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Information on EC 1.17.99.11 - 3-oxo-DELTA1-steroid hydratase/dehydrogenase

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EC Tree
IUBMB Comments
A molybdenum enzyme. The enzyme, characterized from the bacterium Steroidobacter denitrificans, is involved in the anaetrobic degradation of steroids. It is specific to 3-oxo-DELTA1-steroids such as androsta-1-ene-3,17-dione and DELTA1-dihydrotestosterone and does not act on 3-oxo-DELTA4-steroids.
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The expected taxonomic range for this enzyme is: Steroidobacter denitrificans
Reaction Schemes
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Synonyms
1-testosterone hydratase/dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 1-hydroxy-3-oxo-steroid + acceptor = a steroid 1,3-dione + reduced acceptor
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(1b)
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a 3-oxo-DELTA1-steroid + H2O + acceptor = a steroid 1,3-dione + reduced acceptor
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(overall reaction)
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a 3-oxo-DELTA1-steroid + H2O = a 1-hydroxy-3-oxo-steroid
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(1a)
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