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The expected taxonomic range for this enzyme is: Homo sapiens
Synonyms
bunolol reductase, dehydrogenase, dihydrobunolol,
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bunolol reductase
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dehydrogenase, dihydrobunolol
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(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+ = (+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH + H+
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(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase
Also acts, more slowly, with NAD+.
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(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+
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i.e. bunolol, r, also acts more slowly with NAD+
i.e. dihydrobunolol
r
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
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i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver
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(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
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i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver
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brenda
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brenda
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brenda
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-17°C, 4 months, completely stable
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Leinweber, F.J.; Greenough, R.C.; Schwender, C.F.; Kaplan, H.R.; di Carlo, F.J.
Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol
Xenobiotica
2
191-202
1972
Homo sapiens
brenda
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