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EC Tree
The expected taxonomic range for this enzyme is: Archaea, Bacteria, Eukaryota
Synonyms
g3pdh, glycerin-3-phosphate dehydrogenase, nad(p)+-dependent glycerol-3-phosphate dehydrogenase,
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glycerin-3-phosphate dehydrogenase
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glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase
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L-glycerol 3-phosphate:NADP oxidoreductase
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NAD(P)+-dependent glycerol-3-phosphate dehydrogenase
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NADPH-dependent glycerin-3-phosphate dehydrogenase
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sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + NADPH + H+
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sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase
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D-glyceraldehyde 3-phosphate + NADPH
L-alpha-glycerol 3-phosphate + NADP+
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r
L-alpha-glycerol 3-phosphate + NADP+
D-glyceraldehyde 3-phosphate + NADPH
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sn-glycerol 3-phosphate + NAD+
D-glyceraldehyde 3-phosphate + NADH + H+
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sn-glycerol 3-phosphate + NADP+
D-glyceraldehyde 3-phosphate + NADPH + H+
additional information
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no enzymic activity with dihydroxyacetone, glycerol, glycerol-2-phosphate, D-glyceraldehyde-3-phosphate, DL-glyceraldehyde, D-erythrose-4-phosphate, D-fructose-4-phosphate
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sn-glycerol 3-phosphate + NADP+
D-glyceraldehyde 3-phosphate + NADPH + H+
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sn-glycerol 3-phosphate + NADP+
D-glyceraldehyde 3-phosphate + NADPH + H+
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involved in a shortened pentose phosphate pathway of the utilization of glucose in muscle tissue
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sn-glycerol 3-phosphate + NAD+
D-glyceraldehyde 3-phosphate + NADH + H+
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sn-glycerol 3-phosphate + NADP+
D-glyceraldehyde 3-phosphate + NADPH + H+
sn-glycerol 3-phosphate + NADP+
D-glyceraldehyde 3-phosphate + NADPH + H+
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sn-glycerol 3-phosphate + NADP+
D-glyceraldehyde 3-phosphate + NADPH + H+
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involved in a shortened pentose phosphate pathway of the utilization of glucose in muscle tissue
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r
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NADP+
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D-glyceraldehyde 3-phosphate
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L-alpha-glycerol 3-phosphate
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Adenoma, Bile Duct
Enzyme histochemical and immunohistochemical characterization of oval and parenchymal cells proliferating in livers of rats fed a choline-deficient/DL-ethionine-supplemented diet.
Adenoma, Liver Cell
Enzyme histochemical and immunohistochemical characterization of oval and parenchymal cells proliferating in livers of rats fed a choline-deficient/DL-ethionine-supplemented diet.
Anemia, Sickle Cell
Decreased G3PDH binding to erythrocyte membranes in sickle cell disease.
Arthritis
Oxidation of articular cartilage glyceraldehyde-3-phosphate dehydrogenase (G3PDH) occurs in vivo during carrageenin-induced arthritis.
Dyslipidemias
Low abdominal subcutaneous preadipocyte adipogenesis is associated with visceral obesity, visceral adipocyte hypertrophy, and a dysmetabolic state.
Infections
Establishment of a quiescent herpes simplex virus type 1 infection in neurally-differentiated PC12 cells.
Insulin Resistance
Glycerol-3-phosphate dehydrogenase activity in human lymphocytes: effects of insulin, obesity and weight loss.
Leiomyoma
Expression of exon 5 deleted estrogen receptor variant messenger RNA in human uterine myometrium and leiomyoma.
Leukemia
KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Detection of messenger RNA in leukocytes or plasma of patients with chronic myeloid leukemia.
Leukemia, Myeloid
KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells.
Lung Diseases, Interstitial
Chemokine gene expression and clonal analysis of B cells in tissues involved by lymphoid interstitial pneumonitis from HIV-infected pediatric patients.
Microphthalmos
Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter.
Myelodysplastic Syndromes
KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells.
Neoplasms
Expression of exon 5 deleted estrogen receptor variant messenger RNA in human uterine myometrium and leiomyoma.
Neoplasms
Glyceraldehyde-3-phosphate dehydrogenase mRNA expression in hepatocellular carcinoma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells.
Prostatic Neoplasms
Simultaneous detection of circulating prostate specific antigen (PSA)-expressing and prostate specific membrane antigen (PSM)-expressing cells by a multiplex reverse transcriptase polymerase chain reaction (RT-PCR) assay.
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1
D-glyceraldehyde 3-phosphate
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pH 6.6, 70°C
0.1
L-alpha-glycerol 3-phosphate
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pH 6.6, 70°C
0.04
NADPH
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pH 6.6, 70°C
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0.1
D-glyceraldehyde 3-phosphate
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pH 6.6, 70°C
17
L-alpha-glycerol 3-phosphate
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pH 6.6, 70°C
0.005
NADP+
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pH 6.6, 70°C
additional information
additional information
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KI-value for NADPH is below 0.005 mM
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4
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pH 6.6, 70°C, substrate L-alpha-glycerol 3-phosphate
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pH 6.6, 70°C, substrate D-glyceraldehyde 3-phosphate
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5
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or below, reduction reaction
9.5
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or above, oxidation reaction
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5
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deduced from gene sequence
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recombinant enzyme
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brenda
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brenda
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brenda
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myocardium, intermediate activity
brenda
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low activity
brenda
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highest activity
brenda
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dimer
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crystallization data
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85
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30 min, in presence of 200 mM potassium phosphate or 100 mM NaCl or 50 mM ammonium sulfate, completely stable
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expressed in Escherichia coli Tuner cells
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Glushankov, E.P.; Epifanova, Y.E.; Kolotilova, A.I.
Pentose phosphate pathway of carbohydrate metabolism and NADP-dependent glycerin-3-phosphate dehydrogenase activity in some tissues of white rats
Biokhimiya
41
1788-1790
1976
Rattus sp.
brenda
Sakasegawa, S.I.; Hagemeier, C.H.; Thauer, R.K.; Essen, L.O.; Shima, S.
Structural and functional analysis of the gpsA gene product of Archaeoglobus fulgidus: A glycerol-3-phosphate dehydrogenase with an unusual NADP+ preference
Protein Sci.
13
3161-3171
2004
Archaeoglobus fulgidus
brenda
Rho, H.; Choi, K.
Cofactor regeneration using permeabilized Escherichia coli expressing NAD(P)+-dependent glycerol-3-phosphate dehydrogenase
J. Microbiol. Biotechnol.
28
1346-1351
2018
Escherichia coli
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