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(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
overall reaction
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(+)-cis,trans-nepetalactol + [reduced NADPH-hemoprotein reductase] + O2 = 7-deoxyloganetic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
(1a)
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7-deoxyloganetic alcohol + [reduced NADPH-hemoprotein reductase] + O2 = iridotrial + [oxidized NADPH-hemoprotein reductase] + 2 H2O
(1b)
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iridotrial + [reduced NADPH-hemoprotein reductase] + O2 = 7-deoxyloganetate + [oxidized NADPH-hemoprotein reductase] + H2O
(1c)
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(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
(+)-cis,trans-nepetalactol + [reduced NADPH-hemoprotein reductase] + O2
7-deoxyloganetic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
7-deoxyloganetic alcohol + [reduced NADPH-hemoprotein reductase] + O2
iridotrial + [oxidized NADPH-hemoprotein reductase] + 2 H2O
iridotrial + [reduced NADPH-hemoprotein reductase] + O2
7-deoxyloganetate + [oxidized NADPH-hemoprotein reductase] + H2O
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction
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-
?
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction
-
-
?
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction
-
-
?
(+)-cis,trans-nepetalactol + [reduced NADPH-hemoprotein reductase] + O2
7-deoxyloganetic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids
-
-
?
(+)-cis,trans-nepetalactol + [reduced NADPH-hemoprotein reductase] + O2
7-deoxyloganetic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids
-
-
?
(+)-cis,trans-nepetalactol + [reduced NADPH-hemoprotein reductase] + O2
7-deoxyloganetic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids
-
-
?
7-deoxyloganetic alcohol + [reduced NADPH-hemoprotein reductase] + O2
iridotrial + [oxidized NADPH-hemoprotein reductase] + 2 H2O
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids
-
-
?
7-deoxyloganetic alcohol + [reduced NADPH-hemoprotein reductase] + O2
iridotrial + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids
-
-
?
7-deoxyloganetic alcohol + [reduced NADPH-hemoprotein reductase] + O2
iridotrial + [oxidized NADPH-hemoprotein reductase] + 2 H2O
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids
-
-
?
iridotrial + [reduced NADPH-hemoprotein reductase] + O2
7-deoxyloganetate + [oxidized NADPH-hemoprotein reductase] + H2O
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids
-
-
?
iridotrial + [reduced NADPH-hemoprotein reductase] + O2
7-deoxyloganetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids
-
-
?
iridotrial + [reduced NADPH-hemoprotein reductase] + O2
7-deoxyloganetate + [oxidized NADPH-hemoprotein reductase] + H2O
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids
-
-
?
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(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction
-
-
?
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction
-
-
?
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction
-
-
?
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malfunction
virus-induced gene silencing of 7-deoxyloganetic acid synthase in Catharanthus roseus greatly decreases levels of secologanin and the major monoterpenoid indole alkaloids, catharanthine and vindoline in silenced leaves
malfunction
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virus-induced gene silencing of 7-deoxyloganetic acid synthase in Catharanthus roseus greatly decreases levels of secologanin and the major monoterpenoid indole alkaloids, catharanthine and vindoline in silenced leaves
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metabolism
the enzyme catalyses three successive reactions in the seco-iridoid pathway leading to biosynthesis of monoterpenoid indole alkaloids
metabolism
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the enzyme catalyses three successive reactions in the seco-iridoid pathway leading to biosynthesis of monoterpenoid indole alkaloids
metabolism
the enzyme is involved in the monoterpenoid indole alkaloid pathway
metabolism
-
the enzyme catalyses three successive reactions in the seco-iridoid pathway leading to biosynthesis of monoterpenoid indole alkaloids
-
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Campbell, A.; Bauchart, P.; Gold, N.D.; Zhu, Y.; De Luca, V.; Martin, V.J.
Engineering of a nepetalactol-producing platform strain of Saccharomyces cerevisiae for the production of plant seco-iridoids
ACS Synth. Biol.
5
405-414
2016
Catharanthus roseus (W8JIS5)
brenda
Miettinen, K.; Dong, L.; Navrot, N.; Schneider, T.; Burlat, V.; Pollier, J.; Woittiez, L.; Van Der Krol, S.; Lugan, R.; Ilc, T.; Verpoorte, R.; Oksman-Caldentey, K.; Martinoia, E.; Bouwmeester, H.; Goossens, A.; Memelink, J.; Werck-Reichhart, D.
The seco-iridoid pathway from Catharanthus roseus
Nat. Commun.
5
3606
2014
Catharanthus roseus (W8JIS5)
brenda
Salim, V.; Wiens, B.; Masada-Atsumi, S.; Yu, F.; De Luca, V.
7-deoxyloganetic acid synthase catalyzes a key 3 step oxidation to form 7-deoxyloganetic acid in Catharanthus roseus iridoid biosynthesis
Phytochemistry
101
23-31
2014
Catharanthus roseus (W8JIS5), Catharanthus roseus, Catharanthus roseus cv. Little Delicata (W8JIS5)
brenda