Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 1.1.1.381 - 3-hydroxy acid dehydrogenase

for references in articles please use BRENDA:EC1.1.1.381
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. The highest activity is seen with L-allo-threonine and D-threonine. The enzyme from Escherichia coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2-methylpropanoate. The enzyme has no activity with NAD+ or L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase).
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
Synonyms
ymr226c, 3-hydroxy acid dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-2-amino-3-oxobutanoate = aminoacetone + CO2
show the reaction diagram
(1b), spontaneous
-
-
-
L-allo-threonine + NADP+ = aminoacetone + CO2 + NADPH + H+
show the reaction diagram
overall reaction
-
-
-
L-allo-threonine + NADP+ = L-2-amino-3-oxobutanoate + NADPH + H+
show the reaction diagram
(1a)
-
-
-
PATHWAY SOURCE
PATHWAYS
Select items on the left to see more content.