Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB CommentsThe enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the desaturation of the C-3,4 double bond in dihydroisopentenyldehydrorhodopin and the desaturation of the C-3',4' double bond in dihydrobisanhydrobacterioruberin.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,1'-dihydroxy-3,4-didehydrolycopene + acceptor
1,1'-dihydroxy-3,4,3',4'-tetradehydrolycopene + reduced acceptor
-
38% conversion
-
?
1,1'-dihydroxyneurosporene + acceptor
1'-hydroxydemethylspheroidene + reduced acceptor
-
39% conversion
-
?
1-hydroxy-3',4'-didehydrolycopene + acceptor
1'-hydroxy-3,4,3',4'-tetradehydrolycopene + reduced acceptor
-
28% conversion
-
?
1-hydroxy-neurosporene + acceptor
demethylspheroidene + reduced acceptor
-
47% conversion
-
?
1-hydroxylycopene + acceptor
1-hydroxy-3,4-didehydrolycopene + reduced acceptor
-
33% conversion
-
?
1-methoxy-1'-hydroxy-3,4-didehydrolycopene + acceptor
1-methoxy-1'-hydroxy-3,4,3',4'-tetradehydrolycopene + reduced acceptor
-
37% conversion
-
r
3,4-didehydrorhodopin + acceptor
3,4,3',4'-tetradehydrorhodopin + reduced acceptor
-
asymmetric carotenoid containing 14 conjugated double bonds, produced by molecular variation of CrtD
-
?
anhydrorhodovibrin + acceptor
3',4'-didehydroanhydrorhodovibrin + reduced acceptor
-
asymmetric carotenoid containing 14 conjugated double bonds, produced by molecular variation of CrtD
-
?
dihydrobisanhydrobacterioruberin + acceptor
bisanhydrobacterioruberin + reduced acceptor
dihydroisopentenyldehydrorhodopin + acceptor
isopentenyldehydrorhodopin + reduced acceptor
rhodopin + acceptor
3,4-didehydrorhodopin + reduced acceptor
-
-
-
?
rhodovibrin + acceptor
monodemethylated spirilloxanthin + reduced acceptor
-
-
-
?
additional information
?
-
dihydrobisanhydrobacterioruberin + acceptor
bisanhydrobacterioruberin + reduced acceptor
the enzyme is involved in biosynthesis of the C50 carotenoid bacterioruberin
-
-
?
dihydrobisanhydrobacterioruberin + acceptor
bisanhydrobacterioruberin + reduced acceptor
the enzyme forms a double bond at C-3',4'
-
-
?
dihydroisopentenyldehydrorhodopin + acceptor
isopentenyldehydrorhodopin + reduced acceptor
the enzyme is involved in biosynthesis of the C50 carotenoid bacterioruberin
-
-
?
dihydroisopentenyldehydrorhodopin + acceptor
isopentenyldehydrorhodopin + reduced acceptor
the enzyme forms a double bound at C-3,4
-
-
?
additional information
?
-
the enzyme forms double bonds at C-3,4 and C-3',4' of the lycopene derivatives
-
-
?
additional information
?
-
-
the enzyme forms double bonds at C-3,4 and C-3',4' of the lycopene derivatives
-
-
?
additional information
?
-
-
variations in carotenoid composition found in the Rhodoplanes species might be due to modified substrate specificity of the carotenogenesis enzymes, CrtC, CrtD, and CrtF. The high content of rhodopin in Rhodoplanes cryptolactis and Rhodoplanes pokkaliisoli indicates low activity of CrtD
-
-
?
additional information
?
-
The 3,4-desaturation reaction can only occur with mono-1-hydroxy carotenoids at a psi-end group or with 1,1'-dihydroxy derivatives carrying a 3',4'-double bond. 1-OH-zeta-carotene can also be converted by the desaturase. 1-OH-neurosporene is preferred over 1-OH-lycopene. No substrates are 1'-hydroxydemethylspheroidene, 1-methoxyneurosporene, 1,1'-dihydroxylycopene
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CRTD_HALJT
Haloarcula japonica (strain ATCC 49778 / DSM 6131 / JCM 7785 / NBRC 101032 / NCIMB 13157 / TR-1)
495
0
55506
Swiss-Prot
-
A0A0K1IVT4_HALGI
500
0
55776
TrEMBL
-
A0A2H1XRB4_9FLAO
487
0
54999
TrEMBL
-
A0A653UPY0_9FLAO
485
0
55001
TrEMBL
-
A0A653XQ24_9FLAO
488
0
55193
TrEMBL
-
A0A654E2I7_9BACT
489
0
55120
TrEMBL
-
A0A653YRF0_9ACTN
536
0
56899
TrEMBL
-
A0A2I2M9U3_9FLAO
487
0
54933
TrEMBL
-
A0A653RJY7_9FLAO
488
0
55037
TrEMBL
-
D4GTW0_HALVD
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
500
0
55874
TrEMBL
-
A0A4D6GXS8_HALS9
Halobacterium salinarum (strain ATCC 33171 / DSM 3754 / JCM 8978 / NBRC 102687 / NCIMB 764 / 91-R6)
512
0
56274
TrEMBL
-
A0A5E4LAF8_9ARCH
507
0
55675
TrEMBL
-
B0R652_HALS3
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
512
0
56274
TrEMBL
-
A0A5E7XPD1_9BACT
492
0
55813
TrEMBL
-
G0LJV3_HALWC
Haloquadratum walsbyi (strain DSM 16854 / JCM 12705 / C23)
500
0
56146
TrEMBL
-
A0A653TSK7_9MICO
532
0
56920
TrEMBL
-
A0A653LSI5_9MICO
567
0
61174
TrEMBL
-
A0A653LI90_9MICO
522
1
56722
TrEMBL
-
A0A653S3S9_9MICO
526
0
56942
TrEMBL
-
Q18GC9_HALWD
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
500
0
56088
TrEMBL
-
M1XL66_NATM8
Natronomonas moolapensis (strain DSM 18674 / CECT 7526 / JCM 14361 / 8.8.11)
492
0
55204
TrEMBL
-
A0A1U7EZ00_NATPD
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)
492
0
55226
TrEMBL
-
A0A653QJW4_9MICO
546
1
59528
TrEMBL
-
A0A2I2M4E8_9FLAO
487
0
54948
TrEMBL
-
A0A7G9YU85_9EURY
253
0
28839
TrEMBL
-
A0A2H1YHW9_9FLAO
489
0
55258
TrEMBL
-
A0A2H1XSF5_9FLAO
487
0
54974
TrEMBL
-
A0A7G2D0V6_9MICO
530
0
56914
TrEMBL
-
Q9HPD8_HALSA
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
512
0
56274
TrEMBL
-
A0A2H1Y713_9FLAO
487
0
54943
TrEMBL
-
A0A0U5H2H0_9EURY
511
0
56823
TrEMBL
-
CRTDH_NONDD
Nonlabens dokdonensis (strain DSM 17205 / KCTC 12402 / DSW-6)
487
0
54767
Swiss-Prot
other Location (Reliability: 4)
Q8GDC9_RHORU
491
0
51730
TrEMBL
Mitochondrion (Reliability: 5)
CRTD_RUBGE
525
0
56671
Swiss-Prot
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Steiger, S.; Astier, C.; Sandmann, G.
Substrate specificity of the expressed carotenoid 3,4-desaturase from Rubrivivax gelatinosus reveals the detailed reaction sequence to spheroidene and spirilloxanthin
Biochem. J.
349
635-640
2000
Rubrivivax gelatinosus (Q9JPB5)
brenda
Takaichi, S.; Sasikala, C.h.; Ramana, C.h.V.; Okamura, K.; Hiraishi, A.
Carotenoids in Rhodoplanes species: variation of compositions and substrate specificity of predicted carotenogenesis enzymes
Curr. Microbiol.
65
150-155
2012
Rhodoplanes sp.
brenda
Yang, Y.; Yatsunami, R.; Ando, A.; Miyoko, N.; Fukui, T.; Takaichi, S.; Nakamura, S.
Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica
J. Bacteriol.
197
1614-1623
2015
Haloarcula japonica (A0A0A1GKA2), Haloarcula japonica
brenda
Autenrieth, C.; Ghosh, R.
Random mutagenesis and overexpression of rhodopin-3,4-desaturase allows the production of highly conjugated carotenoids in Rhodospirillum rubrum
Arch. Biochem. Biophys.
572
134-141
2015
Rhodospirillum rubrum (Q8GDC9)
brenda
Ahn, J.W.; Kim, K.J.
Crystal structure of 1-OH-carotenoid 3,4-desaturase from Nonlabens dokdonensis DSW-6
Enzyme Microb. Technol.
77
29-37
2015
Nonlabens dokdonensis (L7WC64), Nonlabens dokdonensis DSW-6 (L7WC64)
brenda