyama, T.; Nakamura, Y.; Sato, N.
Characterization of phosphoethanolamine-N-methyltransferases in green algae
Biochem. Biophys. Res. Commun.
488
141-146
2017
Chlamydomonas asymmetrica (A0A125SQH6), Chlamydomonas applanata (A0A1W7HP20), Chlamydomonas asymmetrica NIES-2207 (A0A125SQH6), Chlamydomonas applanata NIES-2202 (A0A1W7HP20)
brenda
Singh, J.; Mansuri, R.; Vijay, S.; Sahoo, G.C.; Sharma, A.; Kumar, M.
Docking predictions based Plasmodium falciparum phosphoethanolamine methyl transferase inhibitor identification and in-vitro antimalarial activity analysis
BMC Chem.
13
43
2019
Plasmodium falciparum (Q6T755), Plasmodium falciparum
brenda
Lee, S.G.; Jez, J.M.
Conformational changes in the di-domain structure of Arabidopsis phosphoethanolamine methyltransferase leads to active-site formation
J. Biol. Chem.
292
21690-21702
2017
Arabidopsis thaliana (Q944H0), Arabidopsis thaliana (Q9C6B9), Arabidopsis thaliana (Q9FR44)
brenda
Zou, Y.; Zhang, X.; Tan, Y.; Huang, J.B.; Zheng, Z.; Tao, L.Z.
Phosphoethanolamine N-methyltransferase 1 contributes to maintenance of root apical meristem by affecting ROS and auxin-regulated cell differentiation in Arabidopsis
New Phytol.
224
258-273
2019
Arabidopsis thaliana (Q9FR44)
brenda
Chen, W.; Taylor, M.C.; Barrow, R.A.; Croyal, M.; Masle, J.
Loss of phosphoethanolamine N-methyltransferases abolishes phosphatidylcholine synthesis and is lethal
Plant Physiol.
179
124-142
2019
Arabidopsis thaliana (Q944H0), Arabidopsis thaliana
brenda
Krause, R.; Goldring, J.
Phosphoethanolamine-N-methyltransferase is a potential biomarker for the diagnosis of P. knowlesi and P. falciparum malaria
PLoS ONE
13
e0193833
2018
Plasmodium knowlesi, Plasmodium vivax (A5K867), Plasmodium vivax, Plasmodium falciparum (Q6T755), Plasmodium falciparum, Plasmodium vivax Salvador I (A5K867)
brenda
Witola, W.H.; Cooks-Fagbodun, S.; Ordonez, A.R.; Matthews, K.; Abugri, D.A.; McHugh, M.
Knockdown of phosphoethanolamine transmethylation enzymes decreases viability of Haemonchus contortus
Vet. Parasitol.
223
1-6
2016
Haemonchus contortus (A0A2Z1FIB9), Haemonchus contortus (U5HK48)
brenda