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IUBMB CommentsActs on a variety of 2-alkyn-1-ols, and also on 1,4-butanediol. NADP+ also acts as acceptor, but more slowly.
The expected taxonomic range for this enzyme is: Fusarium merismoides
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2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + NADH + H+
Acts on a variety of 2-alkyn-1-ols, and also on 1,4-butanediol. NADP+ also acts as acceptor, but more slowly
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2-butyne-1,4-diol:NAD+ 1-oxidoreductase
Acts on a variety of 2-alkyn-1-ols, and also on 1,4-butanediol. NADP+ also acts as acceptor, but more slowly.
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1,2,4-butanetriol + NAD+
? + NADH
1,2-butanediol + NAD+
1-hydroxybutan-2-one + NADH
1,2-propanediol + NAD+
1-hydroxy-2-propanal + NADH
1,4-butanediol + NAD+
1-hydroxy-4-butanal + NADH
1,6-hexanediol + NAD+
1-hydroxy-6-hexanal + NADH
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low activity
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?
1-butene-3-ol + NAD+
1-buten-3-one + NADH
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low activity
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?
1-butyne-3-ol + NAD+
1-butyne-3-one + NADH
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very low activity
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?
2-butene-1-ol + NAD+
2-butene-1-al + NADH
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cis-trans mixture, very low activity
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?
2-butyne-1,4-diol + NAD+
4-hydroxybut-2-ynal + NADH
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?
2-butyne-1-ol + NAD+
2-butyn-1-al + NADH
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highest activity
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?
2-propene-1-ol + NAD+
2-propene-1-al + NADH
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low activity
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?
2-propyne-1-ol + NAD+
2-propyn-1-al + NADH
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?
3-butyne-1-ol + NAD+
3-butyn-1-al + NADH
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very low activity
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?
n-propanol + NAD+
n-propanal + NADH
trans-2-butene-1,4-diol + NAD+
? + NADH
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?
1,2,4-butanetriol + NAD+
? + NADH
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low activity
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?
1,2,4-butanetriol + NAD+
? + NADH
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low activity
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?
1,2-butanediol + NAD+
1-hydroxybutan-2-one + NADH
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low activity
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?
1,2-butanediol + NAD+
1-hydroxybutan-2-one + NADH
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low activity
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?
1,2-propanediol + NAD+
1-hydroxy-2-propanal + NADH
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?
1,2-propanediol + NAD+
1-hydroxy-2-propanal + NADH
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?
1,4-butanediol + NAD+
1-hydroxy-4-butanal + NADH
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?
1,4-butanediol + NAD+
1-hydroxy-4-butanal + NADH
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?
n-propanol + NAD+
n-propanal + NADH
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low activity
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?
n-propanol + NAD+
n-propanal + NADH
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low activity
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?
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2-butyne-1,4-diol + NAD+
4-hydroxybut-2-ynal + NADH
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?
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NADP+
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one third of the activity compared to NAD+
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CuCl2
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complete inhibition at 2 mM
HgCl2
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complete inhibition at 2 mM
iodoacetic acid
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complete inhibition at 2 mM
KCN
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slight inhibition at 2 mM
NaN3
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slight inhibition at 2 mM
Ni2+
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84% inhibition at 2 mM
p-chloromercuribenzoate
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complete inhibition at 2 mM
Zn2+
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55% inhibition at 2 mM
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9.1
2-butyne-1,4-diol
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strainB11
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brenda
strainB11
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brenda
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highest induction of enzyme formation by use of 2-butyne-1,4-diol-containing growth media
brenda
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highest induction of enzyme formation by use of 2-butyne-1,4-diol-containing growth media
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brenda
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5.8 - 8.5
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stable between
286099
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40
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stable below, rapid decrease of activity above
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highly labile, even in the presence of DTT
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to homogeneity, chromatography techniques
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Miyoshi, T.; Sato, H.; Harada, T.
Purification and characterization of 2-alkyne-1-ol dehydrogenase induced by 2-butyne-1,4-diol in Fusarium merismoides B11
Biochim. Biophys. Acta
358
231-239
1974
Fusarium merismoides, Fusarium merismoides B11
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brenda
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Enzyme Nomenclature
1.1.1.165 2-alkyn-1-ol dehydrogenase
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