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creatol + O2
methylguanidine + ?
-
creatone A and creatone B are intermediates
-
-
?
D-altrono-1,4-lactone + O2
?
D-glucono-1,4-lactone + O2
?
-
4% as active as L-gulono-1,4-lactone
-
-
?
D-glucono-1,4-lactone + O2
? + H2O2
-
-
-
?
D-glucose + phenazine methosulfate + O2
D-glucosone + ?
-
23.4% as active as L-gulono-1,4-lactone
-
-
?
D-mannono-1,4-lactone + O2
?
D-mannose + phenazine methosulfate + O2
?
-
6.4% as active as L-gulono-1,4-lactone
-
-
?
D-xylose + phenazine methosulfate + O2
D-xylosone + ?
-
6.4% as active as L-gulono-1,4-lactone
-
-
?
L-fructose + O2
?
-
-
-
?
L-galactono-1,4-lactone + O2
L-ascorbic acid + H2O2
L-glucono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
L-glucurono-1,4-lactone + phenazine methosulfate + O2
?
-
6.4% as active as L-gulono-1,4-lactone
-
-
?
L-gulono-1,4-lactone + 2,6-dichlorophenolindophenol + O2
L-ascorbic acid + ?
L-gulono-1,4-lactone + cytochrome C
L-ascorbate + ?
-
-
-
?
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
L-gulono-1,4-lactone + O2
L-xylo-hex-2-ulono-1,4-lactone + H2O2
-
-
-
-
r
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
L-gulono-1,4-lactone + phenazine methosulfate + O2
L-ascorbic acid + ?
L-idono-1,4-lactone + O2
?
-
3% as active as L-gulono-1,4-lactone
-
-
?
additional information
?
-
D-altrono-1,4-lactone + O2
?
-
16% as active as L-gulono-1,4-lactone
-
-
?
D-altrono-1,4-lactone + O2
?
-
-
-
-
?
D-mannono-1,4-lactone + O2
?
-
64% as active as L-gulono-1,4-lactone
-
-
?
D-mannono-1,4-lactone + O2
?
-
25% as active as L-gulono-1,4-lactone
-
-
?
L-galactono-1,4-lactone + O2
L-ascorbic acid + H2O2
-
-
-
?
L-galactono-1,4-lactone + O2
L-ascorbic acid + H2O2
-
90% as active as L-gulono-1,4-lactone
-
-
?
L-galactono-1,4-lactone + O2
L-ascorbic acid + H2O2
-
2% as active as L-gulono-1,4-lactone
-
-
?
L-galactono-1,4-lactone + O2
L-ascorbic acid + H2O2
-
-
-
?
L-galactono-1,4-lactone + O2
L-ascorbic acid + H2O2
-
-
-
-
?
L-glucono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
r
L-glucono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
r
L-gulono-1,4-lactone + 2,6-dichlorophenolindophenol + O2
L-ascorbic acid + ?
-
enzyme is a dehydrogenase, not an oxidase
-
-
?
L-gulono-1,4-lactone + 2,6-dichlorophenolindophenol + O2
L-ascorbic acid + ?
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
-
-
-
?
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
-
-
-
?
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
during the catalytic reaction by Gulo, flavin accepts 2 electrons from the substrate l-gulono-gamma-lactone, thus undergoing a reduction, followed by oxidation through molecular oxygen, with the reaction presumably involving the ALO domain. Through this process, 2-oxo-l-gulono-gamma-lactone and hydrogen peroxide are produced, and L-ascorbic acid is formed by nonenzymatic isomerisation of the former product
-
-
?
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
the enzyme has a configurational specificity for the hydroxyl group at C-2
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
the enzyme has a configurational specificity for the hydroxyl group at C(2)
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
636305, 636306, 636307, 636309, 636310, 636311, 636315, 636317, 636319, 636320, 636321, 636322, 636323, 636324, 636325 -
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
the enzyme has a configurational specificity for the hydroxyl group at C-2
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
the enzyme has a configurational specificity for the hydroxyl group at C(2)
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
key enzyme for L-ascorbic acid biosynthesis
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
product isomerizes spontaneously to L-ascorbate
?
L-gulono-1,4-lactone + phenazine methosulfate + O2
L-ascorbic acid + ?
-
enzyme is a dehydrogenase, not an oxidase
-
-
?
L-gulono-1,4-lactone + phenazine methosulfate + O2
L-ascorbic acid + ?
-
-
-
-
?
L-gulono-1,4-lactone + phenazine methosulfate + O2
L-ascorbic acid + ?
-
reaction also takes place under anaerobic conditions
-
-
?
additional information
?
-
the enzyme catalyzes the reaction of L-gulonolactone oxidase, EC 1.1.3.8, producting L-ascorbate, but has sequence similarities to D-arabinono-1,4-lactone oxidase, EC 1.1.3.37
-
-
?
additional information
?
-
the enzyme catalyzes the reaction of L-gulonolactone oxidase, EC 1.1.3.8, producting L-ascorbate, but has sequence similarities to D-arabinono-1,4-lactone oxidase, EC 1.1.3.37
-
-
?
additional information
?
-
the enzyme catalyzes the reaction of L-gulonolactone oxidase, EC 1.1.3.8, producting L-ascorbate, but has sequence similarities to D-arabinono-1,4-lactone oxidase, EC 1.1.3.37
-
-
?
additional information
?
-
no dehydrogenase or oxidase activity with L-galactono-1,4-lactone, D-galactono-1,4-lactone, and D-gluconic acid-gamma-lactone. No oxidase activity with L-gulono-1,4-lactone
-
-
-
additional information
?
-
no dehydrogenase or oxidase activity with L-galactono-1,4-lactone, D-galactono-1,4-lactone, and D-gluconic acid-gamma-lactone. No oxidase activity with L-gulono-1,4-lactone
-
-
-
additional information
?
-
no substrates: raffinose, mannose, sucrose, arabinose, and ascorbate
-
-
-
additional information
?
-
-
no substrates: raffinose, mannose, sucrose, arabinose, and ascorbate
-
-
-
additional information
?
-
examination of metabolic role of vitamin C synthesis in cells or animals that, during evolution, have lost the ability to make ascorbic acid
-
-
?
additional information
?
-
-
examination of metabolic role of vitamin C synthesis in cells or animals that, during evolution, have lost the ability to make ascorbic acid
-
-
?
additional information
?
-
-
presence of a alternative pathway for vitamin C production in plants which can circumvent steps of the D-mannose pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
additional information
?
-
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
-
-
-
?
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
during the catalytic reaction by Gulo, flavin accepts 2 electrons from the substrate l-gulono-gamma-lactone, thus undergoing a reduction, followed by oxidation through molecular oxygen, with the reaction presumably involving the ALO domain. Through this process, 2-oxo-l-gulono-gamma-lactone and hydrogen peroxide are produced, and L-ascorbic acid is formed by nonenzymatic isomerisation of the former product
-
-
?
L-gulono-1,4-lactone + O2
L-ascorbate + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
the enzyme has a configurational specificity for the hydroxyl group at C(2)
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
636305, 636306, 636307, 636309, 636310, 636311, 636315, 636317, 636319, 636320, 636321, 636322, 636323, 636324, 636325 -
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
the enzyme has a configurational specificity for the hydroxyl group at C(2)
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
key enzyme for L-ascorbic acid biosynthesis
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
L-gulono-1,4-lactone + O2
L-xylo-hex-3-ulonolactone + H2O2
-
-
-
-
?
additional information
?
-
the enzyme catalyzes the reaction of L-gulonolactone oxidase, EC 1.1.3.8, producting L-ascorbate, but has sequence similarities to D-arabinono-1,4-lactone oxidase, EC 1.1.3.37
-
-
?
additional information
?
-
the enzyme catalyzes the reaction of L-gulonolactone oxidase, EC 1.1.3.8, producting L-ascorbate, but has sequence similarities to D-arabinono-1,4-lactone oxidase, EC 1.1.3.37
-
-
?
additional information
?
-
the enzyme catalyzes the reaction of L-gulonolactone oxidase, EC 1.1.3.8, producting L-ascorbate, but has sequence similarities to D-arabinono-1,4-lactone oxidase, EC 1.1.3.37
-
-
?
additional information
?
-
examination of metabolic role of vitamin C synthesis in cells or animals that, during evolution, have lost the ability to make ascorbic acid
-
-
?
additional information
?
-
-
examination of metabolic role of vitamin C synthesis in cells or animals that, during evolution, have lost the ability to make ascorbic acid
-
-
?
additional information
?
-
-
presence of a alternative pathway for vitamin C production in plants which can circumvent steps of the D-mannose pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ascorbic Acid Deficiency
Intragenic deletion in the gene encoding L-gulonolactone oxidase causes vitamin C deficiency in pigs.
Ascorbic Acid Deficiency
Requirement for ascorbic acid in a rat mutant unable to synthesize ascorbic acid.
Ascorbic Acid Deficiency
Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency.
Ascorbic Acid Deficiency
The L-gulono-gamma-lactone oxidase gene (GULO) which is a candidate for vitamin C deficiency in pigs maps to chromosome 14.
Ascorbic Acid Deficiency
Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- mice.
Carcinoma, Hepatocellular
Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1.
Carcinoma, Hepatocellular
Vitamin C deficiency aggravates tumor necrosis factor ?-induced insulin resistance.
Chronic Limb-Threatening Ischemia
Clinical and anatomical variables associated in the literature to limb graft occlusion after endovascular aneurysm repair compared to the experience of a tertiary referral center.
Deficiency Diseases
Intravascularly administered crosslinked immunoprecipitates of gulonolactone oxidase are toxic and rapidly cleared from the circulation.
Fractures, Spontaneous
Genome wide analysis of sex difference in gene expression profiles of bone formations using sfx mice and BXD RI strains.
Fractures, Spontaneous
Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells.
Fractures, Spontaneous
Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency.
Infections
In situ SEM, TEM and AFM studies of the antimicrobial activity of lemon grass oil in liquid and vapour phase against Candida albicans.
Infections
Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- mice.
Infections
Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation.
Influenza, Human
Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- mice.
Insulin Resistance
Vitamin C deficiency aggravates tumor necrosis factor ?-induced insulin resistance.
l-gulonolactone oxidase deficiency
A missense mutation of L-gulono-gamma-lactone oxidase causes the inability of scurvy-prone osteogenic disorder rats to synthesize L-ascorbic acid.
l-gulonolactone oxidase deficiency
Expression of the mutant gene for L-gulono-gamma-lactone oxidase in scurvy-prone rats.
l-gulonolactone oxidase deficiency
L-gulono-gamma-lactone oxidase deficiency in rats with osteogenic disorder: enzymological and immunochemical studies.
Neoplasms
Computational design of improved standardized chemotherapy protocols for grade II oligodendrogliomas.
Neoplasms
Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice.
Pancreatic Diseases
'Do research with seriousness and perseverance'. An interview with Prof. Lucio Gullo. Interview by Martin E. Fernandez-Zapico.
Parasitemia
Vitamin C deficiency fails to protect mice from malaria.
Riboflavin Deficiency
L-gulonolactone oxidase activity and vitamin C status in riboflavin-deficient rats.
Scurvy
A missense mutation of L-gulono-gamma-lactone oxidase causes the inability of scurvy-prone osteogenic disorder rats to synthesize L-ascorbic acid.
Scurvy
Body pool and synthesis of ascorbic acid in adult sea lamprey (Petromyzon marinus): An agnathan fish with gulonolactone oxidase activity
Scurvy
Differential gene expression between wild-type and Gulo-deficient mice supplied with vitamin C.
Scurvy
Feasibility of using an isolated intestinal segment as an artificial organ for enzyme replacement therapy.
Scurvy
Immunologic evidence that the gene for L-gulono-gamma-lactone oxidase is not expressed in animals subject to scurvy.
Scurvy
Intravascularly administered crosslinked immunoprecipitates of gulonolactone oxidase are toxic and rapidly cleared from the circulation.
Seizures
Genetic features of oligodendrogliomas and presence of seizures. The relationship of seizures and genetics in LGOs.
Tuberculosis
Mycobacterium tuberculosis possesses a functional enzyme for the synthesis of vitamin C, L-gulono-1,4-lactone dehydrogenase.
Vitamin E Deficiency
Formation of malonaldehyde in vitamin E deficiency and its relation to the inhibition of gulonolactone oxidase.
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Bleeg, H.S.; Christensen, F.
Biosynthesis of ascorbate in yeast. Purification of L-galactono-1,4-lactone oxidase with properties different from mammalian L-gulonolactone oxidase
Eur. J. Biochem.
127
391-396
1982
Saccharomyces cerevisiae
brenda
Nishikimi, M.; Noguchi, E.; Yagi, K.
Occurrence in yeast of L-galactonolactone oxidase which is similar to a key enzyme for ascorbic acid biosynthesis in animals, L-gulonolactone oxidase
Arch. Biochem. Biophys.
191
479-486
1978
Saccharomyces cerevisiae
brenda
Ching, S.; Mahan, D.C.; Dabrowski, K.
Liver L-gulonolactone oxidase activity and tissue ascorbic acid concentrations in nursing pigs and the effect of various weaning ages
J. Nutr.
131
2002-2006
2001
Sus scrofa
brenda
Okamura, M.
Purification and properties of L-gulono-1,4-lactone oxidase from Grifola frondosa
J. Nutr. Sci. Vitaminol.
47
258-261
2001
Grifola frondosa
brenda
Braun, L.; Mile, V.; Schaff, Z.; Csala, M.; Kardon, T.; Mandl, J.; Banhegyi, G.
Induction and peroxisomal appearance of gulonolactone oxidase upon clofibrate treatment in mouse liver
FEBS Lett.
458
359-362
1999
Mus musculus, no activity in Cavia porcellus, no activity in Homo sapiens, no activity in primates
brenda
Krasnov, A.; Reinisalo, M.; Pitknen, T.I.; Nishikimi, M.; Mlsa, H.
Expression of rat gene L-gulono-gamma-lactone oxidase, the key enzyme of L-ascorbic acid biosynthesis, in guinea pig cells and in teleost fish rainbow trout (Oncorhynchus mykiss)
Biochim. Biophys. Acta
1381
241-248
1998
no activity in Cavia porcellus, no activity in Oncorhynchus mykiss, Rattus norvegicus
brenda
Puskas, F.; Braun, L.; Csala, M.; Kardon, T.; Marcolongo, P.; Benedetti, A.; Mandl, J.; Banhegyi, G.
Gulonolactone oxidase activity-dependent intravesicular glutathione oxidation in rat liver microsomes
FEBS Lett.
430
293-296
1998
Rattus norvegicus
brenda
Yagi, K.; Nishimi, M.
Expression of recombinant L-gulono-gamma-lactone oxidase
Methods Enzymol.
279
24-29
1997
no activity in Cavia porcellus, no activity in Homo sapiens, Rattus norvegicus, no activity in primates
brenda
Sugisawa, T.; Ojima, S.; Matzinger, P.K.; Hoshino, T.
Isolation and characterization of a new vitamin C producing enzyme (L-gulono-gamma-lactone dehydrogenase) of bacterial origin
Biosci. Biotechnol. Biochem.
59
190-196
1995
Gluconobacter oxydans
-
brenda
Fujitsuka, N.; Yokozawa, T.; Oura, H.; Akao, T.; Kobashi, K.; Ienaga, K.; Nakamura, K.
L-Gulono-gamma-lactone oxidase is the enzyme responsible for the production of methylguanidine in the rat liver
Nephron
63
445-451
1993
Rattus norvegicus
brenda
Koshizaka, T.; Nishikimi, M.; Ozawa, T.; Yagi, K.
Isolation and sequence analysis of a complementary DNA encoding rat liver L-gulono-gamma-lactone oxidase, a key enzyme for L-ascorbic acid biosynthesis
J. Biol. Chem.
263
1619-1621
1988
no activity in Cavia porcellus, no activity in Homo sapiens, Rattus norvegicus, no activity in primates
brenda
Wallace, C.A.; Jenness, R.; Mullin, R.J.; Herman, W.S.
L-gulonolactone oxidase is present in the invertebrate, Limulus polyphemus
Experientia
41
485-486
1985
Gallus gallus, Limulus polyphemus, Rattus norvegicus
-
brenda
Yew, M.S.
Biosynthesis of ascorbic acid in chick embryos
Experientia
41
943-944
1985
Gallus gallus
brenda
Kiuchi, K.; Nishikimi, M.; Yagi, K.
Purification and characterization of L-gulonolactone oxidase from chicken kidney microsomes
Biochemistry
21
5076-5082
1982
Gallus gallus
brenda
Nishikimi, M.; Yamauchi, N.; Kiuchi, K.; Yagi, K.
Homology of L-gulonolactone oxidase of species belonging to Mammalia, Aves, and Amphibia
Experientia
37
479-480
1981
Gallus gallus, Lithobates catesbeianus, Rattus norvegicus
brenda
Birney, E.C.; Jenness, R.; Hume, I.D.
Ascorbic acid biosynthesis in the mammalian kidney
Experientia
35
1425-1426
1979
Isoodon macrourus, Notamacropus rufogriseus, Ornithorhynchus anatinus, Perameles nasuta, Tachyglossus aculeatus, Thylogale thetis
brenda
Nishikimi, M.
L-Gulono-gamma-lactone oxidase (rat and goat liver)
Methods Enzymol.
62
24-30
1979
Capra hircus, no activity in Cavia porcellus, no activity in Homo sapiens, no activity in primates, Rattus norvegicus
brenda
Nishikimi, M.; Kiuchi, K.; Yagi, K.
Detection of L-gulono-gamma-lactone oxidase on SDS-polyacrylamide gels by the fluorescence of its covalently bound flavin
FEBS Lett.
81
323-325
1977
Gallus gallus, Oryctolagus cuniculus, no activity in Cavia porcellus, Lithobates catesbeianus, Rattus norvegicus, no activity in primates
brenda
Nishikimi, M.; Tolbert, B.M.; Udenfriend, S.
Purification and characterization of L-gulono-gamma-lactone oxidase from rat and goat liver
Arch. Biochem. Biophys.
175
427-435
1976
Capra hircus, Rattus norvegicus
brenda
Ayaz, K.M.; Jenness, R.; Birney, E.C.
An improved assay for L-gulonolaction oxidase
Anal. Biochem.
72
161-171
1976
Rattus norvegicus
brenda
Kenney, W.C.; Edmondson, D.E.; Singer, T.P.
Identification of the covalently bound flavin of L-gulono-gamma-lactone oxidase
Biochem. Biophys. Res. Commun.
71
1194-1200
1976
no activity in Cavia porcellus, Rattus norvegicus, no activity in primates
brenda
Nakagawa, H.; Asano, A.; Sato, R.
Ascorbate-synthesizing system in rat liver microsomes. II. A peptide-bound flavin as the prosthetic group of L-gulono-gamma-lactone oxidase
J. Biochem.
77
221-232
1975
no activity in Cavia porcellus, Rattus norvegicus, no activity in primates
brenda
Nakagawa, H.; Assano, A.
Ascorbate synthesizing system in rat liver microsomes. I. Gulonolactone-reducible pigment as a prosthetic group of gulonolactone oxidase
J. Biochem.
68
737-746
1970
Rattus norvegicus
brenda
Eliceiri, G.L.; Lai, E.K.; McCay, P.B.
Gulonolactone oxidase. Solubilization, properties, and partial purification
J. Biol. Chem.
244
2641-2645
1969
Rattus norvegicus
brenda
Nam, Y.K.; Cho, Y.S.; Douglas, S.E.; Gallant, J.W.; Reith, M.E.; Kim, D.S.
Isolation and transient expression of a cDNA encoding L-gulono-gamma-lactone oxidase, a key enzyme for L-ascorbic acid biosynthesis, from the tiger shark Scyliorhinus torazame.
Aquaculture
209
271-284
2002
Silurus asotus, Scyliorhinus torazame
brenda
Moreau, R.; Dabrowski, K.
alpha-Tocopherol downregulates gulonolactone oxidase activity in sturgeon
Free Radic. Biol. Med.
34
1326-1332
2003
Acipenser transmontanus
brenda
Ha, M.N.; Graham, F.L.; D'Souza, C.K.; Muller, W.J.; Igdoura, S.A.; Schellhorn, H.E.
Functional rescue of vitamin C synthesis deficiency in human cells using adenoviral-based expression of murine l-gulono-gamma-lactone oxidase
Genomics
83
482-492
2004
Mus musculus (P58710), Mus musculus
brenda
Kim, B.K.; Park, S.Y.; Jeon, B.Y.; Hwang, D.Y.; Min, B.W.
Metabolic engineering increased vitamin C levels in lettuce by overexpression of a L-gulono-gamma-lactone oxidase
J. Korean Soc. Hort. Sci.
45
16-20
2004
Agrobacterium tumefaciens
-
brenda
Radzio, J.A.; Lorence, A.; Chevone, B.I.; Nessler, C.L.
L-Gulono-1,4-lactone oxidase expression rescues vitamin C-deficient Arabidopsis (vtc) mutants
Plant Mol. Biol.
53
837-844
2003
Rattus norvegicus
brenda
Kim, H.J.; Lee, S.I.; Lee, D.H.; Smith, D.; Jo, H.; Schellhorn, H.E.; Boo, Y.C.
Ascorbic acid synthesis due to L-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cells
Biochem. Biophys. Res. Commun.
345
1657-1662
2006
Mus musculus
brenda
Wolucka, B.A.; Communi, D.
Mycobacterium tuberculosis possesses a functional enzyme for the synthesis of vitamin C, L-gulono-1,4-lactone dehydrogenase
FEBS J.
273
4435-4445
2006
Mycobacterium tuberculosis
brenda
Troadec, M.; Kaplan, J.
Some vertebrates go with the GLO
Cell
132
921-922
2008
no activity in Homo sapiens
brenda
Cho, Y.S.; Douglas, S.E.; Gallant, J.W.; Kim, K.Y.; Kim, D.S.; Nam, Y.K.
Isolation and characterization of cDNA sequences of L-gulono-gamma-lactone oxidase, a key enzyme for biosynthesis of ascorbic acid, from extant primitive fish groups
Comp. Biochem. Physiol. B
147B
178-190
2007
Acipenser transmontanus, Triakis scyllium, Mustelus manazo
-
brenda
Yan, J.; Jiao, Y.; Li, X.; Jiao, F.; Beamer, W.G.; Rosen, C.J.; Gu, W.
Evaluation of gene expression profiling in a mouse model of L-gulonolactone oxidase gene deficiency
Genet. Mol. Biol.
30
322-329
2007
no activity in Mus musculus
brenda
Lee, C.W.; Wang, X.D.; Chien, K.L.; Ge, Z.; Rickman, B.H.; Rogers, A.B.; Varro, A.; Whary, M.T.; Wang, T.C.; Fox, J.G.
Vitamin C supplementation does not protect L-gulono-gamma-lactone oxidase-deficient mice from Helicobacter pylori-induced gastritis and gastric premalignancy
Int. J. Cancer
122
1068-1076
2008
no activity in Mus musculus
brenda
Li, Y.; Shi, C.; Mossman, K.; Rosenfeld, J.; Boo, Y.; Schellhorn, H.
Restoration of vitamin C synthesis in transgenic Gulo-/- mice by helper-dependent adenovirus-based expression of gulonolactone oxidase
Hum. Gene Ther.
19
1349-1357
2008
Mus musculus (P58710), Mus musculus
brenda
Maurice, D.; Lightsey, S.; Toler, J.; Abudabos, A.; Lindler, H.
L-gulonolactone oxidase activity, tissue ascorbic acid and total antioxidant capacity in vitamin A-deficient chickens, gallus gallus
J. Poultry Sci.
46
13-18
2009
Gallus gallus
-
brenda
Harrison, F.E.; Meredith, M.E.; Dawes, S.M.; Saskowski, J.L.; May, J.M.
Low ascorbic acid and increased oxidative stress in gulo(-/-) mice during development
Brain Res.
1349
143-152
2010
Mus musculus
brenda
Herbas, M.S.; Suzuki, H.
Vitamin C deficiency fails to protect mice from malaria
Exp. Anim.
59
239-243
2010
Mus musculus
brenda
Ocalewicz, K.; Dabrowski, K.; Mambrini, M.
Evidence for the possible existence of a remnant L-gulono-gamma-lactone oxidase (GULO) gene in a teleost genome
Folia Biol. (Krakow)
58
51-54
2010
Acipenser baerii, Acipenser fulvescens, Amia calva, Cyprinus carpio, Scyliorhinus torazame (Q90YK3), Scyliorhinus torazame
brenda
Nejak-Bowen, K.N.; Zeng, G.; Tan, X.; Cieply, B.; Monga, S.P.
Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver
J. Biol. Chem.
284
28115-28127
2009
Mus musculus
brenda
Maruta, T.; Ichikawa, Y.; Mieda, T.; Takeda, T.; Tamoi, M.; Yabuta, Y.; Ishikawa, T.; Shigeoka, S.
The contribution of Arabidopsis homologs of L-gulono-1,4-lactone oxidase to the biosynthesis of ascorbic acid
Biosci. Biotechnol. Biochem.
74
1494-1497
2010
Arabidopsis thaliana (O81030), Arabidopsis thaliana (Q6NQ66), Arabidopsis thaliana (Q9LYD8)
brenda
Akbarzadeh, A.; Farahmand, H.; Mahjoubi, F.; Nematollahi, M.A.; Leskinen, P.; Rytkoenen, K.; Nikinmaa, M.
The transcription of l-gulono-gamma-lactone oxidase, a key enzyme for biosynthesis of ascorbate, during development of Persian sturgeon Acipenser persicus
Comp. Biochem. Physiol. B
158
282-288
2011
Acipenser persicus
brenda
Gong, X.; Niu, C.; Zhang, Z.
cDNA cloning and tissue expression for L-gulonolactone oxidase gene in soft-shelled turtle Pelodiscus sinensis a species with the ability to synthesize ascorbic acid
Fish. Sci.
77
547-555
2011
Pelodiscus sinensis
-
brenda
Lim, M.; Pulla, R.; Park, J.; Harn, C.; Jeong, B.
Over-expression of L-gulono-gamma-lactone oxidase (GLOase) gene leads to ascorbate accumulation with enhanced abiotic stress tolerance in tomato
In Vitro Cell. Dev. Biol. Plant
48
453-461
2012
Solanum lycopersicum
-
brenda
Akbarzadeh, A.; Haghbeen, K.; Farahmand, H.; Nematollahi, M.; Nikinmaa, M.
The time course of L-gulono-gamma-lactone oxidase expression during the larval ontogeny of fish (Acipenser persicus)
Mar. Freshw. Behav. Physiol.
45
349-355
2013
Acipenser persicus
-
brenda
Ching, B.; Ong, J.L.; Chng, Y.R.; Chen, X.L.; Wong, W.P.; Chew, S.F.; Ip, Y.K.
L-gulono-gamma-lactone oxidase expression and vitamin C synthesis in the brain and kidney of the African lungfish, Protopterus annectens
FASEB J.
28
3506-3517
2014
no activity in Homo sapiens, Protopterus annectens (A0A067XNL8)
brenda
Lisko, K.A.; Torres, R.; Harris, R.S.; Belisle, M.; Vaughan, M.M.; Jullian, B.; Chevone, B.I.; Mendes, P.; Nessler, C.L.; Lorence, A.
Elevating vitamin C content via overexpression of myo-inositol oxygenase and l-gulono-1,4-lactone oxidase in Arabidopsis leads to enhanced biomass and tolerance to abiotic stresses
In Vitro Cell. Dev. Biol. Plant
49
643-655
2013
Arabidopsis thaliana, Arabidopsis thaliana Col-0
brenda
Henriques, S.F.; Duque, P.; Lopez-Fernandez, H.; Vazquez, N.; Fdez-Riverola, F.; Reboiro-Jato, M.; Vieira, C.P.; Vieira, J.
Multiple independent L-gulonolactone oxidase (GULO) gene losses and vitamin C synthesis reacquisition events in non-Deuterostomian animal species
BMC Evol. Biol.
19
126
2019
unidentified
brenda
Zhou, H.; Milne, R.; Ma, X.; Song, Y.; Fang, J.; Sun, H.; Zha, H.
Characterization of a L-gulono-1,4-lactone oxidase like protein in the floral nectar of Mucuna sempervirens, fabaceae
Front. Plant Sci.
9
1109
2018
Mucuna sempervirens (A0A290U7F5), Mucuna sempervirens
brenda
Aboobucker, S.I.; Suza, W.P.; Lorence, A.
Characterization of two Arabidopsis L-gulono-1,4-lactone oxidases, AtGulLO3 and AtGulLO5, involved in ascorbate biosynthesis
React. Oxyg. Species (Apex)
4
389-417
2017
Arabidopsis thaliana (O81030), Arabidopsis thaliana (Q9LYD8)
brenda